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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLCA2 Gene

protein-coding   GIFtS: 57
GCID: GC01P086889

chloride channel accessory 2

(Previous names: chloride channel, calcium activated, family member 2, chloride...)
 Explore 11 diseases affiliated with
CLCA2 via our new
 Human Malady Compendium 
Biological research products
for CLCA2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chloride Channel Accessory 21 2     CaCC-32 3
CLCRG21 2     HCLCA21
Chloride Channel Regulator 21 2     HCaCC-31
Chloride Channel, Calcium Activated, Family Member 21 2     CACC2
Calcium-Activated Chloride Channel Family Member 22 3     Calcium-Activated Chloride Channel Regulator 22
Calcium-Activated Chloride Channel Protein 32 3     Calcium-Activated Chloride Channel-22
CACC32 3     CLCA Family Member 2, Chloride Channel Regulator2

External Ids:    HGNC: 20161   Entrez Gene: 96352   Ensembl: ENSG000001379757   OMIM: 6040035   UniProtKB: Q9UQC93   

Export aliases for CLCA2 gene to outside databases

Previous GC identifers: GC01P087392 GC01P086058 GC01P086182 GC01P086312 GC01P086601 GC01P085000


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLCA2:
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all
members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size,
sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is
expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic
fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and
colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLCA2_HUMAN, Q9UQC9
Function: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and
cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor
suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung
metastasis via the binding to ITGB4

Gene Wiki entry for CLCA2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLCA2 gene promoter:
         GR   Pbx1a   GR-beta   FOXD3   Tal-1beta   FOXJ2 (long isoform)   ZID   GR-alpha   ITF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLCA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLCA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLCA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

CLCA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLCA2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P086889:  view genomic region     (about GC identifiers)

Start:
86,889,769 bp from pter      End:
86,922,241 bp from pter
Size:
32,473 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLCA2_HUMAN, Q9UQC9 (See protein sequence)
Recommended Name: Calcium-activated chloride channel regulator 2 precursor  
Size: 943 amino acids; 103941 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I
membrane protein. Cell junction
Subcellular location: Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Note=Remains associated
to the 35 kDa form until an unidentified event triggers the release
Secondary accessions: A8K2T3 Q9Y6N2

Explore the universe of human proteins at neXtProt for CLCA2: NX_Q9UQC9

Post-translational modifications:

  • The 141 kDa mature form is shedded, producing a 109 kDa form and a 35 kDa form1
  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQC9

  • CLCA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006527.1  
    ENSEMBL proteins: 
     ENSP00000359596  

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    Uscn Proteins for CLCA2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS10362588
    GO:0009925basal plasma membrane IEA--
    GO:0030054cell junction IEA--


    CLCA2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLCA2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013642 Cl_channel_Ca
     IPR004727 CaCC_prot
     IPR015394 DUF1973
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9UQC9

    ProtoNet protein and cluster: Q9UQC9

    UniProtKB/Swiss-Prot: CLCA2_HUMAN, Q9UQC9
    Similarity: Belongs to the CLCR family
    Similarity: Contains 1 VWFA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CLCA2_HUMAN, Q9UQC9
    Function: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and
    cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor
    suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung
    metastasis via the binding to ITGB4
    Induction: Significantly down-regulated in breast and colorectal cancer

         Genatlas biochemistry entry for CLCA2:
    chloride channel Ca2+ activated family member 2,outwardly rectifiying,expressed in lung,trachea,mammary
    gland,epithelial cells

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    hsa-miR-3163 hsa-miR-548w hsa-miR-548j hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidCLCA2 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IEA--
    GO:0015276ligand-gated ion channel activity IEA--


    CLCA2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Clca5):
     liver/biliary system 

    CLCA2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA1.00
    PKA Signaling0.56
    cAMP Pathway0.77
    2CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)1.00
    3Hepatic ABC Transporters
    Hepatic ABC Transporters1.00
    4Alpha6-Beta4 Integrin Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway1.00
    5Pancreatic secretion
    Pancreatic secretion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLCA2
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for CLCA2
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    1 BioSystems Pathway for CLCA2 
        Alpha6-Beta4 Integrin Signaling Pathway


    2         Kegg Pathways  (Kegg details for CLCA2):
        Olfactory transduction
    Pancreatic secretion


    CLCA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLCA2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CLCA2 (Q9UQC93 ENSP000003595964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB4P161443, ENSP000002001814I2D: score=1 STRING: ENSP00000200181
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    CNGA3ENSP000002726024STRING: ENSP00000272602
    CNGA4ENSP000003692684STRING: ENSP00000369268
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10362588
    GO:0006821chloride transport ----
    GO:0007155cell adhesion IEA--


    CLCA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLCA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CLCA2

    2 HMDB Compounds for CLCA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    1 Novoseek chemical compound relationship for CLCA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 45.4 3 10437792 (2), 15707651 (1)

    Search CenterWatch for drugs/clinical trials and news about CLCA2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLCA2 gene: 
    NM_006536.5  

    Unigene Cluster for CLCA2:

    Chloride channel accessory 2
    Hs.241551  [show with all ESTs]
    Unigene Representative Sequence: NM_006536
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370565(uc001dlr.4) ENST00000490884 ENST00000498802

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    hsa-miR-3163 hsa-miR-548w hsa-miR-548j hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
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    Additional cDNA sequence: 

