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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLASP2 Gene

protein-coding   GIFtS: 57
GCID: GC03M033537

Cytoplasmic Linker Associated Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytoplasmic Linker Associated Protein 21 2     Multiple Asters (Mast)-Like Homolog 22
Cytoplasmic Linker-Associated Protein 22 3     KIAA06273
Protein Orbit Homolog 22 3     hOrbit23
CLIP-Associating Protein 22     

External Ids:    HGNC: 170781   Entrez Gene: 231222   Ensembl: ENSG000001635397   OMIM: 6058535   UniProtKB: O751223   

Export aliases for CLASP2 gene to outside databases

Previous GC identifers: GC03M032843 GC03M033384 GC03M033510 GC03M033509 GC03M033513 GC03M033512


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CLASP2 Gene: 
CLASP2 (cytoplasmic linker associated protein 2) is a protein-coding gene. Diseases associated with CLASP2 include neuroblastoma, and neuronitis, and among its related super-pathways are Mitotic Anaphase and Signaling by Robo receptor. GO annotations related to this gene include microtubule plus-end binding and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is CLASP1.

UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122
Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved
in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the
polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May
act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their
plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is
regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing
function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex

Gene Wiki entry for CLASP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLASP2 gene promoter:
         Pax-3   Pbx1a   AML1a   Nkx6-1   ATF-2   FOXO1a   c-Jun   HNF-3beta   YY1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): CLASP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLASP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLASP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p24.3

CLASP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLASP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M033537:  view genomic region     (about GC identifiers)

Start:
33,537,737 bp from pter      End:
33,759,848 bp from pter
Size:
222,112 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122 (See protein sequence)
Recommended Name: CLIP-associating protein 2  
Size: 1294 amino acids; 141133 Da
Subunit: Interacts with CLIP2, ERC1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be
mediated by PHLDB2. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends.
Interacts with GCC2; recruits CLASP2 to Golgi membranes. Interacts with MACF1 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus,
trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Note=Localizes to microtubule plus ends.
Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the
spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of
microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell
cortex and this requires ERC1 and PHLDB2. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the
phosophorylated form to the cell membrane
Sequence caution: Sequence=BAA31602.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14995.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q7L8F6 Q8N6R6 Q9BQT3 Q9BQT4 Q9H7A3 Q9NSZ2
Alternative splicing: 2 isoforms:  O75122-1   O75122-2   

Explore the universe of human proteins at neXtProt for CLASP2: NX_O75122

Explore proteomics data for CLASP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by GSK3B. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in
    lamella
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75122

  • CLASP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLASP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001193973.1  NP_055912.2  

    ENSEMBL proteins: 
     ENSP00000419974   ENSP00000382297   ENSP00000417518   ENSP00000419305   ENSP00000420307  
     ENSP00000418488   ENSP00000417386   ENSP00000417666   ENSP00000324364   ENSP00000418939  
     ENSP00000327760   ENSP00000418945   ENSP00000418411   ENSP00000352581   ENSP00000304743  
     ENSP00000439039  
    Reactome Protein details: O75122
    Human Recombinant Protein Products for CLASP2: 
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    Novus Biologicals CLASP2 Protein
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    Cloud-Clone Corp. Proteins for CLASP2 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005737cytoplasm NAS11290329
    GO:0005794Golgi apparatus IDA11290329
    GO:0005802trans-Golgi network IDA17543864
    GO:0005815microtubule organizing center IEA--

    CLASP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR024395 CLASP_N_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O75122

    ProtoNet protein and cluster: O75122

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122
    Domain: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to
    the growing microtubule plus ends
    Similarity: Belongs to the CLASP family
    Similarity: Contains 5 HEAT repeats


    CLASP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLAP2_HUMAN, O75122
    Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved
    in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the
    polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May
    act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their
    plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is
    regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing
    function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
    Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI11290329
    GO:0008017microtubule binding ----
    GO:0008107galactoside 2-alpha-L-fucosyltransferase activity NAS11290329
    GO:0051010microtubule plus-end binding IDA11290329
         
    CLASP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Clasp2):
     cellular 

    CLASP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clasp2tm1Gal for CLASP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLASP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLASP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLASP2 
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    hsa-mir-210 (MIRT003180)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLASP2
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate CLASP2 (see all 86):
    hsa-miR-200a hsa-miR-502-3p hsa-miR-3613-3p hsa-miR-200b hsa-miR-130a* hsa-miR-409-3p hsa-miR-3065-5p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCLASP2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLASP2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Developmental Biology
    Signaling by Robo receptor1.00
    Developmental Biology1.00
    Axon guidance1.00
    Role of Abl in Robo-Slit signaling1.00
    3Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Axon guidance
    Axon guidance0.69
    Developmental Biology0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CLASP2
        Signaling by Slit

