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Aliases for CLCC1 Gene

Aliases for CLCC1 Gene

  • Chloride Channel CLIC-Like 1 2 3
  • Mid-1-Related Chloride Channel Protein 1 3 4
  • MCLC 3 4
  • Mid1-Related Chloride Channel (Yeast) 2
  • Chloride Channel CLIC-Like Protein 1 3
  • KIAA0761 4

External Ids for CLCC1 Gene

Previous GeneCards Identifiers for CLCC1 Gene

  • GC01M109185
  • GC01M108820
  • GC01M109472
  • GC01M107364

Summaries for CLCC1 Gene

GeneCards Summary for CLCC1 Gene

CLCC1 (Chloride Channel CLIC-Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CLCC1 Gene

  • Seems to act as a chloride ion channel.

Gene Wiki entry for CLCC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCC1 Gene

Genomics for CLCC1 Gene

Regulatory Elements for CLCC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLCC1 Gene

108,929,508 bp from pter
108,963,499 bp from pter
33,992 bases
Minus strand

Genomic View for CLCC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCC1 Gene

Proteins for CLCC1 Gene

  • Protein details for CLCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chloride channel CLIC-like protein 1
    Protein Accession:
    Secondary Accessions:
    • O94861
    • Q8WYP8
    • Q8WYP9
    • Q9BU25

    Protein attributes for CLCC1 Gene

    551 amino acids
    Molecular mass:
    62023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLCC1 Gene


neXtProt entry for CLCC1 Gene

Proteomics data for CLCC1 Gene at MOPED

Post-translational modifications for CLCC1 Gene

  • Ubiquitination at Lys414
  • Glycosylation at Thr407, Thr469, and Thr474
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CLCC1 Gene

Domains for CLCC1 Gene

Protein Domains for CLCC1 Gene


Suggested Antigen Peptide Sequences for CLCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96S66
  • Belongs to the chloride channel MCLC family.
genes like me logo Genes that share domains with CLCC1: view

No data available for Gene Families for CLCC1 Gene

Function for CLCC1 Gene

Molecular function for CLCC1 Gene

UniProtKB/Swiss-Prot Function:
Seems to act as a chloride ion channel.

Gene Ontology (GO) - Molecular Function for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IEA --
genes like me logo Genes that share ontologies with CLCC1: view

Animal Model Products

miRNA for CLCC1 Gene

miRTarBase miRNAs that target CLCC1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLCC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLCC1 Gene

Localization for CLCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCC1 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Nucleus.

Subcellular locations from

Jensen Localization Image for CLCC1 Gene COMPARTMENTS Subcellular localization image for CLCC1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CLCC1: view

Pathways for CLCC1 Gene

SuperPathways for CLCC1 Gene

No Data Available

Interacting Proteins for CLCC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000349456 Q96S66-CLCC1_HUMAN for CLCC1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with CLCC1: view

No data available for Pathways by source for CLCC1 Gene

Compounds for CLCC1 Gene

(1) HMDB Compounds for CLCC1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2
genes like me logo Genes that share compounds with CLCC1: view

Transcripts for CLCC1 Gene

Unigene Clusters for CLCC1 Gene

Chloride channel CLIC-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLCC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLCC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - -
SP4: -
SP6: - -
SP7: - - - -
SP8: - - - -

Relevant External Links for CLCC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLCC1 Gene

mRNA expression in normal human tissues for CLCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CLCC1 Gene

This gene is overexpressed in Breast (51.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLCC1 Gene

SOURCE GeneReport for Unigene cluster for CLCC1 Gene Hs.658489

genes like me logo Genes that share expressions with CLCC1: view

Expression partners for CLCC1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLCC1 Gene

Orthologs for CLCC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLCC1 35
  • 87.64 (n)
  • 82.02 (a)
CLCC1 36
  • 81 (a)
(Canis familiaris)
Mammalia CLCC1 35
  • 87.44 (n)
  • 80.88 (a)
CLCC1 36
  • 81 (a)
(Mus musculus)
Mammalia Clcc1 35
  • 79.85 (n)
  • 74.52 (a)
Clcc1 16
Clcc1 36
  • 74 (a)
(Pan troglodytes)
Mammalia CLCC1 35
  • 99.4 (n)
  • 99.09 (a)
CLCC1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Clcc1 35
  • 80.96 (n)
  • 74.19 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
-- 36
  • 60 (a)
(Gallus gallus)
Aves CLCC1 35
  • 65.24 (n)
  • 57.86 (a)
CLCC1 36
  • 57 (a)
(Anolis carolinensis)
Reptilia CLCC1 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clcc1 35
  • 59.42 (n)
  • 50.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397947 35
(Danio rerio)
Actinopterygii LOC100332460 35
  • 52.14 (n)
  • 43.57 (a)
CLCC1 36
  • 35 (a)
Species with no ortholog for CLCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLCC1 Gene

Gene Tree for CLCC1 (if available)
Gene Tree for CLCC1 (if available)

Paralogs for CLCC1 Gene

No data available for Paralogs for CLCC1 Gene

Variants for CLCC1 Gene

Sequence variations from dbSNP and Humsavar for CLCC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3517 -- 108,938,044(-) TGGAA(C/T)GCTCC intron-variant
rs168107 - 108,937,356(+) GGTTC(G/T)CTCTC missense, reference
rs170929 -- 108,941,779(+) ttccc(A/G)agtag intron-variant
rs186827 -- 108,935,905(-) CTCCG(G/T)GCTTA intron-variant
rs189263 -- 108,935,969(-) gcctg(A/G)aagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLCC1 Gene

Variant ID Type Subtype PubMed ID
dgv15n21 CNV Gain 19592680
nsv831026 CNV Loss 17160897
nsv526049 CNV Loss 19592680
esv2715940 CNV Deletion 23290073
nsv437236 CNV Loss 16327808
esv2662481 CNV Deletion 23128226
esv24963 CNV Loss 19812545
nsv441708 CNV CNV 18776908
esv2421924 CNV Deletion 20811451
nsv514000 CNV Loss 21397061

Relevant External Links for CLCC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLCC1 Gene

Disorders for CLCC1 Gene

Relevant External Links for CLCC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CLCC1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CLCC1 Gene

Publications for CLCC1 Gene

  1. Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus. (PMID: 11279057) Nagasawa M. … Kojima I. (J. Biol. Chem. 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 48
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for CLCC1 Gene

Sources for CLCC1 Gene

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