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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKM Gene

protein-coding   GIFtS: 68
GCID: GC19M045809

creatine kinase, muscle


(Previous symbol: CKMM)
 Explore 39 diseases affiliated with
CKM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CKM    

Aliases
for CKM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Creatine Kinase, Muscle1 2     EC 2.7.3.23 8
CKMM1 2 3 5     Creatine Kinase M-Type2
Creatine Kinase M Chain2 3     EC 2.7.38
M-CK2 3     

External Ids:    HGNC: 19941   Entrez Gene: 11582   Ensembl: ENSG000001048797   OMIM: 1233105   UniProtKB: P067323   

Export aliases for CKM gene to outside databases

Previous GC identifers: GC19M046454 GC19M046200 GC19M050485 GC19M050501 GC19M042241


Summaries
for CKM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CKM:
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum
marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and
various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues,
and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido
phosphotransferase protein family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).
Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy
demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKM


Genomic Views
for CKM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKM gene promoter:
         USF1   USF-1   MyoD   Pax-4a   Arnt   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKM promoter sequence
   Search SABiosciences Chromatin IP Primers for CKM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

CKM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKM gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M045809:  view genomic region     (about GC identifiers)

Start:
 45,809,671 bp from pter      End:
 45,826,235 bp from pter
Size:
 16,565 bases      Orientation:
 minus strand

Proteins
for CKM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732 (See protein sequence)
Recommended Name: Creatine kinase M-type  
Size: 381 amino acids; 43101 Da
Subunit: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB
existing in myocardium, and BB existing in many tissues, especially brain
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for CKM:
1I0E (3D)    
Secondary accessions: Q96QL9

Explore the universe of human proteins at neXtProt for CKM: NX_P06732

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P06732

    • 4/26 DME Specific Peptides for CKM (P06732) (see all 26)
     CPSNLGT  NEEDHLR  GGDDLDP  AGDEESY 

    CKM Protein expression data from MOPED and PaxDb:    About this image 
    CKM Protein Expression
    REFSEQ proteins: NP_001815.2  
    ENSEMBL proteins: 
     ENSP00000221476  
    Reactome Protein details: P06732
    Human Recombinant Protein Products for CKM: 
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    OriGene Custom Protein Services for CKM 
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    Novus Biologicals CKM Proteins
    Novus Biologicals CKM Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CKM
    Uscn Proteins for CKM

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--

    CKM for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CKM

    Protein Domains /
    Families
    for CKM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CKM for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000749 ATP-guanido_PTrfase
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P06732

    ProtoNet protein and cluster: P06732

    1 Blocks protein family: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    Function
    for CKM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRM_HUMAN, P06732
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).
    Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy
    demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Genatlas biochemistry entry for CKM:
    creatine kinase,muscle

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    CKM for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CKM:
     Increased viability after born 

         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ckm):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  muscle 

    CKM for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for CKM: Ckmtm1Bew Ckmtm2Bew
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CKM 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CKM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKM
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CKM:
    hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
    SwitchGear 3'UTR luciferase reporter plasmid: CKM 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKM (see all 7)
    OriGene shRNA RFP: CKM
    OriGene siRNA: CKM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKM
    Sirion Biotech Custom design and validation of potent shRNA sequences against CKM 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CKM
    Sirion Biotech Customized adenovirus for overexpression of CKM 
    Sirion Biotech Customized adenovirus for potent knockdown of CKM

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKM (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKM (see all 2)
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    GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM


    Pathways & Interactions
    for CKM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2Arginine and proline metabolism
    		Arginine and proline metabolism1.00
    		Urea cycle and metabolism of amino groups0.36
    3creatine-phosphate biosynthesis
    		creatine-phosphate biosynthesis1.00
    		Creatine metabolism0.38
    4Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    5AMPK Enzyme Complex Pathway
    		AMPK Enzyme Complex Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CKM
        AMPK Enzyme Complex Pathway

    3 BioSystems Pathways for CKM 
        creatine-phosphate biosynthesis
    Regulation of retinoblastoma protein
    Urea cycle and metabolism of amino groups

    3        Reactome Pathways for CKM
        Creatine metabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for CKM):
        Arginine and proline metabolism
    Metabolic pathways


