Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN1 Gene

protein-coding   GIFtS: 66
GCID: GC03M190023

claudin 1
 Explore 52 diseases affiliated with
CLDN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLDN1    

Aliases
for CLDN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Claudin 11 2     Claudin-11
SEMP11 2 3 5     Senescence-Associated Epithelial Membrane Protein 12
ILVASC1 2 5     Senescence-Associated Epithelial Membrane Protein3
CLD12 3     

External Ids:    HGNC: 20321   Entrez Gene: 90762   Ensembl: ENSG000001633477   OMIM: 6037185   UniProtKB: O958323   

Export aliases for CLDN1 gene to outside databases

Previous GC identifers: GC03M187025 GC03M191284 GC03M191425 GC03M191344 GC03M191506 GC03M187423


Summaries
for CLDN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN1:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. These junctions are comprised of sets of continuous networking strands in the
outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The
protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight
junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLD1_HUMAN, O95832
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells

Gene Wiki entry for CLDN1


Genomic Views
for CLDN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN1 gene promoter:
         HFH-3   AML1a   Bach2   RelA   NF-kappaB   FOXI1   MEF-2A   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLDN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28-q29   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q28-q29

CLDN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M190023:  view genomic region     (about GC identifiers)

Start:
 190,023,490 bp from pter      End:
 190,040,264 bp from pter
Size:
 16,775 bases      Orientation:
 minus strand

Proteins
for CLDN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD1_HUMAN, O95832 (See protein sequence)
Recommended Name: Claudin-1  
Size: 211 amino acids; 22744 Da
Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2,
homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By
similarity). May interact with HCV E1 and E2 proteins
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By
similarity)

Explore the universe of human proteins at neXtProt for CLDN1: NX_O95832

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95832

    • CLDN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066924.1  
    ENSEMBL proteins: 
     ENSP00000295522  
    Reactome Protein details: O95832
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CLDN1
    OriGene Protein Over-expression Lysate: CLDN1
    OriGene Custom Protein Services for CLDN1 
    GenScript Custom Purified and Recombinant Proteins Services for CLDN1
    Novus Biologicals CLDN1 Proteins
    Novus Biologicals CLDN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS9647647
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane TAS9931503
    GO:0016324apical plasma membrane IEA--


    CLDN1 for ontologies           About GeneDecksing



    CLDN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLDN1
    R&D Systems Antibodies for CLDN1 (Claudin-1)
    Cell Signaling Technology (CST) Antibodies for CLDN1  (claudin 1)
    OriGene Antibodies: CLDN1
    OriGene Custom Antibody Services for CLDN1 
    GenScript Custom Superior Antibodies Services for CLDN1
    Novus Biologicals CLDN1 Antibodies
    Abcam antibodies for CLDN1 
    Uscn Antibodies for CLDN1
    ThermoFisher Antibodies for CLDN1

    Assay Products for CLDN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLDN1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CLDN1

    Protein Domains /
    Families
    for CLDN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR003548 Claudin1
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O95832

    ProtoNet protein and cluster: O95832

    2 Blocks protein families:
    IPB003548 Claudin-1 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD1_HUMAN, O95832
    Similarity: Belongs to the claudin family


    Function
    for CLDN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD1_HUMAN, O95832
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells

         Genatlas biochemistry entry for CLDN1:
    claudin 1,clostridium perfringens enterotoxin receptor 1,claudin family of major structural components of tight
    junction (TJ) strands,expressed in thyroid,placenta,pancreas,lung and kidney

    miRNA
    Products:            		miRTarBase miRNAs that target CLDN1:
    hsa-mir-155 (MIRT001558)

    OriGene 3'-UTR Clone: CLDN1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN1 (see all 23):
    hsa-miR-562 hsa-miR-300 hsa-miR-3942-5p hsa-miR-29c hsa-miR-29a hsa-miR-583 hsa-miR-155 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN1 (see all 7)
    OriGene shRNA RFP: CLDN1
    OriGene siRNA: CLDN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLDN1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN1 (NM_001185056)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CLDN1
    LifeMap BioReagents: cell line associated with CLDN1: PureStem ES-209, Meso-prx/latp Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--


    CLDN1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLDN1:
     Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-outs for CLDN1: Cldn1tm1Lex Cldn1tm1Sts
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cldn1):
     growth/size  homeostasis/metabolism  integument  mortality/aging 

    CLDN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    3Cell adhesion Endothelial cell contacts by junctional mechanisms
    		Cell adhesion Endothelial cell contacts by junctional mechanisms1.00
    		Cell adhesion_Endothelial cell contacts by junctional mechanisms0.97
    4Pathogenic Escherichia coli infection
    		Pathogenic Escherichia coli infection1.00
    		Pathogenic Escherichia coli infection0.98
    5Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CLDN1
        Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN1
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes
    WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for CLDN1
        Adhesion

    2 GeneGo (Thomson Reuters) Pathways for CLDN1
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    2 BioSystems Pathways for CLDN1 
        Pathogenic Escherichia coli infection
    Nectin adhesion pathway

