Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLDN10 Gene

Aliases for CLDN10 Gene

  • Claudin 10 2 3 5
  • OSP-Like Protein 3 4
  • CPETRL3 3
  • OSP-L 3

External Ids for CLDN10 Gene

Previous GeneCards Identifiers for CLDN10 Gene

  • GC13P094445
  • GC13P090473
  • GC13P094922
  • GC13P093783
  • GC13P094883
  • GC13P096085
  • GC13P076683

Summaries for CLDN10 Gene

Entrez Gene Summary for CLDN10 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN10 Gene

CLDN10 (Claudin 10) is a Protein Coding gene. Diseases associated with CLDN10 include hepatocellular carcinoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN18.

UniProtKB/Swiss-Prot for CLDN10 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henles loop in kidney.

Gene Wiki entry for CLDN10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN10 Gene

Genomics for CLDN10 Gene

Regulatory Elements for CLDN10 Gene

Genomic Location for CLDN10 Gene

Chromosome:
13
Start:
95,433,599 bp from pter
End:
95,579,759 bp from pter
Size:
146,161 bases
Orientation:
Plus strand

Genomic View for CLDN10 Gene

Genes around CLDN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN10 Gene

Proteins for CLDN10 Gene

  • Protein details for CLDN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78369-CLD10_HUMAN
    Recommended name:
    Claudin-10
    Protein Accession:
    P78369
    Secondary Accessions:
    • Q6IBF9
    • Q96N78

    Protein attributes for CLDN10 Gene

    Size:
    228 amino acids
    Molecular mass:
    24488 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLDN10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLDN10 Gene

Proteomics data for CLDN10 Gene at MOPED

Post-translational modifications for CLDN10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN10 Gene

Antibody Products

No data available for DME Specific Peptides for CLDN10 Gene

Domains & Families for CLDN10 Gene

Gene Families for CLDN10 Gene

Protein Domains for CLDN10 Gene

Graphical View of Domain Structure for InterPro Entry

P78369

UniProtKB/Swiss-Prot:

CLD10_HUMAN :
  • The fourth transmembrane region (161-181) is necessary for integration into tight junctions.
  • Belongs to the claudin family.
Domain:
  • The fourth transmembrane region (161-181) is necessary for integration into tight junctions.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN10: view

Function for CLDN10 Gene

Molecular function for CLDN10 Gene

GENATLAS Biochemistry:
claudin 10,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,widely expressed
UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henles loop in kidney.
genes like me logo Genes that share phenotypes with CLDN10: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDN10 Gene

Localization for CLDN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN10 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN10 Gene COMPARTMENTS Subcellular localization image for CLDN10 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CLDN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN10: view

Pathways & Interactions for CLDN10 Gene

genes like me logo Genes that share pathways with CLDN10: view

Interacting Proteins for CLDN10 Gene

Gene Ontology (GO) - Biological Process for CLDN10 Gene

None

No data available for SIGNOR curated interactions for CLDN10 Gene

Drugs & Compounds for CLDN10 Gene

(1) Drugs for CLDN10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLDN10: view

Transcripts for CLDN10 Gene

Unigene Clusters for CLDN10 Gene

Claudin 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN10 Gene

No ASD Table

Relevant External Links for CLDN10 Gene

GeneLoc Exon Structure for
CLDN10
ECgene alternative splicing isoforms for
CLDN10

Expression for CLDN10 Gene

mRNA expression in normal human tissues for CLDN10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN10 Gene

This gene is overexpressed in Pancreas (x12.7), Brain - Amygdala (x4.9), and Kidney - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for CLDN10 Gene

This gene is overexpressed in Plasma (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLDN10 Gene



SOURCE GeneReport for Unigene cluster for CLDN10 Gene Hs.534377

genes like me logo Genes that share expression patterns with CLDN10: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CLDN10 Gene

Orthologs for CLDN10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDN10 35
  • 92.54 (n)
  • 96.93 (a)
CLDN10 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN10 35
  • 93.86 (n)
  • 96.93 (a)
CLDN10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn10 35
  • 88.3 (n)
  • 93.86 (a)
Cldn10 16
Cldn10 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDN10 35
  • 99.42 (n)
  • 100 (a)
CLDN10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn10 35
  • 88.6 (n)
  • 95.61 (a)
oppossum
(Monodelphis domestica)
Mammalia CLDN10 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN10 35
  • 79.94 (n)
  • 81.42 (a)
CLDN10 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN10 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496232 35
  • 69.15 (n)
  • 71.49 (a)
zebrafish
(Danio rerio)
Actinopterygii cldn10a 35
  • 67.98 (n)
  • 69.3 (a)
CLDN10 (3 of 5) 36
  • 31 (a)
OneToMany
CLDN10 (4 of 5) 36
  • 37 (a)
OneToMany
cldn10a 36
  • 67 (a)
OneToMany
cldn10b 36
  • 63 (a)
OneToMany
cldn10l2 36
  • 26 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4877 35
Species with no ortholog for CLDN10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN10 Gene

ENSEMBL:
Gene Tree for CLDN10 (if available)
TreeFam:
Gene Tree for CLDN10 (if available)

Paralogs for CLDN10 Gene

Paralogs for CLDN10 Gene

(18) SIMAP similar genes for CLDN10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN10: view

Variants for CLDN10 Gene

Sequence variations from dbSNP and Humsavar for CLDN10 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000600 -- 95,568,849(-) TCTCC(C/G)TGTTC intron-variant
rs1000601 -- 95,568,561(-) ACCCC(A/G)CCCAA intron-variant
rs869529 -- 95,477,689(-) ATCCA(C/G)AGTAG intron-variant
rs869530 -- 95,477,683(-) AGTAG(A/G)GTTGG intron-variant
rs869531 -- 95,477,463(-) CCGGG(G/T)GATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN10 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv900933 CNV Loss 21882294
esv2747847 CNV Deletion 23290073
nsv525760 CNV Loss 19592680

Variation tolerance for CLDN10 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN10 Gene

HapMap Linkage Disequilibrium report
CLDN10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN10 Gene

Disorders for CLDN10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLDN10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLDN10

Genetic Association Database (GAD)
CLDN10
Human Genome Epidemiology (HuGE) Navigator
CLDN10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN10
genes like me logo Genes that share disorders with CLDN10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN10 Gene

Publications for CLDN10 Gene

  1. Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. (PMID: 18025272) Ip Y.C. … Fan S.T. (Mol. Cancer Ther. 2007) 2 3 23 67
  2. Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. (PMID: 19383724) GA1nzel D. … MA1ller D. (J. Cell. Sci. 2009) 3 23
  3. Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma. (PMID: 15701840) Cheung S.T. … So S. (Clin. Cancer Res. 2005) 3 23
  4. High diagnostic accuracy based on CLDN10, HMGA2 and LAMB3 transcripts in papillary thyroid carcinoma. (PMID: 25867809) Camargo Barros-Filho M. … Paulo Kowalski L. (J. Clin. Endocrinol. Metab. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CLDN10 Gene

Sources for CLDN10 Gene

Back to Top

Content