Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CKM Gene

protein-coding   GIFtS: 68
GCID: GC19M045809

Creatine Kinase, Muscle


(Previous symbol: CKMM)
  See CKM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Creatine Kinase, Muscle1 2     EC 2.7.3.23 8
CKMM1 2 3 5     Creatine Kinase M-Type2
Creatine Kinase M Chain2 3     EC 2.7.38
M-CK2 3     

External Ids:    HGNC: 19941   Entrez Gene: 11582   Ensembl: ENSG000001048797   OMIM: 1233105   UniProtKB: P067323   

Export aliases for CKM gene to outside databases

Previous GC identifers: GC19M046454 GC19M046200 GC19M050485 GC19M050501 GC19M042241


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CKM Gene:
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum
marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP
and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other
tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the
ATP:guanido phosphotransferase protein family. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKM Gene:
CKM (creatine kinase, muscle) is a protein-coding gene. Diseases associated with CKM include mcleod syndrome, and neuroacanthocytosis. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKM gene promoter:
         USF1   USF-1   MyoD   Pax-4a   Arnt   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKM promoter sequence
   Search Chromatin IP Primers for CKM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

CKM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKM gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M045809:  view genomic region     (about GC identifiers)

Start:
45,809,671 bp from pter      End:
45,826,235 bp from pter
Size:
16,565 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732 (See protein sequence)
Recommended Name: Creatine kinase M-type  
Size: 381 amino acids; 43101 Da
Subunit: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and
myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain
1 PDB 3D structure from and Proteopedia for CKM:
1I0E (3D)    
Secondary accessions: Q96QL9

Explore the universe of human proteins at neXtProt for CKM: NX_P06732

Explore proteomics data for CKM at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CKM (P06732) (see all 26)
     CPSNLGT  NEEDHLR  GGDDLDP  AGDEESY 


    See CKM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001815.2  
    ENSEMBL proteins: 
     ENSP00000221476  
    Reactome Protein details: P06732

    CKM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CKM
    OriGene Protein Over-expression Lysate for CKM
    OriGene MassSpec for CKM
    OriGene Custom Protein Services for CKM
    GenScript Custom Purified and Recombinant Proteins Services for CKM
    Novus Biologicals CKM Proteins
    Novus Biologicals CKM Lysates
    Sino Biological Recombinant Protein for CKM
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CKM
    Cloud-Clone Corp. Proteins for CKM

     
    Search eBioscience for Proteins for CKM 

    CKM Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CKM (Creatine Kinase, Muscle/CKMM)
    OriGene Antibodies for CKM
    OriGene Custom Antibody Services for CKM
    Novus Biologicals CKM Antibodies
    Abcam antibodies for CKM (P06732, P12277)
    Cloud-Clone Corp. Antibodies for CKM
    ThermoFisher Antibodies for CKM
    LSBio Antibodies in human, mouse, rat for CKM

    CKM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CKM
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CKM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CKM
    Cloud-Clone Corp. CLIAs for CKM
    Search eBioscience for ELISAs for CKM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P06732

    ProtoNet protein and cluster: P06732

    1 Blocks protein domain: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    Find genes that share domains with CKM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRM_HUMAN, P06732
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
    phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
    fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Genatlas biochemistry entry for CKM:
    creatine kinase,muscle

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with CKM           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CKM:
     Increased viability after born 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ckm):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with CKM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CKM: Ckmtm1Bew Ckmtm2Bew

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CKM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKM

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CKM using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CKM:
    hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
    SwitchGear 3'UTR luciferase reporter plasmidCKM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CKM
    Predesigned siRNA for gene silencing in human, mouse, rat CKM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CKM

    Clone
    Products:
         
    OriGene clones in human, mouse for CKM (see all 7)
    OriGene ORF clones in mouse, rat for CKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
    Sino Biological Human cDNA Clone for CKM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM
    Addgene plasmids for CKM 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CKM
    Browse ESI BIO Cell Lines and PureStem Progenitors for CKM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KCRM_HUMAN, P06732: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    mitochondrion2
    nucleus2
    plasma membrane2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CKM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CKM About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Creatine metabolism0.00
    creatine-phosphate biosynthesis0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Arginine and proline metabolism
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups0.00
    4Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway


    Find genes that share SuperPaths with CKM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CKM
        AMPK Enzyme Complex Pathway

    3 BioSystems Pathways for CKM
        creatine-phosphate biosynthesis
    Regulation of retinoblastoma protein
    Urea cycle and metabolism of amino groups


    1 Reactome Pathway for CKM
        Creatine metabolism

    1 PharmGKB Pathway for CKM
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics

    2 Kegg Pathways  (Kegg details for CKM):
        Arginine and proline metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including CKM: 
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CKM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CKM (P067323 ENSP000002214764) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q13, ENSP000003633904I2D: score=2 STRING: ENSP00000363390
    CKBP122773, ENSP000002991984I2D: score=1 STRING: ENSP00000299198
    TRIM54Q9BYV23, ENSP000002960984I2D: score=1 STRING: ENSP00000296098
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MYOM2P542963, ENSP000002621134I2D: score=1 STRING: ENSP00000262113
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046314phosphocreatine biosynthetic process IEA--

    Find genes that share ontologies with CKM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKM (KCRM)

    4 HMDB Compounds for CKM    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    PhosphocreatineCreatine phosphate (see all 15)67-07-2--

    4 DrugBank Compounds for CKM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (Diaminomethyl-Methyl-Amino)-Acetic Acid-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Creatine(alpha-Methylguanido)acetic acid (see all 6)57-00-1targetligand17000714 1731757 17389266
    D-Arginine-- 157-06-2target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for CKM gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 84.5 273 19327508 (5), 9808283 (5), 1690725 (3), 9756613 (3) (see all 99)
    phosphocreatine 39.7 2 18979206 (1)
    glycogen 18.9 5 18560415 (2), 15922959 (1)
    percoll 14.9 1 8833742 (1)
    atp 12 4 9516180 (1), 1950416 (1), 18979206 (1)
    pyruvate 9.82 1 9740064 (1)
    chloramphenicol 5.5 1 1690725 (1)
    calcium 3.94 1 15389566 (1)
    oxygen 0 1 11708401 (1)
    nitric oxide 0 1 8617220 (1)



    Find genes that share compounds with CKM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CKM gene: 
    NM_001824.4  

    Unigene Cluster for CKM:

    Creatine kinase, muscle
    Hs.334347  [show with all ESTs]
    Unigene Representative Sequence: NM_001824
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000221476(uc002pbd.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CKM using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CKM:
    hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
    SwitchGear 3'UTR luciferase reporter plasmidCKM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CKM
    Predesigned siRNA for gene silencing in human, mouse, rat CKM
    Clone
    Products:
         
    OriGene clones in human, mouse for CKM (see all 7)
    OriGene ORF clones in mouse, rat for CKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM
    Addgene plasmids for CKM 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CKM
    OriGene qSTAR qPCR primer pairs in human, mouse for CKM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKM
      QuantiTect SYBR Green Assays in human, mouse, rat CKM
      QuantiFast Probe-based Assays in human, mouse, rat CKM

    Additional mRNA sequence: 

    AK129878.1 AK300730.1 AK313281.1 BC007462.1 BT006793.1 M14780.1 M16440.1 

    16 DOTS entries:

    DT.86999432  DT.91755914  DT.100820874  DT.121502341  DT.102828559  DT.100820873  DT.121502345  DT.100820875 
    DT.121502338  DT.91755923  DT.100820876  DT.100820872  DT.100820877  DT.87000155  DT.95369564  DT.100031850 

