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Aliases for CLASP1 Gene

Aliases for CLASP1 Gene

  • Cytoplasmic Linker Associated Protein 1 2 3 5
  • Multiple Asters Homolog 1 3 4
  • Protein Orbit Homolog 1 3 4
  • Multiple Asters 1 2 3
  • MAST1 3 4
  • Cytoplasmic Linker-Associated Protein 1 4
  • CLIP-Associating Protein 1 3
  • KIAA0622 4
  • HOrbit1 4

External Ids for CLASP1 Gene

Previous GeneCards Identifiers for CLASP1 Gene

  • GC02M119300
  • GC02M120015
  • GC02M122002
  • GC02M122190
  • GC02M121811
  • GC02M114418
  • GC02M122095

Summaries for CLASP1 Gene

Entrez Gene Summary for CLASP1 Gene

  • CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CLASP1 Gene

CLASP1 (Cytoplasmic Linker Associated Protein 1) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Signaling by Robo receptor. GO annotations related to this gene include binding and microtubule plus-end binding. An important paralog of this gene is CLASP2.

UniProtKB/Swiss-Prot for CLASP1 Gene

  • Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Gene Wiki entry for CLASP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLASP1 Gene

Genomics for CLASP1 Gene

Regulatory Elements for CLASP1 Gene

Enhancers for CLASP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G121721 1.4 FANTOM5 Ensembl ENCODE 13.2 -73.0 -72988 2.1 PKNOX1 ATF1 ARNT JUN CEBPG RFX5 FOSL1 FOS NFE2 MAFK CLASP1 RNU4ATAC NIFK NPM1P32
GH02G121564 1.2 Ensembl ENCODE 11.7 +83.0 83015 5.0 PKNOX1 FOXA2 ATF1 ARID4B DMAP1 ZNF48 TCF12 SLC30A9 ZNF766 ZNF263 RNU4ATAC CLASP1 LINC01823 GC02P121556 ENSG00000222467
GH02G121718 0.9 Ensembl ENCODE 13.2 -69.3 -69314 0.6 CTCF KLF11 TEAD1 TRIM22 REST RAD21 ZNF121 SMC3 ZNF143 ZBTB33 CLASP1 RNU4ATAC NPM1P32 NIFK
GH02G121524 1.7 Ensembl ENCODE dbSUPER 4.8 +120.5 120548 9.2 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 TSN NIFK LINC01823 CLASP1 ENSG00000265451 GC02M121346
GH02G121647 1.6 Ensembl ENCODE dbSUPER 5.1 -0.4 -410 5.1 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A LINC01823 CLASP1 NIFK-AS1 GC02M121659
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLASP1 on UCSC Golden Path with GeneCards custom track

Promoters for CLASP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122665 -13 3201 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for CLASP1 Gene

Chromosome:
2
Start:
121,337,776 bp from pter
End:
121,649,587 bp from pter
Size:
311,812 bases
Orientation:
Minus strand

Genomic View for CLASP1 Gene

Genes around CLASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLASP1 Gene

Proteins for CLASP1 Gene

  • Protein details for CLASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z460-CLAP1_HUMAN
    Recommended name:
    CLIP-associating protein 1
    Protein Accession:
    Q7Z460
    Secondary Accessions:
    • A2RU21
    • B7ZLX3
    • F5GWS0
    • O75118
    • Q2KHQ9
    • Q5H9P0
    • Q8N5B8
    • Q9BQT5

    Protein attributes for CLASP1 Gene

    Size:
    1538 amino acids
    Molecular mass:
    169451 Da
    Quaternary structure:
    • Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes. Interacts with MACF1 (By similarity).
    SequenceCaution:
    • Sequence=AAH32563.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAX88872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLASP1 Gene

    Alternative splice isoforms for CLASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLASP1 Gene

Post-translational modifications for CLASP1 Gene

  • Ubiquitination at posLast=11911191
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CLASP1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CLASP1

No data available for DME Specific Peptides for CLASP1 Gene

Domains & Families for CLASP1 Gene

Protein Domains for CLASP1 Gene

Suggested Antigen Peptide Sequences for CLASP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z460

UniProtKB/Swiss-Prot:

CLAP1_HUMAN :
  • Belongs to the CLASP family.
Family:
  • Belongs to the CLASP family.
genes like me logo Genes that share domains with CLASP1: view

No data available for Gene Families for CLASP1 Gene

Function for CLASP1 Gene

Molecular function for CLASP1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Gene Ontology (GO) - Molecular Function for CLASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IPI 23940118
GO:0005515 protein binding IPI 11290329
GO:0008017 microtubule binding IMP 12837247
GO:0043515 kinetochore binding IMP 12837247
GO:0051010 microtubule plus-end binding IDA 12837247
genes like me logo Genes that share ontologies with CLASP1: view
genes like me logo Genes that share phenotypes with CLASP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLASP1 Gene

Localization for CLASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLASP1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLASP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
golgi apparatus 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CLASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IDA,IEA 12837247
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CLASP1: view

