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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKMT1B Gene

protein-coding   GIFtS: 58
GCID: GC15P043885

Creatine Kinase, Mitochondrial 1B

(Previous names: creatine kinase, mitochondrial 1 (ubiquitous))
(Previous symbols: CKMT, CKMT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Creatine Kinase, Mitochondrial 1B1 2     EC 2.7.3.23 8
CKMT1 2 3     UMTCK2
CKMT11 2 5     Creatine Kinase U-Type, Mitochondrial2
Creatine Kinase, Mitochondrial 1 (Ubiquitous)1 2     mia-CK2
Acidic-Type Mitochondrial Creatine Kinase2 3     Mia-CK3
Ubiquitous Mitochondrial Creatine Kinase2 3     EC 2.7.38
U-MtCK2 3     

External Ids:    HGNC: 19951   Entrez Gene: 11592   Ensembl: ENSG000002372897   OMIM: 1232905   UniProtKB: P125323   

Export aliases for CKMT1B gene to outside databases

Previous GC identifers: GC15P041674 GC15P020720


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKMT1B Gene:
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to
the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes,
sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two
different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase
isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial
creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.
Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial
creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical
mitochondrial creatine kinase proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKMT1B Gene: 
CKMT1B (creatine kinase, mitochondrial 1B) is a protein-coding gene. Diseases associated with CKMT1B include prostate rhabdomyosarcoma, and prostate cancer, progression of, and among its related super-pathways are Metabolism and Creatine metabolism. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKMT1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKMT1B gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CKMT1B promoter sequence
   Search SABiosciences Chromatin IP Primers for CKMT1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKMT1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15

CKMT1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKMT1B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P043885:  view genomic region     (about GC identifiers)

Start:
43,885,252 bp from pter      End:
43,897,099 bp from pter
Size:
11,848 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532 (See protein sequence)
Recommended Name: Creatine kinase U-type, mitochondrial precursor  
Size: 417 amino acids; 47037 Da
Subunit: Exists as an octamer composed of four MTCK homodimers
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
Miscellaneous: Mitochondrial creatine kinase binds cardiolipin
1 PDB 3D structure from and Proteopedia for CKMT1B:
1QK1 (3D)    
Secondary accessions: B4DIT8 B7ZA09 Q0VAM3 Q32NF6 Q53FC4
Alternative splicing: 2 isoforms:  P12532-1   P12532-2   

Explore the universe of human proteins at neXtProt for CKMT1B: NX_P12532

Explore proteomics data for CKMT1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12532

  • 4/30 DME Specific Peptides for CKMT1B (P12532) (see all 30)
     CPSNLGT  YARLCDK  AGDEETY  FADLFDP 

    CKMT1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CKMT1B Protein Expression
    REFSEQ proteins: NP_066270.1  
    ENSEMBL proteins: 
     ENSP00000413999   ENSP00000391990   ENSP00000416467   ENSP00000396707   ENSP00000413255  
     ENSP00000411531   ENSP00000416717   ENSP00000399467   ENSP00000300283   ENSP00000389267  
     ENSP00000390428  
    Reactome Protein details: P12532
    Human Recombinant Protein Products for CKMT1B: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CKMT1B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane ----

    CKMT1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000749 ATP-guanido_PTrfase
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P12532

    ProtoNet protein and cluster: P12532

    1 Blocks protein domain: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    CKMT1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRU_HUMAN, P12532
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
    phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
    fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity ----
    GO:0005524ATP binding ----
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    CKMT1B for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ckmt1):
     behavior/neurological  digestive/alimentary  growth/size  hearing/vestibular/ear  homeostasis/metabolism 
     integument  nervous system  reproductive system 

    CKMT1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ckmt1tm2Bew for CKMT1B

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CKMT1B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2creatine-phosphate biosynthesis
    creatine-phosphate biosynthesis0.38
    3Arginine and proline metabolism
    Arginine and proline metabolism0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CKMT1B
        creatine-phosphate biosynthesis

    3        Reactome Pathways for CKMT1B
        Creatine metabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for CKMT1B):
        Arginine and proline metabolism
    Metabolic pathways


