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Aliases for CLCA1 Gene

Aliases for CLCA1 Gene

  • Chloride Channel Accessory 1 2 3
  • Chloride Channel, Calcium Activated, Family Member 1 2 3
  • Calcium-Activated Chloride Channel Family Member 1 3 4
  • Calcium-Activated Chloride Channel Protein 1 3 4
  • Chloride Channel Regulator 1 2 3
  • HCaCC-1 3 4
  • CaCC-1 3 4
  • HCLCA1 3 4
  • CACC1 3 4
  • CLCA Family Member 1, Chloride Channel Regulator 3
  • Calcium-Activated Chloride Channel Regulator 1 3
  • Calcium-Dependent Chloride Channel-1 3
  • EC 3.4.-.- 4
  • CLCRG1 3
  • CACC 3
  • GOB5 3

External Ids for CLCA1 Gene

Summaries for CLCA1 Gene

Entrez Gene Summary for CLCA1 Gene

  • This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLCA1 Gene

CLCA1 (Chloride Channel Accessory 1) is a Protein Coding gene. Diseases associated with CLCA1 include pulmonary disease, chronic obstructive and meconium ileus. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is CLCA4.

UniProtKB/Swiss-Prot for CLCA1 Gene

  • May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.

Tocris Summary for CLCA1 Gene

  • Chloride channels are a family of anion-selective channels involved in a diverse range of biological processes including the regulation of the excitability of neurons, skeletal, cardiac and smooth muscle, cell volume regulation, transepithelial salt transport, the acidification of intra- and extracellular compartments. Ca2+-activated chloride channels (CaCCs) are widely expressed in both excitable and non-excitable cells, are activated by intracellular Ca2+, and modulated by CaMKII and calcineurin.

Gene Wiki entry for CLCA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCA1 Gene

Genomics for CLCA1 Gene

Genomic Location for CLCA1 Gene

86,468,368 bp from pter
86,500,294 bp from pter
31,927 bases
Plus strand

Genomic View for CLCA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCA1 Gene

Regulatory Elements for CLCA1 Gene

Proteins for CLCA1 Gene

  • Protein details for CLCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-activated chloride channel regulator 1
    Protein Accession:
    Secondary Accessions:
    • B2RAV5
    • O95151
    • Q5TDF4
    • Q9UNF6
    • Q9UPC6

    Protein attributes for CLCA1 Gene

    914 amino acids
    Molecular mass:
    100226 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLCA1 Gene

Proteomics data for CLCA1 Gene at MOPED

Post-translational modifications for CLCA1 Gene

  • Glycosylated.
  • The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn503, Asn585, Asn770, Asn804, Asn810, Asn831, Asn836, and Asn890

Other Protein References for CLCA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLCA1 Gene

Domains for CLCA1 Gene

Protein Domains for CLCA1 Gene


  • The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates.:
    • A8K7I4
  • Contains 1 VWFA domain.:
    • A8K7I4
  • Belongs to the CLCR family.:
    • A8K7I4
genes like me logo Genes that share domains with CLCA1: view

No data available for Gene Families for CLCA1 Gene

Function for CLCA1 Gene

Molecular function for CLCA1 Gene

GENATLAS Biochemistry: chloride channel Ca2+ activated families member 1,outwardly rectifying,exclusively expressed in intestinal basal crypt,epithelia and goblet cells
UniProtKB/Swiss-Prot Function: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
UniProtKB/Swiss-Prot Induction: By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by TNF in upper airway mucosa.

Enzyme Numbers (IUBMB) for CLCA1 Gene

Gene Ontology (GO) - Molecular Function for CLCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity IBA --
GO:0005254 chloride channel activity TAS 9828122
GO:0005515 protein binding --
GO:0008237 metallopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CLCA1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLCA1 Gene

Localization for CLCA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCA1 Gene

Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

Subcellular locations from

Jensen Localization Image for CLCA1 Gene COMPARTMENTS Subcellular localization image for CLCA1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9828122
GO:0005902 microvillus IEA --
genes like me logo Genes that share ontologies with CLCA1: view

Pathways for CLCA1 Gene

genes like me logo Genes that share pathways with CLCA1: view

Pathways by source for CLCA1 Gene

Gene Ontology (GO) - Biological Process for CLCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006810 transport TAS 9828122
GO:0006816 calcium ion transport IEA --
GO:0006821 chloride transport TAS 9828122
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with CLCA1: view

Compounds for CLCA1 Gene

(5) Tocris Compounds for CLCA1 Gene

Compound Action Cas Number
CFTRinh 172 Voltage-independent, selective CFTR chloride channel blocker [307510-92-5]
Chromanol 293B IKs blocker. Also blocks ICFTR [163163-23-3]
DCPIB Selective blocker of VSAC/ICl, swell. Inhibits glucose-stimulated insulin release [82749-70-0]
Lonidamine Mitochondrial hexokinase inhibitor [50264-69-2]
NPPB Inhibits calcium-sensitive chloride currents [107254-86-4]

