Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CKB Gene

protein-coding GIFtS: 67
GCID: GC14M103986

creatine kinase, brain

(Previous symbol: CKBB)

Explore 62 diseases affiliated with
CKB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Creatine Kinase, Brain¹ ²		EC 2.7.3.2³ ⁸
CKBB¹ ² ³ ⁵		Creatine Kinase B-Type²
Creatine Kinase B Chain² ³		Creatine Kinase-B²
B-CK² ³		EC 2.7.3⁸

External Ids:	HGNC: 1991¹	Entrez Gene: 1152²	Ensembl: ENSG00000166165⁷	OMIM: 123280⁵	UniProtKB: P12277³

Export aliases for CKB gene to outside databases

Previous GC identifers: GC14M101377 GC14M097801 GC14M101976 GC14M103055

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKB:

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly

catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a

homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The

encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been

characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277

Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).

Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy

demands, such as skeletal muscle, heart, brain and spermatozoa

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CKB gene promoter:
Max1 USF1 AP-2alpha isoform 3 USF-1:USF-2 AP-2alpha isoform 2 SRY USF-1 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKB promoter sequence

Search SABiosciences Chromatin IP Primers for CKB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.32 HGNC cytogenetic band: 14q32.32

CKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKB gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M103986: view genomic region (about GC identifiers)

Start:	103,985,996 bp from pter	End:	103,989,448 bp from pter
Size:	3,453 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277 (See protein sequence)

Recommended Name: Creatine kinase B-type

Size: 381 amino acids; 42644 Da

Subunit: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB

existing in myocardium, and BB existing in many tissues, especially brain

Subcellular location: Cytoplasm

3 PDB 3D structures from and Proteopedia for CKB:

3B6R (3D)

3DRB (3D)

3DRE (3D)

Secondary accessions: A8K236 B2R5R4 Q2LE07 Q6FG40 Q9UC66

Explore the universe of human proteins at neXtProt for CKB: NX_P12277

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P12277

4/28 DME Specific Peptides for CKB (P12277) (see all 28)

CPSNLGT

NEEDHLR

GGDDLDP

SEVELVQ

CKB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001814.2

ENSEMBL proteins:

ENSP00000299198 ENSP00000451680 ENSP00000450676 ENSP00000451426 ENSP00000451686

ENSP00000451904 ENSP00000451611

Reactome Protein details: P12277
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CKB OriGene Protein Over-expression Lysate: CKB OriGene Custom Protein Services for CKB
	GenScript Custom Purified and Recombinant Proteins Services for CKB
	Novus Biologicals CKB Proteins Novus Biologicals CKB Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CKB
	Uscn Proteins for CKB

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--

CKB for ontologies About GeneDecksing

CKB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 4): CKB OriGene Custom Antibody Services for CKB
	GenScript Superior Antibodies for CKB
	Novus Biologicals CKB Antibodies
	Abcam antibodies for CKB
	Uscn Antibodies for CKB
	ThermoFisher Antibody for CKB

Assay Products for CKB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CKB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CKB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CKB for domains About GeneDecksing

5 InterPro domains/families:

IPR000749 ATP-guanido_PTrfase

IPR014746 Gln_synth/guanido_kin_cat_dom

IPR022413 ATP-guanido_PTrfase_N

IPR022415 ATP-guanido_PTrfase_AS

IPR022414 ATP-guanido_PTrfase_cat

Graphical View of Domain Structure for InterPro Entry P12277

ProtoNet protein and cluster: P12277

1 Blocks protein family: IPB000749 ATP:guanido phosphotransferase

UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277

Similarity: Belongs to the ATP:guanido phosphotransferase family

Similarity: Contains 1 phosphagen kinase C-terminal domain

Similarity: Contains 1 phosphagen kinase N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KCRB_HUMAN, P12277

Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).

Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy

demands, such as skeletal muscle, heart, brain and spermatozoa

Catalytic activity: ATP + creatine = ADP + phosphocreatine

Genatlas biochemistry entry for CKB:

creatine kinase,brain

Enzyme Numbers (IUBMB): EC 2.7.3.2¹ ² EC 2.7.3²

miRNA Products:		OriGene 3'-UTR Clone: CKB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKB
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CKB:
		hsa-miR-3926 hsa-miR-3613-3p hsa-miR-205* hsa-miR-618 hsa-miR-139-5p hsa-miR-1258
		SwitchGear 3'UTR luciferase reporter plasmid: CKB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKB (see all 7) OriGene shRNA RFP: CKB OriGene siRNA: CKB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CKB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKB OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKB (NM_176875)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CKB
		Search LifeMap BioReagents cell lines for CKB

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CKB

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004111	creatine kinase activity	IEA	--
GO:0005515	protein binding	IPI	19060904
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	--	--

CKB for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CKB:

Decreased 12E8 tau but not tot

Animal Models:
Mouse knock-out Ckb^tm1Bew for CKB
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ckb):

behavior/neurological

growth/size

nervous system

CKB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Arginine and proline metabolism

Arginine and proline metabolism

1.00

Urea cycle and metabolism of amino groups

0.36

creatine-phosphate biosynthesis

creatine-phosphate biosynthesis

1.00

Creatine metabolism

0.38

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for CKB

	creatine-phosphate biosynthesis
	Urea cycle and metabolism of amino groups

3 Reactome Pathways for CKB

	Creatine metabolism
	Metabolism
	Metabolism of amino acids and derivatives

2 Kegg Pathways (Kegg details for CKB):

	Arginine and proline metabolism
	Metabolic pathways

CKB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CKB

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/70 Interacting proteins for CKB (P12277^{1, 2, 3} ENSP00000299198⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838²^,³, ENSP00000226574⁴	MINT-48546 I2D: score=1 STRING: ENSP00000226574
TAB1	Q15750²^,³	MINT-8260064 I2D: score=2
CGB	P01233³	I2D: score=1
CGB5	P01233³	I2D: score=1
CGB7	P01233³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006600	creatine metabolic process	TAS	--
GO:0007420	brain development	IEA	--
GO:0030644	cellular chloride ion homeostasis	IEA	--
GO:0034641	cellular nitrogen compound metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

CKB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CKB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CKB

4 HMDB Compounds for CKB About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Creatine	((amino(imino)methyl)(methyl)amino)acetate (see all 17)	57-00-1	--
Phosphocreatine	Creatine phosphate (see all 15)	67-07-2	--

1 DrugBank Compound for CKB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Creatine	(alpha-Methylguanido)acetic acid (see all 6)	57-00-1	target	ligand	17036164 17148442 16875703 1731757

10/29 Novoseek chemical compound relationships for CKB gene (see all 29) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
creatinine	85.8	294	19337362 (6), 11804344 (4), 9547297 (4), 7781040 (3) (see all 99)
tamoxifen methiodide	85.1	2	11384866 (1), 9010344 (1)
phosphocreatine	60.9	9	8923416 (3), 20520825 (2), 1531784 (1), 8940627 (1)
raloxifene	32.1	2	11384866 (1), 9010344 (1)
atp	31.5	11	19333390 (2), 17029789 (1), 15892163 (1), 1950416 (1) (see all 7)
lactate	29.6	18	1541099 (2), 8634377 (2), 7841274 (2), 17934974 (1) (see all 10)
tamoxifen	26.3	2	11384866 (1), 9010344 (1)
isocitrate	23.8	2	8567810 (1), 16912971 (1)
aspartate	21.8	5	7841727 (1), 18552983 (1), 1601350 (1), 8634377 (1) (see all 5)
percoll	16.5	1	8833742 (1)

Search CenterWatch for drugs/clinical trials and news about CKB / KCRB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CKB gene:

NM_001823.4

Unigene Cluster for CKB:

Creatine kinase, brain

Hs.173724 [show with all ESTs]

Unigene Representative Sequence: BC040666

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000348956(uc001ynf.2) ENST00000554989 ENST00000554282 ENST00000553528

ENST00000553652 ENST00000553610 ENST00000555039 ENST00000555366 ENST00000557569

ENST00000554426 ENST00000553878 ENST00000557287 ENST00000555659 ENST00000554705

ENST00000555770 ENST00000557530 ENST00000553994

miRNA Products:		OriGene 3'-UTR Clone: CKB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKB
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CKB:
		hsa-miR-3926 hsa-miR-3613-3p hsa-miR-205* hsa-miR-618 hsa-miR-139-5p hsa-miR-1258
		SwitchGear 3'UTR luciferase reporter plasmid: CKB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKB (see all 7) OriGene shRNA RFP: CKB OriGene siRNA: CKB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKB OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKB (NM_176875)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CKB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKB

