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CKMT1A Gene

protein-coding   GIFtS: 54
GCID: GC15P043985

Creatine Kinase, Mitochondrial 1A

(Previous names: creatine kinase, mitochondrial 1 (ubiquitous))
(Previous symbol: CKMT1)
  See CKMT1A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Creatine Kinase, Mitochondrial 1A1 2     EC 2.7.3.23 8
CKMT11 2     Creatine Kinase U-Type, Mitochondrial2
Creatine Kinase, Mitochondrial 1 (Ubiquitous)1 2     mia-CK2
Acidic-Type Mitochondrial Creatine Kinase2 3     CKMT3
Ubiquitous Mitochondrial Creatine Kinase2 3     Mia-CK3
U-MtCK2 3     EC 2.7.38

External Ids:    HGNC: 317361   Entrez Gene: 5485962   Ensembl: ENSG000002235727   OMIM: 6134155   UniProtKB: P125323   

Export aliases for CKMT1A gene to outside databases

Previous GC identifers: GC15P041773 GC15U900516 GC15P043886 GC15P020808


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CKMT1A Gene:
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to
the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes,
sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two
different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase
isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial
creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.
Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial
creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical
mitochondrial creatine kinase proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKMT1A Gene:
CKMT1A (creatine kinase, mitochondrial 1A) is a protein-coding gene. Diseases associated with CKMT1A include prostate rhabdomyosarcoma. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKMT1A gene promoter:
         E2F-4   E2F-3a   E2F   E2F-1   E2F-2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CKMT1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKMT1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15

CKMT1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKMT1A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P043985:  view genomic region     (about GC identifiers)

Start:
43,985,084 bp from pter      End:
43,991,420 bp from pter
Size:
6,337 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532 (See protein sequence)
Recommended Name: Creatine kinase U-type, mitochondrial precursor  
Size: 417 amino acids; 47037 Da
Subunit: Exists as an octamer composed of four MTCK homodimers
Miscellaneous: Mitochondrial creatine kinase binds cardiolipin
1 PDB 3D structure from and Proteopedia for CKMT1A:
1QK1 (3D)    
Secondary accessions: B4DIT8 B7ZA09 Q0VAM3 Q32NF6 Q53FC4
Alternative splicing: 2 isoforms:  P12532-1   P12532-2   

Explore the universe of human proteins at neXtProt for CKMT1A: NX_P12532

Explore proteomics data for CKMT1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CKMT1A (P12532) (see all 30)
     CPSNLGT  YARLCDK  AGDEETY  FADLFDP 


    See CKMT1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001015001.1  
    ENSEMBL proteins: 
     ENSP00000413165   ENSP00000398973   ENSP00000389806   ENSP00000406577   ENSP00000401927  
    Reactome Protein details: P12532

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P12532

    ProtoNet protein and cluster: P12532

    1 Blocks protein domain: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    Find genes that share domains with CKMT1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRU_HUMAN, P12532
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
    phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
    fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with CKMT1A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKMT1A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCRU_HUMAN, P12532: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    cytoskeleton1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS2914937
    GO:0005743mitochondrial inner membrane TAS--

    Find genes that share ontologies with CKMT1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CKMT1A About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Creatine metabolism0.00
    3Arginine and proline metabolism
    Arginine and proline metabolism


    Find genes that share SuperPaths with CKMT1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CKMT1A
        Creatine metabolism


    2 Kegg Pathways  (Kegg details for CKMT1A):
        Arginine and proline metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CKMT1A
    Interactions:

        Search GeneGlobe Interaction Network for CKMT1A

    Selected Interacting proteins for CKMT1A (P125322, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VDAC1P217962, 3MINT-4054731 I2D: score=2 
    YWHAZP631042, 3MINT-3304487 I2D: score=2 
    SLC25A5P051412, 3MINT-4054731 I2D: score=1 
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with CKMT1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKMT1A (KCRU)

    4 HMDB Compounds for CKMT1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    PhosphocreatineCreatine phosphate (see all 15)67-07-2--

    1 DrugBank Compound for CKMT1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Creatine(alpha-Methylguanido)acetic acid (see all 6)57-00-1targetligand11538605 17139284 8662608 2394753 17016423 1731757



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CKMT1A gene: 
    NM_001015001.1  

    Unigene Cluster for CKMT1A:

    Creatine kinase, mitochondrial 1A
    Hs.654988  [show with all ESTs]
    Unigene Representative Sequence: BT006628
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434505(uc001zsn.3 uc010uea.2) ENST00000411750 ENST00000457648
    ENST00000413453(uc010ueb.1 uc010bdo.2) ENST00000415044 ENST00000483604
    ENST00000479938
    miRNA
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    Products:
         
