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Aliases for CLCA4 Gene

Aliases for CLCA4 Gene

  • Chloride Channel Accessory 4 2 3
  • Chloride Channel, Calcium Activated, Family Member 4 2 3
  • Calcium-Activated Chloride Channel Family Member 4 3 4
  • Calcium-Activated Chloride Channel Protein 2 3 4
  • Chloride Channel Regulator 4 2 3
  • HCaCC-2 3 4
  • CaCC-2 3 4
  • HCLCA4 3 4
  • CaCC2 3 4
  • EC 3.4.-.- 4
  • CACC 3

External Ids for CLCA4 Gene

Previous GeneCards Identifiers for CLCA4 Gene

  • GC01P087514
  • GC01P086181
  • GC01P086305
  • GC01P086435
  • GC01P086724
  • GC01P087012
  • GC01P085123

Summaries for CLCA4 Gene

Entrez Gene Summary for CLCA4 Gene

  • The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]

GeneCards Summary for CLCA4 Gene

CLCA4 (Chloride Channel Accessory 4) is a Protein Coding gene. Diseases associated with CLCA4 include cystic fibrosis. Among its related pathways are Activation of cAMP-Dependent PKA and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include metallopeptidase activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is CLCA1.

UniProtKB/Swiss-Prot for CLCA4 Gene

  • May be involved in mediating calcium-activated chloride conductance

Gene Wiki entry for CLCA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCA4 Gene

Genomics for CLCA4 Gene

Regulatory Elements for CLCA4 Gene

Genomic Location for CLCA4 Gene

Chromosome:
1
Start:
86,547,076 bp from pter
End:
86,580,758 bp from pter
Size:
33,683 bases
Orientation:
Plus strand

Genomic View for CLCA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLCA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCA4 Gene

Proteins for CLCA4 Gene

  • Protein details for CLCA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CN2-CLCA4_HUMAN
    Recommended name:
    Calcium-activated chloride channel regulator 4
    Protein Accession:
    Q14CN2
    Secondary Accessions:
    • A8MQC9
    • B7Z1Q5
    • Q6UX81
    • Q9UNF7

    Protein attributes for CLCA4 Gene

    Size:
    919 amino acids
    Molecular mass:
    101283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLCA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLCA4 Gene

Proteomics data for CLCA4 Gene at MOPED

Post-translational modifications for CLCA4 Gene

  • The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
  • Glycosylation at Asn 75, Asn 340, Asn 504, Asn 542, Asn 588, Asn 628, Asn 811, Asn 832, Asn 837, and Asn 852
  • Modification sites at PhosphoSitePlus

Other Protein References for CLCA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLCA4 Gene

Domains & Families for CLCA4 Gene

Gene Families for CLCA4 Gene

Protein Domains for CLCA4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14CN2

UniProtKB/Swiss-Prot:

CLCA4_HUMAN :
  • The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates.
  • Belongs to the CLCR family.
Domain:
  • The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the CLCR family.
genes like me logo Genes that share domains with CLCA4: view

Function for CLCA4 Gene

Molecular function for CLCA4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in mediating calcium-activated chloride conductance
UniProtKB/Swiss-Prot Induction:
Down-regulated in oral tongue squamous cell carcinomas.

Enzyme Numbers (IUBMB) for CLCA4 Gene

Gene Ontology (GO) - Molecular Function for CLCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity IBA --
GO:0005254 chloride channel activity TAS 10437792
GO:0008237 metallopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CLCA4: view

Phenotypes for CLCA4 Gene

genes like me logo Genes that share phenotypes with CLCA4: view

Animal Model Products

CRISPR Products

miRNA for CLCA4 Gene

miRTarBase miRNAs that target CLCA4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLCA4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CLCA4 Gene

Localization for CLCA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCA4 Gene

Cell membrane; Single-pass membrane protein. Apical cell membrane. Secreted. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLCA4 Gene COMPARTMENTS Subcellular localization image for CLCA4 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CLCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10437792
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLCA4: view

Pathways & Interactions for CLCA4 Gene

genes like me logo Genes that share pathways with CLCA4: view

Interacting Proteins for CLCA4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359594%0d%0a9606.ENSP00000272602%0d%0a9606.ENSP00000369268%0d%0a
Selected Interacting proteins: ENSP00000359594 for CLCA4 Gene via STRING

Gene Ontology (GO) - Biological Process for CLCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006810 transport TAS 10437792
GO:0006821 chloride transport TAS 10437792
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with CLCA4: view

