Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CKS2 Gene

protein-coding   GIFtS: 64
GCID: GC09P091926

CDC28 Protein Kinase Regulatory Subunit 2

(Previous name: CDC28 protein kinase 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CDC28 Protein Kinase Regulatory Subunit 21 2
CDC28 Protein Kinase 21 2
CKS-22 3
CKSHS22
CKS1(S. Cerevisiae Cdc28/Cdc2 Kinase Subunit) Homolog-22
Cyclin-Dependent Kinases Regulatory Subunit 22

External Ids:    HGNC: 20001   Entrez Gene: 11642   Ensembl: ENSG000001239757   OMIM: 1169015   UniProtKB: P335523   

Export aliases for CKS2 gene to outside databases

Previous GC identifers: GC09P082941 GC09P083794 GC09P085513 GC09P087415 GC09P089155 GC09P091115 GC09P061760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CKS2 Gene:
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells,
which reflects specialized role for the encoded protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKS2 Gene:
CKS2 (CDC28 protein kinase regulatory subunit 2) is a protein-coding gene. Diseases associated with CKS2 include meningioma, and pancreatic cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS1B.

UniProtKB/Swiss-Prot: CKS2_HUMAN, P33552
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
function

Gene Wiki entry for CKS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKS2 gene promoter:
         Pax-5   Pbx1a   AP-4   YY1   CREB   Max   deltaCREB   FOXO1a   FOXO1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKS2 promoter sequence
   Search Chromatin IP Primers for CKS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22

CKS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKS2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P091926:  view genomic region     (about GC identifiers)

Start:
91,926,113 bp from pter      End:
91,931,618 bp from pter
Size:
5,506 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CKS2_HUMAN, P33552 (See protein sequence)
Recommended Name: Cyclin-dependent kinases regulatory subunit 2  
Size: 79 amino acids; 9860 Da
Subunit: Forms a homohexamer that can probably bind six kinase subunits
1 PDB 3D structure from and Proteopedia for CKS2:
1CKS (3D)    
Secondary accessions: Q6FGI9 Q6LET5

Explore the universe of human proteins at neXtProt for CKS2: NX_P33552

Explore proteomics data for CKS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys4, Lys11
  • Modification sites at PhosphoSitePlus

  • See CKS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001818.1  
    ENSEMBL proteins: 
     ENSP00000364976  

    CKS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CKS2
    OriGene Protein Over-expression Lysate for CKS2
    OriGene MassSpec for CKS2
    OriGene Custom Protein Services for CKS2
    GenScript Custom Purified and Recombinant Proteins Services for CKS2
    Novus Biologicals CKS2 Proteins
    Novus Biologicals CKS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CKS2
    Cloud-Clone Corp. Proteins for CKS2

    CKS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CKS2
    OriGene Custom Antibody Services for CKS2
    Novus Biologicals CKS2 Antibodies
    Abcam antibodies for CKS2 (P61024, P33552)
    Cloud-Clone Corp. Antibodies for CKS2
    ThermoFisher Antibodies for CKS2
    LSBio Antibodies in human, mouse, rat for CKS2

    CKS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CKS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CKS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CKS2
    Cloud-Clone Corp. CLIAs for CKS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000789 Cyclin-dep_kinase_reg-sub

    Graphical View of Domain Structure for InterPro Entry P33552

    ProtoNet protein and cluster: P33552

    1 Blocks protein domain: IPB000789 Cyclin-dependent kinase

    UniProtKB/Swiss-Prot: CKS2_HUMAN, P33552
    Similarity: Belongs to the CKS family


    CKS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CKS2_HUMAN, P33552
    Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
    function

         Genatlas biochemistry entry for CKS2:
    protein p9,9kDa,inhibiting the activation of cyclin A/CDK2 kinase,involved in the G1/S transition of the cell
    cycle,homologous to yeast (S pombe) CKS2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IEA--
         
    CKS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CKS2:
     Decreased viability of wild-ty  Proliferating cells 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cks2):
     endocrine/exocrine gland  reproductive system 

    CKS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cks2tm1Sir for CKS2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CKS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CKS2:
    hsa-let-7b-5p (MIRT052270), hsa-mir-124-3p (MIRT022264)

    Block miRNA regulation of human, mouse, rat CKS2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CKS2:
    hsa-miR-493* hsa-miR-26a hsa-miR-26b hsa-miR-3670 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidCKS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CKS2
    Predesigned siRNA for gene silencing in human, mouse, rat CKS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CKS2

    Clone
    Products:
         
    OriGene clones in human, mouse for CKS2 (see all 7)
    OriGene ORF clones in mouse, rat for CKS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKS2 (NM_001827)
    Sino Biological Human cDNA Clone for CKS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CKS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CKS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CKS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Small cell lung cancer
    Small cell lung cancer
    2Pathways in cancer
    Pathways in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for CKS2):
        Pathways in cancer
    Small cell lung cancer


