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Aliases for CLASRP Gene

Aliases for CLASRP Gene

  • CLK4-Associating Serine/Arginine Rich Protein 2 3
  • Splicing Factor, Arginine/Serine-Rich 16 2 4
  • Suppressor Of White-Apricot Homolog 2 3 4
  • Clk4 Associating SR-Related Protein 2 3
  • SFRS16 3 4
  • SWAP2 3 4
  • Splicing Factor, Arginine/Serine-Rich 16 (Suppressor-Of-White-Apricot Homolog, Drosophila) 3
  • Suppressor Of White Apricot Homolog 2 3
  • CLASP 3

External Ids for CLASRP Gene

Previous Symbols for CLASRP Gene

  • SFRS16

Summaries for CLASRP Gene

GeneCards Summary for CLASRP Gene

CLASRP (CLK4-Associating Serine/Arginine Rich Protein) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for CLASRP Gene

  • Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).

Gene Wiki entry for CLASRP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLASRP Gene

Genomics for CLASRP Gene

Genomic Location for CLASRP Gene

Start:
45,039,040 bp from pter
End:
45,070,956 bp from pter
Size:
31,917 bases
Orientation:
Plus strand

Genomic View for CLASRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLASRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLASRP Gene

No data available for Regulatory Elements for CLASRP Gene

Proteins for CLASRP Gene

  • Protein details for CLASRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2M8-CLASR_HUMAN
    Recommended name:
    CLK4-associating serine/arginine rich protein
    Protein Accession:
    Q8N2M8
    Secondary Accessions:
    • B4DDT8
    • F8WAG9
    • O96026
    • Q6UW71
    • Q96DX2

    Protein attributes for CLASRP Gene

    Size:
    674 amino acids
    Molecular mass:
    77161 Da
    Quaternary structure:
    • Probably interacts with CLK4.
    SequenceCaution:
    • Sequence=AAC82339.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC82340.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH80554.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CLASRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLASRP Gene

Proteomics data for CLASRP Gene at MOPED

Post-translational modifications for CLASRP Gene

No data available for DME Specific Peptides for CLASRP Gene

Domains for CLASRP Gene

Protein Domains for CLASRP Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CLASR_HUMAN
Family:
  • Belongs to the splicing factor SR family.:
    • Q8N2M8
genes like me logo Genes that share domains with CLASRP: view

No data available for Gene Families for CLASRP Gene

Function for CLASRP Gene

Molecular function for CLASRP Gene

UniProtKB/Swiss-Prot Function: Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLASRP Gene

Localization for CLASRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLASRP Gene

Gene Ontology (GO) - Cellular Components for CLASRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CLASRP: view

Pathways for CLASRP Gene

SuperPathways for CLASRP Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with CLASRP: view

Pathways by source for CLASRP Gene

1 BioSystems pathway for CLASRP Gene

Gene Ontology (GO) - Biological Process for CLASRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with CLASRP: view

Transcripts for CLASRP Gene

Unigene Clusters for CLASRP Gene

CLK4-associating serine/arginine rich protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLASRP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CLASRP Gene

GeneLoc Exon Structure for
CLASRP
ECgene alternative splicing isoforms for
CLASRP

Expression for CLASRP Gene

mRNA expression in normal human tissues for CLASRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLASRP Gene

SOURCE GeneReport for Unigene cluster for CLASRP Gene Hs.466917

genes like me logo Genes that share expressions with CLASRP: view

Orthologs for CLASRP Gene

This gene was present in the common ancestor of animals.

Orthologs for CLASRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLASRP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLASRP 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLASRP 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clasrp 16
Clasrp 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLASRP 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLASRP 37
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii clasrp 37
  • 71 (a)
OneToOne
Dr.16226 36
fruit fly
(Drosophila melanogaster)
Insecta CG6695 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F28C1.1 37
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2291 37
  • 37 (a)
OneToOne
Species with no ortholog for CLASRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLASRP Gene

ENSEMBL:
Gene Tree for CLASRP (if available)
TreeFam:
Gene Tree for CLASRP (if available)

Paralogs for CLASRP Gene

No data available for Paralogs for CLASRP Gene

Variants for CLASRP Gene

Sequence variations from dbSNP and Humsavar for CLASRP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1009644 -- 45,057,115(-) CCTGC(A/G)CTCAT intron-variant
rs1063174 -- 45,070,869(+) GGGAG(A/C/G)ACAAG utr-variant-3-prime, nc-transcript-variant
rs1123439 -- 45,053,201(+) GACGT(A/G)GGGTG intron-variant
rs1123440 -- 45,054,030(-) AATTG(C/T)CAAAT intron-variant
rs1560725 -- 45,040,529(-) GGATC(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLASRP Gene

Variant ID Type Subtype PubMed ID
nsv912142 CNV Loss 21882294

Relevant External Links for CLASRP Gene

HapMap Linkage Disequilibrium report
CLASRP

Disorders for CLASRP Gene

No disorders were found for CLASRP Gene.

No data available for UniProtKB/Swiss-Prot for CLASRP Gene

Publications for CLASRP Gene

  1. Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. (PMID: 12169693) Katsu R. … Hagiwara M. (J. Biol. Chem. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CLASRP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CLASRP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CLASRP
    • Block miRNA regulation of CLASRP using miScript Target Protectors

    Sources for CLASRP Gene

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