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CLC Gene

protein-coding   GIFtS: 56
GCID: GC19M040221

Charcot-Leyden Crystal Galectin

(Previous name: Charcot-Leyden crystal protein)
  See CLC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Charcot-Leyden Crystal Galectin1 2     101
Charcot-Leyden Crystal Protein1 2 3     galactoside-binding1
Eosinophil Lysophospholipase1 2 3     lectin1
Lysolecithin Acylhydrolase1 2 3     soluble1
Galectin 101 2     GAL102
Gal-102 3     LPPL_HUMAN2
LGALS102 3     galectin-102
LGALS10A2 3     Lectin, Galactoside-Binding, Soluble, 102

External Ids:    HGNC: 20141   Entrez Gene: 11782   Ensembl: ENSG000001052057   OMIM: 1533105   UniProtKB: Q053153   

Export aliases for CLC gene to outside databases

Previous GC identifers: GC19M040862 GC19M040613 GC19M044897 GC19M044913 GC19M036668


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLC Gene:
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids.
The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes
lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or
IgE-binding activities. It is both structurally and functionally related to the galectin family of
beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CLC Gene:
CLC (Charcot-Leyden crystal galectin) is a protein-coding gene. Diseases associated with CLC include cold-induced sweating syndrome 1. GO annotations related to this gene include cysteine-type endopeptidase activity involved in apoptotic process and carbohydrate binding. An important paralog of this gene is LGALS16.

UniProtKB/Swiss-Prot: LEG10_HUMAN, Q05315
Function: Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and
suppressive function of CD25-positive regulatory T-cells (Treg)

Gene Wiki entry for CLC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLC gene promoter:
         FOXI1   HFH-3   p53   HFH-1   STAT3   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLC promoter sequence
   Search Chromatin IP Primers for CLC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

CLC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040221:  view genomic region     (about GC identifiers)

Start:
40,221,890 bp from pter      End:
40,228,668 bp from pter
Size:
6,779 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LEG10_HUMAN, Q05315 (See protein sequence)
Recommended Name: Galectin-10  
Size: 142 amino acids; 16453 Da
Subunit: Interacts with CEL
Miscellaneous: Forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues and secretions
from sites of eosinophil-associated inflammation and some myeloid leukemias
Caution: Was originally thought to possess lysophospholipase activity but the absence of this activity has been
shown by PubMed:11834744
4 PDB 3D structures from and Proteopedia for CLC:
1G86 (3D)        1HDK (3D)        1LCL (3D)        1QKQ (3D)    
Secondary accessions: C5HZ13 C5HZ14 Q0VDE3

Explore the universe of human proteins at neXtProt for CLC: NX_Q05315

Explore proteomics data for CLC at MOPED


See CLC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001819.2  
ENSEMBL proteins: 
 ENSP00000221804  

CLC Human Recombinant Protein Products:

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Novus Biologicals CLC Lysate
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Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for CLC
Cloud-Clone Corp. Proteins for CLC

 
Search eBioscience for Proteins for CLC 

CLC Antibody Products:

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R&D Systems Antibodies for CLC (Galectin-10)
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Abcam antibodies for CLC
Cloud-Clone Corp. Antibodies for CLC
Search ThermoFisher Antibodies for CLC
LSBio Antibodies in human, mouse, rat for CLC

CLC Assay Products:

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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CLC
Cloud-Clone Corp. CLIAs for CLC
Search eBioscience for ELISAs for CLC 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LGALS: Lectins, galactoside-binding

3 InterPro protein domains:
 IPR001079 Galectin_CRD
 IPR013320 ConA-like_subgrp
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q05315

ProtoNet protein and cluster: Q05315

1 Blocks protein domain: IPB001079 Galectin

UniProtKB/Swiss-Prot: LEG10_HUMAN, Q05315
Similarity: Contains 1 galectin domain


Find genes that share domains with CLC           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LEG10_HUMAN, Q05315
Function: Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and
suppressive function of CD25-positive regulatory T-cells (Treg)

     Genatlas biochemistry entry for CLC:
Charcot-Leyden crystal protein,eosinophil lysophospholipase,also expressed in basophil,galectin family of
galactoride-beta binding protein

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004622NOT contributes to lysophospholipase activity IDA11834744
GO:0005515protein binding IPI11834744
GO:0030246carbohydrate binding IEA--
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process IDA17502455
     
Find genes that share ontologies with CLC           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for CLC:
 Synthetic lethal with c-Myc af 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLC
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLC

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLC
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLC

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat CLC

Gene Editing
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OriGene clones in human, mouse for CLC (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CLC (NM_001828)
Sino Biological Human cDNA Clone for CLC
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLC

Cell Line
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLC


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LEG10_HUMAN, Q05315: Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be
secreted or transported to other locations in the cell
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol2
lysosome2
nucleus2
vacuole2
mitochondrion1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol IDA17502455

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Arrays including CLC: 
          Growth Factors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Allergy & Asthma in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CLC

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002667regulation of T cell anergy IMP17502455
GO:0002724regulation of T cell cytokine production IMP17502455
GO:0007275multicellular organismal development TAS8400237
GO:0046006regulation of activated T cell proliferation IMP17502455
GO:0070231T cell apoptotic process IDA17502455

Find genes that share ontologies with CLC           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CLC (LEG10)

Selected HMDB Compounds for CLC (see all 1003)    About this table
CompoundSynonyms CAS #PubMed Ids
Arachidic acidArachate (see all 10)506-30-9--
Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
Glycerylphosphorylethanolamine2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)1190-00-7--
Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
LysoPC(0:0/18:0)1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine (see all 4)----
LysoPC(10:0)1-Decanoyllysolecithin (see all 14)22248-63-1--
LysoPC(14:0)LysoPC(14:0) (see all 9)----
LysoPC(14:1(9Z))LysoPC(14:1) (see all 17)----

3 DrugBank Compounds for CLC    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Beta-D-Mannose-- 7322-31-8target--17139284 17016423
N-Ethylmaleimide-- 128-53-0target--17139284 17016423
Para-Mercury-Benzenesulfonic Acid-- --target--17139284 17016423

2 Novoseek inferred chemical compound relationships for CLC gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
chloride 49.1 1 10932070 (1)
mannose 44.7 3 10529229 (2), 11834744 (1)



Find genes that share compounds with CLC           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CLC gene: 
NM_001828.5  

Unigene Cluster for CLC:

Charcot-Leyden crystal protein
Hs.889  [show with all ESTs]
Unigene Representative Sequence: BU199133
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000221804(uc002omh.3)
miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CLC
Predesigned siRNA for gene silencing in human, mouse, rat CLC
Clone
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OriGene clones in human, mouse for CLC (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CLC (NM_001828)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLC
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CLC
OriGene qSTAR qPCR primer pairs in human, mouse for CLC
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CLC
  QuantiTect SYBR Green Assays in human, mouse, rat CLC
  QuantiFast Probe-based Assays in human, mouse, rat CLC

Additional mRNA sequence: 

BC119711.1 BC119712.1 FJ613334.1 FJ613335.1 L01664.1 

3 DOTS entries:

DT.410840  DT.91703965  DT.95364234 

Selected AceView cDNA sequences (see all 56):

NM_001828 AV716973 AV715398 AW292557 AV715261 L01664 AV714984 AV714443 
BU616069 AV717851 BU198323 BU198769 AV715923 BU198603 AV714675 AV757393 
AV715152 AV712928 BU198123 BP431609 R09220 AA040232 AV713515 AV716684 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CLC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATCTTTTCTC
CLC Expression
About this image


CLC expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 7 entries
         Granulocytes Peripheral Blood
         Bone Marrow CD34+ Cells   
         BONE MARROW   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone Marrow
         BONE MARROW   
 
 Liver (Hepatobiliary System)
         Fetal Liver CD34+ Cells   
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
CLC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CLC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.889

UniProtKB/Swiss-Prot: LEG10_HUMAN, Q05315
Tissue specificity: Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils.
Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein
level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the
histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein
level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level)

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CLC: 
          Growth Factors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Allergy & Asthma in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CLC
OriGene qSTAR qPCR primer pairs in human, mouse for CLC
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CLC
QuantiTect SYBR Green Assays in human, mouse, rat CLC
QuantiFast Probe-based Assays in human, mouse, rat CLC
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CLC gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Clc5 Charcot-Leyden crystal protein   --   -


ENSEMBL Gene Tree for CLC (if available)
TreeFam Gene Tree for CLC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CLC gene
LGALS162  LGALS142  LGALS132  
9 SIMAP similar genes for CLC using alignment to 1 protein entry:     LEG10_HUMAN:
LOC400696    LGALS17A    LGALS16    LGALS13    LGALS14    LGALS9C
LGALS9    LGALS9B    LGALS8

