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Aliases for CLDN11 Gene

Aliases for CLDN11 Gene

  • Claudin 11 2 3
  • OTM 3 4 6
  • OSP 3 4 6
  • Oligodendrocyte Transmembrane Protein 2 3
  • Oligodendrocyte-Specific Protein 3 4
  • Claudin-11 3

External Ids for CLDN11 Gene

Previous Symbols for CLDN11 Gene

  • OTM

Summaries for CLDN11 Gene

Entrez Gene Summary for CLDN11 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN11 Gene

CLDN11 (Claudin 11) is a Protein Coding gene. Diseases associated with CLDN11 include microcystic adenoma. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity.

UniProtKB/Swiss-Prot for CLDN11 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN11 Gene

Genomics for CLDN11 Gene

Genomic Location for CLDN11 Gene

Start:
170,418,865 bp from pter
End:
170,860,380 bp from pter
Size:
441,516 bases
Orientation:
Plus strand

Genomic View for CLDN11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN11 Gene

Regulatory Elements for CLDN11 Gene

Proteins for CLDN11 Gene

  • Protein details for CLDN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75508-CLD11_HUMAN
    Recommended name:
    Claudin-11
    Protein Accession:
    O75508
    Secondary Accessions:
    • B2R7C1
    • D3DNQ5
    • Q5U0P3

    Protein attributes for CLDN11 Gene

    Size:
    207 amino acids
    Molecular mass:
    21993 Da
    Quaternary structure:
    • Interacts with tetraspanin-3/TSPAN3.

neXtProt entry for CLDN11 Gene

Proteomics data for CLDN11 Gene at MOPED

Post-translational modifications for CLDN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN11 Gene

Domains for CLDN11 Gene

Gene Families for CLDN11 Gene

HGNC:

Protein Domains for CLDN11 Gene

Suggested Antigen Peptide Sequences for CLDN11 Gene

Graphical View of Domain Structure for InterPro Entry

O75508

UniProtKB/Swiss-Prot:

CLD11_HUMAN
Family:
  • Belongs to the claudin family.:
    • O75508
genes like me logo Genes that share domains with CLDN11: view

Function for CLDN11 Gene

Molecular function for CLDN11 Gene

UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN11: view
genes like me logo Genes that share phenotypes with CLDN11: view

Animal Models for CLDN11 Gene

MGI Knock Outs for CLDN11:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CLDN11 Gene

Localization for CLDN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN11 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN11 Gene COMPARTMENTS Subcellular localization image for CLDN11 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
GO:0045178 basal part of cell IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLDN11: view

Pathways for CLDN11 Gene

genes like me logo Genes that share pathways with CLDN11: view

Gene Ontology (GO) - Biological Process for CLDN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007283 spermatogenesis IEA --
GO:0008366 axon ensheathment IEA --
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN11: view

Compounds for CLDN11 Gene

(1) HMDB Compounds for CLDN11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for CLDN11 Gene

Compound -log(P) Hits PubMed IDs
2,3-cyclic nucleotide 72.6 2
genes like me logo Genes that share compounds with CLDN11: view

Transcripts for CLDN11 Gene

Unigene Clusters for CLDN11 Gene

Claudin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN11 Gene

No ASD Table

Relevant External Links for CLDN11 Gene

GeneLoc Exon Structure for
CLDN11
ECgene alternative splicing isoforms for
CLDN11

Expression for CLDN11 Gene

mRNA expression in normal human tissues for CLDN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN11 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (10.2) and Brain - Substantia nigra (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLDN11 Gene

SOURCE GeneReport for Unigene cluster for CLDN11 Gene Hs.31595

genes like me logo Genes that share expressions with CLDN11: view

No data available for mRNA Expression by UniProt/SwissProt for CLDN11 Gene

Orthologs for CLDN11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN11 35
  • 99.36 (n)
  • 99.52 (a)
CLDN11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLDN11 35
  • 91.14 (n)
  • 95.65 (a)
CLDN11 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN11 35
  • 91.95 (n)
  • 96.62 (a)
CLDN11 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn11 35
  • 86.63 (n)
  • 94.2 (a)
Cldn11 16
Cldn11 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLDN11 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn11 35
  • 87.44 (n)
  • 94.2 (a)
chicken
(Gallus gallus)
Aves CLDN11 35
  • 82.29 (n)
  • 85.02 (a)
CLDN11 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN11 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn11 35
  • 70.05 (n)
  • 68.12 (a)
zebrafish
(Danio rerio)
Actinopterygii cldn11a 35
  • 61.51 (n)
  • 57.49 (a)
cldn11a 36
  • 54 (a)
OneToMany
cldn11b 36
  • 39 (a)
OneToMany
Dr.12486 35
Species with no ortholog for CLDN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN11 Gene

ENSEMBL:
Gene Tree for CLDN11 (if available)
TreeFam:
Gene Tree for CLDN11 (if available)

Paralogs for CLDN11 Gene

Selected SIMAP similar genes for CLDN11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN11: view

No data available for Paralogs for CLDN11 Gene

Variants for CLDN11 Gene

Sequence variations from dbSNP and Humsavar for CLDN11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13973 -- 170,433,903(+) TCCCC(C/T)ACTTT utr-variant-3-prime
rs2032744 -- 170,435,096(+) AATTA(C/T)AGGCG downstream-variant-500B
rs2052396 -- 170,417,113(+) ggcag(C/T)tggac upstream-variant-2KB
rs2422035 -- 170,427,484(+) GGCAT(A/G)GTGGC intron-variant
rs2422036 -- 170,427,569(+) tgagc(C/T)gagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN11 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855

Relevant External Links for CLDN11 Gene

HapMap Linkage Disequilibrium report
CLDN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN11 Gene

Disorders for CLDN11 Gene

(1) MalaCards Diseases for CLDN11 Gene

Search for CLDN11 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLDN11 Gene

(7) Novoseek inferred disease relationships for CLDN11 Gene

Disease -log(P) Hits PubMed IDs
lyme disease 64.5 1
borreliosis 56.4 2
demyelination 45.8 1
multiple sclerosis 42.3 3
encephalomyelitis 26.2 1

Relevant External Links for CLDN11

Genetic Association Database (GAD)
CLDN11
genes like me logo Genes that share disorders with CLDN11: view

No data available for UniProtKB/Swiss-Prot for CLDN11 Gene

Publications for CLDN11 Gene

  1. Isolation and characterization of a novel oligodendrocyte-specific protein. (PMID: 8797478) Bronstein J.M. … Farber D.B. (Neurology 1996) 2 3 23
  2. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. (PMID: 8661061) Bronstein J.M. … Farber D.B. (Genomics 1996) 2 3 23
  3. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. (PMID: 10700007) Bronstein J.M. … Stevens D.B. (J. Neurosci. Res. 2000) 3 4 23
  4. Expression of complement messenger RNAs and proteins by human oligodendroglial cells. (PMID: 12730962) Hosokawa M. … McGeer P.L. (Glia 2003) 3 23
  5. Developmental expression of OSP/claudin-11. (PMID: 10797530) Bronstein J.M. … Kornblum H.I. (J. Neurosci. Res. 2000) 3 23

Products for CLDN11 Gene

Sources for CLDN11 Gene

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