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Aliases for CKLF Gene

Aliases for CKLF Gene

  • Chemokine-Like Factor 2 3
  • Chemokine-Like Factor 1 2 3
  • CKLF1 3 4
  • C32 3 4
  • Transmembrane Proteolipid 3
  • Chemokine-Like Factor 2 3
  • Chemokine-Like Factor 3 3
  • Chemokine-Like Factor 4 3
  • HSPC224 3
  • CKLF2 3
  • CKLF3 3
  • CKLF4 3
  • UCK-1 3

External Ids for CKLF Gene

Previous HGNC Symbols for CKLF Gene

  • CKLF1

Previous GeneCards Identifiers for CKLF Gene

  • GC16P066964
  • GC16P066321
  • GC16P066362
  • GC16P065143
  • GC16P066586
  • GC16P052462

Summaries for CKLF Gene

Entrez Gene Summary for CKLF Gene

  • The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]

GeneCards Summary for CKLF Gene

CKLF (Chemokine-Like Factor) is a Protein Coding gene. Diseases associated with CKLF include ovarian cystadenoma. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CMTM1.

UniProtKB/Swiss-Prot for CKLF Gene

  • May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.

  • Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Gene Wiki entry for CKLF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKLF Gene

Genomics for CKLF Gene

Regulatory Elements for CKLF Gene

Transcription factor binding sites by QIAGEN in the CKLF gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CKLF Gene

Start:
66,552,563 bp from pter
End:
66,566,287 bp from pter
Size:
13,725 bases
Orientation:
Plus strand

Genomic View for CKLF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKLF Gene

Proteins for CKLF Gene

  • Protein details for CKLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBR5-CKLF_HUMAN
    Recommended name:
    Chemokine-like factor
    Protein Accession:
    Q9UBR5
    Secondary Accessions:
    • C9JE38
    • Q9UHM7
    • Q9UHN8
    • Q9UI41

    Protein attributes for CKLF Gene

    Size:
    152 amino acids
    Molecular mass:
    17170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CKLF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKLF Gene

Proteomics data for CKLF Gene at MOPED

Post-translational modifications for CKLF Gene

  • Ubiquitination at Lys131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CKLF Gene

Domains for CKLF Gene

Protein Domains for CKLF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CKLF Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBR5

UniProtKB/Swiss-Prot:

CKLF_HUMAN :
  • Q9UBR5
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CKLF: view

No data available for Gene Families for CKLF Gene

Function for CKLF Gene

Molecular function for CKLF Gene

UniProtKB/Swiss-Prot Function: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
UniProtKB/Swiss-Prot Function: Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Gene Ontology (GO) - Molecular Function for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Phenotypes for CKLF Gene

GenomeRNAi human phenotypes for CKLF:
genes like me logo Genes that share phenotypes with CKLF: view

Animal Model Products

CRISPR Products

miRNA for CKLF Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKLF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CKLF Gene

Localization for CKLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKLF Gene

Isoform 1: Secreted.
Isoform 2: Membrane; Multi-pass membrane protein.
Isoform 4: Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKLF Gene COMPARTMENTS Subcellular localization image for CKLF gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 11415443
GO:0005615 extracellular space IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Pathways for CKLF Gene

SuperPathways for CKLF Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CKLF Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264001%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000262160%0d%0a
Selected Interacting proteins: ENSP00000264001 for CKLF Gene via STRING

Gene Ontology (GO) - Biological Process for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IDA 11415443
GO:0030593 neutrophil chemotaxis IDA 11415443
GO:0030595 leukocyte chemotaxis --
GO:0032940 secretion by cell IDA 11415443
GO:0048246 macrophage chemotaxis IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

No data available for Pathways by source for CKLF Gene

Compounds for CKLF Gene

(1) Novoseek inferred chemical compound relationships for CKLF Gene

Compound -log(P) Hits PubMed IDs
tarc 77.4 2
genes like me logo Genes that share compounds with CKLF: view

Transcripts for CKLF Gene

Unigene Clusters for CKLF Gene

Chemokine-like factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKLF

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKLF Gene

No ASD Table

Relevant External Links for CKLF Gene

GeneLoc Exon Structure for
CKLF
ECgene alternative splicing isoforms for
CKLF

Expression for CKLF Gene

mRNA expression in normal human tissues for CKLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKLF Gene

This gene is overexpressed in Whole Blood (15.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKLF Gene

SOURCE GeneReport for Unigene cluster for CKLF Gene Hs.15159

mRNA Expression by UniProt/SwissProt for CKLF Gene

Q9UBR5-CKLF_HUMAN
Tissue specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.
genes like me logo Genes that share expressions with CKLF: view

In Situ Assay Products

Orthologs for CKLF Gene

This gene was present in the common ancestor of mammals.

Orthologs for CKLF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKLF 35
  • 99.12 (n)
  • 98.03 (a)
CMTM1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CKLF 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKLF 35
  • 83.78 (n)
  • 76.35 (a)
CKLF 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cklf 35
  • 74.38 (n)
  • 59.86 (a)
Cklf 16
Cklf 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cklf 35
  • 72.89 (n)
  • 60 (a)
Species with no ortholog for CKLF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKLF Gene

ENSEMBL:
Gene Tree for CKLF (if available)
TreeFam:
Gene Tree for CKLF (if available)

Paralogs for CKLF Gene

Paralogs for CKLF Gene

Selected SIMAP similar genes for CKLF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CKLF: view

Variants for CKLF Gene

Structural Variations from Database of Genomic Variants (DGV) for CKLF Gene

Variant ID Type Subtype PubMed ID
nsv906785 CNV Loss 21882294
nsv906786 CNV Loss 21882294
nsv906787 CNV Gain 21882294

Relevant External Links for CKLF Gene

HapMap Linkage Disequilibrium report
CKLF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CKLF Gene

Disorders for CKLF Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CKLF Gene including...

Search for CKLF Gene in MalaCards »

(1) University of Copenhagen DISEASES for CKLF Gene

(2) Novoseek inferred disease relationships for CKLF Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 2
tumors 0 1

Relevant External Links for CKLF

Human Genome Epidemiology (HuGE) Navigator
CKLF
genes like me logo Genes that share disorders with CKLF: view

No data available for UniProtKB/Swiss-Prot for CKLF Gene

Publications for CKLF Gene

  1. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. (PMID: 11415443) Han W. … Ma D. (Biochem. J. 2001) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. [The expression of chemokine-like factor 1 in human atherosclerotic plaques]. (PMID: 20137403) Jiao Y. … Zhang X.M. (Zhonghua Wai Ke Za Zhi 2009) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CKLF Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CKLF
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CKLF
  • Block miRNA regulation of CKLF using miScript Target Protectors

Sources for CKLF Gene

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