Pathways & Interactions for CLASP1 Gene

genes like me logo Genes that share pathways with CLASP1: view

Pathways by source for CLASP1 Gene

Gene Ontology (GO) - Biological Process for CLASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000226 microtubule cytoskeleton organization IMP 24859005
GO:0001578 microtubule bundle formation IMP 12837247
GO:0006903 vesicle targeting IMP 24859005
GO:0007020 microtubule nucleation IMP 17543864
genes like me logo Genes that share ontologies with CLASP1: view

No data available for SIGNOR curated interactions for CLASP1 Gene

Transcripts for CLASP1 Gene

Unigene Clusters for CLASP1 Gene

Cytoplasmic linker associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLASP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for CLASP1 Gene

GeneLoc Exon Structure for
CLASP1
ECgene alternative splicing isoforms for
CLASP1

Expression for CLASP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLASP1 Gene

Protein differential expression in normal tissues from HIPED for CLASP1 Gene

This gene is overexpressed in Bone (18.5) and Breast (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLASP1 Gene



Protein tissue co-expression partners for CLASP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLASP1 Gene:

CLASP1

SOURCE GeneReport for Unigene cluster for CLASP1 Gene:

Hs.469840

Evidence on tissue expression from TISSUES for CLASP1 Gene

  • Nervous system(4.8)
  • Eye(4.3)
  • Blood(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CLASP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLASP1 Gene

Orthologs for CLASP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLASP1 34 35
  • 98.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CLASP1 34 35
  • 93.41 (n)
oppossum
(Monodelphis domestica)
Mammalia CLASP1 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLASP1 34 35
  • 90.12 (n)
mouse
(Mus musculus)
Mammalia Clasp1 34 16 35
  • 89.66 (n)
rat
(Rattus norvegicus)
Mammalia Clasp1 34
  • 89.42 (n)
chicken
(Gallus gallus)
Aves CLASP1 34 35
  • 82.99 (n)
lizard
(Anolis carolinensis)
Reptilia CLASP1 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clasp1 34
  • 76.19 (n)
zebrafish
(Danio rerio)
Actinopterygii clasp1a 34 35
  • 73.29 (n)
CABZ01114089.1 35
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta chb 36 34 35
  • 46.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007623 34
  • 44.32 (n)
worm
(Caenorhabditis elegans)
Secernentea cls-3 35
  • 26 (a)
ManyToMany
cls-2 35
  • 25 (a)
ManyToMany
cls-1 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3398 35
  • 43 (a)
OneToMany
Species where no ortholog for CLASP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLASP1 Gene

ENSEMBL:
Gene Tree for CLASP1 (if available)
TreeFam:
Gene Tree for CLASP1 (if available)

Paralogs for CLASP1 Gene

Paralogs for CLASP1 Gene

genes like me logo Genes that share paralogs with CLASP1: view

Variants for CLASP1 Gene

Sequence variations from dbSNP and Humsavar for CLASP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs180755563 Pathogenic 121,530,932(+) GAGGG(A/C/G/T)AGTAC intron-variant, nc-transcript-variant
rs181195449 Pathogenic 121,530,929(+) AGTGA(A/C/G)GGCAG intron-variant, nc-transcript-variant
rs188343279 Pathogenic 121,530,930(+) GTGAG(A/G)GCAGT intron-variant, nc-transcript-variant
rs370715569 Pathogenic 121,530,887(+) CCATC(C/T)TTTTC intron-variant, nc-transcript-variant
rs374299350 Pathogenic 121,530,909(+) CTACT(A/C/G/T)TCCAA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CLASP1 Gene

Variant ID Type Subtype PubMed ID
dgv736e214 CNV loss 21293372
esv2660340 CNV deletion 23128226
esv2663674 CNV deletion 23128226
esv2720659 CNV deletion 23290073
esv2720660 CNV deletion 23290073
esv2759088 CNV gain 17122850
esv27830 CNV loss 19812545
esv3560042 CNV deletion 23714750
esv3560043 CNV deletion 23714750
esv3584045 CNV loss 25503493
esv3592206 CNV loss 21293372
esv3592207 CNV loss 21293372
esv3592208 CNV gain 21293372
esv3592209 CNV gain 21293372
esv3592212 CNV gain 21293372
esv3592214 CNV gain 21293372
nsv1011665 CNV gain 25217958
nsv1110351 CNV duplication 24896259
nsv1139732 CNV duplication 24896259
nsv1151014 CNV duplication 26484159
nsv2898 CNV deletion 18451855
nsv459163 CNV gain 19166990
nsv582798 CNV loss 21841781
nsv582808 CNV gain 21841781
nsv582809 CNV gain 21841781
nsv979112 CNV duplication 23825009

Variation tolerance for CLASP1 Gene

Gene Damage Index Score: 3.09; 50.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLASP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLASP1 Gene

Disorders for CLASP1 Gene

Relevant External Links for CLASP1

Genetic Association Database (GAD)
CLASP1
Human Genome Epidemiology (HuGE) Navigator
CLASP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLASP1

No disorders were found for CLASP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLASP1 Gene

Publications for CLASP1 Gene

  1. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. (PMID: 16914514) Pereira A.L. … Maiato H. (Mol. Biol. Cell 2006) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. (PMID: 17543864) Efimov A. … Kaverina I. (Dev. Cell 2007) 3 4 64

Products for CLASP1 Gene

Sources for CLASP1 Gene

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