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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLCA1 Gene

protein-coding GIFtS: 61
GCID: GC01P086934

chloride channel accessory 1

(Previous names: chloride channel, calcium activated, family member 1, chloride...)

Explore 16 diseases affiliated with
CLCA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chloride Channel Accessory 1¹ ²		HCLCA1¹
CLCRG1¹ ²		HCaCC-1¹
Chloride Channel Regulator 1¹ ²		CaCC¹
Chloride Channel, Calcium Activated, Family Member 1¹ ²		CACC²
Calcium-Activated Chloride Channel Family Member 1² ³		GOB5²
Calcium-Activated Chloride Channel Protein 1² ³		Calcium-Activated Chloride Channel Regulator 1²
CACC1² ³		Calcium-Dependent Chloride Channel-1²
CaCC-1² ³		CLCA Family Member 1, Chloride Channel Regulator²

External Ids:	HGNC: 2015¹	Entrez Gene: 1179²	Ensembl: ENSG00000016490⁷	OMIM: 603906⁵	UniProtKB: A8K7I4³

Export aliases for CLCA1 gene to outside databases

Previous GC identifers: GC01P087436 GC01P086103 GC01P086226 GC01P086356 GC01P086646 GC01P085045

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLCA1:

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this

gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and

predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a

precursor protein that is processed into two cell-surface-associated subunits, although the site at which the

precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating

calcium-activated chloride conductance in the intestine. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLCA1_HUMAN, A8K7I4

Function: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell

metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production

and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May

play a role as a tumor suppressor. Induces MUC5AC

Gene Wiki entry for CLCA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLCA1 gene promoter:
Sox5 MAZR POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 GATA-1 GATA-2 MZF-1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLCA1 promoter sequence

Search SABiosciences Chromatin IP Primers for CLCA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLCA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3

CLCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLCA1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P086934: view genomic region (about GC identifiers)

Start:	86,934,051 bp from pter	End:	86,965,977 bp from pter
Size:	31,927 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLCA1_HUMAN, A8K7I4 (See protein sequence)

Recommended Name: Calcium-activated chloride channel regulator 1 precursor

Size: 914 amino acids; 100226 Da

Subcellular location: Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side.

Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli

Secondary accessions: B2RAV5 O95151 Q5TDF4 Q9UNF6 Q9UPC6

Explore the universe of human proteins at neXtProt for CLCA1: NX_A8K7I4

Post-translational modifications:

Glycosylated¹

The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of

37-to 41-kDa proteins¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A8K7I4

CLCA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001276.2

ENSEMBL proteins:

ENSP00000234701 ENSP00000378200

Human Recombinant Protein Products for CLCA1:

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	Uscn Proteins for CLCA1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005887	integral to plasma membrane	TAS	9828122
GO:0016021	integral to membrane	--	--
GO:0030141	secretory granule	IEA	--
GO:0042589	zymogen granule membrane	--	--

CLCA1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLCA1 for domains About GeneDecksing

4 InterPro domains/families:

IPR013642 Cl_channel_Ca

IPR004727 CaCC_prot

IPR015394 DUF1973

IPR002035 VWF_A

Graphical View of Domain Structure for InterPro Entry A8K7I4

ProtoNet protein and cluster: A8K7I4

UniProtKB/Swiss-Prot: CLCA1_HUMAN, A8K7I4

Similarity: Belongs to the CLCR family

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CLCA1_HUMAN, A8K7I4

Function: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell

metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production

and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May

play a role as a tumor suppressor. Induces MUC5AC

Induction: By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent

manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive

mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by

TNF in upper airway mucosa

Genatlas biochemistry entry for CLCA1:

chloride channel Ca2+ activated families member 1,outwardly rectifying,exclusively expressed in intestinal basal

crypt,epithelia and goblet cells

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005254	chloride channel activity	TAS	9828122

CLCA1 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLCA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Hepatic ABC Transporters

Hepatic ABC Transporters

1.00

Alpha6-Beta4 Integrin Signaling Pathway

Alpha6-Beta4 Integrin Signaling Pathway

1.00

Pancreatic secretion

Pancreatic secretion

1.00

Olfactory transduction

Olfactory transduction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLCA1

	Cholera Infection
	Hepatic ABC Transporters
	PKA Signaling
	cAMP Pathway
	Activation of cAMP-Dependent PKA

