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CKS1BP3 Gene

pseudogene   GIFtS: 17
GCID: GC05M061807

CDC28 Protein Kinase Regulatory Subunit 1B Pseudogene 3

  Search for CKS1BP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC28 Protein Kinase Regulatory Subunit 1B Pseudogene 31 2

External Ids:    HGNC: 242331   Entrez Gene: 2467152   Ensembl: ENSG000002689427   UniProtKB: D3DV794   UniProtKB: Q5T1784   

Export aliases for CKS1BP3 gene to outside databases

Previous GC identifers: GC05M061824 GC05M061843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CKS1BP3 Gene:
CKS1BP3 (CDC28 protein kinase regulatory subunit 1B pseudogene 3) is a pseudogene. An important paralog of this gene is CKS2.

UniProtKB/TrEMBL: D3DV79 (see all)
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CKS1BP3
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKS1BP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.2   Ensembl cytogenetic band:  5q12.1   HGNC cytogenetic band: 5q12.2

CKS1BP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKS1BP3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M061807:  view genomic region     (about GC identifiers)

Start:
61,807,588 bp from pter      End:
61,808,309 bp from pter
Size:
722 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/TrEMBL: D3DV79 (See protein sequence)
Recommended Name: Cyclin-dependent kinases regulatory subunit  
Size: 57 amino acids; 6795 Da

UniProtKB/TrEMBL: Q5T178 (See protein sequence)

Recommended Name: Cyclin-dependent kinases regulatory subunit  
Size: 79 amino acids; 9660 Da


ENSEMBL proteins: 
 ENSP00000471505  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR000789 Cyclin-dep_kinase_reg-sub

Graphical View of Domain Structure for InterPro Entry D3DV79
Graphical View of Domain Structure for InterPro Entry Q5T178

ProtoNet protein and cluster: D3DV79

UniProtKB/TrEMBL: D3DV79
Similarity: Belongs to the CKS family

UniProtKB/TrEMBL: Q5T178
Similarity: Belongs to the CKS family


CKS1BP3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
UniProtKB/TrEMBL Summary: D3DV79 (see all)
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
function (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity ----
     
CKS1BP3 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005654nucleoplasm ----

CKS1BP3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for CKS1BP3

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
GO:0000082G1/S transition of mitotic cell cycle ----
GO:0000278mitotic cell cycle ----
GO:0007049cell cycle ----
GO:0008283cell proliferation ----

CKS1BP3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000600888
miRNA
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Selected AceView cDNA sequences (see all 74):

H68268 H42079 AI348243 AI312104 BQ225114 AI090262 BI256707 BG104737 
AI362835 AW514667 AA293140 AI989380 AU127144 AI339996 AA583187 AI828996 
R54703 AA772418 AI146955 AA459292 BF900364 AI991988 BM753071 BE778624 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

CKS1BP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CKS1BP3 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves CKS1B6
Gallus gallus CDC28 protein kinase regulatory subu...
97(a)
1 → many
25(1283199-1283700)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
95(a)
1 → many
GL344009.1(58670-62240)
zebrafish
(Danio rerio)
Actinopterygii cks1b6
CDC28 protein kinase regulatory subunit 1B
87(a)
1 → many
19(8457561-8460768) ENSDARG00000007971
fruit fly
(Drosophila melanogaster)
Insecta Cks85A6
Cyclin-dependent kinase subunit 85A
54(a)
1 → many
3R(4540922-4544178)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.276
Protein Y71G12B.27 (Y71G12B.27) mRNA, complete cds...
37(a)
many ↔ many
I(1797435-1798695) WBGene00022162
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKS16
Cyclin-dependent protein kinase regulatory subunit...
26(a)
1 → many
II(504854-505306) YBR135W
        Species with no ortholog for CKS1BP3

ENSEMBL Gene Tree for CKS1BP3 (if available)
TreeFam Gene Tree for CKS1BP3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CKS1BP3 gene
CKS22  CKS1B2  

CKS1BP3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing CKS1BP3
DNA2.0 Custom Variant and Variant Library Synthesis for CKS1BP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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  --

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 246715 HGNC: 24233 AceView: CKS1BP3 Ensembl:ENSG00000268942 euGenes: HUgn246715
ECgene: CKS1BP3 H-InvDB: CKS1BP3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CKS1BP3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CKS1BP3 gene:
Search GeneIP for patents involving CKS1BP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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