Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CKMT2 Gene

protein-coding   GIFtS: 66
GCID: GC05P080530

Creatine Kinase, Mitochondrial 2 (Sarcomeric)

  See CKMT2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Creatine Kinase, Mitochondrial 2 (Sarcomeric)1 2     SMTCK2
Basic-Type Mitochondrial Creatine Kinase2 3     Creatine Kinase S-Type, Mitochondrial2
Sarcomeric Mitochondrial Creatine Kinase2 3     mib-CK2
S-MtCK2 3     Mib-CK3
EC 2.7.3.23 8     EC 2.7.38

External Ids:    HGNC: 19961   Entrez Gene: 11602   Ensembl: ENSG000001317307   OMIM: 1232955   UniProtKB: P175403   

Export aliases for CKMT2 gene to outside databases

Previous GC identifers: GC05P079351 GC05P080767 GC05P080567 GC05P080613 GC05P080564 GC05P075738


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CKMT2 Gene:
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to
the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes,
sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two
different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase
isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous
mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among
some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of
these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKMT2 Gene:
CKMT2 (creatine kinase, mitochondrial 2 (sarcomeric)) is a protein-coding gene. Diseases associated with CKMT2 include prostate rhabdomyosarcoma. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot: KCRS_HUMAN, P17540
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKMT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKMT2 gene promoter:
         p53   GATA-3   AP-1   AML1a   Sp1   Lmo2   Nkx2-5   GATA-2   GATA-1   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKMT2 promoter sequence
   Search Chromatin IP Primers for CKMT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKMT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

CKMT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKMT2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P080530:  view genomic region     (about GC identifiers)

Start:
80,529,104 bp from pter      End:
80,562,217 bp from pter
Size:
33,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCRS_HUMAN, P17540 (See protein sequence)
Recommended Name: Creatine kinase S-type, mitochondrial precursor  
Size: 419 amino acids; 47504 Da
Subunit: Exists as an octamer composed of four CKMT2 homodimers
Miscellaneous: Mitochondrial creatine kinase binds cardiolipin
1 PDB 3D structure from and Proteopedia for CKMT2:
2GL6 (3D)    
Secondary accessions: Q6ICS8 Q8N1E1

Explore the universe of human proteins at neXtProt for CKMT2: NX_P17540

Explore proteomics data for CKMT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CKMT2 (P17540) (see all 26)
     CPSNLGT  FADLFDP  NERLGYI  SEVELVQ 


    See CKMT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001093205.1  NP_001093206.1  NP_001816.2  

    ENSEMBL proteins: 
     ENSP00000254035   ENSP00000423264   ENSP00000404203   ENSP00000427635   ENSP00000410289  
    Reactome Protein details: P17540

    CKMT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CKMT2
    OriGene Protein Over-expression Lysate for CKMT2
    OriGene MassSpec for CKMT2
    OriGene Custom Protein Services for CKMT2
    GenScript Custom Purified and Recombinant Proteins Services for CKMT2
    Novus Biologicals CKMT2 Proteins
    Novus Biologicals CKMT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CKMT2
    Cloud-Clone Corp. Proteins for CKMT2

     
    Search eBioscience for Proteins for CKMT2 

     
    antibodies-online proteins for CKMT2 (9 products) 

     
    antibodies-online peptides for CKMT2

    CKMT2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CKMT2
    OriGene Custom Antibody Services for CKMT2
    Novus Biologicals CKMT2 Antibodies
    Abcam antibodies for CKMT2
    Cloud-Clone Corp. Antibodies for CKMT2
    ThermoFisher Antibody for CKMT2
    antibodies-online antibodies for CKMT2 (65 products) 

    CKMT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CKMT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CKMT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CKMT2
    Cloud-Clone Corp. CLIAs for CKMT2
    Search eBioscience for ELISAs for CKMT2 
    antibodies-online kits for CKMT2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P17540

    ProtoNet protein and cluster: P17540

    1 Blocks protein domain: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRS_HUMAN, P17540
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    Find genes that share domains with CKMT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRS_HUMAN, P17540
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
    phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
    fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Genatlas biochemistry entry for CKMT2:
    creatine kinase,mitochondrial 2 (sarcomeric)

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with CKMT2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ckmt2):
     cardiovascular system  growth/size/body  muscle 

