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Aliases for CKB Gene

Aliases for CKB Gene

  • Creatine Kinase, Brain 2 3
  • CKBB 3 4 6
  • Creatine Kinase B Chain 3 4
  • EC 4 64
  • B-CK 3 4
  • BCK 3 6
  • Epididymis Secretory Protein Li 29 3
  • Epididymis Luminal Protein 211 3
  • Creatine Kinase B-Type 3
  • Creatine Kinase-B 3
  • HEL-S-29 3
  • EC 2.7.3 64
  • HEL-211 3

External Ids for CKB Gene

Previous Symbols for CKB Gene

  • CKBB

Summaries for CKB Gene

Entrez Gene Summary for CKB Gene

  • The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKB Gene

CKB (Creatine Kinase, Brain) is a Protein Coding gene. Diseases associated with CKB include prostate rhabdomyosarcoma and brain ischemia. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKMT1B.

UniProtKB/Swiss-Prot for CKB Gene

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKB Gene

Genomics for CKB Gene

Genomic Location for CKB Gene

103,519,658 bp from pter
103,523,111 bp from pter
3,454 bases
Minus strand

Genomic View for CKB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKB Gene

Proteins for CKB Gene

  • Protein details for CKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Creatine kinase B-type
    Protein Accession:
    Secondary Accessions:
    • A8K236
    • B2R5R4
    • Q2LE07
    • Q6FG40
    • Q9UC66

    Protein attributes for CKB Gene

    381 amino acids
    Molecular mass:
    42644 Da
    Quaternary structure:
    • Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

    Three dimensional structures from OCA and Proteopedia for CKB Gene

neXtProt entry for CKB Gene

Proteomics data for CKB Gene at MOPED

Post-translational modifications for CKB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys223, Lys242, Lys265, Lys298, Lys304, Lys307, and Lys313

Other Protein References for CKB Gene

Domains for CKB Gene


  • Contains 1 phosphagen kinase C-terminal domain.:
    • P12277
  • Contains 1 phosphagen kinase N-terminal domain.:
    • P12277
  • Belongs to the ATP:guanido phosphotransferase family.:
    • P12277
genes like me logo Genes that share domains with CKB: view

No data available for Gene Families for CKB Gene

Function for CKB Gene

Molecular function for CKB Gene

GENATLAS Biochemistry: creatine kinase,brain
UniProtKB/Swiss-Prot CatalyticActivity: ATP + creatine = ADP + phosphocreatine.
UniProtKB/Swiss-Prot Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Enzyme Numbers (IUBMB) for CKB Gene

Gene Ontology (GO) - Molecular Function for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004111 creatine kinase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CKB: view
genes like me logo Genes that share phenotypes with CKB: view

Animal Models for CKB Gene

MGI Knock Outs for CKB:

No data available for Transcription Factor Targeting and HOMER Transcription for CKB Gene

Localization for CKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKB Gene


Subcellular locations from

Jensen Localization Image for CKB Gene COMPARTMENTS Subcellular localization image for CKB gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 11487543
genes like me logo Genes that share ontologies with CKB: view

Pathways for CKB Gene

genes like me logo Genes that share pathways with CKB: view

Pathways by source for CKB Gene

Gene Ontology (GO) - Biological Process for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006600 creatine metabolic process TAS --
GO:0007420 brain development --
GO:0016310 phosphorylation IEA --
GO:0021762 substantia nigra development IEP 22926577
GO:0030644 cellular chloride ion homeostasis IEA --
genes like me logo Genes that share ontologies with CKB: view

Compounds for CKB Gene

(4) HMDB Compounds for CKB Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • ((amino(imino)methyl)(methyl)amino)acetate
  • Creatine phosphate

(1) Drugbank Compounds for CKB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (alpha-Methylguanido)acetic acid
57-00-1 target ligand

(29) Novoseek inferred chemical compound relationships for CKB Gene

Compound -log(P) Hits PubMed IDs
creatinine 85.8 143
tamoxifen methiodide 85.1 2
phosphocreatine 60.9 7
raloxifene 32.1 2
atp 31.5 8
genes like me logo Genes that share compounds with CKB: view

Transcripts for CKB Gene

Unigene Clusters for CKB Gene

Creatine kinase, brain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKB Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for CKB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CKB Gene

mRNA expression in normal human tissues for CKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKB Gene

SOURCE GeneReport for Unigene cluster for CKB Gene Hs.173724

genes like me logo Genes that share expressions with CKB: view

Orthologs for CKB Gene

This gene was present in the common ancestor of animals.

