Aliases for CKB Gene
External Ids for CKB Gene
Previous HGNC Symbols for CKB Gene
Previous GeneCards Identifiers for CKB Gene
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CKB Gene
CKB (Creatine Kinase B) is a Protein Coding gene. Diseases associated with CKB include Prostate Rhabdomyosarcoma and Neonatal Hypoxic And Ischemic Brain Injury. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is CKMT1B.
UniProtKB/Swiss-Prot for CKB Gene
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.