Aliases for CLDN11 Gene
External Ids for CLDN11 Gene
Previous HGNC Symbols for CLDN11 Gene
Previous GeneCards Identifiers for CLDN11 Gene
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
GeneCards Summary for CLDN11 Gene
CLDN11 (Claudin 11) is a Protein Coding gene. Diseases associated with CLDN11 include Lyme Disease and Squamous Cell Papilloma. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN18.
UniProtKB/Swiss-Prot for CLDN11 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.