Orthologs for CKB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CKB 36
  • 99.74 (n)
  • 100 (a)
CKB 37
  • 100 (a)
(Bos Taurus)
Mammalia CKB 36
  • 93.18 (n)
  • 97.11 (a)
CKB 37
  • 97 (a)
(Canis familiaris)
Mammalia -- 37
  • 81 (a)
-- 37
  • 84 (a)
-- 37
  • 76 (a)
CKB 36
  • 94.23 (n)
  • 97.64 (a)
CKB 37
  • 98 (a)
(Mus musculus)
Mammalia Ckb 36
  • 90.46 (n)
  • 96.59 (a)
Ckb 16
Ckb 37
  • 97 (a)
(Monodelphis domestica)
Mammalia CKB 37
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 92 (a)
-- 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Ckb 36
  • 91.34 (n)
  • 96.59 (a)
(Gallus gallus)
Aves CKB 36
  • 79.44 (n)
  • 90.55 (a)
CKB 37
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 76 (a)
-- 37
  • 79 (a)
-- 37
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ckb 36
  • 74.1 (n)
  • 85.3 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1737 36
(Danio rerio)
Actinopterygii -- 36
ckba 37
  • 84 (a)
ckbb 36
  • 77.78 (n)
  • 85.83 (a)
ckbb 37
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Argk 37
  • 28 (a)
CG30274 37
  • 19 (a)
CG4546 37
  • 29 (a)
CG5144 37
  • 35 (a)
CG5144 38
  • 38 (a)
CG4546 38
  • 36 (a)
Argk 38
  • 38 (a)
(Caenorhabditis elegans)
Secernentea F11G11.13 37
  • 33 (a)
F32B5.1 37
  • 33 (a)
F44G3.2 37
  • 38 (a)
F46H5.3 37
  • 37 (a)
W10C8.5 37
  • 36 (a)
ZC434.8 37
  • 40 (a)
ZC434.8 38
  • 40 (a)
W10C8.5 38
  • 39 (a)
F32B5.1 38
  • 40 (a)
F44G3.2 38
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2638 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
CSA.6164 37
  • 69 (a)
Species with no ortholog for CKB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKB Gene

Gene Tree for CKB (if available)
Gene Tree for CKB (if available)

Paralogs for CKB Gene

Paralogs for CKB Gene

Selected SIMAP similar genes for CKB Gene using alignment to 7 proteins: Pseudogenes for CKB Gene

genes like me logo Genes that share paralogs with CKB: view

Variants for CKB Gene

Sequence variations from dbSNP and Humsavar for CKB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs12505 - 103,519,932(-) AGCTG(C/T)TCATC reference, missense
rs13558 -- 103,520,290(-) AGTCT(A/G)AGGAC reference, missense
rs1064582 -- 103,519,749(-) TAGAG(A/G)CTTCC utr-variant-3-prime
rs1136165 -- 103,521,843(-) CGCCG(A/C)GCCAT synonymous-codon, reference
rs1803283 -- 103,519,918(-) ATGGA(A/G)CAGCG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CKB Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
dgv1992n71 CNV Loss 21882294
nsv902300 CNV Loss 21882294
dgv1993n71 CNV Loss 21882294
dgv1994n71 CNV Loss 21882294
nsv827068 CNV Loss 20364138
esv29714 CNV Loss 19812545

Relevant External Links for CKB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CKB Gene

(2) University of Copenhagen DISEASES for CKB Gene

(43) Novoseek inferred disease relationships for CKB Gene

Disease -log(P) Hits PubMed IDs
fetal acidosis 54.7 1
bowel infarction 42.4 1
encephalopathies hypoxic-ischemic 39.2 1
anoxic encephalopathy 37.3 1
acute myocardial infarction 33.3 5

Relevant External Links for CKB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CKB: view

No data available for UniProtKB/Swiss-Prot for CKB Gene

Publications for CKB Gene

  1. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PMID: 16384981) Haines J.L. … Pericak-Vance M.A. (Invest. Ophthalmol. Vis. Sci. 2006) 3 23 49
  2. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. (PMID: 17148442) Debrincat M.A. … Hilton D.J. (J. Biol. Chem. 2007) 3 23 25
  3. Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. (PMID: 16424007) Balasubramani M. … Getzenberg R.H. (Cancer Res. 2006) 3 23
  4. Increased creatine kinase BB activity and CKB mRNA expression in patients with hematologic disorders: relation to methylation status of the CKB promoter. (PMID: 15996648) Ishikawa J. … Maekawa M. (Clin. Chim. Acta 2005) 3 23
  5. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. (PMID: 17683050) Cid C. … Alcazar A. (Proteomics 2007) 3 23

Products for CKB Gene

  • Addgene plasmids for CKB

Sources for CKB Gene

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