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CKM Gene(Protein Coding)

Creatine Kinase, M-Type

GCID:
GC19M045306
GIFtS:
67
Genes Participants
UDN Logo

Aliases for CKM Gene

Aliases for CKM Gene

  • Creatine Kinase, M-Type 2 3
  • Creatine Kinase, Muscle 2 3 5
  • Creatine Kinase M Chain 3 4
  • EC 2.7.3.2 4 63
  • CKMM 3 4
  • M-CK 3 4
  • EC 2.7.3 63

External Ids for CKM Gene

Previous HGNC Symbols for CKM Gene

  • CKMM

Previous GeneCards Identifiers for CKM Gene

  • GC19M046454
  • GC19M046200
  • GC19M050485
  • GC19M050501
  • GC19M045809
  • GC19M042241

Summaries for CKM Gene

Entrez Gene Summary for CKM Gene

  • The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKM Gene

CKM (Creatine Kinase, M-Type) is a Protein Coding gene. Diseases associated with CKM include Prostate Rhabdomyosarcoma and Dressler's Syndrome. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Regulation of retinoblastoma protein. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and creatine kinase activity. An important paralog of this gene is CKMT1B.

UniProtKB/Swiss-Prot for CKM Gene

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Gene Wiki entry for CKM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKM Gene

Genomics for CKM Gene

Products:

  1. Regulatory Element

Regulatory Elements for CKM Gene

Enhancers for CKM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CKM on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CKM gene promoter:

Genomic Location for CKM Gene

Chromosome:
19
Start:
45,306,413 bp from pter
End:
45,322,977 bp from pter
Size:
16,565 bases
Orientation:
Minus strand

Genomic View for CKM Gene

Genes around CKM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKM Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CKM Gene

Proteins for CKM Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CKM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06732-KCRM_HUMAN
    Recommended name:
    Creatine kinase M-type
    Protein Accession:
    P06732
    Secondary Accessions:
    • Q96QL9

    Protein attributes for CKM Gene

    Size:
    381 amino acids
    Molecular mass:
    43101 Da
    Quaternary structure:
    • Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

    Three dimensional structures from OCA and Proteopedia for CKM Gene

neXtProt entry for CKM Gene

Proteomics data for CKM Gene at MOPED

Protein Expression for CKM Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CKM Gene

P06732:

Post-translational modifications for CKM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CKM Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CKM Gene

Protein Domains for CKM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CKM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06732

UniProtKB/Swiss-Prot:

KCRM_HUMAN :
  • Contains 1 phosphagen kinase C-terminal domain.
  • Belongs to the ATP:guanido phosphotransferase family.
Domain:
  • Contains 1 phosphagen kinase C-terminal domain.
  • Contains 1 phosphagen kinase N-terminal domain.
Family:
  • Belongs to the ATP:guanido phosphotransferase family.
genes like me logo Genes that share domains with CKM: view

No data available for Gene Families for CKM Gene

Function for CKM Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CKM Gene

GENATLAS Biochemistry:
creatine kinase,muscle
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + creatine = ADP + phosphocreatine.
UniProtKB/Swiss-Prot Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Enzyme Numbers (IUBMB) for CKM Gene

Gene Ontology (GO) - Molecular Function for CKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CKM: view

Phenotypes for CKM Gene

MGI mutant phenotypes for CKM:
inferred from 2 alleles
GenomeRNAi human phenotypes for CKM:
genes like me logo Genes that share phenotypes with CKM: view

Animal Models for CKM Gene

MGI Knock Outs for CKM:

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CKM Gene

Localization for CKM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKM Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKM Gene COMPARTMENTS Subcellular localization image for CKM gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
cytoskeleton 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CKM Gene

Pathways & Interactions for CKM Gene

genes like me logo Genes that share pathways with CKM: view

Gene Ontology (GO) - Biological Process for CKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006595 polyamine metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CKM: view

No data available for SIGNOR curated interactions for CKM Gene

Drugs & Compounds for CKM Gene

Products:

  1. Drug

(15) Drugs for CKM Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Creatine Approved Nutra Target, ligand 110
Adenosine triphosphate Approved Nutra 0
(Diaminomethyl-Methyl-Amino)-Acetic Acid Experimental Pharma Target 0
D-Arginine Experimental Pharma Target 0
Phosphocreatine Pharma 6

(13) Additional Compounds for CKM Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CKM: view

Transcripts for CKM Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CKM Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(987) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CKM Gene

Creatine kinase, muscle:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKM Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1:
SP2: - - - - - - -
SP3: - -
SP4: -

Relevant External Links for CKM Gene

GeneLoc Exon Structure for
CKM
ECgene alternative splicing isoforms for
CKM

Expression for CKM Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CKM Gene

mRNA expression in normal human tissues for CKM Gene
mRNA expression by BioGPS for CKM GenemRNA expression by GTEx for CKM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKM Gene

This gene is overexpressed in Muscle - Skeletal (x41.3) and Heart - Left Ventricle (x6.9).

Protein differential expression in normal tissues from HIPED for CKM Gene

This gene is overexpressed in Tonsil (41.3), Heart (14.2), and Oral epithelium (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CKM Gene



SOURCE GeneReport for Unigene cluster for CKM Gene Hs.334347

genes like me logo Genes that share expression patterns with CKM: view

Protein tissue co-expression partners for CKM Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CKM Gene

Orthologs for CKM Gene

This gene was present in the common ancestor of animals.

