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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN10 Gene

protein-coding   GIFtS: 57
GCID: GC13P096085

claudin 10
 Explore 17 diseases affiliated with
CLDN10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLDN10    

Aliases
for CLDN10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Claudin 101 2
CPETRL31 2
OSP-L1 2
OSP-Like Protein2 3
Claudin-101

External Ids:    HGNC: 20331   Entrez Gene: 90712   Ensembl: ENSG000001348737   UniProtKB: P783693   

Export aliases for CLDN10 gene to outside databases

Previous GC identifers: GC13P094445 GC13P090473 GC13P094922 GC13P093783 GC13P094883 GC13P076683


Summaries
for CLDN10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN10:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely
through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in
maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of
primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been
reported, but the transcript sequences of some variants are not determined.(provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN10


Genomic Views
for CLDN10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN10 gene promoter:
         STAT1   AML1a   STAT4   STAT1beta   STAT1alpha   CREB   deltaCREB   STAT2   STAT3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN10 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31-q34   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q31-q34

CLDN10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN10 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P096085:  view genomic region     (about GC identifiers)

Start:
 96,085,853 bp from pter      End:
 96,232,010 bp from pter
Size:
 146,158 bases      Orientation:
 plus strand

Proteins
for CLDN10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369 (See protein sequence)
Recommended Name: Claudin-10  
Size: 228 amino acids; 24488 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Secondary accessions: Q96N78
Alternative splicing: 2 isoforms:  P78369-1   P78369-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLDN10: NX_P78369

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78369

    • CLDN10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001153572.1  NP_008915.1  NP_878268.1  

    ENSEMBL proteins: 
     ENSP00000366069   ENSP00000299339   ENSP00000366051  
    Reactome Protein details: P78369
    Human Recombinant Protein Products: 
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    Novus Biologicals CLDN10 Protein
    Novus Biologicals CLDN10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN10

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--


    CLDN10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLDN10

    Protein Domains /
    Families
    for CLDN10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR003554 Claudin10
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P78369

    ProtoNet protein and cluster: P78369

    2 Blocks protein families:
    IPB003554 Claudin-10 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369
    Similarity: Belongs to the claudin family


    Function
    for CLDN10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Genatlas biochemistry entry for CLDN10:
    claudin 10,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural
    components of tight junction (TJ) strands,widely expressed

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN10 (see all 13):
    hsa-miR-3659 hsa-miR-569 hsa-miR-148b* hsa-miR-3607-3p hsa-miR-548b-3p hsa-miR-944 hsa-miR-410 hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN10 (see all 7)
    OriGene shRNA RFP: CLDN10
    OriGene siRNA: CLDN10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLDN10

    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN10 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLDN10

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--


    CLDN10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLDN10:
     Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cldn10):
     behavior/neurological  homeostasis/metabolism  renal/urinary system 

    CLDN10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    3Hepatitis C
    		Hepatitis C1.00
    4Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00
    5Tight junction
    		Tight junction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN10
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    4        Reactome Pathways for CLDN10
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN10):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLDN10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/25 Interacting proteins for CLDN10 (ENSP000002993394) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    CLDN15ENSP000003088704STRING: ENSP00000308870
    CLDN16ENSP000002647344STRING: ENSP00000264734
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10508613
    GO:0016338calcium-independent cell-cell adhesion ISS--


    CLDN10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN10

    1 HMDB Compound for CLDN10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CLDN10 / CLD10 

    Transcripts
    for CLDN10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN10 gene (3 alternative transcripts): 
    NM_001160100.1  NM_006984.4  NM_182848.3  

    Unigene Cluster for CLDN10:

    Claudin 10
    Hs.534377  [show with all ESTs]
    Unigene Representative Sequence: NM_182848
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376873(uc001vmg.2 uc010tii.1 uc001vmh.2) ENST00000299339
    ENST00000376855

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN10 (see all 13):
    hsa-miR-3659 hsa-miR-569 hsa-miR-148b* hsa-miR-3607-3p hsa-miR-548b-3p hsa-miR-944 hsa-miR-410 hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN10 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN10 (see all 7)
    OriGene shRNA RFP: CLDN10
    OriGene siRNA: CLDN10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN10 (see all 10)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN10

    Additional cDNA sequence: 

    AF339794.1 AK055855.1 AK315737.1 BC010920.1 CR456845.1 U89916.1 

    7 DOTS entries:

    DT.212544  DT.75199458  DT.92421647  DT.311780  DT.40118535  DT.92421648  DT.95070448 

    24/91 AceView cDNA sequences (see all 91):

    AI861881 CA450135 AW960040 CA335155 AF339794 AA394111 BC010920 AI089846 
    CA776387 AI522187 AL699037 AK055855 AA341006 NM_182848 BG429316 AW160992 
    NM_006984 CB119421 BU686852 CB047643 BG697724 BG701489 CA776623 BG707414 

