Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CKMT1A Gene

Aliases for CKMT1A Gene

  • Creatine Kinase, Mitochondrial 1A 2 3
  • Creatine Kinase, Mitochondrial 1 (Ubiquitous) 2 3
  • Acidic-Type Mitochondrial Creatine Kinase 3 4
  • Ubiquitous Mitochondrial Creatine Kinase 3 4
  • EC 2.7.3.2 4 64
  • Mia-CK 3 4
  • U-MtCK 3 4
  • Creatine Kinase U-Type, Mitochondrial 3
  • CKMT1A CKMT1B 4
  • EC 2.7.3 64
  • CKMT1 3
  • CKMT 4

External Ids for CKMT1A Gene

Previous Symbols for CKMT1A Gene

  • CKMT1

Summaries for CKMT1A Gene

Entrez Gene Summary for CKMT1A Gene

  • Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKMT1A Gene

CKMT1A (Creatine Kinase, Mitochondrial 1A) is a Protein Coding gene. Diseases associated with CKMT1A include prostate rhabdomyosarcoma. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot for CKMT1A Gene

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKMT1A Gene

Genomics for CKMT1A Gene

Genomic Location for CKMT1A Gene

Start:
43,692,886 bp from pter
End:
43,699,222 bp from pter
Size:
6,337 bases
Orientation:
Plus strand

Genomic View for CKMT1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKMT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKMT1A Gene

Regulatory Elements for CKMT1A Gene

Proteins for CKMT1A Gene

  • Protein details for CKMT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12532-KCRU_HUMAN
    Recommended name:
    Creatine kinase U-type, mitochondrial
    Protein Accession:
    P12532
    Secondary Accessions:
    • B4DIT8
    • B7ZA09
    • Q0VAM3
    • Q32NF6
    • Q53FC4

    Protein attributes for CKMT1A Gene

    Size:
    417 amino acids
    Molecular mass:
    47037 Da
    Quaternary structure:
    • Exists as an octamer composed of four MTCK homodimers.
    Miscellaneous:
    • Mitochondrial creatine kinase binds cardiolipin

    Three dimensional structures from OCA and Proteopedia for CKMT1A Gene

    Alternative splice isoforms for CKMT1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKMT1A Gene

Proteomics data for CKMT1A Gene at MOPED

Post-translational modifications for CKMT1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CKMT1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CKMT1A Gene

UniProtKB/Swiss-Prot:

KCRU_HUMAN
Domain:
  • Contains 1 phosphagen kinase C-terminal domain.:
    • P12532
  • Contains 1 phosphagen kinase N-terminal domain.:
    • P12532
Family:
  • Belongs to the ATP:guanido phosphotransferase family.:
    • P12532
genes like me logo Genes that share domains with CKMT1A: view

No data available for Gene Families for CKMT1A Gene

Function for CKMT1A Gene

Molecular function for CKMT1A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + creatine = ADP + phosphocreatine.
UniProtKB/Swiss-Prot Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Enzyme Numbers (IUBMB) for CKMT1A Gene

Gene Ontology (GO) - Molecular Function for CKMT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004111 creatine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CKMT1A: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CKMT1A Gene

Localization for CKMT1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKMT1A Gene

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKMT1A Gene COMPARTMENTS Subcellular localization image for CKMT1A gene
Compartment Confidence
mitochondrion 5
cytosol 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CKMT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 2914937
GO:0005743 mitochondrial inner membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CKMT1A: view

Pathways for CKMT1A Gene

genes like me logo Genes that share pathways with CKMT1A: view

Pathways by source for CKMT1A Gene

Gene Ontology (GO) - Biological Process for CKMT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006600 creatine metabolic process TAS --
GO:0016310 phosphorylation IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CKMT1A: view

Compounds for CKMT1A Gene

(4) HMDB Compounds for CKMT1A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Creatine
  • ((amino(imino)methyl)(methyl)amino)acetate
57-00-1
Phosphocreatine
  • Creatine phosphate
67-07-2

(1) Drugbank Compounds for CKMT1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Creatine
  • (alpha-Methylguanido)acetic acid
57-00-1 target ligand
genes like me logo Genes that share compounds with CKMT1A: view

Transcripts for CKMT1A Gene

mRNA/cDNA for CKMT1A Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CKMT1A Gene

Creatine kinase, mitochondrial 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKMT1A Gene

No ASD Table

Relevant External Links for CKMT1A Gene

GeneLoc Exon Structure for
CKMT1A
ECgene alternative splicing isoforms for
CKMT1A

Expression for CKMT1A Gene

mRNA expression in normal human tissues for CKMT1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKMT1A Gene

This gene is overexpressed in Brain - Cerebellum (4.7), Brain - Cerebellar Hemisphere (4.6), and Colon - Transverse (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKMT1A Gene

SOURCE GeneReport for Unigene cluster for CKMT1A Gene Hs.654988

genes like me logo Genes that share expressions with CKMT1A: view

Orthologs for CKMT1A Gene

This gene was present in the common ancestor of animals.

