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Aliases for CLASP2 Gene

Aliases for CLASP2 Gene

  • Cytoplasmic Linker Associated Protein 2 2 3
  • Cytoplasmic Linker-Associated Protein 2 4
  • Protein Orbit Homolog 2 4
  • KIAA0627 4
  • HOrbit2 4

External Ids for CLASP2 Gene

Summaries for CLASP2 Gene

GeneCards Summary for CLASP2 Gene

CLASP2 (Cytoplasmic Linker Associated Protein 2) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule plus-end binding and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is CLASP1.

UniProtKB/Swiss-Prot for CLASP2 Gene

  • Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Gene Wiki entry for CLASP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLASP2 Gene

Genomics for CLASP2 Gene

Genomic Location for CLASP2 Gene

Start:
33,496,245 bp from pter
End:
33,718,356 bp from pter
Size:
222,112 bases
Orientation:
Minus strand

Genomic View for CLASP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLASP2 Gene

Regulatory Elements for CLASP2 Gene

Proteins for CLASP2 Gene

  • Protein details for CLASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75122-CLAP2_HUMAN
    Recommended name:
    CLIP-associating protein 2
    Protein Accession:
    O75122
    Secondary Accessions:
    • B2RTR1
    • F5H604
    • Q7L8F6
    • Q8N6R6
    • Q9BQT3
    • Q9BQT4
    • Q9H7A3
    • Q9NSZ2

    Protein attributes for CLASP2 Gene

    Size:
    1294 amino acids
    Molecular mass:
    141133 Da
    Quaternary structure:
    • Interacts with CLIP2, ERC1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with GCC2; recruits CLASP2 to Golgi membranes. Interacts with MACF1 (By similarity).
    SequenceCaution:
    • Sequence=BAA31602.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CLASP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLASP2 Gene

Proteomics data for CLASP2 Gene at MOPED

Post-translational modifications for CLASP2 Gene

  • Phosphorylated by GSK3B. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys671

No data available for DME Specific Peptides for CLASP2 Gene

Domains for CLASP2 Gene

Protein Domains for CLASP2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CLAP2_HUMAN
Domain:
  • The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.:
    • O75122
Family:
  • Belongs to the CLASP family.:
    • O75122
Similarity:
  • Contains 5 HEAT repeats.:
    • O75122
genes like me logo Genes that share domains with CLASP2: view

No data available for Gene Families for CLASP2 Gene

Function for CLASP2 Gene

Molecular function for CLASP2 Gene

UniProtKB/Swiss-Prot Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Gene Ontology (GO) - Molecular Function for CLASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 11290329
GO:0008017 microtubule binding --
GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity NAS 11290329
GO:0051010 microtubule plus-end binding IDA 11290329
genes like me logo Genes that share ontologies with CLASP2: view

Phenotypes for CLASP2 Gene

MGI mutant phenotypes for CLASP2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CLASP2: view

Animal Models for CLASP2 Gene

MGI Knock Outs for CLASP2:

miRNA for CLASP2 Gene

miRTarBase miRNAs that target CLASP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLASP2 Gene

Localization for CLASP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLASP2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLASP2 Gene COMPARTMENTS Subcellular localization image for CLASP2 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CLASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005737 cytoplasm NAS 11290329
GO:0005794 Golgi apparatus IDA 11290329
GO:0005802 trans-Golgi network IDA 17543864
genes like me logo Genes that share ontologies with CLASP2: view

Pathways for CLASP2 Gene

genes like me logo Genes that share pathways with CLASP2: view

Pathways by source for CLASP2 Gene

1 Qiagen pathway for CLASP2 Gene

Gene Ontology (GO) - Biological Process for CLASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007020 microtubule nucleation IMP 17543864
GO:0007026 negative regulation of microtubule depolymerization NAS 11290329
GO:0007067 mitotic nuclear division IEA --
GO:0007163 establishment or maintenance of cell polarity TAS 15928712
genes like me logo Genes that share ontologies with CLASP2: view

Transcripts for CLASP2 Gene

Unigene Clusters for CLASP2 Gene

Cytoplasmic linker associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLASP2 Gene