    Selected AceView cDNA sequences (see all 987):

    BQ941643 AJ573003 F21295 F24524 F15639 F29199 F33674 F25434 
    AL599011 F26757 F28905 F30035 F29802 F30037 F30227 F26050 
    AJ573041 F15513 F27276 F27175 CF552199 F34400 F18094 F22753 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CKM    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                                                                          
    SP2:                          -     -     -     -     -     -     -                           
    SP3:                                -     -                                                   
    SP4:              -                                                                           


    ECgene alternative splicing isoforms for CKM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CKM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCCCGCCC
    CKM Expression
    About this image


    CKM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    CKM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334347
        Pathway & Disease-focused RT2 Profiler PCR Array including CKM: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CKM
    OriGene qSTAR qPCR primer pairs in human, mouse for CKM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKM
    QuantiTect SYBR Green Assays in human, mouse, rat CKM
    QuantiFast Probe-based Assays in human, mouse, rat CKM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CKM gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckm1 , 5 creatine kinase, muscle1, 5 90.29(n)1
    96.59(a)1
      7 (9.67 cM)5
    127151  NM_007710.21  NP_031736.11 
     194110945 
    chicken
    (Gallus gallus)
    Aves CKM1 creatine kinase, muscle 81.45(n)
    90.29(a)
      396507  NM_205507.1  NP_990838.1 
    lizard
    (Anolis carolinensis)
    Reptilia CKM6
    creatine kinase, muscle
    93(a)
    1 ↔ 1
    GL344965.1(1198-12130)
    African clawed frog
    (Xenopus laevis)
    Amphibia ckm-prov2 creatine kinase, muscle 80.36(n)    BC042249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ckm2 creatine kinase, muscle 82.81(n)   30095  BC056706.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Argk3 phosphorylation arginine kinase 39(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea ZC434.83 arginine kinase 39(a)
    (best of 4)
      I(10356154-10357374)   --


    ENSEMBL Gene Tree for CKM (if available)
    TreeFam Gene Tree for CKM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CKM gene
    CKB2  CKMT1B2  CKMT22  CKMT1A2  
    4 SIMAP similar genes for CKM using alignment to 1 protein entry:     KCRM_HUMAN:
    CKB    CKMT2    CKMT1B    CKMT1A

    Find genes that share paralogs with CKM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CKM (see all 535)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81119891,2
    C,F,A,H--45809208(+) AGCCAT/CGGCAG 1 -- int129Minor allele frequency- C:0.34NS EA NA WA CSA 3084
    rs178756311,2
    C,F--45809265(-) GTCCCG/ATCTGA 1 -- int12Minor allele frequency- A:0.01NS 80
    rs1896109641,2
    --45809333(+) CTCAAA/CACTGG 1 -- int10--------
    rs178756301,2
    C,F--45809344(-) CCCAAC/TGGTCT 1 -- int14Minor allele frequency- T:0.07NS WA 200
    rs1816688081,2
    --45809554(+) AACTTA/TGCCTC 1 -- int10--------
    rs1118437491,2
    C--45809672(+) AAGCTT/AAGGCC 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs753793651,2
    F--45809685(+) CAATGC/TTTTTA 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1861891121,2
    --45809697(+) TTATCA/GCTTTG 1 -- ut310--------
    rs178756291,2
    C,F,H--45809750(-) TCTAGT/CTAATG 1 -- ut31 ese314Minor allele frequency- C:0.03NS NA WA 1526
    rs178756281,2
    C,F--45809886(-) CTCTCT/CCCACC 1 -- ut31 ese34Minor allele frequency- C:0.05NS WA 210

    HapMap Linkage Disequilibrium report for CKM (45809671 - 45826235 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CKM:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660204CNV Deletion23128226
    nsv912147CNV Loss21882294
    nsv833845CNV Loss17160897
    nsv912151CNV Loss21882294
    nsv912145CNV Loss21882294
    nsv833844CNV Loss17160897
    dgv3951n71CNV Loss21882294
    nsv912146CNV Loss21882294
    dgv3952n71CNV Gain21882294
    nsv912150CNV Gain21882294

    Human Gene Mutation Database (HGMD): CKM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CKM
    DNA2.0 Custom Variant and Variant Library Synthesis for CKM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123310    OMIM disorders: --

    4 diseases for CKM:    
    About MalaCards
    mcleod syndrome    neuroacanthocytosis    hemophilia b    myocardial infarction

    2 diseases from the University of Copenhagen DISEASES database for CKM:
    Myocardial infarction     Myopathy

    Find genes that share disorders with CKM           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CKM gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myotonic dystrophy 75.8 19 2016086 (2), 2320244 (1), 1971149 (1), 2300239 (1) (see all 14)
    muscular dystrophies 53.9 2 12609502 (1), 11287429 (1)
    muscular dystrophy duchenne 37 1 9274724 (1)
    rhabdomyolysis 22.1 1 9522498 (1)
    ureteral stone 19.6 2 1921018 (1), 1413305 (1)
    acute myocardial infarction 14.4 1 7656437 (1)
    urolithiasis 14.1 2 1921018 (1), 1413305 (1)
    myositis 9.45 1 1370861 (1)
    renal stone 7.03 2 1921018 (1), 1413305 (1)
    necrosis 3.86 1 8617220 (1)

    Genetic Association Database (GAD): CKM
    Human Genome Epidemiology (HuGE) Navigator: CKM (13 documents)