Additional cDNA sequence:

AK290101.1 AK298198.1 AK312282.1 BC001190.1 BC004914.2 BC008323.1 BC010002.2 BC019259.1

BC019281.1 BC040666.2 BC111085.1 CR542268.1 L47647.1 M16364.1 M16451.1

24/53 DOTS entries (see all 53):

DT.100688053 DT.100856085 DT.97795378 DT.40291664 DT.100656447 DT.100679969 DT.91799070 DT.100772203

DT.40310087 DT.120747593 DT.102837438 DT.91670517 DT.95302733 DT.95309524 DT.87017656 DT.100641046

DT.120747483 DT.120747499 DT.91765918 DT.95309516 DT.100679979 DT.91982828 DT.97864534 DT.100846484

24/1026 AceView cDNA sequences (see all 1026):

CR602935 NM_001823 CB268254 BM684665 AU104790 BU932063 BQ943624 CR604078

AU104802 BQ924133 CR594482 BG570286 BI333755 F04008 CB154849 BM662176

CR620989 BQ638225 BM920629 CB156444 BP347556 BM690883 CD674612 AA338423

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CKB (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	·	8c
SP1:									-						-						-		-		-				-
SP2:															-						-		-		-				-		-
SP3:					-				-						-
SP4:																													-
SP5:									-						-

ECgene alternative splicing isoforms for CKB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CKB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCCCTGAT

About this image

CKB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Gut Tube

Gut Tube

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See CKB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CKB

SOURCE GeneReport for Unigene cluster: Hs.173724

SABiosciences Expression via Pathway-Focused PCR Arrays including CKB:

Estrogen Receptor Signaling in human mouse rat

Amino Acid Metabolism I in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CKB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKB

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CKB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CKB gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CKB¹	creatine kinase, brain	79.44(n) 90.55(a)		396248 NM_205310.1 NP_990641.1
lizard (Anolis carolinensis)	Reptilia	CKB⁶ -- (see all 3)	--	91(a) 82(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343232.1(119641-137426) GL343267.1(1341512-1341911)
zebrafish (Danio rerio)	Actinopterygii	AY055849.1²	--	79.33(n)		140744 AY055849.1
fruit fly (Drosophila melanogaster)	Insecta	Argk³	phosphorylation arginine kinase	38(a) (best of 3)		--
worm (Caenorhabditis elegans)	Secernentea	F32B5.1³	phosphotransferase	40(a) (best of 4)		I(2700421-2702083) --

ENSEMBL Gene Tree for CKB (if available)
TreeFam Gene Tree for CKB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CKB gene

CKM² CKMT1B² CKMT2² CKMT1A²

4 SIMAP similar genes for CKB using alignment to 7 protein entries: KCRB_HUMAN (see all proteins):

CKM CKMT1B CKMT1A CKMT2

CKB for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CKB
PGOHUM00000261881

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34471567^1,2	C,F,H,	--	103985632(-)	`TCCAAC/TTGGCT`	1	--	ds500¹		8		NS NA	686
rs36089168^1,2	C,F,	--	103985726(-)	`TGGCAC/TGTTCC`	1	--	ds500¹		7		NS WA	296
rs77542427^1,2		--	103985771(+)	`TCAGGC/TCTGGA`	1	--	ds500¹		1		EA	120
rs35683215^1,2	C,F,	--	103985795(-)	`CATGGG/AAGAGA`	1	--	ds500¹		7		NS WA	310
rs146954854^1,2		--	103985812(+)	`CCTGCA/GCAGCC`	1	--	ds500¹		0	--	--	--	--
rs34244728^1,2	C,F,	--	103985819(-)	`TCTATC/TGGGCT`	1	--	ds500¹		6		NS WA	308
rs35358407^1,2	C,F,	--	103985868(-)	`CCACTC/GTGTTC`	1	--	ds500¹		6		NS NA	310
rs75355722^1,2	C	--	103985901(+)	`TCTCAC/GAGAAG`	1	--	ds500¹		0	--	--	--	--
rs111867052^1,2	C	--	103986003(+)	`GACGCT/AGGCAG`	1	--	ut3¹		1		CSA	1
rs112974559^1,2	C	--	103986155(+)	`CAGGCT/AATAAG`	1	--	ut3¹		1		CSA	1