    CKM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CKM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for CKM (P067323 ENSP000002214764) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q13, ENSP000003633904I2D: score=2 STRING: ENSP00000363390
    CKBP122773, ENSP000002991984I2D: score=1 STRING: ENSP00000299198
    TRIM54Q9BYV23, ENSP000002960984I2D: score=1 STRING: ENSP00000296098
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MYOM2P542963, ENSP000002621134I2D: score=1 STRING: ENSP00000262113
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046314phosphocreatine biosynthetic process IEA--

    CKM for ontologies           About GeneDecksing



    Drugs & Compounds
    for CKM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CKM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKM

    4 HMDB Compounds for CKM    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    PhosphocreatineCreatine phosphate (see all 15)67-07-2--

    4 DrugBank Compounds for CKM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (Diaminomethyl-Methyl-Amino)-Acetic Acid-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Creatine(alpha-Methylguanido)acetic acid (see all 6)57-00-1targetligand17000714 1731757 17389266
    D-Arginine-- 157-06-2target--17139284 17016423 10592235

    10/23 Novoseek chemical compound relationships for CKM gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 84.5 273 19327508 (5), 9808283 (5), 1690725 (3), 9756613 (3) (see all 99)
    phosphocreatine 39.7 2 18979206 (1)
    glycogen 18.9 5 18560415 (2), 15922959 (1)
    percoll 14.9 1 8833742 (1)
    atp 12 4 9516180 (1), 1950416 (1), 18979206 (1)
    pyruvate 9.82 1 9740064 (1)
    chloramphenicol 5.5 1 1690725 (1)
    calcium 3.94 1 15389566 (1)
    oxygen 0 1 11708401 (1)
    nitric oxide 0 1 8617220 (1)

    Search CenterWatch for drugs/clinical trials and news about CKM / KCRM 

    Transcripts
    for CKM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CKM gene: 
    NM_001824.4  

    Unigene Cluster for CKM:

    Creatine kinase, muscle
    Hs.334347  [show with all ESTs]
    Unigene Representative Sequence: NM_001824
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000221476(uc002pbd.3)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CKM:
    hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
    SwitchGear 3'UTR luciferase reporter plasmid: CKM 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKM (see all 7)
    OriGene shRNA RFP: CKM
    OriGene siRNA: CKM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKM
    Sirion Biotech Custom design and validation of potent shRNA sequences against CKM 
    Clone
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    GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
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    Primer
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    Additional cDNA sequence: 

    AK129878.1 AK300730.1 AK313281.1 BC007462.1 BT006793.1 M14780.1 M16440.1 

    16 DOTS entries:

    DT.86999432  DT.91755914  DT.100820874  DT.121502341  DT.102828559  DT.100820873  DT.121502345  DT.100820875 
    DT.121502338  DT.91755923  DT.100820876  DT.100820872  DT.100820877  DT.87000155  DT.95369564  DT.100031850 