    Find genes that share phenotypes with CKMT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ckmt2tm1Bew for CKMT2

       genOway: Develop your customized and physiologically relevant rodent model for CKMT2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CKMT2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CKMT2:
    hsa-miR-634 hsa-miR-3166
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CKMT2
    Predesigned siRNA for gene silencing in human, mouse, rat CKMT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CKMT2

    Clone
    Products:
         
    OriGene clones in human, mouse for CKMT2 (see all 20)
    OriGene ORF clones in mouse, rat for CKMT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CKMT2 (NM_001099735)
    Sino Biological Human cDNA Clone for CKMT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKMT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKMT2
    Addgene plasmids for CKMT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CKMT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CKMT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKMT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KCRS_HUMAN, P17540: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--

    Find genes that share ontologies with CKMT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CKMT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Creatine metabolism0.00
    creatine-phosphate biosynthesis0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Arginine and proline metabolism
    Arginine and proline metabolism


    Find genes that share SuperPaths with CKMT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CKMT2
        creatine-phosphate biosynthesis


    1 Reactome Pathway for CKMT2
        Creatine metabolism


    2 Kegg Pathways  (Kegg details for CKMT2):
        Arginine and proline metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CKMT2
    Interactions:

        Search GeneGlobe Interaction Network for CKMT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CKMT2 (P175402, 3 ENSP000002540354) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OLFML3Q9NRN52, 3MINT-63516 I2D: score=5 
    UNC119Q134322, 3MINT-63515 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-63517 I2D: score=4 
    PSMD4P550363I2D: score=1 
    RIF1Q5UIP03I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process TAS--
    GO:0006936muscle contraction TAS2324105
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with CKMT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKMT2 (KCRS)

    4 HMDB Compounds for CKMT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    PhosphocreatineCreatine phosphate (see all 15)67-07-2--

    1 DrugBank Compound for CKMT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Creatine(alpha-Methylguanido)acetic acid (see all 6)57-00-1targetligand8399219 10567223 17139284 17016423 9642223 1731757

    5 Novoseek inferred chemical compound relationships for CKMT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiolipin 72.9 3 11768757 (1), 15044463 (1)
    creatinine 69.6 48 10462222 (4), 9312135 (2), 17935690 (2), 8276398 (2) (see all 21)
    peroxynitrite 37.7 7 12401781 (3), 9642223 (1)
    atp 28.1 3 10462222 (1), 11154064 (1)
    phospholipid 14.9 2 11154064 (1), 15044463 (1)



    Find genes that share compounds with CKMT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CKMT2 gene (3 alternative transcripts): 
    NM_001099735.1  NM_001099736.1  NM_001825.2  

    Unigene Cluster for CKMT2:

    Creatine kinase, mitochondrial 2 (sarcomeric)
    Hs.80691  [show with all ESTs]
    Unigene Representative Sequence: NM_001825
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254035(uc003khd.4) ENST00000511719 ENST00000513094 ENST00000515615
    ENST00000424301(uc003khc.4) ENST00000505060 ENST00000515238 ENST00000505704
    ENST00000505135 ENST00000514086 ENST00000505850 ENST00000437669(uc010jaq.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CKMT2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CKMT2:
    hsa-miR-634 hsa-miR-3166
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CKMT2
    Predesigned siRNA for gene silencing in human, mouse, rat CKMT2
    Clone
    Products:
         
    OriGene clones in human, mouse for CKMT2 (see all 20)
    OriGene ORF clones in mouse, rat for CKMT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CKMT2 (NM_001099735)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKMT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKMT2
    Addgene plasmids for CKMT2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CKMT2
    OriGene qSTAR qPCR primer pairs in human, mouse for CKMT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKMT2
      QuantiTect SYBR Green Assays in human, mouse, rat CKMT2
      QuantiFast Probe-based Assays in human, mouse, rat CKMT2

    Additional mRNA sequence: 

    AK122769.1 AK130230.1 AK313293.1 BC029140.1 CR450315.1 J05401.1 

    10 DOTS entries:

    DT.91663486  DT.116185  DT.40117024  DT.100759472  DT.97810100  DT.100776056  DT.91796976  DT.86852820 
    DT.95322980  DT.95368579 

    Selected AceView cDNA sequences (see all 102):

