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CKB Gene

protein-coding   GIFtS: 70
GCID: GC14M103986

Creatine Kinase, Brain


(Previous symbol: CKBB)
  See CKB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Creatine Kinase, Brain1 2     HEL-S-292
CKBB1 2 3 5     Creatine Kinase B-Type2
Creatine Kinase B Chain2 3     Creatine Kinase-B2
B-CK2 3     Epididymis Luminal Protein 2112
EC 2.7.3.23 8     Epididymis Secretory Protein Li 292
BCK2 5     EC 2.7.38
HEL-2112     

External Ids:    HGNC: 19911   Entrez Gene: 11522   Ensembl: ENSG000001661657   OMIM: 1232805   UniProtKB: P122773   

Export aliases for CKB gene to outside databases

Previous GC identifers: GC14M101377 GC14M097801 GC14M101976 GC14M103055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CKB Gene:
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein
reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It
acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in
heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this
gene has been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKB Gene:
CKB (creatine kinase, brain) is a protein-coding gene. Diseases associated with CKB include prostate rhabdomyosarcoma, and brain ischemia. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKM.

UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKB gene promoter:
         Max1   USF1   AP-2alpha isoform 3   USF-1:USF-2   AP-2alpha isoform 2   SRY   USF-1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKB promoter sequence
   Search Chromatin IP Primers for CKB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.32

CKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M103986:  view genomic region     (about GC identifiers)

Start:
103,985,996 bp from pter      End:
103,989,448 bp from pter
Size:
3,453 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277 (See protein sequence)
Recommended Name: Creatine kinase B-type  
Size: 381 amino acids; 42644 Da
Subunit: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and
myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain
3 PDB 3D structures from and Proteopedia for CKB:
3B6R (3D)        3DRB (3D)        3DRE (3D)    
Secondary accessions: A8K236 B2R5R4 Q2LE07 Q6FG40 Q9UC66

Explore the universe of human proteins at neXtProt for CKB: NX_P12277

Explore proteomics data for CKB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys223, Lys242, Lys265, Lys298, Lys304, Lys307, Lys313
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CKB (P12277) (see all 28)
     CPSNLGT  NEEDHLR  GGDDLDP  SEVELVQ 


    See CKB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001814.2  
    ENSEMBL proteins: 
     ENSP00000299198   ENSP00000451680   ENSP00000450676   ENSP00000451426   ENSP00000451686  
     ENSP00000451904   ENSP00000451611  
    Reactome Protein details: P12277

    CKB Human Recombinant Protein Products:

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    Novus Biologicals CKB Proteins
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    Sino Biological Recombinant Protein for CKB
    Sino Biological Cell Lysate for CKB
    ProSpec Recombinant Protein for CKB
    Cloud-Clone Corp. Proteins for CKB

     
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    antibodies-online proteins for CKB (39 products) 

     
    antibodies-online peptides for CKB

    CKB Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CKB
    antibodies-online antibodies for CKB (116 products) 

    CKB Assay Products:

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    Cloud-Clone Corp. ELISAs for CKB
    Cloud-Clone Corp. CLIAs for CKB
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    antibodies-online kits for CKB (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P12277

    ProtoNet protein and cluster: P12277

    1 Blocks protein domain: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    Find genes that share domains with CKB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRB_HUMAN, P12277
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
    phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
    fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Genatlas biochemistry entry for CKB:
    creatine kinase,brain

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with CKB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CKB:
     Decreased 12E8 tau but not tot 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ckb):
     behavior/neurological  growth/size/body  nervous system 

    Find genes that share phenotypes with CKB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ckbtm1Bew for CKB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKB

    miRNA
    Products:
        
    miRTarBase miRNAs that target CKB:
    hsa-let-7b-5p (MIRT052190), hsa-mir-196b-5p (MIRT042674), hsa-mir-92a-3p (MIRT049124), hsa-mir-320a (MIRT044642), hsa-mir-346 (MIRT042718), hsa-mir-324-5p (MIRT043074), hsa-mir-744-5p (MIRT037448), hsa-mir-935 (MIRT036653), hsa-mir-1260b (MIRT052723)

