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Aliases for CLCA3P Gene

Aliases for CLCA3P Gene

  • Chloride Channel Accessory 3, Pseudogene 2 3
  • CLCA3 3 4 6
  • Chloride Channel, Calcium Activated, Family Member 3 2 3
  • Calcium-Activated Chloride Channel Family Member 3 4
  • Chloride Channel Accessory 3 (Pseudogene) 3
  • Chloride Channel Regulator 3 Pseudogene 3
  • Chloride Channel Regulator 3 2
  • HCLCA3 4

External Ids for CLCA3P Gene

Previous Symbols for CLCA3P Gene

  • CLCA3

Summaries for CLCA3P Gene

Entrez Gene Summary for CLCA3P Gene

  • This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding. [provided by RefSeq, Jan 2009]

GeneCards Summary for CLCA3P Gene

CLCA3P (Chloride Channel Accessory 3, Pseudogene) is a Pseudogene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include transporter activity and chloride channel activity.

Tocris Summary for CLCA3P Gene

  • Chloride channels are a family of anion-selective channels involved in a diverse range of biological processes including the regulation of the excitability of neurons, skeletal, cardiac and smooth muscle, cell volume regulation, transepithelial salt transport, the acidification of intra- and extracellular compartments. Ca2+-activated chloride channels (CaCCs) are widely expressed in both excitable and non-excitable cells, are activated by intracellular Ca2+, and modulated by CaMKII and calcineurin.

Gene Wiki entry for CLCA3P Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCA3P Gene

Genomics for CLCA3P Gene

Genomic Location for CLCA3P Gene

86,634,273 bp from pter
86,655,376 bp from pter
21,104 bases
Plus strand

Genomic View for CLCA3P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLCA3P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCA3P Gene

Regulatory Elements for CLCA3P Gene

Proteins for CLCA3P Gene

  • Protein details for CLCA3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-activated chloride channel regulator family member 3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CLCA3P Gene

    262 amino acids
    Molecular mass:
    29971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLCA3P Gene

Proteomics data for CLCA3P Gene at MOPED

Post-translational modifications for CLCA3P Gene

No data available for DME Specific Peptides for CLCA3P Gene

Domains for CLCA3P Gene

Protein Domains for CLCA3P Gene



  • Belongs to the CLCR family.:
    • Q9Y6N3
genes like me logo Genes that share domains with CLCA3P: view

No data available for Gene Families for CLCA3P Gene

Function for CLCA3P Gene

Gene Ontology (GO) - Molecular Function for CLCA3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 10095065
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
GO:0005262 calcium channel activity IEA --
genes like me logo Genes that share ontologies with CLCA3P: view

Phenotypes for CLCA3P Gene

GenomeRNAi human phenotypes for CLCA3P:
genes like me logo Genes that share phenotypes with CLCA3P: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLCA3P Gene

Localization for CLCA3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCA3P Gene


Gene Ontology (GO) - Cellular Components for CLCA3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 10095065
GO:0005886 plasma membrane TAS --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with CLCA3P: view

Pathways for CLCA3P Gene

genes like me logo Genes that share pathways with CLCA3P: view

Pathways by source for CLCA3P Gene

Interacting Proteins for CLCA3P Gene

Gene Ontology (GO) - Biological Process for CLCA3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10095065
GO:0034220 ion transmembrane transport TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0055085 transmembrane transport TAS --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CLCA3P: view

Compounds for CLCA3P Gene

(5) Tocris Compounds for CLCA3P Gene

Compound Action Cas Number
CFTRinh 172 Voltage-independent, selective CFTR chloride channel blocker [307510-92-5]
Chromanol 293B IKs blocker. Also blocks ICFTR [163163-23-3]
DCPIB Selective blocker of VSAC/ICl, swell. Inhibits glucose-stimulated insulin release [82749-70-0]
Lonidamine Mitochondrial hexokinase inhibitor [50264-69-2]
NPPB Inhibits calcium-sensitive chloride currents [107254-86-4]
genes like me logo Genes that share compounds with CLCA3P: view

Transcripts for CLCA3P Gene

mRNA/cDNA for CLCA3P Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLCA3P Gene

Chloride channel accessory 3, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLCA3P Gene

No ASD Table

Relevant External Links for CLCA3P Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLCA3P Gene

mRNA expression in normal human tissues for CLCA3P Gene

mRNA differential expression in normal tissues according to GTEx for CLCA3P Gene

This gene is overexpressed in Esophagus - Mucosa (26.0) and Minor Salivary Gland (7.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLCA3P Gene

SOURCE GeneReport for Unigene cluster for CLCA3P Gene Hs.673847

mRNA Expression by UniProt/SwissProt for CLCA3P Gene

Tissue specificity: Expressed in the lung, trachea, spleen, thymus and mammary gland.
genes like me logo Genes that share expressions with CLCA3P: view

Orthologs for CLCA3P Gene

Evolution for CLCA3P Gene

Gene Tree for CLCA3P (if available)
Gene Tree for CLCA3P (if available)

No data available for Orthologs for CLCA3P Gene

Paralogs for CLCA3P Gene

Selected SIMAP similar genes for CLCA3P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLCA3P: view

No data available for Paralogs for CLCA3P Gene

Variants for CLCA3P Gene

Sequence variations from dbSNP and Humsavar for CLCA3P Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs190529 -- 86,633,365(-) cccag(C/T)agggg upstream-variant-2KB
rs263473 -- 86,633,931(+) cacac(A/C)cactg upstream-variant-2KB
rs263474 -- 86,633,770(+) cttaa(A/G)ccggt upstream-variant-2KB
rs263475 -- 86,633,595(+) cttcc(C/T)ggctg upstream-variant-2KB
rs477326 -- 86,654,867(-) TTTGT(A/C/G/T)CTTCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CLCA3P Gene

Variant ID Type Subtype PubMed ID
esv2714407 CNV Deletion 23290073

Relevant External Links for CLCA3P Gene

HapMap Linkage Disequilibrium report

Disorders for CLCA3P Gene

No disorders were found for CLCA3P Gene.

No data available for UniProtKB/Swiss-Prot for CLCA3P Gene

Publications for CLCA3P Gene

  1. Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels. (PMID: 10095065) Gruber A.D. … Pauli B.U. (Biochim. Biophys. Acta 1999) 2 3 4
  2. Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31). (PMID: 10584316) Gruber A.D. … Pauli B.U. (Genome 1999) 3
  3. Molecular characteristics and functional diversity of CLCA family members. (PMID: 11071307) Pauli B.U. … Elble R.C. (Clin. Exp. Pharmacol. Physiol. 2000) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome. (PMID: 16354791) Walker N.M. … Clarke L.L. (J. Pharmacol. Exp. Ther. 2006) 23

Products for CLCA3P Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CLCA3P
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CLCA3P
    • Block miRNA regulation of CLCA3P using miScript Target Protectors

    Sources for CLCA3P Gene

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