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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLCN6 Gene

protein-coding   GIFtS: 56
GCID: GC01P011866

chloride channel, voltage-sensitive 6

(Previous name: chloride channel 6 )
 Explore 5 diseases affiliated with
CLCN6 via our new
 Human Malady Compendium 
Biological research products
for CLCN6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chloride Channel, Voltage-Sensitive 61 2     Chloride Channel 61
CLC-61 2     Chloride Transport Protein 62
ClC-61 3     Chloride Channel Protein 63
KIAA00461 3     

External Ids:    HGNC: 20241   Entrez Gene: 11852   Ensembl: ENSG000000110217   OMIM: 6027265   UniProtKB: P517973   

Export aliases for CLCN6 gene to outside databases

Previous GC identifers: GC01P011939 GC01P011711 GC01P011475 GC01P011575 GC01P011800 GC01P011021


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLCN6:
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can
function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and
functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants.
Additional alternately spliced variants have been described but their full-length structure is unknown. (provided by
RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: CLCN6_HUMAN, P51797
Function: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the
conserved gating glutamate residues suggests that is functions as antiporter

Gene Wiki entry for CLCN6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLCN6 gene promoter:
         p53   AML1a   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLCN6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLCN6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLCN6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36

CLCN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLCN6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P011866:  view genomic region     (about GC identifiers)

Start:
11,866,207 bp from pter      End:
11,903,201 bp from pter
Size:
36,995 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLCN6_HUMAN, P51797 (See protein sequence)
Recommended Name: Chloride transport protein 6  
Size: 869 amino acids; 97289 Da
Subcellular location: Endosome membrane; Multi-pass membrane protein. Note=Detected in detergent-resistant lipid rafts
Miscellaneous: The CLC channel family contains both chloride channels and proton-coupled anion transporters that
exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for
family members that function as antiporters (By similarity)
Secondary accessions: A8K1T4 O60818 O60819 O60820 O60821 P78520 P78521 Q17R81 Q5SNW2 Q5SNW3 Q5SNX1
Q5SNX2 Q5SNX3 Q99427 Q99428 Q99429
Alternative splicing: 5 isoforms:  P51797-1   P51797-2   P51797-3   P51797-4   P51797-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLCN6: NX_P51797

Post-translational modifications:

  • N-glycosylated on several asparagine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51797

  • CLCN6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243888.1  NP_001277.1  

    ENSEMBL proteins: 
     ENSP00000234488   ENSP00000365680   ENSP00000365679   ENSP00000365670   ENSP00000308367  
    Reactome Protein details: P51797
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    Uscn Proteins for CLCN6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010008endosome membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS8543009


    CLCN6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLCN6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR014743 Cl-channel_core
     IPR000644 Cysta_beta_synth_core
     IPR002248 Cl_channel-6
     IPR001807 Cl-channel_volt-gated

    Graphical View of Domain Structure for InterPro Entry P51797

    ProtoNet protein and cluster: P51797

    3 Blocks protein families:
    IPB000644 CBS domain
    IPB001807 Chloride channel signature
    IPB002248 CLC-6 chloride channel signature


    UniProtKB/Swiss-Prot: CLCN6_HUMAN, P51797
    Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily
    Similarity: Contains 2 CBS domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CLCN6_HUMAN, P51797
    Function: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the
    conserved gating glutamate residues suggests that is functions as antiporter

         Genatlas biochemistry entry for CLCN6:
    chloride voltage-gated channel 6,97kDa,widely expressed

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity NAS8543009
    GO:0005524ATP binding IEA--
    GO:0015297antiporter activity IEA--


    CLCN6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLCN6:
     Increased circadian rhythm amp 

    Animal Models:
         Mouse knock-out Clcn6tm1Tjj for CLCN6
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clcn6):
     behavior/neurological  cellular  integument  nervous system 