    Block miRNA regulation of human, mouse, rat CKB using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CKB:
    hsa-miR-3926 hsa-miR-3613-3p hsa-miR-205* hsa-miR-618 hsa-miR-139-5p hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidCKB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CKB
    Predesigned siRNA for gene silencing in human, mouse, rat CKB

    Gene Editing
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    Sino Biological Human cDNA Clone for CKB
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKB
    Addgene plasmids for CKB 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCRB_HUMAN, P12277: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA11487543

    Find genes that share ontologies with CKB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CKB About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Creatine metabolism0.00
    creatine-phosphate biosynthesis0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Arginine and proline metabolism
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups0.00
    4Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Abacavir Pathway, Pharmacokinetics/Pharmacodynamics


    Find genes that share SuperPaths with CKB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CKB
        creatine-phosphate biosynthesis
    Urea cycle and metabolism of amino groups


    1 Reactome Pathway for CKB
        Creatine metabolism

    1 PharmGKB Pathway for CKB
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics

    2 Kegg Pathways  (Kegg details for CKB):
        Arginine and proline metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CKB: 
              Estrogen Receptor Signaling in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CKB (P122771, 2, 3 ENSP000002991984) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, 3, ENSP000002265744MINT-48546 I2D: score=1 STRING: ENSP00000226574
    TAB1Q157502, 3MINT-8260064 I2D: score=2 
    CGBP012333I2D: score=1 
    CGB5P012333I2D: score=1 
    CGB7P012333I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process TAS--
    GO:0007420brain development ----
    GO:0021762substantia nigra development IEP--
    GO:0030644cellular chloride ion homeostasis IEA--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    Find genes that share ontologies with CKB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKB (KCRB)

    4 HMDB Compounds for CKB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    PhosphocreatineCreatine phosphate (see all 15)67-07-2--

    1 DrugBank Compound for CKB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Creatine(alpha-Methylguanido)acetic acid (see all 6)57-00-1targetligand17036164 17148442 16875703 1731757

    Selected Novoseek inferred chemical compound relationships for CKB gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 85.8 294 19337362 (6), 11804344 (4), 9547297 (4), 7781040 (3) (see all 99)
    tamoxifen methiodide 85.1 2 11384866 (1), 9010344 (1)
    phosphocreatine 60.9 9 8923416 (3), 20520825 (2), 1531784 (1), 8940627 (1)
    raloxifene 32.1 2 11384866 (1), 9010344 (1)
    atp 31.5 11 19333390 (2), 17029789 (1), 15892163 (1), 1950416 (1) (see all 7)
    lactate 29.6 18 1541099 (2), 8634377 (2), 7841274 (2), 17934974 (1) (see all 10)
    tamoxifen 26.3 2 11384866 (1), 9010344 (1)
    isocitrate 23.8 2 8567810 (1), 16912971 (1)
    aspartate 21.8 5 7841727 (1), 18552983 (1), 1601350 (1), 8634377 (1) (see all 5)
    percoll 16.5 1 8833742 (1)



    Find genes that share compounds with CKB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CKB gene: 
    NM_001823.4  

    Unigene Cluster for CKB:

    Creatine kinase, brain
    Hs.173724  [show with all ESTs]
    Unigene Representative Sequence: BC040666
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348956(uc001ynf.2) ENST00000554989 ENST00000554282 ENST00000553528
    ENST00000553652 ENST00000553610 ENST00000555039 ENST00000555366 ENST00000557569
    ENST00000554426 ENST00000553878 ENST00000557287 ENST00000555659 ENST00000554705
    ENST00000555770 ENST00000557530 ENST00000553994
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CKB:
    hsa-miR-3926 hsa-miR-3613-3p hsa-miR-205* hsa-miR-618 hsa-miR-139-5p hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidCKB 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for CKB 
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    OriGene qSTAR qPCR primer pairs in human, mouse for CKB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CKB
      QuantiTect SYBR Green Assays in human, mouse, rat CKB
      QuantiFast Probe-based Assays in human, mouse, rat CKB

