CLCN4 Gene
protein-coding GIFtS: 57
GCID: GC0XP010085
|
|
chloride channel, voltage-sensitive 4(Previous name: chloride channel 4 )
| |
Aliases
for CLCN4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chloride Channel, Voltage-Sensitive 41 2 | | Chloride Channel Protein 42 3 | | ClC-41 2 3 | | Chloride Transporter ClC-42 3 | | CLC41 2 | | ClC-4A2 | | Chloride Channel 41 2 | | H(+)/Cl(-) Exchange Transporter 42 |
Export aliases for CLCN4 gene to outside databasesPrevious GC identifers: GC0XP009154 GC0XP008940 GC0XP009471 GC0XP009536 GC0XP009934 GC0XP007954 |
Summaries
for CLCN4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLCN4:
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) whichdemonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in closeproximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on thehuman X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute tothe pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode differentproteins. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: CLCN4_HUMAN, P51793Function: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons
Gene Wiki entry for CLCN4
|
Genomic Views
for CLCN4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLCN4 gene promoter:
CREB CRE-BP1 deltaCREB ATF-2 c-Jun ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLCN4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLCN4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.3 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.3CLCN4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP010085: view genomic region
(about GC identifiers)
Start:
|
10,124,985 bp from pter |
End:
|
10,205,700 bp from pter |
Size:
|
80,716 bases |
Orientation:
|
plus strand |
|
Proteins
for CLCN4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLCN4_HUMAN, P51793 (See
protein sequence)Recommended Name: H(+)/Cl(-) exchange transporter 4 Size: 760 amino acids; 84917 Da
Subcellular location: Early endosome membrane; Multi-pass membrane protein (By similarity). Late endosome membrane;Multi-pass membrane protein (By similarity)
Miscellaneous: The CLC channel family contains both chloride channels and proton-coupled anion transporters thatexchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical forfamily members that function as antiporters
Secondary accessions: A1L3U1 Q9UBU1Explore the universe of human proteins at neXtProt for CLCN4: NX_P51793
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51793
CLCN4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243873.1 NP_001821.2
ENSEMBL proteins: ENSP00000370213 ENSP00000370209 ENSP00000403064 ENSP00000405754 Reactome Protein details: P51793
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0031901 | early endosome membrane |
IEA | -- | | GO:0031902 | late endosome membrane |
IEA | -- |
CLCN4 for ontologies About GeneDecksing
CLCN4 Antibody Products:
Assay Products for CLCN4: |
Protein
Domains /
Families
for CLCN4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLCN4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51793ProtoNet protein and cluster: P51793 3 Blocks protein families: IPB000644 CBS domain IPB001807 Chloride channel signature IPB002246 CLC-4 chloride channel signature
UniProtKB/Swiss-Prot: CLCN4_HUMAN, P51793Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamilySimilarity: Contains 2 CBS domains |
Function
for CLCN4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CLCN4_HUMAN, P51793Function: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons Genatlas biochemistry entry for CLCN4:chloride voltage-gated channel 4,brain and heart
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLCN4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLCN4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLCN4 (NM_001830) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLCN4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLCN4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCN4 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CLCN4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CLCN4:
Animal Models:
Mouse knock-out Clcn4-2Clcn4-tm1Tjj for CLCN4
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Clcn4-2):
CLCN4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CLCN4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of cAMP-Dependent PKA | | | 2 | Ion channel transport | | | 3 | Hepatic ABC Transporters | | | 4 | SLC-mediated transmembrane transport | | | 5 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLCN4
3 
Reactome Pathways for CLCN4
CLCN4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLCN4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/20 Interacting proteins for CLCN4 (P517933 ENSP000003702134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CLCN4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLCN4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CLCN4 for compounds About GeneDecksing
 Browse Tocris compounds for CLCN4
1 HMDB Compound for CLCN4 About this table
3 Novoseek chemical compound relationships for CLCN4 gene About this table
Search CenterWatch for drugs/clinical trials and news about CLCN4
|
Transcripts
for CLCN4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLCN4 gene (2 alternative transcripts): NM_001256944.1 NM_001830.3 Unigene Cluster for CLCN4: Chloride channel, voltage-sensitive 4 Hs.495674 [show with all ESTs]Unigene Representative Sequence: NM_0018304 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380833(uc004csy.4 uc011mid.2) ENST00000380829 ENST00000454850
ENST00000421085
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLCN4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLCN4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLCN4 (NM_001830) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLCN4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLCN4 |
Additional cDNA sequence: AB019432.1 AF052117.1 AF170492.1 AK225287.1 AK289564.1 AK299611.1 BC036068.1 BC130278.1 X77197.1 6 DOTS entries: DT.214138 DT.205149 DT.97839585 DT.101979299 DT.86854183 DT.75200160 24/74 AceView cDNA sequences (see all 74): AW892370 AA071195 BX116599 BX494810 AW292101 AA071201 AU125175 AU098794 F07643 F08394 AI864647 M79019 BC036068 AI758925 AI168107 BM712774 AF170492 BM676117 AB019432 AA297742 T17179 Z44338 CK003008 AI375170
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CLCN4 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLCN4
|
Expression
for CLCN4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLCN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CLCN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLCN4
SOURCE GeneReport for Unigene cluster: Hs.495674
