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Aliases for CLASP1 Gene

Aliases for CLASP1 Gene

  • Cytoplasmic Linker Associated Protein 1 2 3
  • Cytoplasmic Linker-Associated Protein 1 3 4
  • Multiple Asters Homolog 1 3 4
  • Protein Orbit Homolog 1 3 4
  • Multiple Asters 1 2 3
  • KIAA0622 4 6
  • MAST1 3 4
  • CLIP-Associating Protein 1 3
  • HOrbit1 4

External Ids for CLASP1 Gene

Summaries for CLASP1 Gene

Entrez Gene Summary for CLASP1 Gene

  • CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CLASP1 Gene

CLASP1 (Cytoplasmic Linker Associated Protein 1) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule binding and kinetochore binding. An important paralog of this gene is CLASP2.

UniProtKB/Swiss-Prot for CLASP1 Gene

  • Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Gene Wiki entry for CLASP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLASP1 Gene

Genomics for CLASP1 Gene

Genomic Location for CLASP1 Gene

Start:
121,337,776 bp from pter
End:
121,649,587 bp from pter
Size:
311,812 bases
Orientation:
Minus strand

Genomic View for CLASP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLASP1 Gene

Regulatory Elements for CLASP1 Gene

Proteins for CLASP1 Gene

  • Protein details for CLASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z460-CLAP1_HUMAN
    Recommended name:
    CLIP-associating protein 1
    Protein Accession:
    Q7Z460
    Secondary Accessions:
    • A2RU21
    • B7ZLX3
    • F5GWS0
    • O75118
    • Q2KHQ9
    • Q5H9P0
    • Q8N5B8
    • Q9BQT5

    Protein attributes for CLASP1 Gene

    Size:
    1538 amino acids
    Molecular mass:
    169451 Da
    Quaternary structure:
    • Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes. Interacts with MACF1 (By similarity).
    SequenceCaution:
    • Sequence=AAH32563.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAX88872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLASP1 Gene

    Alternative splice isoforms for CLASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLASP1 Gene

Proteomics data for CLASP1 Gene at MOPED

Post-translational modifications for CLASP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys873 and Lys1191

No data available for DME Specific Peptides for CLASP1 Gene

Domains for CLASP1 Gene

Protein Domains for CLASP1 Gene

Suggested Antigen Peptide Sequences for CLASP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z460

UniProtKB/Swiss-Prot:

CLAP1_HUMAN
Family:
  • Belongs to the CLASP family.:
    • Q7Z460
Similarity:
  • Contains 7 HEAT repeats.:
    • Q7Z460
genes like me logo Genes that share domains with CLASP1: view

No data available for Gene Families for CLASP1 Gene

Function for CLASP1 Gene

Molecular function for CLASP1 Gene

UniProtKB/Swiss-Prot Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Gene Ontology (GO) - Molecular Function for CLASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 11290329
GO:0008017 microtubule binding IMP 12837247
GO:0043515 kinetochore binding IMP 12837247
GO:0051010 microtubule plus-end binding IDA 12837247
genes like me logo Genes that share ontologies with CLASP1: view

Phenotypes for CLASP1 Gene

GenomeRNAi human phenotypes for CLASP1:
genes like me logo Genes that share phenotypes with CLASP1: view

miRNA for CLASP1 Gene

miRTarBase miRNAs that target CLASP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLASP1 Gene

Localization for CLASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLASP1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLASP1 Gene COMPARTMENTS Subcellular localization image for CLASP1 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for CLASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 12837247
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005794 Golgi apparatus IDA 15631994
GO:0005813 centrosome IDA 12837247
GO:0005828 kinetochore microtubule TAS 12837247
genes like me logo Genes that share ontologies with CLASP1: view

Pathways for CLASP1 Gene

genes like me logo Genes that share pathways with CLASP1: view

Pathways by source for CLASP1 Gene

Gene Ontology (GO) - Biological Process for CLASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000226 microtubule cytoskeleton organization IGI 15631994
GO:0000278 mitotic cell cycle TAS --
GO:0001578 microtubule bundle formation IMP 12837247
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with CLASP1: view

