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Aliases for CLDN15 Gene

Aliases for CLDN15 Gene

  • Claudin 15 2 3 5
  • Claudin-15 3

External Ids for CLDN15 Gene

Previous GeneCards Identifiers for CLDN15 Gene

  • GC07M099358
  • GC07M100421
  • GC07M100435
  • GC07M100471
  • GC07M100662
  • GC07M100875
  • GC07M095468

Summaries for CLDN15 Gene

Entrez Gene Summary for CLDN15 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN15 Gene

CLDN15 (Claudin 15) is a Protein Coding gene. Diseases associated with CLDN15 include Colonic Benign Neoplasm. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.

UniProtKB/Swiss-Prot for CLDN15 Gene

  • Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.

Gene Wiki entry for CLDN15 Gene

Additional gene information for CLDN15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN15 Gene

Genomics for CLDN15 Gene

GeneHancer (GH) Regulatory Elements for CLDN15 Gene

Promoters and enhancers for CLDN15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I101231 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 560.6 +2.0 1984 10.7 HDGF ATF1 MLX ARNT ARID4B SIN3A ZNF48 YY1 TCF12 GLIS2 CLDN15 FIS1 GIGYF1 SRRT STAG3L5P PCOLCE PPP1R35 PILRB LOC101927746 ZNHIT1
GH07I101243 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.2 -5.7 -5698 2.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 FIS1 CLDN15 GC07M101250
GH07I101215 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.6 +20.6 20637 4.7 FOXA2 PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 ZNHIT1 PLOD3 FIS1 GIGYF1 SRRT STAG3L5P PILRB PPP1R35 NAT16 EPHB4
GH07I101251 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 9.3 -13.3 -13287 1.8 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 E2F8 FIS1 GC07M101250 SRRT PPP1R35 GIGYF1 MEPCE STAG3L5P PILRB CLDN15
GH07I100835 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +402.0 401985 2.5 PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF213 ZNF3 TRIM4 SRRT GIGYF1 STAG3L5P ENSG00000242798 PPP1R35 AP4M1 PCOLCE PILRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLDN15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLDN15 gene promoter:

Genomic Locations for CLDN15 Gene

Genomic Locations for CLDN15 Gene
chr7:101,232,092-101,238,820
(GRCh38/hg38)
Size:
6,729 bases
Orientation:
Minus strand
chr7:100,875,373-100,882,101
(GRCh37/hg19)

Genomic View for CLDN15 Gene

Genes around CLDN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN15 Gene

Proteins for CLDN15 Gene

  • Protein details for CLDN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56746-CLD15_HUMAN
    Recommended name:
    Claudin-15
    Protein Accession:
    P56746
    Secondary Accessions:
    • B3KPB5

    Protein attributes for CLDN15 Gene

    Size:
    228 amino acids
    Molecular mass:
    24356 Da
    Quaternary structure:
    • Can form linear homooligomers in the membrane, giving rise to tight junction strand-like structures.

neXtProt entry for CLDN15 Gene

Post-translational modifications for CLDN15 Gene

Other Protein References for CLDN15 Gene

No data available for DME Specific Peptides for CLDN15 Gene

Domains & Families for CLDN15 Gene

Gene Families for CLDN15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Suggested Antigen Peptide Sequences for CLDN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56746

UniProtKB/Swiss-Prot:

CLD15_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN15: view

Function for CLDN15 Gene

Molecular function for CLDN15 Gene

GENATLAS Biochemistry:
claudin 15,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,expressed in colon,fetal liver,spleen,breast
UniProtKB/Swiss-Prot Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.

