Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLDN15 Gene

protein-coding GIFtS: 55
GCID: GC07M100875

claudin 15

Explore 6 diseases affiliated with
CLDN15 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Claudin 15¹ ²
Claudin-15¹

External Ids:	HGNC: 2036¹	Entrez Gene: 24146²	Ensembl: ENSG00000106404⁷	UniProtKB: P56746³

Export aliases for CLDN15 gene to outside databases

Previous GC identifers: GC07M099358 GC07M100421 GC07M100435 GC07M100471 GC07M100662 GC07M095468

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN15:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight

junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely

through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in

maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same

protein have been found for this gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through

calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN15

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLDN15 gene promoter:
Max1 MAZR NRSF form 1 NRSF form 2 Arnt YY1 FOXO1a Pax-4a c-Myc FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN15 promoter sequence

Search SABiosciences Chromatin IP Primers for CLDN15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22

CLDN15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN15 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M100875: view genomic region (about GC identifiers)

Start:	100,875,373 bp from pter	End:	100,882,101 bp from pter
Size:	6,729 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 100,233,760-100,240,488

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746 (See protein sequence)

Recommended Name: Claudin-15

Size: 228 amino acids; 24356 Da

Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein

Secondary accessions: B3KPB5

Explore the universe of human proteins at neXtProt for CLDN15: NX_P56746

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P56746

CLDN15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_055158.1 NP_001172009.1

ENSEMBL proteins:

ENSP00000308870 ENSP00000385300 ENSP00000405308 ENSP00000398418 ENSP00000390230

Reactome Protein details: P56746
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CLDN15 OriGene Custom Protein Services for CLDN15
	GenScript Custom Purified and Recombinant Proteins Services for CLDN15
	Novus Biologicals CLDN15 Protein Novus Biologicals CLDN15 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CLDN15

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005923	tight junction	ISS	--
GO:0016021	integral to membrane	IEA	--

CLDN15 for ontologies About GeneDecksing

CLDN15 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CLDN15
	GenScript Custom Superior Antibodies Services for CLDN15
	Novus Biologicals CLDN15 Antibodies
	Search for Antibodies for CLDN15 at Abcam
	Uscn Antibodies for CLDN15
	ThermoFisher Antibodies for CLDN15

Assay Products for CLDN15:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CLDN15
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CLDN15

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLDN15 for domains About GeneDecksing

4 InterPro domains/families:

IPR017974 Claudin_CS

IPR006187 Claudin

IPR004031 PMP22/EMP/MP20/Claudin

IPR008094 Claudin15

Graphical View of Domain Structure for InterPro Entry P56746

ProtoNet protein and cluster: P56746

2 Blocks protein families:

IPB006187 Claudin family signature

IPB008094 Claudin-15 signature

UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746

Similarity: Belongs to the claudin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through

calcium-independent cell-adhesion activity (By similarity)

Genatlas biochemistry entry for CLDN15:

claudin 15,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural

components of tight junction (TJ) strands,expressed in colon,fetal liver,spleen,breast

miRNA Products:		OriGene 3'-UTR Clone: CLDN15 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN15
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLDN15
		SwitchGear 3'UTR luciferase reporter plasmid: CLDN15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN15 (see all 7) OriGene shRNA RFP: CLDN15 OriGene siRNA: CLDN15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN15

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CLDN15

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN15 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN15 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLDN15 (NM_014343)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN15

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CLDN15
		Search LifeMap BioReagents cell lines for CLDN15

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN15

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0042802	identical protein binding	ISS	--

CLDN15 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cldn15^tm1Sats for CLDN15
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cldn15):

cellular

digestive/alimentary

endocrine/exocrine gland

CLDN15 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell-cell junction organization

	Cell-cell junction organization	1.00			Tight junction interactions	0.49
	Cell junction organization	0.69			Cell-Cell communication	0.45