Orthologs for CKM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CKM 35
  • 91.95 (n)
  • 96.59 (a)
CKM 36
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CKM 35
  • 91.6 (n)
  • 96.33 (a)
CKM 36
  • 93 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ckm 35
  • 90.29 (n)
  • 96.59 (a)
Ckm 16
Ckm 36
  • 97 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CKM 35
  • 99.39 (n)
  • 100 (a)
CKM 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ckm 35
  • 89.5 (n)
  • 96.06 (a)
oppossum
(Monodelphis domestica)
 Mammalia CKM 36
  • 52 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CKM 36
  • 94 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CKM 35
  • 81.45 (n)
  • 90.29 (a)
lizard
(Anolis carolinensis)
 Reptilia CKM 36
  • 93 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ckm 35
  • 78.92 (n)
  • 87.93 (a)
MGC75682 35
African clawed frog
(Xenopus laevis)
 Amphibia ckm-prov 35
zebrafish
(Danio rerio)
 Actinopterygii ckm 35
ckma 35
  • 80.66 (n)
  • 88.71 (a)
ckma 36
  • 88 (a)
 OneToMany
ckmb 36
  • 85 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Argk 37
  • 39 (a)
CG4546 37
  • 32 (a)
CG5144 37
  • 38 (a)
Argk 36
  • 27 (a)
 ManyToMany
CG30274 36
  • 18 (a)
 ManyToMany
CG4546 36
  • 26 (a)
 ManyToMany
CG5144 36
  • 36 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea F32B5.1 37
  • 38 (a)
F44G3.2 37
  • 37 (a)
W10C8.5 37
  • 38 (a)
ZC434.8 37
  • 39 (a)
F11G11.13 36
  • 32 (a)
 ManyToMany
F32B5.1 36
  • 34 (a)
 ManyToMany
F44G3.2 36
  • 37 (a)
 ManyToMany
F46H5.3 36
  • 37 (a)
 ManyToMany
W10C8.5 36
  • 36 (a)
 ManyToMany
ZC434.8 36
  • 40 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 66 (a)
 ManyToMany
CSA.6164 36
  • 68 (a)
 ManyToMany
Species with no ortholog for CKM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKM Gene

ENSEMBL:
Gene Tree for CKM (if available)
TreeFam:
Gene Tree for CKM (if available)

Paralogs for CKM Gene

Paralogs for CKM Gene

(4) SIMAP similar genes for CKM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CKM: view

Variants for CKM Gene

Sequence variations from dbSNP and Humsavar for CKM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11559024 - 45,317,925(-) CTACG(A/G)AGTTT reference, missense
rs17875653 - 45,315,567(-) ACGTG(C/G/T)TCAGC reference, missense
rs17875625 - 45,308,458(-) GAAGG(C/G)GGGCA reference, missense
rs17357122 - 45,311,905(+) CGCCC(A/G)TCAGG reference, missense
rs7260359 -- 45,311,650(+) AATTA(C/T)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CKM Gene

Variant ID Type Subtype PubMed ID
nsv833844 CNV Loss 17160897
nsv912145 CNV Loss 21882294
nsv912146 CNV Loss 21882294
nsv833845 CNV Loss 17160897
esv2660204 CNV Deletion 23128226
nsv912147 CNV Loss 21882294
dgv3951n71 CNV Loss 21882294
nsv912150 CNV Gain 21882294
nsv912151 CNV Loss 21882294
dgv3952n71 CNV Gain 21882294

Variation tolerance for CKM Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKM Gene

Human Gene Mutation Database (HGMD)
CKM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKM Gene

Disorders for CKM Gene

MalaCards: The human disease database

(12) MalaCards diseases for CKM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate rhabdomyosarcoma
  • rhabdomyosarcoma of the prostate
dressler's syndrome
  • dressler syndrome
borna disease
  • enzootic encephalomyelitis
myotonic dystrophy
  • curschmann-batten-steinert syndrome
hemophilia b
  • congenital factor ix deficiency
- elite association - COSMIC cancer census association via MalaCards
Search CKM in MalaCards View complete list of genes associated with diseases

Relevant External Links for CKM

Genetic Association Database (GAD)
CKM
Human Genome Epidemiology (HuGE) Navigator
CKM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKM
genes like me logo Genes that share disorders with CKM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKM Gene

Publications for CKM Gene

  1. Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme. (PMID: 17000714) Zhou D.Q. … Wen L. (Br J Sports Med 2006) 3 23 25 26
  2. Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-week races? (PMID: 16037885) LucA-a A. … Earnest C.P. (Int J Sports Med 2005) 3 23 48 67
  3. The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase. (PMID: 17303563) Zhao T.J. … Zhou H.M. (J. Biol. Chem. 2007) 3 23
  4. Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. (PMID: 17389266) Zeng L. … Zhang J. (Circulation 2007) 25 26
  5. Capture of monomeric refolding intermediate of human muscle creatine kinase. (PMID: 16373479) Li S. … Zhou H.M. (Protein Sci. 2006) 3 23

Products for CKM Gene

  • Addgene plasmids for CKM

Sources for CKM Gene

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