    Export disorders for CKM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CKM gene, integrated from 10 sources (see all 250) (see top 10):
    (articles sorted by number of sources associating them with CKM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme. (PubMed id 17000714)1, 4, 7, 9 Zhou D.Q....Wen L. (Br J Sports Med 2006)
    2. Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-week races? (PubMed id 16037885)1, 4, 9 LucA-a A....Earnest C.P. (Int J Sports Med 2005)
    3. Muscle creatine kinase isoenzyme expression in adult human brain. (PubMed id 1690725)1, 2, 9 Hamburg R.J.... Perryman M.B. (J. Biol. Chem. 1990)
    4. Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing. (PubMed id 19422651)1, 4, 9 Santiago C....Lucia A. (amp 2010)
    5. [An A/G polymorphism in muscle-specific creatine kinase gene in Han population in Northern China]. (PubMed id 16120572)1, 4, 9 Zhou D.Q....Gong L. (Yi Chuan 2005)
    6. The caregene study: muscle-specific creatine kinase gene and aerobic power in coronary artery disease. (PubMed id 16079652)1, 4, 9 Defoor J....Vanhees L. (amp 2005)
    7. Crystallization and preliminary X-ray analysis of human muscle creatine kinase. (PubMed id 10089465)1, 2, 9 Tang L.... Lin Z.J. (Acta Crystallogr. D 1999)
    8. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. World-class performance in lightweight rowing: is it genetically influenced? A comparison with cyclists, runners and non-athletes. (PubMed id 18801770)1, 4 Muniesa C.A....Lucia A. (Br J Sports Med 2010)
    11. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    12. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    13. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    14. Developmental regulation and tissue-specific expression of the human muscle creatine kinase gene. (PubMed id 2903158)1, 2 Trask R.V.... Billadello J.J. (J. Biol. Chem. 1988)
    15. cDNA cloning and mapping of the human creatine kinase M gene to 19q13. (PubMed id 3031982)1, 2 Nigro J.M....Martin-Deleon P. (Am. J. Hum. Genet. 1987)
    16. Isolation and sequence analysis of a full-length cDNA for human M creatine kinase. (PubMed id 3778496)1, 2 Perryman M.B.... Roberts R. (Biochem. Biophys. Res. Commun. 1986)
    17. A long-range restriction map of the human chromosome 19q13 region: close physical linkage between CKMM and the ERCC1 and ERCC2 genes. (PubMed id 2309701)1, 9 Smeets H....Siciliano M.J. (Am. J. Hum. Genet. 1990)
    18. Spermatogenesis-related change in the synthesis of the creatine kinase B-type and M-type isoforms in human spermatozoa. (PubMed id 2331374)1, 9 Huszar G. and Vigue L. (Mol. Reprod. Dev. 1990)
    19. The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase. (PubMed id 17303563)1, 9 Zhao T.J....Zhou H.M. (J. Biol. Chem. 2007)
    20. Exploring the role of the active site cysteine in human muscle creatine kinase. (PubMed id 16981706)1, 9 Wang P.F....McLeish M.J. (Biochemistry 2006)
    21. Capture of monomeric refolding intermediate of human muscle creatine kinase. (PubMed id 16373479)1, 9 Li S....Zhou H.M. (Protein Sci. 2006)
    22. CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise. (PubMed id 17478608)1, 9 Heled Y....Deuster P.A. (J. Appl. Physiol. 2007)
    23. Isoleucine 69 and valine 325 form a specificity pocket in human muscle creatine kinase. (PubMed id 15504039)1, 9 Novak W.R....Babbitt P.C. (Biochemistry 2004)
    24. The short MCK1350 promoter/enhancer allows for sufficient dystrophin expression in skeletal muscles of mdx mice. (PubMed id 11922612)1, 9 Larochelle N....Lochmuller H. (Biochem. Biophys. Res. Commun. 2002)
    25. Disrupting of E79 and K138 interaction is responsible for human muscle creatine kinase deficiency diseases. (PubMed id 23274523)1 Wu Q.Y....Xu K.L. (Int. J. Biol. Macromol. 2013)
    26. Three-dimensional mapping of the creatine kinase enzyme reaction rate in muscles of the lower leg. (PubMed id 23436474)1 Parasoglou P....Regatte R.R. (NMR Biomed 2013)
    27. Biomarker level improves the diagnosis of embolic source in ischemic stroke of unknown origin. (PubMed id 22592287)1 Santamarina E....Montaner J. (J. Neurol. 2012)
    28. Creatine kinase MM TaqI and methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms influence exercise-induced C-reactive protein levels. (PubMed id 21516340)1 Miranda-Vilela A.L....Klautau-GuimarALes M.d.e. .N. (Eur. J. Appl. Physiol. 2012)
    29. Comparison of the prognosis of spontaneous and percutaneous coronary intervention-related myocardial infarction. (PubMed id 23122801)1 Leonardi S....Mahaffey K.W. (J. Am. Coll. Cardiol. 2012)
    30. Creatine kinase MM TaqI and methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms influence exercise-induced C-reactive protein levels. (PubMed id 21706313)1 Miranda-Vilela A.L....Klautau-GuimarALes M.d.e. .N. (Eur. J. Appl. Physiol. 2012)
    31. Impact of plaque morphology on creatine kinase-MB elevation in patients with elective stent implantation. (PubMed id 20591515)1 Yonetsu T....Isobe M. (Int. J. Cardiol. 2011)
    32. Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes. (PubMed id 21931810)1 Wang Y....Yan Y.B. (PLoS ONE 2011)
    33. Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy. (PubMed id 21768101)1 Diguet N....Mericskay M. (J. Biol. Chem. 2011)
    34. Diagnosis of ischemic heart disease using CK-MB, troponin-I and ischemia modified albumin. (PubMed id 21456469)1 Dawie J....Azazh A. (Ethiop. Med. J. 2011)
    35. Cardiac troponin T and creatine kinase predict mid-term infarct size and left ventricular function after acute myocardial infarction: a cardiac MR study. (PubMed id 21448949)1 Mayr A....Metzler B. (J Magn Reson Imaging 2011)
    36. Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin. (PubMed id 21426302)1 Chen Z....Zhou H.M. (Biochem. J. 2011)
    37. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
    38. Altered serum creatine kinase level and cardiac function in ischemia-reperfusion injury during percutaneous coronary intervention. (PubMed id 21873942)1 Luo Y....Zhou S.F. (Med. Sci. Monit. 2011)
    39. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    40. Single nucleotide polymorphisms in the myostatin (MSTN) and muscle creatine kinase (CKM) genes are not associated with elite endurance performance. (PubMed id 20536908)1 DAPring F....Bouchard C. (amp 2011)
    41. Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention. (PubMed id 20669347)1 Ying S.Q....Wang J.A. (J Zhejiang Univ Sci B 2010)
    42. The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme. (PubMed id 20525694)1 Ryan P.E....Lipkowitz S. (J. Biol. Chem. 2010)
    43. CK-MM gene polymorphism does not influence the blood CK activity levels after exhaustive eccentric exercise. (PubMed id 20157874)1 Yamin C....Duarte J.A. (Int J Sports Med 2010)
    44. Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study. (PubMed id 20952631)1 Sarzynski M.A....Bouchard C. (Circ Cardiovasc Genet 2010)
    45. Dissecting the key residues crucial for the species-specific thermostability of muscle-type creatine kinase. (PubMed id 20558199)1 Gao Y.S....Zhou H.M. (Int. J. Biol. Macromol. 2010)
    46. Elevated CK-MB values after routine angioplasty predicts worse long-term prognosis in low-risk patients. (PubMed id 19670037)1 Vikenes K....Nordrehaug J.E. (Scand. Cardiovasc. J. 2010)
    47. Predictive value of cardiac troponin-I compared to creatine kinase-myocardial band for the assessment of infarct size as measured by cardiac magnetic resonance. (PubMed id 20588136)1 Di Chiara A....Fioretti P.M. (J Cardiovasc Med (Hagerstown) 2010)
    48. Long-term prognostic value of creatine kinase-myocardial band mass after cardiac surgery in low-risk patients with stable angina. (PubMed id 19039220)1 Vikenes K....Nordrehaug J.E. (Cardiology 2009)
    49. Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race. (PubMed id 19125286)1 Kim H.J....Kim C.K. (Eur. J. Appl. Physiol. 2009)
    50. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    51. Cardiovascular disease testing on the Dimension Vista system: biomarkers of acute coronary syndromes. (PubMed id 19523464)1 Kelley W.E....Christenson R.H. (Clin. Biochem. 2009)
    52. The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions. (PubMed id 19337554)1 Gulmez O....Muderrisoglu H. (Vasc Health Risk Manag 2008)
