Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKM Gene

protein-coding   GIFtS: 69
GCID: GC19M045809

Creatine Kinase, Muscle


(Previous symbol: CKMM)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Creatine Kinase, Muscle1 2     EC 2.7.3.23 8
CKMM1 2 3 5     Creatine Kinase M-Type2
Creatine Kinase M Chain2 3     EC 2.7.38
M-CK2 3     

External Ids:    HGNC: 19941   Entrez Gene: 11582   Ensembl: ENSG000001048797   OMIM: 1233105   UniProtKB: P067323   

Export aliases for CKM gene to outside databases

Previous GC identifers: GC19M046454 GC19M046200 GC19M050485 GC19M050501 GC19M042241


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKM Gene:
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum
marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP
and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other
tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the
ATP:guanido phosphotransferase protein family. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKM Gene: 
CKM (creatine kinase, muscle) is a protein-coding gene. Diseases associated with CKM include subvalvular aortic stenosis, and mcleod syndrome, and among its related super-pathways are Metabolic pathways and Creatine metabolism. GO annotations related to this gene include creatine kinase activity and ATP binding. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKM gene promoter:
         USF1   USF-1   MyoD   Pax-4a   Arnt   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKM promoter sequence
   Search SABiosciences Chromatin IP Primers for CKM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

CKM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKM gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M045809:  view genomic region     (about GC identifiers)

Start:
45,809,671 bp from pter      End:
45,826,235 bp from pter
Size:
16,565 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732 (See protein sequence)
Recommended Name: Creatine kinase M-type  
Size: 381 amino acids; 43101 Da
Subunit: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and
myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for CKM:
1I0E (3D)    
Secondary accessions: Q96QL9

Explore the universe of human proteins at neXtProt for CKM: NX_P06732

Explore proteomics data for CKM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06732

  • 4/26 DME Specific Peptides for CKM (P06732) (see all 26)
     CPSNLGT  NEEDHLR  GGDDLDP  AGDEESY 

    CKM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CKM Protein Expression
    REFSEQ proteins: NP_001815.2  
    ENSEMBL proteins: 
     ENSP00000221476  
    Reactome Protein details: P06732
    Human Recombinant Protein Products for CKM: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CKM
    OriGene Protein Over-expression Lysate for CKM
    OriGene MassSpec for CKM 
    OriGene Custom Protein Services for CKM
    GenScript Custom Purified and Recombinant Proteins Services for CKM
    Novus Biologicals CKM Proteins
    Novus Biologicals CKM Lysates
    Sino Biological Recombinant Protein for CKM
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CKM
    Cloud-Clone Corp. Proteins for CKM 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--

    CKM for ontologies           About GeneDecksing



    CKM Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CKM (Creatine Kinase, Muscle/CKMM)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CKM
    GenScript Superior Antibodies for CKM
    Novus Biologicals CKM Antibodies
    Abcam antibodies for CKM
    Cloud-Clone Corp. Antibodies for CKM 
    ThermoFisher Antibodies for CKM
    LSBio Antibodies in human, mouse, rat for CKM 

    Assay Products for CKM: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CKM
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CKM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CKM 
    Cloud-Clone Corp. CLIAs for CKM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000749 ATP-guanido_PTrfase
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P06732

    ProtoNet protein and cluster: P06732

    1 Blocks protein domain: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    CKM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRM_HUMAN, P06732
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
    phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
    fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Genatlas biochemistry entry for CKM:
    creatine kinase,muscle

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    CKM for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CKM:
     Increased viability after born 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ckm):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  muscle 

    CKM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CKM: Ckmtm1Bew Ckmtm2Bew

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CKM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CKM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKM 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKM
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CKM:
    hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
    SwitchGear 3'UTR luciferase reporter plasmidCKM 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CKM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CKM
    Sirion Biotech Customized adenovirus for overexpression of CKM

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CKM (see all 8)
    OriGene ORF clones in mouse, rat for CKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
    Sino Biological Human cDNA Clone for CKM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM
    Sirion Biotech Customized lentivirus for stable overexpression of CKM 
                         Customized lentivirus expression plasmids for stable overexpression of CKM 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CKM
    Search LifeMap BioReagents cell lines for CKM
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CKM About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2creatine-phosphate biosynthesis
    creatine-phosphate biosynthesis0.38
    Creatine metabolism0.38
    3Arginine and proline metabolism
    Arginine and proline metabolism0.35
    Urea cycle and metabolism of amino groups0.35
    4Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CKM
        AMPK Enzyme Complex Pathway

    3 BioSystems Pathways for CKM
        creatine-phosphate biosynthesis
    Regulation of retinoblastoma protein
    Urea cycle and metabolism of amino groups


    3        Reactome Pathways for CKM
        Creatine metabolism
    Metabolism
    Metabolism of amino acids and derivatives

    1 PharmGKB Pathway for CKM
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics

    2         Kegg Pathways  (Kegg details for CKM):
        Arginine and proline metabolism
    Metabolic pathways


    CKM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CKM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for CKM (P067323 ENSP000002214764) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q13, ENSP000003633904I2D: score=2 STRING: ENSP00000363390
    CKBP122773, ENSP000002991984I2D: score=1 STRING: ENSP00000299198
    TRIM54Q9BYV23, ENSP000002960984I2D: score=1 STRING: ENSP00000296098
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MYOM2P542963, ENSP000002621134I2D: score=1 STRING: ENSP00000262113
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046314phosphocreatine biosynthetic process IEA--

    CKM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CKM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKM (KCRM)

    4 HMDB Compounds for CKM    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    PhosphocreatineCreatine phosphate (see all 15)67-07-2--

    4 DrugBank Compounds for CKM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (Diaminomethyl-Methyl-Amino)-Acetic Acid-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Creatine(alpha-Methylguanido)acetic acid (see all 6)57-00-1targetligand17000714 1731757 17389266
    D-Arginine-- 157-06-2target--17139284 17016423 10592235

