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CLASP1 Gene

protein-coding   GIFtS: 64
GCID: GC02M122095

Cytoplasmic Linker Associated Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytoplasmic Linker Associated Protein 11 2     MAST12 3
Multiple Asters 11 2     KIAA06223 5
Cytoplasmic Linker-Associated Protein 12 3     CLIP-Associating Protein 12
Multiple Asters Homolog 12 3     hOrbit13
Protein Orbit Homolog 12 3     

External Ids:    HGNC: 170881   Entrez Gene: 233322   Ensembl: ENSG000000740547   OMIM: 6058525   UniProtKB: Q7Z4603   

Export aliases for CLASP1 gene to outside databases

Previous GC identifers: GC02M119300 GC02M120015 GC02M122002 GC02M122190 GC02M121811 GC02M114418


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLASP1 Gene:
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM
179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the
spindle (Maiato et al., 2003 (PubMed 12837247)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CLASP1 Gene:
CLASP1 (cytoplasmic linker associated protein 1) is a protein-coding gene. Diseases associated with CLASP1 include breast cancer, and malaria. GO annotations related to this gene include microtubule binding and kinetochore binding. An important paralog of this gene is CLASP2.

UniProtKB/Swiss-Prot: CLAP1_HUMAN, Q7Z460
Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved
in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the
polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May
act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their
plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is
regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing
function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Gene Wiki entry for CLASP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLASP1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   aMEF-2   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CLASP1 promoter sequence
   Search Chromatin IP Primers for CLASP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLASP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.2-q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q14.2-q14.3

CLASP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLASP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M122095:  view genomic region     (about GC identifiers)

Start:
122,095,352 bp from pter      End:
122,407,163 bp from pter
Size:
311,812 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLAP1_HUMAN, Q7Z460 (See protein sequence)
Recommended Name: CLIP-associating protein 1  
Size: 1538 amino acids; 169451 Da
Subunit: Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may
be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes. Interacts with MACF1 (By
similarity)
Sequence caution: Sequence=AAH32563.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAX88872.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for CLASP1:
4K92 (3D)    
Secondary accessions: O75118 Q2KHQ9 Q5H9P0 Q8N5B8 Q9BQT5
Alternative splicing: 3 isoforms:  Q7Z460-1   Q7Z460-2   Q7Z460-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLASP1: NX_Q7Z460

Explore proteomics data for CLASP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys873, Lys1191
  • Modification sites at PhosphoSitePlus

  • See CLASP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001135745.1  NP_001135746.1  NP_001193980.1  NP_056097.1  

    ENSEMBL proteins: 
     ENSP00000386442   ENSP00000400562   ENSP00000447929   ENSP00000392886   ENSP00000402101  
     ENSP00000263710   ENSP00000389372   ENSP00000380717   ENSP00000441625   ENSP00000438620  
     ENSP00000441770  
    Reactome Protein details: Q7Z460

    CLASP1 Human Recombinant Protein Products:

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    Novus Biologicals CLASP1 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLASP1

    CLASP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLASP1
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    Novus Biologicals CLASP1 Antibodies
    Abcam antibodies for CLASP1
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    ThermoFisher Antibody for CLASP1
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    CLASP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CLASP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLASP1
    Cloud-Clone Corp. CLIAs for CLASP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR028399 CLASP_metazoan
     IPR000357 HEAT
     IPR024395 CLASP_N_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z460

    ProtoNet protein and cluster: Q7Z460

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: CLAP1_HUMAN, Q7Z460
    Similarity: Belongs to the CLASP family
    Similarity: Contains 7 HEAT repeats


    CLASP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLAP1_HUMAN, Q7Z460
    Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved
    in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the
    polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May
    act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their
    plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is
    regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing
    function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI11290329
    GO:0008017microtubule binding IMP12837247
    GO:0043515kinetochore binding IMP12837247
    GO:0051010microtubule plus-end binding IDA12837247
         
    CLASP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLASP1:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLASP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLASP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLASP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLASP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLASP1:
    hsa-mir-16-5p (MIRT031634)

    Block miRNA regulation of human, mouse, rat CLASP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLASP1 (see all 72):
    hsa-miR-411* hsa-miR-15a hsa-miR-219-5p hsa-miR-3921 hsa-miR-3161 hsa-miR-3142 hsa-miR-3613-3p hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLASP1
    Predesigned siRNA for gene silencing in human, mouse, rat CLASP1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CLASP1

    Clone
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    OriGene clones in human, mouse for CLASP1 (see all 18)
    OriGene ORF clones in mouse, rat for CLASP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CLASP1 (NM_015282)
    Sino Biological Human cDNA Clone for CLASP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLASP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLASP1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLASP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLAP1_HUMAN, Q7Z460: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network
    (Probable). Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic
    spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from
    telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire
    microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    cytosol4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA12837247
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005794Golgi apparatus IDA15631994
    GO:0005813centrosome IDA12837247
    GO:0005828kinetochore microtubule TAS12837247

