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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN14 Gene

protein-coding   GIFtS: 65
GCID: GC21M037832

claudin 14


(Previous symbol: DFNB29)
 Explore 6 diseases affiliated with
CLDN14 via our new
 Human Malady Compendium 
Biological research products
for CLDN14
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Claudin 141 2
DFNB291 2 5
Human CLDN14 Gene11
Claudin-141

External Ids:    HGNC: 20351   Entrez Gene: 235622   Ensembl: ENSG000001592617   OMIM: 6056085   UniProtKB: O955003   

Export aliases for CLDN14 gene to outside databases

Previous GC identifers: GC21M034410 GC21M036753 GC21M036754 GC21M023308


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN14:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. These junctions are comprised of sets of continuous networking strands in the
outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The
protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight
junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in
this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported
that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CLD14_HUMAN, O95500
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN14


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN14 gene promoter:
         GR   AML1a   c-Ets-1   FOXO1a   Chx10   ZID   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN14 promoter sequence

   Search SABiosciences Chromatin IP Primers for CLDN14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.13   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.13
CLDN14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN14 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M037832:   GeneLoc Nature:405,311-319
Start:
37,832,919 bp from pter       23,409,717 bp from centromere
End:
37,948,867 bp from pter 23,410,436 bp from centromere
Size:
115,949 bases 720 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AJ132445
genomic clones: KB5G11 KB176G8


(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLD14_HUMAN, O95500 (See protein sequence)
Recommended Name: Claudin-14  
Size: 239 amino acids; 25699 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for CLDN14: NX_O95500

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95500

  • CLDN14 Protein expression data from MOPED and PaxDb:    About this image 
    CLDN14 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001139549.1  NP_001139550.1  NP_001139551.1  NP_036262.1  NP_652763.1  

    ENSEMBL proteins: 
     ENSP00000382092   ENSP00000382090   ENSP00000382087   ENSP00000382088   ENSP00000339292  
    Reactome Protein details: O95500
    Human Recombinant Protein Products for CLDN14: 
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    Novus Biologicals CLDN14 Proteins
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    Uscn Proteins for CLDN14

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA16780588
    GO:0005886plasma membrane IDA16780588
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--

    CLDN14 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLDN14 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR003556 Claudin14
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O95500

    ProtoNet protein and cluster: O95500

    2 Blocks protein families:
    IPB003556 Claudin-14 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD14_HUMAN, O95500
    Similarity: Belongs to the claudin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD14_HUMAN, O95500
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Genatlas biochemistry entry for CLDN14:
    claudin 14,clostridium perfringens enterotoxin receptor-like,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--
         
    CLDN14 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CLDN14:
     Cell cycle / mitosis defect  Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Increased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cldn14):
     behavior/neurological  hearing/vestibular/ear  nervous system 

    CLDN14 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Cldn14tm1Lex for CLDN14
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLDN14 

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    SwitchGear 3'UTR luciferase reporter plasmidCLDN14 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    Cell-cell junction organization1.00
    Tight junction interactions0.49
    Cell junction organization0.69
    Cell-Cell communication0.45
    2Cell adhesion Tight junctions
    Cell adhesion Tight junctions1.00
    Cell adhesion_Tight junctions0.99
    3Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms1.00
    Cell adhesion_Endothelial cell contacts by junctional mechanisms0.97
    4Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics1.00
    Epithelial Tight Junctions0.36
    5Hepatitis C
    Hepatitis C1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CLDN14
        Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN14
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for CLDN14
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN14
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN14):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for CLDN14 (ENSP000003392924) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN12ENSP000002879164STRING: ENSP00000287916
    CLDN15ENSP000003088704STRING: ENSP00000308870
    CLDN17ENSP000002868084STRING: ENSP00000286808
    CLDN18ENSP000001836054STRING: ENSP00000183605
    CLDN20ENSP000003561334STRING: ENSP00000356133
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS7644498
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--

    CLDN14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN14

    1 HMDB Compound for CLDN14    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CLDN14 / CLD14 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN14 gene (5 alternative transcripts): 
    NM_001146077.1  NM_001146078.2  NM_001146079.1  NM_012130.3  NM_144492.2  

    Unigene Cluster for CLDN14:

    Claudin 14
    Hs.660278  [show with all ESTs]
    Unigene Representative Sequence: NM_144492
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399139(uc002yvk.1) ENST00000399137(uc002yvl.1) ENST00000399135(uc002yvm.1)
    ENST00000399136(uc002yvn.1) ENST00000342108(uc002yvo.1) ENST00000478313


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    hsa-miR-9 hsa-miR-23b hsa-miR-130a* hsa-miR-374b hsa-miR-23a hsa-miR-374a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCLDN14 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF314090.1 AJ566765.1 AJ566766.1 AY355348.1 AY355349.1 AY358533.1 BC012126.1 