    10/23 Novoseek inferred chemical compound relationships for CKM gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 84.5 273 19327508 (5), 9808283 (5), 1690725 (3), 9756613 (3) (see all 99)
    phosphocreatine 39.7 2 18979206 (1)
    glycogen 18.9 5 18560415 (2), 15922959 (1)
    percoll 14.9 1 8833742 (1)
    atp 12 4 9516180 (1), 1950416 (1), 18979206 (1)
    pyruvate 9.82 1 9740064 (1)
    chloramphenicol 5.5 1 1690725 (1)
    calcium 3.94 1 15389566 (1)
    oxygen 0 1 11708401 (1)
    nitric oxide 0 1 8617220 (1)

    Search CenterWatch for drugs/clinical trials and news about CKM / KCRM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CKM gene: 
    NM_001824.4  

    Unigene Cluster for CKM:

    Creatine kinase, muscle
    Hs.334347  [show with all ESTs]
    Unigene Representative Sequence: NM_001824
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000221476(uc002pbd.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKM
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CKM:
    hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
    SwitchGear 3'UTR luciferase reporter plasmidCKM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CKM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKM
    Clone
    Products:
         
    OriGene clones in human, mouse for CKM (see all 8)
    OriGene ORF clones in mouse, rat for CKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM
    Sirion Biotech Customized lentivirus for stable overexpression of CKM 
                         Customized lentivirus expression plasmids for stable overexpression of CKM 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CKM
    OriGene qSTAR qPCR primer pairs in human, mouse for CKM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CKM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKM

    Additional mRNA sequence: 

    AK129878.1 AK300730.1 AK313281.1 BC007462.1 BT006793.1 M14780.1 M16440.1 

    16 DOTS entries:

    DT.86999432  DT.91755914  DT.100820874  DT.121502341  DT.102828559  DT.100820873  DT.121502345  DT.100820875 
    DT.121502338  DT.91755923  DT.100820876  DT.100820872  DT.100820877  DT.87000155  DT.95369564  DT.100031850 

    24/987 AceView cDNA sequences (see all 987):

    BP334221 F31933 F18053 F29376 F30387 F20425 F31171 F31444 
    CA398119 F22796 AJ572902 F29239 F30182 F30046 F30805 AA295833 
    F29176 F16746 F15513 F33674 F33305 F30227 AJ573041 CD612932 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CKM    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                                                                          
    SP2:                          -     -     -     -     -     -     -                           
    SP3:                                -     -                                                   
    SP4:              -                                                                           


    ECgene alternative splicing isoforms for CKM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKM expression in normal human tissues (normalized intensities)      CKM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCCCGCCC
    CKM Expression
    About this image


    CKM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             heart muscle ; myocytes   
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             skeletal muscle ; myocytes   
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Blood (Muscoskeletal System)    fully expand to see all 2 entries
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
             mouse/organ system/cardiovascular system   

    See CKM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKM

    SOURCE GeneReport for Unigene cluster: Hs.334347
        SABiosciences Expression via Pathway-Focused PCR Array including CKM: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CKM
    OriGene qSTAR qPCR primer pairs in human, mouse for CKM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CKM
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKM
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CKM gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckm1 , 5 creatine kinase, muscle1, 5 90.29(n)1
    96.59(a)1
      7 (9.67 cM)5
    127151  NM_007710.21  NP_031736.11 
     194110945 
    chicken
    (Gallus gallus)
    Aves CKM1 creatine kinase, muscle 81.45(n)
    90.29(a)
      396507  NM_205507.1  NP_990838.1 
    lizard
    (Anolis carolinensis)
    Reptilia CKM6
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL344965.1(1198-12130)
    African clawed frog
    (Xenopus laevis)
    Amphibia ckm-prov2 creatine kinase, muscle 80.36(n)    BC042249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ckm2 creatine kinase, muscle 82.81(n)   30095  BC056706.1 


    ENSEMBL Gene Tree for CKM (if available)
    TreeFam Gene Tree for CKM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CKM gene
    CKB2  CKMT1B2  CKMT22  CKMT1A2  
    4 SIMAP similar genes for CKM using alignment to 1 protein entry:     KCRM_HUMAN:
    CKB    CKMT2    CKMT1B    CKMT1A

