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CLDN10 Gene

protein-coding   GIFtS: 59
GCID: GC13P096085

Claudin 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 101 2
OSP-Like Protein2 3
CPETRL32
OSP-L2
claudin-102

External Ids:    HGNC: 20331   Entrez Gene: 90712   Ensembl: ENSG000001348737   UniProtKB: P783693   

Export aliases for CLDN10 gene to outside databases

Previous GC identifers: GC13P094445 GC13P090473 GC13P094922 GC13P093783 GC13P094883 GC13P076683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN10 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. The expression level of this gene is associated with
recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different
isoforms have been reported, but the transcript sequences of some variants are not determined.(provided by
RefSeq, Jun 2010)

GeneCards Summary for CLDN10 Gene:
CLDN10 (claudin 10) is a protein-coding gene. Diseases associated with CLDN10 include biphasic synovial sarcoma, and synovial sarcoma. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is ENSG00000262302.

UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to
create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation
selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney

Gene Wiki entry for CLDN10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN10 gene promoter:
         STAT1   AML1a   STAT4   STAT1beta   STAT1alpha   CREB   deltaCREB   STAT2   STAT3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN10 promoter sequence
   Search Chromatin IP Primers for CLDN10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31-q34   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q31-q34

CLDN10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN10 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P096085:  view genomic region     (about GC identifiers)

Start:
96,085,853 bp from pter      End:
96,232,013 bp from pter
Size:
146,161 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369 (See protein sequence)
Recommended Name: Claudin-10  
Size: 228 amino acids; 24488 Da
Secondary accessions: Q6IBF9 Q96N78
Alternative splicing: 3 isoforms:  P78369-1   P78369-2   P78369-3   (Produced by alternative splicing of isoform 2)

Explore the universe of human proteins at neXtProt for CLDN10: NX_P78369

Explore proteomics data for CLDN10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001153572.1  NP_008915.1  NP_878268.1  

    ENSEMBL proteins: 
     ENSP00000366069   ENSP00000299339   ENSP00000366051  
    Reactome Protein details: P78369

    CLDN10 Human Recombinant Protein Products:

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    Novus Biologicals CLDN10 Protein
    Novus Biologicals CLDN10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLDN10

    CLDN10 Antibody Products:

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    Abcam antibodies for CLDN10 (Q96N78, Q6IBF9, P78369)
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    CLDN10 Assay Products:

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    Cloud-Clone Corp. ELISAs for CLDN10
    Cloud-Clone Corp. CLIAs for CLDN10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003554 Claudin10
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P78369

    ProtoNet protein and cluster: P78369

    2 Blocks protein domains:
    IPB003554 Claudin-10 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369
    Domain: The fourth transmembrane region (161-181) is necessary for integration into tight junctions (By
    similarity)
    Similarity: Belongs to the claudin family


    CLDN10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD10_HUMAN, P78369
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to
    create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation
    selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney

         Genatlas biochemistry entry for CLDN10:
    claudin 10,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,widely expressed

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--
         
    CLDN10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLDN10:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cldn10):
     behavior/neurological  homeostasis/metabolism  renal/urinary system 

    CLDN10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN10

    miRNA
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    Block miRNA regulation of human, mouse, rat CLDN10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLDN10 (see all 13):
    hsa-miR-3659 hsa-miR-569 hsa-miR-148b* hsa-miR-3607-3p hsa-miR-548b-3p hsa-miR-944 hsa-miR-410 hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLDN10
    Predesigned siRNA for gene silencing in human, mouse, rat CLDN10

    Gene Editing
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    OriGene clones in human, mouse for CLDN10 (see all 16)
    OriGene ORF clones in mouse, rat for CLDN10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN10 (NM_006984)
    Sino Biological Human cDNA Clone for CLDN10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN10

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CLDN10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD10_HUMAN, P78369: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--

    CLDN10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN10 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Tight junction
    Tight junction
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN10
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes


    1 Reactome Pathway for CLDN10
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN10):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN10: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLDN10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN10 (ENSP000002993394) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    CLDN15ENSP000003088704STRING: ENSP00000308870
    CLDN16ENSP000002647344STRING: ENSP00000264734
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0007155cell adhesion TAS10508613
    GO:0016338calcium-independent cell-cell adhesion ISS--

    CLDN10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN10 (CLD10)

    1 HMDB Compound for CLDN10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLDN10 gene (3 alternative transcripts): 
    NM_001160100.1  NM_006984.4  NM_182848.3  

    Unigene Cluster for CLDN10:

    Claudin 10
    Hs.534377  [show with all ESTs]
    Unigene Representative Sequence: NM_182848
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376873(uc001vmg.2 uc010tii.1 uc001vmh.2) ENST00000299339
    ENST00000376855
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLDN10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLDN10 (see all 13):
    hsa-miR-3659 hsa-miR-569 hsa-miR-148b* hsa-miR-3607-3p hsa-miR-548b-3p hsa-miR-944 hsa-miR-410 hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLDN10
    Predesigned siRNA for gene silencing in human, mouse, rat CLDN10
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN10 (NM_006984)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN10
    Primer
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    OriGene qPCR primer pairs and template standards for CLDN10
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN10
      QuantiTect SYBR Green Assays in human, mouse, rat CLDN10
      QuantiFast Probe-based Assays in human, mouse, rat CLDN10

    Additional mRNA sequence: 