    CLASP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLASP1 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    5L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CLASP1
        Signaling by Slit

    1 BioSystems Pathway for CLASP1
        Regulation of Microtubule Cytoskeleton


    Selected Reactome Pathways for CLASP1 (see all 8)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Role of Abl in Robo-Slit signaling
    Loss of proteins required for interphase microtubule organization,from the centrosome



    CLASP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CLASP1: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLASP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLASP1 (Q7Z4601, 2, 3 ENSP000002637104) via UniProtKB, MINT, STRING, and/or I2D (see all 750)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIF1BO603331, 2, 3, ENSP000002639344EBI-913476,EBI-465633 MINT-8080001 MINT-8080014 MINT-8080046 I2D: score=1 STRING: ENSP00000263934
    SPAG5Q96R061, 2, 3, ENSP000003233004EBI-913476,EBI-413317 MINT-8080001 MINT-8080014 MINT-8080057 I2D: score=1 STRING: ENSP00000323300
    PHLDB2Q86SQ02, 3, ENSP000003775024MINT-8080087 I2D: score=1 STRING: ENSP00000377502
    TLN1Q9Y4902, 3MINT-7947479 I2D: score=1 
    YWHAGP619812, 3, ENSP000003063304MINT-50883 I2D: score=4 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization IGI15631994
    GO:0000278mitotic cell cycle TAS--
    GO:0001578microtubule bundle formation IMP12837247
    GO:0007020microtubule nucleation IMP17543864

    CLASP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLASP1 (CLAP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLASP1 gene (4 alternative transcripts): 
    NM_001142273.1  NM_001142274.1  NM_001207051.1  NM_015282.2  

    Unigene Cluster for CLASP1:

    Cytoplasmic linker associated protein 1
    Hs.469840  [show with all ESTs]
    Unigene Representative Sequence: NM_015282
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409078 ENST00000452274 ENST00000472776(uc002tnf.3) ENST00000463621
    ENST00000430234 ENST00000491646 ENST00000418989 ENST00000449975 ENST00000474065
    ENST00000480007 ENST00000485112 ENST00000263710(uc002tmz.3 uc002tnc.3)
    ENST00000455322(uc002tnb.3 uc010yyx.2) ENST00000397587(uc002tna.3 uc010yyw.2 uc010yyy.2 uc010yyz.2 uc010yza.2 uc010yzc.2)
    ENST00000541377(uc021vnl.1 uc002tng.1) ENST00000545861 ENST00000541859(uc002tmy.3 uc010yyv.2)

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    Selected qRT-PCR Assays for microRNAs that regulate CLASP1 (see all 72):
    hsa-miR-411* hsa-miR-15a hsa-miR-219-5p hsa-miR-3921 hsa-miR-3161 hsa-miR-3142 hsa-miR-3613-3p hsa-miR-200b
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    GenScript: all cDNA clones in your preferred vector (see all 3): CLASP1 (NM_015282)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLASP1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLASP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLASP1
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      QuantiFast Probe-based Assays in human, mouse, rat CLASP1

    Additional mRNA sequence: 

    AB014522.1 AF347693.1 AJ288057.1 AK074338.1 AK091140.1 AK294922.1 AK297259.1 AK297420.1 
    AK299331.1 AK301814.1 AK302393.1 AY425956.1 BC032563.1 BC112940.1 BC132723.1 BC144107.1 
    BX648933.1 CR749627.1 CR933722.1 

    19 DOTS entries:

    DT.91753193  DT.313630  DT.91729832  DT.100782482  DT.97770637  DT.100782479  DT.121019861  DT.40270276 
    DT.91916396  DT.75115327  DT.75179731  DT.40110470  DT.40313950  DT.97806905  DT.97818536  DT.100662494 
    DT.101983108  DT.91725508  DT.91909535 

    Selected AceView cDNA sequences (see all 141):

    F13138 CR619630 AF347693 BM466456 AK123216 CB117700 AL134783 BX648523 
    BE328429 BM551776 AL698857 AX746802 BG035267 CD359902 AJ288057 NM_015282 
    BM987627 CK431253 AK091140 T08988 BM669634 AY425956 AW408170 BM927973 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLASP1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                -                                               -                           
    SP2:                                                                                -                                                           -           -   
    SP3:                                                                                                                                -           -           -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
    SP1:        -                                   -                                                                     
    SP2:        -                                                                                                         
    SP3:                                            -                 -                                                   
    SP4:                                            -                                                                     
    SP5:                                                              -                                                   


    ECgene alternative splicing isoforms for CLASP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLASP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAATGTAC
    CLASP1 Expression
    About this image