    987 AceView cDNA sequences (see top 24):

    F29227 F29176 CD612932 BM874705 F31964 NM_001824 F28206 F30006 
    F22796 F33674 F29199 F15639 F24524 F21295 AJ573003 F36280 
    AA346181 F35273 AL598094 C05040 F30805 F30046 F30182 F18252 
    F36319 F29239 AJ572902 AJ572912 F28465 C04711 F15920 F31033 
    F22753 F18094 F34400 CF552199 F27276 F27175 AJ573041 F30227 
    F15513 F26050 F30037 F29802 F30035 F28905 F26757 AL599011 
    F25434 F26899 F31055 F22533 F25856 F16746 F33305 CA398120 
    F18258 F24170 F25797 CR601202 F28111 F27215 C04321 F29753 
    F20544 F31933 F31475 F31171 F29854 F16665 BQ941643 F27971 
    C05600 F20737 AL599004 F36374 F30865 F20289 AL601227 CA398119 
    F31444 F15631 BP334221 F18053 F26890 F24125 F31990 F22067 
    F15736 F19300 F29376 F30387 F20425 AA295833 F15831 BX280458 
    M16440 CF551995 F27388 BF126218 F18082 F28753 F25691 BX379289 
    F33840 AA112038 F16193 F31572 F27670 C05416 F30436 F28149 
    F32150 F18265 F35023 BV205119 BF672090 AL695050 F33593 F24467 
    F24463 F27086 AJ572058 AJ707932 AJ572979 F34673 F25236 F19406 
    BF671612 CF552732 F33360 F27791 BM450483 BF574429 CF552465 F22727 
    BF672809 CD612921 F28964 F26826 F28574 BF791290 AA179247 F28142 
    F17733 AA112793 BC007462 F19299 F32241 AA192843 BF828738 F24227 
    BI838060 F25730 C04845 F33026 BF574616 F21815 C05434 F30658 
    C03055 AA176743 BQ960378 F32337 F19383 F26514 AJ573063 F15987 
    F19287 AJ572985 F33340 F36196 F34090 F24341 AJ708459 CD612934 
    BF672275 F24644 F18997 CD612922 F15739 F32160 F27427 F33708 
    F21711 BF790990 F32000 F35270 F20261 BF576269 C05347 F29060 
    F25792 BE968679 F32990 F33846 F28383 F28499 F28835 F29217 
    BU631311 F33702 F34146 CD612920 AJ573040 BF670376 F27588 F33696 
    F24957 F36095 AA112949 AA128476 CD612897 F26979 F19355 BT006793 
    F35507 AL694109 BF837993 BF790859 F27037 AA111993 F37505 F28607 
    AJ572975 AA778263 F35445 AA346226 AJ572965 F27061 F29061 F00064 
    T66895 F26649 AJ573978 F24321 N80871 AL597795 F32459 CD612926 
    F33013 F29244 CF552868 F31810 F26858 AJ572936 F36269 F19352 
    F28063 F33855 F15619 BX499963 F36323 BF790610 AA317642 AA346292 
    BF576743 AL598846 C05161 AA196364 F17745 BQ327364 F27126 F19361 
    F33233 F34381 AA192277 F24208 F24047 CD612930 AA346248 F28091 
    BF694839 F27111 CD612900 F27703 BI835773 AJ572380 BF576277 F24251 
    F28912 F35840 AA176850 F35094 F28830 F21329 AJ710991 CF552932 
    BI827111 F22427 F25327 F33858 AA321919 R57150 BF126099 F31631 
    BP335010 F33125 AA196019 F28118 F33361 F32942 F26347 AL598560 
    BX502560 BX503012 F27460 F21300 C04020 F31256 CD612903 AL695520 
    F33349 F24122 F26019 F34391 F28848 F19631 F34745 AI090503 
    F22716 F22790 F26760 F27868 CD612927 CF551853 F26991 BF673021 
    AA478924 F30000 C05531 AA346038 F30550 AA197239 F25957 C04866 
    F37114 F21850 AA345796 F29654 F22717 F27761 F25068 C04070 
    F28584 F20700 AA196120 F36202 F37377 AA180017 F22749 F27582 
    F26476 T28699 F19526 F34175 F19244 F30451 AJ572995 F24798 
    F25995 F19185 CD612906 F19272 C05415 F34291 AJ572867 F32739 
    AA176402 F33403 F24123 BF790462 F26663 AJ573086 AK129878 F19627 
    F17683 F28211 F33640 AJ572230 F25879 F34854 F37367 F21987 
    AJ573013 F33012 F24621 AA722990 F19658 F28462 F35856 F18821 
    AL601405 AL598744 F32609 F35917 F25643 F22008 BQ922516 BX507442 
    F36585 AJ572992 BF790538 F26753 F25429 F31252 AA295080 F20200 
    F26546 AJ573012 BM673090 CD612899 F25791 F31145 F28722 F33839 
    F26764 F24743 C05385 F30328 F33083 F32111 F28196 CD612893 
    CD612925 F23345 F26987 F34916 AA086448 AA214139 BF574963 F01338 
    BF575533 F01097 F19613 F30970 BF670716 F20382 F29600 F25961 
    AA086426 F21198 F35849 F25577 F34187 BQ327362 AA196642 F33162 
    AA478804 F32376 F24075 F17153 CD612931 F29255 AJ708058 AA197163 
    AW984091 BF576327 BX500039 BF126251 CD612911 BF576902 AJ710543 F28083 
    AA195969 F33356 F35424 AA196571 F32660 BX502020 AI370852 F16122 
    F20698 R57855 CD612912 AJ573028 BF790602 CD612929 BF671505 F34891 
    F27819 F26495 F33565 F36144 AA112836 F28785 M14780 AL601414 
    F32858 F19559 F33673 AA176412 F27642 CD612904 F23359 C04088 
    F26303 AA196653 AA193208 F24082 BF840531 CD612916 T11926 F16147 
    F31979 AJ573231 AA025714 F19358 F33662 F19016 F32596 C05325 
    F27097 F33879 F00544 F26020 F16297 F25362 F34199 F25258 
    F16109 F35879 BF692925 F37576 F26920 AA192228 BF574667 AA100433 
