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Aliases for CKAP5 Gene

Aliases for CKAP5 Gene

  • Cytoskeleton Associated Protein 5 2 3 5
  • Colonic And Hepatic Tumor Overexpressed Gene Protein 3 4
  • Ch-TOG 3 4
  • Colonic And Hepatic Tumor Over-Expressed Gene Protein 3
  • EC 3.1.1.29 63
  • EC 2.7.7.6 63
  • KIAA0097 4
  • CHTOG 3
  • MSPS 3
  • TOGp 3
  • TOG 3

External Ids for CKAP5 Gene

Previous GeneCards Identifiers for CKAP5 Gene

  • GC11M046722
  • GC11M046470
  • GC11M046815
  • GC11M048068
  • GC11M048794
  • GC11M049892
  • GC11M047086
  • GC11M047930

Summaries for CKAP5 Gene

Entrez Gene Summary for CKAP5 Gene

  • This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for CKAP5 Gene

CKAP5 (Cytoskeleton Associated Protein 5) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include binding and endonuclease activity.

UniProtKB/Swiss-Prot for CKAP5 Gene

  • Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles.

Gene Wiki entry for CKAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP5 Gene

Genomics for CKAP5 Gene

Regulatory Elements for CKAP5 Gene

Enhancers for CKAP5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CKAP5 on UCSC Golden Path with GeneCards custom track

Promoters for CKAP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CKAP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CKAP5 Gene

Chromosome:
11
Start:
46,743,048 bp from pter
End:
46,846,308 bp from pter
Size:
103,261 bases
Orientation:
Minus strand

Genomic View for CKAP5 Gene

Genes around CKAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP5 Gene

Proteins for CKAP5 Gene

  • Protein details for CKAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14008-CKAP5_HUMAN
    Recommended name:
    Cytoskeleton-associated protein 5
    Protein Accession:
    Q14008
    Secondary Accessions:
    • Q05D70
    • Q0VAX7
    • Q0VAX8
    • Q14668
    • Q2TA89
    • Q6NSH4

    Protein attributes for CKAP5 Gene

    Size:
    2032 amino acids
    Molecular mass:
    225495 Da
    Quaternary structure:
    • Interacts with TACC1 (PubMed:11903063). Interacts with SLAIN2 (PubMed:21646404). Interacts with HNRNPA2B1 (PubMed:15703215).
    SequenceCaution:
    • Sequence=AAH17856.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70136.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI11044.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI20871.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=BAA07892.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CKAP5 Gene

    Alternative splice isoforms for CKAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKAP5 Gene

Proteomics data for CKAP5 Gene at MOPED

Selected DME Specific Peptides for CKAP5 Gene

Post-translational modifications for CKAP5 Gene

  • Ubiquitination at Lys 48, Lys 754, Lys 1523, Lys 1774, and Lys 1981
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for CKAP5 Gene

Protein Domains for CKAP5 Gene

Suggested Antigen Peptide Sequences for CKAP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q14008

UniProtKB/Swiss-Prot:

CKAP5_HUMAN :
  • Belongs to the TOG/XMAP215 family.
  • Contains 10 HEAT repeats.
Family:
  • Belongs to the TOG/XMAP215 family.
Similarity:
  • Contains 10 HEAT repeats.
genes like me logo Genes that share domains with CKAP5: view

No data available for Gene Families for CKAP5 Gene

Function for CKAP5 Gene

Molecular function for CKAP5 Gene

UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles.

Enzyme Numbers (IUBMB) for CKAP5 Gene

genes like me logo Genes that share phenotypes with CKAP5: view

Animal Models for CKAP5 Gene

MGI Knock Outs for CKAP5:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKAP5 Gene

Localization for CKAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected on centrosomes during interphase. Detected on spindle poles and microtubules during mitosis. {ECO:0000269 PubMed:21646404}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKAP5 Gene COMPARTMENTS Subcellular localization image for CKAP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 colocalizes_with microtubule cytoskeleton ISS 15703215
genes like me logo Genes that share ontologies with CKAP5: view

Pathways & Interactions for CKAP5 Gene

genes like me logo Genes that share pathways with CKAP5: view

Pathways by source for CKAP5 Gene

Gene Ontology (GO) - Biological Process for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0050658 RNA transport ISS 15703215
genes like me logo Genes that share ontologies with CKAP5: view

No data available for SIGNOR curated interactions for CKAP5 Gene

Drugs & Compounds for CKAP5 Gene

(2) Drugs for CKAP5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10-DAB (10-Deacetylbaccatin) Pharma Precursor of antitumor compound Palitaxel and Docetaxel 0
ABT-751 (E7010) Pharma Inhibitor of microtubule polymerization,antimitotic 0

