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Aliases for CLCC1 Gene

Aliases for CLCC1 Gene

  • Chloride Channel CLIC Like 1 2 3
  • Chloride Channel CLIC-Like 1 2 3 5
  • Mid-1-Related Chloride Channel Protein 1 3 4
  • MCLC 3 4
  • Mid1-Related Chloride Channel (Yeast) 2
  • KIAA0761 4

External Ids for CLCC1 Gene

Previous GeneCards Identifiers for CLCC1 Gene

  • GC01M109185
  • GC01M108820
  • GC01M109472
  • GC01M107364

Summaries for CLCC1 Gene

GeneCards Summary for CLCC1 Gene

CLCC1 (Chloride Channel CLIC Like 1) is a Protein Coding gene. GO annotations related to this gene include chloride channel activity.

UniProtKB/Swiss-Prot for CLCC1 Gene

  • Seems to act as a chloride ion channel.

Gene Wiki entry for CLCC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCC1 Gene

Genomics for CLCC1 Gene

Regulatory Elements for CLCC1 Gene

Enhancers for CLCC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLCC1 on UCSC Golden Path with GeneCards custom track

Promoters for CLCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLCC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLCC1 Gene

Chromosome:
1
Start:
108,929,508 bp from pter
End:
108,963,499 bp from pter
Size:
33,992 bases
Orientation:
Minus strand

Genomic View for CLCC1 Gene

Genes around CLCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCC1 Gene

Proteins for CLCC1 Gene

  • Protein details for CLCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S66-CLCC1_HUMAN
    Recommended name:
    Chloride channel CLIC-like protein 1
    Protein Accession:
    Q96S66
    Secondary Accessions:
    • O94861
    • Q8WYP8
    • Q8WYP9
    • Q9BU25

    Protein attributes for CLCC1 Gene

    Size:
    551 amino acids
    Molecular mass:
    62023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLCC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLCC1 Gene

Proteomics data for CLCC1 Gene at MOPED

Post-translational modifications for CLCC1 Gene

  • Ubiquitination at Lys 414
  • Glycosylation at Thr 407 and Thr 474
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLCC1 Gene

Domains & Families for CLCC1 Gene

Protein Domains for CLCC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S66

UniProtKB/Swiss-Prot:

CLCC1_HUMAN :
  • Belongs to the chloride channel MCLC family.
Family:
  • Belongs to the chloride channel MCLC family.
genes like me logo Genes that share domains with CLCC1: view

No data available for Gene Families for CLCC1 Gene

Function for CLCC1 Gene

Molecular function for CLCC1 Gene

UniProtKB/Swiss-Prot Function:
Seems to act as a chloride ion channel.

Phenotypes for CLCC1 Gene

genes like me logo Genes that share phenotypes with CLCC1: view

Animal Model Products

miRNA for CLCC1 Gene

miRTarBase miRNAs that target CLCC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLCC1 Gene

Localization for CLCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCC1 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLCC1 Gene COMPARTMENTS Subcellular localization image for CLCC1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
nucleus 3
plasma membrane 2
endosome 1

Gene Ontology (GO) - Cellular Components for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0034707 chloride channel complex IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CLCC1: view

Pathways & Interactions for CLCC1 Gene

SuperPathways for CLCC1 Gene

No Data Available

Interacting Proteins for CLCC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349456%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000349456 Q96S66-CLCC1_HUMAN for CLCC1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CLCC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLCC1 Gene

Drugs & Compounds for CLCC1 Gene

(1) Additional Compounds for CLCC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with CLCC1: view

Transcripts for CLCC1 Gene

Unigene Clusters for CLCC1 Gene

Chloride channel CLIC-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLCC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6: - -
SP7: - - - -
SP8: - - - -
SP9:

Relevant External Links for CLCC1 Gene

GeneLoc Exon Structure for
CLCC1
ECgene alternative splicing isoforms for
CLCC1

Expression for CLCC1 Gene

mRNA expression in normal human tissues for CLCC1 Gene

Protein differential expression in normal tissues from HIPED for CLCC1 Gene

This gene is overexpressed in Breast (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CLCC1 Gene



SOURCE GeneReport for Unigene cluster for CLCC1 Gene Hs.658489

genes like me logo Genes that share expression patterns with CLCC1: view

Protein tissue co-expression partners for CLCC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLCC1 Gene

Orthologs for CLCC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLCC1 35
  • 87.64 (n)
  • 82.02 (a)
CLCC1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLCC1 35
  • 87.44 (n)
  • 80.88 (a)
CLCC1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clcc1 35
  • 79.85 (n)
  • 74.52 (a)
Clcc1 16
Clcc1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLCC1 35
  • 99.4 (n)
  • 99.09 (a)
CLCC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clcc1 35
  • 80.96 (n)
  • 74.19 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves CLCC1 35
  • 65.24 (n)
  • 57.86 (a)
CLCC1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLCC1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clcc1 35
  • 59.42 (n)
  • 50.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397947 35
zebrafish
(Danio rerio)
Actinopterygii LOC100332460 35
  • 52.14 (n)
  • 43.57 (a)
CLCC1 36
  • 35 (a)
OneToOne
Species with no ortholog for CLCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLCC1 Gene

ENSEMBL:
Gene Tree for CLCC1 (if available)
TreeFam:
Gene Tree for CLCC1 (if available)

Paralogs for CLCC1 Gene

No data available for Paralogs for CLCC1 Gene

Variants for CLCC1 Gene

Sequence variations from dbSNP and Humsavar for CLCC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs168107 - 108,937,356(+) GGTTC(G/T)CTCTC reference, missense
rs3517 -- 108,938,044(-) TGGAA(C/T)GCTCC intron-variant
rs170929 -- 108,941,779(+) ttccc(A/G)agtag intron-variant
rs186827 -- 108,935,905(-) CTCCG(G/T)GCTTA intron-variant
rs189263 -- 108,935,969(-) gcctg(A/G)aagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLCC1 Gene

Variant ID Type Subtype PubMed ID
dgv15n21 CNV Gain 19592680
nsv831026 CNV Loss 17160897
nsv526049 CNV Loss 19592680
esv2715940 CNV Deletion 23290073
nsv437236 CNV Loss 16327808
esv2662481 CNV Deletion 23128226
esv24963 CNV Loss 19812545
nsv441708 CNV CNV 18776908
esv2421924 CNV Deletion 20811451
nsv514000 CNV Loss 21397061

Variation tolerance for CLCC1 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLCC1 Gene

Disorders for CLCC1 Gene

Relevant External Links for CLCC1

Genetic Association Database (GAD)
CLCC1
Human Genome Epidemiology (HuGE) Navigator
CLCC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLCC1

No disorders were found for CLCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLCC1 Gene

Publications for CLCC1 Gene

  1. Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus. (PMID: 11279057) Nagasawa M. … Kojima I. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CLCC1 Gene

Sources for CLCC1 Gene

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