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Aliases for CKS2 Gene

Aliases for CKS2 Gene

  • CDC28 Protein Kinase Regulatory Subunit 2 2 3
  • CDC28 Protein Kinase 2 2 3
  • CKS-2 3 4
  • CKS1(S. Cerevisiae Cdc28/Cdc2 Kinase Subunit) Homolog-2 3
  • Cyclin-Dependent Kinases Regulatory Subunit 2 3
  • CKSHS2 3

External Ids for CKS2 Gene

Summaries for CKS2 Gene

Entrez Gene Summary for CKS2 Gene

  • CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKS2 Gene

CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) is a Protein Coding gene. Among its related pathways are Pathways in cancer and Small cell lung cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS1B.

UniProtKB/Swiss-Prot for CKS2 Gene

  • Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function

Gene Wiki entry for CKS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKS2 Gene

Genomics for CKS2 Gene

Genomic Location for CKS2 Gene

Start:
89,311,198 bp from pter
End:
89,316,703 bp from pter
Size:
5,506 bases
Orientation:
Plus strand

Genomic View for CKS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKS2 Gene

Regulatory Elements for CKS2 Gene

Proteins for CKS2 Gene

  • Protein details for CKS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33552-CKS2_HUMAN
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 2
    Protein Accession:
    P33552
    Secondary Accessions:
    • Q6FGI9
    • Q6LET5

    Protein attributes for CKS2 Gene

    Size:
    79 amino acids
    Molecular mass:
    9860 Da
    Quaternary structure:
    • Forms a homohexamer that can probably bind six kinase subunits

    Three dimensional structures from OCA and Proteopedia for CKS2 Gene

neXtProt entry for CKS2 Gene

Proteomics data for CKS2 Gene at MOPED

Post-translational modifications for CKS2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4 and Lys11

Other Protein References for CKS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CKS2 Gene

Domains for CKS2 Gene

Protein Domains for CKS2 Gene

UniProtKB/Swiss-Prot:

CKS2_HUMAN
Family:
  • Belongs to the CKS family.:
    • P33552
genes like me logo Genes that share domains with CKS2: view

No data available for Gene Families for CKS2 Gene

Function for CKS2 Gene

Molecular function for CKS2 Gene

GENATLAS Biochemistry: protein p9,9kDa,inhibiting the activation of cyclin A/CDK2 kinase,involved in the G1/S transition of the cell cycle,homologous to yeast (S pombe) CKS2
UniProtKB/Swiss-Prot Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function

Gene Ontology (GO) - Molecular Function for CKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
genes like me logo Genes that share ontologies with CKS2: view
genes like me logo Genes that share phenotypes with CKS2: view

Animal Models for CKS2 Gene

MGI Knock Outs for CKS2:

miRNA for CKS2 Gene

miRTarBase miRNAs that target CKS2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CKS2 Gene

Localization for CKS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKS2 Gene COMPARTMENTS Subcellular localization image for CKS2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for CKS2 Gene

Pathways for CKS2 Gene

genes like me logo Genes that share pathways with CKS2: view

Pathways by source for CKS2 Gene

2 KEGG pathways for CKS2 Gene

Gene Ontology (GO) - Biological Process for CKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 2227411
GO:0007049 cell cycle --
GO:0007127 meiosis I IEA --
GO:0008283 cell proliferation TAS 8211159
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CKS2: view

Transcripts for CKS2 Gene

mRNA/cDNA for CKS2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(178) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CKS2 Gene

CDC28 protein kinase regulatory subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for CKS2 Gene

GeneLoc Exon Structure for
CKS2
ECgene alternative splicing isoforms for
CKS2

Expression for CKS2 Gene

mRNA expression in normal human tissues for CKS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKS2 Gene

This gene is overexpressed in Testis (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKS2 Gene

SOURCE GeneReport for Unigene cluster for CKS2 Gene Hs.83758

genes like me logo Genes that share expressions with CKS2: view

Orthologs for CKS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKS2 36
  • 100 (n)
  • 100 (a)
CKS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CKS2 36
  • 95.36 (n)
  • 100 (a)
CKS2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKS2 36
  • 97.89 (n)
  • 98.73 (a)
CKS2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cks2 36
  • 95.36 (n)
  • 98.73 (a)
Cks2 16
Cks2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CKS2 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cks2 36
  • 94.94 (n)
  • 98.73 (a)
chicken
(Gallus gallus)
Aves CKS2 36
  • 83.54 (n)
  • 88.61 (a)
lizard
(Anolis carolinensis)
Reptilia CKS2 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12979 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cks2 36
  • 79.32 (n)
  • 89.87 (a)
Str.6313 36
zebrafish
(Danio rerio)
Actinopterygii cks2 36
  • 73.33 (n)
  • 81.33 (a)
cks2 37
  • 78 (a)
OneToOne
Dr.16034 36
fruit fly
(Drosophila melanogaster)
Insecta Cks85A 37
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cks-1 37
  • 47 (a)
OneToMany
Y71G12B.27 36
  • 59.09 (n)
  • 69.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKS1 37
  • 27 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4301 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
Species with no ortholog for CKS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKS2 Gene

ENSEMBL:
Gene Tree for CKS2 (if available)
TreeFam:
Gene Tree for CKS2 (if available)

Paralogs for CKS2 Gene

Paralogs for CKS2 Gene

Selected SIMAP similar genes for CKS2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CKS2 Gene

genes like me logo Genes that share paralogs with CKS2: view

Variants for CKS2 Gene

Sequence variations from dbSNP and Humsavar for CKS2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1410461 -- 89,315,607(-) ATATA(C/T)TTATG intron-variant
rs1887680 -- 89,313,769(-) TTCAA(A/T)TAATC intron-variant
rs2094523 -- 89,309,972(-) TCCAG(C/T)GCAGT upstream-variant-2KB
rs3080706 -- 89,315,534(-) TTTTT(-/TTT)ACTTC intron-variant
rs3211639 -- 89,309,467(+) agttc(A/G)agacc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CKS2 Gene

Variant ID Type Subtype PubMed ID
nsv831651 CNV Gain 17160897

Relevant External Links for CKS2 Gene

HapMap Linkage Disequilibrium report
CKS2

Disorders for CKS2 Gene

(2) Novoseek inferred disease relationships for CKS2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 5
cancer 0 1

Relevant External Links for CKS2

Genetic Association Database (GAD)
CKS2
genes like me logo Genes that share disorders with CKS2: view

No data available for UniProtKB/Swiss-Prot for CKS2 Gene

Publications for CKS2 Gene

  1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PMID: 2227411) Richardson H.E. … Reed S.I. (Genes Dev. 1990) 2 3 4 23
  2. Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22. (PMID: 8697818) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1996) 2 3 23
  3. Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. (PMID: 18498131) Lan Y. … Wang F. (Int. J. Cancer 2008) 3 23
  4. Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. (PMID: 8211159) Parge H.E. … Tainer J.A. (Science 1993) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CKS2 Gene

  • Addgene plasmids for CKS2

Sources for CKS2 Gene

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