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CLCF1 Gene

protein-coding   GIFtS: 58
GCID: GC11M067131

Cardiotrophin-Like Cytokine Factor 1

(Previous name: CRLF1 associated cytokine-like factor 1)
  See CLCF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cardiotrophin-Like Cytokine Factor 11 2     NNT12 3
Novel Neurotrophin-11 2 3     B-Cell-Stimulating Factor 32 3
BSF32 3 5     Cold-Induced Sweating Syndrome 21
CLC2 3 5     CISS22
CRLF1 Associated Cytokine-Like Factor 11 2     NR62
B-Cell Stimulating Factor 31 2     B-Cell Stimulatory Factor 32
BSF-32 3     Neurotrophin-1/B-Cell Stimulating Factor-32
NNT-12 3     

External Ids:    HGNC: 174121   Entrez Gene: 235292   Ensembl: ENSG000001755057   OMIM: 6076725   UniProtKB: Q9UBD93   

Export aliases for CLCF1 gene to outside databases

Previous GC identifers: GC11M066890 GC11M063460


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLCF1 Gene:
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1
(CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with
ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and
activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with
soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and
neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating
syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as
congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript
variants encoding distinct isoforms.(provided by RefSeq, Oct 2009)

GeneCards Summary for CLCF1 Gene:
CLCF1 (cardiotrophin-like cytokine factor 1) is a protein-coding gene. Diseases associated with CLCF1 include cold-induced sweating syndrome 1, and clcf1-related cold-induced sweating syndrome including crisponi syndrome. GO annotations related to this gene include cytokine activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: CLCF1_HUMAN, Q9UBD9
Function: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor

Gene Wiki entry for CLCF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLCF1 gene promoter:
         Sp1   STAT3   Nkx2-5   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLCF1 promoter sequence
   Search Chromatin IP Primers for CLCF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLCF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.3

CLCF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLCF1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067131:  view genomic region     (about GC identifiers)

Start:
67,131,639 bp from pter      End:
67,141,648 bp from pter
Size:
10,010 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLCF1_HUMAN, Q9UBD9 (See protein sequence)
Recommended Name: Cardiotrophin-like cytokine factor 1 precursor  
Size: 225 amino acids; 25176 Da
Secondary accessions: B4DNT4 Q6NZA4
Alternative splicing: 2 isoforms:  Q9UBD9-1   Q9UBD9-2   

Explore the universe of human proteins at neXtProt for CLCF1: NX_Q9UBD9

Explore proteomics data for CLCF1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29

  • See CLCF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159684.1  NP_037378.1  

    ENSEMBL proteins: 
     ENSP00000309338   ENSP00000434122   ENSP00000432553  

    CLCF1 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for CLCF1
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR010681 PRF

    Graphical View of Domain Structure for InterPro Entry Q9UBD9

    ProtoNet protein and cluster: Q9UBD9

    UniProtKB/Swiss-Prot: CLCF1_HUMAN, Q9UBD9
    Similarity: Belongs to the IL-6 superfamily


    Find genes that share domains with CLCF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLCF1_HUMAN, Q9UBD9
    Function: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI15272019
    GO:0005125cytokine activity NAS10500198
    GO:0005127contributes to ciliary neurotrophic factor receptor binding IDA10966616
    GO:0005515protein binding IPI10966616
    GO:0008083growth factor activity TAS14632778
         
    Find genes that share ontologies with CLCF1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CLCF1:
     Increased S DNA content  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clcf1):
     behavior/neurological  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with CLCF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Clcf1tm1Zou for CLCF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLCF1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLCF1 (see all 31):
    hsa-miR-217 hsa-miR-30c hsa-miR-185* hsa-miR-300 hsa-miR-509-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidCLCF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLCF1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLCF1_HUMAN, Q9UBD9: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    mitochondrion2
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS10448081
    GO:0005737cytoplasm ----
    GO:0097058CRLF-CLCF1 complex IDA10966616
    GO:0097059CNTFR-CLCF1 complex IDA11285233

