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Aliases for CKB Gene

Aliases for CKB Gene

  • Creatine Kinase B 2 3
  • Creatine Kinase, Brain 2 3 5
  • Creatine Kinase Brain-Type 2 3
  • Creatine Kinase B Chain 3 4
  • EC 2.7.3.2 4 63
  • CKBB 3 4
  • B-CK 3 4
  • Epididymis Secretory Protein Li 29 3
  • Epididymis Luminal Protein 211 3
  • Creatine Kinase Brain 3
  • Creatine Kinase-B 3
  • HEL-S-29 3
  • EC 2.7.3 63
  • HEL-211 3
  • BCK 3

External Ids for CKB Gene

Previous HGNC Symbols for CKB Gene

  • CKBB

Previous GeneCards Identifiers for CKB Gene

  • GC14M101377
  • GC14M097801
  • GC14M101976
  • GC14M103055
  • GC14M103986

Summaries for CKB Gene

Entrez Gene Summary for CKB Gene

  • The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKB Gene

CKB (Creatine Kinase B) is a Protein Coding gene. Diseases associated with CKB include prostate rhabdomyosarcoma and dressler's syndrome. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is CKMT1B.

UniProtKB/Swiss-Prot for CKB Gene

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKB Gene

Genomics for CKB Gene

Regulatory Elements for CKB Gene

Promoters for CKB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CKB on UCSC Golden Path with GeneCards custom track

Genomic Location for CKB Gene

Chromosome:
14
Start:
103,519,658 bp from pter
End:
103,523,111 bp from pter
Size:
3,454 bases
Orientation:
Minus strand

Genomic View for CKB Gene

Genes around CKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKB Gene

Proteins for CKB Gene

  • Protein details for CKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12277-KCRB_HUMAN
    Recommended name:
    Creatine kinase B-type
    Protein Accession:
    P12277
    Secondary Accessions:
    • A8K236
    • B2R5R4
    • Q2LE07
    • Q6FG40
    • Q9UC66

    Protein attributes for CKB Gene

    Size:
    381 amino acids
    Molecular mass:
    42644 Da
    Quaternary structure:
    • Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

    Three dimensional structures from OCA and Proteopedia for CKB Gene

neXtProt entry for CKB Gene

Proteomics data for CKB Gene at MOPED

Post-translational modifications for CKB Gene

  • Ubiquitination at Lys 11, Lys 223, Lys 242, Lys 265, Lys 298, Lys 304, Lys 307, and Lys 313
  • Modification sites at PhosphoSitePlus

Other Protein References for CKB Gene

Domains & Families for CKB Gene

Suggested Antigen Peptide Sequences for CKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12277

UniProtKB/Swiss-Prot:

KCRB_HUMAN :
  • Contains 1 phosphagen kinase C-terminal domain.
  • Belongs to the ATP:guanido phosphotransferase family.
Domain:
  • Contains 1 phosphagen kinase C-terminal domain.
  • Contains 1 phosphagen kinase N-terminal domain.
Family:
  • Belongs to the ATP:guanido phosphotransferase family.
genes like me logo Genes that share domains with CKB: view

No data available for Gene Families for CKB Gene

Function for CKB Gene

Molecular function for CKB Gene

GENATLAS Biochemistry:
creatine kinase,brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + creatine = ADP + phosphocreatine.
UniProtKB/Swiss-Prot Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Enzyme Numbers (IUBMB) for CKB Gene

Gene Ontology (GO) - Molecular Function for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CKB: view
genes like me logo Genes that share phenotypes with CKB: view

Animal Models for CKB Gene

MGI Knock Outs for CKB:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKB Gene

Localization for CKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKB Gene COMPARTMENTS Subcellular localization image for CKB gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 4
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with CKB: view

Pathways & Interactions for CKB Gene

genes like me logo Genes that share pathways with CKB: view

Gene Ontology (GO) - Biological Process for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030644 cellular chloride ion homeostasis IEA --
genes like me logo Genes that share ontologies with CKB: view

No data available for SIGNOR curated interactions for CKB Gene

Drugs & Compounds for CKB Gene

(17) Drugs for CKB Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Creatine Approved Nutra Target, ligand 110
Adenosine triphosphate Approved Nutra 0
Phosphocreatine Pharma 6

(14) Additional Compounds for CKB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CKB: view

Transcripts for CKB Gene

Unigene Clusters for CKB Gene

Creatine kinase, brain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKB Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for CKB Gene

GeneLoc Exon Structure for
CKB
ECgene alternative splicing isoforms for
CKB

Expression for CKB Gene

mRNA expression in normal human tissues for CKB Gene

Protein differential expression in normal tissues from HIPED for CKB Gene

This gene is overexpressed in Retina (13.0), Brain (6.7), and Cardia (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKB Gene



SOURCE GeneReport for Unigene cluster for CKB Gene Hs.173724

genes like me logo Genes that share expression patterns with CKB: view

Protein tissue co-expression partners for CKB Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CKB Gene

Orthologs for CKB Gene

This gene was present in the common ancestor of animals.

