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Aliases for CLC Gene

Aliases for CLC Gene

  • Charcot-Leyden Crystal Galectin 2 3 5
  • Charcot-Leyden Crystal Protein 2 3 4
  • Eosinophil Lysophospholipase 2 3 4
  • Lysolecithin Acylhydrolase 2 3 4
  • Lectin, Galactoside-Binding, Soluble, 10 2 3
  • LGALS10A 3 4
  • LGALS10 3 4
  • Gal-10 3 4
  • Galectin 10 2
  • Galectin-10 3
  • LPPL_HUMAN 3
  • GAL10 3

External Ids for CLC Gene

Previous GeneCards Identifiers for CLC Gene

  • GC19M040862
  • GC19M040613
  • GC19M044897
  • GC19M044913
  • GC19M040221
  • GC19M036668

Summaries for CLC Gene

Entrez Gene Summary for CLC Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLC Gene

CLC (Charcot-Leyden Crystal Galectin) is a Protein Coding gene. Diseases associated with CLC include Celiac Disease and Autoinflammation, Lipodystrophy, And Dermatosis Syndrome. GO annotations related to this gene include carbohydrate binding and cysteine-type endopeptidase activity involved in apoptotic process. An important paralog of this gene is LGALS13.

UniProtKB/Swiss-Prot for CLC Gene

  • Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).

Gene Wiki entry for CLC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLC Gene

Genomics for CLC Gene

Regulatory Elements for CLC Gene

Enhancers for CLC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F039557 1.4 FANTOM5 Ensembl ENCODE 10.8 +179.6 179606 2.1 HDGF SIX4 IRF2 PKNOX1 SAP130 ARID4B FEZF1 GATA3 ZNF366 ZNF169 PLEKHG2 EID2B CLC DLL3 LEUTX MED29 LGALS4 RPS16 PAF1 ZFP36
GH19F039676 1.2 Ensembl ENCODE 10.9 +59.5 59457 3.6 HDGF TBP PKNOX1 TBL1XR1 SIN3A BMI1 YY1 ZNF121 EGR1 SCRT2 LGALS17A ENSG00000268088 LEUTX FBL CLC EID2B ZNF780A LGALS16
GH19F039738 0.7 FANTOM5 16.1 -1.0 -1024 0.1 ZNF263 ZNF280D FOSL1 ZFP69B ZBTB48 NCOR1 POLR2A ZNF138 IKZF1 PRDM10 CLC LEUTX
GH19F039677 1 FANTOM5 ENCODE 10.8 +61.9 61874 0.2 MTA2 ZBED1 JUNB TBX21 ZNF121 JUND EED IKZF1 NFE2 ETV6 LEUTX FBL CLC EID2B PLEKHG2 MED29 ZFP36 PAF1 LGALS17A LGALS16
GH19F039703 0.8 ENCODE 11.6 +32.5 32487 3.5 HDGF PKNOX1 TBL1XR1 ZNF384 EBF1 ZBTB40 HIC1 ZFHX2 POLR2A EED LGALS17A CLC EID2B LGALS14 ENSG00000278813
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLC on UCSC Golden Path with GeneCards custom track

Genomic Location for CLC Gene

Chromosome:
19
Start:
39,731,250 bp from pter
End:
39,738,029 bp from pter
Size:
6,780 bases
Orientation:
Minus strand

Genomic View for CLC Gene

Genes around CLC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLC Gene

Proteins for CLC Gene

  • Protein details for CLC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05315-LEG10_HUMAN
    Recommended name:
    Galectin-10
    Protein Accession:
    Q05315
    Secondary Accessions:
    • C5HZ13
    • C5HZ14
    • Q0VDE3

    Protein attributes for CLC Gene

    Size:
    142 amino acids
    Molecular mass:
    16453 Da
    Quaternary structure:
    • Interacts with CEL.
    Miscellaneous:
    • Forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions from sites of eosinophil-associated inflammation and some myeloid leukemias.

    Three dimensional structures from OCA and Proteopedia for CLC Gene

neXtProt entry for CLC Gene

Post-translational modifications for CLC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLC Gene

Domains & Families for CLC Gene

Gene Families for CLC Gene

Protein Domains for CLC Gene

Suggested Antigen Peptide Sequences for CLC Gene

Graphical View of Domain Structure for InterPro Entry

Q05315

UniProtKB/Swiss-Prot:

LEG10_HUMAN :
  • Contains 1 galectin domain.
Domain:
  • Contains 1 galectin domain.
genes like me logo Genes that share domains with CLC: view

Function for CLC Gene

Molecular function for CLC Gene

GENATLAS Biochemistry:
Charcot-Leyden crystal protein,eosinophil lysophospholipase,also expressed in basophil,galectin family of galactoride-beta binding protein
UniProtKB/Swiss-Prot Function:
Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).