    CLCN6 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA1.00
    PKA Signaling0.56
    cAMP Pathway0.77
    2Ion channel transport
    Ion channel transport1.00
    Stimuli-sensing channels0.49
    3Hepatic ABC Transporters
    Hepatic ABC Transporters1.00
    4SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLCN6
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    3        Reactome Pathways for CLCN6
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    CLCN6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLCN6

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport NAS8543009
    GO:0006884cell volume homeostasis NAS8543009
    GO:0007165signal transduction NAS9224655


    CLCN6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLCN6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLCN6

    1 HMDB Compound for CLCN6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    1 Novoseek chemical compound relationship for CLCN6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 65.2 6 9480924 (2), 9224655 (2), 14761608 (1)

    3 PharmGKB related drug/compound annotations for CLCN6 gene
    Drug/compound PharmGKB Annotation
    antipsychoticsCA  
    carboplatinCA  
    methotrexateCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about CLCN6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLCN6 gene (5 alternative transcripts): 
    NM_001256959.1  NM_001286.3  NM_021735.2  NM_021736.2  NM_021737.2  

    Unigene Cluster for CLCN6:

    Chloride channel, voltage-sensitive 6
    Hs.193043  [show with all ESTs]
    Unigene Representative Sequence: NM_001286
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346436(uc001ate.4 uc010oat.2 uc010oau.2) ENST00000376497
    ENST00000376496 ENST00000376490 ENST00000376491 ENST00000376492 ENST00000494028
    ENST00000376487 ENST00000312413(uc009vne.1 uc009vnf.1 uc009vng.1 uc009vnh.1)


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    hsa-miR-607 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-148b hsa-miR-330-5p hsa-miR-128 hsa-miR-301a hsa-miR-548s
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK289999.1 AK294764.1 AK307098.1 BC050457.1 BC117420.1 BC117424.1 BC143844.1 D28475.2 
    NR_046428.1 X83378.1 X96391.1 X99473.1 X99474.1 X99475.1 

    14 DOTS entries:

    DT.453278  DT.100773866  DT.91762463  DT.75151031  DT.92068841  DT.100785174  DT.95374433  DT.121440298 
    DT.121440367  DT.121440328  DT.40294011  DT.91734195  DT.91797040  DT.99974858 

    24/163 AceView cDNA sequences (see all 163):

    AI886848 AA321539 X99474 T28428 BX955352 AL707784 BQ776822 CA773433 
    BQ012884 AW190376 T97239 BE502239 BQ716147 F03382 AI656222 X99473 
    BX642754 BM726161 H87127 AW172703 BM715574 CA313082 BM557724 CN483515 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLCN6    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:              -                       -           -                 -                                         -                                             
    SP2:                                                  -                                                                                                         
    SP3:              -                       -                                                                                                                     
    SP4:                                      -           -                                                                                                         
    SP5:                                                                                                                          -     -                           

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for CLCN6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLCN6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGAATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CLCN6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLCN6

    SOURCE GeneReport for Unigene cluster: Hs.193043

    UniProtKB/Swiss-Prot: CLCN6_HUMAN, P51797
    Tissue specificity: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and
    coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CLCN6 gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CLCN61 chloride channel 6 81.39(n)
    93.43(a)
      419488  XM_417644.2  XP_417644.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLCN66
    --
    --
    89(a)
    34(a)
    1 ↔ 1
    possible ortholog
    GL344836.1(1378-17832)
    GL343207.1(1434237-1462800)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb95f012 Transcribed sequence with weak similarity to protein more 73.47(n)    57044375 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CLC-D1 chloride channel protein CLC-d 45.84(n)
    36.82(a)
      832693  NM_122525.2  NP_197996.1 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 10)
    chloride transporter, chloride channel family, put...
    chloride transporter, chloride channel family, put...
    (see all 10)
    9(a)
    9(a)
    (see all 10)
    possible ortholog
    possible ortholog
    (see all 10)
    1(29215854-29220762)
    2(29893379-29898211)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria clcB6
    clcA6
    chloride channel, voltage-gated
    18(a)
    17(a)
    possible ortholog
    1 ↔ many
    Chromosome(1663339-1664595)
    Chromosome(175107-176528)


