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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN11 Gene

protein-coding   GIFtS: 60
GCID: GC03P170136

claudin 11

(Previous name: oligodendrocyte transmembrane protein )
(Previous symbol: OTM)
 Explore 17 diseases affiliated with
CLDN11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLDN11    

Aliases
for CLDN11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Claudin 111 2
OSP1 2 3 5
OTM1 2 3 5
Oligodendrocyte Transmembrane Protein1 2
Oligodendrocyte-Specific Protein2 3
Claudin-111

External Ids:    HGNC: 85141   Entrez Gene: 50102   Ensembl: ENSG000000132977   OMIM: 6013265   UniProtKB: O755083   

Export aliases for CLDN11 gene to outside databases

Previous GC identifers: GC03P167279 GC03P171185 GC03P171538 GC03P171457 GC03P171619 GC03P167506


Summaries
for CLDN11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN11:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely
through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in
maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central
nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes.
Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in
the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption
is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have
been identified.(provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: CLD11_HUMAN, O75508
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN11


Genomic Views
for CLDN11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN11 gene promoter:
         USF1   GATA-3   AML1a   Evi-1   GATA-1   GATA-2   CREB   deltaCREB   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2-q26.3   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2-q26.3

CLDN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P170136:  view genomic region     (about GC identifiers)

Start:
 170,136,653 bp from pter      End:
 170,578,169 bp from pter
Size:
 441,517 bases      Orientation:
 plus strand

Proteins
for CLDN11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD11_HUMAN, O75508 (See protein sequence)
Recommended Name: Claudin-11  
Size: 207 amino acids; 21993 Da
Subunit: Interacts with tetraspanin-3/TSPAN3 (By similarity)
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Secondary accessions: B2R7C1 D3DNQ5 Q5U0P3

Explore the universe of human proteins at neXtProt for CLDN11: NX_O75508

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75508

    • CLDN11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171985.1  NP_005593.2  

    ENSEMBL proteins: 
     ENSP00000064724   ENSP00000417434   ENSP00000410185  
    Reactome Protein details: O75508
    Human Recombinant Protein Products: 
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    Novus Biologicals CLDN11 Proteins
    Novus Biologicals CLDN11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN11

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--


    CLDN11 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for CLDN11

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    Uscn ELISAs and CLIAs for CLDN11

    Protein Domains /
    Families
    for CLDN11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN11 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR003555 Claudin11

    Graphical View of Domain Structure for InterPro Entry O75508

    ProtoNet protein and cluster: O75508

    2 Blocks protein families:
    IPB003555 Claudin-11 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD11_HUMAN, O75508
    Similarity: Belongs to the claudin family


    Function
    for CLDN11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD11_HUMAN, O75508
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN11
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN11 (see all 58):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN11 (see all 7)
    OriGene shRNA RFP: CLDN11
    OriGene siRNA: CLDN11
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN11 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLDN11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN11

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--


    CLDN11 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLDN11:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Cldn11tm1Sts for CLDN11
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cldn11):
     behavior/neurological  endocrine/exocrine gland  hearing/vestibular/ear  nervous system  reproductive system 
     vision/eye 

    CLDN11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    3Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    4Hepatitis C
    		Hepatitis C1.00
    5Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CLDN11
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN11
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN11
        Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN11
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN11):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for CLDN11 (O755083 ENSP000000647244) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSPAN4O148173, ENSP000003243044I2D: score=4 STRING: ENSP00000324304
    TSPAN3O606373, ENSP000002679704I2D: score=2 STRING: ENSP00000267970
    CSF1P096033I2D: score=1 
    ITGB1P055563I2D: score=1 
    CLDN1ENSP000002955224STRING: ENSP00000295522
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007283spermatogenesis IEA--
    GO:0008366axon ensheathment IEA--
    GO:0016338calcium-independent cell-cell adhesion ISS--


    CLDN11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLDN11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN11

    1 HMDB Compound for CLDN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for CLDN11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',3'-cyclic nucleotide 72.6 2 12730962 (1), 15765008 (1)

    Search CenterWatch for drugs/clinical trials and news about CLDN11 / CLD11 

    Transcripts
    for CLDN11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN11 gene (2 alternative transcripts): 
    NM_001185056.1  NM_005602.5  

    Unigene Cluster for CLDN11:

    Claudin 11
    Hs.31595  [show with all ESTs]
    Unigene Representative Sequence: AK098766
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000064724(uc003fgx.3) ENST00000486975(uc011bpt.1) ENST00000486429
    ENST00000489485(uc003fgy.3) ENST00000468358 ENST00000471373 ENST00000477531
    ENST00000488989 ENST00000480067(uc003fha.1) ENST00000451576

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CLDN11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN11
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN11 (see all 58):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN11 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN11 (see all 7)
    OriGene shRNA RFP: CLDN11
    OriGene siRNA: CLDN11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN11
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF085871.1 AJ245901.1 AJ245902.1 AK098766.1 AK294087.1 AK294108.1 AK312923.1 BC013577.1 
    BT019402.1 BT019403.1 

    5 DOTS entries:

    DT.113286  DT.100774485  DT.91924737  DT.95073966  DT.40289488 

    24/85 AceView cDNA sequences (see all 85):

