Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKB Gene

protein-coding   GIFtS: 69
GCID: GC14M103986

Creatine Kinase, Brain


(Previous symbol: CKBB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Creatine Kinase, Brain1 2     EC 2.7.3.23 8
CKBB1 2 3 5     Creatine Kinase B-Type2
Creatine Kinase B Chain2 3     Creatine Kinase-B2
B-CK2 3     EC 2.7.38

External Ids:    HGNC: 19911   Entrez Gene: 11522   Ensembl: ENSG000001661657   OMIM: 1232805   UniProtKB: P122773   

Export aliases for CKB gene to outside databases

Previous GC identifers: GC14M101377 GC14M097801 GC14M101976 GC14M103055


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKB Gene:
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein
reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It
acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in
heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this
gene has been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for CKB Gene: 
CKB (creatine kinase, brain) is a protein-coding gene. Diseases associated with CKB include brain ischemia, and salmonellosis, and among its related super-pathways are Metabolic pathways and Creatine metabolism. GO annotations related to this gene include creatine kinase activity and ATP binding. An important paralog of this gene is CKM.

UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKB gene promoter:
         Max1   USF1   AP-2alpha isoform 3   USF-1:USF-2   AP-2alpha isoform 2   SRY   USF-1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKB promoter sequence
   Search SABiosciences Chromatin IP Primers for CKB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.32

CKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M103986:  view genomic region     (about GC identifiers)

Start:
103,985,996 bp from pter      End:
103,989,448 bp from pter
Size:
3,453 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277 (See protein sequence)
Recommended Name: Creatine kinase B-type  
Size: 381 amino acids; 42644 Da
Subunit: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and
myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for CKB:
3B6R (3D)        3DRB (3D)        3DRE (3D)    
Secondary accessions: A8K236 B2R5R4 Q2LE07 Q6FG40 Q9UC66

Explore the universe of human proteins at neXtProt for CKB: NX_P12277

Explore proteomics data for CKB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12277

  • 4/28 DME Specific Peptides for CKB (P12277) (see all 28)
     CPSNLGT  NEEDHLR  GGDDLDP  SEVELVQ 

    CKB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CKB Protein Expression
    REFSEQ proteins: NP_001814.2  
    ENSEMBL proteins: 
     ENSP00000299198   ENSP00000451680   ENSP00000450676   ENSP00000451426   ENSP00000451686  
     ENSP00000451904   ENSP00000451611  
    Reactome Protein details: P12277
    Human Recombinant Protein Products for CKB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CKB
    OriGene Protein Over-expression Lysate for CKB
    OriGene MassSpec for CKB 
    OriGene Custom Protein Services for CKB
    GenScript Custom Purified and Recombinant Proteins Services for CKB
    Novus Biologicals CKB Proteins
    Novus Biologicals CKB Lysate
    Sino Biological Recombinant Protein for CKB
    Sino Biological Cell Lysate for CKB 
    ProSpec Recombinant Protein for CKB
    Cloud-Clone Corp. Proteins for CKB 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    CKB for ontologies           About GeneDecksing



    CKB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CKB
    OriGene Custom Antibody Services for CKB
    GenScript Superior Antibodies for CKB
    Novus Biologicals CKB Antibodies
    Abcam antibodies for CKB
    Cloud-Clone Corp. Antibodies for CKB 
    ThermoFisher Antibody for CKB
    LSBio Antibodies in human, mouse, rat for CKB 

    Assay Products for CKB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CKB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CKB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CKB 
    Cloud-Clone Corp. CLIAs for CKB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000749 ATP-guanido_PTrfase
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P12277

    ProtoNet protein and cluster: P12277

    1 Blocks protein domain: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277
    Similarity: Belongs to the ATP:guanido phosphotransferase family
    Similarity: Contains 1 phosphagen kinase C-terminal domain
    Similarity: Contains 1 phosphagen kinase N-terminal domain


