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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKLF Gene

protein-coding   GIFtS: 47
GCID: GC16P066586

Chemokine-Like Factor

(Previous name: chemokine-like factor 1)
(Previous symbol: CKLF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine-Like Factor1 2     CKLF42
CKLF11 2 3     UCK-12
Chemokine-Like Factor 11 2     Chemokine-Like Factor 22
C322 3     Chemokine-Like Factor 32
CKLF22     Chemokine-Like Factor 42
CKLF32     Transmembrane Proteolipid2

External Ids:    HGNC: 132531   Entrez Gene: 511922   Ensembl: ENSG000002175557   UniProtKB: Q9UBR53   

Export aliases for CKLF gene to outside databases

Previous GC identifers: GC16P066964 GC16P066321 GC16P066362 GC16P065143 GC16P052462


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKLF Gene:
The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and
inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on
chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and
lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important
roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants
encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between
this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).(provided by
RefSeq, Feb 2011)

GeneCards Summary for CKLF Gene: 
CKLF (chemokine-like factor) is a protein-coding gene. Diseases associated with CKLF include ovarian cystadenoma, and cystadenoma. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CMTM1.

UniProtKB/Swiss-Prot: CKLF_HUMAN, Q9UBR5
Function: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by
interleukin 10
Function: Isoform 1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes

Gene Wiki entry for CKLF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKLF gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKLF promoter sequence
   Search SABiosciences Chromatin IP Primers for CKLF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKLF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q22.1-q22.3

CKLF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKLF gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066586:  view genomic region     (about GC identifiers)

Start:
66,586,466 bp from pter      End:
66,600,331 bp from pter
Size:
13,866 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CKLF_HUMAN, Q9UBR5 (See protein sequence)
Recommended Name: Chemokine-like factor  
Size: 152 amino acids; 17170 Da
Subcellular location: Isoform 1: Secreted
Subcellular location: Isoform 2: Membrane; Multi-pass membrane protein (Potential)
Subcellular location: Isoform 4: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: C9JE38 Q9UHM7 Q9UHN8 Q9UI41
Alternative splicing: 5 isoforms:  Q9UBR5-1   Q9UBR5-2   Q9UBR5-3   Q9UBR5-4   Q9UBR5-5   

Explore the universe of human proteins at neXtProt for CKLF: NX_Q9UBR5

Explore proteomics data for CKLF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBR5

  • CKLF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CKLF Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001035228.1  NP_057410.1  NP_058647.1  NP_857591.1  NP_857592.1  

    ENSEMBL proteins: 
     ENSP00000431270   ENSP00000264001   ENSP00000264003   ENSP00000290771   ENSP00000355417  
     ENSP00000416678   ENSP00000433857  

    Human Recombinant Protein Products for CKLF: 
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    Novus Biologicals CKLF Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CKLF 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11415443
    GO:0005615extracellular space IEA--
    GO:0016021integral to membrane IDA11415443

    CKLF for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CKLF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q9UBR5

    ProtoNet protein and cluster: Q9UBR5

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: CKLF_HUMAN, Q9UBR5
    Similarity: Belongs to the chemokine-like factor family
    Similarity: Contains 1 MARVEL domain


    CKLF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CKLF_HUMAN, Q9UBR5
    Function: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by
    interleukin 10
    Function: Isoform 1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA11415443
         
    CKLF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CKLF:
     Decreased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CKLF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CKLF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKLF 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CKLF:
    hsa-miR-3163
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKLF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CKLF

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008283cell proliferation IDA11415443
    GO:0030593neutrophil chemotaxis IDA11415443
    GO:0030595leukocyte chemotaxis ----
    GO:0032940secretion by cell IDA11415443
    GO:0048246macrophage chemotaxis IDA11415443

    CKLF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CKLF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKLF

    1 Novoseek inferred chemical compound relationship for CKLF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 77.4 5 16137713 (2)

    Search CenterWatch for drugs/clinical trials and news about CKLF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CKLF gene (6 alternative transcripts): 
    NM_001040138.2  NM_016326.3  NM_016951.3  NM_181640.2  NM_181641.2  NM_001040139.1  

    Unigene Cluster for CKLF:

