CLCF1 Gene

Aliases
for CLCF1 gene

Previous GC identifers: GC11M066890 GC11M063460

Summaries
for CLCF1 gene

Genomic Views
for CLCF1 gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_167190.1  

SwitchGear Promoter luciferase reporter plasmid: CLCF1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLCF1

CLCF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067131:  view genomic region     (about GC identifiers)

Proteins
for CLCF1 gene

Explore the universe of human proteins at neXtProt for CLCF1: NX_Q9UBD9

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CLCF1 (CLC)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): CLCF1 OriGene Custom Protein Services for CLCF1
	GenScript Custom Purified and Recombinant Proteins Services for CLCF1
	Novus Biologicals CLCF1 Proteins Novus Biologicals CLCF1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CLCF1
	Uscn Proteins for CLCF1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CLCF1 (CLC)
	OriGene Antibodies: CLCF1 OriGene Custom Antibody Services for CLCF1
	GenScript Custom Superior Antibodies Services for CLCF1
	Novus Biologicals CLCF1 Antibodies
	Abcam antibodies for CLCF1
	Uscn Antibodies for CLCF1
	ThermoFisher Antibodies for CLCF1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CLCF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CLCF1

Protein Domains /
Families
for CLCF1 gene

ProtoNet protein and cluster: Q9UBD9

Function
for CLCF1 gene

     Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 1 allele) (MGI details for Clcf1)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLCF1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLCF1
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CLCF1 (see all 31):
		hsa-miR-217 hsa-miR-30c hsa-miR-185* hsa-miR-300 hsa-miR-509-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-515-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CLCF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLCF1 (see all 7) OriGene shRNA RFP: CLCF1 OriGene siRNA: CLCF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLCF1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CLCF1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CLCF1
			Sirion Biotech Customized adenovirus for overexpression of CLCF1  Sirion Biotech Customized adenovirus for potent knockdown of CLCF1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLCF1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLCF1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLCF1 (NM_013246)
		Sino Biological Human cDNA Clone for CLCF1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLCF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLCF1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CLCF1
		Search LifeMap BioReagents cell lines for CLCF1
		Sirion Biotech Customized stable knockdown cell line services for CLCF1  Sirion Biotech Customized inducible knockdown cell line services for CLCF1 Sirion Biotech Customized stable overexpressing cell line services for CLCF1 Sirion Biotech Customized inducible overexpressing cell line services for CLCF1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCF1

Pathways & Interactions
for CLCF1 gene

	Super-pathway	contained gene-specific pathways
1	Development_CNTF receptor signaling	Development CNTF receptor signaling 1.00 Development_CNTF receptor signaling 1.00
2	Jak-STAT signaling pathway	Jak-STAT signaling pathway 1.00
3	PEDF Induced Signaling	Cytokine-cytokine receptor interaction 0.26

1 EMD Millipore Pathway for CLCF1

Development CNTF receptor signaling

1 GeneGo (Thomson Reuters) Pathway for CLCF1

Development CNTF receptor signaling

2         Kegg Pathways  (Kegg details for CLCF1)

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

Drugs & Compounds
for CLCF1 gene

Transcripts
for CLCF1 gene

Expression
for CLCF1 gene

CLCF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCTAAGTG

About this image

CLCF1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayernGnG Amacrine Cells			Amacrine, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Posterior foregut-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLCF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLCF1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLCF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLCF1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCF1

Orthologs
for CLCF1 gene

Paralogs
for CLCF1 gene

Genomic Variants
for CLCF1 gene

10/191 NCBI SNPs in CLCF1 are shown (see all 191)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1048942031,2	C	pathogenic	67132695(-)	GTGGCG/TCTCGG	5	R L	mis1 int1		0	--	--	--	--
rs1875937061,2		--	67131151(+)	TGGCTA/TACACG	3	--	int1 ds5001		0	--	--	--	--
rs1928106891,2		--	67131363(+)	GAAAAC/TCGAAT	3	--	ds5001 int1		0	--	--	--	--
rs781700581,2		--	67131496(+)	GGTGCG/ACCCAT	3	--	ds5001 int1		2		CSA WA	119
rs1404505261,2		--	67131851(+)	TGGCT-/AATGGT	3	--	ut31 int1		0	--	--	--	--
rs1849269211,2		--	67131888(+)	GATACC/GCTGGG	3	--	ut31 int1		0	--	--	--	--
rs1443594151,2		--	67131961(+)	CAGCTC/GGGGTT	3	--	ut31 int1		0	--	--	--	--
rs2003598451,2		--	67131998(+)	TCCTG-/GGTCT          GGTCT	3	--	ut31 int1		0	--	--	--	--
rs1487965661,2		--	67132064(+)	GCACCC/TCCAAT	3	--	int1 ut31		0	--	--	--	--
rs729327281,2	C,F	--	67132425(+)	AGCTCG/AGTAGA	3	--	ut31 int1		1		NA	120

HapMap Linkage Disequilibrium report for CLCF1 (67131639 - 67141648 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CLCF1
     1 Inversion: 37127
Human Gene Mutation Database (HGMD): CLCF1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLCF1

DNA2.0 Custom Variant and Variant Library Synthesis for CLCF1

Disorders / Diseases
for CLCF1 gene

11 diseases for CLCF1

2 Novoseek disease relationships for CLCF1 gene    About this table

Publications
for CLCF1 gene

PubMed articles for CLCF1 gene, integrated from 9 sources (see all 37): (articles sorted by number of sources associating them with CLCF1)

Utopia: connect your pdf to the dynamic world of online information

1. Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. (PubMed id 16782820)^{1, 2, 3, 9} Rousseau F.... Boman H. (2006)
2. Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. (PubMed id 10448081)^{1, 2, 3, 9} Shi Y....Alderson R.F. (1999)
3. Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. (PubMed id 10500198)^{1, 2, 3} Senaldi G.... Chang M.-S. (1999)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. (PubMed id 14632778)^{1, 9} Burger R....Anderson K.C. (2003)
6. Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. (PubMed id 15272019)^{1, 9} Perret D....Gascan H. (2004)
7. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain. (PubMed id 18728012)^{1, 9} Rousseau F....Gascan H. (2008)
8. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. (PubMed id 11294841)^{1, 9} Lelievre E....Gascan H. (2001)
9. Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3. (PubMed id 12639901)^{1, 9} Auernhammer C.J....Engelhardt D. (2003)
10. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. (PubMed id 17436251)^{1, 9} Dagoneau N....Cormier-Daire V. (2007)

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for CLCF1 gene