HapMap Linkage Disequilibrium report for CKB (103985996 - 103989448 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CKB
1 CNV: 66717
Human Gene Mutation Database (HGMD): CKB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKB

DNA2.0 Custom Variant and Variant Library Synthesis for CKB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CKB for disorders           About GeneDecksing

OMIM gene information: 123280    OMIM disorders: --

20/62 diseases for CKB (see all 62):    About MalaCards

acute myocardial infarction brain injury macular degeneration urolithiasis

muscular dystrophy brain ischemia bacterial meningitis myotonic dystrophy

giant cell tumor head injury acute lymphoblastic leukemia meningitis

dilated cardiomyopathy lymphoblastic leukemia maculopathy epithelial ovarian cancer

1 disease from the University of Copenhagen DISEASES database for CKB:

Myocardial infarction

10/43 Novoseek disease relationships for CKB gene (see all 43) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fetal acidosis	54.7	1	7823262 (1)
bowel infarction	42.4	1	1935497 (1)
encephalopathies hypoxic-ischemic	39.2	2	12736385 (1)
anoxic encephalopathy	37.3	1	8509798 (1)
acute myocardial infarction	33.3	7	8120516 (3), 1511070 (1), 2096250 (1)
meningitis bacterial	33.3	1	7841727 (1)
brain ischemia	29.7	1	8509798 (1)
asphyxia	28.7	7	10732307 (4), 12736385 (2), 2303153 (1)
small cell lung cancer	27.1	5	1645850 (1), 1645171 (1), 7657349 (1), 1766488 (1)
involvement cns	24.6	3	8402452 (3)

Genetic Association Database (GAD): CKB
Human Genome Epidemiology (HuGE) Navigator: CKB (20 documents)

Export disorders for CKB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CKB gene, integrated from 9 sources (see all 255):
(articles sorted by number of sources associating them with CKB)

Utopia: connect your pdf to the dynamic
world of online information

Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. (PubMed id 17148442)^{1, 7, 9} Debrincat M.A....Hilton D.J. (2007)
Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PubMed id 16384981)^{1, 4, 9} Haines J.L....Pericak-Vance M.A. (2006)
Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex. (PubMed id 18977227)^{1, 2} Bong S.M....Hwang K.Y. (2008)
Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase. (PubMed id 17036164)^{1, 7} Burklen T.S....Wallimann T. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Determination of the catalytic site of creatine kinase by site- directed mutagenesis. (PubMed id 8186255)^{1, 2} Lin L.... Ma T.S. (1994)
Complete nucleotide sequence of the human creatine kinase B gene. (PubMed id 2771648)^{1, 2} Mariman E.C.M.... Wieringa B. (1989)
Isolation of a functional human gene for brain creatine kinase. (PubMed id 2828370)^{1, 2} Daouk G.H.... Schimmel P. (1988)
Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci. (PubMed id 2883200)^{1, 2} Kaye F.J.... Sausville E.A. (1987)
Structure and expression of the human creatine kinase B gene. (PubMed id 3692484)^{1, 2} Mariman E.C.M....Wieringa B. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1152	HGNC: 1991	AceView: CKB	Ensembl:ENSG00000166165	euGenes: HUgn1152
ECgene: CKB	Kegg: 1152	H-InvDB: CKB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CKB	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/ckb/
Wikipedia	http://en.wikipedia.org/wiki/Creatine_kinase
Wikipedia	http://en.wikipedia.org/wiki/CKB_(gene)

Intellectual Property for CKB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CKB gene:
Search GeneIP for patents involving CKB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for CKB		OriGene shRNA RFP for CKB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKB
	OriGene Protein Over-expression Lysate for CKB		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CKB		OriGene 3'-UTR Clone for CKB
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKB		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKB
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CKB		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CKB		OriGene Custom Protein Services for CKB
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CKB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKB

	GenScript Custom Purified and Recombinant Proteins Services for CKB		GenScript cDNA clones with any tag delivered in your preferred vector for CKB
	GenScript Custom Assay Services for CKB		GenScript Superior Antibodies for CKB
	GenScript Custom overexpressing Cell Line Services for CKB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CKB promoter
	Search Chromatin IP Primers for CKB
	RT² qPCR Primer Assay in human, mouse, rat CKB
	GNC Network for CKB
	SABiosciences PCR Arrays including human, mouse, rat CKB

Search Tocris compounds for CKB

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CKB antibodies
	CKB proteins
	CKB lysates

	Antibodies for CKB
	See all of Abcam's Antibodies, Kits and Proteins for CKB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CKB

CKB Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CKB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CKB

	SwitchGear 3'UTR luciferase reporter plasmids for CKB
	SwitchGear Promoter luciferase reporter plasmids for CKB

ThermoFisher Antibody for CKB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKB

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CKB gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CKB Gene

creatine kinase, brain

Aliases
for CKB gene

Summaries
for CKB gene

Genomic Views
for CKB gene

Proteins
for CKB gene

Protein Domains /
Families
for CKB gene

Function
for CKB gene

Pathways & Interactions
for CKB gene

Drugs & Compounds
for CKB gene

Transcripts
for CKB gene

Expression
for CKB gene

Orthologs
for CKB gene

Paralogs
for CKB gene

Genomic Variants
for CKB gene

Disorders / Diseases
for CKB gene

Publications
for CKB gene

External Searches for CKB gene

Genome Databases showing CKB gene

Other Databases showing CKB gene

Specialized Databases showing CKB gene

Intellectual Property
for CKB gene

Products
for CKB gene

View Random Gene

Neurological Disorders
Colon Cancer
Urolithiasis
involvement CNS
Meningitis Bacterial
Acute myocardial infarction
Carcinoma
INFARCT
LUNG CARCINOMA
Leukemia
Alzheimers Disease
Intoxication
Ischemia
Asphyxia
Breast Cancer
Subarachnoid Hemorrhage
NSCLC
Brain Ischemia
Adenocarcinoma
CONGENITAL HEART DISEASE
cell damage
ENCEPHALOPATHY
Cancer
Encephalopathies Hypoxic-Ischemic
Mitral Regurgitation
small cell lung cancer
Fetal acidosis
Myocardial Infarction
RENAL STONE
Anoxic Encephalopathy
Ovarian Cancer
Shock
Bowel infarction
Colorectal Cancer
Lung diseases
STROKE
Cerebral Ischemia
Tumors
Glioblastoma
URETERAL STONE
Cardiac Arrest
Endometrial Cancer
CNS Diseases

Advanced Search

Export list of displayed genes

CKB Gene

creatine kinase, brain

Aliasesfor CKB gene

Summariesfor CKB gene

Genomic Viewsfor CKB gene

Proteinsfor CKB gene

Protein Domains /Familiesfor CKB gene

Functionfor CKB gene

Pathways & Interactionsfor CKB gene

Drugs & Compoundsfor CKB gene

Transcriptsfor CKB gene

Expression for CKB gene

Orthologsfor CKB gene

Paralogsfor CKB gene

Genomic Variantsfor CKB gene

Disorders / Diseasesfor CKB gene

Publicationsfor CKB gene

External Searches for CKB gene

Genome Databases showing CKB gene

Other Databases showing CKB gene

Specialized Databases showing CKB gene

Intellectual Propertyfor CKB gene

Productsfor CKB gene

View Random Gene

Aliases
for CKB gene

Summaries
for CKB gene

Genomic Views
for CKB gene

Proteins
for CKB gene

Protein Domains /
Families
for CKB gene

Function
for CKB gene

Pathways & Interactions
for CKB gene

Drugs & Compounds
for CKB gene

Transcripts
for CKB gene

Expression
for CKB gene

Orthologs
for CKB gene

Paralogs
for CKB gene

Genomic Variants
for CKB gene

Disorders / Diseases
for CKB gene

Publications
for CKB gene

Intellectual Property
for CKB gene

Products
for CKB gene