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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLCA4 Gene

protein-coding   GIFtS: 50
GCID: GC01P087012

chloride channel accessory 4

(Previous names: chloride channel, calcium activated, family member 4, chloride...)
 Explore 8 diseases affiliated with
CLCA4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLCA4    

Aliases
for CLCA4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chloride Channel Accessory 41 2     HCLCA41
CaCC21 2 3     HCaCC-21
Chloride Channel Regulator 41 2     CaCC2
Chloride Channel, Calcium Activated, Family Member 41 2     CaCC-23
Calcium-Activated Chloride Channel Family Member 42 3     Calcium-Activated Chloride Channel Regulator 42
Calcium-Activated Chloride Channel Protein 22 3     CaCC-23

External Ids:    HGNC: 20181   Entrez Gene: 228022   Ensembl: ENSG000000166027   UniProtKB: Q14CN23   
ORGUL members:         
NONCODE:n407100    

Export aliases for CLCA4 gene to outside databases

Previous GC identifers: GC01P087514 GC01P086181 GC01P086305 GC01P086435 GC01P086724 GC01P085123


Summaries
for CLCA4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLCA4:
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all
members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size,
sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results
in multiple transcript variants, only one of which is thought to be protein coding. (provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2
Function: May be involved in mediating calcium-activated chloride conductance

Gene Wiki entry for CLCA4


Genomic Views
for CLCA4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLCA4 gene promoter:
         Bach1   Bach2   POU3F1   NF-E2 p45   LCR-F1   Evi-1   FOXL1   S8   JunD   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLCA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLCA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLCA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31-p22   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p31-p22

CLCA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLCA4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P087012:  view genomic region     (about GC identifiers)

Start:
 87,012,759 bp from pter      End:
 87,046,437 bp from pter
Size:
 33,679 bases      Orientation:
 plus strand

Proteins
for CLCA4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2 (See protein sequence)
Recommended Name: Calcium-activated chloride channel regulator 4 precursor  
Size: 919 amino acids; 101283 Da
Subcellular location: Cell membrane; Single-pass membrane protein (By similarity). Apical cell membrane (By
similarity). Secreted (By similarity). Note=The C-terminus 30 kDa form is anchored to the membrane (By similarity).
The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus (By similarity)
Secondary accessions: Q6UX81 Q9UNF7

Explore the universe of human proteins at neXtProt for CLCA4: NX_Q14CN2

Post-translational modifications:

  • Processed at a monobasic residue to yield a larger N-terminal and a smaller C-terminal cleavage products of 90 to 110
    • and 30 to 35 kDa, respectively (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14CN2

    • CLCA4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036260.2  
    ENSEMBL proteins: 
     ENSP00000359594   ENSP00000263723  

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    Uscn Proteins for CLCA4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral to plasma membrane TAS10437792
    GO:0016324apical plasma membrane IEA--


    CLCA4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLCA4

    Protein Domains /
    Families
    for CLCA4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLCA4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013642 Cl_channel_Ca
     IPR004727 CaCC_prot
     IPR015394 DUF1973
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q14CN2

    ProtoNet protein and cluster: Q14CN2

    UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2
    Similarity: Belongs to the CLCR family
    Similarity: Contains 1 VWFA domain


    Function
    for CLCA4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2
    Function: May be involved in mediating calcium-activated chloride conductance
    Induction: Down-regulated in oral tongue squamous cell carcinomas

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLCA4 (see all 4)
    OriGene shRNA RFP: CLCA4
    OriGene siRNA: CLCA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLCA4

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity TAS10437792


    CLCA4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLCA4:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Clca6tm1Lex for CLCA4
         1 MGI phenotypic allele for Clca6 (no phenotypes)

    CLCA4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLCA4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    2Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    3Pancreatic secretion
    		Pancreatic secretion1.00
    4Olfactory transduction
    		Olfactory transduction1.00
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Cholera Infection0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLCA4
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    2         Kegg Pathways  (Kegg details for CLCA4):
        Olfactory transduction
    Pancreatic secretion


    CLCA4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLCA4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLCA4 (ENSP000003595944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNGA3ENSP000002726024STRING: ENSP00000272602
    CNGA4ENSP000003692684STRING: ENSP00000369268
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10437792
    GO:0006821chloride transport TAS10437792


    CLCA4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLCA4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLCA4

    2 HMDB Compounds for CLCA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about CLCA4 

    Transcripts
    for CLCA4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLCA4 gene: 
    NM_012128.3  

    Unigene Cluster for CLCA4:

    Chloride channel accessory 4
    Hs.567422  [show with all ESTs]
    Unigene Representative Sequence: NM_012128
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370563(uc009wcs.3 uc009wct.3 uc009wcu.3) ENST00000496322
    ENST00000263723

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF127035.1 AK000072.1 AK000138.1 AK293766.1 AK307785.1 AK307898.1 AK314430.1 AY358470.1 
    BC113687.1 BC113689.1 NR_024602.1 

