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CLASP2 Gene

protein-coding   GIFtS: 57
GCID: GC03M033537

Cytoplasmic Linker Associated Protein 2

  Search for CLASP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytoplasmic Linker Associated Protein 21 2     Multiple Asters (Mast)-Like Homolog 22
Cytoplasmic Linker-Associated Protein 22 3     KIAA06273
Protein Orbit Homolog 22 3     hOrbit23
CLIP-Associating Protein 22     

External Ids:    HGNC: 170781   Entrez Gene: 231222   Ensembl: ENSG000001635397   OMIM: 6058535   UniProtKB: O751223   

Export aliases for CLASP2 gene to outside databases

Previous GC identifers: GC03M032843 GC03M033384 GC03M033510 GC03M033509 GC03M033513 GC03M033512


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLASP2 Gene:
CLASP2 (cytoplasmic linker associated protein 2) is a protein-coding gene. GO annotations related to this gene include microtubule plus-end binding and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is CLASP1.

UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122
Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved
in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the
polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May
act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their
plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is
regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing
function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex

Gene Wiki entry for CLASP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLASP2 gene promoter:
         Pax-3   Pbx1a   AML1a   Nkx6-1   ATF-2   FOXO1a   c-Jun   HNF-3beta   YY1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): CLASP2 promoter sequence
   Search Chromatin IP Primers for CLASP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLASP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p24.3

CLASP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLASP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M033537:  view genomic region     (about GC identifiers)

Start:
33,537,737 bp from pter      End:
33,759,848 bp from pter
Size:
222,112 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122 (See protein sequence)
Recommended Name: CLIP-associating protein 2  
Size: 1294 amino acids; 141133 Da
Subunit: Interacts with CLIP2, ERC1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be
mediated by PHLDB2. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends.
Interacts with GCC2; recruits CLASP2 to Golgi membranes. Interacts with MACF1 (By similarity)
Sequence caution: Sequence=BAA31602.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14995.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q7L8F6 Q8N6R6 Q9BQT3 Q9BQT4 Q9H7A3 Q9NSZ2
Alternative splicing: 2 isoforms:  O75122-1   O75122-2   

Explore the universe of human proteins at neXtProt for CLASP2: NX_O75122

Explore proteomics data for CLASP2 at MOPED

Post-translational modifications: 

  • Phosphorylated by GSK3B. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in
    lamella1
  • Ubiquitination2 at Lys671
  • Modification sites at PhosphoSitePlus

  • See CLASP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193973.1  NP_055912.2  

    ENSEMBL proteins: 
     ENSP00000419974   ENSP00000382297   ENSP00000417518   ENSP00000419305   ENSP00000420307  
     ENSP00000418488   ENSP00000417386   ENSP00000417666   ENSP00000324364   ENSP00000418939  
     ENSP00000327760   ENSP00000418945   ENSP00000418411   ENSP00000352581   ENSP00000304743  
     ENSP00000439039  
    Reactome Protein details: O75122

    CLASP2 Human Recombinant Protein Products:

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    Novus Biologicals CLASP2 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CLASP2

     
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    CLASP2 Assay Products:

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    Cloud-Clone Corp. ELISAs for CLASP2
    Cloud-Clone Corp. CLIAs for CLASP2
    Search eBioscience for ELISAs for CLASP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR028399 CLASP_metazoan
     IPR024395 CLASP_N_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O75122

    ProtoNet protein and cluster: O75122

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122
    Domain: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to
    the growing microtubule plus ends
    Similarity: Belongs to the CLASP family
    Similarity: Contains 5 HEAT repeats


    Find genes that share domains with CLASP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLAP2_HUMAN, O75122
    Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved
    in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the
    polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May
    act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their
    plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is
    regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing
    function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
    Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI11290329
    GO:0008017microtubule binding ----
    GO:0008107galactoside 2-alpha-L-fucosyltransferase activity NAS11290329
    GO:0043515kinetochore binding ----
         
    Find genes that share ontologies with CLASP2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Clasp2):
     cellular 

    Find genes that share phenotypes with CLASP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Clasp2tm1Gal for CLASP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLASP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLASP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLASP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLASP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLASP2:
    hsa-mir-210-3p (MIRT003180)