Sertoli-Sertoli Cell Junction Dynamics

Sertoli-Sertoli Cell Junction Dynamics

1.00

Epithelial Tight Junctions

0.36

Hepatitis C

Hepatitis C

1.00

Leukocyte transendothelial migration

Leukocyte transendothelial migration

1.00

Tight junction

Tight junction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN15

	Sertoli-Sertoli Cell Junction Dynamics
	Epithelial Tight Junctions
	Transendothelial Migration of Leukocytes

4 Reactome Pathways for CLDN15

	Tight junction interactions
	Cell junction organization
	Cell-Cell communication
	Cell-cell junction organization

4 Kegg Pathways (Kegg details for CLDN15):

	Cell adhesion molecules (CAMs)
	Tight junction
	Leukocyte transendothelial migration
	Hepatitis C

CLDN15 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CLDN15

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for CLDN15 (ENSP00000308870⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLDN12	ENSP00000287916⁴	STRING: ENSP00000287916
CLDN14	ENSP00000339292⁴	STRING: ENSP00000339292
CLDN17	ENSP00000286808⁴	STRING: ENSP00000286808
CLDN18	ENSP00000183605⁴	STRING: ENSP00000183605
CLDN20	ENSP00000356133⁴	STRING: ENSP00000356133

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016338	calcium-independent cell-cell adhesion	ISS	--
GO:0034329	cell junction assembly	TAS	--
GO:0045216	cell-cell junction organization	TAS	--
GO:0070830	tight junction assembly	TAS	--

CLDN15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLDN15

1 HMDB Compound for CLDN15 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CLDN15 / CLD15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLDN15 gene (3 alternative transcripts):

NM_014343.2 NM_138429.1 NM_001185080.1

Unigene Cluster for CLDN15:

Claudin 15

Hs.38738 [show with all ESTs]

Unigene Representative Sequence: NM_001185080

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308344(uc003uyg.2) ENST00000401528(uc003uyh.2) ENST00000433833

ENST00000414035 ENST00000412417 ENST00000463331(uc003uyi.3 uc022aja.1)

ENST00000433422

miRNA Products:		OriGene 3'-UTR Clone: CLDN15 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN15
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLDN15
		SwitchGear 3'UTR luciferase reporter plasmid: CLDN15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN15 (see all 7) OriGene shRNA RFP: CLDN15 OriGene siRNA: CLDN15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN15

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN15 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN15 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLDN15 (NM_014343)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN15

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN15 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CLDN15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN15

Additional cDNA sequence:

AJ245738.1 AK056103.1 BC010160.1

10 DOTS entries:

DT.110692 DT.91749561 DT.100000665 DT.91734186 DT.100746771 DT.97842928 DT.95260306 DT.100746769

DT.121126419 DT.95074538

24/325 AceView cDNA sequences (see all 325):

CR624091 N93442 BM764542 R49820 BF725321 BM852038 BM702115 AI803601

AK124705 BU689241 CB265853 AI299184 AI335895 BU557819 BI837319 AJ572607

BM764745 BG747893 BI828753 BM764727 BQ636092 BM805626 BC010160 AK056103

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN15 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b
SP1:					-		-						-				-		-
SP2:													-		-		-		-
SP3:							-
SP4:
SP5:

ECgene alternative splicing isoforms for CLDN15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLDN15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCTCCAG

About this image

CLDN15 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CLDN15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLDN15

SOURCE GeneReport for Unigene cluster: Hs.38738

SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN15:

Tight Junctions in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN15 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CLDN15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN15

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLDN15 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CLDN15⁶	--	59(a)	1 ↔ 1	GL343220.1(54398-63384)
zebrafish (Danio rerio)	Actinopterygii	zgc63943²	hypothetical protein MGC63943	73.77(n)		393375 BC054577.1

ENSEMBL Gene Tree for CLDN15 (if available)
TreeFam Gene Tree for CLDN15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CLDN15 gene