Orthologs for CKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKB 36
  • 100 (a)
OneToOne
CKB 35
  • 99.74 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CKB 35
  • 93.18 (n)
  • 97.11 (a)
CKB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
CKB 36
  • 98 (a)
OneToMany
CKB 35
  • 94.23 (n)
  • 97.64 (a)
mouse
(Mus musculus)
Mammalia Ckb 16
Ckb 36
  • 97 (a)
OneToOne
Ckb 35
  • 90.46 (n)
  • 96.59 (a)
oppossum
(Monodelphis domestica)
Mammalia CKB 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ckb 35
  • 91.34 (n)
  • 96.59 (a)
chicken
(Gallus gallus)
Aves CKB 35
  • 79.44 (n)
  • 90.55 (a)
CKB 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ckb 35
  • 74.1 (n)
  • 85.3 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1737 35
zebrafish
(Danio rerio)
Actinopterygii ckba 36
  • 84 (a)
OneToMany
ckbb 36
  • 86 (a)
OneToMany
-- 35
ckbb 35
  • 77.78 (n)
  • 85.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Argk 37
  • 38 (a)
CG4546 37
  • 36 (a)
CG5144 37
  • 38 (a)
Argk 36
  • 28 (a)
ManyToMany
CG30274 36
  • 19 (a)
ManyToMany
CG4546 36
  • 29 (a)
ManyToMany
CG5144 36
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F32B5.1 37
  • 40 (a)
F44G3.2 37
  • 39 (a)
W10C8.5 37
  • 39 (a)
ZC434.8 37
  • 40 (a)
F11G11.13 36
  • 33 (a)
ManyToMany
F32B5.1 36
  • 33 (a)
ManyToMany
F44G3.2 36
  • 38 (a)
ManyToMany
F46H5.3 36
  • 37 (a)
ManyToMany
W10C8.5 36
  • 36 (a)
ManyToMany
ZC434.8 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2638 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
ManyToMany
CSA.6164 36
  • 69 (a)
ManyToMany
Species with no ortholog for CKB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKB Gene

ENSEMBL:
Gene Tree for CKB (if available)
TreeFam:
Gene Tree for CKB (if available)

Paralogs for CKB Gene

Paralogs for CKB Gene

(4) SIMAP similar genes for CKB Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CKB Gene

genes like me logo Genes that share paralogs with CKB: view

Variants for CKB Gene

Sequence variations from dbSNP and Humsavar for CKB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs36002620 - 103,521,386(-) GCTCA(A/G)GAGCA reference, missense
rs35156510 - 103,520,163(-) GTTCT(C/T)GGAGG reference, missense
rs12505 - 103,519,932(-) AGCTG(C/T)TCATC reference, missense
rs13558 -- 103,520,290(-) AGTCT(A/G)AGGAC reference, missense
rs1064582 -- 103,519,749(-) TAGAG(A/G)CTTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CKB Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
dgv1992n71 CNV Loss 21882294
nsv902300 CNV Loss 21882294
dgv1993n71 CNV Loss 21882294
dgv1994n71 CNV Loss 21882294
nsv827068 CNV Loss 20364138
esv29714 CNV Loss 19812545

Variation tolerance for CKB Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKB Gene

HapMap Linkage Disequilibrium report
CKB
Human Gene Mutation Database (HGMD)
CKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKB Gene

Disorders for CKB Gene

MalaCards: The human disease database

(6) MalaCards diseases for CKB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate rhabdomyosarcoma
  • rhabdomyosarcoma of the prostate
dressler's syndrome
  • dressler syndrome
prostate sarcoma
  • sarcoma of the prostate
small cell cancer of the lung, somatic
  • lung small cell carcinoma
acute myocardial infarction
- elite association - COSMIC cancer census association via MalaCards
Search CKB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CKB

Genetic Association Database (GAD)
CKB
Human Genome Epidemiology (HuGE) Navigator
CKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKB
genes like me logo Genes that share disorders with CKB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKB Gene

Publications for CKB Gene

  1. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. (PMID: 17148442) Debrincat M.A. … Hilton D.J. (J. Biol. Chem. 2007) 3 23 25 26
  2. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PMID: 16384981) Haines J.L. … Pericak-Vance M.A. (Invest. Ophthalmol. Vis. Sci. 2006) 3 23 48 67
  3. Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase. (PMID: 17036164) BA1rklen T.S. … Wallimann T. (Mol. Cell. Biochem. 2007) 3 25 26
  4. Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter. (PMID: 20520825) Steen C. … De Keyser J. (PLoS ONE 2010) 3 23
  5. Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain-type creatine kinase as novel autoantigens. (PMID: 18552983) Okunuki Y. … Takeuchi M. (Mol. Vis. 2008) 3 23

Products for CKB Gene

Sources for CKB Gene

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