Aliases for CLCA1 Gene
External Ids for CLCA1 Gene
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLCA1 Gene
CLCA1 (Chloride Channel Accessory 1) is a Protein Coding gene. Diseases associated with CLCA1 include pulmonary disease, chronic obstructive and meconium ileus. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is CLCA4.
UniProtKB/Swiss-Prot for CLCA1 Gene
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Chloride channels are a family of anion-selective channels involved in a diverse range of biological processes including the regulation of the excitability of neurons, skeletal, cardiac and smooth muscle, cell volume regulation, transepithelial salt transport, the acidification of intra- and extracellular compartments. Ca2+-activated chloride channels (CaCCs) are widely expressed in both excitable and non-excitable cells, are activated by intracellular Ca2+, and modulated by CaMKII and calcineurin.