Orthologs for CKMT1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
LOC100608872 36
  • 99.6 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CKMT1 37
  • 98 (a)
OneToMany
CKMT1B 36
  • 92.96 (n)
  • 98.3 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 98 (a)
OneToMany
CKMT1B 36
  • 94.16 (n)
  • 98.32 (a)
mouse
(Mus musculus)
Mammalia Ckmt1 36
  • 92.17 (n)
  • 96.88 (a)
Ckmt1 37
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ckmt1b 36
  • 91.85 (n)
  • 96.88 (a)
chicken
(Gallus gallus)
Aves CKMT1A 36
  • 77.38 (n)
  • 88.49 (a)
CKMT1A 37
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ckmt1b 36
  • 73.78 (n)
  • 84.17 (a)
zebrafish
(Danio rerio)
Actinopterygii ckmt1 36
  • 72.44 (n)
  • 81.49 (a)
ckmt1 37
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Argk 37
  • 27 (a)
ManyToMany
CG30274 37
  • 20 (a)
ManyToMany
CG4546 37
  • 29 (a)
ManyToMany
CG5144 37
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F11G11.13 37
  • 36 (a)
ManyToMany
F32B5.1 37
  • 34 (a)
ManyToMany
F44G3.2 37
  • 38 (a)
ManyToMany
F46H5.3 37
  • 39 (a)
ManyToMany
W10C8.5 37
  • 37 (a)
ManyToMany
ZC434.8 37
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
CSA.4059 37
  • 64 (a)
ManyToMany
Species with no ortholog for CKMT1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKMT1A Gene

ENSEMBL:
Gene Tree for CKMT1A (if available)
TreeFam:
Gene Tree for CKMT1A (if available)

Paralogs for CKMT1A Gene

Paralogs for CKMT1A Gene

Selected SIMAP similar genes for CKMT1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CKMT1A: view

Variants for CKMT1A Gene

Sequence variations from dbSNP and Humsavar for CKMT1A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2236740 -- 43,697,989(+) TTTTC(A/G/T)TTAAT intron-variant
rs2259950 -- 43,696,377(-) CTACA(C/T)AATCT intron-variant
rs2259951 -- 43,696,375(-) ACACA(A/G)TCTTC intron-variant
rs2411268 -- 43,696,498(-) GTCCT(A/G)GAGTG intron-variant
rs2411269 -- 43,696,484(-) CCTAG(A/G)TAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CKMT1A Gene

Variant ID Type Subtype PubMed ID
nsv437799 CNV Loss 16327808
nsv428304 CNV Loss 18775914
dgv741e1 CNV Complex 17122850
dgv742e1 CNV Complex 17122850
dgv2371n71 CNV Gain 21882294
dgv2372n71 CNV Gain 21882294
esv24113 CNV Gain+Loss 19812545
nsv1514 CNV Loss 18451855
esv2421427 CNV Deletion 20811451
esv33424 CNV Loss 17666407
dgv743e1 CNV Complex 17122850
esv2749626 CNV Deletion 23290073
dgv2375n71 CNV Gain 21882294
nsv9254 CNV Gain+Loss 18304495

Relevant External Links for CKMT1A Gene

HapMap Linkage Disequilibrium report
CKMT1A

Disorders for CKMT1A Gene

(1) MalaCards Diseases for CKMT1A Gene

Search for CKMT1A Gene in MalaCards »

(2) University of Copenhagen DISEASES for CKMT1A Gene

Relevant External Links for CKMT1A

Genetic Association Database (GAD)
CKMT1A
Human Genome Epidemiology (HuGE) Navigator
CKMT1A
genes like me logo Genes that share disorders with CKMT1A: view

No data available for UniProtKB/Swiss-Prot for CKMT1A Gene

Publications for CKMT1A Gene

  1. Crystal structure of human ubiquitous mitochondrial creatine kinase. (PMID: 10737943) Eder M. … Schlattner U. (Proteins 2000) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. (PMID: 2914937) Haas R.C. … Strauss A.W. (J. Biol. Chem. 1989) 3 4
  4. Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues. (PMID: 12401781) Wendt S. … Wallimann T. (J. Biol. Chem. 2003) 3 23
  5. Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression. (PMID: 19415690) Pang B. … Zhou J.G. (Prostate 2009) 3 23

Products for CKMT1A Gene

Sources for CKMT1A Gene

Back to Top

Content