    CKB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCRB_HUMAN, P12277
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine
    phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large,
    fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine

         Genatlas biochemistry entry for CKB:
    creatine kinase,brain

         Enzyme Numbers (IUBMB): EC 2.7.3.21 2 EC 2.7.32

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004111creatine kinase activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    CKB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CKB:
     Decreased 12E8 tau but not tot 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ckb):
     behavior/neurological  growth/size  nervous system 

    CKB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ckbtm1Bew for CKB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CKB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CKB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKB
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CKB:
    hsa-miR-3926 hsa-miR-3613-3p hsa-miR-205* hsa-miR-618 hsa-miR-139-5p hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidCKB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CKB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CKB
    Sirion Biotech Customized adenovirus for overexpression of CKB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CKB (see all 7)
    OriGene ORF clones in mouse, rat for CKB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKB (NM_176875)
    Sino Biological Human cDNA Clone for CKB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKB
    Sirion Biotech Customized lentivirus for stable overexpression of CKB 
                         Customized lentivirus expression plasmids for stable overexpression of CKB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CKB
    Search LifeMap BioReagents cell lines for CKB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CKB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2creatine-phosphate biosynthesis
    creatine-phosphate biosynthesis0.38
    Creatine metabolism0.38
    3Arginine and proline metabolism
    Arginine and proline metabolism0.35
    Urea cycle and metabolism of amino groups0.35
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    5Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Abacavir Pathway, Pharmacokinetics/Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CKB
        creatine-phosphate biosynthesis
    Urea cycle and metabolism of amino groups


    3        Reactome Pathways for CKB
        Creatine metabolism
    Metabolism
    Metabolism of amino acids and derivatives

    1 PharmGKB Pathway for CKB
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics

    2         Kegg Pathways  (Kegg details for CKB):
        Arginine and proline metabolism
    Metabolic pathways


    CKB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/70 Interacting proteins for CKB (P122771, 2, 3 ENSP000002991984) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, 3, ENSP000002265744MINT-48546 I2D: score=1 STRING: ENSP00000226574
    TAB1Q157502, 3MINT-8260064 I2D: score=2 
    CGBP012333I2D: score=1 
    CGB5P012333I2D: score=1 
    CGB7P012333I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600creatine metabolic process TAS--
    GO:0007420brain development IEA--
    GO:0030644cellular chloride ion homeostasis IEA--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CKB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CKB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKB (KCRB)

    4 HMDB Compounds for CKB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Creatine((amino(imino)methyl)(methyl)amino)acetate (see all 17)57-00-1--
    PhosphocreatineCreatine phosphate (see all 15)67-07-2--

    1 DrugBank Compound for CKB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Creatine(alpha-Methylguanido)acetic acid (see all 6)57-00-1targetligand17036164 17148442 16875703 1731757

    10/29 Novoseek inferred chemical compound relationships for CKB gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 85.8 294 19337362 (6), 11804344 (4), 9547297 (4), 7781040 (3) (see all 99)
    tamoxifen methiodide 85.1 2 11384866 (1), 9010344 (1)
    phosphocreatine 60.9 9 8923416 (3), 20520825 (2), 1531784 (1), 8940627 (1)
    raloxifene 32.1 2 11384866 (1), 9010344 (1)
    atp 31.5 11 19333390 (2), 17029789 (1), 15892163 (1), 1950416 (1) (see all 7)
    lactate 29.6 18 1541099 (2), 8634377 (2), 7841274 (2), 17934974 (1) (see all 10)
    tamoxifen 26.3 2 11384866 (1), 9010344 (1)
    isocitrate 23.8 2 8567810 (1), 16912971 (1)
    aspartate 21.8 5 7841727 (1), 18552983 (1), 1601350 (1), 8634377 (1) (see all 5)
    percoll 16.5 1 8833742 (1)

    Search CenterWatch for drugs/clinical trials and news about CKB / KCRB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CKB gene: 
    NM_001823.4  