UniProtKB/Swiss-Prot: CLCN4_HUMAN, P51793Tissue specificity: Abundant in skeletal muscle and also detectable in brain and heart
SABiosciences Custom PCR Arrays for CLCN4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLCN4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLCN4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLCN4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLCN4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCN4 |
Orthologs
for CLCN4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CLCN4 gene from 9/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CLCN41 |
chloride channel 4 |
81.27(n)
97.24(a) |
|
428005 XM_425575.3 XP_425575.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CLCN46 |
-- |
96(a) |
1 ↔ 1 |
3(118907147-118944719) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.124342 |
Transcribed sequence with strong similarity to protein refNP_001821.1 (H.sapiens) chloride channel 4; ClC-4 [Homo sapiens] less |
78.88(n) |
|
BX710282.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.79652 |
Transcribed sequence with moderate similarity to protein refNP_001821.1 (H.sapiens) chloride channel 4; ClC-4 [Homo sapiens] less |
78.41(n) |
|
57074445 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG52843 |
chloride channel |
57(a) |
|
72D5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
clh-56 |
CLC-type chloride cHannel family member (clh-5) |
51(a) |
1 → many |
II(9094618-9098784) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CLCF6CLCE6 |
chloride channel protein CLC-e |
12(a)12(a) |
possible orthologpossible ortholog |
1(20787134-20791189) 4(16835986-16839375) |
rice
(Oryza sativa) |
Liliopsida |
----(see all 3) |
chloride transporter, chloride channel family, put...chloride transporter, chloride channel family, put...(see all 3) |
13(a)12(a)(see all 3) |
possible orthologpossible ortholog(see all 3) |
1(29215854-29220762) 2(29893379-29898211) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
clcA6clcB6 |
chloride channel, voltage-gated |
18(a)18(a) |
1 ↔ manypossible ortholog |
Chromosome(175107-176528) Chromosome(1663339-1664595) |
ENSEMBL Gene Tree for CLCN4 (if available)
TreeFam Gene Tree for CLCN4 (if available) |
Paralogs
for CLCN4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLCN4 gene
- CLCNKB2 CLCN62 CLCN52 CLCN12 CLCN72 CLCN32 CLCNKA2 CLCN22
2 SIMAP similar genes for CLCN4 using alignment to 6 protein entries: CLCN4_HUMAN (see all proteins):CLCN5 CLCN3
CLCN4 for paralogs About GeneDecksing
|
Genomic Variants
for CLCN4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLCN4 (10124985 - 10205700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CLCN4
1 CNV: 4145
Locus Specific Mutation Databases (LSDB): CLCN4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLCN4 |
|
Disorders
/ Diseases
for CLCN4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLCN4 for disorders About GeneDecksing
OMIM gene information: 302910
OMIM disorders: --
14  diseases for CLCN4: About MalaCardsocular albinism albinism microphthalmia with linear skin defects cystic fibrosis
dent disease microphthalmia neuronitis osteopetrosis
nephrolithiasis fanconi syndrome epididymitis fibrosis
colon cancer hepatitis
1 disease from the University of Copenhagen DISEASES database for CLCN4:Ocular albinism 1 Novoseek disease relationship for CLCN4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cystic fibrosis |
19.7 |
1 |
10932070 (1) |
Export disorders for CLCN4 gene to outside databases
|
Publications
for CLCN4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLCN4 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with CLCN4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene from the Xp22.3 region shares homology with voltage-gated chloride channels. (PubMed id 8069296)1, 2, 3, 9 van Slegtenhorst M.A.... Ballabio A. (1994)
- Identification of an acid-activated Cl- channel from human skeletal muscles. (PubMed id 10564087)1, 2, 9 Kawasaki M....Sasaki S. (1999)
- Mutational analysis of CLC-5, cofilin and CLC-4 in pa tients with Dent's disease. (PubMed id 19546591)1, 9 Wu F....Thakker R.V. (2009)
- Gene trapping identifies chloride channel 4 as a nove l inducer of colon cancer cell migration, invasion and metastases. (PubMed id 20087350)1, 9 Ishiguro T....Boyd D.D. (2010)
- Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells. (PubMed id 16129671)1, 9 Huang L....Brand J.G. (2005)
- Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. (PubMed id 16034421)1, 9 Picollo A. and Pusch M. (2005)
- A new region of conservation is defined between human and mouse X chromosomes. (PubMed id 8661129)1, 9 Dinulos M.B....Disteche C.M. (1996)
- Expression of CLCN voltage-gated chloride channel genes in human blood vessels. (PubMed id 10198195)1, 9 Lamb F.S....Schutte B.C. (1999)
- Intragenic TaqI restriction fragment length polymorphism (RFLP) in CICN4, between the loci for X-linked ocular albinism (OA1) and microphthalmia with linear skin defects syndrome (MLS). (PubMed id 7759088)1, 9 Schnur R.E. and Wick P.A. (1995)
- Anion- and proton-dependent gating of ClC-4 anion/pro ton transporter under uncoupling conditions. (PubMed id 21354396)1 Orhan G....Alekov A.K. (2011)
|
External Searches for CLCN4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLCN4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLCN4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLCN4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLCN4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLCN4 gene:
Search GeneIP for patents involving CLCN4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLCN4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLCN4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLCN4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLCN4 | | | OriGene Protein Over-expression Lysate for CLCN4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLCN4 | | OriGene 3'-UTR Clone for CLCN4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLCN4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLCN4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLCN4 | | OriGene Custom Protein Services for CLCN4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLCN4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLCN4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLCN4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLCN4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLCN4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLCN4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CLCN4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CLCN4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCN4 |
|  |  |  | | | | ThermoFisher Antibodies for CLCN4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLCN4 |
|
|
|
|
