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CKS1B Gene

protein-coding   GIFtS: 63
GCID: GC01P154947

CDC28 Protein Kinase Regulatory Subunit 1B

(Previous name: CDC28 protein kinase 1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CDC28 Protein Kinase Regulatory Subunit 1B1 2     CDC2-Associated Protein CKS12
CKS12 3 5     CDC28 Protein Kinase 12
CDC28 Protein Kinase 1B1 2     Cell Division Control Protein CKS12
CKS-12 3     ckshs12
PNAS-1432     Cyclin-Dependent Kinases Regulatory Subunit 12
PNAS-162     NB4 Apoptosis/Differentiation Related Protein2
PNAS-182     

External Ids:    HGNC: 190831   Entrez Gene: 11632   Ensembl: ENSG000001732077   OMIM: 1169005   UniProtKB: P610243   
ORGUL members:         

Export aliases for CKS1B gene to outside databases

Previous GC identifers: GC05M061960 GC01P150678 GC01P151722 GC01P152163 GC01P151760 GC01P153213 GC01P126308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CKS1B Gene:
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells,
which reflects a specialized role for the encoded protein. At least two transcript variants have been identified
for this gene, and it appears that only one of them encodes a protein. (provided by RefSeq, Sep 2008)

GeneCards Summary for CKS1B Gene:
CKS1B (CDC28 protein kinase regulatory subunit 1B) is a protein-coding gene. Diseases associated with CKS1B include myxofibrosarcoma, and paracoccidioidomycosis. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS2.

UniProtKB/Swiss-Prot: CKS1_HUMAN, P61024
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
function

Gene Wiki entry for CKS1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKS1B gene promoter:
         c-Rel   MAZR   p53   AP-1   HOXA5   STAT3   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CKS1B promoter sequence
   Search Chromatin IP Primers for CKS1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKS1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

CKS1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKS1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154947:  view genomic region     (about GC identifiers)

Start:
154,947,118 bp from pter      End:
154,951,725 bp from pter
Size:
4,608 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CKS1_HUMAN, P61024 (See protein sequence)
Recommended Name: Cyclin-dependent kinases regulatory subunit 1  
Size: 79 amino acids; 9660 Da
Subunit: Forms a homohexamer that can probably bind six kinase subunits
5 PDB 3D structures from and Proteopedia for CKS1B:
1BUH (3D)        1DKS (3D)        1DKT (3D)        2ASS (3D)        2AST (3D)    
Secondary accessions: P33551

Explore the universe of human proteins at neXtProt for CKS1B: NX_P61024

Explore proteomics data for CKS1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys4
  • Modification sites at PhosphoSitePlus

  • See CKS1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001817.1  
    ENSEMBL proteins: 
     ENSP00000357424   ENSP00000357421   ENSP00000311083  
    Reactome Protein details: P61024

    CKS1B Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000789 Cyclin-dep_kinase_reg-sub

    Graphical View of Domain Structure for InterPro Entry P61024

    ProtoNet protein and cluster: P61024

    UniProtKB/Swiss-Prot: CKS1_HUMAN, P61024
    Similarity: Belongs to the CKS family


    CKS1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CKS1_HUMAN, P61024
    Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological
    function

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12813041
    GO:0016301kinase activity ----
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IEA--
         
    CKS1B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CKS1B:
     Decreased influenza A/WSN/33 r  Decreased viability  Decreased viability with cispl  Increased cell death in breast 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cks1b):
     cellular  growth/size/body  hematopoietic system  immune system  mortality/aging 
     reproductive system  tumorigenesis 

    CKS1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cks1btm1Sir for CKS1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKS1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CKS1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKS1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKS1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target CKS1B:
    hsa-mir-425-5p (MIRT039329), hsa-mir-941 (MIRT036562), hsa-mir-197-3p (MIRT048080)

    Block miRNA regulation of human, mouse, rat CKS1B using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CKS1B:
    hsa-miR-3163 hsa-miR-548am hsa-miR-548x hsa-miR-494 hsa-miR-330-3p hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidCKS1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CKS1B
    Predesigned siRNA for gene silencing in human, mouse, rat CKS1B

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CKS1B (see all 6)
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    GenScript: all cDNA clones in your preferred vector: CKS1B (NM_001826)
    Sino Biological Human cDNA Clone for CKS1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKS1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKS1B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CKS1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKS1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    CKS1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CKS1B About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    SCF(Skp2)-mediated degradation of p27/p210.86
    Cyclin A-Cdk2-associated events at S phase entry0.85
    Cyclin E associated events during G1/S transition0.86
    S Phase0.78
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3E2F mediated regulation of DNA replication
    G1/S Transition0.81
    Mitotic G1-G1/S phases0.81
    4Cyclins and Cell Cycle Regulation
    G1 Phase0.31
    Cyclin D associated events in G10.31
    5Cell cycle Regulation of G1 S transition part 1
    Cell cycle Role of SCF complex in cell cycle regulation0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CKS1B
        Mitotic Roles of Polo Like Kinases

    3 GeneGo (Thomson Reuters) Pathways for CKS1B
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Role of SCF complex in cell cycle regulation

