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Aliases for CKLF Gene

Aliases for CKLF Gene

  • Chemokine Like Factor 2 3 5
  • Chemokine-Like Factor 1 2 3
  • CKLF1 3 4
  • C32 3 4
  • Transmembrane Proteolipid 3
  • Chemokine-Like Factor 2 3
  • Chemokine-Like Factor 3 3
  • Chemokine-Like Factor 4 3
  • Chemokine-Like Factor 3
  • HSPC224 3
  • CKLF2 3
  • CKLF3 3
  • CKLF4 3
  • UCK-1 3

External Ids for CKLF Gene

Previous HGNC Symbols for CKLF Gene

  • CKLF1

Previous GeneCards Identifiers for CKLF Gene

  • GC16P066964
  • GC16P066321
  • GC16P066362
  • GC16P065143
  • GC16P066586
  • GC16P052462

Summaries for CKLF Gene

Entrez Gene Summary for CKLF Gene

  • The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]

GeneCards Summary for CKLF Gene

CKLF (Chemokine Like Factor) is a Protein Coding gene. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CKLF-CMTM1.

UniProtKB/Swiss-Prot for CKLF Gene

  • May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.

  • Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Gene Wiki entry for CKLF Gene

Additional gene information for CKLF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKLF Gene

Genomics for CKLF Gene

Regulatory Elements for CKLF Gene

Enhancers for CKLF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H066502 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -49.8 -49799 1.2 ELF3 SAP130 ZNF384 CEBPG RAD21 RARA YY1 ZNF366 ATF7 THAP11 TK2 E2F4 CKLF-CMTM1 CKLF ENSG00000260465 CES3 ENSG00000260755 GC16P066491
GH16H066510 1.5 Ensembl ENCODE dbSUPER 12.2 -40.4 -40396 3.8 PKNOX1 FOXA2 ARID4B SIN3A TCF12 ELK1 FOS ATF7 SP5 REST BEAN1 TK2 BEAN1-AS1 CKLF CKLF-CMTM1 CMTM2 CES4A GC16M066512 ENSG00000260851
GH16H066507 1.3 Ensembl ENCODE dbSUPER 11.9 -44.0 -44032 1.5 TBP PKNOX1 JUN MAX RAD21 BATF RFX5 GATA3 SMC3 RCOR1 BEAN1 CKLF TK2 CKLF-CMTM1 ENSG00000260755 GC16P066491
GH16H066585 0.9 FANTOM5 Ensembl 13.8 +34.4 34409 2.9 ZNF316 POLR2A EMSY MAFK BEAN1 TK2 CKLF LINC00920 ENSG00000260650 CMTM3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CKLF on UCSC Golden Path with GeneCards custom track

Promoters for CKLF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the CKLF gene promoter:

Genomic Locations for CKLF Gene

Genomic Locations for CKLF Gene
13,725 bases
Plus strand

Genomic View for CKLF Gene

Genes around CKLF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKLF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKLF Gene

Proteins for CKLF Gene

  • Protein details for CKLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chemokine-like factor
    Protein Accession:
    Secondary Accessions:
    • C9JE38
    • Q9UHM7
    • Q9UHN8
    • Q9UI41

    Protein attributes for CKLF Gene

    152 amino acids
    Molecular mass:
    17170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CKLF Gene


neXtProt entry for CKLF Gene

Post-translational modifications for CKLF Gene

  • Ubiquitination at Lys7 and posLast=131131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CKLF Gene

Domains & Families for CKLF Gene

Gene Families for CKLF Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CKLF Gene


Suggested Antigen Peptide Sequences for CKLF Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chemokine-like factor family.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CKLF: view

Function for CKLF Gene

Molecular function for CKLF Gene

UniProtKB/Swiss-Prot Function:
May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
UniProtKB/Swiss-Prot Function:
Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Gene Ontology (GO) - Molecular Function for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Phenotypes for CKLF Gene

genes like me logo Genes that share phenotypes with CKLF: view

miRNA for CKLF Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CKLF Gene

Localization for CKLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKLF Gene