    53. Duchenne muscular dystrophy and idiopathic hyperCKemia in the same family. (PubMed id 18833644)1 Eeg-Olofsson O....Dahl N. (Eur. J. Paediatr. Neurol. 2008)
    54. Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. (PubMed id 18222470)1 Koyama S.... Sorimachi H. (J. Mol. Biol. 2008)
    55. Significance of CK-elevation in noncompaction with regard to cardiac and neuromuscular disease. (PubMed id 18055044)1 Finsterer J....Krugluger W. (Int. J. Cardiol. 2008)
    56. Cardiac involvement of major thalassemia and evaluation of total serum creatine kinase and creatine kinase-mB isoenzyme and cardiac troponinI in these patients. (PubMed id 18810980)1 Sakha K....Rezamand A. (Pak. J. Biol. Sci. 2008)
    57. ACE ID genotype affects blood creatine kinase response to eccentric exercise. (PubMed id 17885020)1 Yamin C....Amir R.E. (J. Appl. Physiol. 2007)
    58. Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. (PubMed id 17389266)7 Zeng L....Zhang J. (Circulation 2007)
    59. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    60. CK-MM autoantibodies: prevalence, immune complexes, and effect on CK clearance. (PubMed id 16810680)1 Warren G.L....Clarkson P.M. (amp 2006)
    61. The identification of myocilin-associated proteins in the human trabecular meshwork. (PubMed id 16289162)1 Fautsch M.P....Johnson D.H. (Exp. Eye Res. 2006)
    62. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    63. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    64. Does creatinine kinase-MB elevation after percutaneous coronary intervention predict outcomes in 2005? Periprocedural cardiac enzyme elevation predicts adverse outcomes. (PubMed id 16087811)1 Bhatt D.L. and Topol E.J. (Circulation 2005)
    65. Does creatinine kinase-MB elevation after percutaneous coronary intervention predict outcomes in 2005? Cardiac enzyme elevation after successful percutaneous coronary intervention is not an independent predictor of adverse outcomes. (PubMed id 16092153)1 Cutlip D.E. and Kuntz R.E. (Circulation 2005)
    66. MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. (PubMed id 15967462)1 Witt S.H.... Labeit S. (J. Mol. Biol. 2005)
    67. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. (PubMed id 15161933)1 Meek S.E....Piwnica-Worms H. (J. Biol. Chem. 2004)
    68. Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. (PubMed id 12972258)1 Hornemann T....Wallimann T. (J. Mol. Biol. 2003)
    69. Hyperubiquitination of proteins in dilated cardiomyopathy. (PubMed id 12601813)1 Weekes J....Dunn M.J. (Proteomics 2003)
    70. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. (PubMed id 12432079)1 Lange S.... Ehler E. (J. Cell Sci. 2002)
    71. Myocardial creatine kinase expression after left ventricular assist device support. (PubMed id 12039490)1 Park S.J....Bache R.J. (J. Am. Coll. Cardiol. 2002)
    72. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    73. Creatine and creatinine metabolism. (PubMed id 10893433)1 Wyss M. and Kaddurah-Daouk R. (Physiol. Rev. 2000)
    74. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    75. Subunit conformation and dynamics in a heterodimeric protein: studies of the hybrid isozyme of creatine kinase. (PubMed id 9748661)1 Grossman S.H. and Sellers D.S. (Biochim. Biophys. Acta 1998)
    76. Sequence verification of human creatine kinase (43 kDa) isozymes by high-resolution tandem mass spectrometry. (PubMed id 8524781)1 Wood T.D....McLafferty F.W. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    77. Creatine kinase in non-muscle tissues and cells. (PubMed id 7808454)1 Wallimann T. and Hemmer W. (Mol. Cell. Biochem. 1994)
    78. Functional aspects of creatine kinase in brain. (PubMed id 7805577)1 Hemmer W. and Wallimann T. (Dev. Neurosci. 1993)
    79. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. (PubMed id 1731757)7 Wallimann T....Eppenberger H.M. (Biochem. J. 1992)
    80. Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. (PubMed id 2914937)1 Haas R.C....Strauss A.W. (J. Biol. Chem. 1989)
    81. Creatine kinase activity in normal and Duchenne muscular dystrophy fibroblasts. (PubMed id 7057800)1 Davis M.H....Gruenstein E. (amp 1982)
    82. Biochemical markers of early and late spermatogenesis: relationship between the lactate dehydrogenase-X and creatine kinase-M isoform concentrations in human spermatozoa. (PubMed id 9052941)9 Lalwani S....Huszar G. (Mol. Reprod. Dev. 1996)
    83. Creatine kinase gene mutation in a patient with muscle creatine kinase deficiency. (PubMed id 11673364)9 Yamamichi H....Koshiba M. (Clin. Chem. 2001)
    84. Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle. (PubMed id 8993831)9 Ferrari S....Cossu G. (amp 1997)
    85. Assessment of a creatine kinase isoform M defect as a cause of myotonic dystrophy and the characterization of two novel CKMM polymorphisms. (PubMed id 2016086)9 Bailly J....Korneluk R.G. (Hum. Genet. 1991)
    86. p53-dependent activation of the mouse MCK gene promoter: identification of a novel p53-responsive sequence and evidence for cooperation between distinct p53 binding sites. (PubMed id 7488858)9 Jackson P....Braithwaite A. (Gene Expr. 1995)
    87. Spatial distribution of &quot;tissue-specific&quot; antigens in the developing human heart and skeletal muscle. I. An immunohistochemical analysis of creatine kinase isoenzyme expression patterns. (PubMed id 2240609)9 Wessels A....Moorman A.F. (Anat. Rec. 1990)
    88. A novel site in the muscle creatine kinase enhancer is required for expression in skeletal but not cardiac muscle. (PubMed id 8617727)9 Fabre-Suver C. and Hauschka S.D. (J. Biol. Chem. 1996)
    89. Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19. (PubMed id 2300239)9 Yamaoka L.H....Mathieu J. (Neurology 1990)
    90. Regulation of muscle creatine kinase by phosphorylation in normal and diabetic hearts. (PubMed id 18979206)9 Lin G....MacLeod K.M. (Cell. Mol. Life Sci. 2009)
    91. Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts. (PubMed id 11861503)9 Sumitani S....Kasayama S. (Endocrinology 2002)
    92. [Human creatine kinase deficiency]. (PubMed id 12166076)9 Yamamichi H. and Ohkawa J. (Rinsho Byori 2002)
    93. Linkage between a muscle-specific CK gene marker and VO2max in the HERITAGE Family Study. (PubMed id 10331890)9 Rivera M.A....Bouchard C. (Med Sci Sports Exerc 1999)
    94. Synergistic transcriptional activation of the MCK promoter by p53: tetramers link separated DNA response elements by DNA looping. (PubMed id 9464547)9 Jackson P....Barrett J. (Oncogene 1998)
    95. Homeodomain protein MHox and MADS protein myocyte enhancer-binding factor-2 converge on a common element in the muscle creatine kinase enhancer. (PubMed id 8206996)9 Cserjesi P....Olson E.N. (J. Biol. Chem. 1994)
    96. Lack of toxicity of alpha-sarcoglycan overexpression supports clinical gene transfer trial in LGMD2D. (PubMed id 18525034)9 Rodino-Klapac L.R....Mendell J.R. (Neurology 2008)
    97. Hybrid retroviral vector with MCK enhancers inserted in LTR for stable and specific expression of human factor IX in skeletal muscle. (PubMed id 15198894)9 Wang J.M....Xue J.L. (Chin. Med. J. 2004)
    98. Analysis of the DNA-binding properties of MyoD, myogenin, and E12 by fluorescence anisotropy. (PubMed id 12196028)9 Maleki S.J....Hurlburt B.K. (Biochemistry 2002)
    99. The isoenzyme-diagnostic regions of muscle-type creatine kinase, the M-260 and M-300 box, are not responsible for its binding to the myofibrillar M-band. (PubMed id 9808283)9 Stolz M....Wallimann T. (Eur. J. Cell Biol. 1998)
    100. p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene. (PubMed id 9690516)9 Tamir Y. and Bengal E. (Oncogene 1998)
    101. Inhibition of myogenesis by multiple cyclin-Cdk complexes. Coordinate regulation of myogenesis and cell cycle activity at the level of E2F. (PubMed id 8995365)9 Guo K. and Walsh K. (J. Biol. Chem. 1997)
    102. Reduction of four-and-a-half LIM-protein 2 expression occurs in human left ventricular failure and leads to altered localization and reduced activity of metabolic enzymes. (PubMed id 19327508)9 Bovill E....Shaw T. (J. Thorac. Cardiovasc. Surg. 2009)
    103. Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes. (PubMed id 18710939)9 Himeda C.L....Hauschka S.D. (Mol. Cell. Biol. 2008)