    CKS2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CKS2: 
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CKS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CKS2 (P335522, 3 ENSP000003649764) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3MINT-63684 I2D: score=5 
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-67632 I2D: score=5 STRING: ENSP00000300181
    CKS1BP610243, ENSP000003110834I2D: score=2 STRING: ENSP00000311083
    CCNA2P202483, ENSP000002740264I2D: score=1 STRING: ENSP00000274026
    CCNB1P146353, ENSP000002564424I2D: score=2 STRING: ENSP00000256442
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS2227411
    GO:0007049cell cycle NAS15504738
    GO:0007051spindle organization NAS15504738
    GO:0007127meiosis I IEA--
    GO:0008283cell proliferation TAS8211159

    CKS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CKS2 gene: 
    NM_001827.1  

    Unigene Cluster for CKS2:

    CDC28 protein kinase regulatory subunit 2
    Hs.83758  [show with all ESTs]
    Unigene Representative Sequence: BQ898943
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314355(uc004aqh.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CKS2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CKS2:
    hsa-miR-493* hsa-miR-26a hsa-miR-26b hsa-miR-3670 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidCKS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CKS2
    Predesigned siRNA for gene silencing in human, mouse, rat CKS2
    Clone
    Products:
         
    OriGene clones in human, mouse for CKS2 (see all 7)
    OriGene ORF clones in mouse, rat for CKS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKS2 (NM_001827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKS2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CKS2
    OriGene qSTAR qPCR primer pairs in human, mouse for CKS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CKS2
      QuantiTect SYBR Green Assays in human, mouse, rat CKS2
      QuantiFast Probe-based Assays in human, mouse, rat CKS2

    Additional mRNA sequence: 

    BC006458.1 BC020345.1 BT006630.1 CR407630.1 CR542118.1 X54942.1 

    12 DOTS entries:

    DT.99934837  DT.114320  DT.114321  DT.75181992  DT.91728433  DT.97845047  DT.121158670  DT.40268194 
    DT.75157925  DT.95369334  DT.97845048  DT.100872056 

    Selected AceView cDNA sequences (see all 178):

    AW172922 BM783987 BM850917 AA705174 BM785451 BM838320 BQ431907 BM787863 
    BE888351 BU517078 CR601576 R00665 AI375953 BQ938035 CB529929 BM786241 
    AA397813 BG171423 AI160521 BC006458 BM764862 H89939 AW949804 CR621720 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CKS2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:              -           -               
    SP2:              -           -               
    SP3:              -                           
    SP4:                                          


    ECgene alternative splicing isoforms for CKS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CKS2 expression in normal human tissues (normalized intensities)      CKS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTGTATTC
    CKS2 Expression
    About this image


    CKS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Secondary Spermatocyte Seminiferous Tubules
             Seminiferous Tubules
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CKS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83758
        Pathway & Disease-focused RT2 Profiler PCR Array including CKS2: 
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CKS2
    OriGene qSTAR qPCR primer pairs in human, mouse for CKS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CKS2
    QuantiTect SYBR Green Assays in human, mouse, rat CKS2
    QuantiFast Probe-based Assays in human, mouse, rat CKS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CKS2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cks21 , 5 CDC28 protein kinase regulatory subunit 21, 5 95.36(n)1
    98.73(a)1
      13 (26.12 cM)5
    661971  NM_025415.31  NP_079691.11 
     516452325 
    chicken
    (Gallus gallus)
    Aves CKS21 CDC28 protein kinase regulatory subunit 2 83.54(n)
    88.61(a)
      768830  XM_001231966.3  XP_001231967.1 
    lizard
    (Anolis carolinensis)
    Reptilia CKS26
    CDC28 protein kinase regulatory subunit 2
    95(a)
    1 ↔ 1
    2(36880245-36884893)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.129792 Xenopus laevis transcribed sequence with moderate similarity more 83.83(n)    AW637048.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160342 Transcribed sequence with moderate similarity to protein more 77.73(n)    CB360639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cks85A6
    Cyclin-dependent kinase subunit 85A
    52(a)
    1 → many
    3R(4540922-4544178)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G12B.271 Y71G12B.27 59.09(n)
    69.7(a)
      171745  NM_058495.3  NP_490896.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKS16
    Cyclin-dependent protein kinase regulatory subunit...
    27(a)
    1 → many
    II(504854-505306) YBR135W
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.43012 Vitis vinifera transcribed sequence with strong similarity more 75.9(n)    CA808342.1 


    ENSEMBL Gene Tree for CKS2 (if available)
    TreeFam Gene Tree for CKS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CKS2 gene
    CKS1B2  CKS1BP32  
    1 SIMAP similar gene for CKS2 using alignment to 1 protein entry:     CKS2_HUMAN:
    CKS1B

    CKS2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CKS2
    PGOHUM00000247284 PGOHUM00000235801 PGOHUM00000236653