    Unigene Cluster for CKB:

    Creatine kinase, brain
    Hs.173724  [show with all ESTs]
    Unigene Representative Sequence: BC040666
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348956(uc001ynf.2) ENST00000554989 ENST00000554282 ENST00000553528
    ENST00000553652 ENST00000553610 ENST00000555039 ENST00000555366 ENST00000557569
    ENST00000554426 ENST00000553878 ENST00000557287 ENST00000555659 ENST00000554705
    ENST00000555770 ENST00000557530 ENST00000553994
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKB
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CKB:
    hsa-miR-3926 hsa-miR-3613-3p hsa-miR-205* hsa-miR-618 hsa-miR-139-5p hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidCKB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CKB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKB
    Clone
    Products:
         
    OriGene clones in human, mouse for CKB (see all 7)
    OriGene ORF clones in mouse, rat for CKB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CKB (NM_176875)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKB
    Sirion Biotech Customized lentivirus for stable overexpression of CKB 
                         Customized lentivirus expression plasmids for stable overexpression of CKB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CKB
    OriGene qSTAR qPCR primer pairs in human, mouse for CKB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CKB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKB

    Additional mRNA sequence: 

    AK290101.1 AK298198.1 AK312282.1 BC001190.1 BC004914.2 BC008323.1 BC010002.2 BC019259.1 
    BC019281.1 BC040666.2 BC111085.1 CR542268.1 L47647.1 M16364.1 M16451.1 

    24/51 DOTS entries (see all 51):

    DT.100688053  DT.100856085  DT.40291664  DT.97795378  DT.100656447  DT.100679969  DT.91799070  DT.100772203 
    DT.40310087  DT.120747593  DT.91670517  DT.95302733  DT.102837438  DT.87017656  DT.95309524  DT.100641046 
    DT.120747483  DT.120747499  DT.91765918  DT.100679979  DT.91982828  DT.95309516  DT.97864534  DT.100846484 

    24/1026 AceView cDNA sequences (see all 1026):

    AW191863 BQ636912 CB155552 CR622478 BQ958567 BQ637571 BQ637572 AU104788 
    BF339980 BM832696 AV709913 BE740676 AA365761 CR612287 BU726169 BM721647 
    BU742288 CB268254 NM_001823 CF127987 CB117129 BQ943624 BF725281 CR604286 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CKB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                          -                 -                 -     -     -           -                                 
    SP2:                                            -                 -     -     -           -     -                           
    SP3:              -           -                 -                                                                           
    SP4:                                                                                      -                                 
    SP5:                          -                 -                                                                           


    ECgene alternative splicing isoforms for CKB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKB expression in normal human tissues (normalized intensities)      CKB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCCCTGAT
    CKB Expression
    About this image


    CKB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Human Astrocytes   
             brain/forebrain/telencephalon   
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             HyStem+BMP4-induced 4D20.8 cells
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
             skeleton/pectoral girdle and thoracic body wall/sternum   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Retina
             Human Non-Pigment Ciliary Epithelial Cells (HNPCEpiC)   
     
     Nose (Sensory Organs)    fully expand to see all 4 entries
             sensory organ/nose   