    6 DOTS entries:

    DT.75185406  DT.100702813  DT.121387413  DT.95243321  DT.100667467  DT.99933383 

    24/31 AceView cDNA sequences (see all 31):

    BM986909 CB851641 CB117698 AL602665 AY358470 AI860838 AK000072 CA432953 
    AW841718 AL698764 BG216984 BG286238 BM955724 BG286204 AF127035 NM_012128 
    BX282096 BU680615 BM955723 BX504920 AK000138 BX479455 AW511708 AL702555 

    GeneLoc Exon Structure


    Expression
    for CLCA4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLCA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATATGTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CLCA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLCA4

    SOURCE GeneReport for Unigene cluster: Hs.567422

    UniProtKB/Swiss-Prot: CLCA4_HUMAN, Q14CN2
    Tissue specificity: Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain,
    urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal
    gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp

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    In Situ
    Assay Products:     
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    Orthologs
    for CLCA4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLCA4 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Clca65
    AI7474481    		 chloride channel calcium activated 65
    expressed sequence AI7474481    		 76.97(n)1
    71.74(a)1    		   3 (69.22 cM)5
    997091  NM_001033199.31  NP_001028371.11 
     1449524805 
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 46(a)
    		 1 → many
    		 8(16664288-16678068)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 8)    		 --
    		 47(a)
    47(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 4(97534009-97558801)
    4(97477025-97500961)
    zebrafish
    (Danio rerio)    		 Actinopterygii clca11 chloride channel accessory 1 53.03(n)
    41.79(a)    		   334289  XM_002664564.2  XP_002664610.2 


    ENSEMBL Gene Tree for CLCA4 (if available)
    TreeFam Gene Tree for CLCA4 (if available) 

    Paralogs
    for CLCA4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLCA4 gene
    CLCA12  CLCA22  
    3 SIMAP similar genes for CLCA4 using alignment to 3 protein entries:     CLCA4_HUMAN (see all proteins):
    CLCA1    CLCA3P    CLCA2

    CLCA4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLCA4
    PGOHUM00000244780


    Genomic Variants
    for CLCA4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/547 NCBI SNPs in CLCA4 are shown (see all 547)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs726461291,2
    		C,F,--87010813(+) ATAGAC/TGAATG 2 -- us2k12Minor allele frequency- T:0.10WA EA 238
    rs1470825471,2
    		--87010814(+) TAGACA/GAATGG 2 -- us2k10--------
    rs1452735911,2
    		--87011025(+) TAAATA/CTAAAA 2 -- us2k10--------
    rs604184351,2
    		--87011099(+) AAAGAC/TTTCAT 2 -- us2k10--------
    rs1860629501,2
    		--87011294(+) CTCAAA/GCAAAT 2 -- us2k10--------
    rs1905307361,2
    		--87011321(+) AACAGG/TCCCAT 2 -- us2k10--------
    rs27914761,2
    		C,A,H,--87011452(-) GGTATT/CGCATT 2 -- us2k14Minor allele frequency- C:0.35NA WA EA 360
    rs1828473541,2
    		--87011577(+) AACCAC/TTATGG 2 -- us2k10--------
    rs1883845681,2
    		--87011670(+) CCAAGG/TTTGGT 2 -- us2k10--------
    rs1911249241,2
    		--87011683(+) ATCACA/GAGTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLCA4 (87012759 - 87046437 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLCA4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLCA4
    DNA2.0 Custom Variant and Variant Library Synthesis for CLCA4

    Disorders / Diseases
    for CLCA4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLCA4 for disorders           About GeneDecksing

    8 diseases for CLCA4:    About MalaCards
    farber lipogranulomatosis    bestrophinopathy    lipogranulomatosis    cystic fibrosis
    squamous cell carcinoma    fibrosis    carcinoma    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for CLCA4:
    Cystic fibrosis     Bestrophinopathy

    Export disorders for CLCA4 gene to outside databases

    Publications
    for CLCA4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLCA4 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with CLCA4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PubMed id 10437792)1, 2, 3 Agnel M.... Culouscou J.-M. (1999)
    2. The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. (PubMed id 15490240)1, 2 Ritzka M.... Tummler B. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Transcriptomic dissection of tongue squamous cell carcinoma. (PubMed id 18254958)2 Ye H.... Zhou X. (2008)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    7. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)2 Ramachandran P....Loo J.A. (2006)
    8. Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps. (PubMed id 16012037)2 Lee S.H.... Lee J.Y. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CLCA4 gene

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    Genome Databases showing CLCA4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22802 HGNC: 2018 AceView: CLCA4 Ensembl:ENSG00000016602 euGenes: HUgn22802
    ECgene: CLCA4 Kegg: 22802 H-InvDB: CLCA4

    Other Databases showing CLCA4 gene

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    Specialized Databases showing CLCA4 gene

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    PharmGKB entry for CLCA4 Pharmacogenomics, SNPs, Pathways

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