    1 BioSystems Pathway for CKS1B
        FOXM1 transcription factor network


    2 Reactome Pathways for CKS1B
        SCF(Skp2)-mediated degradation of p27/p21
    Cyclin D associated events in G1


    2 Kegg Pathways  (Kegg details for CKS1B):
        Pathways in cancer
    Small cell lung cancer


    CKS1B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CKS1B: 
              Cell Cycle in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CKS1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CKS1B (P610241, 2, 3 ENSP000003110834) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249411, 2, 3, ENSP000002669704EBI-456371,EBI-375096 MINT-25066 I2D: score=6 STRING: ENSP00000266970
    SKP2Q133091, 2, 3, ENSP000002742554EBI-456371,EBI-456291 MINT-6540206 I2D: score=5 STRING: ENSP00000274255
    SKP1P632082, 3, ENSP000002314874MINT-6540206 I2D: score=2 STRING: ENSP00000231487
    CDKN1BP465273, ENSP000002288724I2D: score=4 STRING: ENSP00000228872
    DUSP1P285623, ENSP000002392234I2D: score=4 STRING: ENSP00000239223
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS8601310
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007049cell cycle ----
    GO:0008283cell proliferation TAS2227411

    CKS1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKS1B (CKS1)

    1 DrugBank Compound for CKS1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Meta Vanadate-- --target--17139284 17016423 10592235

    2 Novoseek inferred chemical compound relationships for CKS1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 2 10997903 (1), 15513912 (1)
    hydrogen 0 5 16979657 (3)



    CKS1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CKS1B gene: 
    NM_001826.2  

    Unigene Cluster for CKS1B:

    CDC28 protein kinase regulatory subunit 1B
    Hs.374378  [show with all ESTs]
    Unigene Representative Sequence: AK307066
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368439(uc001fgb.3 uc001fga.3) ENST00000368436 ENST00000308987
    ENST00000477676 ENST00000474215 ENST00000473344 ENST00000471245
    miRNA
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    Block miRNA regulation of human, mouse, rat CKS1B using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CKS1B:
    hsa-miR-3163 hsa-miR-548am hsa-miR-548x hsa-miR-494 hsa-miR-330-3p hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidCKS1B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CKS1B
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    GenScript: all cDNA clones in your preferred vector: CKS1B (NM_001826)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKS1B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CKS1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKS1B
      QuantiTect SYBR Green Assays in human, mouse, rat CKS1B
      QuantiFast Probe-based Assays in human, mouse, rat CKS1B

    Additional mRNA sequence: 

    AF274941.1 AF274943.1 AF279897.1 AK307066.1 AK311769.1 BC007751.2 BC015629.2 BC070319.1 
    BC070320.1 BT007196.1 NR_024163.1 X54941.1 

    Selected DOTS entries (see all 31):

    DT.100758287  DT.100877493  DT.100030472  DT.95338231  DT.100877487  DT.419199  DT.121413700  DT.121414021 
    DT.121271065  DT.100877492  DT.100645204  DT.121413968  DT.102839391  DT.120847463  DT.121413873  DT.100030473 
    DT.120636603  DT.92447011  DT.102839395  DT.121413832  DT.101962975  DT.121284720  DT.95338270  DT.100877489 

    Selected AceView cDNA sequences (see all 403):

    BG825309 BM768074 BU620513 BU631579 CB161621 BQ883992 BM836947 BI862096 
    CR607335 BM806391 BC007751 BE220698 BQ891926 CB127050 BF038517 CB160430 
    AI457100 BP430365 CA420091 BM796229 BQ775783 CF127384 BM827960 CA421981 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CKS1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAAGCCT
    CKS1B Expression
    About this image


    CKS1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    CKS1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKS1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374378
        Pathway & Disease-focused RT2 Profiler PCR Array including CKS1B: 
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CKS1B
    OriGene qSTAR qPCR primer pairs in human, mouse for CKS1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKS1B
    QuantiTect SYBR Green Assays in human, mouse, rat CKS1B
    QuantiFast Probe-based Assays in human, mouse, rat CKS1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKS1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CKS1B gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cks1b1 , 5 CDC28 protein kinase 1b1, 5 93.25(n)1
    100(a)1
      3 (39.11 cM)5
    541241  NM_016904.11  NP_058600.11 
     894154725 
    chicken
    (Gallus gallus)
    Aves CKS1B1 CDC28 protein kinase regulatory subunit 1B 81.01(n)
    97.47(a)
      100134845  NM_001112806.1  NP_001106277.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    95(a)
    1 → many
    GL344009.1(58670-62240)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31902 Xenopus laevis transcribed sequence with moderate similarity more 82.56(n)    BJ092992.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cks1b1 CDC28 protein kinase regulatory subunit 1B 79.73(n)
    93.24(a)
      445199  NM_001003593.2  NP_001003593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cks85A1 Cyclin-dependent kinase subunit 85A 67.61(n)
    71.83(a)
      41034  NM_141560.4  NP_649817.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cks-11 cks-1 65.8(n)
    63.64(a)
      177658  NM_069056.6  NP_501457.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CKS1(YBR135W)4 Cyclin-dependent protein kinase regulatory subunit more   --   2(504854-505306) 852432  NP_009693.1 