    CLASP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLASP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469840
        Pathway & Disease-focused RT2 Profiler PCR Array including CLASP1: 
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLASP1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clasp11 , 5 CLIP associating protein 11, 5 89.66(n)1
    97.76(a)1
      1 (52.14 cM)5
    767071  NM_001081276.11  NP_001074745.11 
     1183890585 
    chicken
    (Gallus gallus)
    Aves CLASP11 cytoplasmic linker associated protein 1 82.99(n)
    94.45(a)
      429042  XM_004942910.1  XP_004942967.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLASP16
    cytoplasmic linker associated protein 1
    88(a)
    1 ↔ 1
    1(84024817-84222465)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ069088.12   -- 78.81(n)    BJ069088.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clasp1a1 cytoplasmic linker associated protein 1a 73.29(n)
    82.52(a)
      562077  NM_001115139.1  NP_001108611.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chb1 , 3 mitosis GTP binding3
    chromosome bows1
    38(a)3
    46.41(n)1
    37.11(a)1
      3 78C23
    439011  NM_079912.41  NP_524651.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cls-36
    cls-26
    (see all 3)
    Protein CLS-3 (cls-3) mRNA, complete cds
    Protein CLS-2, isoform a (cls-2) mRNA, complete cd...
    (see all 3)
    26(a)
    25(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9186556-9191109) WBGene00013847
    III(9055052-9058882) WBGene00000549


    ENSEMBL Gene Tree for CLASP1 (if available)
    TreeFam Gene Tree for CLASP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLASP1 gene
    CLASP22  
    3 SIMAP similar genes for CLASP1 using alignment to 11 protein entries:     CLAP1_HUMAN (see all proteins):
    DKFZp686D1968    DKFZp686D11262    CLASP2

    CLASP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLASP1 (see all 5302)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756610851,2
    F--122094921(+) AATGTA/GTATTA 4 -- int11Minor allele frequency- G:0.12WA 118
    rs1475230871,2
    --122094932(+) ATATAC/TATATT 4 -- int10--------
    rs2005316001,2
    C--122094953(+) GTATC-/TACTCT 4 -- int10--------
    rs1395513021,2
    --122095025(+) TCAAGC/TGATTC 4 -- int10--------
    rs1135556631,2
    C,F--122095112(+) GACGGG/AGTTTT 4 -- int11Minor allele frequency- A:0.50WA 2
    rs27132471,2
    C--122095123(-) ggcgaC/Tgtggc 4 -- int10--------
    rs25803751,2
    C,F,A--122095172(-) AGGCCA/GAGGCG 4 -- int111Minor allele frequency- G:0.48NA WA CSA EA 371
    rs1918043571,2
    C--122095231(+) AAAGAG/TCTCTT 4 -- int10--------
    rs1166508771,2
    F--122095325(+) TGGTGG/CTGGTA 4 -- int11Minor allele frequency- C:0.03WA 118
    rs1475895731,2
    --122095481(+) AACAAA/GTAAGA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for CLASP1 (122095352 - 122345352 bp, first 250kb of CLASP1)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CLASP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720660CNV Deletion23290073
    esv2663674CNV Deletion23128226
    esv2660340CNV Deletion23128226
    esv2720659CNV Deletion23290073
    esv27830CNV Loss19812545
    nsv2898CNV Loss18451855
    nsv459163CNV Gain19166990
    nsv874976CNV Gain21882294
    dgv1243e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605852    OMIM disorders: --

    2 diseases for CLASP1:    About MalaCards
    breast cancer    malaria


    CLASP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLASP1
    Human Genome Epidemiology (HuGE) Navigator: CLASP1 (4 documents)

    Export disorders for CLASP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLASP1 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with CLASP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. (PubMed id 16914514)1, 2, 3 Pereira A.L.... Maiato H. (Mol. Biol. Cell 2006)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. (PubMed id 17543864)1, 2 Efimov A.... Kaverina I. (Dev. Cell 2007)
    6. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. (PubMed id 16866869)1, 2 Mimori-Kiyosue Y.... Vorobjev I. (Genes Cells 2006)
    7. CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. (PubMed id 16824950)1, 2 Lansbergen G....Akhmanova A. (Dev. Cell 2006)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment. (PubMed id 16145243)1, 2 Aonuma M....Matsukage A. (Cell Struct. Funct. 2005)
    10. CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. (PubMed id 15631994)1, 2 Mimori-Kiyosue Y....Akhmanova A. (J. Cell Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23332 HGNC: 17088 AceView: CLASP1 Ensembl:ENSG00000074054 euGenes: HUgn23332
    ECgene: CLASP1 H-InvDB: CLASP1

    (According to HUGE)
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    HUGE: KIAA0622

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLASP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLASP1 gene:
    Search GeneIP for patents involving CLASP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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