    CKMT1B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CKMT1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/49 Interacting proteins for CKMT1B (P125322, 3 ENSP000003002834) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SLC25A5P051412, 3, ENSP000003606714MINT-4054731 I2D: score=1 STRING: ENSP00000360671
    VDAC1P217962, 3, ENSP000002653334MINT-4054731 I2D: score=2 STRING: ENSP00000265333
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process ----
    GO:0034641cellular nitrogen compound metabolic process ----
    GO:0044281small molecule metabolic process ----

    CKMT1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CKMT1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKMT1B (KCRU)

    5 Novoseek inferred chemical compound relationships for CKMT1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclocreatine 87.9 1 11745437 (1)
    cardiolipin 70.7 1 11768757 (1)
    creatinine 68.3 51 11874479 (3), 11745437 (2), 16479256 (2), 20302626 (2) (see all 19)
    phosphocreatine 59.7 13 8923416 (3), 12701812 (2)
    atp 30.1 4 11154064 (1), 12701812 (1)

    Search CenterWatch for drugs/clinical trials and news about CKMT1B / KCRU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CKMT1B gene: 
    NM_020990.3  

    Unigene Cluster for CKMT1B:

    Creatine kinase, mitochondrial 1B
    Hs.741420  [show with all ESTs]
    Unigene Representative Sequence: AK094322
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453782 ENST00000437924 ENST00000475589 ENST00000481666 ENST00000449946
    ENST00000417289 ENST00000441322 ENST00000495545 ENST00000498538 ENST00000453733
    ENST00000437534(uc010udv.1 uc010bdj.3 uc010udy.1) ENST00000428981
    ENST00000411560 ENST00000300283(uc001zsc.3 uc010uds.2) ENST00000450086(uc010udw.1)
    ENST00000413657(uc010udt.2 uc010bdi.3 uc010udu.2 uc010udx.2)

    miRNA
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    Additional mRNA sequence: 

    AK094322.1 AK223365.1 AK293685.1 AK293790.1 AK293939.1 AK293961.1 AK294002.1 AK294063.1 
    AK294735.1 AK294908.1 AK295776.1 AK296271.1 AK296472.1 AK308770.1 AK311698.1 AK316124.1 
    AK316319.1 BC001926.1 BC006467.1 BC108652.1 BC121001.1 BC121002.1 

    24/25 DOTS entries (see all 25):

    DT.95261994  DT.315670  DT.100813509  DT.97850558  DT.100805678  DT.100813525  DT.100813526  DT.121025287 
    DT.97833511  DT.40254055  DT.100813514  DT.100813522  DT.121025034  DT.97850542  DT.100813520  DT.121024946 
    DT.121025328  DT.95262005  DT.95261995  DT.121024827  DT.121025341  DT.121025348  DT.97850540  DT.121025027 

    24/346 AceView cDNA sequences (see all 346):

    BE254441 BU539798 CA488871 BC001926 BC006467 AK094322 BE184296 BE795609 
    BE903209 BE794334 BM785596 CR605038 BM743640 BE794868 BE264218 CR618017 
    CR616544 BI820667 BP362822 CR597545 BT006628 AA324707 AA084108 BM818857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKMT1B expression in normal human tissues (normalized intensities)      CKMT1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CKMT1B Expression
    About this image


    CKMT1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             Septum   
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose   

    See CKMT1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKMT1B

    SOURCE GeneReport for Unigene cluster: Hs.741420
        SABiosciences Custom PCR Arrays for CKMT1B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKMT1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CKMT1B gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckmt15 creatine kinase, mitochondrial 1, ubiquitous   --   2 (60.37 cM) 121357714 
    chicken
    (Gallus gallus)
    Aves CKMT1A6
    creatine kinase U-type, mitochondrial precursor
    93(a)
    1 → many
    10(19638558-19641543)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 → many
    GL343759.1(238609-245328)
    African clawed frog
    (Xenopus laevis)
    Amphibia ckmt1-prov2 creatine kinase, mitochondrial 1 (ubiquitous) 77.56(n)    BC045123.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ckmt12 creatine kinase, mitochondrial 1 77.87(n)   321892  BC048050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51446
    CG45466
    (see all 3)
    --
    35(a)
    29(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3L(9040539-9041824)
    3R(11672230-11674158)
    worm
    (Caenorhabditis elegans)
    Secernentea F44G3.26
    F11G11.136
    (see all 6)
    Protein F11G11.13
    (see all 6)
    38(a)
    37(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    V(16103894-16106140)
    II(4875071-4875702)