    ENSEMBL Gene Tree for CKS1B (if available)
    TreeFam Gene Tree for CKS1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CKS1B gene
    CKS22  CKS1BP32  
    1 SIMAP similar gene for CKS1B using alignment to 5 protein entries:     CKS1_HUMAN (see all proteins):
    CKS2

    CKS1B for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CKS1B
    PGOHUM00000242825 PGOHUM00000248262 PGOHUM00000249403 PGOHUM00000250067


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CKS1B (see all 46)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429946791,2
    --154948968(+) AGAACC/TCGATG 2 -- int10--------
    rs1161264621,2
    F--154949067(+) ACATCT/CGAACT 2 -- int11Minor allele frequency- C:0.01NA 120
    rs1464165251,2
    --154949126(+) AAGGAA/TTCACC 2 -- int10--------
    rs1147413851,2
    F--154949218(+) ATTTCG/ATGCCA 2 -- int11Minor allele frequency- A:0.02WA 118
    rs1407740661,2
    C--154949371(+) AGTTTC/GATTCA 2 -- int10--------
    rs1431851351,2
    --154949434(+) AAGCAC/TGGAAT 2 -- int10--------
    rs729973651,2
    C,F--154949515(+) TTTTTA/CAGAGA 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1466832011,2
    --154949644(+) ACTCTA/GTCGCC 2 -- int10--------
    rs1843473961,2
    --154949674(+) ACCTCC/TGCCTC 2 -- int10--------
    rs1887866841,2
    --154949779(+) AGAGAA/CGGGGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for CKS1B (154947118 - 154951725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CKS1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509502CNV Insertion20534489
    nsv872454CNV Loss21882294
    nsv872453CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CKS1B
    DNA2.0 Custom Variant and Variant Library Synthesis for CKS1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116900    OMIM disorders: --

    Selected diseases for CKS1B (see all 29):    
    About MalaCards
    myxofibrosarcoma    paracoccidioidomycosis    mantle cell lymphoma    oral squamous cell carcinoma
    cholesteatoma    hepatoblastoma    multiple myeloma    basal cell carcinoma
    squamous cell carcinoma    intrahepatic cholangiocarcinoma    esophageal squamous cell carcinoma    cholangiocarcinoma
    endometrial carcinoma    myeloma    renal cell carcinoma    adenoma
    esophagitis    hepatocellular carcinoma    lung cancer    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for CKS1B:
    Multiple myeloma

    CKS1B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CKS1B gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aggressiveness 48.3 1 16168119 (1)
    carcinoma medullary 46.2 1 15897741 (1)
    carcinoma 22.8 4 15897741 (1)
    carcinoma squamous cell 20.9 3 15579456 (2), 16080511 (1)
    tumors 20.3 19 18498131 (4), 16168119 (3), 19360356 (3), 17377499 (2) (see all 11)
    colorectal carcinoma 16.3 6 15717322 (5), 15073847 (1)
    cancer 14.5 8 18922157 (3), 19296297 (2), 16168119 (1), 12670508 (1) (see all 5)
    hyperplasia 10.1 1 16882606 (1)
    adenoma 2.78 1 15897741 (1)
    adenocarcinoma 0 2 12670508 (1)

    Genetic Association Database (GAD): CKS1B
    Human Genome Epidemiology (HuGE) Navigator: CKS1B (1 document)

    Export disorders for CKS1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CKS1B gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with CKS1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PubMed id 2227411)1, 2, 3, 9 Richardson H.E.... Reed S.I. (Genes Dev. 1990)
    2. Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. (PubMed id 7791211)1, 2, 9 Arvai A.S.... Tainer J.A. (J. Mol. Biol. 1995)
    3. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. (PubMed id 8601310)1, 2, 9 Bourne Y....Tainer J.A. (Cell 1996)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. (PubMed id 15579456)1, 9 Kitajima S....Takata T. (Am. J. Pathol. 2004)
    7. Expression of cyclin-dependent kinase subunit 1 (Cks1) is regulated during the cell cycle by a CDE/CHR tandem element and is downregulated by p53 but not by p63 or p73. (PubMed id 17377499)1, 9 Rother K....Engeland K. (Cell Cycle 2007)
    8. Three different binding sites of Cks1 are required for p27-ubiquitin ligation. (PubMed id 12140288)1, 9 Sitry D....Hershko A. (J. Biol. Chem. 2002)
    9. Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study. (PubMed id 18922157)1, 9 Liu Z....Ding K. (amp 2008)
    10. CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. (PubMed id 17303695)1, 9 Zhan F....Shaughnessy J.D. (Blood 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1163 HGNC: 19083 AceView: CKS1B Ensembl:ENSG00000173207 euGenes: HUgn1163
    ECgene: CKS1B Kegg: 1163 H-InvDB: CKS1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CKS1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CKS1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CKS1B gene:
    Search GeneIP for patents involving CKS1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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