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CLDN15 Gene

protein-coding   GIFtS: 54
GCID: GC07M100875

Claudin 15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 151 2
claudin-152

External Ids:    HGNC: 20361   Entrez Gene: 241462   Ensembl: ENSG000001064047   UniProtKB: P567463   

Export aliases for CLDN15 gene to outside databases

Previous GC identifers: GC07M099358 GC07M100421 GC07M100435 GC07M100471 GC07M100662 GC07M095468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN15 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for CLDN15 Gene:
CLDN15 (claudin 15) is a protein-coding gene. Diseases associated with CLDN15 include malignant peritoneal mesothelioma, and peritonitis. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is ENSG00000262302.

UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN15 gene promoter:
         Max1   MAZR   NRSF form 1   NRSF form 2   Arnt   YY1   FOXO1a   Pax-4a   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN15 promoter sequence
   Search Chromatin IP Primers for CLDN15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

CLDN15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN15 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100875:  view genomic region     (about GC identifiers)

Start:
100,875,373 bp from pter      End:
100,882,101 bp from pter
Size:
6,729 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,233,760-100,240,488     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746 (See protein sequence)
Recommended Name: Claudin-15  
Size: 228 amino acids; 24356 Da
Secondary accessions: B3KPB5

Explore the universe of human proteins at neXtProt for CLDN15: NX_P56746

Explore proteomics data for CLDN15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055158.1  NP_001172009.1  

    ENSEMBL proteins: 
     ENSP00000308870   ENSP00000385300   ENSP00000405308   ENSP00000398418   ENSP00000390230  
    Reactome Protein details: P56746

    CLDN15 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CLDN15
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    Novus Biologicals CLDN15 Protein
    Novus Biologicals CLDN15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CLDN15

    CLDN15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    CLDN15 Assay Products:

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    Cloud-Clone Corp. ELISAs for CLDN15
    Cloud-Clone Corp. CLIAs for CLDN15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR008094 Claudin15

    Graphical View of Domain Structure for InterPro Entry P56746

    ProtoNet protein and cluster: P56746

    2 Blocks protein domains:
    IPB006187 Claudin family signature
    IPB008094 Claudin-15 signature


    UniProtKB/Swiss-Prot: CLD15_HUMAN, P56746
    Similarity: Belongs to the claudin family


    CLDN15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD15_HUMAN, P56746
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Genatlas biochemistry entry for CLDN15:
    claudin 15,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,expressed in colon,fetal liver,spleen,breast

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--
         
    CLDN15 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cldn15):
     cellular  digestive/alimentary  endocrine/exocrine gland 

    CLDN15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cldn15tm1Sats for CLDN15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN15

    miRNA
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    Block miRNA regulation of human, mouse, rat CLDN15 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidCLDN15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN15

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    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN15 (NM_014343)
    Sino Biological Human cDNA Clone for CLDN15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN15

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD15_HUMAN, P56746: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--

    CLDN15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN15 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Tight junction
    Tight junction
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN15
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes


    1 Reactome Pathway for CLDN15
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN15):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN15 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN15: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CLDN15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN15 (ENSP000003088704) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN12ENSP000002879164STRING: ENSP00000287916
    CLDN14ENSP000003392924STRING: ENSP00000339292
    CLDN17ENSP000002868084STRING: ENSP00000286808
    CLDN18ENSP000001836054STRING: ENSP00000183605
    CLDN20ENSP000003561334STRING: ENSP00000356133
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--

    CLDN15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN15 (CLD15)

    1 HMDB Compound for CLDN15    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLDN15 gene (3 alternative transcripts): 
    NM_014343.2  NM_138429.1  NM_001185080.1  

    Unigene Cluster for CLDN15:

    Claudin 15
    Hs.38738  [show with all ESTs]
    Unigene Representative Sequence: NM_001185080
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308344(uc003uyg.2) ENST00000401528(uc003uyh.2) ENST00000433833
    ENST00000414035 ENST00000412417 ENST00000463331(uc003uyi.3 uc022aja.1)
    ENST00000433422
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLDN15 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLDN15
    SwitchGear 3'UTR luciferase reporter plasmidCLDN15 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN15
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    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN15 (NM_014343)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN15
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN15
      QuantiTect SYBR Green Assays in human, mouse, rat CLDN15
      QuantiFast Probe-based Assays in human, mouse, rat CLDN15

    Additional mRNA sequence: 

    AJ245738.1 AK056103.1 BC010160.1 

    10 DOTS entries:

    DT.110692  DT.91749561  DT.100000665  DT.91734186  DT.100746771  DT.97842928  DT.95260306  DT.100746769 
    DT.121126419  DT.95074538 

    Selected AceView cDNA sequences (see all 325):