    Chemokine-like factor
    Hs.15159  [show with all ESTs]
    Unigene Representative Sequence: AK126041
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534692 ENST00000264001(uc002eow.3 uc002eou.3 uc002eot.3 uc002eov.3)
    ENST00000351137 ENST00000345436 ENST00000362093 ENST00000526149 ENST00000417030(uc002eox.2)
    ENST00000532838 ENST00000563092
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CKLF:
    hsa-miR-3163
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    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKLF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKLF

    Additional mRNA sequence: 

    AF057306.1 AF096895.2 AF135380.2 AF135381.2 AF145216.2 AF151058.1 AK126041.1 AK290307.1 
    AK301240.1 AY358999.1 BC004380.1 BC028676.1 BC091478.1 

    16 DOTS entries:

    DT.100866960  DT.100025938  DT.415915  DT.100754363  DT.97839329  DT.120724950  DT.91914577  DT.120725002 
    DT.75119879  DT.120725027  DT.120724958  DT.120724970  DT.120725032  DT.120725010  DT.75197958  DT.95260932 

    24/231 AceView cDNA sequences (see all 231):

    NM_181288 NM_181292 AK126041 AI633679 NM_181268 AY174136 AA338760 AA876539 
    NM_181269 NM_181297 BQ613826 BU077917 NM_181272 AI968172 NM_016951 BM929895 
    BM684328 AJ712987 BF475590 CK905868 BC004380 NM_052999 NM_181283 AY358999 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKLF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAAAGA
    CKLF Expression
    About this image


    See CKLF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKLF

    SOURCE GeneReport for Unigene cluster: Hs.15159

    UniProtKB/Swiss-Prot: CKLF_HUMAN, Q9UBR5
    Tissue specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen,
    lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus
    and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and
    liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including CKLF: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKLF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CKLF gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cklf1 , 5 chemokine-like factor1, 5 74.38(n)1
    59.86(a)1
      8 (53.04 cM)5
    754581  NM_029295.21  NP_083571.11 
     1042509035 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    34(a)
    1 → many
    11(10903706-10906364)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    30(a)
    1 → many
    GL343295.1(60779-70851)


    ENSEMBL Gene Tree for CKLF (if available)
    TreeFam Gene Tree for CKLF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CKLF gene
    CMTM12  CKLF-CMTM12  
    2 SIMAP similar genes for CKLF using alignment to 4 protein entries:     CKLF_HUMAN (see all proteins):
    CKLF-CMTM1    CMTM1

    CKLF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CKLF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906785CNV Loss21882294
    nsv906786CNV Loss21882294
    nsv906787CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    8 diseases for CKLF:    About MalaCards
    ovarian cystadenoma    cystadenoma    acute myocardial infarction    myocardial infarction
    myopathy    hepatitis b    hepatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CKLF:
    Ovarian cystadenoma

    CKLF for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CKLF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 2 14672409 (1), 11415443 (1)
    tumors 0 2 16303766 (1)

    Human Genome Epidemiology (HuGE) Navigator: CKLF (9 documents)

    Export disorders for CKLF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CKLF gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CKLF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. (PubMed id 11415443)1, 2, 3, 9 Han W.... Ma D. (2001)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Chemokine-like factor expression in the idiopathic inflammatory myopathies. (PubMed id 18294340)1, 9 Chowdhury M.H....Yamaguchi S. (2008)
    6. Effects of novel human chemokine-like factor 1 (CKLF1) on bone marrow hematopoietic stem cell/progenitor cell in vitro. (PubMed id 12411060)1, 9 Ke X....Di C. (2002)
    7. [The expression of chemokine-like factor 1 in human a therosclerotic plaques.] (PubMed id 20137403)1, 9 Jiao Y....Zhang X.M. (2009)
    8. Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4. (PubMed id 18069042)1, 9 Wang Y....Ma D. (2008)
    9. Last intron of the chemokine-like factor gene contains a putative promoter for the downstream CKLF super family member 1 gene. (PubMed id 14672709)1, 9 Xu M....Ma D. (2004)
    10. Overexpression of chemokine-like factor 2 promotes the proliferation and survival of C2C12 skeletal muscle cells. (PubMed id 12183067)1, 9 Xia D....Ma D. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51192 HGNC: 13253 AceView: CKLFandCKLFSF1 Ensembl:ENSG00000217555 euGenes: HUgn51192
    ECgene: CKLF H-InvDB: CKLF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CKLF Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/cklf/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CKLF gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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