1 BioSystems Pathway for CLCA1

Alpha6-Beta4 Integrin Signaling Pathway

2 Kegg Pathways (Kegg details for CLCA1):

	Olfactory transduction
	Pancreatic secretion

CLCA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CLCA1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for CLCA1 (A8K7I4³ ENSP00000234701⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CFTR	P13569³, ENSP00000003084⁴	I2D: score=1 STRING: ENSP00000003084
ITGB4	P16144³, ENSP00000200181⁴	I2D: score=1 STRING: ENSP00000200181
KCNMB1	Q16558³, ENSP00000274629⁴	I2D: score=2 STRING: ENSP00000274629
GRB2	P62993³	I2D: score=2
CNGA3	ENSP00000272602⁴	STRING: ENSP00000272602

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9828122
GO:0006816	calcium ion transport	IEA	--
GO:0006821	chloride transport	TAS	9828122
GO:0071456	cellular response to hypoxia	--	--

CLCA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CLCA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CLCA1 available from Tocris Bioscience About this table

Compound	Action	CAS #
DCEBIO	Activates Cl- conductance and hIK1 K+ channels	[60563-36-2]
9-AC	Chloride transport inhibitor	[723-62-6]
NPPB	Chloride channel blocker	[107254-86-4]
Talniflumate	Chloride channel blocker (hCLCA1/mCLCA3 and Cl-/HCO3- exchange)	[66898-62-2]

2 HMDB Compounds for CLCA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Chlorine	Cl2 (see all 13)	16887-00-6	--

6 Novoseek chemical compound relationships for CLCA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chloride	80.7	30	17426222 (2), 17637221 (2), 17698377 (2), 19307298 (2) (see all 22)
niflumic acid	77.9	3	17426222 (2)
h2dids	76.5	1	10981514 (1)
dids	69.1	2	16809466 (1), 18640110 (1)
atp	27.5	2	18586953 (1), 18083779 (1)
calcium	26.9	15	18083779 (2), 18640110 (2), 18586953 (1), 20095232 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about CLCA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLCA1 gene:

NM_001285.3

Unigene Cluster for CLCA1:

Chloride channel accessory 1

Hs.194659 [show with all ESTs]

Unigene Representative Sequence: AF039400

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000234701(uc001dls.1 uc001dlt.3) ENST00000495894 ENST00000394711

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Additional cDNA sequence:

AF039400.1 AF127036.1 AK024970.1 AK097057.1 AK291999.1 AK300858.1 AK314375.1

4 DOTS entries:

DT.429041 DT.100010086 DT.92419837 DT.121411591

24/48 AceView cDNA sequences (see all 48):

AI802693 AA508854 BP383054 AK097057 AA581198 AF039400 BP382843 BM986862

AI660234 BF083270 AI660957 BX480459 AK024970 BF083321 NM_001285 BP383013

BP383201 AA297150 AW009763 AW009764 BG195179 AF127036 AW361521 BP383220

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CLCA1 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15
SP1:																									-
SP2:									-		-
SP3:																													-

ECgene alternative splicing isoforms for CLCA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLCA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACAGCTCA

About this image

CLCA1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Heart

Dorsal Aorta

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm progenitor-like cells (Generation and expan...)

See CLCA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLCA1

SOURCE GeneReport for Unigene cluster: Hs.194659

UniProtKB/Swiss-Prot: CLCA1_HUMAN, A8K7I4

Tissue specificity: Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet

cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both

asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells.

Expressed in normal turbinate mucosa and nasal polyp. Expressed in

SABiosciences Expression via Pathway-Focused PCR Array including CLCA1:

Allergy & Asthma in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLCA1 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	46(a)	1 → many	8(16664288-16678068)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 8)	--	49(a) 47(a) (see all 8)	many ↔ many many ↔ many (see all 8)	4(97534009-97558801) 4(97507375-97528552)
zebrafish (Danio rerio)	Actinopterygii	CR925813.1⁶ BX927244.1⁶ (see all 3)	--	39(a) 36(a) (see all 3)	many ↔ many many ↔ many (see all 3)	15(14024896-14027779) 15(14142651-14152739)

ENSEMBL Gene Tree for CLCA1 (if available)
TreeFam Gene Tree for CLCA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CLCA1 gene

