Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CKM Gene

protein-coding GIFtS: 68
GCID: GC19M045809

creatine kinase, muscle

(Previous symbol: CKMM)

Explore 39 diseases affiliated with
CKM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Creatine Kinase, Muscle¹ ²		EC 2.7.3.2³ ⁸
CKMM¹ ² ³ ⁵		Creatine Kinase M-Type²
Creatine Kinase M Chain² ³		EC 2.7.3⁸
M-CK² ³

External Ids:	HGNC: 1994¹	Entrez Gene: 1158²	Ensembl: ENSG00000104879⁷	OMIM: 123310⁵	UniProtKB: P06732³

Export aliases for CKM gene to outside databases

Previous GC identifers: GC19M046454 GC19M046200 GC19M050485 GC19M050501 GC19M042241

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKM:

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum

marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and

various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues,

and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido

phosphotransferase protein family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732

Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).

Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy

demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CKM gene promoter:
USF1 USF-1 MyoD Pax-4a Arnt Roaz
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKM promoter sequence

Search SABiosciences Chromatin IP Primers for CKM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

CKM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKM gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M045809: view genomic region (about GC identifiers)

Start:	45,809,671 bp from pter	End:	45,826,235 bp from pter
Size:	16,565 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732 (See protein sequence)

Recommended Name: Creatine kinase M-type

Size: 381 amino acids; 43101 Da

Subunit: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB

existing in myocardium, and BB existing in many tissues, especially brain

Subcellular location: Cytoplasm

1 PDB 3D structure from and Proteopedia for CKM:

1I0E (3D)

Secondary accessions: Q96QL9

Explore the universe of human proteins at neXtProt for CKM: NX_P06732

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06732

4/26 DME Specific Peptides for CKM (P06732) (see all 26)

CPSNLGT

NEEDHLR

GGDDLDP

AGDEESY

CKM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001815.2

ENSEMBL proteins:

ENSP00000221476

Reactome Protein details: P06732
Human Recombinant Protein Products for CKM:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CKM OriGene Protein Over-expression Lysate: CKM OriGene Custom Protein Services for CKM
	GenScript Custom Purified and Recombinant Proteins Services for CKM
	Novus Biologicals CKM Proteins Novus Biologicals CKM Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CKM
	Uscn Proteins for CKM

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	--
GO:0005829	cytosol	TAS	--

CKM for ontologies About GeneDecksing

CKM Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CKM (Creatine Kinase, Muscle/CKMM)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CKM
	GenScript Superior Antibodies for CKM
	Novus Biologicals CKM Antibodies
	Abcam antibodies for CKM
	Uscn Antibodies for CKM
	ThermoFisher Antibodies for CKM

Assay Products for CKM:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CKM
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CKM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CKM for domains About GeneDecksing

5 InterPro domains/families:

IPR000749 ATP-guanido_PTrfase

IPR014746 Gln_synth/guanido_kin_cat_dom

IPR022413 ATP-guanido_PTrfase_N

IPR022415 ATP-guanido_PTrfase_AS

IPR022414 ATP-guanido_PTrfase_cat

Graphical View of Domain Structure for InterPro Entry P06732

ProtoNet protein and cluster: P06732

1 Blocks protein family: IPB000749 ATP:guanido phosphotransferase

UniProtKB/Swiss-Prot: KCRM_HUMAN, P06732

Similarity: Belongs to the ATP:guanido phosphotransferase family

Similarity: Contains 1 phosphagen kinase C-terminal domain

Similarity: Contains 1 phosphagen kinase N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KCRM_HUMAN, P06732

Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).

Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy

demands, such as skeletal muscle, heart, brain and spermatozoa

Catalytic activity: ATP + creatine = ADP + phosphocreatine

Genatlas biochemistry entry for CKM:

creatine kinase,muscle

Enzyme Numbers (IUBMB): EC 2.7.3.2¹ ² EC 2.7.3²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004111	creatine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--

CKM for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CKM:

Increased viability after born

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ckm):

cardiovascular system

cellular

growth/size

homeostasis/metabolism

muscle

CKM for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CKM: Ckm^tm1Bew Ckm^tm2Bew

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CKM

miRNA Products:		OriGene 3'-UTR Clone: CKM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKM
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CKM:
		hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
		SwitchGear 3'UTR luciferase reporter plasmid: CKM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKM (see all 7) OriGene shRNA RFP: CKM OriGene siRNA: CKM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKM
		Sirion Biotech Custom design and validation of potent shRNA sequences against CKM

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CKM
			Sirion Biotech Customized adenovirus for overexpression of CKM Sirion Biotech Customized adenovirus for potent knockdown of CKM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKM (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKM (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CKM
		Search LifeMap BioReagents cell lines for CKM
		Sirion Biotech Customized stable knockdown cell line services for CKM Sirion Biotech Customized inducible knockdown cell line services for CKM Sirion Biotech Customized stable overexpressing cell line services for CKM Sirion Biotech Customized inducible overexpressing cell line services for CKM

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Arginine and proline metabolism

Arginine and proline metabolism

1.00

Urea cycle and metabolism of amino groups

0.36

creatine-phosphate biosynthesis

creatine-phosphate biosynthesis

1.00

Creatine metabolism

0.38

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

AMPK Enzyme Complex Pathway

AMPK Enzyme Complex Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CKM

AMPK Enzyme Complex Pathway

3 BioSystems Pathways for CKM

	creatine-phosphate biosynthesis
	Regulation of retinoblastoma protein
	Urea cycle and metabolism of amino groups

3 Reactome Pathways for CKM

	Creatine metabolism
	Metabolism
	Metabolism of amino acids and derivatives

2 Kegg Pathways (Kegg details for CKM):

	Arginine and proline metabolism
	Metabolic pathways

CKM for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CKM

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/18 Interacting proteins for CKM (P06732³ ENSP00000221476⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRIM63	Q969Q1³, ENSP00000363390⁴	I2D: score=2 STRING: ENSP00000363390
CKB	P12277³, ENSP00000299198⁴	I2D: score=1 STRING: ENSP00000299198
TRIM54	Q9BYV2³, ENSP00000296098⁴	I2D: score=1 STRING: ENSP00000296098
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
MYOM2	P54296³, ENSP00000262113⁴	I2D: score=1 STRING: ENSP00000262113

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006600	creatine metabolic process	TAS	--
GO:0034641	cellular nitrogen compound metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046314	phosphocreatine biosynthetic process	IEA	--

CKM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CKM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CKM

4 HMDB Compounds for CKM About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Creatine	((amino(imino)methyl)(methyl)amino)acetate (see all 17)	57-00-1	--
Phosphocreatine	Creatine phosphate (see all 15)	67-07-2	--

4 DrugBank Compounds for CKM About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(Diaminomethyl-Methyl-Amino)-Acetic Acid	--	--	target	--	17139284 17016423 10592235
Adenosine-5'-Diphosphate	--	20398-34-9	target	--	17139284 17016423 10592235
Creatine	(alpha-Methylguanido)acetic acid (see all 6)	57-00-1	target	ligand	17000714 1731757 17389266
D-Arginine	--	157-06-2	target	--	17139284 17016423 10592235

10/23 Novoseek chemical compound relationships for CKM gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
creatinine	84.5	273	19327508 (5), 9808283 (5), 1690725 (3), 9756613 (3) (see all 99)
phosphocreatine	39.7	2	18979206 (1)
glycogen	18.9	5	18560415 (2), 15922959 (1)
percoll	14.9	1	8833742 (1)
atp	12	4	9516180 (1), 1950416 (1), 18979206 (1)
pyruvate	9.82	1	9740064 (1)
chloramphenicol	5.5	1	1690725 (1)
calcium	3.94	1	15389566 (1)
oxygen	0	1	11708401 (1)
nitric oxide	0	1	8617220 (1)