Phenotypes From GWAS Catalog for CLDN15 Gene

Gene Ontology (GO) - Molecular Function for CLDN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN15: view
genes like me logo Genes that share phenotypes with CLDN15: view

Animal Models for CLDN15 Gene

MGI Knock Outs for CLDN15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN15 Gene

Localization for CLDN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN15 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN15 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016328 lateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN15 Gene

Pathways & Interactions for CLDN15 Gene

genes like me logo Genes that share pathways with CLDN15: view

Gene Ontology (GO) - Biological Process for CLDN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN15: view

No data available for SIGNOR curated interactions for CLDN15 Gene

Drugs & Compounds for CLDN15 Gene

(1) Drugs for CLDN15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CLDN15: view

Transcripts for CLDN15 Gene

Unigene Clusters for CLDN15 Gene

Claudin 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for CLDN15 Gene

GeneLoc Exon Structure for
CLDN15
ECgene alternative splicing isoforms for
CLDN15

Expression for CLDN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of CLDN15 Gene:

CLDN15

SOURCE GeneReport for Unigene cluster for CLDN15 Gene:

Hs.38738

mRNA Expression by UniProt/SwissProt for CLDN15 Gene:

P56746-CLD15_HUMAN
Tissue specificity: Detected in colon (at protein level).

Evidence on tissue expression from TISSUES for CLDN15 Gene

  • Kidney(4.4)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with CLDN15: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN15 Gene

Orthologs for CLDN15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN15 33 34
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia CLDN15 33 34
  • 86.4 (n)
oppossum
(Monodelphis domestica)
Mammalia CLDN15 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn15 33 16 34
  • 82.38 (n)
rat
(Rattus norvegicus)
Mammalia Cldn15 33
  • 81.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CLDN15 34
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN15 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN15 34
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN15 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn15.1 33
  • 61.19 (n)
zebrafish
(Danio rerio)
Actinopterygii cldn15b 33 34
  • 55.19 (n)
cldn15a 34
  • 46 (a)
OneToMany
CLDN15 (2 of 4) 34
  • 28 (a)
OneToMany
CLDN15 (4 of 4) 34
  • 28 (a)
OneToMany
zgc63943 33
Species where no ortholog for CLDN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN15 Gene

ENSEMBL:
Gene Tree for CLDN15 (if available)
TreeFam:
Gene Tree for CLDN15 (if available)

Paralogs for CLDN15 Gene

Paralogs for CLDN15 Gene

genes like me logo Genes that share paralogs with CLDN15: view

Variants for CLDN15 Gene

Sequence variations from dbSNP and Humsavar for CLDN15 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000534152 -- 101,236,598(-) C/T intron_variant
rs1001533008 -- 101,235,347(-) T/C intron_variant
rs1001625482 -- 101,233,326(-) T/C intron_variant
rs1001890828 -- 101,239,546(-) G/A upstream_transcript_variant
rs1001968570 -- 101,238,571(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN15 Gene

Variant ID Type Subtype PubMed ID
dgv11534n54 CNV loss 21841781
esv2422326 CNV duplication 17116639
esv2422376 CNV duplication 17116639
esv2734888 CNV deletion 23290073
esv2752134 CNV gain 17911159
esv3614318 CNV loss 21293372
esv3614319 CNV gain 21293372
esv3614323 CNV loss 21293372
esv3614324 CNV gain 21293372
nsv1030604 CNV gain 25217958
nsv5875 CNV insertion 18451855
nsv607974 CNV loss 21841781
nsv607978 CNV loss 21841781
nsv831075 CNV loss 17160897
nsv831076 CNV loss 17160897
nsv831077 CNV loss 17160897

Variation tolerance for CLDN15 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN15 Gene

Disorders for CLDN15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLDN15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLDN15

genes like me logo Genes that share disorders with CLDN15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN15 Gene

Publications for CLDN15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. (PMID: 13129853) Van Itallie CM … Anderson JM (American journal of physiology. Renal physiology 2003) 3 4 58
  3. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. (PMID: 12055082) Colegio OR … Anderson JM (American journal of physiology. Cell physiology 2002) 3 4 58
  4. Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression. (PMID: 27869798) Wu RL … Turner JR (Laboratory investigation; a journal of technical methods and pathology 2017) 3 58
  5. A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations. (PMID: 28863193) Alberini G … Maragliano L (PloS one 2017) 3 58

Products for CLDN15 Gene

Sources for CLDN15 Gene

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