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Aliases for CLCF1 Gene

Aliases for CLCF1 Gene

  • Cardiotrophin-Like Cytokine Factor 1 2 3
  • Novel Neurotrophin-1 2 3 4
  • BSF3 3 4 6
  • CLC 3 4 6
  • CRLF1 Associated Cytokine-Like Factor 1 2 3
  • B-Cell Stimulating Factor 3 2 3
  • B-Cell-Stimulating Factor 3 3 4
  • BSF-3 3 4
  • NNT-1 3 4
  • NNT1 3 4
  • Neurotrophin-1/B-Cell Stimulating Factor-3 3
  • Cold-Induced Sweating Syndrome 2 2
  • B-Cell Stimulatory Factor 3 3
  • CISS2 3
  • NR6 3

External Ids for CLCF1 Gene

Previous GeneCards Identifiers for CLCF1 Gene

  • GC11M066890
  • GC11M067131
  • GC11M063460

Summaries for CLCF1 Gene

Entrez Gene Summary for CLCF1 Gene

  • This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

GeneCards Summary for CLCF1 Gene

CLCF1 (Cardiotrophin-Like Cytokine Factor 1) is a Protein Coding gene. Diseases associated with CLCF1 include cold-induced sweating syndrome 2 and cold-induced sweating syndrome. Among its related pathways are PEDF Induced Signaling and Translation Insulin regulation of translation. GO annotations related to this gene include protein heterodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot for CLCF1 Gene

  • Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.

Gene Wiki entry for CLCF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCF1 Gene

Genomics for CLCF1 Gene

Regulatory Elements for CLCF1 Gene

Genomic Location for CLCF1 Gene

67,364,168 bp from pter
67,374,177 bp from pter
10,010 bases
Minus strand

Genomic View for CLCF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLCF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCF1 Gene

Proteins for CLCF1 Gene

  • Protein details for CLCF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cardiotrophin-like cytokine factor 1
    Protein Accession:
    Secondary Accessions:
    • B4DNT4
    • Q6NZA4

    Protein attributes for CLCF1 Gene

    225 amino acids
    Molecular mass:
    25176 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLCF1 Gene


neXtProt entry for CLCF1 Gene

Proteomics data for CLCF1 Gene at MOPED

Post-translational modifications for CLCF1 Gene

  • Glycosylation at Asn29
  • Modification sites at PhosphoSitePlus

Other Protein References for CLCF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLCF1 Gene

Domains for CLCF1 Gene

Protein Domains for CLCF1 Gene

Suggested Antigen Peptide Sequences for CLCF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-6 superfamily.
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with CLCF1: view

No data available for Gene Families for CLCF1 Gene

Function for CLCF1 Gene

Molecular function for CLCF1 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.

Gene Ontology (GO) - Molecular Function for CLCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 15272019
GO:0005125 cytokine activity NAS 10500198
GO:0005127 contributes_to ciliary neurotrophic factor receptor binding IDA 10966616
GO:0005515 protein binding IPI 10966616
GO:0008083 growth factor activity TAS 14632778
genes like me logo Genes that share ontologies with CLCF1: view
genes like me logo Genes that share phenotypes with CLCF1: view

Animal Models for CLCF1 Gene

MGI Knock Outs for CLCF1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLCF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CLCF1 Gene

Localization for CLCF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCF1 Gene


Subcellular locations from

Jensen Localization Image for CLCF1 Gene COMPARTMENTS Subcellular localization image for CLCF1 gene
Compartment Confidence
extracellular 4
mitochondrion 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 10448081
GO:0005737 cytoplasm --
GO:0070062 extracellular exosome IDA 23376485
GO:0097058 CRLF-CLCF1 complex IDA 10966616
GO:0097059 CNTFR-CLCF1 complex IDA 11285233
genes like me logo Genes that share ontologies with CLCF1: view

Pathways for CLCF1 Gene

genes like me logo Genes that share pathways with CLCF1: view

Pathways by source for CLCF1 Gene

1 GeneGo (Thomson Reuters) pathway for CLCF1 Gene

Gene Ontology (GO) - Biological Process for CLCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002639 positive regulation of immunoglobulin production ISS --
GO:0007166 cell surface receptor signaling pathway ISS --
GO:0007259 JAK-STAT cascade ISS --
GO:0008284 positive regulation of cell proliferation IDA 10966616
GO:0019221 cytokine-mediated signaling pathway NAS 10500198
genes like me logo Genes that share ontologies with CLCF1: view

