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CLDN11 Gene

protein-coding   GIFtS: 61
GCID: GC03P170136

Claudin 11

(Previous name: oligodendrocyte transmembrane protein)
(Previous symbol: OTM)
Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 111 2
OTM1 2 3 5
OSP2 3 5
Oligodendrocyte Transmembrane Protein1 2
Oligodendrocyte-Specific Protein2 3
claudin-112

External Ids:    HGNC: 85141   Entrez Gene: 50102   Ensembl: ENSG000000132977   OMIM: 6013265   UniProtKB: O755083   

Export aliases for CLDN11 gene to outside databases

Previous GC identifers: GC03P167279 GC03P171185 GC03P171538 GC03P171457 GC03P171619 GC03P167506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN11 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of
central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of
oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell
epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier
(BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants
encoding different isoforms have been identified.(provided by RefSeq, Aug 2010)

GeneCards Summary for CLDN11 Gene:
CLDN11 (claudin 11) is a protein-coding gene. Diseases associated with CLDN11 include horner's syndrome, and microcystic adenoma. GO annotations related to this gene include structural molecule activity and identical protein binding.

UniProtKB/Swiss-Prot: CLD11_HUMAN, O75508
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN11 gene promoter:
         USF1   GATA-3   AML1a   Evi-1   GATA-1   GATA-2   CREB   deltaCREB   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN11 promoter sequence
   Search Chromatin IP Primers for CLDN11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2-q26.3   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2-q26.3

CLDN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P170136:  view genomic region     (about GC identifiers)

Start:
170,136,653 bp from pter      End:
170,578,169 bp from pter
Size:
441,517 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLD11_HUMAN, O75508 (See protein sequence)
Recommended Name: Claudin-11  
Size: 207 amino acids; 21993 Da
Subunit: Interacts with tetraspanin-3/TSPAN3 (By similarity)
Secondary accessions: B2R7C1 D3DNQ5 Q5U0P3

Explore the universe of human proteins at neXtProt for CLDN11: NX_O75508

Explore proteomics data for CLDN11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171985.1  NP_005593.2  

    ENSEMBL proteins: 
     ENSP00000064724   ENSP00000417434   ENSP00000410185  
    Reactome Protein details: O75508

    CLDN11 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CLDN11
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    Novus Biologicals CLDN11 Proteins
    Novus Biologicals CLDN11 Lysate
    Sino Biological Recombinant Protein for CLDN11
    Sino Biological Cell Lysate for CLDN11
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLDN11

    CLDN11 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLDN11
    R&D Systems Antibodies for CLDN11 (Claudin-11)
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    Novus Biologicals CLDN11 Antibodies
    Abcam antibodies for CLDN11
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    LSBio Antibodies in human, mouse, rat for CLDN11

    CLDN11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CLDN11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLDN11
    Cloud-Clone Corp. CLIAs for CLDN11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR003555 Claudin11

    Graphical View of Domain Structure for InterPro Entry O75508

    ProtoNet protein and cluster: O75508

    2 Blocks protein domains:
    IPB003555 Claudin-11 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD11_HUMAN, O75508
    Similarity: Belongs to the claudin family


    CLDN11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD11_HUMAN, O75508
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--
         
    CLDN11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLDN11:
     Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cldn11):
     behavior/neurological  endocrine/exocrine gland  hearing/vestibular/ear  nervous system  reproductive system 
     vision/eye 

    CLDN11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cldn11tm1Sts for CLDN11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN11

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CLDN11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLDN11 (see all 58):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCLDN11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLDN11
    Predesigned siRNA for gene silencing in human, mouse, rat CLDN11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLDN11

    Clone
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    OriGene clones in human, mouse for CLDN11 (see all 9)
    OriGene ORF clones in mouse, rat for CLDN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN11 (NM_001185056)
    Sino Biological Human cDNA Clone for CLDN11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN11

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CLDN11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD11_HUMAN, O75508: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--