No data available for SIGNOR curated interactions for CLCA4 Gene

Drugs & Compounds for CLCA4 Gene

(1) Drugs for CLCA4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(1) Additional Compounds for CLCA4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with CLCA4: view

Transcripts for CLCA4 Gene

mRNA/cDNA for CLCA4 Gene

Unigene Clusters for CLCA4 Gene

Chloride channel accessory 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLCA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLCA4 Gene

No ASD Table

Relevant External Links for CLCA4 Gene

GeneLoc Exon Structure for
CLCA4
ECgene alternative splicing isoforms for
CLCA4

Expression for CLCA4 Gene

mRNA expression in normal human tissues for CLCA4 Gene

mRNA differential expression in normal tissues according to GTEx for CLCA4 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.8), Colon - Transverse (x13.3), and Minor Salivary Gland (x6.0).

Protein differential expression in normal tissues from HIPED for CLCA4 Gene

This gene is overexpressed in Cervix (39.6), Nasal epithelium (13.0), and Colon (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLCA4 Gene



SOURCE GeneReport for Unigene cluster for CLCA4 Gene Hs.567422

mRNA Expression by UniProt/SwissProt for CLCA4 Gene

Q14CN2-CLCA4_HUMAN
Tissue specificity: Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp.
genes like me logo Genes that share expression patterns with CLCA4: view

Protein tissue co-expression partners for CLCA4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CLCA4 Gene

Orthologs for CLCA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLCA4 35
  • 82.39 (n)
  • 75.6 (a)
CLCA4 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLCA4 35
  • 85.32 (n)
  • 79.91 (a)
CLCA4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI747448 35
  • 76.9 (n)
  • 71.54 (a)
Clca6 16
AI747448 36
  • 70 (a)
OneToMany
Clca6 36
  • 69 (a)
OneToMany
Gm6289 36
  • 70 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CLCA4 35
  • 98.95 (n)
  • 98.26 (a)
CLCA4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clca4 35
  • 76.67 (n)
  • 69.76 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-243k1.4 36
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for CLCA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLCA4 Gene

ENSEMBL:
Gene Tree for CLCA4 (if available)
TreeFam:
Gene Tree for CLCA4 (if available)

Paralogs for CLCA4 Gene

Paralogs for CLCA4 Gene

(3) SIMAP similar genes for CLCA4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CLCA4 Gene

genes like me logo Genes that share paralogs with CLCA4: view

Variants for CLCA4 Gene

Sequence variations from dbSNP and Humsavar for CLCA4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs709802 -- 86,564,299(-) GGTGA(C/T)AGCAC intron-variant
rs772600 -- 86,568,551(+) CAATT(C/T)CTCAG intron-variant
rs772601 -- 86,566,641(+) TGCAG(A/G)TAGTG intron-variant
rs772602 -- 86,566,247(+) TCCTC(C/T)AGAAA intron-variant
rs772603 -- 86,565,632(+) TTACC(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLCA4 Gene

Variant ID Type Subtype PubMed ID
nsv823464 CNV Loss 20364138
esv2670523 CNV Deletion 23128226

Variation tolerance for CLCA4 Gene

Residual Variation Intolerance Score: 21.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLCA4 Gene

HapMap Linkage Disequilibrium report
CLCA4
Human Gene Mutation Database (HGMD)
CLCA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLCA4 Gene

Disorders for CLCA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLCA4 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association
Search CLCA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLCA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLCA4
genes like me logo Genes that share disorders with CLCA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLCA4 Gene

Publications for CLCA4 Gene

  1. Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system. (PMID: 19210762) Piirsoo M. … Timmusk T. (BMC Dev. Biol. 2009) 23 67
  2. Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. (PMID: 19687122) Hwang S.J. … Ward S.M. (J. Physiol. (Lond.) 2009) 23 67
  3. Effect of NYD-SP27 down-regulation on ATP-induced Ca2+-dependent pancreatic duct anion secretion in cystic fibrosis cells. (PMID: 17196844) Zhu J.X. … Chan H.C. (Cell Biol. Int. 2007) 23 67
  4. Modulation of the Ca(2+)-activated Cl(-) channel by 14-3-3epsilon. (PMID: 10753667) Chan H.C. … Waye M.M. (Biochem. Biophys. Res. Commun. 2000) 23 67
  5. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PMID: 10437792) Agnel M. … Culouscou J.-M. (FEBS Lett. 1999) 2 67

Products for CLCA4 Gene

Sources for CLCA4 Gene

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