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Aliases for CKS2 Gene

Aliases for CKS2 Gene

  • CDC28 Protein Kinase Regulatory Subunit 2 2 3 5
  • CDC28 Protein Kinase 2 2 3
  • CKS-2 3 4
  • CKS1(S. Cerevisiae Cdc28/Cdc2 Kinase Subunit) Homolog-2 3
  • Cyclin-Dependent Kinases Regulatory Subunit 2 3
  • CKSHS2 3

External Ids for CKS2 Gene

Previous GeneCards Identifiers for CKS2 Gene

  • GC09P082941
  • GC09P083794
  • GC09P085513
  • GC09P087415
  • GC09P089155
  • GC09P091115
  • GC09P091926
  • GC09P061760

Summaries for CKS2 Gene

Entrez Gene Summary for CKS2 Gene

  • CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKS2 Gene

CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) is a Protein Coding gene. Among its related pathways are Pathways in cancer and Small cell lung cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS1B.

UniProtKB/Swiss-Prot for CKS2 Gene

  • Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Gene Wiki entry for CKS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKS2 Gene

Genomics for CKS2 Gene

Regulatory Elements for CKS2 Gene

Enhancers for CKS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CKS2 on UCSC Golden Path with GeneCards custom track

Promoters for CKS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CKS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CKS2 Gene

Chromosome:
9
Start:
89,311,195 bp from pter
End:
89,316,703 bp from pter
Size:
5,509 bases
Orientation:
Plus strand

Genomic View for CKS2 Gene

Genes around CKS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKS2 Gene

Proteins for CKS2 Gene

  • Protein details for CKS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33552-CKS2_HUMAN
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 2
    Protein Accession:
    P33552
    Secondary Accessions:
    • Q6FGI9
    • Q6LET5

    Protein attributes for CKS2 Gene

    Size:
    79 amino acids
    Molecular mass:
    9860 Da
    Quaternary structure:
    • Forms a homohexamer that can probably bind six kinase subunits.

    Three dimensional structures from OCA and Proteopedia for CKS2 Gene

neXtProt entry for CKS2 Gene

Post-translational modifications for CKS2 Gene

  • Ubiquitination at Lys 11
  • Modification sites at PhosphoSitePlus

Other Protein References for CKS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CKS2 Gene

Domains & Families for CKS2 Gene

Protein Domains for CKS2 Gene

Suggested Antigen Peptide Sequences for CKS2 Gene

Graphical View of Domain Structure for InterPro Entry

P33552

UniProtKB/Swiss-Prot:

CKS2_HUMAN :
  • Belongs to the CKS family.
Family:
  • Belongs to the CKS family.
genes like me logo Genes that share domains with CKS2: view

No data available for Gene Families for CKS2 Gene

Function for CKS2 Gene

Molecular function for CKS2 Gene

GENATLAS Biochemistry:
protein p9,9kDa,inhibiting the activation of cyclin A/CDK2 kinase,involved in the G1/S transition of the cell cycle,homologous to yeast (S pombe) CKS2
UniProtKB/Swiss-Prot Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Gene Ontology (GO) - Molecular Function for CKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 2227411
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IBA --
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with CKS2: view
genes like me logo Genes that share phenotypes with CKS2: view

Animal Models for CKS2 Gene

MGI Knock Outs for CKS2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CKS2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKS2 Gene

Localization for CKS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKS2 Gene COMPARTMENTS Subcellular localization image for CKS2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA --
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with CKS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CKS2 Gene

Pathways & Interactions for CKS2 Gene

genes like me logo Genes that share pathways with CKS2: view

Pathways by source for CKS2 Gene

2 KEGG pathways for CKS2 Gene

Gene Ontology (GO) - Biological Process for CKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007127 meiosis I IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0008283 cell proliferation IEA --
GO:0044772 mitotic cell cycle phase transition IEA --
genes like me logo Genes that share ontologies with CKS2: view

No data available for SIGNOR curated interactions for CKS2 Gene

Drugs & Compounds for CKS2 Gene

No Compound Related Data Available

Transcripts for CKS2 Gene

mRNA/cDNA for CKS2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(178) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CKS2 Gene

CDC28 protein kinase regulatory subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CKS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for CKS2 Gene

GeneLoc Exon Structure for
CKS2
ECgene alternative splicing isoforms for
CKS2

Expression for CKS2 Gene

mRNA expression in normal human tissues for CKS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKS2 Gene

This gene is overexpressed in Testis (x8.2).

Protein differential expression in normal tissues from HIPED for CKS2 Gene

This gene is overexpressed in Bone (38.2) and Fetal ovary (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CKS2 Gene



Protein tissue co-expression partners for CKS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CKS2 Gene:

CKS2

SOURCE GeneReport for Unigene cluster for CKS2 Gene:

Hs.83758
genes like me logo Genes that share expression patterns with CKS2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CKS2 Gene

Orthologs for CKS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CKS2 34
  • 95.36 (n)
  • 100 (a)
CKS2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKS2 34
  • 97.89 (n)
  • 98.73 (a)
CKS2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cks2 34
  • 95.36 (n)
  • 98.73 (a)
Cks2 16
Cks2 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CKS2 34
  • 100 (n)
  • 100 (a)
CKS2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cks2 34
  • 94.94 (n)
  • 98.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CKS2 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CKS2 34
  • 83.54 (n)
  • 88.61 (a)
lizard
(Anolis carolinensis)
Reptilia CKS2 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cks2 34
  • 79.32 (n)
  • 89.87 (a)
Str.6313 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12979 34
zebrafish
(Danio rerio)
Actinopterygii cks2 34
  • 73.33 (n)
  • 81.33 (a)
Dr.16034 34
cks2 35
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cks85A 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.27 34
  • 59.09 (n)
  • 69.7 (a)
cks-1 35
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKS1 35
  • 27 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4301 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for CKS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKS2 Gene

ENSEMBL:
Gene Tree for CKS2 (if available)
TreeFam:
Gene Tree for CKS2 (if available)

Paralogs for CKS2 Gene

Paralogs for CKS2 Gene

(1) SIMAP similar genes for CKS2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CKS2 Gene

genes like me logo Genes that share paralogs with CKS2: view

Variants for CKS2 Gene

Sequence variations from dbSNP and Humsavar for CKS2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs117095753 -- 89,313,747(+) AGAAC(A/G)TAGAA intron-variant
rs10566165 -- 89,315,534(+) GAAGT(-/AA)AAAAA intron-variant
rs138496821 -- 89,315,170(+) AACAG(C/G)CATGT reference, synonymous-codon
rs1410461 -- 89,315,607(-) ATATA(C/T)TTATG intron-variant
rs141029293 -- 89,313,911(+) AAGGC(A/G)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CKS2 Gene

Variant ID Type Subtype PubMed ID
esv3621014 CNV gain 21293372
nsv1041327 CNV gain 25217958
nsv831651 CNV gain 17160897

Variation tolerance for CKS2 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKS2 Gene

Disorders for CKS2 Gene

Relevant External Links for CKS2

Genetic Association Database (GAD)
CKS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKS2

No disorders were found for CKS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKS2 Gene

Publications for CKS2 Gene

  1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PMID: 2227411) Richardson H.E. … Reed S.I. (Genes Dev. 1990) 2 3 4 22 65
  2. Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22. (PMID: 8697818) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1996) 2 3 22 65
  3. Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. (PMID: 18498131) Lan Y. … Wang F. (Int. J. Cancer 2008) 3 22 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. (PMID: 8211159) Parge H.E. … Tainer J.A. (Science 1993) 3 4 65

Products for CKS2 Gene

Sources for CKS2 Gene

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