    Find genes that share ontologies with CLCF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLCF1 About    
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    2Translation Insulin regulation of translation
    Development CNTF receptor signaling0.43
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway


    Find genes that share SuperPaths with CLCF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CLCF1
        Development CNTF receptor signaling



    2 Kegg Pathways  (Kegg details for CLCF1):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLCF1
    Interactions:

        GeneGlobe Interaction Network for CLCF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CLCF1 (Q9UBD93 ENSP000003093384) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNTFRP269923, ENSP000002423384I2D: score=2 STRING: ENSP00000242338
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    CRLF1O754623, ENSP000003761884I2D: score=2 STRING: ENSP00000376188
    PARK7Q994973, ENSP000003402784I2D: score=1 STRING: ENSP00000340278
    IL6STENSP000003387994STRING: ENSP00000338799
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002639positive regulation of immunoglobulin production ISS--
    GO:0007166cell surface receptor signaling pathway ISS--
    GO:0007259JAK-STAT cascade ISS--
    GO:0008284positive regulation of cell proliferation IDA10966616
    GO:0019221cytokine-mediated signaling pathway NAS10500198

    Find genes that share ontologies with CLCF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLCF1

    3 Novoseek inferred chemical compound relationships for CLCF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 86.8 11 14632778 (2), 10448081 (1), 15450249 (1), 20353755 (1)
    chloride 44.2 3 19309225 (1), 14729152 (1), 7665160 (1)
    tyrosine 16.1 2 10448081 (1), 14632778 (1)



    Find genes that share compounds with CLCF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLCF1 gene (2 alternative transcripts): 
    NM_001166212.1  NM_013246.2  

    Unigene Cluster for CLCF1:

    Cardiotrophin-like cytokine factor 1
    Hs.502977  [show with all ESTs]
    Unigene Representative Sequence: NM_013246
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312438(uc001okq.3 uc010rpp.2) ENST00000533438 ENST00000528474

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLCF1 (see all 31):
    hsa-miR-217 hsa-miR-30c hsa-miR-185* hsa-miR-300 hsa-miR-509-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidCLCF1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CLCF1
      QuantiFast Probe-based Assays in human, mouse, rat CLCF1

    Additional mRNA sequence: 

    AF172854.1 AF176911.1 AK298052.1 AY049779.1 BC012939.1 BC066229.1 BC066230.1 BC066231.1 

    4 DOTS entries:

    DT.40129080  DT.101956492  DT.91674727  DT.95296960 

    Selected AceView cDNA sequences (see all 411):

    AW149130 BP340895 AW140015 AW337446 AK097245 CK130211 CD674858 AA830376 
    BI832607 BM708105 BM668171 AA565206 AI797845 BU539052 BM263082 AW613022 
    BC066229 AA399224 F36077 AA928343 BE872590 CR592369 BF940520 AW137779 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLCF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTAAGTG
    CLCF1 Expression
    About this image


    CLCF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Stomach (Gastrointestinal Tract)
    CLCF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLCF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502977

    UniProtKB/Swiss-Prot: CLCF1_HUMAN, Q9UBD9
    Tissue specificity: Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and
    fetal liver

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLCF1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clcf11 , 5 cardiotrophin-like cytokine factor 11, 5 91.7(n)1
    96.89(a)1
      19 (3.91 cM)5
    567081  NM_019952.31  NP_064336.11 
     42142385 
    chicken
    (Gallus gallus)
    Aves CLCF11 cardiotrophin-like cytokine factor 1 74.16(n)
    70.51(a)
      100858060  XM_003643787.2  XP_003643835.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLCF16
    cardiotrophin-like cytokine factor 1
    63(a)
    1 ↔ 1
    1(93031859-93073686)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.322462 Xenopus laevis transcribed sequence with weak similarity to protein refNP_037378.1 (H.sapiens) cardiotrophin-like cytokine; neurotrophin-1/B-cell stimulating factor-3 [Homo sapiens] less 76.06(n)    BJ099801.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5622471 uncharacterized LOC562247 54.74(n)
    49.47(a)
      562247  XM_685641.5  XP_690733.5 


