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Aliases for CKLF-CMTM1 Gene

Aliases for CKLF-CMTM1 Gene

  • CKLF-CMTM1 Readthrough 2 3 5

External Ids for CKLF-CMTM1 Gene

Previous GeneCards Identifiers for CKLF-CMTM1 Gene

  • GC16U901323
  • GC16P066588
  • GC16P066589
  • GC16P066593
  • GC16P066597
  • GC16P066602

Summaries for CKLF-CMTM1 Gene

Entrez Gene Summary for CKLF-CMTM1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring CKLF (chemokine-like factor) and CMTM1 (CKLF-like MARVEL transmembrane domain containing 1) genes on chromosome 16. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for CKLF-CMTM1 Gene

CKLF-CMTM1 (CKLF-CMTM1 Readthrough) is a Protein Coding gene. An important paralog of this gene is CMTM1.

Additional gene information for CKLF-CMTM1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKLF-CMTM1 Gene

Genomics for CKLF-CMTM1 Gene

GeneHancer (GH) Regulatory Elements for CKLF-CMTM1 Gene

Promoters and enhancers for CKLF-CMTM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I066547 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.5 -1512 6.6 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 SP3 NFYC TK2 CKLF CKLF-CMTM1 ENSG00000275745 PIR51465 PIR54425 ENSG00000261519 NAE1 ZDHHC1 BEAN1
GH16I066515 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -31.3 -31339 12.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 IRF4 TK2 CKLF ENSG00000260465 ZDHHC1 NAE1 BEAN1 CKLF-CMTM1 E2F4 CMTM2 PLEKHG4
GH16I066502 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -49.8 -49799 1.2 ELF3 RAD21 RARA ETS1 YY1 ZNF366 ATF7 THAP11 RXRA CEBPB TK2 E2F4 CKLF-CMTM1 CKLF ENSG00000260465 CES3 ENSG00000260755 ENSG00000260851 GC16P066491
GH16I066510 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.2 -40.4 -40396 3.8 PKNOX1 FOXA2 ARID4B SIN3A ETS1 TCF12 ELK1 ATF7 FOS RXRA GC16M066512 PIR49300 PIR55233 BEAN1 TK2 BEAN1-AS1 CKLF CKLF-CMTM1 CMTM2 CES4A
GH16I066507 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 -44.0 -44031 1.5 PKNOX1 JUN MAX EBF1 BATF RAD21 RFX5 GATA3 SMC3 RCOR1 PIR59655 ENSG00000260755 BEAN1 TK2 CKLF-CMTM1 CKLF ENSG00000260851 GC16P066491
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CKLF-CMTM1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CKLF-CMTM1 Gene

Genomic Locations for CKLF-CMTM1 Gene
chr16:66,552,563-66,579,135
(GRCh38/hg38)
Size:
26,573 bases
Orientation:
Plus strand
chr16:66,586,466-66,613,038
(GRCh37/hg19)

Genomic View for CKLF-CMTM1 Gene

Genes around CKLF-CMTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKLF-CMTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKLF-CMTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKLF-CMTM1 Gene

Proteins for CKLF-CMTM1 Gene

  • Protein details for CKLF-CMTM1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WVB3
    Recommended name:
    CKLF-CMTM1 readthrough
    Protein Accession:
    A0A087WVB3

    Protein attributes for CKLF-CMTM1 Gene

    Size:
    168 amino acids
    Molecular mass:
    19099 Da
    Quaternary structure:
    No Data Available
  • Protein details for CKLF-CMTM1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087X286
    Recommended name:
    CKLF-CMTM1 readthrough
    Protein Accession:
    A0A087X286

    Protein attributes for CKLF-CMTM1 Gene

    Size:
    92 amino acids
    Molecular mass:
    10176 Da
    Quaternary structure:
    No Data Available
  • Protein details for CKLF-CMTM1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PIV8
    Recommended name:
    CKLF-CMTM1 readthrough
    Protein Accession:
    E9PIV8

    Protein attributes for CKLF-CMTM1 Gene

    Size:
    60 amino acids
    Molecular mass:
    6641 Da
    Quaternary structure:
    No Data Available
  • Protein details for CKLF-CMTM1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PLU7
    Recommended name:
    CKLF-CMTM1 readthrough
    Protein Accession:
    E9PLU7