    CLDN11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN11 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN11
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN11
        Cell adhesion Tight junctions


    1 Reactome Pathway for CLDN11
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN11):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN11 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN11: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CLDN11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN11 (O755083 ENSP000000647244) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSPAN4O148173, ENSP000003243044I2D: score=4 STRING: ENSP00000324304
    TSPAN3O606373, ENSP000002679704I2D: score=2 STRING: ENSP00000267970
    CSF1P096033I2D: score=1 
    ITGB1P055563I2D: score=1 
    CLDN1ENSP000002955224STRING: ENSP00000295522
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007283spermatogenesis IEA--
    GO:0008366axon ensheathment IEA--
    GO:0016338calcium-independent cell-cell adhesion ISS--

    CLDN11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN11 (CLD11)

    1 HMDB Compound for CLDN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for CLDN11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',3'-cyclic nucleotide 72.6 2 12730962 (1), 15765008 (1)



    CLDN11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLDN11 gene (2 alternative transcripts): 
    NM_001185056.1  NM_005602.5  

    Unigene Cluster for CLDN11:

    Claudin 11
    Hs.31595  [show with all ESTs]
    Unigene Representative Sequence: AK098766
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000064724(uc003fgx.3) ENST00000486975(uc011bpt.1) ENST00000486429
    ENST00000489485(uc003fgy.3) ENST00000468358 ENST00000471373 ENST00000477531
    ENST00000488989 ENST00000480067(uc003fha.1) ENST00000451576

    miRNA
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    Block miRNA regulation of human, mouse, rat CLDN11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLDN11 (see all 58):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-25 hsa-let-7a-2* hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCLDN11 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN11
    Clone
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    OriGene ORF clones in mouse, rat for CLDN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN11 (NM_001185056)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN11
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN11
      QuantiTect SYBR Green Assays in human, mouse, rat CLDN11
      QuantiFast Probe-based Assays in human, mouse, rat CLDN11

    Additional mRNA sequence: 

    AF085871.1 AJ245901.1 AJ245902.1 AK098766.1 AK294087.1 AK294108.1 AK312923.1 BC013577.1 
    BT019402.1 BT019403.1 

    5 DOTS entries:

    DT.113286  DT.100774485  DT.91924737  DT.95073966  DT.40289488 

    Selected AceView cDNA sequences (see all 85):

    BM989755 NM_005602 BM989777 AL040912 AW665439 AJ245901 H18687 AL040911 
    H49448 CR595007 BP347739 AW316877 BX397382 D45304 BI599684 CK002146 
    BX460243 BC013577 N22392 AW264204 BQ687670 AJ245902 AI740681 BX327812 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTCCTGA
    CLDN11 Expression
    About this image


    CLDN11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Loop of Henle Cells Loop of Henle
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Oligodendrocyte-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Autopod Long Bone
             HyStem+BMP4-induced E15 cells
    CLDN11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.31595
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN11: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CLDN11
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN11
    QuantiTect SYBR Green Assays in human, mouse, rat CLDN11
    QuantiFast Probe-based Assays in human, mouse, rat CLDN11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN11 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn111 , 5 claudin 111, 5 86.63(n)1
    94.2(a)1
      3 (15.14 cM)5
    184171  NM_008770.31  NP_032796.11 
     311499465 
    chicken
    (Gallus gallus)
    Aves CLDN111 claudin 11 82.29(n)
    85.02(a)
      424990  XM_422797.4  XP_422797.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN116
    claudin 11
    82(a)
    1 ↔ 1
    3(7550342-7570209)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cldn111 claudin 11 70.05(n)
    68.12(a)
      100492817  XM_002931548.2  XP_002931594.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.124862 Transcribed sequence with weak similarity to protein more 75.2(n)    BI673109.1 


    ENSEMBL Gene Tree for CLDN11 (if available)
    TreeFam Gene Tree for CLDN11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN11 gene
    7 SIMAP similar genes for CLDN11 using alignment to 2 protein entries:     CLD11_HUMAN (see all proteins):
    CLDN19    CLDN7    CLDN18    CLDN1    CLDN10    CLDN3
    CLDN9

