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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN15 Gene

protein-coding   GIFtS: 54
GCID: GC07M100875

Claudin 15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Claudin 151 2
claudin-152

External Ids:    HGNC: 20361   Entrez Gene: 241462   Ensembl: ENSG000001064047   UniProtKB: P567463   

Export aliases for CLDN15 gene to outside databases

Previous GC identifers: GC07M099358 GC07M100421 GC07M100435 GC07M100471 GC07M100662 GC07M095468


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN15 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for CLDN15 Gene: 
CLDN15 (claudin 15) is a protein-coding gene. Diseases associated with CLDN15 include malignant peritoneal mesothelioma, and peritonitis, and among its related super-pathways are Cell-cell junction organization and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN15 gene promoter:
         Max1   MAZR   NRSF form 1   NRSF form 2   Arnt   YY1   FOXO1a   Pax-4a   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN15 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

CLDN15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN15 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100875:  view genomic region     (about GC identifiers)

Start:
100,875,373 bp from pter      End:
100,882,101 bp from pter
Size:
6,729 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,233,760-100,240,488     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746 (See protein sequence)
Recommended Name: Claudin-15  
Size: 228 amino acids; 24356 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Secondary accessions: B3KPB5

Explore the universe of human proteins at neXtProt for CLDN15: NX_P56746

Explore proteomics data for CLDN15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56746

  • CLDN15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLDN15 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055158.1  NP_001172009.1  

    ENSEMBL proteins: 
     ENSP00000308870   ENSP00000385300   ENSP00000405308   ENSP00000398418   ENSP00000390230  
    Reactome Protein details: P56746
    Human Recombinant Protein Products for CLDN15: 
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    Novus Biologicals CLDN15 Protein
    Novus Biologicals CLDN15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLDN15 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--

    CLDN15 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CLDN15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR008094 Claudin15

    Graphical View of Domain Structure for InterPro Entry P56746

    ProtoNet protein and cluster: P56746

    2 Blocks protein domains:
    IPB006187 Claudin family signature
    IPB008094 Claudin-15 signature


    UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746
    Similarity: Belongs to the claudin family


    CLDN15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD15_HUMAN, P56746
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Genatlas biochemistry entry for CLDN15:
    claudin 15,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,expressed in colon,fetal liver,spleen,breast

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--
         
    CLDN15 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cldn15):
     cellular  digestive/alimentary  endocrine/exocrine gland 

    CLDN15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cldn15tm1Sats for CLDN15

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN15 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLDN15 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Tight junction
    Tight junction
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN15
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    4        Reactome Pathways for CLDN15
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN15):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CLDN15 (ENSP000003088704) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN12ENSP000002879164STRING: ENSP00000287916
    CLDN14ENSP000003392924STRING: ENSP00000339292
    CLDN17ENSP000002868084STRING: ENSP00000286808
    CLDN18ENSP000001836054STRING: ENSP00000183605
    CLDN20ENSP000003561334STRING: ENSP00000356133
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--

    CLDN15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN15 (CLD15)

    1 HMDB Compound for CLDN15    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CLDN15 / CLD15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN15 gene (3 alternative transcripts): 
    NM_014343.2  NM_138429.1  NM_001185080.1  

    Unigene Cluster for CLDN15:

    Claudin 15
    Hs.38738  [show with all ESTs]
    Unigene Representative Sequence: NM_001185080
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308344(uc003uyg.2) ENST00000401528(uc003uyh.2) ENST00000433833
    ENST00000414035 ENST00000412417 ENST00000463331(uc003uyi.3 uc022aja.1)
    ENST00000433422
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN15

    Additional mRNA sequence: 

    AJ245738.1 AK056103.1 BC010160.1 

    10 DOTS entries:

    DT.110692  DT.91749561  DT.100000665  DT.91734186  DT.100746771  DT.97842928  DT.95260306  DT.100746769 
    DT.121126419  DT.95074538 

    24/325 AceView cDNA sequences (see all 325):

    AA192762 BQ448236 BM997988 BM764542 BE876790 BQ695317 BQ026742 AI609056 
    AI148099 BI836529 BC003540 NM_014343 BE795653 BU169378 BM832816 BQ001742 
    CA419123 AK056103 BC010160 BM695658 BM784371 BM805626 BI225269 H95941 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
    SP1:              -     -                 -           -     -                                 
    SP2:                                      -     -     -     -                                 
    SP3:                    -                                                                     
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CLDN15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN15 expression in normal human tissues (normalized intensities)      CLDN15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCTCCAG
    CLDN15 Expression
    About this image