    CKM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    359/535 SNPs in CKM are shown (see all 535)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81119891,2
    C,F,A,H--45809208(+) AGCCAT/CGGCAG 1 -- int129Minor allele frequency- C:0.34NS EA NA WA CSA 3084
    rs178756311,2
    C,F--45809265(-) GTCCCG/ATCTGA 1 -- int12Minor allele frequency- A:0.01NS 80
    rs1896109641,2
    --45809333(+) CTCAAA/CACTGG 1 -- int10--------
    rs178756301,2
    C,F--45809344(-) CCCAAC/TGGTCT 1 -- int14Minor allele frequency- T:0.07NS WA 200
    rs1816688081,2
    --45809554(+) AACTTA/TGCCTC 1 -- int10--------
    rs1118437491,2
    C--45809672(+) AAGCTT/AAGGCC 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs753793651,2
    F--45809685(+) CAATGC/TTTTTA 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1861891121,2
    --45809697(+) TTATCA/GCTTTG 1 -- ut310--------
    rs178756291,2
    C,F,H--45809750(-) TCTAGT/CTAATG 1 -- ut31 ese314Minor allele frequency- C:0.03NS NA WA 1526
    rs178756281,2
    C,F--45809886(-) CTCTCT/CCCACC 1 -- ut31 ese34Minor allele frequency- C:0.05NS WA 210
    rs81881,2
    C,F--45809912(-) CCCTGT/GCCCAG 1 -- ut31 ese31Minor allele frequency- G:0.01MN 184
    rs1171722201,2
    C,F--45809940(+) GGGAGC/TAGGAC 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs2021466591,2
    --45809988(+) CAGTCA/GGTGGC 1 -- ut310--------
    rs1420924401,2
    C,F--45810010(+) CGCCTA/GCTTCT 2 Q * stop-lost2Minor allele frequency- G:0.00NA EU 5875
    rs48841,2
    C,F,A,H--45810035(-) TCCATC/TGACGA 2 I syn152Minor allele frequency- T:0.31MN NS EA CSA EU CSAM NA WA 10448
    rs760720921,2
    C--45810075(+) CCACCA/C/GTGAGC 3 T R M mis11NA 2
    rs1999139391,2
    C--45810108(+) GCACCT/CGTTCT 2 /Q /R mis11Minor allele frequency- C:0.00EU 1323
    rs2017331221,2
    --45810149(+) GACACA/GTCAAA 2 D syn10--------
    rs1128054831,2
    C--45810332(+) TCATTC/AGTGAG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1820369881,2
    --45810617(+) CCTTGA/CCGGAT 1 -- int10--------
    rs2005710891,2
    --45810715(+) GAGCCA/GTACCT 1 -- int10--------
    rs1130882241,2
    C--45810716(+) AGCCGA/C/TACCTG 1 -- int11CSA 1
    rs1852678911,2
    C--45810773(+) GGGGTA/GCTTGC 2 H Y mis10--------
    rs1502719121,2
    C,F--45810791(+) CGCCAG/CCTTCA 2 /L /V mis12Minor allele frequency- C:0.00NA EU 5757
    rs2016972021,2
    --45810850(+) GCACGC/TAGCCC 2 Y C mis10--------
    rs2006337591,2
    C--45810862(+) GGTGCC/TGGTTC 2 Q R mis10--------
    rs1115977341,2
    C--45810911(+) AATCTG/TAGGTT 1 -- int10--------
    rs81048501,2
    C,F,H--45810943(+) GCGCCG/AGCAGG 1 -- int111Minor allele frequency- A:0.05NS EA NA CSA 1096
    rs1491877861,2
    C--45810966(+) CACCCA/GCAACA 1 -- int10--------
    rs1912062271,2
    --45811017(+) AGGTGA/GGATTC 1 -- int10--------
    rs1825739751,2
    --45811080(+) ACCAAA/GGCAGG 1 -- int10--------
    rs347298311,2
    C--45811124(+) GCGGGT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1468563141,2
    --45811270(+) GCGCGC/TGCCAC 1 -- int10--------
    rs3447951,2
    C,F--45811305(+) attaaT/Gttttt 1 -- int13Minor allele frequency- G:0.02NS WA 208
    rs178756261,2
    C,F--45811507(-) CCCCCC/-AAAAC 1 -- int14Minor allele frequency- -:0.19NS NA 92
    rs1129786621,2
    C--45811664(+) ACACCA/C/GACCTT 1 -- int11CSA 1
    rs1127343551,2
    C--45811666(+) ACCCAC/TCTTCT 1 -- spd10--------
    rs1493544591,2
    C,F--45811692(+) AGCGGC/GGGAAA 2 P R mis12Minor allele frequency- G:0.00NA EU 5875
    rs178756251,2,4
    C--45811716(-) GAAGGG/CGGGCA 2 /A /G mis1 trp33Minor allele frequency- C:0.01NS NA 90
    rs3447941,2
    C,F,H--45812101(+) CTTGGA/TAATCC 1 -- int118Minor allele frequency- T:0.01NS EA NA WA CSA 767
    rs1880907121,2
    --45812217(+) GCGGTG/TGCTCA 1 -- int10--------
    rs1481852271,2
    --45812287(+) GACACA/CATCCT 1 -- int10--------
    rs129762431,2
    C,F--45812354(+) GGTGGC/TGGGCA 1 -- int18Minor allele frequency- T:0.25NS NA CSA 88
    rs1912447861,2
    --45812472(+) CAGAGC/TGAGAC 1 -- int10--------
    rs1827835611,2
    --45812650(+) ATCTAC/GAAAAT 1 -- int10--------
    rs1874720051,2
    --45812706(+) CCACTA/GGGGAG 1 -- int10--------
    rs1503170351,2
    C--45812719(+) TGAGGA/CGGGAG 1 -- int10--------
    rs1924293511,2
    --45812736(+) TTGACC/TTTGGA 1 -- int10--------
    rs1848732251,2
    --45812800(+) CAGAGA/CAAGAC 1 -- int10--------
    rs1887940411,2
    --45812917(+) GAGTTC/GGAGAC 1 -- int10--------
    rs1925591601,2
    --45812918(+) AGTTCA/GAGACC 1 -- int10--------
    rs1379997291,2
    --45812965(+) AAATAC/TGAAAA 1 -- int10--------
    rs1425482401,2
    --45813401(+) TGAGAC/TAGAGT 1 -- int10--------
    rs1844123601,2
    --45813503(+) CCTCAC/TGAGTA 1 -- int10--------
    rs1897442221,2
    --45813602(+) CTCGAA/TCTCCT 1 -- int10--------
    rs178756221,2
    C,F--45813629(-) AGGCCA/GAGGCG 1 -- int13Minor allele frequency- G:0.04NS NA 94
    rs178756211,2
    C,F--45813630(-) GAGGCC/TAAGGC 1 -- int13Minor allele frequency- T:0.04NS NA 94
    rs1813988151,2
    --45813669(+) CACCGC/TGCCTG 1 -- int10--------
    rs1844818351,2
    C--45813763(+) CCCTAC/TCCTAT 1 -- int10--------
    rs1418085781,2
    --45813823(+) AAAGCA/TAGTAA 1 -- int10--------
    rs23773261,2
    C,F,A--45813830(+) gtaaaG/Tttagt 1 -- int14Minor allele frequency- T:0.50NA WA 8
    rs2009166571,2
    --45813830(+) GTAAA-/GTTAGT 1 -- int10--------
    rs3447931,2
    C,A--45813831(+) taaagC/Ttagta 1 -- int111Minor allele frequency- T:0.39WA NA CSA EA 372
    rs81096161,2
    C,F--45813923(+) tacctC/Tggtca 1 -- int14Minor allele frequency- T:0.10NS CSA WA 200
    rs178756201,2
    C,F--45813969(-) GGCTGA/TGGATC 1 -- int13Minor allele frequency- T:0.02NS WA 82
    rs1819101131,2
    --45814002(+) GTATAA/CGCCAT 1 -- int10--------
    rs30475581,2
    C--45814018(+) TTTTT-/TTTT  
            