    CLDN11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN11 (see all 359)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792106321,2
    C,F--170134728(+) TTGCCG/ATTATG 1 -- us2k12Minor allele frequency- A:0.05NA EA 240
    rs2006873901,2
    --170134788(+) TATGA-/GGTAGGT 1 -- us2k10--------
    rs1146513811,2
    C,F--170134800(+) ACAGTT/CTTCAT 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1869475341,2
    --170134877(+) TGATGA/GAGCCA 1 -- us2k10--------
    rs1174400741,2
    F--170134952(+) CCCTTG/CTACTT 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs762191141,2
    F--170135076(+) GATTGC/TACTGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1886962691,2
    --170135237(+) AGGGAA/GTGGAT 1 -- us2k10--------
    rs730383721,2
    C--170135538(+) CCCTTG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1160169511,2
    F--170135581(+) AGTTCG/ATGAAA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1398583191,2
    C--170135685(+) GTAAT-/TTGTTG
            
    TTGTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN11 (170136653 - 170386653 bp, first 250kb of CLDN11)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLDN11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7356OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN11
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601326    OMIM disorders: --

    Selected diseases for CLDN11 (see all 23):    
    About MalaCards
    horner's syndrome    microcystic adenoma    lyme disease    cocaine abuse
    shigellosis    encephalomyelitis    choroiditis    multiple sclerosis
    endotheliitis    papilloma    crohn's disease    meningioma
    hepatitis c    meningitis    adenoma    infertility
    bipolar disorder    arthritis    hepatitis    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for CLDN11:
    Horner's syndrome

    CLDN11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    7 Novoseek inferred disease relationships for CLDN11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lyme disease 64.5 1 8740122 (1)
    borreliosis 56.4 2 7664493 (2)
    demyelination 45.8 1 18412169 (1)
    multiple sclerosis 42.3 3 11746369 (1), 18412169 (1), 20236710 (1)
    encephalomyelitis 26.2 1 10358205 (1)
    neurological disorders 23 1 7664493 (1)
    arthritis 3.39 2 7685738 (1)

    Genetic Association Database (GAD): CLDN11

    Export disorders for CLDN11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN11 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with CLDN11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. (PubMed id 10700007)1, 2, 9 Bronstein J.M.... Stevens D.B. (J. Neurosci. Res. 2000)
    2. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. (PubMed id 8661061)1, 3, 9 Bronstein J.M....Farber D.B. (Genomics 1996)
    3. Isolation and characterization of a novel oligodendrocyte-specific protein. (PubMed id 8797478)1, 3, 9 Bronstein J.M....Farber D.B. (Neurology 1996)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells. (PubMed id 19956721)1, 9 Agarwal R....Meltzer S.J. (PLoS ONE 2009)
    6. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. (PubMed id 19241088)1, 9 Fink C....Brehm R. (Histochem. Cell Biol. 2009)
    7. Developmental expression of OSP/claudin-11. (PubMed id 10797530)1, 9 Bronstein J.M....Kornblum H.I. (J. Neurosci. Res. 2000)
    8. Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve. (PubMed id 18412169)1, 9 Bajramovic J.J....Ben-Nun A. (Eur. J. Immunol. 2008)
    9. Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function. (PubMed id 19622796)1, 9 Wessells H....Chitaley K. (Physiol. Genomics 2009)
    10. Expression of complement messenger RNAs and proteins by human oligodendroglial cells. (PubMed id 12730962)1, 9 Hosokawa M....McGeer P.L. (Glia 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5010 HGNC: 8514 AceView: CLDN11 Ensembl:ENSG00000013297 euGenes: HUgn5010
    ECgene: CLDN11 Kegg: 5010 H-InvDB: CLDN11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLDN11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CLDN11 gene:
    Search GeneIP for patents involving CLDN11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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