    T66871 AL695151 F22440 AA086421 F35255 AA192899 F24384 AA346224 
    F17908 CD612915 R57936 BF673038 CA390685 AA086327 F25975 F26278 
    AA197130 BF840529 F36022 F26674 C05320 AA111913 F24568 F28213 
    F33374 BF670657 BF576701 BF825640 CD612914 F19618 AA086313 F32590 
    C04158 F00509 BF789876 AA085819 F34281 F01081 F22108 F21572 
    C04977 F33008 BF672956 F28069 BF673124 F33010 F35847 AJ708728 
    F27604 F34081 C04226 BF574808 AI246425 F19230 F32824 BF575414 
    F34192 F35116 F37207 F29510 AA112826 CD612923 F26997 F28280 
    BF574783 F34774 CD612898 F31734 AA192226 F22326 F17888 F35929 
    F32924 CD612894 AJ571825 F37031 F32769 AA176521 AA179112 AJ709315 
    F32714 F28100 CD612913 F24146 F33082 F00890 F17689 F29956 
    AA085649 AA085825 F21460 F33587 F21232 F25705 F35220 AA482944 
    BF671480 F19741 F33625 CD612905 F26747 F00063 AA196032 AA086278 
    F33529 AL598215 F26783 AA346049 AA195940 F01084 F32948 F36099 
    F30943 F35593 F22403 C05338 F26585 AA179027 BF671988 F28657 
    F36603 CF551898 BF671277 F34879 F33294 BX379288 F32659 AA977460 
    BF825628 AW449250 F27464 BF770927 AJ346330 AA192328 AA011006 AA197158 
    AA346060 F33352 F32961 AA243705 BF825637 F35397 F25343 F25888 
    C03963 BF575857 BF670665 F33583 F22230 AA196846 AJ573886 F00667 
    F19677 F32085 F35281 F25074 AA176789 F24440 C04654 BQ327365 
    BF789870 AI192691 F33072 AA194342 AA086420 C03023 AA192310 F37660 
    F20236 F22155 BF770930 BF574218 F28553 F29596 F37467 F25452 
    AA346031 AJ572490 F32422 F27493 F20497 CD612928 F22452 F31740 
    F27914 F01269 AJ710542 AA178866 CD612918 AA179111 F16171 AA192575 
    F33092 AA178904 F29388 AA192710 F33847 AA197131 F37893 AA196037 
    AA178935 F18872 AA176488 AA195962 F17120 AA346252 AA314046 AA701473 
    F33390 BF576576 AJ709811 AJ572983 F24061 F35316 F01275 F34847 
    CD612902 F00898 F21657 BF790232 F28278 AA112832 F21325 AA196547 
    AA086442 AA192688 AA975727 F36584 F24058 F37499 F28962 AI193581 
    F33444 F25398 AA192648 BF693033 C04155 F30180 F32304 C02813 
    AA010901 F32773 CD612919 BF790451 AA197250 F19047 F17916 F27865 
    W04731 F20284 F30749 AJ710554 AA197164 C05559 AA193195 F29785 
    F19449 AA214010 AA193547 CD612907 CD612933 AA193246 C03543 F26914 
    AA179122 AA178921 AA216193 AA442525 AA112731 F22755 AA086352 AA086376 
    F33180 AA099639 F22126 AJ574115 F27918 F32417 F24456 T11640 
    AA196021 F29284 F00616 CD612901 F27253 BF827950 C02780 F33129 
    F32931 AW950722 BF790314 F36209 BF825636 AA194460 C02700 AA176673 
    T19650 AA176838 AA194449 AA196366 AJ572997 AJ572837 BF825612 F35087 
    AA112790 AA176949 F37926 BF670793 AA093112 F29494 AI264868 C03406 
    AA196113 BF575942 F28984 AA086249 F33922 F28037 F18848 AA112721 
    AA182851 AA093767 F35091 F19629 F29080 F30905 BF825330 AA196065 
    C03389 BF672738 AA112810 BF574917 F00563 AJ572688 F26329 AA100320 
    BF827504 F24017 C03079 C02718 F25062 AI183675 AA086453 BF825644 
    F36425 F29276 AA194375 CD612908 AA180980 R57025 AA086244 AA197207 
    BF693206 F34055 F01305 C04266 F22784 BF575922 AI292300 AA179819 
    BF789878 F25480 AA193010 AA178919 AA192264 AA099769 F24018 BF770915 
    F28603 F32812 F35144 AA176427 F24178 AI016302 AA192812 C03536 
    F34852 AA448333 BF836257 W07604 AA197249 AA180803 BF825639 AA196681 
    BF670751 AA181375 AA192615 BE968852 BF575016 AA211749 F27479 C03730 
    F25122 AA180464 AA196097 CD612909 BF769618 AA192585 BF825627 C02640 
    F01290 AA179972 AI278015 AA197077 F32454 AA192845 AA181469 AA113000 
    AU099591 AA213955 F32015 F30736 AA176349 BF843371 AA179894 N86694 
    BG990872 BQ327369 AJ572968 AA196847 CD612924 AA196534 AA178978 AA193009 
    C05317 AA179056 F17203 AA112732 AA192922 BF694409 AA086303 BF825633 
    AA182902 T66896 BG991741 BQ327702 AA193072 AA192319 C03123 AA194783 
    CD612917 CD612896 BF695155 BF838919 AA214018 BF791044 AI193243 AA112948 
    AA085814 AA196581 AA196868 BM706602 AA102243 BF671253 AA196089 CD612895 
    CD612910 AA100565 F36308 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CKM    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                                                                          
    SP2:                          -     -     -     -     -     -     -                           
    SP3:                                -     -                                                   
    SP4:              -                                                                           