(2) ApexBio Compounds for CKAP5 Gene

Compound Action Cas Number
10-DAB (10-Deacetylbaccatin) Precursor of antitumor compound Palitaxel and Docetaxel 32981-86-5
ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic 141430-65-1
genes like me logo Genes that share compounds with CKAP5: view

Transcripts for CKAP5 Gene

Unigene Clusters for CKAP5 Gene

Cytoskeleton associated protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a ·
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:

ExUns: 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for CKAP5 Gene

GeneLoc Exon Structure for
CKAP5
ECgene alternative splicing isoforms for
CKAP5

Expression for CKAP5 Gene

mRNA expression in normal human tissues for CKAP5 Gene

Protein differential expression in normal tissues from HIPED for CKAP5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKAP5 Gene



SOURCE GeneReport for Unigene cluster for CKAP5 Gene Hs.201253

mRNA Expression by UniProt/SwissProt for CKAP5 Gene

Q14008-CKAP5_HUMAN
Tissue specificity: Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas.
genes like me logo Genes that share expression patterns with CKAP5: view

Protein tissue co-expression partners for CKAP5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CKAP5 Gene

Orthologs for CKAP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKAP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CKAP5 35
  • 92.31 (n)
  • 96.16 (a)
CKAP5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKAP5 35
  • 92.86 (n)
  • 96.65 (a)
CKAP5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ckap5 35
  • 90.52 (n)
  • 94.98 (a)
Ckap5 16
Ckap5 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CKAP5 35
  • 99.67 (n)
  • 99.8 (a)
CKAP5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ckap5 35
  • 90.37 (n)
  • 95.08 (a)
oppossum
(Monodelphis domestica)
Mammalia CKAP5 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CKAP5 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CKAP5 35
  • 80.19 (n)
  • 89.31 (a)
CKAP5 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CKAP5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap5 35
  • 73.85 (n)
  • 81.85 (a)
Str.3305 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398198 35
zebrafish
(Danio rerio)
Actinopterygii ckap5 35
  • 70.81 (n)
  • 76.94 (a)
ckap5 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011162 35
  • 50.43 (n)
  • 45.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta msps 35
  • 50.53 (n)
  • 44.02 (a)
msps 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54A3.2 36
  • 24 (a)
OneToMany
T08D2.8 36
  • 30 (a)
OneToMany
zyg-9 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STU2 36
  • 25 (a)
OneToOne
STU2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MOR1 35
  • 45.42 (n)
  • 31.99 (a)
rice
(Oryza sativa)
Liliopsida Os01g0816400 35
  • 44.79 (n)
  • 33.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2441 36
  • 44 (a)
OneToOne
Species with no ortholog for CKAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKAP5 Gene

ENSEMBL:
Gene Tree for CKAP5 (if available)
TreeFam:
Gene Tree for CKAP5 (if available)

Paralogs for CKAP5 Gene

No data available for Paralogs for CKAP5 Gene

Variants for CKAP5 Gene

Sequence variations from dbSNP and Humsavar for CKAP5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11038988 - 46,780,273(+) CAACA(C/T)ACAGA reference, missense
rs1007738 -- 46,827,809(+) GAAAC(A/G)GCATT intron-variant
rs1037872 -- 46,828,647(-) CTCAT(C/T)GTACT intron-variant
rs1037873 -- 46,828,641(-) GTACT(A/T)TGTTT intron-variant
rs1130904 -- 46,744,085(-) CCTCC(G/T)CCACA reference, missense

Variation tolerance for CKAP5 Gene

Residual Variation Intolerance Score: 1.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKAP5 Gene

HapMap Linkage Disequilibrium report
CKAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CKAP5 Gene

Disorders for CKAP5 Gene

Relevant External Links for CKAP5

Genetic Association Database (GAD)
CKAP5
Human Genome Epidemiology (HuGE) Navigator
CKAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKAP5

No disorders were found for CKAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKAP5 Gene

Publications for CKAP5 Gene

  1. Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. (PMID: 8536682) Charrasse S. … Larroque C. (Eur. J. Biochem. 1995) 2 3 4 67
  2. Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. (PMID: 18663358) De Luca M. … Guarguaglini G. (Oncogene 2008) 3 23
  3. TACC1-chTOG-Aurora A protein complex in breast cancer. (PMID: 14603251) Conte N. … Birnbaum D. (Oncogene 2003) 3 23
  4. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3

Products for CKAP5 Gene

Sources for CKAP5 Gene

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