Isoform 1: Secreted.
Isoform 2: Membrane; Multi-pass membrane protein.
Isoform 4: Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKLF gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 11415443
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IDA,IEA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Pathways & Interactions for CKLF Gene

No Data Available

Interacting Proteins for CKLF Gene

Gene Ontology (GO) - Biological Process for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0008283 cell proliferation IDA 11415443
GO:0030593 neutrophil chemotaxis IDA 11415443
GO:0030595 leukocyte chemotaxis IEA --
GO:0032940 secretion by cell IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

No data available for Pathways by source and SIGNOR curated interactions for CKLF Gene

Drugs & Compounds for CKLF Gene

(1) Additional Compounds for CKLF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CKLF: view

Transcripts for CKLF Gene

Unigene Clusters for CKLF Gene

Chemokine-like factor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKLF Gene

No ASD Table

Relevant External Links for CKLF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CKLF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CKLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKLF Gene

This gene is overexpressed in Whole Blood (x15.0).

Protein differential expression in normal tissues from HIPED for CKLF Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CKLF Gene

Protein tissue co-expression partners for CKLF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CKLF Gene:


SOURCE GeneReport for Unigene cluster for CKLF Gene:


mRNA Expression by UniProt/SwissProt for CKLF Gene:

Tissue specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.

Evidence on tissue expression from TISSUES for CKLF Gene

  • Blood(4.5)
genes like me logo Genes that share expression patterns with CKLF: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CKLF Gene

Orthologs for CKLF Gene

This gene was present in the common ancestor of mammals.

Orthologs for CKLF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CKLF 33
  • 99.12 (n)
CMTM1 34
  • 98 (a)
(Canis familiaris)
Mammalia CKLF 33 34
  • 83.78 (n)
(Mus musculus)
Mammalia Cklf 33 16 34
  • 74.38 (n)
(Bos Taurus)
Mammalia CKLF 34
  • 73 (a)
(Rattus norvegicus)
Mammalia Cklf 33
  • 72.89 (n)
Species where no ortholog for CKLF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKLF Gene

Gene Tree for CKLF (if available)
Gene Tree for CKLF (if available)

Paralogs for CKLF Gene

Paralogs for CKLF Gene

(2) SIMAP similar genes for CKLF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CKLF: view

Variants for CKLF Gene

Sequence variations from dbSNP and Humsavar for CKLF Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000375684 -- 66,560,839(+) CACAC(A/T)TTCTC intron-variant
rs1000388020 -- 66,552,895(+) AACCT(C/T)GCTTT intron-variant
rs1000665043 -- 66,562,398(+) AGACT(A/G)CTCTG intron-variant
rs1000685295 -- 66,560,529(+) ATATG(A/G)AGATA intron-variant
rs1000778372 -- 66,554,411(+) ATTGA(G/T)GCAGA intron-variant

Variation tolerance for CKLF Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKLF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CKLF Gene

Disorders for CKLF Gene

Relevant External Links for CKLF

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CKLF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKLF Gene

Publications for CKLF Gene

  1. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. (PMID: 11415443) Han W … Ma D (The Biochemical journal 2001) 2 3 4 22 60
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 60
  3. [The expression of chemokine-like factor 1 in human atherosclerotic plaques]. (PMID: 20137403) Jiao Y … Zhang XM (Zhonghua wai ke za zhi [Chinese journal of surgery] 2009) 3 22 60
  4. Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4. (PMID: 18069042) Wang Y … Ma D (The international journal of biochemistry & cell biology 2008) 3 22 60
  5. Chemokine-like factor expression in the idiopathic inflammatory myopathies. (PMID: 18294340) Chowdhury MH … Yamaguchi S (Acta neurologica Scandinavica 2008) 3 22 60

Products for CKLF Gene

Sources for CKLF Gene

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