    CLDN15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Stomach (Gastrointestinal Tract)

    See CLDN15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN15

    SOURCE GeneReport for Unigene cluster: Hs.38738
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN15: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN15 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn151 , 5 claudin 151, 5 82.38(n)1
    78.41(a)1
      5 (76.07 cM)5
    603631  NM_021719.41  NP_068365.11 
     1369666165 
    chicken
    (Gallus gallus)
    Aves CLDN156
    Uncharacterized protein
    36(a)
    1 ↔ 1
    9(2183674-2204182)
    lizard
    (Anolis carolinensis)
    Reptilia CLDN156
    --
    --
    60(a)
    37(a)
    1 ↔ 1
    possible ortholog
    GL343220.1(54351-65134)
    3(37968681-37998526)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639432 hypothetical protein MGC63943 73.77(n)   393375  BC054577.1 


    ENSEMBL Gene Tree for CLDN15 (if available)
    TreeFam Gene Tree for CLDN15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN15 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN102  CLDN22  
    CLDN12  CLDN32  CLDN142  CLDN62  CLDN72  CLDN192  
    17 SIMAP similar genes for CLDN15 using alignment to 5 protein entries:     CLD15_HUMAN (see all proteins):
    CLDN7    CLDN10    CLDN18    CLDN19    CLDN20    CLDN1
    CLDN3    CLDN4    CLDN5    CLDN2    CLDN6    CLDN8
    CLDN9    CLDN14    CLDN22    CLDN24    CLDN17

    CLDN15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/168 SNPs in CLDN15 are shown (see all 168)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888671691,2
    C--100874979(+) GAGAAA/GGTCTC 2 -- ds5001 int10--------
    rs1811887151,2
    --100875040(+) CCTGAG/TAACCA 2 -- ds5001 int10--------
    rs560371051,2
    C,F--100875200(+) TCTTAC/ACAGCA 2 -- ds5001 int12Minor allele frequency- A:0.11WA 120
    rs1862313931,2
    --100875336(+) TCACCC/GCTTGC 2 -- ds5001 int10--------
    rs1905034581,2
    --100875406(+) GAATGC/TATTTA 2 -- ut310--------
    rs2002755141,2
    --100875542(+) CCATG-/AAGAGT 2 -- ut310--------
    rs1839903741,2
    C--100875678(+) GCCCAC/TGGGCC 2 -- ut310--------
    rs2008463071,2
    --100875757(+) GCGACA/GGGCAT 4 P syn10--------
    rs1499253211,2
    C--100875770(+) CGGACA/GCTGGA 4 A V mis10--------
    rs10473191,2
    C,F,A,H--100875772(-) GCTCCA/CGTGTC 4 P syn1 ese326Minor allele frequency- C:0.22NA NS EA CSA WA EU 7856

    HapMap Linkage Disequilibrium report for CLDN15 (100875373 - 100882101 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CLDN15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2422376CNV Duplication17116639
    esv2422326CNV Duplication17116639
    nsv5875CNV Insertion18451855
    nsv831075CNV Loss17160897
    nsv831076CNV Loss17160897
    nsv831077CNV Loss17160897
    dgv7409n71CNV Loss21882294
    dgv7410n71CNV Loss21882294
    esv2752134CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for CLDN15:    About MalaCards
    malignant peritoneal mesothelioma    peritonitis    endotheliitis    hepatitis c
    colon cancer    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CLDN15:
    Malignant peritoneal mesothelioma

    CLDN15 for disorders           About GeneDecksing


    Export disorders for CLDN15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN15 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with CLDN15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Impact of ancestry and common genetic variants on QT i nterval in African Americans. (PubMed id 23166209)1 Smith J.G....Newton-Cheh C. (2012)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    5. Ion transport and barrier function in a telomerase-im mortalized human nondysplastic, Barrett's cell line (BAR-T). (PubMed id 19673046)1 Jovov B....Orlando R.C. (2009)
    6. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
    7. Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. (PubMed id 19420749)1 Takehara M....Mizushima T. (2009)
    8. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
    9. Claudins--key pieces in the tight junction puzzle. (PubMed id 16798613)1 Koval M. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 24146 HGNC: 2036 AceView: CLDN15andTTC11 Ensembl:ENSG00000106404 euGenes: HUgn24146
    ECgene: CLDN15 Kegg: 24146 H-InvDB: CLDN15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN15 gene:
    Search GeneIP for patents involving CLDN15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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