    AF339794.1 AK055855.1 AK315737.1 BC010920.1 CR456845.1 U89916.1 

    7 DOTS entries:

    DT.212544  DT.75199458  DT.92421647  DT.311780  DT.40118535  DT.92421648  DT.95070448 

    Selected AceView cDNA sequences (see all 91):

    AL699037 BG429316 AI522187 AK055855 AI089846 BU686852 AI861881 NM_182848 
    AW960040 AA341006 BC010920 CB119421 AA394111 AF339794 CA335155 CA776387 
    AW160992 CA450135 NM_006984 CF529753 BE857427 BF940228 AA366287 AV728902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN10 expression in normal human tissues (normalized intensities)      CLDN10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAGAAGA
    CLDN10 Expression
    About this image


    CLDN10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    CLDN10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534377
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN10: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CLDN10
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN10
    QuantiTect SYBR Green Assays in human, mouse, rat CLDN10
    QuantiFast Probe-based Assays in human, mouse, rat CLDN10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN10 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn101 , 5 claudin 101, 5 88.3(n)1
    93.86(a)1
      14 (62.55 cM)5
    581871  NM_021386.41  NP_067361.21 
     1187879085 
    chicken
    (Gallus gallus)
    Aves CLDN101 claudin 10 79.94(n)
    81.42(a)
      418790  NM_001277767.1  NP_001264696.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN106
    claudin 10
    80(a)
    1 ↔ 1
    3(85287096-85308869)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004962321 claudin-10-like 69.15(n)
    71.49(a)
      100496232  XM_002939526.2  XP_002939572.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cldn10a1 claudin 10a 67.98(n)
    69.3(a)
      368619  NM_001007037.1  NP_001007038.1 


    ENSEMBL Gene Tree for CLDN10 (if available)
    TreeFam Gene Tree for CLDN10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN10 gene
    ENSG000002623022  CLDN182  CLDN252  CLDN152  CLDN242  CLDN222  
    18 SIMAP similar genes for CLDN10 using alignment to 2 protein entries:     CLD10_HUMAN (see all proteins):
    CLDN7    CLDN19    CLDN18    CLDN5    CLDN15    CLDN1
    CLDN14    CLDN4    CLDN2    CLDN20    CLDN3    CLDN9
    CLDN6    CLDN8    CLDN17    CLDN24    CLDN22    CLDN11

    CLDN10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN10 (see all 1803)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489360251,2
    --96083929(+) TACTCC/TGGAGG 2 -- us2k10--------
    rs1838960971,2
    --96084036(+) GTCTTA/GAAATA 2 -- us2k10--------
    rs1156454751,2
    F--96084097(+) AAAAAA/TAAATC 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1141103611,2
    F--96084217(+) AGGAAC/TAGTCA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1139552231,2
    F--96084239(+) GGAGCG/AGAGTA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1176818641,2
    C,F--96084269(+) ATGTGA/GATATT 2 -- us2k12Minor allele frequency- G:0.03NA EA 240
    rs1924895901,2
    --96084376(+) ATAACA/GTAGGT 2 -- us2k10--------
    rs1436474721,2
    C--96084435(+) AAATAC/TGTAAG 2 -- us2k10--------
    rs1833813631,2
    --96084578(+) TGTGGC/TGCAAT 2 -- us2k10--------
    rs1481777631,2
    --96084708(+) TAGAGA/CCAGTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN10 (96085853 - 96232013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CLDN10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747847CNV Deletion23290073
    nsv525760CNV Loss19592680
    nsv900933CNV Loss21882294
    nsv7246OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    17 diseases for CLDN10:    About MalaCards
    biphasic synovial sarcoma    synovial sarcoma    nephrocalcinosis    follicular thyroid carcinoma
    hepatocellular carcinoma    epididymitis    endotheliitis    sarcoma
    lung adenocarcinoma    bipolar disorder    hepatitis c    thyroiditis
    schizophrenia    ovarian cancer    adenocarcinoma    hepatitis
    hiv-1

    1 disease from the University of Copenhagen DISEASES database for CLDN10:
    Nephrocalcinosis

    CLDN10 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CLDN10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 30.6 18 18025272 (7), 17390062 (2), 15701840 (1)

    Genetic Association Database (GAD): CLDN10
    Human Genome Epidemiology (HuGE) Navigator: CLDN10 (3 documents)

    Export disorders for CLDN10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN10 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with CLDN10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. (PubMed id 18025272)1, 3, 9 Ip Y.C....Fan S.T. (Mol. Cancer Ther. 2007)
    2. Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. (PubMed id 19383724)1, 2, 9 GA1nzel D....MA1ller D. (J. Cell. Sci. 2009)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma. (PubMed id 15701840)1, 9 Cheung S.T....So S. (Clin. Cancer Res. 2005)
    7. Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b. (PubMed id 23760508)1 Li J....Yu A.S. (J. Biol. Chem. 2013)
    8. Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. (PubMed id 23284715)1 Kammula E.C....Willbold D. (PLoS ONE 2012)
    9. Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers. (PubMed id 22076167)1 Merikallio H....Soini Y. (Int J Clin Exp Pathol 2011)
    10. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9071 HGNC: 2033 AceView: CLDN10 Ensembl:ENSG00000134873 euGenes: HUgn9071
    ECgene: CLDN10 Kegg: 9071 H-InvDB: CLDN10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLDN10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLDN10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLDN10 gene:
    Search GeneIP for patents involving CLDN10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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