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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKS2 Gene

protein-coding   GIFtS: 56
GCID: GC09P091926

CDC28 protein kinase regulatory subunit 2

(Previous name: CDC28 protein kinase 2 )
 Explore 8 diseases affiliated with
CKS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CKS2    

Aliases
for CKS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CDC28 Protein Kinase Regulatory Subunit 21 2
CDC28 Protein Kinase 21 2
CKS-22 3
CKSHS22
CKS1(S. Cerevisiae Cdc28/Cdc2 Kinase Subunit) Homolog-22
Cyclin-Dependent Kinases Regulatory Subunit 22

External Ids:    HGNC: 20001   Entrez Gene: 11642   Ensembl: ENSG000001239757   OMIM: 1169015   UniProtKB: P335523   

Export aliases for CKS2 gene to outside databases

Previous GC identifers: GC09P082941 GC09P083794 GC09P085513 GC09P087415 GC09P089155 GC09P091115 GC09P061760


Summaries
for CKS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CKS2:
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which
reflects specialized role for the encoded protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CKS2_HUMAN, P33552
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function

Gene Wiki entry for CKS2


Genomic Views
for CKS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKS2 gene promoter:
         Pax-5   Pbx1a   AP-4   YY1   CREB   Max   deltaCREB   FOXO1a   FOXO1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CKS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22

CKS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKS2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P091926:  view genomic region     (about GC identifiers)

Start:
 91,926,113 bp from pter      End:
 91,931,618 bp from pter
Size:
 5,506 bases      Orientation:
 plus strand

Proteins
for CKS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CKS2_HUMAN, P33552 (See protein sequence)
Recommended Name: Cyclin-dependent kinases regulatory subunit 2  
Size: 79 amino acids; 9860 Da
Subunit: Forms a homohexamer that can probably bind six kinase subunits
1 PDB 3D structure from and Proteopedia for CKS2:
1CKS (3D)    
Secondary accessions: Q6FGI9

Explore the universe of human proteins at neXtProt for CKS2: NX_P33552

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P33552

    • CKS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001818.1  
    ENSEMBL proteins: 
     ENSP00000364976  

    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for CKS2
    Uscn Proteins for CKS2


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    Uscn ELISAs and CLIAs for CKS2

    Protein Domains /
    Families
    for CKS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CKS2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000789 Cyclin-dep_kinase_reg-sub

    Graphical View of Domain Structure for InterPro Entry P33552

    ProtoNet protein and cluster: P33552

    1 Blocks protein family: IPB000789 Cyclin-dependent kinase

    UniProtKB/Swiss-Prot: CKS2_HUMAN, P33552
    Similarity: Belongs to the CKS family


    Function
    for CKS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CKS2_HUMAN, P33552
    Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function

         Genatlas biochemistry entry for CKS2:
    protein p9,9kDa,inhibiting the activation of cyclin A/CDK2 kinase,involved in the G1/S transition of the cell
    cycle,homologous to yeast (S pombe) CKS2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CKS2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKS2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CKS2:
    hsa-miR-493* hsa-miR-26a hsa-miR-26b hsa-miR-3670 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmid: CKS2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKS2 (see all 7)
    OriGene shRNA RFP: CKS2
    OriGene siRNA: CKS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKS2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CKS2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKS2 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: CKS2 (NM_001827)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKS2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CKS2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CKS2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016538cyclin-dependent protein kinase regulator activity IEA--


    CKS2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CKS2:
     Decreased viability of wild-ty  Proliferating cells 

    Animal Models:
         Mouse knock-out Cks2tm1Sir for CKS2
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cks2):
     endocrine/exocrine gland  reproductive system 

    CKS2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CKS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CKS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/30 Interacting proteins for CKS2 (P335522, 3 ENSP000003649764) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3MINT-63684 I2D: score=5 
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-67632 I2D: score=5 STRING: ENSP00000300181
    CKS1BP610243, ENSP000003110834I2D: score=2 STRING: ENSP00000311083
    CCNA2P202483, ENSP000002740264I2D: score=1 STRING: ENSP00000274026
    CCNB1P146353, ENSP000002564424I2D: score=2 STRING: ENSP00000256442
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity TAS2227411
    GO:0007049cell cycle NAS15504738
    GO:0007051spindle organization NAS15504738
    GO:0007127meiosis I IEA--
    GO:0008283cell proliferation TAS8211159


    CKS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CKS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CKS2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKS2
    Search CenterWatch for drugs/clinical trials and news about CKS2 

    Transcripts
    for CKS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CKS2 gene: 
    NM_001827.1  

    Unigene Cluster for CKS2:

    CDC28 protein kinase regulatory subunit 2
    Hs.83758  [show with all ESTs]
    Unigene Representative Sequence: BQ898943
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314355(uc004aqh.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKS2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CKS2:
    hsa-miR-493* hsa-miR-26a hsa-miR-26b hsa-miR-3670 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmid: CKS2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKS2 (see all 7)
    OriGene shRNA RFP: CKS2
    OriGene siRNA: CKS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKS2
    Clone
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    GenScript: all cDNA clones in your preferred vector: CKS2 (NM_001827)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKS2

    Additional cDNA sequence: 

    BC006458.1 BC020345.1 BT006630.1 CR407630.1 CR542118.1 X54942.1 

    12 DOTS entries:

    DT.99934837  DT.114320  DT.114321  DT.75181992  DT.91728433  DT.97845047  DT.121158670  DT.40268194 
    DT.75157925  DT.95369334  DT.97845048  DT.100872056 

    24/178 AceView cDNA sequences (see all 178):