    See CKB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKB

    SOURCE GeneReport for Unigene cluster: Hs.173724
        SABiosciences Expression via Pathway-Focused PCR Arrays including CKB: 
              Estrogen Receptor Signaling in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CKB
    OriGene qSTAR qPCR primer pairs in human, mouse for CKB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CKB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CKB gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckb1 , 5 creatine kinase, brain1, 5 90.46(n)1
    96.59(a)1
      12 (61.09 cM)5
    127091  NM_021273.41  NP_067248.11 
     1116693555 
    chicken
    (Gallus gallus)
    Aves CKB1 creatine kinase, brain 79.44(n)
    90.55(a)
      396248  NM_205310.1  NP_990641.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    CKB6
    (see all 3)
    Uncharacterized protein
    (see all 3)
    82(a)
    79(a)
    (see all 3)
    possible ortholog
    1 ↔ 1
    (see all 3)
    GL343267.1(1341512-1341911)
    GL343232.1(117323-137732)
    zebrafish
    (Danio rerio)
    Actinopterygii AY055849.12   -- 79.33(n)   140744  AY055849.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Argk3 phosphorylation arginine kinase 38(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for CKB (if available)
    TreeFam Gene Tree for CKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CKB gene
    CKM2  CKMT1B2  CKMT22  CKMT1A2  
    4 SIMAP similar genes for CKB using alignment to 7 protein entries:     KCRB_HUMAN (see all proteins):
    CKM    CKMT1B    CKMT1A    CKMT2

    CKB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CKB
    PGOHUM00000261881


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in CKB are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344715671,2
    C,F,H--103985632(-) TCCAAC/TTGGCT 1 -- ds50018Minor allele frequency- T:0.00NS NA 686
    rs360891681,2
    C,F--103985726(-) TGGCAC/TGTTCC 1 -- ds50017Minor allele frequency- T:0.04NS WA 296
    rs775424271,2
    F--103985771(+) TCAGGC/TCTGGA 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs356832151,2
    C,F--103985795(-) CATGGG/AAGAGA 1 -- ds50017Minor allele frequency- A:0.04NS WA 310
    rs1469548541,2
    --103985812(+) CCTGCA/GCAGCC 1 -- ds50010--------
    rs342447281,2
    C,F--103985819(-) TCTATC/TGGGCT 1 -- ds50016Minor allele frequency- T:0.04NS WA 308
    rs353584071,2
    C,F--103985868(-) CCACTC/GTGTTC 1 -- ds50016Minor allele frequency- G:0.01NS NA 310
    rs753557221,2
    C--103985901(+) TCTCAC/GAGAAG 1 -- ds50010--------
    rs1118670521,2
    C--103986003(+) GACGCT/AGGCAG 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs1129745591,2
    C--103986155(+) CAGGCT/AATAAG 1 -- ut311Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for CKB (103985996 - 103989448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CKB:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1992n71CNV Loss21882294
    nsv832883CNV Loss17160897
    dgv1993n71CNV Loss21882294
    nsv827068CNV Loss20364138
    esv29714CNV Loss19812545
    nsv902300CNV Loss21882294
    dgv1994n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): CKB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CKB
    DNA2.0 Custom Variant and Variant Library Synthesis for CKB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123280    OMIM disorders: --

    20/53 diseases for CKB (see all 53):    About MalaCards
    brain ischemia    salmonellosis    head injury    bacterial meningitis
    meningitis    ischemia    brain injury    traumatic brain injury
    duchenne muscular dystrophy    acute myocardial infarction    giant cell tumor    osteopetrosis
    pick's disease    myocardial infarction    neurologic diseases    endocarditis
    myotonic dystrophy    age related macular degeneration    hypoglycemia    macular degeneration

    2 diseases from the University of Copenhagen DISEASES database for CKB:
    Myocardial infarction     Prostate rhabdomyosarcoma

    CKB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/43 Novoseek inferred disease relationships for CKB gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fetal acidosis 54.7 1 7823262 (1)
    bowel infarction 42.4 1 1935497 (1)
    encephalopathies hypoxic-ischemic 39.2 2 12736385 (1)
    anoxic encephalopathy 37.3 1 8509798 (1)
    acute myocardial infarction 33.3 7 8120516 (3), 1511070 (1), 2096250 (1)
    meningitis bacterial 33.3 1 7841727 (1)
    brain ischemia 29.7 1 8509798 (1)
    asphyxia 28.7 7 10732307 (4), 12736385 (2), 2303153 (1)
    small cell lung cancer 27.1 5 1645850 (1), 1645171 (1), 7657349 (1), 1766488 (1)
    involvement cns 24.6 3 8402452 (3)