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      QuantiFast Probe-based Assays in human, mouse, rat CKMT1A

    Additional mRNA sequence: 

    AK316052.1 BT006628.1 

    11 DOTS entries:

    DT.315670  DT.100805678  DT.95261994  DT.97833511  DT.100813514  DT.100813509  DT.100813525  DT.121025328 
    DT.100813520  DT.100813526  DT.92046065 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CKMT1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CKMT1A Expression
    About this image


    CKMT1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)
             Cerebellum
     
     Colon (Gastrointestinal Tract)
    CKMT1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKMT1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654988
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CKMT1A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckmt11 creatine kinase, mitochondrial 1, ubiquitous 92.17(n)
    96.88(a)
      12716  NM_009897.2  NP_034027.1 
    chicken
    (Gallus gallus)
    Aves CKMT1A1 creatine kinase, mitochondrial 1A 77.38(n)
    88.49(a)
      374002  NM_204182.1  NP_989513.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 → many
    GL343759.1(238609-245328)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ckmt1b1 creatine kinase, mitochondrial 1B 73.78(n)
    84.17(a)
      395000  NM_204038.1  NP_989369.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ckmt11 creatine kinase, mitochondrial 1 72.44(n)
    81.49(a)
      321892  NM_198801.1  NP_942096.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51446
    CG45466
    (see all 4)
    --
    37(a)
    29(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3L(9040539-9041824)
    3R(11672230-11674158)
    worm
    (Caenorhabditis elegans)
    Secernentea F46H5.36
    F44G3.26
    (see all 6)
    Protein F44G3.2 (F44G3.2) mRNA, complete cds
    (see all 6)
    39(a)
    38(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    X(7230330-7238662) WBGene00018519
    V(16103894-16106140) WBGene00009706


    ENSEMBL Gene Tree for CKMT1A (if available)
    TreeFam Gene Tree for CKMT1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CKMT1A gene
    CKMT1B1 2  CKB2  CKM2  CKMT22  
    4 SIMAP similar genes for CKMT1A using alignment to 4 protein entries:     KCRU_HUMAN (see all proteins):
    CKMT1B    CKMT2    CKB    CKM

    Find genes that share paralogs with CKMT1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for CKMT1A    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996803511,2
    ----43990913(+) GCTGCC/TACAGG 2 A syn10--------

    HapMap Linkage Disequilibrium report for CKMT1A (43985084 - 43991420 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CKMT1A (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749626CNV Deletion23290073
    esv2421427CNV Deletion20811451
    nsv1514CNV Loss18451855
    esv33424CNV Loss17666407
    nsv437799CNV Loss16327808
    nsv428304CNV Loss18775914
    dgv2371n71CNV Gain21882294
    dgv2375n71CNV Gain21882294
    dgv2372n71CNV Gain21882294
    nsv9254CNV Gain+Loss18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613415    OMIM disorders: --

    1 disease for CKMT1A:    
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    prostate rhabdomyosarcoma

    2 diseases from the University of Copenhagen DISEASES database for CKMT1A:
    Myocardial infarction     Prostate rhabdomyosarcoma

    Find genes that share disorders with CKMT1A           About GenesLikeMe

    Genetic Association Database (GAD): CKMT1A
    Human Genome Epidemiology (HuGE) Navigator: CKMT1A (1 document)

    Export disorders for CKMT1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CKMT1A gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CKMT1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human ubiquitous mitochondrial creatine kinase. (PubMed id 10737943)1, 2, 9 Eder M.... Schlattner U. (Proteins 2000)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. (PubMed id 2914937)1, 2 Haas R.C....Strauss A.W. (J. Biol. Chem. 1989)
    5. Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression. (PubMed id 19415690)1, 9 Pang B....Zhou J.G. (Prostate 2009)
    6. ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. (PubMed id 20302626)1, 9 Kwon S....Kwon H.J. (BMC Biol. 2010)
    7. Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues. (PubMed id 12401781)1, 9 Wendt S....Wallimann T. (J. Biol. Chem. 2003)
    8. Reconstitution of CKMT1 expression fails to rescue cells from mitochondrial membrane potential dissipation: implications for controlling RNAi experiments. (PubMed id 23880370)1 Datler C. and Grimm S. (Biochim. Biophys. Acta 2013)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 548596 HGNC: 31736 Ensembl:ENSG00000223572 euGenes: HUgn548596 ECgene: CKMT1A Kegg: 548596
    H-InvDB: CKMT1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CKMT1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CKMT1A gene:
    Search GeneIP for patents involving CKMT1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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