    Protein attributes for CKLF-CMTM1 Gene

    Size:
    33 amino acids
    Molecular mass:
    3940 Da
    Quaternary structure:
    No Data Available
  • Protein details for CKLF-CMTM1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PSG2
    Recommended name:
    CKLF-CMTM1 readthrough
    Protein Accession:
    E9PSG2

    Protein attributes for CKLF-CMTM1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12852 Da
    Quaternary structure:
    No Data Available
  • Protein details for CKLF-CMTM1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YDF2
    Recommended name:
    CKLF-CMTM1 readthrough
    Protein Accession:
    H0YDF2

    Protein attributes for CKLF-CMTM1 Gene

    Size:
    64 amino acids
    Molecular mass:
    6856 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CKLF-CMTM1 Gene

Post-translational modifications for CKLF-CMTM1 Gene

No Post-translational modifications

Other Protein References for CKLF-CMTM1 Gene

No data available for DME Specific Peptides for CKLF-CMTM1 Gene

Domains & Families for CKLF-CMTM1 Gene

Gene Families for CKLF-CMTM1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CKLF-CMTM1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CKLF-CMTM1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CKLF-CMTM1 Gene

Function for CKLF-CMTM1 Gene

Phenotypes From GWAS Catalog for CKLF-CMTM1 Gene

Phenotypes for CKLF-CMTM1 Gene

genes like me logo Genes that share phenotypes with CKLF-CMTM1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CKLF-CMTM1 Gene

Localization for CKLF-CMTM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKLF-CMTM1 gene
Compartment Confidence
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CKLF-CMTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CKLF-CMTM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CKLF-CMTM1 Gene

Pathways & Interactions for CKLF-CMTM1 Gene

SuperPathways for CKLF-CMTM1 Gene

No Data Available

Interacting Proteins for CKLF-CMTM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000433998%0d%0a9606.ENSP00000224337%0d%0a9606.ENSP00000219919%0d%0a
Selected Interacting proteins: ENSP00000433998 for CKLF-CMTM1 Gene via STRING

Gene Ontology (GO) - Biological Process for CKLF-CMTM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CKLF-CMTM1 Gene

Drugs & Compounds for CKLF-CMTM1 Gene

No Compound Related Data Available

Transcripts for CKLF-CMTM1 Gene

mRNA/cDNA for CKLF-CMTM1 Gene

(3) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKLF-CMTM1 Gene

No ASD Table

Relevant External Links for CKLF-CMTM1 Gene

GeneLoc Exon Structure for
CKLF-CMTM1
ECgene alternative splicing isoforms for
CKLF-CMTM1

Expression for CKLF-CMTM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CKLF-CMTM1 Gene

genes like me logo Genes that share expression patterns with CKLF-CMTM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKLF-CMTM1 Gene

Orthologs for CKLF-CMTM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CKLF-CMTM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 34 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 17 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CMTM1 34
  • 13 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cmtm1 34
  • 10 (a)
OneToMany
Species where no ortholog for CKLF-CMTM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKLF-CMTM1 Gene

ENSEMBL:
Gene Tree for CKLF-CMTM1 (if available)
TreeFam:
Gene Tree for CKLF-CMTM1 (if available)

Paralogs for CKLF-CMTM1 Gene

Paralogs for CKLF-CMTM1 Gene

(2) SIMAP similar genes for CKLF-CMTM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CKLF-CMTM1: view

Variants for CKLF-CMTM1 Gene

Sequence variations from dbSNP and Humsavar for CKLF-CMTM1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000154538 -- 66,574,882(+) C/G/T intron_variant
rs1000211221 -- 66,567,241(+) G/A intron_variant
rs1000214068 -- 66,573,258(+) T/A intron_variant
rs1000334257 -- 66,575,868(+) C/ intron_variant
rs1000375684 -- 66,560,839(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CKLF-CMTM1 Gene

Variant ID Type Subtype PubMed ID
dgv123n111 CNV duplication 26073780
esv3638871 CNV gain 21293372
nsv472890 CNV novel sequence insertion 20440878

Variation tolerance for CKLF-CMTM1 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CKLF-CMTM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKLF-CMTM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKLF-CMTM1 Gene

Disorders for CKLF-CMTM1 Gene

Additional Disease Information for CKLF-CMTM1

No disorders were found for CKLF-CMTM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKLF-CMTM1 Gene

Publications for CKLF-CMTM1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for CKLF-CMTM1 Gene

Sources for CKLF-CMTM1 Gene

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