    BM013902 AI346607 BQ695317 BG574364 BI225269 BF725321 H95941 BM781700 
    BI488904 BM772719 AI961636 BE302867 BC009428 BF507959 BM744462 BX506030 
    CB119317 AA436345 AA454862 AA181312 AW611664 R49820 N93442 BM997988 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
    SP1:              -     -                 -           -     -                                 
    SP2:                                      -     -     -     -                                 
    SP3:                    -                                                                     
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CLDN15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCTCCAG
    CLDN15 Expression
    About this image

    CLDN15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38738
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN15: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN15 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn151 , 5 claudin 151, 5 82.38(n)1
    78.41(a)1
      5 (76.07 cM)5
    603631  NM_021719.41  NP_068365.11 
     1369666165 
    chicken
    (Gallus gallus)
    Aves CLDN156
    claudin 15
    36(a)
    1 ↔ 1
    9(2183674-2204182) ENSGALG00000025857
    lizard
    (Anolis carolinensis)
    Reptilia CLDN156
    claudin 15
    61(a)
    1 ↔ 1
    GL343220.1(54351-65134)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cldn15.11 claudin 15, gene 1 61.19(n)
    58.67(a)
      100124975  NM_001102909.1  NP_001096379.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639432 hypothetical protein MGC63943 73.77(n)   393375  BC054577.1 


    ENSEMBL Gene Tree for CLDN15 (if available)
    TreeFam Gene Tree for CLDN15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN15 gene
    ENSG000002623022  CLDN102  CLDN182  CLDN252  CLDN242  CLDN222  
    17 SIMAP similar genes for CLDN15 using alignment to 5 protein entries:     CLD15_HUMAN (see all proteins):
    CLDN7    CLDN10    CLDN18    CLDN19    CLDN20    CLDN1
    CLDN3    CLDN4    CLDN5    CLDN2    CLDN6    CLDN8
    CLDN9    CLDN14    CLDN22    CLDN24    CLDN17

    CLDN15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN15 (see all 168)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888671691,2
    C--100874979(+) GAGAAA/GGTCTC 2 -- ds5001 int10--------
    rs1811887151,2
    --100875040(+) CCTGAG/TAACCA 2 -- ds5001 int10--------
    rs560371051,2
    C,F--100875200(+) TCTTAC/ACAGCA 2 -- ds5001 int12Minor allele frequency- A:0.11WA 120
    rs1862313931,2
    --100875336(+) TCACCC/GCTTGC 2 -- ds5001 int10--------
    rs1905034581,2
    --100875406(+) GAATGC/TATTTA 2 -- ut310--------
    rs2002755141,2
    --100875542(+) CCATG-/AAGAGT 2 -- ut310--------
    rs1839903741,2
    C--100875678(+) GCCCAC/TGGGCC 2 -- ut310--------
    rs2008463071,2
    --100875757(+) GCGACA/GGGCAT 4 P syn10--------
    rs1499253211,2
    C--100875770(+) CGGACA/GCTGGA 4 A V mis10--------
    rs10473191,2
    C,F,A,H--100875772(-) GCTCCA/CGTGTC 4 P syn1 ese326Minor allele frequency- C:0.22NA NS EA CSA WA EU 7856

    HapMap Linkage Disequilibrium report for CLDN15 (100875373 - 100882101 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CLDN15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2422376CNV Duplication17116639
    esv2422326CNV Duplication17116639
    nsv5875CNV Insertion18451855
    nsv831075CNV Loss17160897
    nsv831076CNV Loss17160897
    nsv831077CNV Loss17160897
    dgv7409n71CNV Loss21882294
    dgv7410n71CNV Loss21882294
    esv2752134CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN15
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for CLDN15:    
    About MalaCards
    malignant peritoneal mesothelioma    peritonitis    endotheliitis    hepatitis c
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CLDN15:
    Malignant peritoneal mesothelioma

    CLDN15 for disorders           About GeneDecksing


    Export disorders for CLDN15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN15 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with CLDN15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Impact of ancestry and common genetic variants on QT interval in African Americans. (PubMed id 23166209)1 Smith J.G....Newton-Cheh C. (Circ Cardiovasc Genet 2012)
    3. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    4. Ion transport and barrier function in a telomerase-immortalized human nondysplastic, Barrett's cell line (BAR-T). (PubMed id 19673046)1 Jovov B....Orlando R.C. (Dis. Esophagus 2009)
    5. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (Genome Biol. 2009)
    6. Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. (PubMed id 19420749)1 Takehara M....Mizushima T. (amp 2009)
    7. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (Biochim. Biophys. Acta 2008)
    8. Claudins--key pieces in the tight junction puzzle. (PubMed id 16798613)1 Koval M. (amp 2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Tight junction proteins. (PubMed id 12475568)1 GonzA!lez-Mariscal L....Jaramillo B.E. (Prog. Biophys. Mol. Biol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 24146 HGNC: 2036 AceView: CLDN15andTTC11 Ensembl:ENSG00000106404 euGenes: HUgn24146
    ECgene: CLDN15 Kegg: 24146 H-InvDB: CLDN15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLDN15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLDN15 gene:
    Search GeneIP for patents involving CLDN15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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