    Genetic Association Database (GAD): CKB
    Human Genome Epidemiology (HuGE) Navigator: CKB (20 documents)

    Export disorders for CKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CKB gene, integrated from 9 sources (see all 260):
    (articles sorted by number of sources associating them with CKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. (PubMed id 17148442)1, 7, 9 Debrincat M.A....Hilton D.J. (2007)
    2. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PubMed id 16384981)1, 4, 9 Haines J.L....Pericak-Vance M.A. (2006)
    3. Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex. (PubMed id 18977227)1, 2 Bong S.M....Hwang K.Y. (2008)
    4. Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase. (PubMed id 17036164)1, 7 Burklen T.S....Wallimann T. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Determination of the catalytic site of creatine kinase by site- directed mutagenesis. (PubMed id 8186255)1, 2 Lin L.... Ma T.S. (1994)
    7. Complete nucleotide sequence of the human creatine kinase B gene. (PubMed id 2771648)1, 2 Mariman E.C.M.... Wieringa B. (1989)
    8. Isolation of a functional human gene for brain creatine kinase. (PubMed id 2828370)1, 2 Daouk G.H.... Schimmel P. (1988)
    9. Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci. (PubMed id 2883200)1, 2 Kaye F.J.... Sausville E.A. (1987)
    10. Structure and expression of the human creatine kinase B gene. (PubMed id 3692484)1, 2 Mariman E.C.M....Wieringa B. (1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1152 HGNC: 1991 AceView: CKB Ensembl:ENSG00000166165 euGenes: HUgn1152
    ECgene: CKB Kegg: 1152 H-InvDB: CKB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CKB Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ckb/
    Wikipedia http://en.wikipedia.org/wiki/Creatine_kinase
    Wikipedia http://en.wikipedia.org/wiki/CKB_(gene)

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CKB gene:
    Search GeneIP for patents involving CKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CKB   OriGene RNAi products in human, mouse, rat for CKB  
     OriGene qPCR primer pairs and template standards for CKB   OriGene Protein Over-expression Lysate for CKB  
     OriGene MassSpec something-or-other for CKB   OriGene clones in human, mouse for CKB  
     OriGene qSTAR qPCR primer pairs in human, mouse for CKB   OriGene Purified Protein for CKB  
     OriGene ORF clones in mouse, rat for CKB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CKB   OriGene Custom Protein Services for CKB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CKB
     QIAGEN SeqTarget long-range PCR primers for resequencing CKB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKB
     GenScript Custom Purified and Recombinant Proteins Services for CKB GenScript cDNA clones with any tag delivered in your preferred vector for CKB
     GenScript Custom Assay Services for CKB GenScript Superior Antibodies for CKB
     GenScript Custom overexpressing Cell Line Services for CKB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CKB promoter
     Search Chromatin IP Primers for CKB
     RT2 qPCR Primer Assay in human, mouse, rat CKB
     GNC Network for CKB
     SABiosciences PCR Arrays including human, mouse, rat CKB
     Search Tocris compounds for CKB (KCRB)
     Proteins and Antibodies for CKB
     Cell Lysates for CKB
     cDNA Clones for CKB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CKB antibodies
     CKB proteins
     CKB lysates
     Antibodies for CKB
     See all of Abcam's Antibodies, Kits and Proteins for CKB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CKB




     Proteins for CKB
     Antibodies for CKB
     ELISAs for CKB
     CLIAs for CKB
     Search LifeMap BioReagents cell lines for CKB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKB
     SwitchGear 3'UTR luciferase reporter plasmids for CKB
     SwitchGear Promoter luciferase reporter plasmids for CKB
     ThermoFisher Antibody for CKB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CKB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CKB
    Customized:
     lentivirus for stable overexpression of CKB
     lentivirus expression plasmids for stable overexpression of CKB
     adenovirus for overexpression of CKB
     LSBio Antibodies in human, mouse, rat for CKB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CKB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4