    Additional mRNA sequence: 

    AK290101.1 AK298198.1 AK312282.1 BC001190.1 BC004914.2 BC008323.1 BC010002.2 BC019259.1 
    BC019281.1 BC040666.2 BC111085.1 CR542268.1 L47647.1 M16364.1 M16451.1 

    Selected DOTS entries (see all 51):

    DT.100688053  DT.100856085  DT.40291664  DT.97795378  DT.100656447  DT.100679969  DT.91799070  DT.100772203 
    DT.40310087  DT.120747593  DT.91670517  DT.95302733  DT.102837438  DT.87017656  DT.95309524  DT.100641046 
    DT.120747483  DT.120747499  DT.91765918  DT.100679979  DT.91982828  DT.95309516  DT.97864534  DT.100846484 

    Selected AceView cDNA sequences (see all 1026):

    BU726169 AU104794 CB155552 BM721647 CR604715 BI254049 BU742288 CB268254 
    NM_001823 CF127987 CB117129 BQ943624 BF725281 CR604286 BM677250 AU104802 
    CR604078 BU932063 BF038095 CR609423 CR617409 BX393597 CR592666 AI984300 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CKB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                          -                 -                 -     -     -           -                                 
    SP2:                                            -                 -     -     -           -     -                           
    SP3:              -           -                 -                                                                           
    SP4:                                                                                      -                                 
    SP5:                          -                 -                                                                           


    ECgene alternative splicing isoforms for CKB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CKB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCCCTGAT
    CKB Expression
    About this image


    CKB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
    CKB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173724
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CKB: 
              Estrogen Receptor Signaling in human mouse rat
              Amino Acid Metabolism I in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CKB gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckb1 , 5 creatine kinase, brain1, 5 90.46(n)1
    96.59(a)1
      12 (61.09 cM)5
    127091  NM_021273.41  NP_067248.11 
     1116693555 
    chicken
    (Gallus gallus)
    Aves CKB1 creatine kinase, brain 79.44(n)
    90.55(a)
      396248  NM_205310.1  NP_990641.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    82(a)
    79(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343267.1(1341512-1341911)
    GL343232.1(117323-137732)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ckb1 creatine kinase, brain 74.1(n)
    85.3(a)
      733543  NM_001044461.1  NP_001037926.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY055849.12   -- 79.33(n)   140744  AY055849.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Argk3 phosphorylation arginine kinase 38(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F32B5.13 phosphotransferase 40(a)
    (best of 4)
      I(2700421-2702083)   --


    ENSEMBL Gene Tree for CKB (if available)
    TreeFam Gene Tree for CKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CKB gene
    CKM2  CKMT1B2  CKMT22  CKMT1A2  
    4 SIMAP similar genes for CKB using alignment to 7 protein entries:     KCRB_HUMAN (see all proteins):
    CKM    CKMT1B    CKMT1A    CKMT2

    Find genes that share paralogs with CKB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CKB
    PGOHUM00000261881


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CKB (see all 143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344715671,2
    C,F,H--103985632(-) TCCAAC/TTGGCT 1 -- ds50018Minor allele frequency- T:0.00NS NA 686
    rs360891681,2
    C,F--103985726(-) TGGCAC/TGTTCC 1 -- ds50017Minor allele frequency- T:0.04NS WA 296
    rs775424271,2
    F--103985771(+) TCAGGC/TCTGGA 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs356832151,2
    C,F--103985795(-) CATGGG/AAGAGA 1 -- ds50017Minor allele frequency- A:0.04NS WA 310
    rs1469548541,2
    --103985812(+) CCTGCA/GCAGCC 1 -- ds50010--------
    rs342447281,2
    C,F--103985819(-) TCTATC/TGGGCT 1 -- ds50016Minor allele frequency- T:0.04NS WA 308
    rs353584071,2
    C,F--103985868(-) CCACTC/GTGTTC 1 -- ds50016Minor allele frequency- G:0.01NS NA 310
    rs753557221,2
    C--103985901(+) TCTCAC/GAGAAG 1 -- ds50010--------
    rs1118670521,2
    C--103986003(+) GACGCT/AGGCAG 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs1129745591,2
    C--103986155(+) CAGGCT/AATAAG 1 -- ut311Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for CKB (103985996 - 103989448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CKB:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1992n71CNV Loss21882294
    nsv832883CNV Loss17160897
    dgv1993n71CNV Loss21882294
    nsv827068CNV Loss20364138
    esv29714CNV Loss19812545
    nsv902300CNV Loss21882294
    dgv1994n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): CKB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CKB
    DNA2.0 Custom Variant and Variant Library Synthesis for CKB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123280    OMIM disorders: --

    3 diseases for CKB:    
    About MalaCards
    prostate rhabdomyosarcoma    brain ischemia    myocardial infarction

    2 diseases from the University of Copenhagen DISEASES database for CKB:
    Myocardial infarction     Prostate rhabdomyosarcoma

    Find genes that share disorders with CKB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CKB gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fetal acidosis 54.7 1 7823262 (1)
    bowel infarction 42.4 1 1935497 (1)
    encephalopathies hypoxic-ischemic 39.2 2 12736385 (1)
    anoxic encephalopathy 37.3 1 8509798 (1)
    acute myocardial infarction 33.3 7 8120516 (3), 1511070 (1), 2096250 (1)
    meningitis bacterial 33.3 1 7841727 (1)
    brain ischemia 29.7 1 8509798 (1)
    asphyxia 28.7 7 10732307 (4), 12736385 (2), 2303153 (1)
    small cell lung cancer 27.1 5 1645850 (1), 1645171 (1), 7657349 (1), 1766488 (1)
    involvement cns 24.6 3 8402452 (3)

    Genetic Association Database (GAD): CKB
    Human Genome Epidemiology (HuGE) Navigator: CKB (20 documents)

    Export disorders for CKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CKB gene, integrated from 10 sources (see all 263):
    (articles sorted by number of sources associating them with CKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. (PubMed id 17148442)1, 7, 9 Debrincat M.A....Hilton D.J. (J. Biol. Chem. 2007)
    2. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PubMed id 16384981)1, 4, 9 Haines J.L....Pericak-Vance M.A. (amp 2006)
    3. Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex. (PubMed id 18977227)1, 2 Bong S.M.... Hwang K.Y. (FEBS Lett. 2008)
    4. Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase. (PubMed id 17036164)1, 7 BA1rklen T.S....Wallimann T. (Mol. Cell. Biochem. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Determination of the catalytic site of creatine kinase by site- directed mutagenesis. (PubMed id 8186255)1, 2 Lin L.... Ma T.S. (Biochim. Biophys. Acta 1994)
    7. Complete nucleotide sequence of the human creatine kinase B gene. (PubMed id 2771648)1, 2 Mariman E.C.M.... Wieringa B. (Nucleic Acids Res. 1989)
    8. Isolation of a functional human gene for brain creatine kinase. (PubMed id 2828370)1, 2 Daouk G.H.... Schimmel P. (J. Biol. Chem. 1988)
    9. Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci. (PubMed id 2883200)1, 2 Kaye F.J.... Sausville E.A. (J. Clin. Invest. 1987)
    10. Structure and expression of the human creatine kinase B gene. (PubMed id 3692484)1, 2 Mariman E.C.M....Wieringa B. (Genomics 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1152 HGNC: 1991 AceView: CKB Ensembl:ENSG00000166165 euGenes: HUgn1152
    ECgene: CKB Kegg: 1152 H-InvDB: CKB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CKB Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ckb/
    Wikipedia http://en.wikipedia.org/wiki/Creatine_kinase
    Wikipedia http://en.wikipedia.org/wiki/CKB_(gene)

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CKB gene:
    Search GeneIP for patents involving CKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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