    4        Reactome Pathways for CLDN1
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    5         Kegg Pathways  (Kegg details for CLDN1):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Pathogenic Escherichia coli infection
    Hepatitis C


    CLDN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLDN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for CLDN1 (O958322, 3 ENSP000002955224) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD4O608852, 3, ENSP000002633774MINT-63186 I2D: score=4 STRING: ENSP00000263377
    INADLQ8NI352, 3, ENSP000003602004MINT-58719 I2D: score=2 STRING: ENSP00000360200
    TJP1Q071573, ENSP000002815374I2D: score=5 STRING: ENSP00000281537
    CLDN5O005013, ENSP000003845544I2D: score=1 STRING: ENSP00000384554
    MMP14P502813, ENSP000003082084I2D: score=1 STRING: ENSP00000308208
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9647647
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----
    GO:0045216cell-cell junction organization IMP--


    CLDN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN1

    1 HMDB Compound for CLDN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CLDN1 / CLD1 

    Transcripts
    for CLDN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN1 gene: 
    NM_021101.4  

    Unigene Cluster for CLDN1:

    Claudin 1
    Hs.439060  [show with all ESTs]
    Unigene Representative Sequence: NM_021101
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295522(uc003fsh.3) ENST00000490800

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CLDN1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN1 (see all 23):
    hsa-miR-562 hsa-miR-300 hsa-miR-3942-5p hsa-miR-29c hsa-miR-29a hsa-miR-583 hsa-miR-155 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN1 (see all 7)
    OriGene shRNA RFP: CLDN1
    OriGene siRNA: CLDN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN1 (NM_001185056)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN1

    Additional cDNA sequence: 

    AF086514.1 AF101051.1 AF114837.1 AF115546.1 AF134160.1 AK225963.1 AK296934.1 AK312866.1 
    AY358652.1 BC012471.1 CR457138.1 EF564137.1 

    9 DOTS entries:

    DT.453813  DT.95117111  DT.100643553  DT.97825926  DT.120925754  DT.100754287  DT.75161381  DT.95238946 
    DT.449027 

    24/243 AceView cDNA sequences (see all 243):

    AW631445 BG289942 BQ641744 AI300819 BG286357 CK819775 BU153383 H95362 
    T11196 BQ923351 BM982831 CD519342 AI433150 AU108063 BM127057 CD676887 
    BX507101 NM_021101 AI858215 BC012471 BM141921 AA921786 CK819774 BM141663 

    GeneLoc Exon Structure


    Expression
    for CLDN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGATATCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyBowman's CapsuleParietal Epithelial CellsKidney
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    TestisSeminiferous TubulesSertoli cellsTestis
    BrainChoroid PlexusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    N2/LSB induced-cells (Generation of midbra...)
    Definitive endoderm-like cells (Generation of mesend...)

    See CLDN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN1

    SOURCE GeneReport for Unigene cluster: Hs.439060

    UniProtKB/Swiss-Prot: CLD1_HUMAN, O95832
    Tissue specificity: Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN1: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN1

    Orthologs
    for CLDN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLDN11 claudin 1 72.99(n)
    74.41(a)    		   424910  NM_001013611.2  NP_001013629.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLDN16
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343386.1(311094-315345)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ064054.12   -- 70.13(n)    BJ064054.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF260240.12   -- 71.76(n)   60635  AF260240.1 


    ENSEMBL Gene Tree for CLDN1 (if available)
    TreeFam Gene Tree for CLDN1 (if available) 

    Paralogs
    for CLDN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN1 gene
    CLDN92  CLDN42  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN102  
    CLDN152  CLDN32  CLDN142  CLDN62  CLDN72  CLDN192  
    18/19 SIMAP similar genes for CLDN1 using alignment to 2 protein entries:     CLD1_HUMAN (see all proteins) (see all similar genes):
    CLDN7    CLDN19    CLDN4    CLDN3    CLDN9    CLDN6
    CLDN8    CLDN5    CLDN17    CLDN14    CLDN2    CLDN20
    CLDN18    CLDN10    CLDN24    CLDN15    CLDN22    CLDN25

    CLDN1 for paralogs           About GeneDecksing



    Genomic Variants
    for CLDN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/395 NCBI SNPs in CLDN1 are shown (see all 395)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1159424181,2
    		C,F,--187424276(+) AAATGG/AAACAG 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1120030341,2
    		C,--187424314(+) AGAATG/AGAAAT 1 -- ut312Minor allele frequency- A:0.03CSA WA 120
    rs730564921,2
    		C,--187424364(+) TATGTG/ACGTAG 1 -- ut312Minor allele frequency- A:0.26WA 120
    rs801879251,2
    		C,F,--187424921(+) ACAACA/CCCTGG 1 -- ut311Minor allele frequency- C:0.07WA 118
    rs730564951,2
    		C,--187425212(+) AAAATA/CAAATA 1 -- ut312Minor allele frequency- C:0.03WA 120
    rs559454571,2
    		C,--187425296(+) AGGCAC/TCCAAA 1 -- ut312Minor allele frequency- T:0.05WA 120
    rs98250881,2
    		C,F,A,H,--187425332(+) TTGACT/CGTTAC 1 -- ut3118Minor allele frequency- C:0.10EA NS NA WA 1868
    rs557249721,2
    		C,F,--187425409(+) ATTTAC/ACTATT 1 -- ut311Minor allele frequency- A:0.12NA 120
    rs730564961,2
    		C,--187426038(+) AAAATG/CAATAC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs98477921,2
    		C,F,H,--187426228(+) CATATA/GTAGGA 1 -- int14Minor allele frequency- G:0.11EA NS WA 418