    5/17        Reactome Pathways for CLASP2 (see all 17)
        Developmental Biology
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Cell Cycle
    M Phase



    CLASP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLASP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/140 Interacting proteins for CLASP2 (O751221, 2, 3 ENSP000003525814) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP9Q999962, 3, ENSP000003485734MINT-7263710 I2D: score=1 STRING: ENSP00000348573
    CLIP1P306223, ENSP000003516654I2D: score=2 STRING: ENSP00000351665
    FEZ1Q996893, ENSP000002789194I2D: score=2 STRING: ENSP00000278919
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    MACF1Q9UPN33, ENSP000002898934I2D: score=1 STRING: ENSP00000289893
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007020microtubule nucleation IMP17543864
    GO:0007026negative regulation of microtubule depolymerization NAS11290329
    GO:0007067mitosis IEA--
    GO:0007163establishment or maintenance of cell polarity TAS15928712

    CLASP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLASP2 (CLAP2)

    Search CenterWatch for drugs/clinical trials and news about CLASP2 / CLAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLASP2 gene (2 alternative transcripts): 
    NM_001207044.1  NM_015097.2  

    Unigene Cluster for CLASP2:

    Cytoplasmic linker associated protein 2
    Hs.108614  [show with all ESTs]
    Unigene Representative Sequence: NM_015097
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000464961 ENST00000468888(uc003cfs.3 uc021wva.1 uc021wvb.1)
    ENST00000399362(uc021wvc.1) ENST00000480013 ENST00000461133 ENST00000487553
    ENST00000476251 ENST00000494261 ENST00000480385 ENST00000493577 ENST00000491045
    ENST00000475576 ENST00000313350(uc003cfv.3) ENST00000487200(uc003cfw.2)
    ENST00000333778(uc011axu.1) ENST00000485378 ENST00000496954 ENST00000476433

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    hsa-miR-200a hsa-miR-502-3p hsa-miR-3613-3p hsa-miR-200b hsa-miR-130a* hsa-miR-409-3p hsa-miR-3065-5p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCLASP2 3' UTR sequence
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    Additional mRNA sequence: 

    AB014527.2 AJ288058.1 AJ288059.1 AK024770.1 AK090716.1 AK091451.1 AK293963.1 AK294345.1 
    AK297322.1 AL137636.1 BC011530.1 BC029035.1 BC140778.1 BX640725.1 CR626991.1 DQ200869.1 

    24/29 DOTS entries (see all 29):

    DT.100678042  DT.120857153  DT.449715  DT.92065443  DT.95086269  DT.120857057  DT.97770984  DT.100729790 
    DT.100025105  DT.120857058  DT.120857037  DT.422447  DT.100789651  DT.91757364  DT.120857133  DT.99967299 
    DT.100656905  DT.120857106  DT.95239363  DT.100789648  DT.102833813  DT.120857046  DT.120857047  DT.120857075 

    24/154 AceView cDNA sequences (see all 154):

    AA587608 AW445014 Z42167 BX641668 AA682989 AI445642 AW207044 BM661506 
    AA122225 BF591067 BC011530 AJ288058 CR626991 AL137636 BM683141 BU179571 
    BC029035 AW452787 AX746588 BM719186 AI741784 AB014527 BX640725 AK091451 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLASP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTTCTAT
    CLASP2 Expression
    About this image


    See CLASP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLASP2

    SOURCE GeneReport for Unigene cluster: Hs.108614

    UniProtKB/Swiss-Prot: CLAP2_HUMAN, O75122
    Tissue specificity: Brain-specific

        SABiosciences Expression via Pathway-Focused PCR Array including CLASP2: 
              Cytoskeleton Regulators in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CLASP2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clasp21 , 5 CLIP associating protein 21, 5 89.56(n)1
    94.98(a)1
      9 (64.06 cM)5
    764991  NM_001114347.11  NP_001107819.11 
     1138125865 
    chicken
    (Gallus gallus)
    Aves CLASP21 cytoplasmic linker associated protein 2 81.22(n)
    87.62(a)
      420724  NM_001177385.1  NP_001170856.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLASP26
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343324.1(912764-1002116)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147602 Transcribed sequence with moderate similarity to protein more 77.07(n)    BM070795.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chb6
    chromosome bows
    27(a)
    1 → many
    3L(21165953-21176378)
    worm
    (Caenorhabditis elegans)
    Secernentea cls-36
    cls-26
    (see all 3)
    Protein CLASP-2
    (see all 3)
    24(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9186556-9191109)
    III(9055052-9058882)


