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Aliases for CLDN12 Gene

Aliases for CLDN12 Gene

  • Claudin 12 2 3 5

External Ids for CLDN12 Gene

Previous GeneCards Identifiers for CLDN12 Gene

  • GC07P088568
  • GC07P089630
  • GC07P089644
  • GC07P089677
  • GC07P089871
  • GC07P090013
  • GC07P084642

Summaries for CLDN12 Gene

Entrez Gene Summary for CLDN12 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]

GeneCards Summary for CLDN12 Gene

CLDN12 (Claudin 12) is a Protein Coding gene. Among its related pathways are Cell junction organization and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include identical protein binding and structural molecule activity.

UniProtKB/Swiss-Prot for CLDN12 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN12 Gene

Genomics for CLDN12 Gene

Regulatory Elements for CLDN12 Gene

Enhancers for CLDN12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLDN12 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDN12 Gene

Chromosome:
7
Start:
90,383,721 bp from pter
End:
90,513,402 bp from pter
Size:
129,682 bases
Orientation:
Plus strand

Genomic View for CLDN12 Gene

Genes around CLDN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN12 Gene

Proteins for CLDN12 Gene

  • Protein details for CLDN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56749-CLD12_HUMAN
    Recommended name:
    Claudin-12
    Protein Accession:
    P56749
    Secondary Accessions:
    • D6W5Q4
    • Q7LDZ0

    Protein attributes for CLDN12 Gene

    Size:
    244 amino acids
    Molecular mass:
    27110 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN12 Gene

Proteomics data for CLDN12 Gene at MOPED

Post-translational modifications for CLDN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN12 Gene

Antibody Products

No data available for DME Specific Peptides for CLDN12 Gene

Domains & Families for CLDN12 Gene

Gene Families for CLDN12 Gene

Protein Domains for CLDN12 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLDN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56749

UniProtKB/Swiss-Prot:

CLD12_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN12: view

Function for CLDN12 Gene

Molecular function for CLDN12 Gene

GENATLAS Biochemistry:
claudin 12,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands
UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
genes like me logo Genes that share phenotypes with CLDN12: view

Animal Model Products

miRNA for CLDN12 Gene

miRTarBase miRNAs that target CLDN12

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDN12 Gene

Localization for CLDN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN12 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN12 Gene COMPARTMENTS Subcellular localization image for CLDN12 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CLDN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN12: view

Pathways & Interactions for CLDN12 Gene

genes like me logo Genes that share pathways with CLDN12: view

Interacting Proteins for CLDN12 Gene

Gene Ontology (GO) - Biological Process for CLDN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN12: view

No data available for SIGNOR curated interactions for CLDN12 Gene

Drugs & Compounds for CLDN12 Gene

(1) Drugs for CLDN12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLDN12: view

Transcripts for CLDN12 Gene

Unigene Clusters for CLDN12 Gene

Claudin 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - -
SP8: - - -

Relevant External Links for CLDN12 Gene

GeneLoc Exon Structure for
CLDN12
ECgene alternative splicing isoforms for
CLDN12

Expression for CLDN12 Gene

mRNA expression in normal human tissues for CLDN12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLDN12 Gene

This gene is overexpressed in Frontal cortex (39.0) and Retina (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CLDN12 Gene



SOURCE GeneReport for Unigene cluster for CLDN12 Gene Hs.731917

genes like me logo Genes that share expression patterns with CLDN12: view

Protein tissue co-expression partners for CLDN12 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLDN12 Gene

Orthologs for CLDN12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDN12 35
  • 89.07 (n)
  • 95.08 (a)
CLDN12 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN12 35
  • 93.44 (n)
  • 97.13 (a)
CLDN12 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn12 35
  • 87.43 (n)
  • 91.39 (a)
Cldn12 16
Cldn12 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDN12 35
  • 99.73 (n)
  • 100 (a)
CLDN12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn12 35
  • 87.57 (n)
  • 92.62 (a)
oppossum
(Monodelphis domestica)
Mammalia CLDN12 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN12 35
  • 73.22 (n)
  • 77.87 (a)
CLDN12 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN12 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn12 35
  • 69.55 (n)
  • 67.08 (a)
Str.7430 35
zebrafish
(Danio rerio)
Actinopterygii cldn12 35
  • 58 (n)
  • 55.16 (a)
cldn12 36
  • 39 (a)
OneToOne
Species with no ortholog for CLDN12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN12 Gene

ENSEMBL:
Gene Tree for CLDN12 (if available)
TreeFam:
Gene Tree for CLDN12 (if available)

Paralogs for CLDN12 Gene

No data available for Paralogs for CLDN12 Gene

Variants for CLDN12 Gene

Structural Variations from Database of Genomic Variants (DGV) for CLDN12 Gene

Variant ID Type Subtype PubMed ID
nsv888709 CNV Gain 21882294
esv24241 CNV Loss 19812545

Variation tolerance for CLDN12 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for CLDN12 Gene

Disorders for CLDN12 Gene

Relevant External Links for CLDN12

Genetic Association Database (GAD)
CLDN12
Human Genome Epidemiology (HuGE) Navigator
CLDN12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN12

No disorders were found for CLDN12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN12 Gene

Publications for CLDN12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Interleukin-18 enhances breast cancer cell migration via down-regulation of claudin-12 and induction of the p38 MAPK pathway. (PMID: 25727011) Yang Y. … Cho D. (Biochem. Biophys. Res. Commun. 2015) 3
  3. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Claudins in human cancer: a review. (PMID: 19924644) Ouban A. … Ahmed A.A. (Histol. Histopathol. 2010) 3

Products for CLDN12 Gene

Sources for CLDN12 Gene

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