    ENSEMBL Gene Tree for CKMT1B (if available)
    TreeFam Gene Tree for CKMT1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CKMT1B gene
    CKMT1A1 2  CKB2  CKM2  CKMT22  
    4 SIMAP similar genes for CKMT1B using alignment to 10 protein entries:     KCRU_HUMAN (see all proteins):
    CKMT1A    CKB    CKM    CKMT2

    CKMT1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/149 SNPs in CKMT1B are shown (see all 149)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3758087131,2
    C--20805983(+) CAATCC/TCAGTA 1 -- us2k10--------
    rs2000996911,2
    C--20806005(+) CGAGGC/TGGGCA 1 -- us2k10--------
    rs1512620461,2
    C--20806006(+) GAGGCA/GGGCAG 1 -- us2k10--------
    rs2008990121,2
    C--20806014(+) CAGATC/TGCTGG 1 -- us2k10--------
    rs2008718881,2
    C--20806268(+) CTTAA-/GGTACT 1 -- us2k10--------
    rs24674221,2
    O--20806851(+) CACAAC/GGGATA 1 -- us2k10--------
    rs38094761,2
    C--20807496(-) AGAGTA/TGAAAT 1 -- us2k10--------
    rs38094751,2
    C--20807509(-) GAGAAG/TGAATG 1 -- us2k10--------
    rs38094741,2
    C,F--20807645(-) GAGGTG/CGTCAG 1 -- us2k12Minor allele frequency- C:0.50NA 4
    rs38094731,2
    C--20807664(-) GAGTGG/ATGTAC 1 -- us2k12Minor allele frequency- A:0.00NA 4

    HapMap Linkage Disequilibrium report for CKMT1B (43885252 - 43897099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for CKMT1B (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749626CNV Deletion23290073
    esv2421427CNV Deletion20811451
    nsv509569CNV Insertion20534489
    nsv1514CNV Loss18451855
    dgv2374n71CNV Loss21882294
    dgv2373n71CNV Loss21882294
    nsv428304CNV Loss18775914
    esv33424CNV Loss17666407
    nsv437799CNV Loss16327808
    nsv524910CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123290    OMIM disorders: --

    11 diseases for CKMT1B:    About MalaCards
    prostate rhabdomyosarcoma    prostate cancer, progression of    chronic obstructive pulmonary disease    oral squamous cell carcinoma
    rhabdomyosarcoma    myocardial infarction    prostatitis    prostate cancer
    squamous cell carcinoma    sarcoma    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for CKMT1B:
    Myocardial infarction     Prostate rhabdomyosarcoma

    CKMT1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): CKMT1B
    Human Genome Epidemiology (HuGE) Navigator: CKMT1B (1 document)

    Export disorders for CKMT1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CKMT1B gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with CKMT1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human ubiquitous mitochondrial creatine kinase. (PubMed id 10737943)1, 2, 9 Eder M.... Schlattner U. (2000)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. (PubMed id 2914937)1, 2 Haas R.C....Strauss A.W. (1989)
    6. Regulation of creatine kinase isoenzymes in human placenta during early, mid-, and late gestation. (PubMed id 8923416)1, 9 Thomure M.F....Payne R.M. (1996)
    7. A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance. (PubMed id 11768757)1, 9 Schlattner U. and Wallimann T. (2000)
    8. ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. (PubMed id 20302626)1, 9 Kwon S....Kwon H.J. (2010)
    9. Creatine kinase and creatine transporter in normal, wounded, and diseased skin. (PubMed id 11874479)1, 9 Schlattner U....Wallimann T. (2002)
    10. Expression of the mitochondrial creatine kinase genes. (PubMed id 7808456)1, 9 Payne R.M. and Strauss A.W. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1159 HGNC: 1995 AceView: CKMT1 Ensembl:ENSG00000237289 euGenes: HUgn1159
    ECgene: CKMT1B Kegg: 1159 H-InvDB: CKMT1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CKMT1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CKMT1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CKMT1B gene:
    Search GeneIP for patents involving CKMT1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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