Aliases for CKLF Gene
External Ids for CKLF Gene
Previous HGNC Symbols for CKLF Gene
Previous GeneCards Identifiers for CKLF Gene
The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]
GeneCards Summary for CKLF Gene
CKLF (Chemokine-Like Factor) is a Protein Coding gene. Diseases associated with CKLF include ovarian cystadenoma. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CMTM1.
UniProtKB/Swiss-Prot for CKLF Gene
May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).