    CK002146 AL040912 NM_005602 BX397382 H49448 D45304 CR595007 AW316877 
    BC013577 N22392 BX460243 AW264204 H18687 AW665439 AL040911 AJ245901 
    BP347739 BI599684 BM989755 BM989777 BM991873 H42158 AA364287 H42979 

    GeneLoc Exon Structure


    Expression
    for CLDN11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTTCCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    BoneAutopod Long BoneBone
    BrainMeningesBrain
    KidneyInterstitial StromaKidney
    LimbAutopodLimb
    LungTracheaLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
    Skeletal myocytes (Generation of skelet...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

    See CLDN11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN11

    SOURCE GeneReport for Unigene cluster: Hs.31595
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN11: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN11

    Orthologs
    for CLDN11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN11 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLDN111 claudin 11 82.29(n)
    85.02(a)    		   424990  XM_422797.3  XP_422797.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLDN116
    		 --
    		 83(a)
    		 1 ↔ 1
    		 3(7551309-7569831)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.124862 Transcribed sequence with weak similarity to protein more 75.2(n)    BI673109.1 


    ENSEMBL Gene Tree for CLDN11 (if available)
    TreeFam Gene Tree for CLDN11 (if available) 

    Paralogs
    for CLDN11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN11 gene
    CLDN162  
    7 SIMAP similar genes for CLDN11 using alignment to 2 protein entries:     CLD11_HUMAN (see all proteins):
    CLDN19    CLDN7    CLDN18    CLDN1    CLDN10    CLDN3
    CLDN9

    CLDN11 for paralogs           About GeneDecksing



    Genomic Variants
    for CLDN11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 NCBI SNPs in CLDN11 are shown (see all 301)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs792106321,2
    		F,--170134728(+) TTGCCG/ATTATG 1 -- us2k12Minor allele frequency- A:0.05NA EA 240
    rs2006873901,2
    		--170134788(+) TATGA-/GGTAGGT 1 -- us2k10--------
    rs716344741,2
    		C,--170134789(+) ATGAGGT/-AGGTA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1146513811,2
    		F,--170134800(+) ACAGTT/CTTCAT 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1869475341,2
    		--170134877(+) TGATGA/GAGCCA 1 -- us2k10--------
    rs1174400741,2
    		--170134952(+) CCCTTG/CTACTT 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs762191141,2
    		F,--170135076(+) GATTGC/TACTGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1886962691,2
    		--170135237(+) AGGGAA/GTGGAT 1 -- us2k10--------
    rs730383721,2
    		C,--170135538(+) CCCTTG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1160169511,2
    		--170135581(+) AGTTCG/ATGAAA 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for CLDN11 (170136653 - 170386653 bp, first 250kb of CLDN11)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLDN11: --

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    Disorders / Diseases
    for CLDN11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN11 for disorders           About GeneDecksing

    OMIM gene information: 601326    OMIM disorders: --

    17 diseases for CLDN11:    About MalaCards
    cocaine abuse    microcystic adenoma    lyme disease    horner's syndrome
    multiple sclerosis    papilloma    encephalomyelitis    shigellosis
    hepatitis c    crohn's disease    adenoma    choroiditis
    arthritis    gastric cancer    meningioma    hepatitis
    cholesterol

    1 disease from the University of Copenhagen DISEASES database for CLDN11:
    Horner's syndrome

    7 Novoseek disease relationships for CLDN11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lyme disease 64.5 1 8740122 (1)
    borreliosis 56.4 2 7664493 (2)
    demyelination 45.8 1 18412169 (1)
    multiple sclerosis 42.3 3 11746369 (1), 18412169 (1), 20236710 (1)
    encephalomyelitis 26.2 1 10358205 (1)
    neurological disorders 23 1 7664493 (1)
    arthritis 3.39 2 7685738 (1)


    Export disorders for CLDN11 gene to outside databases

    Publications
    for CLDN11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN11 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with CLDN11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. (PubMed id 10700007)1, 2, 9 Bronstein J.M.... Stevens D.B. (2000)
    2. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. (PubMed id 8661061)1, 3, 9 Bronstein J.M....Farber D.B. (1996)
    3. Isolation and characterization of a novel oligodendrocyte-specific protein. (PubMed id 8797478)1, 3, 9 Bronstein J.M....Farber D.B. (1996)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells. (PubMed id 19956721)1, 9 Agarwal R....Meltzer S.J. (2009)
    6. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. (PubMed id 19241088)1, 9 Fink C....Brehm R. (2009)
    7. Developmental expression of OSP/claudin-11. (PubMed id 10797530)1, 9 Bronstein J.M....Kornblum H.I. (2000)
    8. Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve. (PubMed id 18412169)1, 9 Bajramovic J.J....Ben-Nun A. (2008)
    9. Transcriptional profiling of human cavernosal endothe lial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function. (PubMed id 19622796)1, 9 Wessells H....Chitaley K. (2009)
    10. Expression of complement messenger RNAs and proteins by human oligodendroglial cells. (PubMed id 12730962)1, 9 Hosokawa M....McGeer P.L. (2003)

    External Searches for CLDN11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLDN11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5010 HGNC: 8514 AceView: CLDN11 Ensembl:ENSG00000013297 euGenes: HUgn5010
    ECgene: CLDN11 Kegg: 5010 H-InvDB: CLDN11

    Other Databases showing CLDN11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLDN11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLDN11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN11 gene:
    Search GeneIP for patents involving CLDN11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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