CLASP1 Gene
protein-coding GIFtS: 61
GCID: GC02M122095
|
|
cytoplasmic linker associated protein 1
| |
Aliases
for CLASP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytoplasmic Linker Associated Protein 11 2 | | Protein Orbit Homolog 12 3 | | MAST11 2 3 | | CLIP-Associating Protein 12 | | KIAA06221 3 5 | | Multiple Asters 12 | | Cytoplasmic Linker-Associated Protein 12 3 | | HOrbit11 | | Multiple Asters Homolog 12 3 | | |
Export aliases for CLASP1 gene to outside databasesPrevious GC identifers: GC02M119300 GC02M120015 GC02M122002 GC02M122190 GC02M121811 GC02M114418 |
Summaries
for CLASP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLASP1:
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle(Maiato et al., 2003 (PubMed 12837247)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CLAP1_HUMAN, Q7Z460Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved inthe nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for thepolarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act atthe cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends tocortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at leastin part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochorewhich is essential for the bipolar alignment of chromosomes on the mitotic spindle
Gene Wiki entry for CLASP1
|
Genomic Views
for CLASP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLASP1 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a aMEF-2 POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLASP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLASP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.2-q14.3 Ensembl cytogenetic band: 2q14.3 HGNC cytogenetic band: 2q14.2-q14.3CLASP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M122095: view genomic region
(about GC identifiers)
Start:
|
122,095,352 bp from pter |
End:
|
122,407,163 bp from pter |
Size:
|
311,812 bases |
Orientation:
|
minus strand |
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Proteins
for CLASP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLAP1_HUMAN, Q7Z460 (See
protein sequence)Recommended Name: CLIP-associating protein 1 Size: 1538 amino acids; 169451 Da
Subunit: Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may bemediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes. Interacts with MACF1 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere,kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network (Probable). Note=Localizes tomicrotubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequentlylocalizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to theplus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes tothe cell cortex and this requires ERC1 and PHLDB2
Sequence caution: Sequence=AAH32563.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAX88872.1; Type=Erroneous gene model prediction;
Secondary accessions: O75118 Q2KHQ9 Q5H9P0 Q8N5B8 Q9BQT5Alternative splicing: 3 isoforms: Q7Z460-1 Q7Z460-2 Q7Z460-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CLASP1: NX_Q7Z460
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z460
CLASP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001135745.1 NP_001135746.1 NP_001193980.1 NP_056097.1
ENSEMBL proteins: ENSP00000386442 ENSP00000400562 ENSP00000447929 ENSP00000392886 ENSP00000402101 ENSP00000263710 ENSP00000389372 ENSP00000380717 ENSP00000441625 ENSP00000438620 ENSP00000441770 Reactome Protein details: Q7Z460
Human Recombinant Protein Products for CLASP1:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
CLASP1 for ontologies About GeneDecksing
CLASP1 Antibody Products:
Assay Products for CLASP1: |
Protein
Domains /
Families
for CLASP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLASP1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z460ProtoNet protein and cluster: Q7Z460 1 Blocks protein family: IPB000357 HEAT repeat
UniProtKB/Swiss-Prot: CLAP1_HUMAN, Q7Z460Similarity: Belongs to the CLASP familySimilarity: Contains 7 HEAT repeats |
Function
for CLASP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CLAP1_HUMAN, Q7Z460Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved inthe nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for thepolarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act atthe cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends tocortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at leastin part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochorewhich is essential for the bipolar alignment of chromosomes on the mitotic spindle Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CLASP1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CLASP1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLASP1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLASP1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CLASP1 (NM_015282) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLASP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLASP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASP1 |
|
Pathways & Interactions
for CLASP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | M Phase | | | 3 | Resolution of Sister Chromatid Cohesion | | | 4 | Cell Cycle | | | 5 | Axon guidance | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CLASP1
5/20 
Reactome Pathways for CLASP1 (see all 20)
CLASP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLASP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/673 Interacting proteins for CLASP1 (Q7Z4601, 2, 3 ENSP000002637104) via UniProtKB, MINT, STRING, and/or I2D (see all 673)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
CLASP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLASP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLASP1
Search CenterWatch for drugs/clinical trials and news about CLASP1 / CLAP1
|
Transcripts