    104. Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. (PubMed id 10899824)9 Hauser M.A....Chamberlain J.S. (Mol. Ther. 2000)
    105. Cytoplasmic extrusion and the switch from creatine kinase B to M isoform are completed by the commencement of epididymal transport in human and stallion spermatozoa. (PubMed id 9537287)9 Huszar G....Johnson L. (J. Androl. 1998)
    106. E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. (PubMed id 8393137)9 Taylor D.A....Kraus W.E. (Mol. Cell. Biol. 1993)
    107. Rabbit muscle creatine kinase: genomic cloning, sequencing, and analysis of upstream sequences important for expression in myocytes. (PubMed id 2057360)9 Yi T.M....Schimmel P. (Nucleic Acids Res. 1991)
    108. Linkage disequilibrium detected between dystrophia myotonica and APOC2 locus in the Finnish population. (PubMed id 1977684)9 Nokelainen P....Peltonen L. (Hum. Genet. 1990)
    109. Effect of macro-creatine kinase and increased creatine kinase BB on the rapid diagnosis of patients with suspected acute myocardial infarction in the emergency department. (PubMed id 16173202)9 Serdar M.A....Kutluay T. (Mil Med 2005)
    110. An unusually low pK(a) for Cys282 in the active site of human muscle creatine kinase. (PubMed id 11570870)9 Wang P.F....Kenyon G.L. (Biochemistry 2001)
    111. Role of creatine kinase isoenzymes on muscular and cardiorespiratory endurance: genetic and molecular evidence. (PubMed id 11708401)9 Echegaray M. and Rivera M.A. (Sports Med 2001)
    112. Kinetics of slow reversible inhibition of human muscle creatine kinase by planar anions. (PubMed id 9756613)9 Luo W....Zhou H.M. (J. Biochem. 1998)
    113. Myofibrillar interaction of cytosolic creatine kinase (CK) isoenzymes: allocation of N-terminal binding epitope in MM-CK and BB-CK. (PubMed id 9547297)9 Stolz M. and Wallimann T. (J. Cell. Sci. 1998)
    114. Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogenin. (PubMed id 9024793)9 Katagiri T....Suda T. (Exp. Cell Res. 1997)
    115. Muscle-specific creatine kinase gene polymorphism and VO2max in the HERITAGE Family Study. (PubMed id 9346161)9 Rivera M.A....Bouchard C. (Med Sci Sports Exerc 1997)
    116. The prognostic value of serum troponin T in unstable angina. (PubMed id 8793576)9 GAPkhan Cin V....KaptanoA9lu B. (Int. J. Cardiol. 1996)
    117. Use of creatine kinase isoforms for diagnosis of infarct artery patency after thrombolytic therapy with streptokinase. (PubMed id 8269212)9 Norris R.M....White H.D. (Coron. Artery Dis. 1993)
    118. Effect of extracorporeal shockwave lithotripsy for urolithiasis on concentrations of creatine kinase isozymes in patient serum and urine. (PubMed id 1413305)9 Hasegawa S....Miyake K. (Urol. Int. 1992)
    119. [S100a0 protein and creatine kinase isozymes (CK-B &amp; CK-M) in serum and urine might be useful markers for non specific tissue damages by extracorporeal shockwave lithotripsy (ESWL)]. (PubMed id 1921018)9 Hasegawa S....Miyake K. (Nippon Hinyokika Gakkai Zasshi 1991)
    120. Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding. (PubMed id 1847137)9 Chakraborty T....Olson E. (J. Biol. Chem. 1991)
    121. Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. (PubMed id 2163343)9 Brennan T.J. and Olson E.N. (amp 1990)
    122. Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. (PubMed id 18560415)9 Sun B....Koeberl D.D. (Mol. Ther. 2008)
    123. Molecular mechanism of transforming growth factor-beta-mediated inhibition of growth arrest and differentiation in a myoblast cell line. (PubMed id 18211587)9 Murakami M....Nakamura M. (amp 2008)
    124. Muscle creatine kinase/SV40 hybrid promoter for muscle-targeted long-term transgene expression. (PubMed id 17203206)9 Takeshita F....Sasaki S. (Int. J. Mol. Med. 2007)
    125. Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation. (PubMed id 16162663)9 van der Velden J.L....Schols A.M. (Am. J. Physiol., Cell Physiol. 2006)
    126. Sodium barbital is a slow reversible inactivator of rabbit-muscle creatine kinase. (PubMed id 16609694)9 Shi F....Wu P. (Biochem. Cell Biol. 2006)
    127. Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genes. (PubMed id 15908587)9 Yafe A....Fry M. (Nucleic Acids Res. 2005)
    128. Effect of varicocelectomy on sperm creatine kinase, HspA2 chaperone protein (creatine kinase-M type), LDH, LDH-X, and lipid peroxidation product levels in infertile men with varicocele. (PubMed id 16140088)9 YeA9illi C....Mungan A. (Urology 2005)
    129. Effects of oral creatine and resistance training on myogenic regulatory factor expression. (PubMed id 12783039)9 Willoughby D.S. and Rosene J.M. (Med Sci Sports Exerc 2003)
    130. Structure of human muscle creatine kinase. (PubMed id 11517911)9 Shen Y.Q....Lin Z.J. (Acta Crystallogr. D Biol. Crystallogr. 2001)
    131. Differential biological activities of mammalian Id proteins in muscle cells. (PubMed id 10047451)9 Melnikova I.N....Christy B.A. (Exp. Cell Res. 1999)
    132. Morphometric assessment of mature and diminished-maturity human spermatozoa: sperm regions that reflect differences in maturity. (PubMed id 10438418)9 Gergely A....Huszar G. (Hum. Reprod. 1999)
    133. Absence of myofibrillar creatine kinase and diaphragm isometric function during repetitive activation. (PubMed id 9516180)9 LaBella J.J....Watchko J.F. (J. Appl. Physiol. 1998)
    134. Bed rest decreases mechanically induced myofiber wounding and consequent wound-mediated FGF release. (PubMed id 9688737)9 Clarke M.S....Feeback D.L. (J. Appl. Physiol. 1998)
    135. Functional coupling of creatine kinases in muscles: species and tissue specificity. (PubMed id 9746324)9 Ventura-Clapier R....Anflous K. (Mol. Cell. Biochem. 1998)
    136. bFGF induces BCK promoter-driven expression in muscle via increased binding of a nuclear protein. (PubMed id 9252460)9 Kim L....Ritchie M.E. (Am. J. Physiol. 1997)
    137. Muscle-specific creatine kinase gene polymorphisms in elite endurance athletes and sedentary controls. (PubMed id 9372480)9 Rivera M.A....Bouchard C. (Med Sci Sports Exerc 1997)
    138. Inhibition of muscle-specific gene expression by Id3: requirement of the C-terminal region of the protein for stable expression and function. (PubMed id 9016574)9 Chen B....Lim R.W. (Nucleic Acids Res. 1997)
    139. Sperm plasma membrane remodeling during spermiogenetic maturation in men: relationship among plasma membrane beta 1,4-galactosyltransferase, cytoplasmic creatine phosphokinase, and creatine phosphokinase isoform ratios. (PubMed id 9096886)9 Huszar G....Shur B.D. (Biol. Reprod. 1997)
    140. Creatine kinase isoform electrophoresis for the early confirmation of myocardial infarction detected by timed sequential CK slope analysis. (PubMed id 7824414)9 Chattington P....Neithercut W.D. (Postgrad Med J 1994)
    141. Expression of the mitochondrial creatine kinase genes. (PubMed id 7808456)9 Payne R.M. and Strauss A.W. (Mol. Cell. Biochem. 1994)
    142. Activation of muscle-specific transcription by myogenic helix-loop-helix proteins. (PubMed id 1341046)9 Olson E. (Symp. Soc. Exp. Biol. 1992)
    143. Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. (PubMed id 1313772)9 Li L....Olson E.N. (amp 1992)
    144. Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer. (PubMed id 1329039)9 Yutzey K.E. and Konieczny S.F. (Nucleic Acids Res. 1992)
    145. DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. (PubMed id 1314394)9 Johnson J.E....Anderson D.J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    146. Molecular analysis of the myoadenylate deaminase deficiencies. (PubMed id 1370861)9 Sabina R.L.... Holmes E.W. (Neurology 1992)
    147. Prenatal diagnosis of myotonic dystrophy using closely linked flanking markers. (PubMed id 2002492)9 Lavedan C....Junien C. (J. Med. Genet. 1991)
    148. Immunohistochemical study of creatine kinase isozymes in the human upper limb bud. (PubMed id 1950416)9 Shinohara H....Kato K. (Acta Anat (Basel) 1991)
    149. Identification by protein microsequencing of a proteinase-V8-cleavage site in a folding intermediate of chick muscle creatine kinase. (PubMed id 1684894)9 Morris G.E. and Jackson P.J. (Biochem. J. 1991)