No ASD Table

Relevant External Links for CLASP2 Gene

GeneLoc Exon Structure for
CLASP2
ECgene alternative splicing isoforms for
CLASP2

Expression for CLASP2 Gene

mRNA expression in normal human tissues for CLASP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLASP2 Gene

SOURCE GeneReport for Unigene cluster for CLASP2 Gene Hs.108614

mRNA Expression by UniProt/SwissProt for CLASP2 Gene

O75122-CLAP2_HUMAN
Tissue specificity: Brain-specific
genes like me logo Genes that share expressions with CLASP2: view

Orthologs for CLASP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLASP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLASP2 36
  • 99.4 (n)
  • 99.13 (a)
CLASP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLASP2 36
  • 94.17 (n)
  • 98.28 (a)
CLASP2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLASP2 36
  • 95.21 (n)
  • 97.86 (a)
CLASP2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clasp2 36
  • 89.56 (n)
  • 94.98 (a)
Clasp2 16
Clasp2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLASP2 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLASP2 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clasp2 36
  • 90.25 (n)
  • 97.26 (a)
chicken
(Gallus gallus)
Aves CLASP2 36
  • 81.22 (n)
  • 87.62 (a)
CLASP2 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLASP2 37
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii clasp2 36
  • 68.59 (n)
  • 80.54 (a)
clasp2 37
  • 73 (a)
OneToOne
Dr.14760 36
fruit fly
(Drosophila melanogaster)
Insecta chb 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cls-1 37
  • 21 (a)
ManyToMany
cls-2 36
  • 44.23 (n)
  • 31.38 (a)
cls-2 37
  • 25 (a)
ManyToMany
cls-3 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12093 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3398 37
  • 41 (a)
OneToMany
Species with no ortholog for CLASP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLASP2 Gene

ENSEMBL:
Gene Tree for CLASP2 (if available)
TreeFam:
Gene Tree for CLASP2 (if available)

Paralogs for CLASP2 Gene

Paralogs for CLASP2 Gene

Pseudogenes.org Pseudogenes for CLASP2 Gene

genes like me logo Genes that share paralogs with CLASP2: view

Variants for CLASP2 Gene

Sequence variations from dbSNP and Humsavar for CLASP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10764 -- 33,496,538(-) TTTAA(C/T)GTGTC utr-variant-3-prime
rs13954 -- 33,498,401(-) ATCAA(C/T)TGATC utr-variant-3-prime
rs492736 -- 33,512,721(-) gagcc(A/C)cccct intron-variant
rs492851 -- 33,512,684(-) tCCAG(G/T)GTATG intron-variant
rs499109 -- 33,500,493(-) GGCTA(C/G)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLASP2 Gene

Variant ID Type Subtype PubMed ID
nsv460487 CNV Gain 19166990
esv2725121 CNV Deletion 23290073
esv2725122 CNV Deletion 23290073
esv5412 CNV Deletion 18987735
esv2659678 CNV Deletion 23128226
nsv236645 CNV Loss 16902084
esv6458 CNV Loss 19470904
nsv525628 CNV Loss 19592680
nsv3754 CNV Loss 18451855
nsv876681 CNV Loss 21882294
nsv3756 CNV Insertion 18451855
esv259476 OTHER Complex 20981092
nsv522881 CNV Gain 19592680

Relevant External Links for CLASP2 Gene

HapMap Linkage Disequilibrium report
CLASP2
Human Gene Mutation Database (HGMD)
CLASP2

Disorders for CLASP2 Gene

Relevant External Links for CLASP2

Genetic Association Database (GAD)
CLASP2
Human Genome Epidemiology (HuGE) Navigator
CLASP2
genes like me logo Genes that share disorders with CLASP2: view

No data available for UniProtKB/Swiss-Prot for CLASP2 Gene

Publications for CLASP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization. (PMID: 10899121) Lemos C.L. … Sunkel C.E. (EMBO J. 2000) 2 3
  3. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. (PMID: 11290329) Akhmanova A. … Galjart N. (Cell 2001) 3 4
  4. GSK3beta phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment. (PMID: 19289791) Kumar P. … Wittmann T. (J. Cell Biol. 2009) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CLASP2 Gene

Sources for CLASP2 Gene

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