    GeneLoc Exon Structure


    Expression
    for CLDN10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGAGAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyLoop of HenleLoop of Henle CellsKidney
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See CLDN10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN10

    SOURCE GeneReport for Unigene cluster: Hs.534377
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN10: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN10

    Orthologs
    for CLDN10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN10 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLDN101 claudin 10 79.79(n)
    81.42(a)    		   418790  XM_001232226.2  XP_001232227.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CLDN106
    		 --
    		 79(a)
    		 1 ↔ 1
    		 3(85287309-85308869)
    zebrafish
    (Danio rerio)    		 Actinopterygii cldn101 claudin 10 68.73(n)
    69.91(a)    		   368619  NM_001007037.1  NP_001007038.1 


    ENSEMBL Gene Tree for CLDN10 (if available)
    TreeFam Gene Tree for CLDN10 (if available) 

    Paralogs
    for CLDN10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN10 gene
    CLDN92  CLDN42  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN152  
    CLDN32  CLDN12  CLDN142  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN10 using alignment to 3 protein entries:     CLD10_HUMAN (see all proteins):
    CLDN7    CLDN19    CLDN5    CLDN18    CLDN1    CLDN14
    CLDN4    CLDN15    CLDN2    CLDN20    CLDN3    CLDN9
    CLDN8    CLDN17    CLDN6    CLDN24    CLDN22    CLDN11

    CLDN10 for paralogs           About GeneDecksing



    Genomic Variants
    for CLDN10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2762 NCBI SNPs in CLDN10 are shown (see all 2762)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1489360251,2
    		--96083929(+) TACTCC/TGGAGG 2 -- us2k10--------
    rs1838960971,2
    		--96084036(+) GTCTTA/GAAATA 2 -- us2k10--------
    rs1156454751,2
    		F,--96084097(+) AAAAAA/TAAATC 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1141103611,2
    		--96084217(+) AGGAAC/TAGTCA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1139552231,2
    		--96084239(+) GGAGCG/AGAGTA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1176818641,2
    		C,F,--96084269(+) ATGTGA/GATATT 2 -- us2k12Minor allele frequency- G:0.03NA EA 240
    rs1924895901,2
    		--96084376(+) ATAACA/GTAGGT 2 -- us2k10--------
    rs1436474721,2
    		--96084435(+) AAATAC/TGTAAG 2 -- us2k10--------
    rs1833813631,2
    		--96084578(+) TGTGGC/TGCAAT 2 -- us2k10--------
    rs1481777631,2
    		--96084708(+) TAGAGA/CCAGTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN10 (96085853 - 96232010 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLDN10: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN10
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN10

    Disorders / Diseases
    for CLDN10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN10 for disorders           About GeneDecksing

    17 diseases for CLDN10:    About MalaCards
    hepatocellular carcinoma    biphasic synovial sarcoma    carcinoma    biliary tract cancer
    follicular thyroid carcinoma    synovial sarcoma    epithelial ovarian cancer    nephrocalcinosis
    bipolar disorder    thyroid carcinoma    hepatitis c    ovarian cancer
    epididymitis    thyroiditis    hepatitis    sarcoma
    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for CLDN10:
    Nephrocalcinosis

    1 Novoseek disease relationship for CLDN10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 30.6 18 18025272 (7), 17390062 (2), 15701840 (1)

    Human Genome Epidemiology (HuGE) Navigator: CLDN10 (3 documents)

    Export disorders for CLDN10 gene to outside databases

    Publications
    for CLDN10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN10 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CLDN10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. (PubMed id 18025272)1, 3, 9 Ip Y.C....Fan S.T. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma. (PubMed id 15701840)1, 9 Cheung S.T....So S. (2005)
    5. Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. (PubMed id 19383724)1, 9 GA1nzel D....MA1ller D. (2009)
    6. Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers. (PubMed id 22076167)1 Merikallio H....Soini Y. (2011)
    7. Expression of claudin 10 protein in hepatocellular ca rcinoma: impact on survival. (PubMed id 21647678)1 Huang G.W....Zeng L. (2011)
    8. Claudins in human cancer: a review. (PubMed id 19924644)1 Ouban A. and Ahmed A.A. (2010)
    9. Claudin 10 is a glandular epithelial marker in the ch icken model as human epithelial ovarian cancer. (PubMed id 21370593)1 Seo H.W....Han J.Y. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for CLDN10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CLDN10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9071 HGNC: 2033 AceView: CLDN10 Ensembl:ENSG00000134873 euGenes: HUgn9071
    ECgene: CLDN10 Kegg: 9071 H-InvDB: CLDN10

    Other Databases showing CLDN10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLDN10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLDN10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN10 gene:
    Search GeneIP for patents involving CLDN10

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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