    GAGAC
    1 -- int11Minor allele frequency- TTTT:0.00NA 2
    rs556744701,2
    C--45814055(+) GAGACA/GGAGTC 1 -- int10--------
    rs711731451,2
    C--45814196(+) TTTTTT/-GTAGT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs118801751,2
    C,H--45814213(+) ttttgG/Tagttt 1 -- int10--------
    rs713522601,2
    C,F--45814221(+) TTTTAG/ATAGAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs118801791,2
    C,H--45814256(+) gatggG/Tgtcaa 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1112733221,2
    C,F--45814281(+) GATCCG/ACCCAC 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1919861981,2
    --45814362(+) GTAGCA/GACGTG 1 -- int10--------
    rs1506388801,2
    C--45814364(+) AGCGAA/CGTGGT 1 -- int10--------
    rs1807267211,2
    --45814413(+) ACAAGC/TGACCC 1 -- int10--------
    rs1166892121,2
    --45814487(+) AAGTTC/TTTTCT 1 -- int10--------
    rs1408672821,2
    --45814709(+) AAACTC/GCTGAC 1 -- int10--------
    rs1860377211,2
    --45814730(+) CCCCCC/GGCCTT 1 -- int10--------
    rs1120161071,2
    C,F--45814741(+) GGCCTC/TGCAAA 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs72604631,2
    C,F,A,H--45814860(+) GGCAGG/TGGCGG 1 -- int122Minor allele frequency- T:0.34NS EA WA NA CSA 2418
    rs178756181,2
    C,F--45814864(-) CCCTCC/TGCCCC 1 -- int13Minor allele frequency- T:0.03NS WA 194
    rs72603591,2
    C,F,A,H--45814908(+) AATTAT/CGTATA 1 -- int128Minor allele frequency- C:0.48NS EA NA WA CSA 2612
    rs178756171,2
    C,F--45814947(-) GCAACG/AGCCCT 1 -- int16Minor allele frequency- A:0.09NS CSA WA NA 321
    rs178756161,2
    C,F--45815033(-) GCCCGC/AGACTG 2 /R syn1 ese39Minor allele frequency- A:0.07NS NA CSA WA EU 4426
    rs2017055521,2
    --45815092(+) GTGGTC/GATCGA 2 H D mis10--------
    rs2012843281,2
    --45815120(+) TTCTCC/GGTCAT 2 T syn10--------
    rs1413226571,2
    C--45815145(+) AGTACT/GTCCCT 2 /K /T mis11Minor allele frequency- G:0.00NA 4550
    rs1508027821,2
    C,F--45815159(+) AACTCA/C/GCCCGT 3 G syn11NA 4550
    rs173571221,2,4
    C,F,H--45815163(+) CGCCCG/ATCAGG 2 /T /M mis1 ese315Minor allele frequency- A:0.01NA NS EA EU 7133
    rs2003897051,2
    --45815195(+) CACGAC/GGGAGT 1 -- int10--------
    rs104027471,2
    C,F,A--45815248(+) GGGTTT/CCCCCT 1 -- int115Minor allele frequency- C:0.48NS WA NA CSA EA 1098
    rs1417705311,2
    --45815284(+) CTTGGC/TCCCCT 1 -- int10--------
    rs1456350181,2
    --45815296(+) GATGTC/GCTAAA 1 -- int10--------
    rs1454210861,2
    --45815568(+) GGTAGC/TCAGGT 1 -- int10--------
    rs1913364431,2
    C--45815572(+) GCCAGA/GTGCAC 1 -- int10--------
    rs178756541,2
    C,F--45815575(-) CCAGTG/ACACCT 1 -- int14Minor allele frequency- A:0.02NS NA 88
    rs1118777831,2
    C--45815645(+) GTTCG-/AGAGTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1434663491,2
    --45815714(+) TTGCTC/GTTGTT 1 -- int10--------
    rs1480062501,2
    --45815733(+) TGGAGC/TGCAAT 1 -- int10--------
    rs1408542971,2
    --45815738(+) CGCAAA/TGGCGC 1 -- int10--------
    rs1125244091,2
    C,F--45815767(+) CCTCCA/GTCTCC 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1132659571,2
    C,F--45815783(+) TCAAGC/TGAATC 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1157634301,2
    C,F--45815784(+) CAAGCG/TAATCT 1 -- int11Minor allele frequency- T:0.08WA 118
    rs1858576921,2
    --45815796(+) TTGCCG/TCAGCC 1 -- int10--------
    rs118788151,2
    C,F,H--45815824(+) tacagG/Acatgc 1 -- int15Minor allele frequency- A:0.50NA WA 12
    rs1903172931,2
    --45815878(+) TTTCTC/TCACTT 1 -- int10--------
    rs1829222631,2
    --45815975(+) GGGAGA/GCCAAG 1 -- int10--------
    rs1417694301,2
    --45816084(+) GCACAC/TGCCTG 1 -- int10--------
    rs104082671,2
    C,H--45816125(+) gagaaT/Acactt 1 -- int15Minor allele frequency- A:0.00NA CSA 9
    rs1381092491,2
    --45816268(+) AAATAA/TGTGTA 1 -- int10--------
    rs178756141,2
    C,F--45816452(-) GCTGTA/CGGAAA 1 -- int12Minor allele frequency- C:0.02NS 86
    rs1889229801,2
    --45816454(+) TCCTAC/TAGCAT 1 -- int10--------
    rs1931239841,2
    --45816466(+) TGCCAC/TTTCGT 1 -- int10--------
    rs178756131,2
    C,F--45816470(-) AGACAC/GGAAGT 1 -- int12Minor allele frequency- G:0.05NS 86
    rs1407248951,2
    C--45816483(+) GTGTCA/GCATGT 1 -- int10--------
    rs1827526681,2
    --45816497(+) TAATTC/GTCACA 1 -- int10--------
    rs118789181,2
    C,F,H--45816529(+) ttactA/Gtatct 1 -- int18Minor allele frequency- G:0.08NA NS CSA WA 336
    rs6397831,2
    C,F,A,H--45816547(-) atcacG/Agatcg 1 -- int117Minor allele frequency- A:0.26NS EA NA WA CSA 1394
    rs1446896041,2
    C--45816684(+) CTCCCC/TATCTC 1 -- int10--------
    rs1474898521,2
    --45816695(+) CTTGAA/GCCTCC 1 -- int10--------
    rs1400576381,2
    --45816765(+) GCCTCA/GAGGTG 1 -- int10--------
    rs1877239651,2
    --45816937(+) CCGATC/TCTACT 1 -- int10--------
    rs1429399381,2
    --45816950(+) AAATAC/GAAAAA 1 -- int10--------
    rs1917588831,2
    --45817083(+) TGGGCA/GACAAG 1 -- int10--------
    rs730410021,2
    C,F--45817208(+) AAGCCC/TAGGAG 1 -- int12Minor allele frequency- T:0.07NA 122
    rs730427031,2
    C,F--45817395(+) AGGGAG/AGGAAG 1 -- int12Minor allele frequency- A:0.07NA 122
    rs2004233231,2
    --45817399(+) GGGAA-/GGGAAG 1 -- int10--------
    rs1406729311,2
    C--45817433(+) AAGGA-/AAGG  
            