    150. A new polymorphic probe which defines the region of chromosome 19 containing the myotonic dystrophy locus. (PubMed id 1971149)9 Johnson K....Rundle S. (Am. J. Hum. Genet. 1990)
    151. Nfix regulates fetal-specific transcription in developing skeletal muscle. (PubMed id 20178747)9 Messina G....Cossu G. (Cell 2010)
    152. Desmin-regulated lentiviral vectors for skeletal muscle gene transfer. (PubMed id 19935780)9 Talbot G.E....Antoniou M.N. (Mol. Ther. 2010)
    153. Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins. (PubMed id 19154341)9 Guillon B....Bouton C. (FEBS J. 2009)
    154. Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. (PubMed id 19598125)9 Bourdelas A....Shi D.L. (Int. J. Dev. Biol. 2009)
    155. Unique among unique. Is it genetically determined? (PubMed id 18662936)9 Gonzalez-Freire M....Lucia A. (Br J Sports Med 2009)
    156. Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. (PubMed id 19357233)9 Trendelenburg A.U....Glass D.J. (Am. J. Physiol., Cell Physiol. 2009)
    157. Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma. (PubMed id 18485002)9 Patra S....Ray M. (FEBS J. 2008)
    158. Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity. (PubMed id 18305954)9 Su Q.S....Zhang H. (Eur. J. Appl. Physiol. 2008)
    159. Progress toward a nonviral gene therapy protocol for the treatment of anemia. (PubMed id 17376007)9 SebestyAcn M.G....Wolff J.A. (Hum. Gene Ther. 2007)
    160. Fertility testing and ICSI sperm selection by hyaluronic acid binding: clinical and genetic aspects. (PubMed id 17509211)9 Huszar G....Ozkavukcu S. (Reprod. Biomed. Online 2007)
    161. Autologous transplantation of muscle precursor cells modified with a lentivirus for muscular dystrophy: human cells and primate models. (PubMed id 17235323)9 Quenneville S.P....Tremblay J.P. (Mol. Ther. 2007)
    162. alpha-tocopherol supplementation reduces the elevated 8-hydroxy-2-deoxyguanosine blood levels induced by training in basketball players. (PubMed id 16879069)9 Tsakiris S....Schulpis K.H. (Clin. Chem. Lab. Med. 2006)
    163. Interfacial behavior of cytoplasmic and mitochondrial creatine kinase oligomeric states. (PubMed id 16283667)9 Vernoux N....Vial C. (Biopolymers 2006)
    164. Glucose tolerance and insulin sensitivity following an one-week volleyball competition. (PubMed id 16970246)9 Kuo M.C....Kuo C.H. (Chin J Physiol 2006)
    165. MicroRNA-1 facilitates skeletal myogenic differentiation without affecting osteoblastic and adipogenic differentiation. (PubMed id 17045567)9 Nakajima N....Oh H. (Biochem. Biophys. Res. Commun. 2006)
    166. Ectopic expression of a polyalanine expansion mutant of poly(A)-binding protein N1 in muscle cells in culture inhibits myogenesis. (PubMed id 16378590)9 Wang Q. and Bag J. (Biochem. Biophys. Res. Commun. 2006)
    167. Identification of differentially expressed, tumor-associated proteins in oral squamous cell carcinoma by proteomic analysis. (PubMed id 16568407)9 Turhani D....Fountoulakis M. (Electrophoresis 2006)
    168. Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level. (PubMed id 16537411)9 Ilany J....Kahn C.R. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    169. Hypertrophy and transcriptional regulation induced in myogenic cell line L6-C5 by an increase of extracellular calcium. (PubMed id 15389566)9 De Arcangelis V....Naro F. (J. Cell. Physiol. 2005)
    170. Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter. (PubMed id 15922959)9 Sun B....Koeberl D.D. (Mol. Ther. 2005)
    171. A differential proteome in tumors suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen. (PubMed id 15717328)9 Huang C.M....Tang D.C. (Proteomics 2005)
    172. The role of extrahepatic retinol binding protein in the mobilization of retinoid stores. (PubMed id 15314099)9 Quadro L....Colantuoni V. (J. Lipid Res. 2004)
    173. Laminin alpha2 deficiency and muscular dystrophy; genotype-phenotype correlation in mutant mice. (PubMed id 12609502)9 Guo L.T....Engvall E. (Neuromuscul. Disord. 2003)
    174. Leukocyte-depleted terminal blood cardioplegia provides superior myocardial protective effects in association with myocardium-derived nitric oxide and peroxynitrite production for patients undergoing prolonged aortic crossclamping for more than 120 minutes. (PubMed id 14688692)9 Hayashi Y....Matsuda H. (J. Thorac. Cardiovasc. Surg. 2003)
    175. Proteolytic susceptibility of creatine kinase isozymes and arginine kinase. (PubMed id 12821144)9 Ercan A. and Grossman S.H. (Biochem. Biophys. Res. Commun. 2003)
    176. Increased creatine kinase and spontaneous activity on electromyography, in amyotrophic lateral sclerosis. (PubMed id 12712806)9 Lima A.F....de Carvalho M. (Electromyogr Clin Neurophysiol 2003)
    177. ADAM 12 protease induces adipogenesis in transgenic mice. (PubMed id 12000741)9 Kawaguchi N....Wewer U.M. (Am. J. Pathol. 2002)
    178. The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. (PubMed id 11713257)9 Chen S.L....Muscat G.E. (J. Biol. Chem. 2002)
    179. Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice. (PubMed id 12048218)9 Quadro L....Gottesman M.E. (J. Biol. Chem. 2002)
    180. [Establishment of a hemophilia B transgenic mouse model on the basis of coagulation factor IX gene knock-out mouse]. (PubMed id 12143307)9 Che W.L....Fu J.L. (Yi Chuan Xue Bao 2002)
    181. Multiple isoforms and an unusual cathodic isoform of creatine kinase from channel catfish (Ictalurus punctatus). (PubMed id 11587847)9 Liu Z....Karsi A. (Gene 2001)
    182. Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies. (PubMed id 11177557)9 Cordier L....Sweeney H.L. (Hum. Gene Ther. 2001)
    183. Overexpression of gamma-sarcoglycan induces severe muscular dystrophy. Implications for the regulation of Sarcoglycan assembly. (PubMed id 11287429)9 Zhu X....McNally E.M. (J. Biol. Chem. 2001)
    184. Mutagenesis of two acidic active site residues in human muscle creatine kinase: implications for the catalytic mechanism. (PubMed id 11258919)9 Cantwell J.S....Babbitt P.C. (Biochemistry 2001)
    185. Designing gene therapy vectors: avoiding immune responses by using tissue-specific promoters. (PubMed id 11821941)9 Weeratna R.D....Davis H.L. (Gene Ther. 2001)
    186. Creatine kinase in human retinal pigment epithelium. (PubMed id 10655143)9 Kennedy B.G....Mangini N.J. (Exp. Eye Res. 2000)
    187. Interactions between beta-enolase and creatine kinase in the cytosol of skeletal muscle cells. (PubMed id 10657248)9 Foucault G....Arrio-Dupont M. (Biochem. J. 2000)
    188. Rescue of skeletal muscles of gamma-sarcoglycan-deficient mice with adeno-associated virus-mediated gene transfer. (PubMed id 10933922)9 Cordier L....Sweeney H.L. (Mol. Ther. 2000)
    189. Cardiac fatigue following prolonged endurance exercise of differing distances. (PubMed id 10862531)9 Whyte G.P....McKenna W.J. (Med Sci Sports Exerc 2000)
    190. Isoenzyme-specific interaction of muscle-type creatine kinase with the sarcomeric M-line is mediated by NH(2)-terminal lysine charge-clamps. (PubMed id 10851020)9 Hornemann T....Wallimann T. (J. Cell Biol. 2000)
    191. Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is independent of scavenger receptor class B type 1. (PubMed id 10896681)9 Seo T....Deckelbaum R.J. (J. Biol. Chem. 2000)
    192. Presence of enolase in the M-band of skeletal muscle and possible indirect interaction with the cytosolic muscle isoform of creatine kinase. (PubMed id 9931306)9 Foucault G....Arrio-Dupont M. (Biochem. J. 1999)
    193. [Brain isoforms of creatine kinase in health and mental diseases: Alzheimer's disease and schizophrenia]. (PubMed id 10078058)9 Burbaeva G.S.h....Dmitriev A.D. (Vestn. Akad. Med. Nauk SSSR 1999)
    194. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor. (PubMed id 9988769)9 Zetser A....Bengal E. (J. Biol. Chem. 1999)
    195. Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast. (PubMed id 10455404)9 Bou-Gharios G....Partridge T. (Gene Ther. 1999)
    196. Lack of requirement for presenilin1 in Notch1 signaling. (PubMed id 10607593)9 Berechid B.E....Nye J.S. (Curr. Biol. 1999)
    197. [Serum creatine kinase MM isoforms and lactate dehydrogenase isoenzymes in patients with non-traumatic acute rhabdomyolysis]. (PubMed id 9522498)9 Sanchez Navarro M.R....Oliver Almendros C. (An Med Interna 1998)