    HapMap Linkage Disequilibrium report for CLDN1 (190023490 - 190040264 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLDN1: --
    Human Gene Mutation Database (HGMD): CLDN1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN1
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN1

    Disorders / Diseases
    for CLDN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN1 for disorders           About GeneDecksing

    OMIM gene information: 603718   
    OMIM disorders: 607626  
    UniProtKB/Swiss-Prot: CLD1_HUMAN, O95832
  • Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626];
    • also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare autosomal
    recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, vulgar type ichthyosis,
    and sclerosing cholangitis

    20/52 diseases for CLDN1 (see all 52):    About MalaCards
    sclerosing cholangitis    ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis    neonatal ichthyosis-sclerosing cholangitis syndrome    cholangitis
    ichthyosis    dendritic cell sarcoma    follicular dendritic cell sarcoma    squamous cell carcinoma
    venous insufficiency    oral squamous cell carcinoma    alopecia    esophageal squamous cell carcinoma
    neurilemmoma    inflammatory bowel disease    lung squamous cell carcinoma    perineurioma
    atopic dermatitis    sporadic breast cancer    herpes simplex    hypotrichosis

    1 disease from the University of Copenhagen DISEASES database for CLDN1:
    Perineurioma

    5 Novoseek disease relationships for CLDN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 22.6 23 11071387 (5), 14648703 (3), 11920682 (3), 15743508 (1) (see all 6)
    breast carcinoma 18.2 1 11071387 (1)
    tumors 11.5 25 11920682 (5), 14648703 (3), 11071387 (2), 18991282 (1) (see all 7)
    carcinoma 2.57 4 18991282 (2), 14648703 (1)
    metastasis 0 12 18787218 (4), 15743508 (1), 17611630 (1)

    Human Genome Epidemiology (HuGE) Navigator: CLDN1 (2 documents)

    Export disorders for CLDN1 gene to outside databases

    Publications
    for CLDN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN1 gene, integrated from 9 sources (see all 131):
    (articles sorted by number of sources associating them with CLDN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids. (PubMed id 10828592)1, 2, 3, 9 Halford S....Adamson P. (2000)
    2. Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. (PubMed id 11071387)1, 2, 9 Kraemer F.... Weber B.H.F. (2000)
    3. SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily. (PubMed id 9931503)1, 2, 9 Swisshelm K.L....Hosier S. (1999)
    4. Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. (PubMed id 17325668)1, 2, 9 Evans M.J.... Rice C.M. (2007)
    5. Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. (PubMed id 15521008)1, 2 Hadj-Rabia S.... Smahi A. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    9. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. (PubMed id 9647647)1, 2 Furuse M.... Tsukita S. (1998)
    10. Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus. (PubMed id 18211898)1, 9 Yang W....Wang T. (2008)

    External Searches for CLDN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLDN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9076 HGNC: 2032 AceView: CLDN1 Ensembl:ENSG00000163347 euGenes: HUgn9076
    ECgene: CLDN1 Kegg: 9076 H-InvDB: CLDN1

    Other Databases showing CLDN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLDN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLDN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN1 gene:
    Search GeneIP for patents involving CLDN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CLDN1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CLDN1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CLDN1 (Claudin-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CLDN1   OriGene shRNA RFP for CLDN1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN1  
     OriGene Protein Over-expression Lysate for CLDN1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CLDN1   OriGene 3'-UTR Clone for CLDN1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CLDN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLDN1   OriGene Custom Protein Services for CLDN1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN1
     GenScript Custom Purified and Recombinant Proteins Services for CLDN1 GenScript cDNA clones with any tag delivered in your preferred vector for CLDN1
     GenScript Custom Assay Services for CLDN1 GenScript Custom Superior Antibodies Services for CLDN1
     GenScript Custom overexpressing Cell Line Services for CLDN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CLDN1 
    (claudin 1)

     Regulatory tfbs in CLDN1 promoter
     Search Chromatin IP Primers for CLDN1
     RT2 qPCR Primer Assay in human, mouse, rat CLDN1
     GNC Network for CLDN1
     SABiosciences PCR Arrays including human, mouse, rat CLDN1
     Search Tocris compounds for CLDN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLDN1 antibodies
     CLDN1 proteins
     CLDN1 lysates
     Antibodies for CLDN1
     See all of Abcam's Antibodies, Kits and Proteins for CLDN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CLDN1 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Line associated with CLDN1: PureStem ES-209, Meso-prx/latp Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN1
     SwitchGear 3'UTR luciferase reporter plasmids for CLDN1
     SwitchGear Promoter luciferase reporter plasmids for CLDN1
     ThermoFisher Antibodies for CLDN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CLDN1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4