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Aliases for CLASRP Gene

Aliases for CLASRP Gene

  • CLK4 Associating Serine/Arginine Rich Protein 2 3 5
  • CLK4-Associating Serine/Arginine Rich Protein 2 3
  • Splicing Factor, Arginine/Serine-Rich 16 2 4
  • Clk4 Associating SR-Related Protein 2 3
  • SFRS16 3 4
  • SWAP2 3 4
  • Splicing Factor, Arginine/Serine-Rich 16 (Suppressor-Of-White-Apricot Homolog, Drosophila) 3
  • Suppressor Of White Apricot Homolog 2 3
  • Suppressor Of White-Apricot Homolog 2 4
  • CLASP 3

External Ids for CLASRP Gene

Previous HGNC Symbols for CLASRP Gene

  • SFRS16

Previous GeneCards Identifiers for CLASRP Gene

  • GC19P045545

Summaries for CLASRP Gene

GeneCards Summary for CLASRP Gene

CLASRP (CLK4 Associating Serine/Arginine Rich Protein) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for CLASRP Gene

  • Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).

Gene Wiki entry for CLASRP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLASRP Gene

Genomics for CLASRP Gene

Regulatory Elements for CLASRP Gene

Enhancers for CLASRP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045015 1.1 Ensembl ENCODE 13.1 -22.4 -22427 2.6 HDGF WRNIP1 ARID4B BMI1 RAD21 ZNF143 ZNF207 CREM ZNF280D ZNF654 APOC2 CLASRP RNU6-611P ZNF296 GEMIN7 PPP1R37 APOE RELB
GH19F045005 0.7 ENCODE 13 -31.7 -31728 4.3 HDGF ATF1 PKNOX1 ARNT ARID4B SIN3A GLI4 YBX1 GLIS2 ZNF143 APOC2 CLPTM1 CLASRP RNU6-611P GEMIN7 ZNF296 PPP1R37 APOE RELB
GH19F045110 0.7 Ensembl 11.1 +72.2 72161 0.8 HDGF PKNOX1 KLF17 SIN3A ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 KLF7 ZNF296 GEMIN7 CLASRP RELB NKPD1 GC19M045094 PIR57496
GH19F045096 1.2 FANTOM5 Ensembl ENCODE 11.1 +62.4 62358 9.7 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF143 ZNF548 FOS ZNF263 SP3 GEMIN7 ZNF180 ZNF234 FOSB ZNF296 PPP1R37 RELB CCDC61 CLASRP ZNF225
GH19F045231 0.2 ENCODE 10.1 +193.0 193044 1.2 L3MBTL2 MYNN ADNP CKM ERCC2 CD3EAP PPP1R13L RELB CLASRP EXOC3L2 GC19M045188
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CLASRP on UCSC Golden Path with GeneCards custom track

Promoters for CLASRP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044728 60 1401 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 YY1 ZNF302

Genomic Location for CLASRP Gene

Chromosome:
19
Start:
45,039,040 bp from pter
End:
45,070,956 bp from pter
Size:
31,917 bases
Orientation:
Plus strand

Genomic View for CLASRP Gene

Genes around CLASRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLASRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLASRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLASRP Gene

Proteins for CLASRP Gene

  • Protein details for CLASRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2M8-CLASR_HUMAN
    Recommended name:
    CLK4-associating serine/arginine rich protein
    Protein Accession:
    Q8N2M8
    Secondary Accessions:
    • B4DDT8
    • F8WAG9
    • O96026
    • Q6UW71
    • Q96DX2

    Protein attributes for CLASRP Gene

    Size:
    674 amino acids
    Molecular mass:
    77161 Da
    Quaternary structure:
    • Probably interacts with CLK4.
    SequenceCaution:
    • Sequence=AAC82339.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC82340.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH80554.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CLASRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLASRP Gene

Post-translational modifications for CLASRP Gene

No data available for DME Specific Peptides for CLASRP Gene

Domains & Families for CLASRP Gene

Protein Domains for CLASRP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLASRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2M8

UniProtKB/Swiss-Prot:

CLASR_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with CLASRP: view

No data available for Gene Families for CLASRP Gene

Function for CLASRP Gene

Molecular function for CLASRP Gene

UniProtKB/Swiss-Prot Function:
Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).
genes like me logo Genes that share phenotypes with CLASRP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLASRP Gene

Localization for CLASRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLASRP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLASRP Gene COMPARTMENTS Subcellular localization image for CLASRP gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLASRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CLASRP: view

Pathways & Interactions for CLASRP Gene

SuperPathways for CLASRP Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with CLASRP: view

Pathways by source for CLASRP Gene

1 BioSystems pathway for CLASRP Gene

Gene Ontology (GO) - Biological Process for CLASRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with CLASRP: view

No data available for SIGNOR curated interactions for CLASRP Gene

Transcripts for CLASRP Gene

Unigene Clusters for CLASRP Gene

CLK4-associating serine/arginine rich protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLASRP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CLASRP Gene

GeneLoc Exon Structure for
CLASRP
ECgene alternative splicing isoforms for
CLASRP

Expression for CLASRP Gene

mRNA expression in normal human tissues for CLASRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLASRP Gene

This gene is overexpressed in Plasma (26.2), Peripheral blood mononuclear cells (11.2), and Fetal ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLASRP Gene



Protein tissue co-expression partners for CLASRP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLASRP Gene:

CLASRP

SOURCE GeneReport for Unigene cluster for CLASRP Gene:

Hs.466917
genes like me logo Genes that share expression patterns with CLASRP: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLASRP Gene

Orthologs for CLASRP Gene

This gene was present in the common ancestor of animals.

Orthologs for CLASRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLASRP 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLASRP 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clasrp 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLASRP 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLASRP 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLASRP 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii clasrp 35
  • 71 (a)
OneToOne
Dr.16226 34
fruit fly
(Drosophila melanogaster)
Insecta CG6695 35
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F28C1.1 35
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2291 35
  • 37 (a)
OneToOne
Species where no ortholog for CLASRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLASRP Gene

ENSEMBL:
Gene Tree for CLASRP (if available)
TreeFam:
Gene Tree for CLASRP (if available)

Paralogs for CLASRP Gene

No data available for Paralogs for CLASRP Gene

Variants for CLASRP Gene

Sequence variations from dbSNP and Humsavar for CLASRP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035490 A breast cancer sample
rs1009644 -- 45,057,115(-) CCTGC(A/G)CTCAT intron-variant
rs10404916 -- 45,038,922(+) TCCCT(C/T)CTCCG upstream-variant-2KB
rs10405399 -- 45,055,503(+) CCCTT(C/T)TGGCC intron-variant
rs10406578 -- 45,064,291(+) CAGAG(A/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLASRP Gene

Variant ID Type Subtype PubMed ID
esv3583432 CNV loss 25503493
nsv1138710 CNV deletion 24896259
nsv953587 CNV deletion 24416366

Variation tolerance for CLASRP Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLASRP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLASRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLASRP Gene

Disorders for CLASRP Gene

Relevant External Links for CLASRP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLASRP

No disorders were found for CLASRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLASRP Gene

Publications for CLASRP Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. (PMID: 12169693) Katsu R. … Hagiwara M. (J. Biol. Chem. 2002) 2 3 64

Products for CLASRP Gene

Sources for CLASRP Gene

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