    AAGGA
    1 -- int10--------
    rs2002633401,2
    --45817456(+) GGAAG-/GAAT  
            
    TGCCG
    1 -- int10--------
    rs768768391,2
    C,F--45817491(+) ACAACC/TGCCCT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1511134831,2
    --45817631(+) CTAGAC/TATAAT 1 -- int10--------
    rs1411216281,2
    --45817645(+) ATTGTA/GCACTT 1 -- int10--------
    rs43892341,2
    C,F--45817724(+) tggagG/Tgcagt 1 -- int14Minor allele frequency- T:0.43NA WA CSA 7
    rs1132777641,2
    C--45817732(+) AGTGGC/TGTGAT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1843294801,2
    --45817750(+) CACTGC/TAACCT 1 -- int10--------
    rs1886787091,2
    --45817894(+) CTCAAA/GCTCCT 1 -- int10--------
    rs1408164871,2
    C--45818063(+) CTCCCA/GGGCTC 1 -- int10--------
    rs1446450901,2
    --45818117(+) GGTGTA/GTGCCA 1 -- int10--------
    rs5602051,2
    C,F--45818144(+) TTTGTC/ATTTTT 1 -- int19Minor allele frequency- A:0.21NA WA EA 254
    rs48038131,2
    C,F,A--45818526(+) CCGTCG/AAGTCT 1 -- int112Minor allele frequency- A:0.26NS WA NA 946
    rs3647551,2
    C,F,A--45818527(+) CGTCGG/AGTCTG 1 -- int115Minor allele frequency- A:0.25EA NA MN NS WA CSA 663
    rs3650651,2
    C,F--45818581(+) CCCGCG/ACCATT 1 -- int19Minor allele frequency- A:0.17MN NS WA NA CSA 518
    rs3779931,2
    C,F,A--45818628(+) CTTTGA/GAAAGC 1 -- int122Minor allele frequency- G:0.26EA NS NA WA CSA 2596
    rs1919861631,2
    --45818635(+) AAGCGG/TGGGCC 1 -- int10--------
    rs777845311,2
    C--45818662(+) CCTGCC/TCATGG 1 -- int10--------
    rs1995497131,2
    --45818705(+) GTGGAC/GGGGGT 1 -- int10--------
    rs1905193101,2
    C--45818746(+) CCACCA/GCCCGG 2 A V mis10--------
    rs1467055161,2
    C--45818749(+) CCGCCC/TGGCGC 2 Q R mis10--------
    rs1498720151,2
    C--45818750(+) CGCCCG/AGCGCT 2 /R /W mis11Minor allele frequency- A:0.00NA 4404
    rs1475741451,2
    C--45818809(+) CAGTGC/TGGACG 2 H R mis11Minor allele frequency- T:0.00NA 4532
    rs178756531,2,4
    C,F--45818825(-) ACGTGC/GTCAGC 2 L V mis1 ese35Minor allele frequency- G:0.00NS NA EU 5585
    rs11331901,2
    C,F,O,A,H--45818835(-) GACCCT/CAACTA 2 /P syn1 ese329Minor allele frequency- C:0.44EA NS MN NA WA CSA EU 9631
    rs3751799351,2
    C--45818864(+) GAGAGA/C/TGGGTG 1 -- int10--------
    rs2007720871,2
    --45818865(+) AGAGCA/GGGTGG 1 -- int10--------
    rs1860205311,2
    --45819113(+) TTTTTC/TTTCTT 1 -- int10--------
    rs561539451,2
    C--45819115(+) TTTTTTTTTTTT 
     TTTTT
    /-
    CTTCG
    1 -- cds11Minor allele frequency- -:0.00NA 2
    rs19673101,2
    C--45819119(+) TTCTTT/CGAGAC 1 -- int1 trp31Minor allele frequency- C:0.00NA 2
    rs1893323561,2
    --45819284(+) AATAAA/GTTTTT 1 -- int10--------
    rs19673111,2
    C,F,A,H--45819307(+) CAGGGG/ACTGGG 1 -- int18Minor allele frequency- A:0.13NS EA NA WA 654
    rs1480352601,2
    --45819354(+) AAGCCA/GAGGTG 1 -- int10--------
    rs133455621,2
    C,F--45819458(+) tggtgC/Tgcgcc 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1808543611,2
    --45819565(+) CCTGGA/GTGACA 1 -- int10--------
    rs3725008001,2
    C--45819672(+) CTGCCC/TAGCCT 1 -- int10--------
    rs1501715811,2
    --45819707(+) ATGAGC/TCACCA 1 -- int10--------
    rs1390103991,2
    --45819791(+) CTGGTA/CGTGAA 1 -- int10--------
    rs1430326451,2
    --45819792(+) TGGTCA/GTGAAC 1 -- int10--------
    rs129847281,2
    C,F,A--45819807(+) ctggcT/Ctcacg 1 -- int112Minor allele frequency- C:0.40NA WA CSA EA 375
    rs1181646061,2
    F--45819809(+) GGCTTC/AACGTG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs2003211451,2
    --45820030(+) CACCC-/TTTTTT 1 -- int10--------
    rs104118621,2
    C,F,A--45820096(+) aacacT/Cagcat 1 -- int114Minor allele frequency- C:0.36NS NA WA CSA EA 452
    rs22386851,2
    C,F--45820126(+) ttttaA/Gtagag 1 -- int18Minor allele frequency- G:0.26NS NA CSA EA 208
    rs178756091,2
    C,F--45820144(-) AACACG/AGTGAA 1 -- int12Minor allele frequency- A:0.06NS 78
    rs178756521,2
    C,F--45820164(-) AGTTCG/AAGACC 1 -- int12Minor allele frequency- A:0.04NS 78
    rs129839351,2
    C,F--45820222(+) acaagC/Ggtgag 1 -- int110Minor allele frequency- G:0.32NS NA WA EA 446