    Block miRNA regulation of human, mouse, rat CLASP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLASP2 (see all 86):
    hsa-miR-200a hsa-miR-502-3p hsa-miR-3613-3p hsa-miR-200b hsa-miR-130a* hsa-miR-409-3p hsa-miR-3065-5p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCLASP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLASP2
    Predesigned siRNA for gene silencing in human, mouse, rat CLASP2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CLASP2 (NM_015097)
    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for CLASP2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLAP2_HUMAN, O75122: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus,
    trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Note=Localizes to microtubule plus ends.
    Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the
    spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of
    microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell
    cortex and this requires ERC1 and PHLDB2. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the
    phosophorylated form to the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    plasma membrane5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005737cytoplasm NAS11290329
    GO:0005794Golgi apparatus IDA11290329
    GO:0005802trans-Golgi network IDA17543864
    GO:0005815microtubule organizing center IEA--

    Find genes that share ontologies with CLASP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLASP2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Signaling by Robo receptor
    Signaling by Robo receptor
    Role of Abl in Robo-Slit signaling0.00


    Find genes that share SuperPaths with CLASP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CLASP2
        Signaling by Slit

    4 Reactome Pathways for CLASP2
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Role of Abl in Robo-Slit signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including CLASP2: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLASP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLASP2 (O751221, 2, 3 ENSP000003525814) via UniProtKB, MINT, STRING, and/or I2D (see all 208)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP9Q999962, 3, ENSP000003485734MINT-7263710 I2D: score=1 STRING: ENSP00000348573
    CLIP2Q9UDT63, ENSP000002233984I2D: score=3 STRING: ENSP00000223398
    FEZ1Q996893, ENSP000002789194I2D: score=2 STRING: ENSP00000278919
    MACF1Q9UPN33, ENSP000002898934I2D: score=1 STRING: ENSP00000289893
    MAPRE1Q156913, ENSP000003647214I2D: score=1 STRING: ENSP00000364721
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007020microtubule nucleation IMP17543864
    GO:0007026negative regulation of microtubule depolymerization NAS11290329
    GO:0007067mitosis IEA--
    GO:0007163establishment or maintenance of cell polarity TAS15928712

    Find genes that share ontologies with CLASP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLASP2 (CLAP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLASP2 gene (2 alternative transcripts): 
    NM_001207044.1  NM_015097.2  

    Unigene Cluster for CLASP2:

    Cytoplasmic linker associated protein 2
    Hs.108614  [show with all ESTs]
    Unigene Representative Sequence: NM_015097
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000464961 ENST00000468888(uc003cfs.3 uc021wva.1 uc021wvb.1)
    ENST00000399362(uc021wvc.1) ENST00000480013 ENST00000461133 ENST00000487553
    ENST00000476251 ENST00000494261 ENST00000480385 ENST00000493577 ENST00000491045
    ENST00000475576 ENST00000313350(uc003cfv.3) ENST00000487200(uc003cfw.2)
    ENST00000333778(uc011axu.1) ENST00000485378 ENST00000496954 ENST00000476433

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLASP2 (see all 86):
    hsa-miR-200a hsa-miR-502-3p hsa-miR-3613-3p hsa-miR-200b hsa-miR-130a* hsa-miR-409-3p hsa-miR-3065-5p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCLASP2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CLASP2 (NM_015097)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLASP2
    Addgene plasmids for CLASP2 
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    Additional mRNA sequence: 

    AB014527.2 AJ288058.1 AJ288059.1 AK024770.1 AK090716.1 AK091451.1 AK293963.1 AK294345.1 
    AK297322.1 AL137636.1 BC011530.1 BC029035.1 BC140778.1 BX640725.1 CR626991.1 DQ200869.1 

    Selected DOTS entries (see all 29):

    DT.100678042  DT.120857153  DT.449715  DT.92065443  DT.95086269  DT.120857057  DT.97770984  DT.100729790 
    DT.100025105  DT.120857058  DT.120857037  DT.422447  DT.100789651  DT.91757364  DT.120857133  DT.99967299 
    DT.100656905  DT.120857106  DT.95239363  DT.100789648  DT.102833813  DT.120857046  DT.120857047  DT.120857075 

    Selected AceView cDNA sequences (see all 154):

    BM683141 AI867327 BC011530 AI741784 AA932790 BX640725 AJ288059 AX746992 
    BF057442 Z44358 BE467690 AW445014 AA447599 AB014527 AK091451 AK096899 
    AL137636 AA358284 Z42167 Z38426 BF591067 AI797401 BX641668 AJ288058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLASP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTTCTAT
    CLASP2 Expression
    About this image


    CLASP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    CLASP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLASP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.108614

    UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122
    Tissue specificity: Brain-specific

