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Aliases for CLDN12 Gene

Aliases for CLDN12 Gene

  • Claudin 12 2 3
  • Claudin-12 3
  • CLKDN12 6

External Ids for CLDN12 Gene

Summaries for CLDN12 Gene

Entrez Gene Summary for CLDN12 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]

GeneCards Summary for CLDN12 Gene

CLDN12 (Claudin 12) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity.

UniProtKB/Swiss-Prot for CLDN12 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN12 Gene

Genomics for CLDN12 Gene

Genomic Location for CLDN12 Gene

90,383,721 bp from pter
90,513,402 bp from pter
129,682 bases
Plus strand

Genomic View for CLDN12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN12 Gene

Regulatory Elements for CLDN12 Gene

Proteins for CLDN12 Gene

  • Protein details for CLDN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D6W5Q4
    • Q7LDZ0

    Protein attributes for CLDN12 Gene

    244 amino acids
    Molecular mass:
    27110 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN12 Gene

Proteomics data for CLDN12 Gene at MOPED

Post-translational modifications for CLDN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN12 Gene

No data available for DME Specific Peptides for CLDN12 Gene

Domains for CLDN12 Gene

Gene Families for CLDN12 Gene


Protein Domains for CLDN12 Gene


Suggested Antigen Peptide Sequences for CLDN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.:
    • P56749
genes like me logo Genes that share domains with CLDN12: view

Function for CLDN12 Gene

Molecular function for CLDN12 Gene

GENATLAS Biochemistry: claudin 12,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands
UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN12: view

miRNA for CLDN12 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLDN12 Gene

Localization for CLDN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN12 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLDN12 Gene COMPARTMENTS Subcellular localization image for CLDN12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
GO:0016328 lateral plasma membrane IEA --
GO:0071944 cell periphery --
genes like me logo Genes that share ontologies with CLDN12: view

Pathways for CLDN12 Gene

genes like me logo Genes that share pathways with CLDN12: view

Interacting Proteins for CLDN12 Gene

Gene Ontology (GO) - Biological Process for CLDN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0034329 cell junction assembly TAS --
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN12: view

Compounds for CLDN12 Gene

(1) HMDB Compounds for CLDN12 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CLDN12: view

Transcripts for CLDN12 Gene

Unigene Clusters for CLDN12 Gene

Claudin 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - -
SP8: - - -

Relevant External Links for CLDN12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN12 Gene

mRNA expression in normal human tissues for CLDN12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLDN12 Gene

SOURCE GeneReport for Unigene cluster for CLDN12 Gene Hs.731917

genes like me logo Genes that share expressions with CLDN12: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLDN12 Gene

Orthologs for CLDN12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLDN12 35
  • 99.73 (n)
  • 100 (a)
CLDN12 36
  • 100 (a)
(Bos Taurus)
Mammalia CLDN12 35
  • 89.07 (n)
  • 95.08 (a)
CLDN12 36
  • 95 (a)
(Canis familiaris)
Mammalia CLDN12 35
  • 93.44 (n)
  • 97.13 (a)
CLDN12 36
  • 97 (a)
(Mus musculus)
Mammalia Cldn12 35
  • 87.43 (n)
  • 91.39 (a)
Cldn12 16
Cldn12 36
  • 91 (a)
(Monodelphis domestica)
Mammalia CLDN12 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Cldn12 35
  • 87.57 (n)
  • 92.62 (a)
(Gallus gallus)
Aves CLDN12 35
  • 73.22 (n)
  • 77.87 (a)
CLDN12 36
  • 78 (a)
(Anolis carolinensis)
Reptilia CLDN12 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn12 35
  • 69.55 (n)
  • 67.08 (a)
Str.7430 35
(Danio rerio)
Actinopterygii cldn12 35
  • 58 (n)
  • 55.16 (a)
cldn12 36
  • 39 (a)
Species with no ortholog for CLDN12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN12 Gene

Gene Tree for CLDN12 (if available)
Gene Tree for CLDN12 (if available)

Paralogs for CLDN12 Gene

No data available for Paralogs for CLDN12 Gene

Variants for CLDN12 Gene

Sequence variations from dbSNP and Humsavar for CLDN12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9731 -- 90,415,631(-) TTGGA(C/T)GGCTT utr-variant-3-prime
rs917660 -- 90,403,618(+) AAAAT(A/G)GCTAA intron-variant
rs1017104 -- 90,413,868(+) AGTCA(A/G)TAATC utr-variant-3-prime
rs1017105 -- 90,413,990(+) TAAAA(C/T)GTATT utr-variant-3-prime
rs1048881 -- 90,415,243(+) TTTTN(C/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLDN12 Gene

Variant ID Type Subtype PubMed ID
nsv888709 CNV Gain 21882294
esv24241 CNV Loss 19812545

Relevant External Links for CLDN12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN12 Gene

Disorders for CLDN12 Gene

Relevant External Links for CLDN12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLDN12: view

No data available for UniProtKB/Swiss-Prot for CLDN12 Gene

Publications for CLDN12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. (PMID: 14698084) Kitajiri S.I. … Tsukita S. (Hear. Res. 2004) 3

Products for CLDN12 Gene

Sources for CLDN12 Gene

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