Search CenterWatch for drugs/clinical trials and news about CKM / KCRM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CKM gene:

NM_001824.4

Unigene Cluster for CKM:

Creatine kinase, muscle

Hs.334347 [show with all ESTs]

Unigene Representative Sequence: NM_001824

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000221476(uc002pbd.3)

miRNA Products:		OriGene 3'-UTR Clone: CKM Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKM
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CKM:
		hsa-miR-3140-3p hsa-miR-663 hsa-miR-1908
		SwitchGear 3'UTR luciferase reporter plasmid: CKM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKM (see all 7) OriGene shRNA RFP: CKM OriGene siRNA: CKM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKM
		Sirion Biotech Custom design and validation of potent shRNA sequences against CKM

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKM (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKM (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKM (NM_001824)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CKM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKM

Additional cDNA sequence:

AK129878.1 AK300730.1 AK313281.1 BC007462.1 BT006793.1 M14780.1 M16440.1

16 DOTS entries:

DT.86999432 DT.91755914 DT.100820874 DT.121502341 DT.102828559 DT.100820873 DT.121502345 DT.100820875

DT.121502338 DT.91755923 DT.100820876 DT.100820872 DT.100820877 DT.87000155 DT.95369564 DT.100031850

24/987 AceView cDNA sequences (see all 987):

F29227 F29176 CD612932 BM874705 F31964 NM_001824 F28206 F30006

F22796 F33674 F29199 F15639 F24524 F21295 AJ573003 F36280

AA346181 F35273 AL598094 C05040 F30805 F30046 F30182 F18252

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CKM About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b
SP1:
SP2:									-		-		-		-		-		-		-
SP3:											-		-
SP4:					-

ECgene alternative splicing isoforms for CKM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CKM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCCCGCCC

About this image

CKM expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CKM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CKM

SOURCE GeneReport for Unigene cluster: Hs.334347

SABiosciences Expression via Pathway-Focused PCR Array including CKM:

Cardiotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CKM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKM

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKM gene from 21 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	CKM¹	creatine kinase, muscle	99.39(n) 100(a)		744935 XM_001163660.3 XP_001163660.2
mouse (Mus musculus)	Mammalia	Ckm^{1 , 5}	creatine kinase, muscle^{1, 5}	90.29(n)¹ 96.59(a)¹		7 (9.67 cM)⁵ 12715¹ NM_007710.2¹ NP_031736.1¹ 19411094⁵
rat (Rattus norvegicus)	Mammalia	Ckm¹	creatine kinase, muscle	89.5(n) 96.06(a)		24265 NM_012530.1 NP_036662.1
cow (Bos taurus)	Mammalia	CKM¹	creatine kinase, muscle	91.95(n) 96.59(a)		286822 NM_174773.3 NP_777198.2
dog (Canis familiaris)	Mammalia	CKM¹	creatine kinase, muscle	91.6(n) 96.33(a)		476435 XM_533641.4 XP_533641.3
oppossum (Monodelphis domestica)	Mammalia	CD151⁶ --	Uncharacterized protein	52(a) 19(a)	1 ↔ 1 possible ortholog	Un(45170462-45383182) 3(331504439-331602452)
platypus (Ornithorhynchus anatinus)	Mammalia	CKM⁶	Uncharacterized protein	94(a)	1 ↔ 1	Contig22603(4588-8886)
chicken (Gallus gallus)	Aves	CKM¹	creatine kinase, muscle	81.45(n) 90.29(a)		396507 NM_205507.1 NP_990838.1
lizard (Anolis carolinensis)	Reptilia	CKM⁶	--	93(a)	1 ↔ 1	GL344965.1(1197-12094)
African clawed frog (Xenopus laevis)	Amphibia	ckm-prov²	creatine kinase, muscle	80.36(n)		BC042249.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	MGC75682²	hypothetical protein MGC75682	79.73(n)		BC064186.1
zebrafish (Danio rerio)	Actinopterygii	ckm²	creatine kinase, muscle	82.81(n)		30095 BC056706.1
sea squirt (Ciona savignyi)	Ascidiacea	-- -- (see all 3)	--	68(a) 65(a) (see all 3)	many ↔ many many ↔ many (see all 3)	reftig_1(2352274-2357788) reftig_21(576591-580721)
sea urchin (Strongylocentrotus purpuratus)	Echinoidea	-- -- (see all 5)	--	7(a) 6(a) (see all 5)	possible ortholog possible ortholog (see all 5)	scaffold_158(537661-541724) scaffold_158(539775-939598)
fruit fly (Drosophila melanogaster)	Insecta	Argk³	phosphorylation arginine kinase	39(a) (best of 3)		--
honey bee (Apis mellifera)	Insecta	ARGK⁶ -- (see all 3)	--	33(a) 29(a) (see all 3)	possible ortholog possible ortholog (see all 3)	GroupUn.30(54475-55855) Group1.15(200418-213413)
worm (Caenorhabditis elegans)	Secernentea	ZC434.8³	arginine kinase	39(a) (best of 4)		I(10356154-10357374) --
schistosome parasite (Schistosoma mansoni)	Trematoda	Smp_194770⁶	Taurocyamine kinase	14(a)	possible ortholog	Smp_scaff019022(337842-362310)
common water flea (Daphnia pulex)	Crustacea	--	--	32(a)	possible ortholog	scaffold_3(183400-186200)
sea anemone (Nematostella vectensis)	Anthozoa	-- -- (see all 10)	--	71(a) 55(a) (see all 10)	possible ortholog many ↔ many (see all 10)	scaffold_23(1197477-1199728) scaffold_57(1061828-1071067)
Chromalveolata (Phytophthora infestans)	Oomycota	PITG_11046⁶ PITG_13551⁶	Creatine kinase, mitochondrial	31(a) 21(a)	many ↔ many many ↔ many	supercont1.19(899596-901875) supercont1.29(878696-881160)

Species with no ortholog for CKM

ENSEMBL Gene Tree for CKM (if available)
TreeFam Gene Tree for CKM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CKM gene

CKB² CKMT1B² CKMT2² CKMT1A²

4 SIMAP similar genes for CKM using alignment to 1 protein entry: KCRM_HUMAN:

CKB CKMT2 CKMT1B CKMT1A

CKM for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8111989^1,2	C,F,A,H	--	45809208(+)	`AGCCAT/CGGCAG`	1	--	int¹		29		NS EA NA WA CSA	3084
rs17875631^1,2	C	--	45809265(-)	`GTCCCG/ATCTGA`	1	--	int¹		2		NS	80
rs189610964^1,2		--	45809333(+)	`CTCAAA/CACTGG`	1	--	int¹		0	--	--	--	--
rs17875630^1,2	C,F	--	45809344(-)	`CCCAAC/TGGTCT`	1	--	int¹		4		NS WA	200
rs181668808^1,2		--	45809554(+)	`AACTTA/TGCCTC`	1	--	int¹		0	--	--	--	--
rs111843749^1,2	C	--	45809672(+)	`AAGCTT/AAGGCC`	1	--	ut3¹		1		CSA	1
rs75379365^1,2		--	45809685(+)	`CAATGC/TTTTTA`	1	--	ut3¹		1		NA	120
rs186189112^1,2		--	45809697(+)	`TTATCA/GCTTTG`	1	--	ut3¹		0	--	--	--	--
rs17875629^1,2	C,F,H	--	45809750(-)	`TCTAGT/CTAATG`	1	--	ut3¹ ese³		14		NS NA WA	1526
rs17875628^1,2	C,F	--	45809886(-)	`CTCTCT/CCCACC`	1	--	ut3¹ ese³		4		NS WA	210

HapMap Linkage Disequilibrium report for CKM (45809671 - 45826235 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CKM: --
Human Gene Mutation Database (HGMD): CKM

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKM

DNA2.0 Custom Variant and Variant Library Synthesis for CKM

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CKM for disorders           About GeneDecksing

OMIM gene information: 123310    OMIM disorders: --

20/39 diseases for CKM (see all 39):    About MalaCards

myocardial infarction myoadenylate deaminase deficiency subvalvular aortic stenosis retinol binding protein

creatine phosphokinase muscular dystrophy dengue hemorrhagic fever duchenne muscular dystrophy

acute myocardial infarction myotonic dystrophy glycogen storage disease hemorrhagic fever

glucose intolerance amyotrophic lateral sclerosis urolithiasis mcleod syndrome

heart block ischemic heart disease oral squamous cell carcinoma lateral sclerosis

2 diseases from the University of Copenhagen DISEASES database for CKM:

Myocardial infarction Myopathy

10/15 Novoseek disease relationships for CKM gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myotonic dystrophy	75.8	19	2016086 (2), 2320244 (1), 1971149 (1), 2300239 (1) (see all 14)
muscular dystrophies	53.9	2	12609502 (1), 11287429 (1)
muscular dystrophy duchenne	37	1	9274724 (1)
rhabdomyolysis	22.1	1	9522498 (1)
ureteral stone	19.6	2	1921018 (1), 1413305 (1)
acute myocardial infarction	14.4	1	7656437 (1)
urolithiasis	14.1	2	1921018 (1), 1413305 (1)
myositis	9.45	1	1370861 (1)
renal stone	7.03	2	1921018 (1), 1413305 (1)
necrosis	3.86	1	8617220 (1)

Genetic Association Database (GAD): CKM
Human Genome Epidemiology (HuGE) Navigator: CKM (13 documents)

Export disorders for CKM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CKM gene, integrated from 9 sources (see all 246):
(articles sorted by number of sources associating them with CKM)

Utopia: connect your pdf to the dynamic
world of online information

Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-week races? (PubMed id 16037885)^{1, 4, 9} Lucia A....Earnest C.P. (2005)
Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme. (PubMed id 17000714)^{1, 7, 9} Zhou D.Q....Wen L. (2006)
Muscle creatine kinase isoenzyme expression in adult human brain. (PubMed id 1690725)^{1, 2, 9} Hamburg R.J.... Perryman M.B. (1990)
[An A/G polymorphism in muscle-specific creatine kinase gene in Han population in Northern China] (PubMed id 16120572)^{1, 4, 9} Zhou D.Q....Gong L. (2005)
The caregene study: muscle-specific creatine kinase gene and aerobic power in coronary artery disease. (PubMed id 16079652)^{1, 4, 9} Defoor J....Vanhees L. (2005)
Crystallization and preliminary X-ray analysis of human muscle creatine kinase. (PubMed id 10089465)^{1, 2, 9} Tang L.... Lin Z.J. (1999)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Developmental regulation and tissue-specific expression of the human muscle creatine kinase gene. (PubMed id 2903158)^{1, 2} Trask R.V.... Billadello J.J. (1988)
cDNA cloning and mapping of the human creatine kinase M gene to 19q13. (PubMed id 3031982)^{1, 2} Nigro J.M....Martin-Deleon P. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1158	HGNC: 1994	AceView: CKM	Ensembl:ENSG00000104879	euGenes: HUgn1158
ECgene: CKM	Kegg: 1158	H-InvDB: CKM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CKM	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Creatine_kinase
SeattleSNPs	http://pga.gs.washington.edu/data/ckm/
Wikipedia	http://en.wikipedia.org/wiki/CKM_(gene)

Intellectual Property for CKM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CKM gene:
Search GeneIP for patents involving CKM