    rs129839441,2
    C,F--45820238(+) gtgccC/GggctA 1 -- int17Minor allele frequency- G:0.14NS NA WA EA 440
    rs1853063411,2
    --45820300(+) CCTTTA/GTCTGT 1 -- int10--------
    rs1901713151,2
    --45820353(+) CTCTCC/TGTCCC 1 -- int10--------
    rs2015869031,2
    --45820369(+) TTTCC-/TTTTTT 1 -- int10--------
    rs72517481,2
    C,F,A--45820377(+) tttttA/Tttttc 1 -- int18Minor allele frequency- T:0.38NA WA CSA EA 367
    rs129714331,2
    C,F--45820540(+) tatttT/Aattta 1 -- int18Minor allele frequency- A:0.35NS NA WA CSA 89
    rs1827865421,2
    --45820561(+) TATTTA/TTTGAG 1 -- int10--------
    rs1443124221,2
    C--45820575(+) AGTTTC/TGCCCT 1 -- int10--------
    rs178756061,2
    C,F--45820608(-) AGATCG/ATGCCA 1 -- int12Minor allele frequency- A:0.01NS 78
    rs1424383981,2
    --45820615(+) ATCTCA/TGCTCA 1 -- int10--------
    rs1868964131,2
    --45820649(+) CAAGCA/GATTCT 1 -- int10--------
    rs1127235081,2
    C,F--45820717(+) ATTCTG/CTATTT 1 -- int12Minor allele frequency- C:0.50NA CSA 4
    rs72523881,2
    C,F--45820733(+) agagaC/Tggggt 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1115961561,2
    C,F--45820737(+) ACGGGA/GTTTCA 1 -- int12Minor allele frequency- G:0.33NA CSA 3
    rs1113518241,2
    C,F--45820742(+) GTTTCT/ACCATG 1 -- int13Minor allele frequency- A:0.40NA CSA 5
    rs1922321381,2
    --45820770(+) AAACTC/TTCAAT 1 -- int10--------
    rs1840743101,2
    --45820838(+) CCGCCA/GTGCCC 1 -- int10--------
    rs129769561,2
    C,F,A--45820927(+) CGCTCG/ACCTCA 1 -- int110Minor allele frequency- A:0.33NS NA CSA WA EA 462
    rs1127338191,2
    C--45821080(+) ACACCA/C/GACCTT 1 -- int11CSA 1
    rs1116229151,2
    C--45821081(+) CACCGA/C/TCCTTG 1 -- spd11CSA 1
    rs178756041,2
    C,F,H--45821095(-) AACCAT/CGAAAA 2 /H syn16Minor allele frequency- C:0.00NS NA WA 4992
    rs115590241,2,4
    C,F,H--45821183(-) CTACGA/GAGTTT 2 E G mis1 ese310Minor allele frequency- G:0.02NS NA EU 6729
    rs2001705741,2
    --45821184(+) AACTTC/TGTAGG 2 K E mis10--------
    rs115590231,2
    C,F--45821215(-) ACCGTA/G/TGGCTG 3 V syn11NA 4550
    rs1912297141,2
    C--45821248(+) GGGGTA/GGGGGT 1 -- int10--------
    rs1823204111,2
    C,F--45821257(+) GTGAGG/ATCAGA 1 -- int11Minor allele frequency- A:0.01EU 1237
    rs803019951,2
    F--45821331(+) GTGTCG/AGGATG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1401482811,2
    --45821342(+) GGGGCA/GGGTAC 1 -- int10--------
    rs4329791,2
    C,F,H--45821691(+) GAGAAC/GACTGA 1 -- int115Minor allele frequency- G:0.21EA NA NS WA CSA 827
    rs1870356831,2
    --45821781(+) GCTGGC/GGGCGG 1 -- int10--------
    rs178756501,2
    C,F--45821784(-) ACCCCG/ACCCCC 1 -- int13Minor allele frequency- A:0.01NS NA 88
    rs1918463221,2
    --45821856(+) ATTAGC/TACCCA 1 -- int10--------
    rs1490921911,2
    --45821992(+) GGGGCC/TTCTCC 1 -- int10--------
    rs124600221,2
    C,F,H--45821999(+) CTCCCC/TGGCAT 1 -- int18Minor allele frequency- T:0.07NA NS CSA WA EA 450
    rs178756491,2
    C,F--45822048(-) GGGAGT/CGGAGG 1 -- int13Minor allele frequency- C:0.01NS NA 88
    rs1851918641,2
    --45822063(+) CTCTTC/TGCCTT 1 -- int10--------
    rs1126764321,2
    C--45822122(+) GATTC-/TTTTTT 1 -- int11Minor allele frequency- T:0.00CSA 2
    rs1389611501,2
    --45822226(+) TCCCAC/TCGCAG 1 -- int10--------
    rs572880571,2
    C,F--45822264(+) CTCATC/TACCAC 1 -- int12Minor allele frequency- T:0.10WA EA 238
    rs349068231,2
    C--45822684(+) GAGGCC/-CCCCC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1118995611,2
    F--45822688(+) GGCCCG/CCCCCC 1 -- int11Minor allele frequency- C:0.50CSA 4
    rs6359211,2
    C,F--45822701(-) ACCACC/TCTTGA 1 -- int14Minor allele frequency- T:0.03NS NA WA 98
    rs6358981,2
    C,F,H--45822720(-) CCGGCC/TATGCC 1 -- int112Minor allele frequency- T:0.02NS EA NA WA 1020
    rs1133457151,2
    C--45822776(+) AGGCTG/CACCTG 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs2010481641,2
    C--45822809(+) GACATC/TGTCTA 2 N D mis10--------
    rs2014701051,2
    --45822811(+) CATCGC/TCTACA 2 D G mis10--------
    rs1406514871,2
    C--45822845(+) GTCCCA/C/G/
            