Gene Ontology (GO) - Molecular Function for CLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 NOT contributes_to lysophospholipase activity IDA 11834744
GO:0005515 protein binding IPI 11834744
GO:0030246 carbohydrate binding IEA --
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IDA 17502455
genes like me logo Genes that share ontologies with CLC: view
genes like me logo Genes that share phenotypes with CLC: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLC Gene

Localization for CLC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLC Gene

Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLC gene
Compartment Confidence
cytosol 5
extracellular 3
nucleus 3
plasma membrane 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 17502455
genes like me logo Genes that share ontologies with CLC: view

Pathways & Interactions for CLC Gene

No Data Available

Interacting Proteins for CLC Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000221804%0d%0a9606.ENSP00000268668%0d%0a9606.ENSP00000370395%0d%0a9606.ENSP00000221566%0d%0a9606.ENSP00000368699%0d%0a
Selected Interacting proteins: ENSP00000221804 Q05315-LEG10_HUMAN for CLC Gene via STRING IID

Gene Ontology (GO) - Biological Process for CLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002667 regulation of T cell anergy IMP 17502455
GO:0002724 regulation of T cell cytokine production IMP 17502455
GO:0007275 multicellular organism development TAS 8400237
GO:0046006 regulation of activated T cell proliferation IMP 17502455
GO:0070231 T cell apoptotic process IDA 17502455
genes like me logo Genes that share ontologies with CLC: view

No data available for Pathways by source and SIGNOR curated interactions for CLC Gene

Drugs & Compounds for CLC Gene

(9) Drugs for CLC Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
N-Ethylmaleimide Experimental Pharma Target 0
Para-Mercury-Benzenesulfonic Acid Experimental Pharma Target 0
Choline alfoscerate Experimental Pharma 0
MYRISTIC ACID Experimental Pharma 0

(44) Additional Compounds for CLC Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(0:0/18:0)
  • 1-Hydroxy-2-Octadecanoyl-sn-glycero-3-phosphocholine
  • 1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine
  • Lysophosphatidylcholine
  • Stearoyl lysophosphatidylcholine
genes like me logo Genes that share compounds with CLC: view

Transcripts for CLC Gene

mRNA/cDNA for CLC Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLC Gene

Charcot-Leyden crystal protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLC Gene

No ASD Table

Relevant External Links for CLC Gene

GeneLoc Exon Structure for
CLC
ECgene alternative splicing isoforms for
CLC

Expression for CLC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLC Gene

This gene is overexpressed in Whole Blood (x47.6).

Protein differential expression in normal tissues from HIPED for CLC Gene

This gene is overexpressed in Neutrophil (44.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLC Gene



NURSA nuclear receptor signaling pathways regulating expression of CLC Gene:

CLC

SOURCE GeneReport for Unigene cluster for CLC Gene:

Hs.889

mRNA Expression by UniProt/SwissProt for CLC Gene:

Q05315-LEG10_HUMAN
Tissue specificity: Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level).
genes like me logo Genes that share expression patterns with CLC: view

Primer Products

No data available for Protein tissue co-expression partners for CLC Gene

Orthologs for CLC Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610880 34
  • 80.38 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
OneToMany
Species where no ortholog for CLC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLC Gene

ENSEMBL:
Gene Tree for CLC (if available)
TreeFam:
Gene Tree for CLC (if available)

Paralogs for CLC Gene

Paralogs for CLC Gene

(9) SIMAP similar genes for CLC Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CLC Gene

genes like me logo Genes that share paralogs with CLC: view

Variants for CLC Gene

Sequence variations from dbSNP and Humsavar for CLC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs117361485 Benign 39,731,420(+) GGGAG(A/C)TATCT reference, missense
rs1034995 -- 39,739,496(+) CAGTA(C/T)ATAGA upstream-variant-2KB
rs1034996 -- 39,739,555(+) TTCAA(A/G)AAATG upstream-variant-2KB
rs10402365 -- 39,735,143(+) ATTCC(C/T)ATGGT intron-variant
rs10407799 -- 39,730,899(+) TGTTC(C/T)TACTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CLC Gene

Variant ID Type Subtype PubMed ID
nsv9723 CNV loss 18304495
nsv579511 CNV loss 21841781
nsv1123254 CNV deletion 24896259
esv2758760 CNV gain 17122850
dgv3529n100 CNV loss 25217958

Variation tolerance for CLC Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLC Gene

Disorders for CLC Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLC Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
celiac disease
  • celiac sprue
autoinflammation, lipodystrophy, and dermatosis syndrome
  • jmp syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CLC in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLC

Genetic Association Database (GAD)
CLC
Human Genome Epidemiology (HuGE) Navigator
CLC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLC
genes like me logo Genes that share disorders with CLC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLC Gene

Publications for CLC Gene

  1. Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion. (PMID: 11834744) Ackerman S.J. … Acharya K.R. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PMID: 1577491) Mastrianni D.M. … Ackerman S.J. (Genomics 1992) 2 3 4 22 64
  3. CLC- a novel susceptibility gene for allergic rhinitis? (PMID: 19650845) Bryborn M. … Cardell L.O. (Allergy 2010) 3 22 46 64
  4. Galectin-10, eosinophils, and celiac disease. (PMID: 19758173) De Re V. … Canzonieri V. (Ann. N. Y. Acad. Sci. 2009) 3 4 22 64
  5. Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. (PMID: 17502455) Kubach J. … Jonuleit H. (Blood 2007) 3 4 22 64

Products for CLC Gene

Sources for CLC Gene

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