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Aliases for CKS2 Gene

Aliases for CKS2 Gene

  • CDC28 Protein Kinase Regulatory Subunit 2 2 3 5
  • CDC28 Protein Kinase 2 2 3
  • CKS-2 3 4
  • CKS1(S. Cerevisiae Cdc28/Cdc2 Kinase Subunit) Homolog-2 3
  • CKSHS2 3

External Ids for CKS2 Gene

Previous GeneCards Identifiers for CKS2 Gene

  • GC09P082941
  • GC09P083794
  • GC09P085513
  • GC09P087415
  • GC09P089155
  • GC09P091115
  • GC09P091926
  • GC09P061760

Summaries for CKS2 Gene

Entrez Gene Summary for CKS2 Gene

  • CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKS2 Gene

CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) is a Protein Coding gene. Among its related pathways are Pathways in cancer and Small cell lung cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS1B.

UniProtKB/Swiss-Prot for CKS2 Gene

  • Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Gene Wiki entry for CKS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKS2 Gene

Genomics for CKS2 Gene

Regulatory Elements for CKS2 Gene

Enhancers for CKS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CKS2 on UCSC Golden Path with GeneCards custom track

Promoters for CKS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CKS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CKS2 Gene

89,311,195 bp from pter
89,316,703 bp from pter
5,509 bases
Plus strand

Genomic View for CKS2 Gene

Genes around CKS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKS2 Gene

Proteins for CKS2 Gene

  • Protein details for CKS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 2
    Protein Accession:
    Secondary Accessions:
    • Q6FGI9
    • Q6LET5

    Protein attributes for CKS2 Gene

    79 amino acids
    Molecular mass:
    9860 Da
    Quaternary structure:
    • Forms a homohexamer that can probably bind six kinase subunits.

    Three dimensional structures from OCA and Proteopedia for CKS2 Gene

neXtProt entry for CKS2 Gene

Proteomics data for CKS2 Gene at MOPED

Post-translational modifications for CKS2 Gene

  • Ubiquitination at Lys 11
  • Modification sites at PhosphoSitePlus

Other Protein References for CKS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CKS2 Gene

Domains & Families for CKS2 Gene

Protein Domains for CKS2 Gene

Suggested Antigen Peptide Sequences for CKS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CKS family.
  • Belongs to the CKS family.
genes like me logo Genes that share domains with CKS2: view

No data available for Gene Families for CKS2 Gene

Function for CKS2 Gene

Molecular function for CKS2 Gene

GENATLAS Biochemistry:
protein p9,9kDa,inhibiting the activation of cyclin A/CDK2 kinase,involved in the G1/S transition of the cell cycle,homologous to yeast (S pombe) CKS2
UniProtKB/Swiss-Prot Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
genes like me logo Genes that share phenotypes with CKS2: view

Animal Models for CKS2 Gene

MGI Knock Outs for CKS2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKS2 Gene

Localization for CKS2 Gene

Subcellular locations from

Jensen Localization Image for CKS2 Gene COMPARTMENTS Subcellular localization image for CKS2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CKS2 Gene

Pathways & Interactions for CKS2 Gene

genes like me logo Genes that share pathways with CKS2: view

Pathways by source for CKS2 Gene

2 KEGG pathways for CKS2 Gene

Gene Ontology (GO) - Biological Process for CKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 2227411
GO:0007127 meiosis I IEA --
GO:0008283 cell proliferation TAS 8211159
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CKS2: view

No data available for SIGNOR curated interactions for CKS2 Gene

Drugs & Compounds for CKS2 Gene

No Compound Related Data Available

Transcripts for CKS2 Gene

mRNA/cDNA for CKS2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(178) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CKS2 Gene

CDC28 protein kinase regulatory subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for CKS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CKS2 Gene

mRNA expression in normal human tissues for CKS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKS2 Gene

This gene is overexpressed in Testis (x8.2).

Protein differential expression in normal tissues from HIPED for CKS2 Gene

This gene is overexpressed in Bone (38.2) and Fetal ovary (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKS2 Gene

SOURCE GeneReport for Unigene cluster for CKS2 Gene Hs.83758

genes like me logo Genes that share expression patterns with CKS2: view

Protein tissue co-expression partners for CKS2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CKS2 Gene

Orthologs for CKS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CKS2 35
  • 95.36 (n)
  • 100 (a)
CKS2 36
  • 100 (a)
(Canis familiaris)
Mammalia CKS2 35
  • 97.89 (n)
  • 98.73 (a)
CKS2 36
  • 99 (a)
(Mus musculus)
Mammalia Cks2 35
  • 95.36 (n)
  • 98.73 (a)
Cks2 16
Cks2 36
  • 99 (a)
(Pan troglodytes)
Mammalia CKS2 35
  • 100 (n)
  • 100 (a)
CKS2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cks2 35
  • 94.94 (n)
  • 98.73 (a)
(Monodelphis domestica)
Mammalia CKS2 36
  • 99 (a)
(Gallus gallus)
Aves CKS2 35
  • 83.54 (n)
  • 88.61 (a)
(Anolis carolinensis)
Reptilia CKS2 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cks2 35
  • 79.32 (n)
  • 89.87 (a)
Str.6313 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12979 35
(Danio rerio)
Actinopterygii cks2 35
  • 73.33 (n)
  • 81.33 (a)
Dr.16034 35
cks2 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cks85A 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea Y71G12B.27 35
  • 59.09 (n)
  • 69.7 (a)
cks-1 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKS1 36
  • 27 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4301 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for CKS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKS2 Gene

Gene Tree for CKS2 (if available)
Gene Tree for CKS2 (if available)

Paralogs for CKS2 Gene

Paralogs for CKS2 Gene

(1) SIMAP similar genes for CKS2 Gene using alignment to 1 proteins: Pseudogenes for CKS2 Gene

genes like me logo Genes that share paralogs with CKS2: view

Variants for CKS2 Gene

Sequence variations from dbSNP and Humsavar for CKS2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1410461 -- 89,315,607(-) ATATA(C/T)TTATG intron-variant
rs1887680 -- 89,313,769(-) TTCAA(A/T)TAATC intron-variant
rs117095753 -- 89,313,747(+) AGAAC(A/G)TAGAA intron-variant
rs191791043 -- 89,314,704(+) TTTAC(C/G)GTTCT intron-variant
rs192807087 -- 89,313,621(+) TCCGT(A/G)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CKS2 Gene

Variant ID Type Subtype PubMed ID
nsv831651 CNV Gain 17160897

Variation tolerance for CKS2 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CKS2 Gene

Disorders for CKS2 Gene

Relevant External Links for CKS2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CKS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKS2 Gene

Publications for CKS2 Gene

  1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PMID: 2227411) Richardson H.E. … Reed S.I. (Genes Dev. 1990) 2 3 4 23 67
  2. Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22. (PMID: 8697818) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1996) 2 3 23
  3. Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. (PMID: 18498131) Lan Y. … Wang F. (Int. J. Cancer 2008) 3 23
  4. Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints. (PMID: 24858038) Del RincA^n S.V. … Spruck C. (Oncogene 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for CKS2 Gene

Sources for CKS2 Gene