Aliases for CKB Gene
External Ids for CKB Gene
Previous Symbols for CKB Gene
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CKB Gene
CKB (Creatine Kinase, Brain) is a Protein Coding gene. Diseases associated with CKB include prostate rhabdomyosarcoma and brain ischemia. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include creatine kinase activity. An important paralog of this gene is CKMT1B.
UniProtKB/Swiss-Prot for CKB Gene
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa