Aliases for CKM Gene
External Ids for CKM Gene
Previous HGNC Symbols for CKM Gene
Previous GeneCards Identifiers for CKM Gene
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
GeneCards Summary for CKM Gene
CKM (Creatine Kinase, M-Type) is a Protein Coding gene. Diseases associated with CKM include Prostate Rhabdomyosarcoma and Dressler's Syndrome. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and creatine kinase activity. An important paralog of this gene is CKB.
UniProtKB/Swiss-Prot for CKM Gene
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.