    ENSEMBL Gene Tree for CLCN6 (if available)
    TreeFam Gene Tree for CLCN6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLCN6 gene
    CLCN42  CLCNKB2  CLCN52  CLCN12  CLCN72  CLCN32  CLCNKA2  CLCN22  
    2 SIMAP similar genes for CLCN6 using alignment to 4 protein entries:     CLCN6_HUMAN (see all proteins):
    CLCN1    CLCN7

    CLCN6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/947 NCBI SNPs in CLCN6 are shown (see all 947    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776129241,2
    C,--11020107(+) TAAGGG/TCGCAC 3 -- us2k12Minor allele frequency- T:0.06CSA WA 120
    rs38340451,2
    C--11020121(-) AGCAA-/GCAA  
            
    TTAAC
    3 -- us2k1 tfbs30--------
    rs455040951,2
    C,F,--11020398(-) TGAATG/ATTGGC 3 -- us2k16Minor allele frequency- A:0.03NA WA CSA 1084
    rs37535821,2
    C,F,H,--11020599(-) GGCGAT/GCACCT 3 -- us2k18Minor allele frequency- G:0.10EA NS NA 2434
    rs454864931,2
    C,--11020642(-) GCCGAG/AACGGC 3 -- us2k11Minor allele frequency- A:0.00--476
    rs456108371,2
    C,F--11020705(-) CCCGTG/ATCCTC 3 -- us2k12Minor allele frequency- A:0.00--960
    rs454408991,2
    C,--11020721(-) CTCTGA/GCCGGC 3 -- us2k14Minor allele frequency- G:0.03NA WA 1080
    rs1137218041,2
    --11020847(+) ATCCCG/ACGAAG 3 -- us2k12Minor allele frequency- A:0.02CSA WA 120
    rs133065611,2
    C,F,H,--11020861(-) CTCCCT/CTGCGC 3 -- us2k122Minor allele frequency- C:0.22NS EA NA WA CSA 5033
    rs455940361,2
    C,--11020874(-) GGGGGG/TCTGCC 3 -- us2k13Minor allele frequency- T:0.05NA 2882

    HapMap Linkage Disequilibrium report for CLCN6 (11866207 - 11903201 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CLCN6
         1 Indel: 44439

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLCN6
    DNA2.0 Custom Variant and Variant Library Synthesis for CLCN6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLCN6 for disorders           About GeneDecksing

    OMIM gene information: 602726    OMIM disorders: --

    5 diseases for CLCN6:    About MalaCards
    ceroid lipofuscinosis    neuronal ceroid-lipofuscinosis    lysosomal storage disease    hearing loss
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CLCN6:
    Neuronal ceroid lipofuscinosis
    Human Genome Epidemiology (HuGE) Navigator: CLCN6 (9 documents)

    Export disorders for CLCN6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLCN6 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CLCN6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family. (PubMed id 8543009)1, 2, 3 Brandt S. and Jentsch T.J. (1995)
    2. Alternative splicing of ClC-6 (a member of the ClC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific. (PubMed id 9224655)1, 2, 9 Eggermont J.... Nilius B. (1997)
    3. Expression of CLCN voltage-gated chloride channel genes in human blood vessels. (PubMed id 10198195)1, 2, 9 Lamb F.S....Schutte B.C. (1999)
    4. Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains. (PubMed id 17534424)1, 2 Ignoul S.... Eggermont J. (2007)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes. (PubMed id 10500249)1, 2 Kornak U.... Kubisch C. (1999)
    9. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    10. Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium. (PubMed id 11306429)1, 9 Lamb F.S....McCray P.B. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1185 HGNC: 2024 AceView: CLCN6 Ensembl:ENSG00000011021 euGenes: HUgn1185
    ECgene: CLCN6 H-InvDB: CLCN6

    (According to HUGE)
    About This Section
    HUGE: KIAA0046

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLCN6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLCN6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLCN6 gene:
    Search GeneIP for patents involving CLCN6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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