Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLDN15 Gene

Aliases for CLDN15 Gene

  • Claudin 15 2 3 5

External Ids for CLDN15 Gene

Previous GeneCards Identifiers for CLDN15 Gene

  • GC07M099358
  • GC07M100421
  • GC07M100435
  • GC07M100471
  • GC07M100662
  • GC07M100875
  • GC07M095468

Summaries for CLDN15 Gene

Entrez Gene Summary for CLDN15 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN15 Gene

CLDN15 (Claudin 15) is a Protein Coding gene. Diseases associated with CLDN15 include Malignant Peritoneal Mesothelioma. Among its related pathways are Cell junction organization and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN18.

UniProtKB/Swiss-Prot for CLDN15 Gene

  • Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.

Gene Wiki entry for CLDN15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN15 Gene

Genomics for CLDN15 Gene

Regulatory Elements for CLDN15 Gene

Enhancers for CLDN15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLDN15 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDN15 Gene

Chromosome:
7
Start:
101,232,092 bp from pter
End:
101,238,820 bp from pter
Size:
6,729 bases
Orientation:
Minus strand

Genomic View for CLDN15 Gene

Genes around CLDN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN15 Gene

Proteins for CLDN15 Gene

  • Protein details for CLDN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56746-CLD15_HUMAN
    Recommended name:
    Claudin-15
    Protein Accession:
    P56746
    Secondary Accessions:
    • B3KPB5

    Protein attributes for CLDN15 Gene

    Size:
    228 amino acids
    Molecular mass:
    24356 Da
    Quaternary structure:
    • Can form linear homooligomers in the membrane, giving rise to tight junction strand-like structures.

neXtProt entry for CLDN15 Gene

Proteomics data for CLDN15 Gene at MOPED

Post-translational modifications for CLDN15 Gene

Other Protein References for CLDN15 Gene

Antibody Products

No data available for DME Specific Peptides for CLDN15 Gene

Domains & Families for CLDN15 Gene

Gene Families for CLDN15 Gene

Protein Domains for CLDN15 Gene

Suggested Antigen Peptide Sequences for CLDN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56746

UniProtKB/Swiss-Prot:

CLD15_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN15: view

Function for CLDN15 Gene

Molecular function for CLDN15 Gene

GENATLAS Biochemistry:
claudin 15,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,expressed in colon,fetal liver,spleen,breast
UniProtKB/Swiss-Prot Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.
genes like me logo Genes that share phenotypes with CLDN15: view

Animal Models for CLDN15 Gene

MGI Knock Outs for CLDN15:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN15 Gene

Localization for CLDN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN15 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN15 Gene COMPARTMENTS Subcellular localization image for CLDN15 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN15: view

Pathways & Interactions for CLDN15 Gene

genes like me logo Genes that share pathways with CLDN15: view

Interacting Proteins for CLDN15 Gene

Gene Ontology (GO) - Biological Process for CLDN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034329 cell junction assembly TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN15: view

No data available for SIGNOR curated interactions for CLDN15 Gene

Drugs & Compounds for CLDN15 Gene

(1) Drugs for CLDN15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLDN15: view

Transcripts for CLDN15 Gene

Unigene Clusters for CLDN15 Gene

Claudin 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for CLDN15 Gene

GeneLoc Exon Structure for
CLDN15
ECgene alternative splicing isoforms for
CLDN15

Expression for CLDN15 Gene

mRNA expression in normal human tissues for CLDN15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.0).

SOURCE GeneReport for Unigene cluster for CLDN15 Gene Hs.38738

mRNA Expression by UniProt/SwissProt for CLDN15 Gene

P56746-CLD15_HUMAN
Tissue specificity: Detected in colon (at protein level).
genes like me logo Genes that share expression patterns with CLDN15: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CLDN15 Gene

Orthologs for CLDN15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDN15 35
  • 86.4 (n)
  • 82.02 (a)
CLDN15 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn15 35
  • 82.38 (n)
  • 78.41 (a)
Cldn15 16
Cldn15 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDN15 35
  • 98.83 (n)
  • 99.12 (a)
CLDN15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn15 35
  • 81.64 (n)
  • 78.85 (a)
dog
(Canis familiaris)
Mammalia CLDN15 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLDN15 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLDN15 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN15 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN15 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn15.1 35
  • 61.19 (n)
  • 58.67 (a)
zebrafish
(Danio rerio)
Actinopterygii cldn15b 35
  • 55.19 (n)
  • 49.18 (a)
zgc63943 35
CLDN15 (2 of 4) 36
  • 28 (a)
OneToMany
CLDN15 (4 of 4) 36
  • 28 (a)
OneToMany
cldn15a 36
  • 46 (a)
OneToMany
cldn15b 36
  • 41 (a)
OneToMany
Species with no ortholog for CLDN15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN15 Gene

ENSEMBL:
Gene Tree for CLDN15 (if available)
TreeFam:
Gene Tree for CLDN15 (if available)

Paralogs for CLDN15 Gene

Paralogs for CLDN15 Gene

genes like me logo Genes that share paralogs with CLDN15: view

Variants for CLDN15 Gene

Sequence variations from dbSNP and Humsavar for CLDN15 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1047319 -- 101,232,491(-) GCTCC(A/C)GTGTC reference, synonymous-codon
rs17135342 -- 101,232,276(-) GGCCC(C/G)GTGTC utr-variant-3-prime
rs17135348 -- 101,237,799(+) CAGAG(A/G)AATGA utr-variant-5-prime
rs28429010 -- 101,236,769(+) CCTTA(C/G)AGCGG intron-variant
rs2302428 -- 101,234,175(+) GGAGG(C/T)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN15 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
dgv7409n71 CNV Loss 21882294
esv2752134 CNV Gain 17911159
nsv831076 CNV Loss 17160897
dgv7410n71 CNV Loss 21882294
esv2422326 CNV Duplication 17116639
nsv5875 CNV Insertion 18451855
nsv831077 CNV Loss 17160897

Variation tolerance for CLDN15 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLDN15 Gene

Disorders for CLDN15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLDN15 Gene - From: GeneCards

Disorder Aliases PubMed IDs
malignant peritoneal mesothelioma
  • malignant mesothelioma of peritoneum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLDN15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN15
genes like me logo Genes that share disorders with CLDN15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN15 Gene

Publications for CLDN15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Impact of ancestry and common genetic variants on QT interval in African Americans. (PMID: 23166209) Smith J.G. … Newton-Cheh C. (Circ Cardiovasc Genet 2012) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibility. (PMID: 20188437) Inai T. … Shibata Y. (Eur. J. Cell Biol. 2010) 23
  5. Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. (PMID: 19420749) Takehara M. … Mizushima T. (Biol. Pharm. Bull. 2009) 3

Products for CLDN15 Gene

Sources for CLDN15 Gene

Content