CLCA4² CLCA2²

2 SIMAP similar genes for CLCA1 using alignment to 1 protein entry: CLCA1_HUMAN:

CLCA4 CLCA2

CLCA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186439630^1,2		--	86932526(+)	`CCGGGC/GACTCA`	1	--	us2k¹		0	--	--	--	--
rs190847836^1,2		--	86932535(+)	`CAGTCA/GTTTGC`	1	--	us2k¹		0	--	--	--	--
rs4251686^1,2	H	--	86932559(+)	`CTATCC/TACTCC`	1	--	us2k¹		6		NS EA	1032
rs183000514^1,2		--	86932705(+)	`GTCTGC/GGGGGA`	1	--	us2k¹		0	--	--	--	--
rs4647842^1,2	F	--	86932719(+)	`GATCAC/TCTGTA`	1	--	us2k¹		2		NS	612
rs4647844^1,2	C,F	--	86932730(+)	`GAAGAT/AGAGAA`	1	--	us2k¹		7		NS NA EU CSA WA	818
rs187291432^1,2		--	86932783(+)	`AAGGCA/GTGGTT`	1	--	us2k¹		0	--	--	--	--
rs5744297^1,2	C,F,H	--	86932933(+)	`ATTCCC/GTCATT`	1	--	us2k¹		27		NA EU NS EA MN	2694
rs5744298^1,2	C,F,H	--	86933011(+)	`GGAACC/TCAGGC`	1	--	us2k¹		7		NA EU NS EA	504
rs192847920^1,2		--	86933175(+)	`TTTCCC/TTTTTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CLCA1 (86934051 - 86965977 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLCA1: --
Human Gene Mutation Database (HGMD): CLCA1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLCA1 for disorders           About GeneDecksing

OMIM gene information: 603906    OMIM disorders: --

16 diseases for CLCA1:    About MalaCards

chronic obstructive pulmonary disease bestrophinopathy cystic fibrosis allergic rhinitis

pulmonary disease ileus rhinitis bronchitis

fibrosis asthma sinusitis meningioma

colorectal cancer hypoxia pancreatitis leukemia

2 diseases from the University of Copenhagen DISEASES database for CLCA1:

Cystic fibrosis Asthma

5 Novoseek disease relationships for CLCA1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cystic fibrosis	66.4	8	10072771 (1), 18805094 (1), 12198094 (1), 15763242 (1) (see all 8)
asthma	36.1	5	18597857 (1), 17898169 (1), 15345696 (1), 16364194 (1) (see all 5)
pulmonary disease chronic obstructive	34.3	2	18597857 (1), 17637221 (1)
inflammation	13.9	3	20095232 (1), 16364194 (1)
tumors	0	6	11445004 (4), 17073633 (1)

Genetic Association Database (GAD): CLCA1
Human Genome Epidemiology (HuGE) Navigator: CLCA1 (10 documents)

Export disorders for CLCA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLCA1 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with CLCA1)

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Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. (PubMed id 9828122)^{1, 2, 3} Gruber A.D....Pauli B.U. (1998)
Association of the hCLCA1 gene with childhood and adult asthma. (PubMed id 15318163)^{1, 4, 9} Kamada F....Matsubara Y. (2004)
hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels. (PubMed id 15919655)^{1, 2} Gibson A....Thompson N. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. (PubMed id 11842292)^{1, 2} Toda M.... Hamid Q. (2002)
Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PubMed id 10437792)^{1, 2} Agnel M.... Culouscou J.-M. (1999)
Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1. (PubMed id 17426222)^{1, 9} Hegab A.E....Sekizawa K. (2007)
Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells. (PubMed id 16148052)^{1, 9} Jeulin C....Marano F. (2005)
Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. (PubMed id 11445004)^{2, 9} Bustin S.A.... Dorudi S. (2001)
Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents. (PubMed id 19307298)^{1, 9} Hamann M....Main M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1179	HGNC: 2015	AceView: CLCA1	Ensembl:ENSG00000016490	euGenes: HUgn1179
ECgene: CLCA1	Kegg: 1179	H-InvDB: CLCA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLCA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CLCA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CLCA1 gene:
Search GeneIP for patents involving CLCA1

GeneCards and IP:
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chloride channel accessory 1

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CLCA1 Gene

chloride channel accessory 1

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