    ECgene alternative splicing isoforms for CKM

    Expression
    for CKM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCCCGCCC
    CKM Expression
    About this image

    CKM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CKM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKM

    SOURCE GeneReport for Unigene cluster: Hs.334347
        SABiosciences Expression via Pathway-Focused PCR Array including CKM: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKM
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKM
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM

    Orthologs
    for CKM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CKM gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CKM1 creatine kinase, muscle 81.45(n)
    90.29(a)    		   396507  NM_205507.1  NP_990838.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CKM6
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL344965.1(1197-12094)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ckm-prov2 creatine kinase, muscle 80.36(n)    BC042249.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ckm2 creatine kinase, muscle 82.81(n)   30095  BC056706.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Argk3 phosphorylation arginine kinase 39(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ZC434.83 arginine kinase 39(a)
    (best of 4)    		   I(10356154-10357374)   --


    ENSEMBL Gene Tree for CKM (if available)
    TreeFam Gene Tree for CKM (if available) 

    Paralogs
    for CKM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CKM gene
    CKB2  CKMT1B2  CKMT22  CKMT1A2  
    4 SIMAP similar genes for CKM using alignment to 1 protein entry:     KCRM_HUMAN:
    CKB    CKMT2    CKMT1B    CKMT1A

    CKM for paralogs           About GeneDecksing



    Genomic Variants
    for CKM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 NCBI SNPs in CKM are shown (see all 389)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs81119891,2
    		C,F,A,H--45809208(+) AGCCAT/CGGCAG 1 -- int129Minor allele frequency- C:0.34NS EA NA WA CSA 3084
    rs178756311,2
    		C--45809265(-) GTCCCG/ATCTGA 1 -- int12Minor allele frequency- A:0.01NS 80
    rs1896109641,2
    		--45809333(+) CTCAAA/CACTGG 1 -- int10--------
    rs178756301,2
    		C,F--45809344(-) CCCAAC/TGGTCT 1 -- int14Minor allele frequency- T:0.07NS WA 200
    rs1816688081,2
    		--45809554(+) AACTTA/TGCCTC 1 -- int10--------
    rs1118437491,2
    		C--45809672(+) AAGCTT/AAGGCC 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs753793651,2
    		--45809685(+) CAATGC/TTTTTA 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1861891121,2
    		--45809697(+) TTATCA/GCTTTG 1 -- ut310--------
    rs178756291,2
    		C,F,H--45809750(-) TCTAGT/CTAATG 1 -- ut31 ese314Minor allele frequency- C:0.03NS NA WA 1526
    rs178756281,2
    		C,F--45809886(-) CTCTCT/CCCACC 1 -- ut31 ese34Minor allele frequency- C:0.05NS WA 210

