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Aliases for CKS1B Gene

Aliases for CKS1B Gene

  • CDC28 Protein Kinase Regulatory Subunit 1B 2 3 5
  • CDC28 Protein Kinase 1B 2 3
  • CKS1 3 4
  • NB4 Apoptosis/Differentiation Related Protein 3
  • Cyclin-Dependent Kinases Regulatory Subunit 1 3
  • Cell Division Control Protein CKS1 3
  • CDC2-Associated Protein CKS1 3
  • PNAS-16 3
  • PNAS-18 3
  • Ckshs1 3
  • CKS-1 4

External Ids for CKS1B Gene

Previous GeneCards Identifiers for CKS1B Gene

  • GC05M061960
  • GC01P150678
  • GC01P151722
  • GC01P152163
  • GC01P151760
  • GC01P153213
  • GC01P154947
  • GC01P126308

Summaries for CKS1B Gene

Entrez Gene Summary for CKS1B Gene

  • CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

GeneCards Summary for CKS1B Gene

CKS1B (CDC28 Protein Kinase Regulatory Subunit 1B) is a Protein Coding gene. Diseases associated with CKS1B include Clear Cell Adenofibroma. Among its related pathways are Cell cycle Role of SCF complex in cell cycle regulation and Pathways in cancer. GO annotations related to this gene include kinase activity and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS2.

UniProtKB/Swiss-Prot for CKS1B Gene

  • Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Gene Wiki entry for CKS1B Gene

Additional gene information for CKS1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKS1B Gene

Genomics for CKS1B Gene

Regulatory Elements for CKS1B Gene

Enhancers for CKS1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H155123 1.7 FANTOM5 ENCODE dbSUPER 10.2 +153.4 153381 8 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 KIAA0907 GON4L CLK2 UBAP2L MSTO1 ENSG00000271267 MSTO2P LOC101928120 RUSC1-AS1 SHC1
GH01H153984 1 ENCODE 10.1 -988.5 -988471 3 HDGF ARID4B SIN3A ZNF2 GLIS2 ZNF143 ZNF207 KLF7 FOS SP3 S100A4 S100A16 CREB3L4 CKS1B S100A3 HAX1 RAB13 GC01P153977
GH01H154998 1.9 FANTOM5 ENCODE dbSUPER 1.5 +29.8 29810 11 MLX YBX1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A PPARGC1A GON4L CLK2 UBAP2L KIAA0907 ENSG00000271267 MSTO1 RUSC1-AS1 THBS3 YY1AP1 FLAD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CKS1B on UCSC Golden Path with GeneCards custom track

Promoters for CKS1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014006 158 2801 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for CKS1B Gene

Chromosome:
1
Start:
154,974,642 bp from pter
End:
154,979,249 bp from pter
Size:
4,608 bases
Orientation:
Plus strand

Genomic View for CKS1B Gene

Genes around CKS1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKS1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKS1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKS1B Gene

Proteins for CKS1B Gene

  • Protein details for CKS1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61024-CKS1_HUMAN
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 1
    Protein Accession:
    P61024
    Secondary Accessions:
    • P33551

    Protein attributes for CKS1B Gene

    Size:
    79 amino acids
    Molecular mass:
    9660 Da
    Quaternary structure:
    • Forms a homohexamer that can probably bind six kinase subunits.

    Three dimensional structures from OCA and Proteopedia for CKS1B Gene

neXtProt entry for CKS1B Gene

Post-translational modifications for CKS1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CKS1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CKS1B Gene

Domains & Families for CKS1B Gene

Gene Families for CKS1B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CKS1B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P61024

UniProtKB/Swiss-Prot:

CKS1_HUMAN :
  • Belongs to the CKS family.
Family:
  • Belongs to the CKS family.
genes like me logo Genes that share domains with CKS1B: view

Function for CKS1B Gene

Molecular function for CKS1B Gene

UniProtKB/Swiss-Prot Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Phenotypes From GWAS Catalog for CKS1B Gene

Gene Ontology (GO) - Molecular Function for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2227411
GO:0016301 kinase activity IEA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IBA --
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with CKS1B: view
genes like me logo Genes that share phenotypes with CKS1B: view

Animal Models for CKS1B Gene

MGI Knock Outs for CKS1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CKS1B
  • Applied Biological Materials Clones for CKS1B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKS1B Gene

Localization for CKS1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKS1B gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA --
GO:0005654 nucleoplasm TAS --
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with CKS1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CKS1B Gene