    198. Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. (PubMed id 9546431)9 Comer K.A....Kumar C.C. (Oncogene 1998)
    199. Protein changes observed in pacing-induced heart failure using two-dimensional electrophoresis. (PubMed id 9740064)9 Heinke M.Y....dos Remedios C.G. (Electrophoresis 1998)
    200. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. (PubMed id 9811888)9 Merkel M....Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    201. Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts. (PubMed id 9299160)9 Akiyama S....Suda T. (Exp. Cell Res. 1997)
    202. Lipoprotein lipase regulates Fc receptor-mediated phagocytosis by macrophages maintained in glucose-deficient medium. (PubMed id 9239412)9 Yin B....Goldberg I.J. (J. Clin. Invest. 1997)
    203. Modulation of the specificity and activity of a cellular promoter in an adenoviral vector. (PubMed id 9054515)9 Shi Q....Worton R. (Hum. Gene Ther. 1997)
    204. Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase. (PubMed id 9277555)9 Jensen D.R....Eckel R.H. (Am. J. Physiol. 1997)
    205. Efficient muscle-specific transgene expression after adenovirus-mediated gene transfer in mice using a 1.35 kb muscle creatine kinase promoter/enhancer. (PubMed id 9274724)9 Larochelle N....Nalbantoglu J. (Gene Ther. 1997)
    206. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts. (PubMed id 9268344)9 Namiki M....Suda T. (J. Biol. Chem. 1997)
    207. High expression of human clotting factor IX cDNA in myoblasts C2C12 cells and C3H mice. (PubMed id 18762876)9 Wang H....Xue J. (Sci. China, C, Life Sci. 1997)
    208. Sperm function and choice of preparation media: comparison of Percoll and Accudenz discontinuous density gradients. (PubMed id 8833742)9 Sbracia M....Huszar G. (J. Androl. 1996)
    209. Overexpression of myotonic dystrophy kinase in BC3H1 cells induces the skeletal muscle phenotype. (PubMed id 8550617)9 Bush E.W....Perryman M.B. (J. Biol. Chem. 1996)
    210. Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. (PubMed id 9118584)9 Desager J.P. and Horsmans Y. (Clin Pharmacokinet 1996)
    211. Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action. (PubMed id 8941652)9 Thompson D.B....Ossowski V. (J. Clin. Invest. 1996)
    212. Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms. (PubMed id 8816442)9 Tiainen M....Crescenzi M. (Mol. Cell. Biol. 1996)
    213. Construction of human factor IX expression vectors in retroviral vector frames optimized for muscle cells. (PubMed id 8886845)9 Wang J.M....Kurachi K. (Hum. Gene Ther. 1996)
    214. The effect of eccentric exercise on serum creatine kinase activity in different ethnic groups. (PubMed id 8836390)9 Sherwood R.A....Peters T.J. (Ann. Clin. Biochem. 1996)
    215. MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells. (PubMed id 8798771)9 Ornatsky O.I. and McDermott J.C. (J. Biol. Chem. 1996)
    216. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. (PubMed id 8617220)9 Buck M. and Chojkier M. (EMBO J. 1996)
    217. A continuous high-resolution physical map spanning 17 megabases of the q12, q13.1, and q13.2 cytogenetic bands of human chromosome 19. (PubMed id 7665184)9 Garcia E....Lamerdin J. (Genomics 1995)
    218. Gene for progressive familial heart block type I maps to chromosome 19q13. (PubMed id 7882468)9 Brink P.A....Corfield V.A. (Circulation 1995)
    219. Equivalent early sensitivities of myoglobin, creatine kinase MB mass, creatine kinase isoform ratios, and cardiac troponins I and T for acute myocardial infarction. (PubMed id 7656437)9 Mair J....Puschendorf B. (Clin. Chem. 1995)
    220. A retroviral vector containing a muscle-specific enhancer drives gene expression only in differentiated muscle fibers. (PubMed id 7548273)9 Ferrari G....Mavilio F. (Hum. Gene Ther. 1995)
    221. Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. (PubMed id 7605578)9 Ghebranious N....Sell S. (Mol. Carcinog. 1995)
    222. Myotonic dystrophy: molecular analysis of Israeli patients. (PubMed id 7858174)9 Abeliovich D....Cohen T. (amp 1994)
    223. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. (PubMed id 7798324)9 Katagiri T....Suda T. (J. Cell Biol. 1994)
    224. Improved quantification with validation of multiple mRNA species by polymerase chain reaction: application to human myocardial creatine kinase M and B. (PubMed id 8181032)9 Ma T.S....Roberts R. (Cardiovasc. Res. 1994)
    225. Primary myoblast-mediated gene transfer: persistent expression of human factor IX in mice. (PubMed id 7584074)9 Yao S.N....Kurachi K. (Gene Ther. 1994)
    226. Physical and functional interaction between WT1 and p53 proteins. (PubMed id 8389468)9 Maheswaran S....Haber D.A. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    227. Identification of DNA-binding protein(s) in the developing heart. (PubMed id 8462740)9 Litvin J....Bader D.M. (Dev. Biol. 1993)
    228. Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain. (PubMed id 8413199)9 Hardy S....Konieczny S.F. (Mol. Cell. Biol. 1993)
    229. Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. (PubMed id 1644289)9 Jen Y....Benezra R. (amp 1992)
    230. Functional antagonism between c-Jun and MyoD proteins: a direct physical association. (PubMed id 1310896)9 Bengal E....Verma I.M. (Cell 1992)
    231. Identification of MRF4, myogenin, and E12 oligomer complexes by chemical cross-linking and two-dimensional gel electrophoresis. (PubMed id 1311321)9 Lin H. and Konieczny S.F. (J. Biol. Chem. 1992)
    232. The human skeletal alpha-actin gene is regulated by a muscle-specific enhancer that binds three nuclear factors. (PubMed id 1633435)9 Muscat G.E....Kedes L. (Gene Expr. 1992)
    233. Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. (PubMed id 1398068)9 Bargonetti J....Prives C. (amp 1992)
    234. McLeod syndrome: a distinct form of neuroacanthocytosis. Report of two cases and literature review with emphasis on neuromuscular manifestations. (PubMed id 1512605)9 Witt T.N....Olsen E.G. (J. Neurol. 1992)
    235. Linkage disequilibrium detected between myotonic dystrophy and the anonymous marker D19S63 in the Spanish population. (PubMed id 1351033)9 Cobo A....Baiget M. (Hum. Genet. 1992)
    236. 3' creatine kinase (M-type) polymorphisms linked to myotonic dystrophy in Italian and Spanish populations. (PubMed id 1682233)9 Gennarelli M....Dallapiccola B. (Hum. Genet. 1991)
    237. Immunohistochemical study of childhood rhabdomyosarcomas and related neoplasms. Results of an Intergroup Rhabdomyosarcoma study project. (PubMed id 1710539)9 Parham D.M....Maurer H. (Cancer 1991)
    238. Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF4. (PubMed id 1658626)9 Chakraborty T. and Olson E.N. (Mol. Cell. Biol. 1991)
    239. Physical and genetic mapping of a novel chromosome 19 ERCC1 marker showing close linkage with myotonic dystrophy. (PubMed id 1674498)9 Shutler G....Korneluk R.G. (Genomics 1991)
    240. Isolation and characterization of an avian myogenic cell line. (PubMed id 1985013)9 Antin P.B. and Ordahl C.P. (Dev. Biol. 1991)
    241. Transforming growth factor beta represses the actions of myogenin through a mechanism independent of DNA binding. (PubMed id 1850837)9 Brennan T.J....Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    242. [Application of the polymerase chain reaction technique (PCR) to the molecular diagnosis of myotonic dystrophy]. (PubMed id 1687310)9 Cobo A.M....Baiget M. (Neurologia 1991)
    243. Linkage assignment of a DNA sequence (ERCC2L1) homologous to a human DNA repair gene in Xiphophorus fishes: implications for the evolutionary derivation of human chromosome 19. (PubMed id 1680795)9 Walter R.B....Nairn R.S. (Genomics 1991)
    244. MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation. (PubMed id 2377600)9 Weintraub H....Lassar A. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    245. Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy. (PubMed id 1975560)9 Walsh K.V....Shaw D.J. (Hum. Genet. 1990)
    246. Direct haplotyping by double digestion of PCR-amplified creatine kinase (CKMM): application to myotonic dystrophy diagnosis. (PubMed id 1980487)9 Lavedan C....Junien C. (Genomics 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1158 HGNC: 1994 AceView: CKM Ensembl:ENSG00000104879 euGenes: HUgn1158
    ECgene: CKM Kegg: 1158 H-InvDB: CKM