    AW172922 AI021915 BM449578 BM783987 BM760458 BU506848 BM850917 AA705174 
    CR621720 BM785451 BQ431907 BM838320 CR542118 BM787863 BE888351 BU192805 
    BU517078 AI375953 CR601576 R00665 BQ938035 CB529929 BM786241 BG171423 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CKS2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:              -           -               
    SP2:              -           -               
    SP3:              -                           
    SP4:                                          


    ECgene alternative splicing isoforms for CKS2

    Expression
    for CKS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTGTATTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CKS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CKS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKS2

    SOURCE GeneReport for Unigene cluster: Hs.83758
        SABiosciences Expression via Pathway-Focused PCR Array including CKS2: 
              Cell Cycle in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CKS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CKS2 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CKS21 CDC28 protein kinase regulatory subunit 2 83.54(n)
    88.61(a)    		   768830  XM_001231966.2  XP_001231967.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CKS26
    		 --
    		 95(a)
    		 1 ↔ 1
    		 2(36880245-36884888)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.129792 Xenopus laevis transcribed sequence with moderate similarity more 83.83(n)    AW637048.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.160342 Transcribed sequence with moderate similarity to protein more 77.73(n)    CB360639.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cks30A6
    Cks85A6
    		 Cyclin-dependent kinase subunit 85A
    		 73(a)
    51(a)
    		 possible ortholog
    possible ortholog
    		 2L(9330767-9331981)
    3R(4540922-4544178)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y71G12B.271 Protein Y71G12B.27 58.33(n)
    67.65(a)    		   171745  NM_058495.2  NP_490896.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CKS26
    CKS16
    		 cyclin-dependent kinases regulatory subunit 1
    		 61(a)
    57(a)
    		 many ↔ many
    many ↔ many
    		 2(11912212-11913297)
    2(11910723-11911685)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 cyclin-dependent kinases regulatory subunit 1, put...
    		 58(a)
    		 1 → many
    		 3(2571059-2571530)


    ENSEMBL Gene Tree for CKS2 (if available)
    TreeFam Gene Tree for CKS2 (if available) 

    Paralogs
    for CKS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CKS2 gene
    CKS1B2  
    1 SIMAP similar gene for CKS2 using alignment to 2 protein entries:     CKS2_HUMAN (see all proteins):
    CKS1B

    CKS2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CKS2
    PGOHUM00000247284 PGOHUM00000235801 PGOHUM00000236653


    Genomic Variants
    for CKS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/174 NCBI SNPs in CKS2 are shown (see all 174)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs78645321,2
    		C,F,A,--91924153(+) CCTTTG/ACTGCA 1 -- us2k18Minor allele frequency- A:0.30NA CSA WA EA 367
    rs1396021891,2
    		--91924161(+) GCAACC/TTGTTT 1 -- us2k10--------
    rs78563151,2
    		C,--91924250(+) gggaaC/Tgcagc 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1505169731,2
    		--91924297(+) TTAAGA/TTGAAG 1 -- us2k10--------
    rs1932591191,2
    		--91924304(+) GAAGGG/TGCTCT 1 -- us2k10--------
    rs32116391,2
    		C,F,--91924382(+) agttcG/Aagacc 1 -- us2k12Minor allele frequency- A:0.03NS WA 174
    rs32116401,2
    		C,F,--91924384(+) ttcgaG/Aaccag 1 -- us2k11Minor allele frequency- A:0.01NS 174
    rs1456339511,2
    		--91924399(+) GCCAAA/CATGAT 1 -- us2k10--------
    rs32116421,2
    		C,F,--91924498(+) ggaggG/Aggagg 1 -- us2k1 trp32Minor allele frequency- A:0.02NS CSA 168
    rs32116431,2
    		C,F,--91924515(+) tgagcC/Aaagat 1 -- us2k12Minor allele frequency- A:0.05NS CSA 168

    HapMap Linkage Disequilibrium report for CKS2 (91926113 - 91931618 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CKS2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKS2
    DNA2.0 Custom Variant and Variant Library Synthesis for CKS2

    Disorders / Diseases
    for CKS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CKS2 for disorders           About GeneDecksing

    OMIM gene information: 116901    OMIM disorders: --

    8 diseases for CKS2:    About MalaCards
    gallbladder carcinoma    hepatocellular carcinoma    gastric cancer    pancreatic cancer
    breast cancer    pancreatitis    carcinoma    prostatitis

    2 Novoseek disease relationships for CKS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 18498131 (4), 8697818 (1)
    cancer 0 1 8697818 (1)


    Export disorders for CKS2 gene to outside databases

    Publications
    for CKS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CKS2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CKS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PubMed id 2227411)1, 2, 3, 9 Richardson H.E.... Reed S.I. (1990)
    2. Chromosomal mapping of the human genes CKS1 to 8q21 a nd CKS2 to 9q22. (PubMed id 8697818)1, 3, 9 Demetrick D.J....Beach D.H. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. (PubMed id 8211159)1, 2 Parge H.E.... Tainer J.A. (1993)
    5. Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. (PubMed id 18498131)1, 9 Lan Y....Wang F. (2008)
    6. Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overex pression overrides the DNA damage response barrier triggered by activated oncopr oteins. (PubMed id 21697511)1 Liberal V....Reed S.I. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Cyclin-dependent kinase-associated protein Cks2 is as sociated with bladder cancer progression. (PubMed id 21672358)1 Chen R....Xu Y. (2011)

    External Searches for CKS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CKS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1164 HGNC: 2000 AceView: CKS2 Ensembl:ENSG00000123975 euGenes: HUgn1164
    ECgene: CKS2 H-InvDB: CKS2

    Other Databases showing CKS2 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing CKS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CKS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CKS2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cks2/

    Intellectual Property
    for CKS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CKS2 gene:
    Search GeneIP for patents involving CKS2

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