for CLASP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLASP1 gene (4 alternative transcripts): NM_001142273.1 NM_001142274.1 NM_001207051.1 NM_015282.2 Unigene Cluster for CLASP1: Cytoplasmic linker associated protein 1 Hs.469840 [show with all ESTs]Unigene Representative Sequence: NM_01528218 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409078 ENST00000462767 ENST00000452274 ENST00000472776(uc002tnf.3)
ENST00000463621 ENST00000430234 ENST00000491646 ENST00000418989 ENST00000449975
ENST00000474065 ENST00000480007 ENST00000485112 ENST00000263710(uc002tmz.3 uc002tnc.3)
ENST00000455322(uc002tnb.3 uc010yyx.2) ENST00000397587(uc002tna.3 uc010yyw.2 uc010yyy.2 uc010yyz.2 uc010yza.2 uc010yzc.2)
ENST00000541377(uc021vnl.1 uc002tng.1) ENST00000545861 ENST00000541859(uc002tmy.3 uc010yyv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLASP1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLASP1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CLASP1 (NM_015282) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLASP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLASP1 |
Additional cDNA sequence: AB014522.1 AF347693.1 AJ288057.1 AK074338.1 AK091140.1 AK294922.1 AK297259.1 AK297420.1 AK299331.1 AK301814.1 AK302393.1 AY425956.1 BC032563.1 BC112940.1 BC132723.1 BC144107.1 BX648933.1 CR749627.1 CR933722.1 19 DOTS entries: DT.91753193 DT.313630 DT.91729832 DT.100782482 DT.97770637 DT.100782479 DT.121019861 DT.40270276 DT.91916396 DT.75115327 DT.75179731 DT.40110470 DT.40313950 DT.97806905 DT.97818536 DT.100662494 DT.101983108 DT.91725508 DT.91909535 24/141 AceView cDNA sequences (see all 141): T08988 AK091140 CD359902 CK431253 BM669634 AW408170 BM927973 AY425956 BM453810 AW469431 BM987627 NM_015282 AJ288057 CB117700 BX648523 AL698857 BE328429 BM551776 AX746802 BG035267 AL134783 BM466456 AK123216 CR619630
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CLASP1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41a | · | 41b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLASP1
|
Expression
for CLASP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLASP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAATGTAC
About this image
See CLASP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLASP1
SOURCE GeneReport for Unigene cluster: Hs.469840
SABiosciences Expression via Pathway-Focused PCR Array including CLASP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLASP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLASP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASP1 |
Orthologs
for CLASP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CLASP1 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for CLASP1 (if available)
TreeFam Gene Tree for CLASP1 (if available) |
Paralogs
for CLASP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLASP1 gene
- CLASP22
3 SIMAP similar genes for CLASP1 using alignment to 12 protein entries: CLAP1_HUMAN (see all proteins):DKFZp686D1968 DKFZp686D11262 CLASP2
CLASP1 for paralogs About GeneDecksing
|
Genomic Variants
for CLASP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLASP1 (122095352 - 122345352 bp, first 250kb of CLASP1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CLASP1
2 CNVs: 3389 74236 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLASP1 |
|
Disorders
/ Diseases
for CLASP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLASP1 for disorders About GeneDecksing
OMIM gene information: 605852
OMIM disorders: --
1  disease for CLASP1: About MalaCardsbreast cancer
Human Genome Epidemiology (HuGE) Navigator: CLASP1 (4 documents)
Export disorders for CLASP1 gene to outside databases
|
Publications
for CLASP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLASP1 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with CLASP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. (PubMed id 16914514)1, 2, 3 Pereira A.L.... Maiato H. (2006)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
- Asymmetric CLASP-dependent nucleation of noncentrosom al microtubules at the trans-Golgi network. (PubMed id 17543864)1, 2 Efimov A....Kaverina I. (2007)
- Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. (PubMed id 16866869)1, 2 Mimori-Kiyosue Y.... Vorobjev I. (2006)
- CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. (PubMed id 16824950)1, 2 Lansbergen G....Akhmanova A. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment. (PubMed id 16145243)1, 2 Aonuma M....Matsukage A. (2005)
- CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. (PubMed id 15631994)1, 2 Mimori-Kiyosue Y....Akhmanova A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. (PubMed id 12837247)1, 2 Maiato H....Earnshaw W.C. (2003)
|
External Searches for CLASP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLASP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLASP1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CLASP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLASP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLASP1 gene:
Search GeneIP for patents involving CLASP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CLASP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for CLASP1 | | OriGene shRNA RFP for CLASP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLASP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLASP1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLASP1 | | OriGene 3'-UTR Clone for CLASP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLASP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLASP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLASP1 | | OriGene Custom Protein Services for CLASP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLASP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLASP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLASP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLASP1 |
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| | | | Search Tocris compounds for CLASP1 |
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 | | | CLASP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASP1 |
|  |  |  |  | | | | ThermoFisher Antibodies for CLASP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLASP1 |
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