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CKM (Creatine Kinase, Muscle/CKMM)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CKM
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKM		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKM
	OriGene Protein Over-expression Lysate for CKM		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CKM		OriGene 3'-UTR Clone for CKM
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKM		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKM
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CKM		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CKM		OriGene Custom Protein Services for CKM
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CKM
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKM
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKM
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKM
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKM
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKM

	GenScript Custom Purified and Recombinant Proteins Services for CKM		GenScript cDNA clones with any tag delivered in your preferred vector for CKM
	GenScript Custom Assay Services for CKM		GenScript Superior Antibodies for CKM
	GenScript Custom overexpressing Cell Line Services for CKM		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CKM promoter
	Search Chromatin IP Primers for CKM
	RT² qPCR Primer Assay in human, mouse, rat CKM
	GNC Network for CKM
	SABiosciences PCR Arrays including human, mouse, rat CKM

Search Tocris compounds for CKM

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CKM antibodies
	CKM proteins
	CKM lysates

	Antibodies for CKM
	See all of Abcam's Antibodies, Kits and Proteins for CKM
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CKM

CKM Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CKM

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKM

	SwitchGear 3'UTR luciferase reporter plasmids for CKM
	SwitchGear Promoter luciferase reporter plasmids for CKM

ThermoFisher Antibodies for CKM

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKM

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CKM

Sirion Biotech Customized:

	stable knockdown cell line services for CKM
	inducible knockdown cell line services for CKM
	design and validation of potent shRNA sequences against CKM
	adenovirus for potent knockdown of CKM
	adenovirus for overexpression of CKM
	stable overexpressing cell line services for CKM
	inducible overexpressing cell line services for CKM

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CKM gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CKM Gene

creatine kinase, muscle

Aliases
for CKM gene

Summaries
for CKM gene

Genomic Views
for CKM gene

Proteins
for CKM gene

Protein Domains /
Families
for CKM gene

Function
for CKM gene

Pathways & Interactions
for CKM gene

Drugs & Compounds
for CKM gene

Transcripts
for CKM gene

Expression
for CKM gene

Orthologs
for CKM gene

Paralogs
for CKM gene

Genomic Variants
for CKM gene

Disorders / Diseases
for CKM gene

Publications
for CKM gene

External Searches for CKM gene

Genome Databases showing CKM gene

Other Databases showing CKM gene

Specialized Databases showing CKM gene

Intellectual Property
for CKM gene

Products
for CKM gene

View Random Gene

Advanced Search

Export list of displayed genes

CKM Gene

creatine kinase, muscle

Aliasesfor CKM gene

Summariesfor CKM gene

Genomic Viewsfor CKM gene

Proteinsfor CKM gene

Protein Domains /Familiesfor CKM gene

Functionfor CKM gene

Pathways & Interactionsfor CKM gene

Drugs & Compoundsfor CKM gene

Transcriptsfor CKM gene

Expression for CKM gene

Orthologsfor CKM gene

Paralogsfor CKM gene

Genomic Variantsfor CKM gene

Disorders / Diseasesfor CKM gene

Publicationsfor CKM gene

External Searches for CKM gene

Genome Databases showing CKM gene

Other Databases showing CKM gene

Specialized Databases showing CKM gene

Intellectual Propertyfor CKM gene

Productsfor CKM gene

View Random Gene

Aliases
for CKM gene

Summaries
for CKM gene

Genomic Views
for CKM gene

Proteins
for CKM gene

Protein Domains /
Families
for CKM gene

Function
for CKM gene

Pathways & Interactions
for CKM gene

Drugs & Compounds
for CKM gene

Transcripts
for CKM gene

Expression
for CKM gene

Orthologs
for CKM gene

Paralogs
for CKM gene

Genomic Variants
for CKM gene

Disorders / Diseases
for CKM gene

Publications
for CKM gene

Intellectual Property
for CKM gene

Products
for CKM gene