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CKS2 (see all 118)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78645321,2
    C,F,A--91924153(+) cctttG/Actgca 1 -- us2k18Minor allele frequency- A:0.30NA CSA WA EA 367
    rs1396021891,2
    --91924161(+) GCAACC/TTGTTT 1 -- us2k10--------
    rs78563151,2
    C,F--91924250(+) gggaaC/Tgcagc 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1505169731,2
    --91924297(+) TTAAGA/TTGAAG 1 -- us2k10--------
    rs1932591191,2
    --91924304(+) GAAGGG/TGCTCT 1 -- us2k10--------
    rs32116391,2
    C,F--91924382(+) agttcG/Aagacc 1 -- us2k12Minor allele frequency- A:0.03NS WA 174
    rs32116401,2
    C,F--91924384(+) ttcgaG/Aaccag 1 -- us2k11Minor allele frequency- A:0.01NS 174
    rs1456339511,2
    --91924399(+) GCCAAA/CATGAT 1 -- us2k10--------
    rs32116421,2
    C,F--91924498(+) ggaggG/Aggagg 1 -- us2k1 trp32Minor allele frequency- A:0.02NS CSA 168
    rs32116431,2
    C,F--91924515(+) tgagcC/Aaagat 1 -- us2k12Minor allele frequency- A:0.05NS CSA 168

    HapMap Linkage Disequilibrium report for CKS2 (91926113 - 91931618 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CKS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831651CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CKS2
    DNA2.0 Custom Variant and Variant Library Synthesis for CKS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 116901    OMIM disorders: --

    8 diseases for CKS2:    About MalaCards
    meningioma    pancreatic cancer    cholangiocarcinoma    hepatocellular carcinoma
    pancreatitis    breast cancer    lung cancer    prostatitis


    CKS2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CKS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 18498131 (4), 8697818 (1)
    cancer 0 1 8697818 (1)

    Genetic Association Database (GAD): CKS2

    Export disorders for CKS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CKS2 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with CKS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PubMed id 2227411)1, 2, 3, 9 Richardson H.E.... Reed S.I. (Genes Dev. 1990)
    2. Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22. (PubMed id 8697818)1, 3, 9 Demetrick D.J....Beach D.H. (Cytogenet. Cell Genet. 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. (PubMed id 8211159)1, 2 Parge H.E.... Tainer J.A. (Science 1993)
    5. Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. (PubMed id 18498131)1, 9 Lan Y....Wang F. (Int. J. Cancer 2008)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. miR-26a and its target CKS2 modulate cell growth and tumorigenesis of papillary thyroid carcinoma. (PubMed id 23861775)1 Lv M....Lv Z. (PLoS ONE 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Oncogenic potential of cyclin kinase subunit-2 in cholangiocarcinoma. (PubMed id 23121546)1 Shen D.Y....Zhang Z.M. (Liver Int. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1164 HGNC: 2000 AceView: CKS2 Ensembl:ENSG00000123975 euGenes: HUgn1164
    ECgene: CKS2 Kegg: 1164 H-InvDB: CKS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CKS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CKS2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cks2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CKS2 gene:
    Search GeneIP for patents involving CKS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CKS2   OriGene RNAi products in human, mouse, rat for CKS2  
     OriGene qPCR primer pairs and template standards for CKS2   OriGene Protein Over-expression Lysate for CKS2  
     OriGene MassSpec something-or-other for CKS2   OriGene clones in human, mouse for CKS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CKS2   OriGene Purified Protein for CKS2  
     OriGene ORF clones in mouse, rat for CKS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CKS2   OriGene Custom Protein Services for CKS2  

     
     
     Block miRNA regulation of human, mouse, rat CKS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CKS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKS2 Predesigned siRNA for gene silencing in human, mouse, rat CKS2
     QuantiFast Probe-based Assays in human, mouse, rat CKS2 QuantiTect SYBR Green Assays in human, mouse, rat CKS2
     PCR Arrays including human, mouse, rat CKS2 Search Chromatin IP Primers for CKS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CKS2  GeneGlobe Interaction Network for CKS2
     Regulatory tfbs in CKS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CKS2 GenScript cDNA clones with any tag delivered in your preferred vector for CKS2
     GenScript Custom Assay Services for CKS2 GenScript Custom overexpressing Cell Line Services for CKS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CKS2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CKS2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CKS2 antibodies
     CKS2 proteins
     CKS2 lysates
     Antibodies for CKS2
     See all of Abcam's Antibodies, Kits and Proteins for CKS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CKS2
     Proteins for CKS2
     Antibodies for CKS2
     ELISAs for CKS2
     CLIAs for CKS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CKS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKS2
     SwitchGear 3'UTR luciferase reporter plasmids for CKS2
     SwitchGear Promoter luciferase reporter plasmids for CKS2
     ThermoFisher Antibodies for CKS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CKS2
     LSBio Antibodies in human, mouse, rat for CKS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CKS2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4