    CAGCT
    4 R G W syn1 mis11NA 4550
    rs1456337721,2
    C,F--45822882(+) TTGGCC/AATGTG 2 /M /I mis11Minor allele frequency- A:0.00NA 4550
    rs1382246181,2
    C,F--45822909(+) AGGTCG/AGGGTA 2 /P syn12Minor allele frequency- A:0.00NA EU 5873
    rs3448201,2
    C,F,H--45823006(+) GGCAGG/AAGGGG 1 -- int1 trp38Minor allele frequency- A:0.02EA NS NA WA 488
    rs1932436931,2
    --45823122(+) CGGCTA/CACTGC 1 -- int10--------
    rs1130528881,2
    F--45823145(+) CTGGGC/TTCACA 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs3448191,2
    C,F,A--45823174(+) ctcccA/Gagtag 1 -- int18Minor allele frequency- G:0.22NS NA WA CSA 95
    rs1893612471,2
    --45823206(+) ACCACA/GCCGGC 1 -- int10--------
    rs1807247471,2
    C--45823263(+) AGGATA/GGTCTT 1 -- int10--------
    rs1837005731,2
    --45823291(+) ATCCGC/GCCGCC 1 -- int10--------
    rs1418702641,2
    C--45823294(+) CGCCCA/GCCTCG 1 -- int10--------
    rs1884678201,2
    --45823375(+) AGTCTC/TACTCT 1 -- int10--------
    rs1137776761,2
    F--45823449(+) AAGAGT/ATTCTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs178756481,2
    C,F--45823490(-) GTGTGC/TGCCTG 1 -- int13Minor allele frequency- T:0.03NS NA 94
    rs3448181,2
    C,F,A--45823663(+) CTCGCA/GTCTTG 1 -- int111Minor allele frequency- G:0.49NS NA WA CSA EA 463
    rs178756471,2
    C--45823681(-) TTCTCT/GTGCTG 1 -- int14Minor allele frequency- G:0.01NS NA 98
    rs1813128641,2
    --45823740(+) AAATCC/TTCTCT 1 -- int10--------
    rs1869431261,2
    --45823754(+) AGCCCA/CTGTGT 1 -- int10--------
    rs1917847001,2
    --45823807(+) TCTGCC/TGTATC 1 -- int10--------
    rs1134821171,2
    C,F--45823885(+) CCTCCA/CGGAGG 1 -- int12Minor allele frequency- C:0.33CSA 3
    rs178756461,2
    C,F,H--45824064(-) CAACAC/TTCCCA 1 -- int113Minor allele frequency- T:0.04NS NA 1462
    rs1819182631,2
    --45824104(+) GCTCTC/TGGAAC 1 -- int10--------
    rs713387671,2
    C--45824148(+) GCTGC-/TAT/TATTAT/TATT
    ATTAT
    /TATTATTATTAT
    TATTA
    4 -- cds11NA 2
    rs763476521,2
    --45824159(+) TTATTT/ATTATT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs3448171,2
    C,F,A,H--45824204(+) cccagG/Actaga 1 -- int17Minor allele frequency- A:0.16NA MN NS WA 462
    rs65092081,2
    C,F,A,H--45824218(+) cagtgG/Acataa 1 -- int15Minor allele frequency- A:0.47NS NA 92
    rs178755921,2
    C,F--45824267(-) GCAGGA/GTAGTT 1 -- int14Minor allele frequency- G:0.04NS CSA 79
    rs357924541,2
    C--45824321(+) GGCTAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1870032801,2
    --45824332(+) TTTTTG/TGGTAT 1 -- int10--------
    rs1910899431,2
    --45824395(+) GAACTC/TAAGTG 1 -- int10--------
    rs178755901,2
    C,F--45824595(-) GCAGCT/CACCCA 1 -- int19Minor allele frequency- C:0.04NS NA CSA WA 334
    rs739421331,2
    C,F--45824668(+) TGGGTC/TGTCAG 1 -- int12Minor allele frequency- T:0.05WA 120
    rs178756451,2
    C,F--45824891(-) AAAAAG/ATAGTA 1 -- int17Minor allele frequency- A:0.06NS NA CSA 214
    rs1466532571,2
    --45824995(+) TATGCA/GTGTGA 1 -- int10--------
    rs178756441,2
    C,F,H--45825020(-) TAACAG/ATAGGA 1 -- int116Minor allele frequency- A:0.05NS NA CSA 1682
    rs1821563461,2
    --45825105(+) GACGGG/TGATGG 1 -- int10--------
    rs1484074481,2
    --45825111(+) GATGGA/GAAGCA 1 -- int10--------
    rs178756431,2
    C--45825183(-) TTTGGC/GGGGTC 1 -- int13Minor allele frequency- G:0.01NS NA 86
    rs1425497971,2
    --45825200(+) GGGTGC/TTGCTG 1 -- int10--------
    rs1509657131,2
    --45825211(+) TCCAGA/GGTGGT 1 -- int10--------
    rs1868981071,2
    C--45825251(+) TCCCAC/TCCCCA 1 -- int10--------
    rs1115717661,2
    F--45825274(+) CCCCAC/TCCCCA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs129816811,2
    C,F--45825414(+) AGAGGA/TTGCCC 1 -- int115Minor allele frequency- T:0.15NS NA EA 1168
    rs1179558731,2
    C,F--45825418(+) GATGCC/TCCCCT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1408221001,2