Pathways & Interactions for CKS1B Gene

genes like me logo Genes that share pathways with CKS1B: view

Gene Ontology (GO) - Biological Process for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0016310 phosphorylation IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA --
GO:0045859 regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CKS1B: view

No data available for SIGNOR curated interactions for CKS1B Gene

Drugs & Compounds for CKS1B Gene

(3) Drugs for CKS1B Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluoxetine Approved, Vet_approved Pharma Channel blocker, Target 243
Meta Vanadate Experimental Pharma Target 0

(1) Additional Compounds for CKS1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CKS1B: view

Transcripts for CKS1B Gene

Unigene Clusters for CKS1B Gene

CDC28 protein kinase regulatory subunit 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CKS1B
  • Applied Biological Materials Clones for CKS1B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CKS1B Gene

No ASD Table

Relevant External Links for CKS1B Gene

GeneLoc Exon Structure for
CKS1B
ECgene alternative splicing isoforms for
CKS1B

Expression for CKS1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CKS1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CKS1B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CKS1B Gene



NURSA nuclear receptor signaling pathways regulating expression of CKS1B Gene:

CKS1B

SOURCE GeneReport for Unigene cluster for CKS1B Gene:

Hs.374378

Evidence on tissue expression from TISSUES for CKS1B Gene

  • Nervous system(4.5)
  • Muscle(4.1)
  • Liver(3.1)
  • Lung(2.6)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with CKS1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKS1B Gene

Orthologs for CKS1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CKS1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKS1B 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia CKS1B 33
  • 96.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CKS1B 33
  • 94.94 (n)
mouse
(Mus musculus)
Mammalia Cks1b 33 16 34
  • 93.25 (n)
rat
(Rattus norvegicus)
Mammalia Cks1b 33
  • 92.83 (n)
oppossum
(Monodelphis domestica)
Mammalia CKS1B 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CKS1B 33 34
  • 81.01 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 95 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cks1b 33
  • 79.65 (n)
Str.7452 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3190 33
zebrafish
(Danio rerio)
Actinopterygii cks1b 33 34
  • 79.73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1323 33
fruit fly
(Drosophila melanogaster)
Insecta Cks85A 33 34
  • 67.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003796 33
  • 66.2 (n)
worm
(Caenorhabditis elegans)
Secernentea cks-1 33 34
  • 65.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKS1 34 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
Species where no ortholog for CKS1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKS1B Gene

ENSEMBL:
Gene Tree for CKS1B (if available)
TreeFam:
Gene Tree for CKS1B (if available)

Paralogs for CKS1B Gene

Paralogs for CKS1B Gene

(1) SIMAP similar genes for CKS1B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CKS1B Gene

genes like me logo Genes that share paralogs with CKS1B: view

Variants for CKS1B Gene

Sequence variations from dbSNP and Humsavar for CKS1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001011376 -- 154,979,097(+) GGGAT(C/T)ATGTA nc-transcript-variant, utr-variant-3-prime
rs1001131115 -- 154,979,607(+) GTGTC(C/G/T)CAATT downstream-variant-500B
rs1001555057 -- 154,974,540(+) GAGAA(A/C)TGCCC upstream-variant-2KB
rs1001890531 -- 154,973,197(+) TTCTA(C/T)CCTTG intron-variant, upstream-variant-2KB
rs1002352216 -- 154,979,031(+) GCTCT(A/G)TATCC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CKS1B Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489
nsv946409 CNV duplication 23825009

Variation tolerance for CKS1B Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKS1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKS1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKS1B Gene

Disorders for CKS1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CKS1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
clear cell adenofibroma
  • cystadenofibroma
- elite association - COSMIC cancer census association via MalaCards
Search CKS1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for CKS1B

Genetic Association Database (GAD)
CKS1B
Human Genome Epidemiology (HuGE) Navigator
CKS1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKS1B
genes like me logo Genes that share disorders with CKS1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKS1B Gene

Publications for CKS1B Gene

  1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PMID: 2227411) Richardson HE … Reed SI (Genes & development 1990) 2 3 4 22 60
  2. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. (PMID: 8601310) Bourne Y … Tainer JA (Cell 1996) 3 4 22 60
  3. Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. (PMID: 7791211) Arvai AS … Tainer JA (Journal of molecular biology 1995) 3 4 22 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study. (PMID: 18922157) Liu Z … Ding K (Journal of experimental & clinical cancer research : CR 2008) 3 22 60

Products for CKS1B Gene

  • Addgene plasmids for CKS1B

Sources for CKS1B Gene

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