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Aliases for CKLF Gene

Aliases for CKLF Gene

  • Chemokine Like Factor 2 3 5
  • Chemokine-Like Factor 1 2 3
  • CKLF1 3 4
  • C32 3 4
  • Transmembrane Proteolipid 3
  • Chemokine-Like Factor 2 3
  • Chemokine-Like Factor 3 3
  • Chemokine-Like Factor 4 3
  • Chemokine-Like Factor 3
  • HSPC224 3
  • CKLF2 3
  • CKLF3 3
  • CKLF4 3
  • UCK-1 3

External Ids for CKLF Gene

Previous HGNC Symbols for CKLF Gene

  • CKLF1

Previous GeneCards Identifiers for CKLF Gene

  • GC16P066964
  • GC16P066321
  • GC16P066362
  • GC16P065143
  • GC16P066586
  • GC16P052462

Summaries for CKLF Gene

Entrez Gene Summary for CKLF Gene

  • The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]

GeneCards Summary for CKLF Gene

CKLF (Chemokine Like Factor) is a Protein Coding gene. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CKLF-CMTM1.

UniProtKB/Swiss-Prot for CKLF Gene

  • May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.

  • Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Gene Wiki entry for CKLF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKLF Gene

Genomics for CKLF Gene

Regulatory Elements for CKLF Gene

Enhancers for CKLF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F066519 1.1 FANTOM5 ENCODE 29 -29.2 -29165 8.1 PKNOX1 ATF1 WRNIP1 SIN3A ZNF766 GATA2 ZNF143 ZNF548 JUNB TBX21 TK2 CKLF BEAN1 CKLF-CMTM1 E2F4 ENSG00000260465 ZDHHC1 LINC00920 CMTM1 ENSG00000260851
GH16F066585 1.3 FANTOM5 Ensembl 13.8 +34.3 34339 3.0 ATF1 PKNOX1 INSM2 FEZF1 ZNF335 GLIS2 ZNF766 ZNF366 SCRT2 CREM BEAN1 TK2 CKLF LINC00920 ENSG00000260650 CMTM3
GH16F066510 1 Ensembl ENCODE 12.2 -40.4 -40396 3.8 PKNOX1 ARID4B SIN3A ZNF121 ELK1 FOS SP5 REST PPARG SMARCB1 BEAN1 TK2 BEAN1-AS1 CKLF CKLF-CMTM1 CMTM2 CES4A GC16M066512 ENSG00000260851
GH16F066515 1 ENCODE 12 -35.4 -35412 4.0 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 SP3 BEAN1 TK2 ZDHHC1 CKLF CKLF-CMTM1 E2F4 CMTM2 PLEKHG4 KIAA0895L ENSG00000260851
GH16F066507 1.2 Ensembl ENCODE 11.9 -44.0 -44032 1.5 TBP PKNOX1 JUN MAX RAD21 RFX5 SCRT2 SMC3 RCOR1 FOS BEAN1 CKLF CKLF-CMTM1 TK2 ENSG00000260755 GC16P066491
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CKLF on UCSC Golden Path with GeneCards custom track

Promoters for CKLF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001802231 437 2001 HDGF ARNT CREB3L1 MLX ZFP64 ARID4B DMAP1 ZNF2 YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the CKLF gene promoter:

Genomic Location for CKLF Gene

Chromosome:
16
Start:
66,552,563 bp from pter
End:
66,566,287 bp from pter
Size:
13,725 bases
Orientation:
Plus strand

Genomic View for CKLF Gene

Genes around CKLF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKLF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKLF Gene

Proteins for CKLF Gene

  • Protein details for CKLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBR5-CKLF_HUMAN
    Recommended name:
    Chemokine-like factor
    Protein Accession:
    Q9UBR5
    Secondary Accessions:
    • C9JE38
    • Q9UHM7
    • Q9UHN8
    • Q9UI41

    Protein attributes for CKLF Gene

    Size:
    152 amino acids
    Molecular mass:
    17170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CKLF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKLF Gene

Post-translational modifications for CKLF Gene

  • Ubiquitination at Lys 7 and Lys 131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CKLF Gene

Domains & Families for CKLF Gene

Protein Domains for CKLF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CKLF Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBR5

UniProtKB/Swiss-Prot:

CKLF_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CKLF: view

No data available for Gene Families for CKLF Gene

Function for CKLF Gene

Molecular function for CKLF Gene

UniProtKB/Swiss-Prot Function:
May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
UniProtKB/Swiss-Prot Function:
Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Gene Ontology (GO) - Molecular Function for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Phenotypes for CKLF Gene

genes like me logo Genes that share phenotypes with CKLF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CKLF

miRNA for CKLF Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CKLF Gene

Localization for CKLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKLF Gene

Isoform 1: Secreted.
Isoform 2: Membrane; Multi-pass membrane protein.
Isoform 4: Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKLF Gene COMPARTMENTS Subcellular localization image for CKLF gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 11415443
GO:0005615 extracellular space IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA,IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Pathways & Interactions for CKLF Gene

SuperPathways for CKLF Gene

No Data Available

Interacting Proteins for CKLF Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264001%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000262160%0d%0a
Selected Interacting proteins: ENSP00000264001 Q9UBR5-CKLF_HUMAN for CKLF Gene via STRING IID

Gene Ontology (GO) - Biological Process for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0008283 cell proliferation IDA 11415443
GO:0030593 neutrophil chemotaxis IDA 11415443
GO:0030595 leukocyte chemotaxis IEA --
GO:0032940 secretion by cell IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

No data available for Pathways by source and SIGNOR curated interactions for CKLF Gene

Drugs & Compounds for CKLF Gene

(1) Additional Compounds for CKLF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CKLF: view

Transcripts for CKLF Gene

Unigene Clusters for CKLF Gene

Chemokine-like factor:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKLF Gene

No ASD Table

Relevant External Links for CKLF Gene

GeneLoc Exon Structure for
CKLF
ECgene alternative splicing isoforms for
CKLF

Expression for CKLF Gene

mRNA expression in normal human tissues for CKLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKLF Gene

This gene is overexpressed in Whole Blood (x15.0).

Protein differential expression in normal tissues from HIPED for CKLF Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CKLF Gene



Protein tissue co-expression partners for CKLF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CKLF Gene:

CKLF

SOURCE GeneReport for Unigene cluster for CKLF Gene:

Hs.15159

mRNA Expression by UniProt/SwissProt for CKLF Gene:

Q9UBR5-CKLF_HUMAN
Tissue specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.
genes like me logo Genes that share expression patterns with CKLF: view

Primer Products

Orthologs for CKLF Gene

This gene was present in the common ancestor of mammals.

Orthologs for CKLF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKLF 34
  • 99.12 (n)
CMTM1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKLF 34 35
  • 83.78 (n)
mouse
(Mus musculus)
Mammalia Cklf 34 16 35
  • 74.38 (n)
cow
(Bos Taurus)
Mammalia CKLF 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cklf 34
  • 72.89 (n)
Species where no ortholog for CKLF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKLF Gene

ENSEMBL:
Gene Tree for CKLF (if available)
TreeFam:
Gene Tree for CKLF (if available)

Paralogs for CKLF Gene

Paralogs for CKLF Gene

(2) SIMAP similar genes for CKLF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CKLF: view

Variants for CKLF Gene

Sequence variations from dbSNP and Humsavar for CKLF Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1108281 -- 66,552,286(-) GGGCT(C/G)TAGAA upstream-variant-2KB
rs111468662 -- 66,557,270(+) TCAAG(C/G)GATTC intron-variant
rs111500419 -- 66,560,157(+) AAAGT(C/G)CTTTT intron-variant
rs111551184 -- 66,558,447(+) GGTAA(C/T)CTCTG intron-variant
rs111641127 -- 66,555,520(+) AACTG(A/G)AAGGA intron-variant

Variation tolerance for CKLF Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKLF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKLF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CKLF Gene

Disorders for CKLF Gene

Relevant External Links for CKLF

Human Genome Epidemiology (HuGE) Navigator
CKLF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKLF

No disorders were found for CKLF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKLF Gene

Publications for CKLF Gene

  1. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. (PMID: 11415443) Han W. … Ma D. (Biochem. J. 2001) 2 3 4 22 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. [The expression of chemokine-like factor 1 in human atherosclerotic plaques]. (PMID: 20137403) Jiao Y. … Zhang X.M. (Zhonghua Wai Ke Za Zhi 2009) 3 22 64
  4. Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4. (PMID: 18069042) Wang Y. … Ma D. (Int. J. Biochem. Cell Biol. 2008) 3 22 64
  5. Chemokine-like factor expression in the idiopathic inflammatory myopathies. (PMID: 18294340) Chowdhury M.H. … Yamaguchi S. (Acta Neurol. Scand. 2008) 3 22 64

Products for CKLF Gene

Sources for CKLF Gene

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