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Aliases for CLDN11 Gene

Aliases for CLDN11 Gene

  • Claudin 11 2 3 5
  • Oligodendrocyte Transmembrane Protein 2 3
  • Oligodendrocyte-Specific Protein 3 4
  • OTM 3 4
  • OSP 3 4

External Ids for CLDN11 Gene

Previous HGNC Symbols for CLDN11 Gene

  • OTM

Previous GeneCards Identifiers for CLDN11 Gene

  • GC03P167279
  • GC03P171185
  • GC03P171538
  • GC03P171457
  • GC03P171619
  • GC03P170136
  • GC03P167506

Summaries for CLDN11 Gene

Entrez Gene Summary for CLDN11 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN11 Gene

CLDN11 (Claudin 11) is a Protein Coding gene. Diseases associated with CLDN11 include lyme disease and appendiceal neoplasm. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include identical protein binding and structural molecule activity.

UniProtKB/Swiss-Prot for CLDN11 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN11 Gene

Genomics for CLDN11 Gene

Regulatory Elements for CLDN11 Gene

Promoters for CLDN11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLDN11 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDN11 Gene

Chromosome:
3
Start:
170,418,865 bp from pter
End:
170,860,380 bp from pter
Size:
441,516 bases
Orientation:
Plus strand

Genomic View for CLDN11 Gene

Genes around CLDN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN11 Gene

Proteins for CLDN11 Gene

  • Protein details for CLDN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75508-CLD11_HUMAN
    Recommended name:
    Claudin-11
    Protein Accession:
    O75508
    Secondary Accessions:
    • B2R7C1
    • D3DNQ5
    • Q5U0P3

    Protein attributes for CLDN11 Gene

    Size:
    207 amino acids
    Molecular mass:
    21993 Da
    Quaternary structure:
    • Interacts with tetraspanin-3/TSPAN3.

neXtProt entry for CLDN11 Gene

Proteomics data for CLDN11 Gene at MOPED

Post-translational modifications for CLDN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLDN11 Gene

Domains & Families for CLDN11 Gene

Gene Families for CLDN11 Gene

Protein Domains for CLDN11 Gene

Suggested Antigen Peptide Sequences for CLDN11 Gene

Graphical View of Domain Structure for InterPro Entry

O75508

UniProtKB/Swiss-Prot:

CLD11_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN11: view

Function for CLDN11 Gene

Molecular function for CLDN11 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
genes like me logo Genes that share phenotypes with CLDN11: view

Animal Models for CLDN11 Gene

MGI Knock Outs for CLDN11:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLDN11 Gene

Localization for CLDN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN11 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN11 Gene COMPARTMENTS Subcellular localization image for CLDN11 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CLDN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0045178 basal part of cell IEA --
genes like me logo Genes that share ontologies with CLDN11: view

Pathways & Interactions for CLDN11 Gene

genes like me logo Genes that share pathways with CLDN11: view

Gene Ontology (GO) - Biological Process for CLDN11 Gene

None

No data available for SIGNOR curated interactions for CLDN11 Gene

Drugs & Compounds for CLDN11 Gene

(1) Drugs for CLDN11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CLDN11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLDN11: view

Transcripts for CLDN11 Gene

Unigene Clusters for CLDN11 Gene

Claudin 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN11 Gene

No ASD Table

Relevant External Links for CLDN11 Gene

GeneLoc Exon Structure for
CLDN11
ECgene alternative splicing isoforms for
CLDN11

Expression for CLDN11 Gene

mRNA expression in normal human tissues for CLDN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN11 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.2) and Brain - Substantia nigra (x5.2).

Protein differential expression in normal tissues from HIPED for CLDN11 Gene

This gene is overexpressed in Frontal cortex (38.2) and Spinal cord (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLDN11 Gene



SOURCE GeneReport for Unigene cluster for CLDN11 Gene Hs.31595

genes like me logo Genes that share expression patterns with CLDN11: view

Protein tissue co-expression partners for CLDN11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CLDN11 Gene

Orthologs for CLDN11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDN11 35
  • 91.14 (n)
  • 95.65 (a)
CLDN11 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN11 35
  • 91.95 (n)
  • 96.62 (a)
CLDN11 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn11 35
  • 86.63 (n)
  • 94.2 (a)
Cldn11 16
Cldn11 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDN11 35
  • 99.36 (n)
  • 99.52 (a)
CLDN11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn11 35
  • 87.44 (n)
  • 94.2 (a)
oppossum
(Monodelphis domestica)
Mammalia CLDN11 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN11 35
  • 82.29 (n)
  • 85.02 (a)
CLDN11 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN11 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn11 35
  • 70.05 (n)
  • 68.12 (a)
zebrafish
(Danio rerio)
Actinopterygii cldn11a 35
  • 61.51 (n)
  • 57.49 (a)
Dr.12486 35
cldn11a 36
  • 54 (a)
OneToMany
cldn11b 36
  • 39 (a)
OneToMany
Species with no ortholog for CLDN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN11 Gene

ENSEMBL:
Gene Tree for CLDN11 (if available)
TreeFam:
Gene Tree for CLDN11 (if available)

Paralogs for CLDN11 Gene

(7) SIMAP similar genes for CLDN11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN11: view

No data available for Paralogs for CLDN11 Gene

Variants for CLDN11 Gene

Sequence variations from dbSNP and Humsavar for CLDN11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2422035 -- 170,427,484(+) GGCAT(A/G)GTGGC intron-variant
rs2422036 -- 170,427,569(+) tgagc(C/T)gagat intron-variant
rs4955724 -- 170,428,744(+) TAAAA(A/G)AGGAG intron-variant
rs6444928 -- 170,430,087(+) TGCCC(A/G)CAGCA intron-variant
rs6444929 -- 170,432,288(+) TTACA(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN11 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855

Variation tolerance for CLDN11 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN11 Gene

HapMap Linkage Disequilibrium report
CLDN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN11 Gene

Disorders for CLDN11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CLDN11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lyme disease
  • bannwarth syndrome
appendiceal neoplasm
  • appendix neoplasm
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLDN11

Genetic Association Database (GAD)
CLDN11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN11
genes like me logo Genes that share disorders with CLDN11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN11 Gene

Publications for CLDN11 Gene

  1. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. (PMID: 10700007) Bronstein J.M. … Stevens D.B. (J. Neurosci. Res. 2000) 3 4 23 67
  2. Isolation and characterization of a novel oligodendrocyte-specific protein. (PMID: 8797478) Bronstein J.M. … Farber D.B. (Neurology 1996) 2 3 23
  3. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. (PMID: 8661061) Bronstein J.M. … Farber D.B. (Genomics 1996) 2 3 23
  4. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. (PMID: 19241088) Fink C. … Brehm R. (Histochem. Cell Biol. 2009) 3 23
  5. Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function. (PMID: 19622796) Wessells H. … Chitaley K. (Physiol. Genomics 2009) 3 23

Products for CLDN11 Gene

Sources for CLDN11 Gene

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