    AB026833.1 AF043977.1 AF127980.1 AK290348.1 AK296719.1 AK307937.1 BC041096.1 

    4 DOTS entries:

    DT.435997  DT.40115271  DT.106056  DT.92466956 

    24/56 AceView cDNA sequences (see all 56):

    BX504441 BG675746 BP351753 AW173757 BG695888 AA430264 AA687942 BC041096 
    BG696011 AF127980 AA443258 NM_006536 BG678906 AA446075 BP351722 AL598508 
    AL602490 BG741082 AW080787 BX476731 AL599524 BE148589 AI354332 BX505224 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLCA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGCCACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CLCA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLCA2

    SOURCE GeneReport for Unigene cluster: Hs.241551

    UniProtKB/Swiss-Prot: CLCA2_HUMAN, Q9UQC9
    Tissue specificity: Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea
    and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea.
    Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing
    stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only
    epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during
    epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small
    pulmonary arteries, arterioles, and subpleural and interlobular venules

        SABiosciences Expression via Pathway-Focused PCR Array including CLCA2: 
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLCA2 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CLCA21 chloride channel, calcium activated, family member more 62.56(n)
    52.94(a)
      771009  XM_001234329.1  XP_001234330.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.151332 Transcribed sequence with weak similarity to protein more 75.9(n)    BX707609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BX927244.26
    CR925813.16
    (see all 3)
    --
    38(a)
    37(a)
    (see all 3)
    possible ortholog
    many ↔ many
    (see all 3)
    15(14174249-14179134)
    15(14024896-14027779)


    ENSEMBL Gene Tree for CLCA2 (if available)
    TreeFam Gene Tree for CLCA2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLCA2 gene
    CLCA42  CLCA12  
    3 SIMAP similar genes for CLCA2 using alignment to 1 protein entry:     CLCA2_HUMAN:
    CLCA3P    CLCA1    CLCA4

    CLCA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/691 NCBI SNPs in CLCA2 are shown (see all 691    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380326921,2
    C,Fother86913377(+) TTTATC/TCCATT 2 P S mis12Minor allele frequency- T:0.00NA EU 5873
    rs1807738371,2
    --86887788(+) ACAGAA/GCCTTT 1 -- us2k10--------
    rs2001207151,2
    --86887800(+) AGCTG-/CCCACA 1 -- us2k10--------
    rs1125079221,2
    C,--86887802(+) CTGCC-/AACACC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs561849721,2
    C,--86887851(+) AAAAAA/TCTAGG 1 -- us2k12Minor allele frequency- T:0.06WA 120
    rs1409478191,2
    --86887871(+) TCAGTC/TTGGGA 1 -- us2k10--------
    rs1446732581,2
    --86887954(+) CCCATA/TCTTCA 1 -- us2k10--------
    rs1385294061,2
    --86887967(+) GAGAGA/CACCAT 1 -- us2k10--------
    rs754354891,2
    F,--86888070(+) TTTACA/CCTATA 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1488134121,2
    --86888080(+) AACCCA/GGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLCA2 (86889769 - 86922241 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLCA2: --
    Human Gene Mutation Database (HGMD): CLCA2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLCA2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    CLCA2 for disorders           About GeneDecksing

    OMIM gene information: 604003    OMIM disorders: --

    11 diseases for CLCA2:    About MalaCards
    cystic fibrosis    breast cancer    fibrosis    bestrophinopathy
    sporadic breast cancer    meningioma    colorectal cancer    pancreatitis
    leukemia    prostatitis    breast and colorectal cancer

    2 diseases from the University of Copenhagen DISEASES database for CLCA2:
    Cystic fibrosis     Bestrophinopathy
    Genetic Association Database (GAD): CLCA2
    Human Genome Epidemiology (HuGE) Navigator: CLCA2 (5 documents)

    Export disorders for CLCA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLCA2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CLCA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PubMed id 10437792)1, 2, 9 Agnel M.... Culouscou J.-M. (1999)
    2. The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia. (PubMed id 15707651)1, 2, 9 Connon C.J.... Kinoshita S. (2005)
    3. The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment. (PubMed id 16873362)1, 2 Elble R.C.... Pauli B.U. (2006)
    4. Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium. (PubMed id 16158324)1, 2 Connon C.J.... Kinoshita S. (2006)
    5. The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis. (PubMed id 11320086)1, 2 Abdel-Ghany M.... Pauli B.U. (2001)
    6. Isolation and characterization of a Ca(2+)-activated chloride channel from human corneal epithelium. (PubMed id 11262615)1, 2 Itoh R.... Okubo K. (2000)
    7. Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland. (PubMed id 10362588)1, 2 Gruber A.D.... Pauli B.U. (1999)
    8. Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2. (PubMed id 10554024)1, 2 Gruber A.D. and Pauli B.U. (1999)
    9. Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia. (PubMed id 12612194)1, 9 Mall M....Kunzelmann K. (2003)
    10. Loss of breast epithelial marker hCLCA2 promotes epith elial-to-mesenchymal transition and indicates higher risk of metastasis. (PubMed id 21909135)1 Walia V....Elble R.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9635 HGNC: 2016 AceView: CLCA2 Ensembl:ENSG00000137975 euGenes: HUgn9635
    ECgene: CLCA2 Kegg: 9635 H-InvDB: CLCA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLCA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLCA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLCA2 gene:
    Search GeneIP for patents involving CLCA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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