    ENSEMBL Gene Tree for CLASP2 (if available)
    TreeFam Gene Tree for CLASP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLASP2 gene
    CLASP12  
    3 SIMAP similar genes for CLASP2 using alignment to 17 protein entries:     CLAP2_HUMAN (see all proteins):
    DKFZp686D11262    DKFZp686D1968    CLASP1

    CLASP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLASP2
    PGOHUM00000235757


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3825 SNPs in CLASP2 are shown (see all 3825)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105768521,2
    C--33488296(+) gtctc-/G/GAA 
     A
    /GAAAA
    aaaaa
    2 -- int11NA 2
    rs1123898661,2
    C,F--33537240(+) TGCCCG/ACCTCG 2 -- int12Minor allele frequency- A:0.50NA WA 4
    rs784578891,2
    C--33537270(+) TTACAG/TGTGTG 2 -- int10--------
    rs1997062571,2
    --33537295(+) GCCTT-/TCTCTTT 2 -- int10--------
    rs2009027211,2
    C--33537297(+) CTTTC-/TCTT  
            
    TTTTT
    2 -- int10--------
    rs1158367101,2
    F--33537318(+) ACAACG/AGAATT 2 -- int12Minor allele frequency- A:0.02WA NA 238
    rs1386252311,2
    --33537319(+) CAACGA/GAATTC 2 -- int10--------
    rs1165827901,2
    C,F--33537457(+) CATTTC/TTATTT 2 -- int11Minor allele frequency- T:0.01NA 120
    rs46790341,2
    C,F,A,H--33537513(+) TTAACA/CAATAG 2 -- int18Minor allele frequency- C:0.05NS EA NA 666
    rs46790351,2
    C,F,A,H--33537713(+) GATTTT/AGAAAC 2 -- int17Minor allele frequency- A:0.05NS EA NA 660

    HapMap Linkage Disequilibrium report for CLASP2 (33537737 - 33759848 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CLASP2 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv5412CNV Deletion18987735
    esv2725122CNV Deletion23290073
    esv2725121CNV Deletion23290073
    esv2659678CNV Deletion23128226
    nsv3756CNV Insertion18451855
    nsv3754CNV Loss18451855
    nsv236645CNV Loss16902084
    esv6458CNV Loss19470904
    nsv876681CNV Loss21882294
    nsv525628CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605853    OMIM disorders: --

    2 diseases for CLASP2:    About MalaCards
    neuroblastoma    neuronitis


    CLASP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLASP2
    Human Genome Epidemiology (HuGE) Navigator: CLASP2 (2 documents)

    Export disorders for CLASP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLASP2 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with CLASP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Pathway-based approaches to imaging genetics associat ion studies: Wnt signaling, GSK3beta substrates and major depression. (PubMed id 20219685)1, 4 Inkster B....Matthews P.M. (2010)
    4. An EB1-binding motif acts as a microtubule tip locali zation signal. (PubMed id 19632184)1, 2 Honnappa S....Steinmetz M.O. (2009)
    5. Asymmetric CLASP-dependent nucleation of noncentrosom al microtubules at the trans-Golgi network. (PubMed id 17543864)1, 2 Efimov A....Kaverina I. (2007)
    6. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. (PubMed id 16866869)1, 2 Mimori-Kiyosue Y.... Vorobjev I. (2006)
    7. CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. (PubMed id 16824950)1, 2 Lansbergen G....Akhmanova A. (2006)
    8. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. (PubMed id 16914514)1, 2 Pereira A.L.... Maiato H. (2006)
    9. Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. (PubMed id 15955847)1, 2 Wittmann T. and Waterman-Storer C.M. (2005)
    10. CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. (PubMed id 15631994)1, 2 Mimori-Kiyosue Y....Akhmanova A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23122 HGNC: 17078 AceView: CLASP2 Ensembl:ENSG00000163539 euGenes: HUgn23122
    ECgene: CLASP2 H-InvDB: CLASP2

    (According to HUGE)
    About This Section
    HUGE: KIAA0627

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLASP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLASP2 gene:
    Search GeneIP for patents involving CLASP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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