    F31576 CB046401 AK130230 W31846 AW243349 BX500049 F26207 AA634512 
    F27266 BC029140 AJ709067 CR450315 AK122769 AI052385 BI835512 AI266454 
    BE463697 AW300490 AA179145 AA972407 BX103414 BI047257 AJ711094 AA176557 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CKMT2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -                       -                                             
    SP2:              -           -                       -                                             
    SP3:              -           -     -                 -                                             
    SP4:              -           -                       -                                             
    SP5:              -           -                                                                     


    ECgene alternative splicing isoforms for CKMT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CKMT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAATGAGC
    CKMT2 Expression
    About this image

    CKMT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKMT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80691

    UniProtKB/Swiss-Prot: KCRS_HUMAN, P17540
    Tissue specificity: Sarcomere-specific. Found only in heart and skeletal muscles

        Custom PCR Arrays for CKMT2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CKMT2
    OriGene qSTAR qPCR primer pairs in human, mouse for CKMT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKMT2
    QuantiTect SYBR Green Assays in human, mouse, rat CKMT2
    QuantiFast Probe-based Assays in human, mouse, rat CKMT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKMT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CKMT2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckmt21 , 5 creatine kinase, mitochondrial 21, 5 88.86(n)1
    95.94(a)1
      13 (47.43 cM)5
    767221  NM_198415.21  NP_940807.11 
     918533875 
    chicken
    (Gallus gallus)
    Aves CKMT21 creatine kinase, mitochondrial 2 (sarcomeric) 78.12(n)
    87.11(a)
      396508  NM_001167744.1  NP_001161216.1 
    lizard
    (Anolis carolinensis)
    Reptilia CKMT26
    creatine kinase, mitochondrial 2 (sarcomeric)
    86(a)
    1 ↔ 1
    2(17440355-17478109)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730592 hypothetical protein MGC73059 78.65(n)   393670  BC059437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51443 arginine kinase 40(a)
    (best of 3)
      66F2   --
    worm
    (Caenorhabditis elegans)
    Secernentea F32B5.13 phosphotransferase 39(a)
    (best of 4)
      I(2700421-2702083)   --


    ENSEMBL Gene Tree for CKMT2 (if available)
    TreeFam Gene Tree for CKMT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CKMT2 gene
    CKB2  CKM2  CKMT1B2  CKMT1A2  
    4 SIMAP similar genes for CKMT2 using alignment to 3 protein entries:     KCRS_HUMAN (see all proteins):
    CKM    CKMT1A    CKMT1B    CKB

    Find genes that share paralogs with CKMT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CKMT2 (see all 118)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467945611,2
    --80527195(+) TTCTAC/TGAAGT 3 -- us2k10--------
    rs1122452141,2
    F--80527324(+) GGAACC/GCAGGT 3 -- us2k12Minor allele frequency- G:0.05CSA WA 119
    rs37769801,2
    C,F,H--80527477(+) TGATAT/CGGCAG 3 -- us2k131Minor allele frequency- C:0.17NS EA NA WA CSA 3082
    rs1841752711,2
    --80527610(+) TGACAA/GGGATG 3 -- us2k10--------
    rs1489208001,2
    --80527670(+) TAGAGA/CTTTCA 3 -- us2k10--------
    rs1437300661,2
    C--80527757(+) ACAATA/GACCCA 3 -- us2k10--------
    rs771069371,2
    F--80527864(+) AATTGG/CGGAGG 3 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1875289501,2
    --80528093(+) TGGGTC/GTTGAC 3 -- us2k10--------
    rs47038271,2
    C,F,H--80528135(+) GTCCCA/CATCTT 3 -- us2k118Minor allele frequency- C:0.17NS EA WA NA CSA 2220
    rs1157072381,2
    C,F--80528255(+) GGGTCG/ATGTTT 3 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for CKMT2 (80529104 - 80562217 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CKMT2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CKMT2
    DNA2.0 Custom Variant and Variant Library Synthesis for CKMT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123295    OMIM disorders: --

    1 disease for CKMT2:    
    About MalaCards
    prostate rhabdomyosarcoma

    2 diseases from the University of Copenhagen DISEASES database for CKMT2:
    Myocardial infarction     Prostate rhabdomyosarcoma

