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Aliases for CKM Gene

Aliases for CKM Gene

  • Creatine Kinase, Muscle 2 3
  • CKMM 3 4 6
  • Creatine Kinase M Chain 3 4
  • EC 2.7.3.2 4 63
  • M-CK 3 4
  • Creatine Kinase M-Type 3
  • EC 2.7.3 63

External Ids for CKM Gene

Previous HGNC Symbols for CKM Gene

  • CKMM

Previous GeneCards Identifiers for CKM Gene

  • GC19M046454
  • GC19M046200
  • GC19M050485
  • GC19M050501
  • GC19M045809
  • GC19M042241

Summaries for CKM Gene

Entrez Gene Summary for CKM Gene

  • The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKM Gene

CKM (Creatine Kinase, Muscle) is a Protein Coding gene. Diseases associated with CKM include hemophilia b and myocardial infarction. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKB.

UniProtKB/Swiss-Prot for CKM Gene

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Gene Wiki entry for CKM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKM Gene

Genomics for CKM Gene

Regulatory Elements for CKM Gene

Genomic Location for CKM Gene

Start:
45,306,413 bp from pter
End:
45,323,044 bp from pter
Size:
16,632 bases
Orientation:
Minus strand

Genomic View for CKM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKM Gene

Proteins for CKM Gene

  • Protein details for CKM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06732-KCRM_HUMAN
    Recommended name:
    Creatine kinase M-type
    Protein Accession:
    P06732
    Secondary Accessions:
    • Q96QL9

    Protein attributes for CKM Gene

    Size:
    381 amino acids
    Molecular mass:
    43101 Da
    Quaternary structure:
    • Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain

    Three dimensional structures from OCA and Proteopedia for CKM Gene

neXtProt entry for CKM Gene

Proteomics data for CKM Gene at MOPED

Post-translational modifications for CKM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CKM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CKM ("Creatine Kinase, Muscle/CKMM")

Domains for CKM Gene

Suggested Antigen Peptide Sequences for CKM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06732

UniProtKB/Swiss-Prot:

KCRM_HUMAN :
  • P06732
Domain:
  • Contains 1 phosphagen kinase C-terminal domain.
  • Contains 1 phosphagen kinase N-terminal domain.
Family:
  • Belongs to the ATP:guanido phosphotransferase family.
genes like me logo Genes that share domains with CKM: view

No data available for Gene Families for CKM Gene

Function for CKM Gene

Molecular function for CKM Gene

GENATLAS Biochemistry: creatine kinase,muscle
UniProtKB/Swiss-Prot CatalyticActivity: ATP + creatine = ADP + phosphocreatine.
UniProtKB/Swiss-Prot Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Enzyme Numbers (IUBMB) for CKM Gene

Gene Ontology (GO) - Molecular Function for CKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004111 creatine kinase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CKM: view
genes like me logo Genes that share phenotypes with CKM: view

Animal Models for CKM Gene

MGI Knock Outs for CKM:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CKM Gene

Localization for CKM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKM Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKM Gene COMPARTMENTS Subcellular localization image for CKM gene
Compartment Confidence
cytosol 4
cytoskeleton 2
mitochondrion 2
nucleus 2
plasma membrane 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CKM: view

Pathways for CKM Gene

genes like me logo Genes that share pathways with CKM: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006600 creatine metabolic process TAS --
GO:0016310 phosphorylation IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046314 phosphocreatine biosynthetic process IEA --
genes like me logo Genes that share ontologies with CKM: view

Compounds for CKM Gene

(4) HMDB Compounds for CKM Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Creatine
  • ((amino(imino)methyl)(methyl)amino)acetate
57-00-1
Phosphocreatine
  • Creatine phosphate
67-07-2

(4) Drugbank Compounds for CKM Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(Diaminomethyl-Methyl-Amino)-Acetic Acid
target
Adenosine-5'-Diphosphate
20398-34-9 target
Creatine
  • (alpha-Methylguanido)acetic acid
57-00-1 target ligand
D-Arginine
157-06-2 target

(23) Novoseek inferred chemical compound relationships for CKM Gene

Compound -log(P) Hits PubMed IDs
creatinine 84.5 139
phosphocreatine 39.7 1
glycogen 18.9 3
percoll 14.9 1
atp 12 3
genes like me logo Genes that share compounds with CKM: view

Transcripts for CKM Gene

mRNA/cDNA for CKM Gene

(987) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CKM Gene

Creatine kinase, muscle:
Representative Sequences:

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKM Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1:
SP2: - - - - - - -
SP3: - -
SP4: -

Relevant External Links for CKM Gene

GeneLoc Exon Structure for
CKM
ECgene alternative splicing isoforms for
CKM

Expression for CKM Gene

mRNA expression in normal human tissues for CKM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKM Gene

This gene is overexpressed in Muscle - Skeletal (41.3) and Heart - Left Ventricle (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CKM Gene

SOURCE GeneReport for Unigene cluster for CKM Gene Hs.334347

genes like me logo Genes that share expressions with CKM: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CKM Gene

Orthologs for CKM Gene

This gene was present in the common ancestor of animals.

Orthologs for CKM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKM 35
  • 99.39 (n)
  • 100 (a)
CKM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CKM 35
  • 91.95 (n)
  • 96.59 (a)
CKM 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKM 35
  • 91.6 (n)
  • 96.33 (a)
CKM 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ckm 35
  • 90.29 (n)
  • 96.59 (a)
Ckm 16
Ckm 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CKM 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CKM 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ckm 35
  • 89.5 (n)
  • 96.06 (a)
chicken
(Gallus gallus)
Aves CKM 35
  • 81.45 (n)
  • 90.29 (a)
lizard
(Anolis carolinensis)
Reptilia CKM 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ckm-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ckm 35
  • 78.92 (n)
  • 87.93 (a)
MGC75682 35
zebrafish
(Danio rerio)
Actinopterygii ckm 35
ckma 35
  • 80.66 (n)
  • 88.71 (a)
ckma 36
  • 88 (a)
OneToMany
ckmb 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Argk 36
  • 27 (a)
ManyToMany
CG30274 36
  • 18 (a)
ManyToMany
CG4546 36
  • 26 (a)
ManyToMany
CG5144 36
  • 36 (a)
ManyToMany
CG5144 37
  • 38 (a)
CG4546 37
  • 32 (a)
Argk 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea F11G11.13 36
  • 32 (a)
ManyToMany
F32B5.1 36
  • 34 (a)
ManyToMany
F44G3.2 36
  • 37 (a)
ManyToMany
F46H5.3 36
  • 37 (a)
ManyToMany
W10C8.5 36
  • 36 (a)
ManyToMany
ZC434.8 36
  • 40 (a)
ManyToMany
ZC434.8 37
  • 39 (a)
W10C8.5 37
  • 38 (a)
F32B5.1 37
  • 38 (a)
F44G3.2 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
ManyToMany
CSA.6164 36
  • 68 (a)
ManyToMany
Species with no ortholog for CKM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKM Gene

ENSEMBL:
Gene Tree for CKM (if available)
TreeFam:
Gene Tree for CKM (if available)

Paralogs for CKM Gene

Paralogs for CKM Gene

Selected SIMAP similar genes for CKM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CKM: view

Variants for CKM Gene

Sequence variations from dbSNP and Humsavar for CKM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4884 -- 45,306,777(-) TCCAT(C/T)GACGA synonymous-codon, reference
rs8188 -- 45,306,654(-) CCCTG(G/T)CCCAG utr-variant-3-prime
rs9976 -- 45,306,542(-) TCCCT(A/G)GCAGG utr-variant-3-prime
rs344793 -- 45,310,573(+) taaag(C/T)tagta intron-variant
rs344794 -- 45,308,843(+) CTTGG(A/T)AATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CKM Gene

Variant ID Type Subtype PubMed ID
nsv833844 CNV Loss 17160897
nsv912145 CNV Loss 21882294
nsv912146 CNV Loss 21882294
nsv833845 CNV Loss 17160897
esv2660204 CNV Deletion 23128226
nsv912147 CNV Loss 21882294
dgv3951n71 CNV Loss 21882294
nsv912150 CNV Gain 21882294
nsv912151 CNV Loss 21882294
dgv3952n71 CNV Gain 21882294

Relevant External Links for CKM Gene

HapMap Linkage Disequilibrium report
CKM
Human Gene Mutation Database (HGMD)
CKM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKM Gene

Disorders for CKM Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CKM Gene including...

Search for CKM Gene in MalaCards »

(2) University of Copenhagen DISEASES for CKM Gene

(15) Novoseek inferred disease relationships for CKM Gene

Disease -log(P) Hits PubMed IDs
myotonic dystrophy 75.8 15
muscular dystrophies 53.9 2
muscular dystrophy duchenne 37 1
rhabdomyolysis 22.1 1
ureteral stone 19.6 2

Relevant External Links for CKM

Genetic Association Database (GAD)
CKM
Human Genome Epidemiology (HuGE) Navigator
CKM
genes like me logo Genes that share disorders with CKM: view

No data available for UniProtKB/Swiss-Prot for CKM Gene

Publications for CKM Gene

  1. Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme. (PMID: 17000714) Zhou D.Q. … Wen L. (Br J Sports Med 2006) 3 23 25 48
  2. Muscle creatine kinase isoenzyme expression in adult human brain. (PMID: 1690725) Hamburg R.J. … Perryman M.B. (J. Biol. Chem. 1990) 3 4 23
  3. Crystallization and preliminary X-ray analysis of human muscle creatine kinase. (PMID: 10089465) Tang L. … Lin Z.J. (Acta Crystallogr. D 1999) 3 4 23
  4. Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-week races? (PMID: 16037885) LucA-a A. … Earnest C.P. (Int J Sports Med 2005) 3 23 48
  5. The caregene study: muscle-specific creatine kinase gene and aerobic power in coronary artery disease. (PMID: 16079652) Defoor J. … Vanhees L. (Eur J Cardiovasc Prev Rehabil 2005) 3 23 48

Products for CKM Gene

  • Addgene plasmids for CKM

Sources for CKM Gene

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