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CLCA4 Gene

protein-coding   GIFtS: 50
GCID: GC01P087012

Chloride Channel Accessory 4

(Previous names: chloride channel, calcium activated, family member 4, chloride...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chloride Channel Accessory 41 2     hCLCA42 3
Chloride Channel Regulator 41 2     hCaCC-22 3
Chloride Channel, Calcium Activated, Family Member 41 2     CaCC2
Calcium-Activated Chloride Channel Family Member 42 3     caCC-22
Calcium-Activated Chloride Channel Protein 22 3     Calcium-Activated Chloride Channel Regulator 42
CaCC22 3     CaCC-23

External Ids:    HGNC: 20181   Entrez Gene: 228022   Ensembl: ENSG000000166027   UniProtKB: Q14CN23   

Export aliases for CLCA4 gene to outside databases

Previous GC identifers: GC01P087514 GC01P086181 GC01P086305 GC01P086435 GC01P086724 GC01P085123


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLCA4 Gene:
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date,
all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in
size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative
splicing results in multiple transcript variants, only one of which is thought to be protein coding. (provided by
RefSeq, Dec 2008)

GeneCards Summary for CLCA4 Gene:
CLCA4 (chloride channel accessory 4) is a protein-coding gene. Diseases associated with CLCA4 include cystic fibrosis, and bestrophinopathy. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is CLCA1.

UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2
Function: May be involved in mediating calcium-activated chloride conductance

Gene Wiki entry for CLCA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLCA4 gene promoter:
         Bach1   Bach2   POU3F1   NF-E2 p45   LCR-F1   Evi-1   FOXL1   S8   JunD   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLCA4 promoter sequence
   Search Chromatin IP Primers for CLCA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLCA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31-p22   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p31-p22

CLCA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLCA4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P087012:  view genomic region     (about GC identifiers)

Start:
87,012,759 bp from pter      End:
87,046,437 bp from pter
Size:
33,679 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2 (See protein sequence)
Recommended Name: Calcium-activated chloride channel regulator 4 precursor  
Size: 919 amino acids; 101283 Da
Secondary accessions: Q6UX81 Q9UNF7

Explore the universe of human proteins at neXtProt for CLCA4: NX_Q14CN2

Explore proteomics data for CLCA4 at MOPED

Post-translational modifications: 

  • Processed at a monobasic residue to yield a larger N-terminal and a smaller C-terminal cleavage products of 90 to
    110 and 30 to 35 kDa, respectively (By similarity)1
  • Glycosylation2 at Asn75, Asn340, Asn504, Asn542, Asn588, Asn628, Asn811, Asn832, Asn837, Asn852
  • Modification sites at PhosphoSitePlus

  • See CLCA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036260.2  
    ENSEMBL proteins: 
     ENSP00000359594   ENSP00000263723  

    CLCA4 Human Recombinant Protein Products:

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    Novus Biologicals CLCA4 Protein
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    Cloud-Clone Corp. Proteins for CLCA4

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    CLCA4 Assay Products:

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    Cloud-Clone Corp. ELISAs for CLCA4
    Cloud-Clone Corp. CLIAs for CLCA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013642 Cl_channel_Ca
     IPR004727 CaCC_prot
     IPR015394 DUF1973
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q14CN2

    ProtoNet protein and cluster: Q14CN2

    UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2
    Similarity: Belongs to the CLCR family
    Similarity: Contains 1 VWFA domain


    CLCA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLCA4_HUMAN, Q14CN2
    Function: May be involved in mediating calcium-activated chloride conductance
    Induction: Down-regulated in oral tongue squamous cell carcinomas

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity TAS10437792
    GO:0005515protein binding ----
         
    CLCA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLCA4:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Clca6 (no phenotypes)

    CLCA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clca6tm1Lex for CLCA4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLCA4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLCA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLCA4

    miRNA
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    miRTarBase miRNAs that target CLCA4:
    hsa-mir-128-3p (MIRT022037), hsa-mir-335-5p (MIRT018387)

    Block miRNA regulation of human, mouse, rat CLCA4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLCA4
    SwitchGear 3'UTR luciferase reporter plasmidCLCA4 3' UTR sequence
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLCA4_HUMAN, Q14CN2: Cell membrane; Single-pass membrane protein (By similarity). Apical cell membrane (By
    similarity). Secreted (By similarity). Note=The C-terminus 30 kDa form is anchored to the membrane (By
    similarity). The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral component of plasma membrane TAS10437792
    GO:0016324apical plasma membrane IEA--

    CLCA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLCA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Olfactory Signaling Pathway
    Olfactory transduction0.82
    3Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40
    5Pancreatic secretion
    Pancreatic secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLCA4
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    2 Kegg Pathways  (Kegg details for CLCA4):
        Olfactory transduction
    Pancreatic secretion


    CLCA4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLCA4
    Interactions:

        Search GeneGlobe Interaction Network for CLCA4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLCA4 (ENSP000003595944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNGA3ENSP000002726024STRING: ENSP00000272602
    CNGA4ENSP000003692684STRING: ENSP00000369268
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10437792
    GO:0006821chloride transport TAS10437792
    GO:1902476chloride transmembrane transport TAS10437792

    CLCA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLCA4

    2 HMDB Compounds for CLCA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLCA4 gene: 
    NM_012128.3  

    Unigene Cluster for CLCA4:

    Chloride channel accessory 4
    Hs.567422  [show with all ESTs]
    Unigene Representative Sequence: NM_012128
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370563(uc009wcs.3 uc009wct.3 uc009wcu.3) ENST00000496322
    ENST00000263723
    miRNA
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    GenScript: all cDNA clones in your preferred vector: CLCA4 (NM_012128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLCA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLCA4
    Primer
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    OriGene qPCR primer pairs and template standards for CLCA4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLCA4
      QuantiTect SYBR Green Assays in human, mouse, rat CLCA4
      QuantiFast Probe-based Assays in human, mouse, rat CLCA4

    Additional mRNA sequence: 

    AF127035.1 AK000072.1 AK000138.1 AK293766.1 AK307785.1 AK307898.1 AK314430.1 AY358470.1 
    BC113687.1 BC113689.1 NR_024602.1 

    6 DOTS entries:

    DT.75185406  DT.100702813  DT.121387413  DT.95243321  DT.100667467  DT.99933383 

    Selected AceView cDNA sequences (see all 31):

    AL698764 AY358470 AK000072 AW841718 AL602665 AI860838 CB117698 CA432953 
    CB851641 BM986909 BG216984 BX282096 BX504920 BM955724 BG286204 AK000138 
    BX479455 BG286238 AW511708 AF127035 NM_012128 BU680615 BM955723 BU930829 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLCA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATGTAAA
    CLCA4 Expression
    About this image

    CLCA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLCA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567422

    UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2
    Tissue specificity: Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in
    brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and
    submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLCA4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clca65
    AI7474481
    chloride channel calcium activated 65
    expressed sequence AI7474481
    76.9(n)1
    71.54(a)1
      3 (69.22 cM)5
    997091  NM_001033199.31  NP_001028371.11 
     1449524805 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    47(a)
    1 → many
    8(14894638-14910177)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 9)
    Uncharacterized protein
    (see all 9)
    47(a)
    47(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    4(97475496-97501040)
    4(97603405-97636130)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-243k1.46
    si:dkey-243k1.4
    41(a)
    many ↔ many
    15(14024540-14027775) ENSDARG00000087565


    ENSEMBL Gene Tree for CLCA4 (if available)
    TreeFam Gene Tree for CLCA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLCA4 gene
    CLCA12  CLCA22  
    3 SIMAP similar genes for CLCA4 using alignment to 3 protein entries:     CLCA4_HUMAN (see all proteins):
    CLCA1    CLCA3P    CLCA2

    CLCA4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLCA4
    PGOHUM00000244780


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLCA4 (see all 740)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726461291,2
    C,F--87010813(+) ATAGAC/TGAATG 2 -- us2k12Minor allele frequency- T:0.10WA EA 238
    rs1470825471,2
    C--87010814(+) TAGACA/GAATGG 2 -- us2k10--------
    rs1452735911,2
    --87011025(+) TAAATA/CTAAAA 2 -- us2k10--------
    rs604184351,2
    C--87011099(+) AAAGAC/TTTCAT 2 -- us2k10--------
    rs1860629501,2
    --87011294(+) CTCAAA/GCAAAT 2 -- us2k10--------
    rs1905307361,2
    --87011321(+) AACAGG/TCCCAT 2 -- us2k10--------
    rs27914761,2
    C,A,H--87011452(-) ggtatT/Cgcatt 2 -- us2k14Minor allele frequency- C:0.35NA WA EA 360
    rs1828473541,2
    --87011577(+) AACCAC/TTATGG 2 -- us2k10--------
    rs1883845681,2
    --87011670(+) CCAAGG/TTTGGT 2 -- us2k10--------
    rs1911249241,2
    --87011683(+) ATCACA/GAGTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLCA4 (87012759 - 87046437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLCA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670523CNV Deletion23128226
    nsv823464CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLCA4
    DNA2.0 Custom Variant and Variant Library Synthesis for CLCA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    10 diseases for CLCA4:    
    About MalaCards
    cystic fibrosis    bestrophinopathy    farber lipogranulomatosis    lipogranulomatosis
    cholera    squamous cell carcinoma    hiv-1    pancreatitis
    endotheliitis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CLCA4:
    Cystic fibrosis     Bestrophinopathy

    CLCA4 for disorders           About GeneDecksing


    Export disorders for CLCA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLCA4 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CLCA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PubMed id 10437792)1, 2, 3 Agnel M.... Culouscou J.-M. (FEBS Lett. 1999)
    2. The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. (PubMed id 15490240)1, 2 Ritzka M.... Tummler B. (Hum. Genet. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine. (PubMed id 23073314)1 Kolbe E.W....Stanke F. (Eur. J. Hum. Genet. 2013)
    5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    6. Transcriptomic dissection of tongue squamous cell carcinoma. (PubMed id 18254958)2 Ye H.... Zhou X. (BMC Genomics 2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    10. Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps. (PubMed id 16012037)2 Lee S.H.... Lee J.Y. (Acta Oto-Laryngol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22802 HGNC: 2018 AceView: CLCA4 Ensembl:ENSG00000016602 euGenes: HUgn22802
    ECgene: CLCA4 Kegg: 22802 H-InvDB: CLCA4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLCA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLCA4 gene:
    Search GeneIP for patents involving CLCA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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