Transcripts for CLASP1 Gene

Unigene Clusters for CLASP1 Gene

Cytoplasmic linker associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLASP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for CLASP1 Gene

GeneLoc Exon Structure for
CLASP1
ECgene alternative splicing isoforms for
CLASP1

Expression for CLASP1 Gene

mRNA expression in normal human tissues for CLASP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLASP1 Gene

SOURCE GeneReport for Unigene cluster for CLASP1 Gene Hs.469840

genes like me logo Genes that share expressions with CLASP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLASP1 Gene

Orthologs for CLASP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLASP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLASP1 35
  • 98.61 (n)
  • 98.23 (a)
CLASP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLASP1 35
  • 90.12 (n)
  • 97.24 (a)
CLASP1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLASP1 35
  • 93.41 (n)
  • 98.62 (a)
CLASP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clasp1 35
  • 89.66 (n)
  • 97.76 (a)
Clasp1 16
Clasp1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLASP1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Clasp1 35
  • 89.42 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves CLASP1 35
  • 82.99 (n)
  • 94.45 (a)
CLASP1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLASP1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clasp1 35
  • 76.19 (n)
  • 88.69 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01114089.1 36
  • 71 (a)
OneToMany
clasp1a 35
  • 73.29 (n)
  • 82.52 (a)
clasp1a 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007623 35
  • 44.32 (n)
  • 36.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta chb 35
  • 46.41 (n)
  • 37.11 (a)
chb 36
  • 30 (a)
OneToMany
chb 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea cls-1 36
  • 20 (a)
ManyToMany
cls-2 36
  • 25 (a)
ManyToMany
cls-3 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3398 36
  • 43 (a)
OneToMany
Species with no ortholog for CLASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLASP1 Gene

ENSEMBL:
Gene Tree for CLASP1 (if available)
TreeFam:
Gene Tree for CLASP1 (if available)

Paralogs for CLASP1 Gene

Paralogs for CLASP1 Gene

genes like me logo Genes that share paralogs with CLASP1: view

Variants for CLASP1 Gene

Sequence variations from dbSNP and Humsavar for CLASP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1066 -- 121,338,913(-) GAGTC(C/T)CTTGT utr-variant-3-prime
rs192608 -- 121,634,863(+) GTCAA(A/G)CTTTT intron-variant
rs287785 -- 121,631,633(+) Aggcc(A/G)ggcgc intron-variant
rs287786 -- 121,631,649(+) ctcac(A/G)cctgt intron-variant
rs287787 -- 121,614,116(+) ccagg(A/C)ctcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLASP1 Gene

Variant ID Type Subtype PubMed ID
esv2720659 CNV Deletion 23290073
nsv2898 CNV Loss 18451855
esv2663674 CNV Deletion 23128226
esv2660340 CNV Deletion 23128226
nsv874976 CNV Gain 21882294
dgv1243e1 CNV Complex 17122850
nsv459163 CNV Gain 19166990
esv27830 CNV Loss 19812545
esv2720660 CNV Deletion 23290073

Relevant External Links for CLASP1 Gene

HapMap Linkage Disequilibrium report
CLASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLASP1 Gene

Disorders for CLASP1 Gene

Relevant External Links for CLASP1

Genetic Association Database (GAD)
CLASP1
Human Genome Epidemiology (HuGE) Navigator
CLASP1
genes like me logo Genes that share disorders with CLASP1: view

No data available for UniProtKB/Swiss-Prot for CLASP1 Gene

Publications for CLASP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. (PMID: 16914514) Pereira A.L. … Maiato H. (Mol. Biol. Cell 2006) 2 3 4
  3. CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. (PMID: 16824950) Lansbergen G. … Akhmanova A. (Dev. Cell 2006) 3 4
  4. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. (PMID: 16866869) Mimori-Kiyosue Y. … Vorobjev I. (Genes Cells 2006) 3 4
  5. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. (PMID: 17543864) Efimov A. … Kaverina I. (Dev. Cell 2007) 3 4

Products for CLASP1 Gene

  • antibodies-online proteins for CLASP1
  • antibodies-online antibodies for CLASP1
  • antibodies-online kits for CLASP1

Sources for CLASP1 Gene

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