    HapMap Linkage Disequilibrium report for CKM (45809671 - 45826235 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CKM: --
    Human Gene Mutation Database (HGMD): CKM

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKM
    DNA2.0 Custom Variant and Variant Library Synthesis for CKM

    Disorders / Diseases
    for CKM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CKM for disorders           About GeneDecksing

    OMIM gene information: 123310    OMIM disorders: --

    20/39 diseases for CKM (see all 39):    About MalaCards
    myocardial infarction    myoadenylate deaminase deficiency    subvalvular aortic stenosis    retinol binding protein
    creatine phosphokinase    muscular dystrophy    dengue hemorrhagic fever    duchenne muscular dystrophy
    acute myocardial infarction    myotonic dystrophy    glycogen storage disease    hemorrhagic fever
    glucose intolerance    amyotrophic lateral sclerosis    urolithiasis    mcleod syndrome
    heart block    ischemic heart disease    oral squamous cell carcinoma    lateral sclerosis

    2 diseases from the University of Copenhagen DISEASES database for CKM:
    Myocardial infarction     Myopathy

    10/15 Novoseek disease relationships for CKM gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myotonic dystrophy 75.8 19 2016086 (2), 2320244 (1), 1971149 (1), 2300239 (1) (see all 14)
    muscular dystrophies 53.9 2 12609502 (1), 11287429 (1)
    muscular dystrophy duchenne 37 1 9274724 (1)
    rhabdomyolysis 22.1 1 9522498 (1)
    ureteral stone 19.6 2 1921018 (1), 1413305 (1)
    acute myocardial infarction 14.4 1 7656437 (1)
    urolithiasis 14.1 2 1921018 (1), 1413305 (1)
    myositis 9.45 1 1370861 (1)
    renal stone 7.03 2 1921018 (1), 1413305 (1)
    necrosis 3.86 1 8617220 (1)

    Genetic Association Database (GAD): CKM
    Human Genome Epidemiology (HuGE) Navigator: CKM (13 documents)

    Export disorders for CKM gene to outside databases

    Publications
    for CKM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CKM gene, integrated from 9 sources (see all 246):
    (articles sorted by number of sources associating them with CKM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-week races? (PubMed id 16037885)1, 4, 9 Lucia A....Earnest C.P. (2005)
    2. Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme. (PubMed id 17000714)1, 7, 9 Zhou D.Q....Wen L. (2006)
    3. Muscle creatine kinase isoenzyme expression in adult human brain. (PubMed id 1690725)1, 2, 9 Hamburg R.J.... Perryman M.B. (1990)
    4. [An A/G polymorphism in muscle-specific creatine kinase gene in Han population in Northern China] (PubMed id 16120572)1, 4, 9 Zhou D.Q....Gong L. (2005)
    5. The caregene study: muscle-specific creatine kinase gene and aerobic power in coronary artery disease. (PubMed id 16079652)1, 4, 9 Defoor J....Vanhees L. (2005)
    6. Crystallization and preliminary X-ray analysis of human muscle creatine kinase. (PubMed id 10089465)1, 2, 9 Tang L.... Lin Z.J. (1999)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Developmental regulation and tissue-specific expression of the human muscle creatine kinase gene. (PubMed id 2903158)1, 2 Trask R.V.... Billadello J.J. (1988)
    10. cDNA cloning and mapping of the human creatine kinase M gene to 19q13. (PubMed id 3031982)1, 2 Nigro J.M....Martin-Deleon P. (1987)

    External Searches for CKM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CKM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1158 HGNC: 1994 AceView: CKM Ensembl:ENSG00000104879 euGenes: HUgn1158
    ECgene: CKM Kegg: 1158 H-InvDB: CKM

    Other Databases showing CKM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CKM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CKM Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Creatine_kinase
    SeattleSNPshttp://pga.gs.washington.edu/data/ckm/
    Wikipedia http://en.wikipedia.org/wiki/CKM_(gene)

    Intellectual Property
    for CKM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CKM gene:
    Search GeneIP for patents involving CKM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CKM gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    von Willebrand factor
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