CLDN9² CLDN4² CLDN8² CLDN20² CLDN17² CLDN5² CLDN2² CLDN10²

CLDN3² CLDN1² CLDN14² CLDN6² CLDN7² CLDN19²

17 SIMAP similar genes for CLDN15 using alignment to 5 protein entries: CLD15_HUMAN (see all proteins):

CLDN7 CLDN10 CLDN18 CLDN19 CLDN20 CLDN1

CLDN3 CLDN6 CLDN4 CLDN5 CLDN2 CLDN8

CLDN9 CLDN14 CLDN22 CLDN24 CLDN17

CLDN15 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188867169^1,2		--	100874979(+)	`GAGAAA/GGTCTC`	2	--	ds500¹ int¹		0	--	--	--	--
rs181188715^1,2		--	100875040(+)	`CCTGAG/TAACCA`	2	--	int¹ ds500¹		0	--	--	--	--
rs56037105^1,2	C,	--	100875200(+)	`TCTTAC/ACAGCA`	2	--	ds500¹ int¹		2		WA	120
rs186231393^1,2		--	100875336(+)	`TCACCC/GCTTGC`	2	--	int¹ ds500¹		0	--	--	--	--
rs190503458^1,2		--	100875406(+)	`GAATGC/TATTTA`	2	--	ut3¹		0	--	--	--	--
rs200275514^1,2		--	100875542(+)	`CCATG-/AAGAGT`	2	--	ut3¹		0	--	--	--	--
rs183990374^1,2	C,	--	100875678(+)	`GCCCAC/TGGGCC`	2	--	ut3¹		0	--	--	--	--
rs200846307^1,2		--	100875757(+)	`GCGACA/GGGCAT`	4	P	syn¹		0	--	--	--	--
rs149925321^1,2	C,	--	100875770(+)	`CGGACA/GCTGGA`	4	A V	mis¹		0	--	--	--	--
rs1047319^1,2	C,F,A,H,	--	100875772(-)	`GCTCCA/CGTGTC`	4	P	syn¹ ese³		26		NA NS EA CSA WA EU	7856

HapMap Linkage Disequilibrium report for CLDN15 (100875373 - 100882101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CLDN15
3 CNVs: 5244 8576 5245

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN15

DNA2.0 Custom Variant and Variant Library Synthesis for CLDN15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLDN15 for disorders About GeneDecksing

6 diseases for CLDN15: About MalaCards

malignant peritoneal mesothelioma hepatitis c peritonitis colon cancer

hepatitis carcinoma

Export disorders for CLDN15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLDN15 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with CLDN15)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Ion transport and barrier function in a telomerase-im mortalized human nondysplastic, Barrett's cell line (BAR-T). (PubMed id 19673046)¹ Jovov B....Orlando R.C. (2009)
The claudins. (PubMed id 19706201)¹ Lal-Nag M. and Morin P.J. (2009)
Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. (PubMed id 19420749)¹ Takehara M....Mizushima T. (2009)
Structure and function of claudins. (PubMed id 18036336)¹ Krause G....Blasig I.E. (2008)
Claudins--key pieces in the tight junction puzzle. (PubMed id 16798613)¹ Koval M. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Tight junction proteins. (PubMed id 12475568)¹ Gonzalez-Mariscal L....Jaramillo B.E. (2003)
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. (PubMed id 13129853)¹ Van Itallie C.M....Anderson J.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 24146	HGNC: 2036	AceView: CLDN15andTTC11	Ensembl:ENSG00000106404	euGenes: HUgn24146
ECgene: CLDN15	Kegg: 24146	H-InvDB: CLDN15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLDN15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CLDN15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CLDN15 gene:
Search GeneIP for patents involving CLDN15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CLDN15
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN15		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN15
	OriGene Protein Over-expression Lysate for CLDN15		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CLDN15		OriGene 3'-UTR Clone for CLDN15
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN15		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN15
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CLDN15		OriGene Custom Protein Services for CLDN15
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN15
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN15
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN15
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN15
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN15
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN15