(2) HMDB Compounds for CLCA1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Cl2

(6) Novoseek inferred chemical compound relationships for CLCA1 Gene

Compound -log(P) Hits PubMed IDs
chloride 80.7 26
niflumic acid 77.9 2
h2dids 76.5 1
dids 69.1 2
atp 27.5 2
genes like me logo Genes that share compounds with CLCA1: view

Transcripts for CLCA1 Gene

mRNA/cDNA for CLCA1 Gene

Unigene Clusters for CLCA1 Gene

Chloride channel accessory 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLCA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: - -
SP3: -

Relevant External Links for CLCA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLCA1 Gene

mRNA expression in normal human tissues for CLCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLCA1 Gene

This gene is overexpressed in Colon - Transverse (30.4) and Small Intestine - Terminal Ileum (21.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLCA1 Gene

SOURCE GeneReport for Unigene cluster for CLCA1 Gene Hs.194659

mRNA Expression by UniProt/SwissProt for CLCA1 Gene

Tissue specificity: Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
genes like me logo Genes that share expressions with CLCA1: view

Orthologs for CLCA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLCA1 36
  • 99.27 (n)
  • 99.02 (a)
CLCA1 37
  • 99 (a)
(Bos Taurus)
Mammalia CLCA1 36
  • 84.75 (n)
  • 81.41 (a)
CLCA1 37
  • 82 (a)
(Canis familiaris)
Mammalia CLCA1 36
  • 85.33 (n)
  • 81.78 (a)
CLCA1 37
  • 82 (a)
(Mus musculus)
Mammalia Clca1 16
Clca3 36
  • 78.36 (n)
  • 76.13 (a)
Clca3 37
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 55 (a)
-- 37
  • 46 (a)
-- 37
  • 62 (a)
-- 37
  • 57 (a)
-- 37
  • 55 (a)
-- 37
  • 63 (a)
-- 37
  • 67 (a)
-- 37
  • 61 (a)
-- 37
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 44 (a)
-- 37
  • 43 (a)
-- 37
  • 53 (a)
-- 37
  • 57 (a)
(Rattus norvegicus)
Mammalia Clca1 36
  • 77.63 (n)
  • 75.94 (a)
(Gallus gallus)
Aves -- 37
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
-- 37
  • 47 (a)
-- 37
  • 49 (a)
-- 37
  • 40 (a)
-- 37
  • 47 (a)
-- 37
  • 44 (a)
-- 37
  • 44 (a)
-- 37
  • 44 (a)
-- 37
  • 44 (a)
(Danio rerio)
Actinopterygii clca1 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
-- 37
  • 34 (a)
-- 37
  • 26 (a)
-- 37
  • 37 (a)
-- 37
  • 28 (a)
Species with no ortholog for CLCA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLCA1 Gene

Gene Tree for CLCA1 (if available)
Gene Tree for CLCA1 (if available)

Paralogs for CLCA1 Gene

Paralogs for CLCA1 Gene

Selected SIMAP similar genes for CLCA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLCA1: view

Variants for CLCA1 Gene

Sequence variations from dbSNP and Humsavar for CLCA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs760115 -- 86,489,713(+) TCTAA(C/T)TCCCA intron-variant
rs909138 -- 86,488,188(+) GGCCA(C/G)AGATG intron-variant
rs909139 -- 86,488,342(+) ATTGG(A/C)AGAAG intron-variant
rs909140 -- 86,489,356(+) TGTGT(A/C)TAGGA intron-variant
rs926062 -- 86,499,931(+) AGTCC(C/T)GATGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CLCA1 Gene

Variant ID Type Subtype PubMed ID
esv2714396 CNV Deletion 23290073

Relevant External Links for CLCA1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CLCA1 Gene

(2) University of Copenhagen DISEASES for CLCA1 Gene

(5) Novoseek inferred disease relationships for CLCA1 Gene

Disease -log(P) Hits PubMed IDs
cystic fibrosis 66.4 8
asthma 36.1 5
pulmonary disease chronic obstructive 34.3 2
inflammation 13.9 2
tumors 0 5

Relevant External Links for CLCA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLCA1: view

No data available for UniProtKB/Swiss-Prot for CLCA1 Gene

Publications for CLCA1 Gene

  1. Association of the hCLCA1 gene with childhood and adult asthma. (PMID: 15318163) Kamada F. … Matsubara Y. (Genes Immun. 2004) 3 23 49
  2. Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. (PMID: 9828122) Gruber A.D. … Pauli B.U. (Genomics 1998) 2 3 4
  3. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PMID: 10437792) Agnel M. … Culouscou J.-M. (FEBS Lett. 1999) 3 4
  4. Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway. (PMID: 17698377) Wang K. … Deng Z.P. (Cell Biol. Int. 2007) 3 23
  5. Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents. (PMID: 19307298) Hamann M. … Main M. (J. Physiol. (Lond.) 2009) 3 23

Products for CLCA1 Gene

Sources for CLCA1 Gene

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