    --45825439(+) AGGGAA/CACCCC 1 -- int10--------
    rs1444517721,2
    --45825478(+) CCCCCC/GCCACA 1 -- int10--------
    rs104104481,2
    C,F,H--45825480(+) CCCCCC/GACAAG 1 -- int120Minor allele frequency- G:0.44NS EA NA WA CSA 1379
    rs1117259691,2
    F--45825556(+) AAACTG/AAGTCA 1 -- int13Minor allele frequency- A:0.40CSA 5
    rs3448161,2
    C,F,O,A,H--45825626(+) TCAGAA/TACAAG 1 -- int142Minor allele frequency- T:0.49EA NA NS WA CSA 3742
    rs1831729311,2
    --45825659(+) CAAACA/GCAAAG 1 -- int10--------
    rs1886455751,2
    --45825721(+) CCCACA/GGCTTG 1 -- int10--------
    rs1928240331,2
    --45825772(+) TGGCTC/TAACAG 1 -- int10--------
    rs739421341,2
    C,F--45825787(+) TTGCAG/AGGGGT 1 -- int12Minor allele frequency- A:0.02WA 120
    rs1478487711,2
    --45825790(+) CAGGGA/GGTGAC 1 -- int10--------
    rs178756421,2
    C,F--45825826(-) GATCCG/AAGATG 1 -- int16Minor allele frequency- A:0.05NS NA 220
    rs1413872281,2
    --45825858(+) GTGCCA/GCAGAA 1 -- int10--------
    rs1853477621,2
    --45825883(+) TGGGGA/GGTTCA 1 -- int10--------
    rs1470121041,2
    --45825936(+) CAACCC/TTCCCA 1 -- int10--------
    rs178756411,2
    C,F--45825948(-) CAGGTC/TGGTGC 1 -- int15Minor allele frequency- T:0.05NS NA 218
    rs1876437901,2
    --45826037(+) AAATCC/TCCTAC 1 -- int10--------
    rs129745411,2
    H--45826115(+) GTATCC/ATGGAG 1 -- ut51 ese34Minor allele frequency- A:0.00NS EA 412
    rs1113237811,2
    C--45826134(+) GACCCA/C/TAAGGA 2 -- ut511CSA 1
    rs1117708601,2
    C--45826135(+) ACCCAA/C/TAGGAA 2 -- ut511CSA 1
    rs3448151,2
    C,F,A,H--45826254(+) GCTCCC/GGCACC 1 -- us2k111Minor allele frequency- G:0.36MN EA WA NA CSA 725
    rs1926225621,2
    --45826289(+) CTTTGC/TGCCCA 1 -- us2k10--------
    rs118824791,2
    C,F,H--45826366(+) ACCCTG/AACCAA 1 -- us2k112Minor allele frequency- A:0.31NS EA NA WA CSA 663
    rs1835829231,2
    --45826405(+) GCTGGA/CCCCCC 1 -- us2k10--------
    rs1883206881,2
    --45826631(+) AGGCCA/GGGAGA 1 -- us2k10--------
    rs1382580851,2
    --45826680(+) CCCGCA/GCTTGG 1 -- us2k10--------
    rs1435502281,2
    C--45826784(+) CACCC-/TCCCCC 1 -- us2k10--------
    rs1813704221,2
    --45827126(+) AGACTC/TGCGCA 1 -- us2k10--------
    rs178756401,2
    C,F--45827148(-) GAGCGC/ATTGCT 1 -- us2k16Minor allele frequency- A:0.06NS NA 218
    rs178756391,2
    C,F--45827194(-) CCCCCC/TTCTCA 1 -- us2k1 trp35Minor allele frequency- T:0.05NS NA 216
    rs1491438971,2
    --45827218(+) AGTACA/CGTATA 1 -- us2k10--------
    rs1845718531,2
    --45827574(+) AACTGA/GTCTCG 1 -- us2k10--------
    rs178756381,2
    C,F--45827775(-) CCCCCC/AAGAGC 1 -- us2k16Minor allele frequency- A:0.06NS NA CSA 214
    rs72479371,2
    C,F,A,H--45827863(+) gagcaG/Catggg 1 -- us2k114Minor allele frequency- C:0.14NS EA NA WA 1008
    rs1898717721,2
    --45827880(+) GAGAGA/GGTGGG 1 -- us2k10--------
    rs178756371,2
    F--45827926(-) CACCA-/CCATGGGT 1 -- cds12Minor allele frequency- CCA:0.02NS 92
    rs1815116751,2
    --45828057(+) GGTGGA/GTCACT 1 -- us2k10--------
    rs1129260741,2
    C--45828085(+) GACCAC/GCCTGG 1 -- us2k10--------
    rs1132131831,2
    C--45828153(+) CACACG/ACCTGT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs3709345791,2
    ----45821197(+) TCCTCA/GTCACC 2 D syn10--------
    rs725177651,2
    ----45824163(+) ATTAT-/TTATTA
            
    TATTA
    1 -- cds10--------
    rs3712762671,2
    ----45811718(+) CCCCCC/TTTCTC 2 K syn10--------
    rs1465879491,2
    --untested145810137(+) CGATCA/GGCGTT 2 A syn10--------
    rs3702478711,2
    ----45828101(+) ATGGTG/TAAACC 1 -- us2k10--------
    rs3750192321,2
    ----45812355(+) GTGGCA/GGCATC 1 -- int10--------
    rs1383171691,2
    ----45815068(+) GGACAC/TGGGCT 2 M V mis11Minor allele frequency- T:0.00NA 4468
    rs2009405931,2
    ----45813600(+) GTCTCA/GATCTC 1 -- int10--------
    rs5600581,2
    ----45818096(+) tcctgA/Cgtagc 1 -- int10--------
    rs3723791231,2