	GenScript Custom Purified and Recombinant Proteins Services for CLDN15		GenScript cDNA clones with any tag delivered in your preferred vector for CLDN15
	GenScript Custom Assay Services for CLDN15		GenScript Custom Superior Antibodies Services for CLDN15
	GenScript Custom overexpressing Cell Line Services for CLDN15		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CLDN15 promoter
	Search Chromatin IP Primers for CLDN15
	RT² qPCR Primer Assay in human, mouse, rat CLDN15
	Search GNC Networks for CLDN15
	SABiosciences PCR Arrays including human, mouse, rat CLDN15

Search Tocris compounds for CLDN15

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CLDN15 antibodies
	CLDN15 proteins
	CLDN15 lysates

	Search for Antibodies for CLDN15 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CLDN15
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CLDN15 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CLDN15

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN15

	SwitchGear 3'UTR luciferase reporter plasmids for CLDN15
	SwitchGear Promoter luciferase reporter plasmids for CLDN15

ThermoFisher Antibodies for CLDN15

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN15

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CLDN15 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CLDN15 Gene

claudin 15

Aliases
for CLDN15 gene

Summaries
for CLDN15 gene

Genomic Views
for CLDN15 gene

Proteins
for CLDN15 gene

Protein Domains /
Families
for CLDN15 gene

Function
for CLDN15 gene

Pathways & Interactions
for CLDN15 gene

Drugs & Compounds
for CLDN15 gene

Transcripts
for CLDN15 gene

Expression
for CLDN15 gene

Orthologs
for CLDN15 gene

Paralogs
for CLDN15 gene

Genomic Variants
for CLDN15 gene

Disorders / Diseases
for CLDN15 gene

Publications
for CLDN15 gene

External Searches for CLDN15 gene

Genome Databases showing CLDN15 gene

Other Databases showing CLDN15 gene

Specialized Databases showing CLDN15 gene

Intellectual Property
for CLDN15 gene

Products
for CLDN15 gene

View Random Gene

Advanced Search

Export list of displayed genes

CLDN15 Gene

claudin 15

Aliasesfor CLDN15 gene

Summariesfor CLDN15 gene

Genomic Viewsfor CLDN15 gene

Proteinsfor CLDN15 gene

Protein Domains /Familiesfor CLDN15 gene

Functionfor CLDN15 gene

Pathways & Interactionsfor CLDN15 gene

Drugs & Compoundsfor CLDN15 gene

Transcriptsfor CLDN15 gene

Expression for CLDN15 gene

Orthologsfor CLDN15 gene

Paralogsfor CLDN15 gene

Genomic Variantsfor CLDN15 gene

Disorders / Diseasesfor CLDN15 gene

Publicationsfor CLDN15 gene

External Searches for CLDN15 gene

Genome Databases showing CLDN15 gene

Other Databases showing CLDN15 gene

Specialized Databases showing CLDN15 gene

Intellectual Propertyfor CLDN15 gene

Productsfor CLDN15 gene

View Random Gene

Aliases
for CLDN15 gene

Summaries
for CLDN15 gene

Genomic Views
for CLDN15 gene

Proteins
for CLDN15 gene

Protein Domains /
Families
for CLDN15 gene

Function
for CLDN15 gene

Pathways & Interactions
for CLDN15 gene

Drugs & Compounds
for CLDN15 gene

Transcripts
for CLDN15 gene

Expression
for CLDN15 gene

Orthologs
for CLDN15 gene

Paralogs
for CLDN15 gene

Genomic Variants
for CLDN15 gene

Disorders / Diseases
for CLDN15 gene

Publications
for CLDN15 gene

Intellectual Property
for CLDN15 gene

Products
for CLDN15 gene