Find genes that share paralogs with CLC           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for CLC
PGOHUM00000234687 PGOHUM00000234695


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CLC (see all 266)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1866839171,2
--40221422(+) TGAGGA/GGACGA 1 -- ds50010--------
rs1491751531,2
--40221464(+) TCTTGA/GCATTT 1 -- ds50010--------
rs104077991,2
C,F,H--40221539(+) TGTTCC/TTACTC 1 -- ds500117Minor allele frequency- T:0.08NS EA NA WA CSA 796
rs48020541,2
C,F,A,H--40221564(+) TAAAGA/CGTGAG 1 -- ds500110Minor allele frequency- C:0.41NA WA CSA EA 506
rs772050661,2
F--40221613(+) CCCACC/GCTGTC 1 -- ds50011Minor allele frequency- G:0.12WA 118
rs4401911,2
C,F,A,H--40221643(+) CCCCAG/ATCCCA 1 -- ds500125Minor allele frequency- A:0.37MN NS EA WA NA CSA 2524
rs1159508201,2
F--40221661(+) CACCTC/GAGTGA 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs786050391,2
C,F--40221685(+) GGGTAG/AGGTTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
rs735597141,2
C,F--40221695(+) GGTTCA/GGAGTG 1 -- ds50012Minor allele frequency- G:0.02WA 120
rs1432355661,2
--40221699(+) CAGAGG/TGTCTG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for CLC (40221890 - 40228668 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CLC:    About this table    
Variant IDTypeSubtypePubMed ID
nsv9723CNV Loss18304495
nsv911695CNV Loss21882294
dgv1082e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CLC
DNA2.0 Custom Variant and Variant Library Synthesis for CLC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 153310    OMIM disorders: --

1 disease for CLC:    
About MalaCards
cold-induced sweating syndrome 1

2 diseases from the University of Copenhagen DISEASES database for CLC:
Eosinophilic pneumonia     Eosinophilia

Find genes that share disorders with CLC           About GenesLikeMe

4 Novoseek inferred disease relationships for CLC gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
allergic rhinitis 44.4 3 19650845 (3)
cystic fibrosis 37.3 3 19274342 (1), 9295337 (1)
allergy 25.9 2 16457599 (1)
inflammation 5.96 1 10529229 (1)

Genetic Association Database (GAD): CLC
Human Genome Epidemiology (HuGE) Navigator: CLC (11 documents)

Export disorders for CLC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CLC gene, integrated from 10 sources (see all 51):
(articles sorted by number of sources associating them with CLC)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion. (PubMed id 11834744)1, 2, 3, 9 Ackerman S.J....Acharya K.R. (J. Biol. Chem. 2002)
  2. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PubMed id 1577491)1, 2, 3, 9 Mastrianni D.M.... Ackerman S.J. (Genomics 1992)
  3. Selective recognition of mannose by the human eosinophil Charcot- Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution. (PubMed id 10529229)1, 2, 9 Swaminathan G.J....Acharya K.R. (Biochemistry 1999)
  4. Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. (PubMed id 17502455)1, 2, 9 Kubach J....Jonuleit H. (Blood 2007)
  5. The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes. (PubMed id 9119387)1, 2, 9 Dyer K.D.... Rosenberg H.F. (Genomics 1997)
  6. CLC- a novel susceptibility gene for allergic rhinitis? (PubMed id 19650845)1, 4, 9 Bryborn M....Cardell L.O. (Allergy 2010)
  7. Galectin-10, eosinophils, and celiac disease. (PubMed id 19758173)1, 2, 9 De Re V....Canzonieri V. (Ann. N. Y. Acad. Sci. 2009)
  8. Comparative proteomics of nasal fluid in seasonal allergic rhinitis. (PubMed id 16457599)1, 2, 9 Ghafouri B.... Lindahl M. (J. Proteome Res. 2006)
  9. Galectin-10, a potential biomarker of eosinophilic airway inflammation. (PubMed id 22880030)1, 2 Chua J.C....Meeusen E.N. (PLoS ONE 2012)
  10. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. (PubMed id 19497882)1, 2 Than N.G.... Wildman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1178 HGNC: 2014 AceView: CLC Ensembl:ENSG00000105205 euGenes: HUgn1178
ECgene: CLC H-InvDB: CLC

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CLC Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CLC Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_277

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IP news from LifeMap Sciences, Inc.)
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Patent Information for CLC gene:
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