    ENSEMBL Gene Tree for CLCF1 (if available)
    TreeFam Gene Tree for CLCF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    5 SNPs for CLCF1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0283544
    Cold-induced sweating syndrome 2 (CISS2)4--see VAR_0283542 R L mis40--------
    rs1482890681,2
    C--67141459(+) GGCCT-/GTGGGA 1 -- int10--------
    rs614356241,2
    C--67141489(+) CCCTGC/-CCGAT 1 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs57924141,2
    ----67140097(+) ggggc-/GGGGGC
            
    ggggg
    2 -- int10--------
    rs57924151,2
    ----67140098(+) gggcg-/GGGGCG
            
    ggggc
    2 -- int10--------

    HapMap Linkage Disequilibrium report for CLCF1 (67131639 - 67141648 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CLCF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897796CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv468603CNV Loss19166990
    nsv897804CNV Gain21882294
    nsv7220OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): CLCF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLCF1
    DNA2.0 Custom Variant and Variant Library Synthesis for CLCF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607672   
    OMIM disorders: 610313  
    UniProtKB/Swiss-Prot: CLCF1_HUMAN, Q9UBD9
  • Cold-induced sweating syndrome 2 (CISS2) [MIM:610313]: An autosomal recessive disorder characterized by
    profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Patients manifest, in
    the neonatal period, orofacial weakness with impaired sucking and swallowing, resulting in poor feeding. Affected
    infants show a tendency to startle, with contractions of the facial muscles in response to tactile stimuli or
    during crying, trismus, abundant salivation, and opisthotonus. These features are referred to as Crisponi
    syndrome and can result in early death in infancy. Patients who survive into childhood have hyperhidrosis, mainly
    of the upper body, in response to cold temperatures, and sweat very little with heat. Additional abnormalities
    include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and
    kyphoscoliosis. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for CLCF1:    
    About MalaCards
    cold-induced sweating syndrome 1    clcf1-related cold-induced sweating syndrome including crisponi syndrome    cold-induced sweating syndrome including crisponi syndrome    cold-induced sweating syndrome
    crisponi syndrome


    Find genes that share disorders with CLCF1           About GenesLikeMe

    2 Novoseek inferred disease relationships for CLCF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cold-induced sweating syndrome 94.2 1 16782820 (1)
    leukemia 54.6 10 12773095 (1), 14506288 (1), 18953360 (1), 14632778 (1) (see all 6)


    Export disorders for CLCF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLCF1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with CLCF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. (PubMed id 16782820)1, 2, 3, 9 Rousseau F.... Boman H. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. (PubMed id 10448081)1, 2, 3, 9 Shi Y.... Alderson R.F. (Biochem. Biophys. Res. Commun. 1999)
    3. Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. (PubMed id 10500198)1, 2, 3 Senaldi G.... Chang M.-S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. (PubMed id 14632778)1, 9 Burger R....Anderson K.C. (Br. J. Haematol. 2003)
    6. Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. (PubMed id 15272019)1, 9 Perret D....Gascan H. (J. Biol. Chem. 2004)
    7. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain. (PubMed id 18728012)1, 9 Rousseau F....Gascan H. (J. Biol. Chem. 2008)
    8. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. (PubMed id 11294841)1, 9 LeliA"vre E....Gascan H. (J. Biol. Chem. 2001)
    9. Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3. (PubMed id 12639901)1, 9 Auernhammer C.J....Engelhardt D. (Endocrinology 2003)
    10. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. (PubMed id 17436251)1, 9 Dagoneau N....Cormier-Daire V. (Am. J. Hum. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23529 HGNC: 17412 AceView: CLCandPOLD4 Ensembl:ENSG00000175505 euGenes: HUgn23529
    ECgene: CLCF1 Kegg: 23529 H-InvDB: CLCF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLCF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLCF1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/289696/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLCF1 gene:
    Search GeneIP for patents involving CLCF1

    GeneCards and IP:
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