    Find genes that share disorders with CKMT2           About GenesLikeMe

    1 Novoseek inferred disease relationship for CKMT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitochondrial myopathies 57.3 3 11317279 (1), 7808456 (1)

    Genetic Association Database (GAD): CKMT2
    Human Genome Epidemiology (HuGE) Navigator: CKMT2 (1 document)

    Export disorders for CKMT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CKMT2 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with CKMT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes. (PubMed id 2324105)1, 2, 3 Haas R.C. and Strauss A.W. (J. Biol. Chem. 1990)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. (PubMed id 2914937)1, 2 Haas R.C....Strauss A.W. (J. Biol. Chem. 1989)
    5. Elements regulating cardiomyocyte expression of the human sarcomeric mitochondrial creatine kinase gene in transgenic mice. (PubMed id 9312135)1, 9 Qin W....Strauss A.W. (J. Biol. Chem. 1997)
    6. Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues. (PubMed id 12401781)1, 9 Wendt S....Wallimann T. (J. Biol. Chem. 2003)
    7. C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase. (PubMed id 15044463)1, 9 Schlattner U....Wallimann T. (J. Biol. Chem. 2004)
    8. Oxidative myocytes of heart and skeletal muscle express abundant sarcomeric mitochondrial creatine kinase. (PubMed id 10462222)1, 9 Qin W....Strauss A.W. (Histochem. J. 1999)
    9. Expression of the mitochondrial creatine kinase genes. (PubMed id 7808456)1, 9 Payne R.M. and Strauss A.W. (Mol. Cell. Biochem. 1994)
    10. The gene for creatine kinase, mitochondrial 2 (sarcomeric; CKMT2), maps to chromosome 5q13.3. (PubMed id 8276398)1, 9 Richard I....Beckmann J.S. (Genomics 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1160 HGNC: 1996 AceView: CKMT2 Ensembl:ENSG00000131730 euGenes: HUgn1160
    ECgene: CKMT2 Kegg: 1160 H-InvDB: CKMT2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CKMT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CKMT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CKMT2 gene:
    Search GeneIP for patents involving CKMT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CKMT2   OriGene RNAi products in human, mouse, rat for CKMT2  
     OriGene qPCR primer pairs and template standards for CKMT2   OriGene Protein Over-expression Lysate for CKMT2  
     OriGene MassSpec for CKMT2   OriGene clones in human, mouse for CKMT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CKMT2   OriGene Purified Protein for CKMT2  
     OriGene ORF clones in mouse, rat for CKMT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CKMT2   OriGene Custom Protein Services for CKMT2  

     
     
     Block miRNA regulation of human, mouse, rat CKMT2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CKMT2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKMT2 Predesigned siRNA for gene silencing in human, mouse, rat CKMT2
     QuantiFast Probe-based Assays in human, mouse, rat CKMT2 QuantiTect SYBR Green Assays in human, mouse, rat CKMT2
     Custom PCR Arrays for CKMT2 Search Chromatin IP Primers for CKMT2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKMT2  Search GeneGlobe Interaction Network for CKMT2
     Regulatory tfbs in CKMT2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CKMT2 GenScript cDNA clones with any tag delivered in your preferred vector for CKMT2
     GenScript Custom Assay Services for CKMT2 GenScript Custom overexpressing Cell Line Services for CKMT2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CKMT2 (KCRS)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CKMT2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CKMT2 antibodies
     CKMT2 proteins
     CKMT2 lysates
     Antibodies for CKMT2
     See all of Abcam's Antibodies, Kits and Proteins for CKMT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CKMT2
     Proteins for CKMT2
     Antibodies for CKMT2
     ELISAs for CKMT2
     CLIAs for CKMT2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CKMT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKMT2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CKMT2
     SwitchGear Promoter luciferase reporter plasmids for CKMT2
     ThermoFisher Antibody for CKMT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKMT2
     Browse compounds at ApexBio
     Addgene plasmids for CKMT2
      Search eBioscience for proteins for CKMT2
      Search eBioscience for elisas for CKMT2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CKMT2
     antibodies-online antibodies for CKMT2 (65 products)
     antibodies-online kits for CKMT2 (7 products)
     antibodies-online peptides for CKMT2
     antibodies-online proteins for CKMT2 (9 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CKMT2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4