Drugs for CLCF1 Gene

(3) Novoseek inferred chemical compound relationships for CLCF1 Gene

Compound -log(P) Hits PubMed IDs
gp 130 86.8 5
chloride 44.2 3
tyrosine 16.1 2
genes like me logo Genes that share compounds with CLCF1: view

Transcripts for CLCF1 Gene

mRNA/cDNA for CLCF1 Gene

Unigene Clusters for CLCF1 Gene

Cardiotrophin-like cytokine factor 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLCF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLCF1 Gene

No ASD Table

Relevant External Links for CLCF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLCF1 Gene

mRNA expression in normal human tissues for CLCF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CLCF1 Gene

This gene is overexpressed in Monocytes (19.4), Urine (15.9), and Tlymphocyte (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLCF1 Gene

SOURCE GeneReport for Unigene cluster for CLCF1 Gene Hs.502977

mRNA Expression by UniProt/SwissProt for CLCF1 Gene

Tissue specificity: Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
genes like me logo Genes that share expressions with CLCF1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for CLCF1 Gene

Orthologs for CLCF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLCF1 35
  • 87.19 (n)
  • 89.66 (a)
CLCF1 36
  • 85 (a)
(Canis familiaris)
Mammalia CLCF1 35
  • 92.74 (n)
  • 97.78 (a)
CLCF1 36
  • 80 (a)
(Mus musculus)
Mammalia Clcf1 35
  • 91.7 (n)
  • 96.89 (a)
Clcf1 16
Clcf1 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Clcf1 35
  • 89.54 (n)
  • 95.96 (a)
(Monodelphis domestica)
Mammalia CLCF1 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia CLCF1 36
  • 79 (a)
(Pan troglodytes)
Mammalia CTF2 36
  • 29 (a)
(Gallus gallus)
Aves CLCF1 35
  • 74.16 (n)
  • 70.51 (a)
CLCF1 36
  • 68 (a)
(Anolis carolinensis)
Reptilia CLCF1 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clcf1 35
  • 60.9 (n)
  • 62.98 (a)
Str.16134 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32246 35
(Danio rerio)
Actinopterygii LOC562247 35
  • 54.74 (n)
  • 49.47 (a)
clcf1 36
  • 24 (a)
Species with no ortholog for CLCF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLCF1 Gene

Gene Tree for CLCF1 (if available)
Gene Tree for CLCF1 (if available)

Paralogs for CLCF1 Gene

No data available for Paralogs for CLCF1 Gene

Variants for CLCF1 Gene

Sequence variations from dbSNP and Humsavar for CLCF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_028354 Cold-induced sweating syndrome 2 (CISS2)

Structural Variations from Database of Genomic Variants (DGV) for CLCF1 Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
nsv468603 CNV Loss 19166990
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
nsv7220 OTHER Inversion 18451855

Relevant External Links for CLCF1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLCF1 Gene

Disorders for CLCF1 Gene

(1) OMIM Diseases for CLCF1 Gene (607672)


  • Cold-induced sweating syndrome 2 (CISS2) [MIM:610313]: An autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Patients manifest, in the neonatal period, orofacial weakness with impaired sucking and swallowing, resulting in poor feeding. Affected infants show a tendency to startle, with contractions of the facial muscles in response to tactile stimuli or during crying, trismus, abundant salivation, and opisthotonus. These features are referred to as Crisponi syndrome and can result in early death in infancy. Patients who survive into childhood have hyperhidrosis, mainly of the upper body, in response to cold temperatures, and sweat very little with heat. Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. {ECO:0000269 PubMed:16782820}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for CLCF1 Gene

Disease -log(P) Hits PubMed IDs
cold-induced sweating syndrome 94.2 1
leukemia 54.6 6
genes like me logo Genes that share disorders with CLCF1: view

No data available for University of Copenhagen DISEASES , Genatlas and External Links for CLCF1 Gene

Publications for CLCF1 Gene

  1. Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. (PMID: 10448081) Shi Y. … Alderson R.F. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. (PMID: 16782820) Rousseau F. … Boman H. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 23
  3. Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. (PMID: 10500198) Senaldi G. … Chang M.-S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  4. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain. (PMID: 18728012) Rousseau F. … Gascan H. (J. Biol. Chem. 2008) 3 23
  5. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. (PMID: 17436251) Dagoneau N. … Cormier-Daire V. (Am. J. Hum. Genet. 2007) 3 23

Products for CLCF1 Gene

Sources for CLCF1 Gene

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