    3 DOTS entries:

    DT.91828499  DT.97836433  DT.100736513 

    23 AceView cDNA sequences:

    BC012126 AY355349 BM911659 NM_012130 AJ566765 AY358533 AJ566766 AY355348 
    NM_144492 AW471454 CD624232 AF314090 BQ056804 BV197190 BV198315 BX101474 
    CD624233 BM559307 BG491506 CD624236 AI655909 CD636896 BG491911 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN14 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:        -     -     -           -     -     -         
    SP2:                    -           -     -     -         
    SP3:                                            -         
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for CLDN14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTTTGAGA
    CLDN14 Expression
    About this image
    See CLDN14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN14

    SOURCE GeneReport for Unigene cluster: Hs.660278

    UniProtKB/Swiss-Prot: CLD14_HUMAN, O95500
    Tissue specificity: Liver, kidney. Also found in ear

        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN14: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN14 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CLDN141 claudin 14 71.63(n)
    72.34(a)
      427982  XM_425552.2  XP_425552.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN146
    --
    72(a)
    1 ↔ 1
    3(141402322-141403029)
    zebrafish
    (Danio rerio)
    Actinopterygii cldn21 claudin 2 58.99(n)
    49.13(a)
      562525  NM_001004559.2  NP_001004559.2 


    ENSEMBL Gene Tree for CLDN14 (if available)
    TreeFam Gene Tree for CLDN14 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN14 gene
    CLDN92  CLDN42  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN102  
    CLDN152  CLDN32  CLDN12  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN14 using alignment to 1 protein entry:     CLD14_HUMAN:
    CLDN7    CLDN2    CLDN4    CLDN19    CLDN9    CLDN1
    CLDN8    CLDN20    CLDN3    CLDN6    CLDN10    CLDN5
    CLDN18    CLDN24    CLDN17    CLDN22    CLDN15    CLDN25

    CLDN14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2398 NCBI SNPs in CLDN14 are shown (see all 2398    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743154381,2
    Cpathogenic37833693(-) TCATCA/GGGATG 10 R G mis10--------
    rs743154371,2
    Cpathogenic37833740(-) CATGGA/TCATCT 10 D V mis10--------
    rs1880151471,2
    --37832518(+) CCCAAA/TGTGCT 5 -- int1 ds50010--------
    rs1384571611,2
    C--37832573(+) TCTTG-/TTTTTT 5 -- int1 ds50010--------
    rs2197811,2
    C,F,A,H--37832621(-) GGACGC/ATGTTT 5 -- int1 ds500119Minor allele frequency- A:0.23NS EA NA CSA WA 2219
    rs1167244011,2
    F--37832654(+) TGTCTT/GTTTCC 5 -- ds5001 int11Minor allele frequency- G:0.03WA 118
    rs1511316951,2
    C--37832663(+) CGAGG-/AAAGCC 5 -- int1 ds50010--------
    rs1429866971,2
    --37832699(+) TTCAAC/GCCGGG 5 -- ds5001 int10--------
    rs1474917581,2
    --37832728(+) TCAAGC/TGTCTT 5 -- ds5001 int10--------
    rs743164011,2
    C,F--37832766(+) CCAACG/ATCCCC 5 -- ds5001 int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CLDN14 (37832919 - 37948867 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for CLDN14
         6 CNVs: 90770 7323 103086 79344 73632 79343
         2 Indels: 46162 61975
    Human Gene Mutation Database (HGMD): CLDN14

    Locus Specific Mutation Databases (LSDB): CLDN14

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLDN14 for disorders           About GeneDecksing

    OMIM gene information: 605608    OMIM disorders: --

    UniProtKB/Swiss-Prot: CLD14_HUMAN, O95500
  • Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29) [MIM:614035]. DFNB29 is a
  • form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner
    ear, the nerve pathways to the brain, or the area of the brain that receives sound information

    6 diseases for CLDN14:    About MalaCards
    deafness, autosomal recessive 29    hearing loss    nephrolithiasis    hepatitis c
    tonsillitis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CLDN14:
    Nephrolithiasis     Nonsyndromic deafness
    Human Genome Epidemiology (HuGE) Navigator: CLDN14 (3 documents)

    Export disorders for CLDN14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN14 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CLDN14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. (PubMed id 11163249)1, 2, 3 Wilcox E.R.... Friedman T.B. (2001)
    2. Frequencies of gap- and tight-junction mutations in Turkish families with autosomal-recessive non-syndromic hearing loss. (PubMed id 12791041)1, 2, 9 Uyguner O.... Wollnik B. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. (PubMed id 15880785)1, 9 Wattenhofer M....Antonarakis S.E. (2005)
    7. Palmitoylation of claudins is required for efficient tight-junction localization. (PubMed id 15769849)1, 9 Van Itallie C.M....Anderson J.M. (2005)
    8. Novel CLDN14 mutations in Pakistani families with auto somal recessive non-syndromic hearing loss. (PubMed id 22246673)1 Lee K....Leal S.M. (2012)
    9. Mutations in CLDN14 are associated with different hea ring thresholds. (PubMed id 20811388)1 Bashir R....Naz S. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23562 HGNC: 2035 AceView: CLDN14 Ensembl:ENSG00000159261 euGenes: HUgn23562
    ECgene: CLDN14 Kegg: 23562 H-InvDB: CLDN14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN14 gene:
    Search GeneIP for patents involving CLDN14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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