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CLASRP Gene

protein-coding   GIFtS: 48
GCID: GC19P045545

CLK4-Associating Serine/Arginine Rich Protein

(Previous names: splicing factor, arginine/serine-rich 16)
(Previous symbol: SFRS16)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CLK4-Associating Serine/Arginine Rich Protein1 2     SWAP22 3
SFRS161 2 3     CLASP2
Splicing Factor, Arginine/Serine-Rich 161 3     Splicing Factor, Arginine/Serine-Rich 16 (Suppressor-Of-White-Apricot
Homolog, Drosophila)2
Clk4 Associating SR-Related Protein1 2     Suppressor Of White Apricot Homolog 22
Suppressor Of White-Apricot Homolog 22 3     

External Ids:    HGNC: 177311   Entrez Gene: 111292   Ensembl: ENSG000001048597   UniProtKB: Q8N2M83   

Export aliases for CLASRP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLASRP Gene:
CLASRP (CLK4-associating serine/arginine rich protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: CLASR_HUMAN, Q8N2M8
Function: Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as
CLK1. May act by regulating members of the CLK kinase family (By similarity)

Gene Wiki entry for CLASRP (SFRS16) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CLASRP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLASRP promoter sequence
   Search Chromatin IP Primers for CLASRP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLASRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

CLASRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLASRP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045545:  view genomic region     (about GC identifiers)

Start:
45,542,298 bp from pter      End:
45,574,214 bp from pter
Size:
31,917 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLASR_HUMAN, Q8N2M8 (See protein sequence)
Recommended Name: CLK4-associating serine/arginine rich protein  
Size: 674 amino acids; 77161 Da
Subunit: Probably interacts with CLK4 (By similarity)
Caution: It is uncertain whether Met-1 or Met-16 is the initiator
Sequence caution: Sequence=AAC82339.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC82340.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH80554.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O96026 Q6UW71 Q96DX2
Alternative splicing: 2 isoforms:  Q8N2M8-1   Q8N2M8-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLASRP: NX_Q8N2M8

Explore proteomics data for CLASRP at MOPED

Post-translational modifications: 

  • Phosphorylated in vitro by CLK4 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLASRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265368.1  NP_008987.2  

    ENSEMBL proteins: 
     ENSP00000221455   ENSP00000375815   ENSP00000465750   ENSP00000375814   ENSP00000465562  
     ENSP00000438702   ENSP00000466371   ENSP00000467177  

    CLASRP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CLASRP

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019147 SWAP_N_domain

    Graphical View of Domain Structure for InterPro Entry Q8N2M8

    ProtoNet protein and cluster: Q8N2M8

    UniProtKB/Swiss-Prot: CLASR_HUMAN, Q8N2M8
    Similarity: Belongs to the splicing factor SR family


    Find genes that share domains with CLASRP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLASR_HUMAN, Q8N2M8
    Function: Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as
    CLK1. May act by regulating members of the CLK kinase family (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLASRP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLASRP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLASRP

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLASRP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASRP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLASR_HUMAN, Q8N2M8: Nucleus (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with CLASRP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLASRP About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44


    1 BioSystems Pathway for CLASRP
        mRNA processing


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLASRP
    Interactions:

        Search GeneGlobe Interaction Network for CLASRP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CLASRP (Q8N2M82, 3 ENSP000002214554) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-68015 I2D: score=5 STRING: ENSP00000360441
    ATXN1P542532, 3, ENSP000002447694MINT-2869398 I2D: score=3 STRING: ENSP00000244769
    SMAD3P840223, ENSP000003329734I2D: score=4 STRING: ENSP00000332973
    DYRK1AQ136273, ENSP000003819324I2D: score=1 STRING: ENSP00000381932
    CLK4Q9HAZ13, ENSP000003169484I2D: score=2 STRING: ENSP00000316948
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with CLASRP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLASRP (CLASR)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLASRP gene (2 alternative transcripts): 
    NM_001278439.1  NM_007056.2  

    Unigene Cluster for CLASRP:

    CLK4-associating serine/arginine rich protein
    Hs.466917  [show with all ESTs]
    Unigene Representative Sequence: AK094681
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221455(uc002pak.3 uc010xxh.2 uc002pan.1) ENST00000391953
    ENST00000592056 ENST00000591410 ENST00000391952(uc002pal.3) ENST00000588247
    ENST00000588936 ENST00000544944(uc002pam.3) ENST00000587112 ENST00000588016
    ENST00000585432 ENST00000585615 ENST00000591904 ENST00000587472 ENST00000592876
    ENST00000588070
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLASRP
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      QuantiTect SYBR Green Assays in human, mouse, rat CLASRP
      QuantiFast Probe-based Assays in human, mouse, rat CLASRP

    Additional mRNA sequence: 

    AF042800.1 AK074590.1 AK094681.1 AK293333.1 AL080189.1 BC080554.1 BC131496.1 

    19 DOTS entries:

    DT.95097123  DT.97846179  DT.75103288  DT.445895  DT.91751836  DT.95168394  DT.121504383  DT.99927387 
    DT.212103  DT.100795460  DT.100795461  DT.40132130  DT.92003989  DT.121504384  DT.40310329  DT.91751834 
    DT.121504401  DT.91840275  DT.99950733 

    Selected AceView cDNA sequences (see all 150):

    BF847904 BM694857 CA425870 AI075443 BC080554 AI333255 AF042800 AA873552 
    AW827298 AI937572 AW673444 NM_007056 CB147052 BQ574555 CF529957 BQ710651 
    BI821227 T83122 CR604154 BC013178 AL080189 AW675769 BF914720 BM796472 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLASRP (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                                                    -                                                                                       
    SP2:                                                                                                                                                            
    SP3:              -                                                                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                        -   

    ExUns: 19b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CLASRP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLASRP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAGCGGG
    CLASRP Expression
    About this image


    CLASRP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uterus (Reproductive System)
     
     Spleen (Hematopoietic System)
    CLASRP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLASRP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466917
        Custom PCR Arrays for CLASRP
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASRP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLASRP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clasrp5 CLK4-associating serine/arginine rich protein   --   7 (9.93 cM) 19581044 
    lizard
    (Anolis carolinensis)
    Reptilia CLASRP6
    CLK4-associating serine/arginine rich protein
    85(a)
    1 ↔ 1
    LGf(3413662-3440453)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.162262 Transcribed sequence with weak similarity to protein more 79.05(n)    BG884030.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66956
    --
    29(a)
    1 ↔ 1
    3R(20480884-20485101)
    worm
    (Caenorhabditis elegans)
    Secernentea F28C1.16
    Protein F28C1.1 (F28C1.1) mRNA, complete cds
    29(a)
    1 ↔ 1
    V(12450807-12453811) WBGene00009200


    ENSEMBL Gene Tree for CLASRP (if available)
    TreeFam Gene Tree for CLASRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLASRP (see all 733)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354904
    A breast cancer sample4--see VAR_0354902 L S mis40--------
    rs1455755761,2
    --45541972(+) CGGGCC/TTGGTG 1 -- us2k10--------
    rs1488937171,2
    --45542055(+) GCAGTA/GAGCCT 1 -- us2k10--------
    rs1836340051,2
    --45542070(+) CGCGCC/TACTGC 1 -- us2k10--------
    rs1882966821,2
    --45542130(+) AAATAA/CATAAA 1 -- us2k10--------
    rs1811701581,2
    C--45542178(+) CTTCCC/TTTCTC 1 -- us2k10--------
    rs104049161,2
    C,F,H--45542180(+) TCCCTT/CCTCCG 1 -- us2k1 trp310Minor allele frequency- C:0.02NS NA WA 1106
    rs1864015901,2
    --45542211(+) GATCCC/TGCCCC 1 -- us2k10--------
    rs352562081,2
    C,F--45542277(+) ACCATG/ACTCCG 1 -- us2k12Minor allele frequency- A:0.01NS 94
    rs1917660341,2
    --45542450(+) CATGCC/TGCTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CLASRP (45542298 - 45574214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLASRP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912142CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLASRP
    DNA2.0 Custom Variant and Variant Library Synthesis for CLASRP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLASRP gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with CLASRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. (PubMed id 12169693)1, 3 Katsu R....Hagiwara M. (J. Biol. Chem. 2002)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (Cancer Cell 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11129 HGNC: 17731 AceView: SFRS16 Ensembl:ENSG00000104859 euGenes: HUgn11129
    ECgene: CLASRP H-InvDB: CLASRP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLASRP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLASRP gene:
    Search GeneIP for patents involving CLASRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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