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CKM Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Creatine_kinase
    SeattleSNPshttp://pga.gs.washington.edu/data/ckm/
    Wikipedia http://en.wikipedia.org/wiki/CKM_(gene)

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CKM gene:
    Search GeneIP for patents involving CKM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CKM (Creatine Kinase, Muscle/CKMM)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CKM   OriGene RNAi products in human, mouse, rat for CKM  
     OriGene qPCR primer pairs and template standards for CKM   OriGene Protein Over-expression Lysate for CKM  
     OriGene MassSpec something-or-other for CKM   OriGene clones in human, mouse for CKM  
     OriGene qSTAR qPCR primer pairs in human, mouse for CKM   OriGene Purified Protein for CKM  
     OriGene ORF clones in mouse, rat for CKM   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CKM   OriGene Custom Protein Services for CKM  

     
     
     Block miRNA regulation of human, mouse, rat CKM using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CKM
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKM Predesigned siRNA for gene silencing in human, mouse, rat CKM
     QuantiFast Probe-based Assays in human, mouse, rat CKM QuantiTect SYBR Green Assays in human, mouse, rat CKM
     PCR Arrays including human, mouse, rat CKM Search Chromatin IP Primers for CKM
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKM  GeneGlobe Interaction Network for CKM
     Regulatory tfbs in CKM promoter
     GenScript Custom Purified and Recombinant Proteins Services for CKM GenScript cDNA clones with any tag delivered in your preferred vector for CKM
     GenScript Custom Assay Services for CKM GenScript Custom overexpressing Cell Line Services for CKM
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CKM (KCRM)
     Proteins for CKM
     Browse Sino Biological Cell Lysates
     cDNA Clones for CKM
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CKM antibodies
     CKM proteins
     CKM lysates
     Antibodies for CKM
     See all of Abcam's Antibodies, Kits and Proteins for CKM
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CKM
     Proteins for CKM
     Antibodies for CKM
     ELISAs for CKM
     CLIAs for CKM



     Browse ESI BIO Cell Lines and PureStem Progenitors for CKM
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM
     SwitchGear 3'UTR luciferase reporter plasmids for CKM
     SwitchGear Promoter luciferase reporter plasmids for CKM
     ThermoFisher Antibodies for CKM
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKM
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CKM
     LSBio Antibodies in human, mouse, rat for CKM
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for CKM
      Search eBioscience for proteins for CKM
      Search eBioscience for elisas for CKM
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CKM gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4