        Pathway & Disease-focused RT2 Profiler PCR Array including CLASP2: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLASP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clasp21 , 5 CLIP associating protein 21, 5 89.56(n)1
    94.98(a)1
      9 (64.06 cM)5
    764991  NM_001114347.11  NP_001107819.11 
     1138125865 
    chicken
    (Gallus gallus)
    Aves CLASP21 cytoplasmic linker associated protein 2 81.22(n)
    87.62(a)
      420724  NM_001177385.1  NP_001170856.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLASP26
    cytoplasmic linker associated protein 2
    83(a)
    1 ↔ 1
    GL343324.1(912764-1002116)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147602 Transcribed sequence with moderate similarity to protein more 77.07(n)    BM070795.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chb6
    chromosome bows
    29(a)
    1 → many
    3L(21165953-21176378)
    worm
    (Caenorhabditis elegans)
    Secernentea cls-21 cls-2 44.23(n)
    31.38(a)
      176280  NM_066604.3  NP_499005.2 


    ENSEMBL Gene Tree for CLASP2 (if available)
    TreeFam Gene Tree for CLASP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLASP2 gene
    CLASP12  
    3 SIMAP similar genes for CLASP2 using alignment to 17 protein entries:     CLAP2_HUMAN (see all proteins):
    DKFZp686D11262    DKFZp686D1968    CLASP1

    Find genes that share paralogs with CLASP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CLASP2
    PGOHUM00000235757


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLASP2 (see all 3825)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105768521,2
    C--33488296(+) gtctc-/G/GAA 
     A
    /GAAAA
    aaaaa
    2 -- int11NA 2
    rs1123898661,2
    C,F--33537240(+) TGCCCG/ACCTCG 2 -- int12Minor allele frequency- A:0.50NA WA 4
    rs784578891,2
    C--33537270(+) TTACAG/TGTGTG 2 -- int10--------
    rs1997062571,2
    --33537295(+) GCCTT-/TCTCTTT 2 -- int10--------
    rs2009027211,2
    C--33537297(+) CTTTC-/TCTT  
            
    TTTTT
    2 -- int10--------
    rs1158367101,2
    F--33537318(+) ACAACG/AGAATT 2 -- int12Minor allele frequency- A:0.02WA NA 238
    rs1386252311,2
    --33537319(+) CAACGA/GAATTC 2 -- int10--------
    rs1165827901,2
    C,F--33537457(+) CATTTC/TTATTT 2 -- int11Minor allele frequency- T:0.01NA 120
    rs46790341,2
    C,F,A,H--33537513(+) TTAACA/CAATAG 2 -- int18Minor allele frequency- C:0.05NS EA NA 666
    rs46790351,2
    C,F,A,H--33537713(+) GATTTT/AGAAAC 2 -- int17Minor allele frequency- A:0.05NS EA NA 660

    HapMap Linkage Disequilibrium report for CLASP2 (33537737 - 33759848 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CLASP2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5412CNV Deletion18987735
    esv2725122CNV Deletion23290073
    esv2725121CNV Deletion23290073
    esv2659678CNV Deletion23128226
    nsv3756CNV Insertion18451855
    nsv3754CNV Loss18451855
    nsv236645CNV Loss16902084
    esv6458CNV Loss19470904
    nsv876681CNV Loss21882294
    nsv525628CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLASP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CLASP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605853    OMIM disorders: --


    Find genes that share disorders with CLASP2           About GenesLikeMe

    Genetic Association Database (GAD): CLASP2
    Human Genome Epidemiology (HuGE) Navigator: CLASP2 (2 documents)

    Export disorders for CLASP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLASP2 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with CLASP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. (PubMed id 20219685)1, 4 Inkster B....Matthews P.M. (Neuroimage 2010)
    4. An EB1-binding motif acts as a microtubule tip localization signal. (PubMed id 19632184)1, 2 Honnappa S.... Steinmetz M.O. (Cell 2009)
    5. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. (PubMed id 17543864)1, 2 Efimov A.... Kaverina I. (Dev. Cell 2007)
    6. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. (PubMed id 16866869)1, 2 Mimori-Kiyosue Y.... Vorobjev I. (Genes Cells 2006)
    7. CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. (PubMed id 16824950)1, 2 Lansbergen G....Akhmanova A. (Dev. Cell 2006)
    8. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. (PubMed id 16914514)1, 2 Pereira A.L.... Maiato H. (Mol. Biol. Cell 2006)
    9. Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. (PubMed id 15955847)1, 2 Wittmann T. and Waterman-Storer C.M. (J. Cell Biol. 2005)
    10. CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. (PubMed id 15631994)1, 2 Mimori-Kiyosue Y....Akhmanova A. (J. Cell Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23122 HGNC: 17078 AceView: CLASP2 Ensembl:ENSG00000163539 euGenes: HUgn23122
    ECgene: CLASP2 H-InvDB: CLASP2

    (According to HUGE)
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    HUGE: KIAA0627

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLASP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLASP2 gene:
    Search GeneIP for patents involving CLASP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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