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Aliases for CKAP5 Gene

Aliases for CKAP5 Gene

  • Cytoskeleton Associated Protein 5 2 3 5
  • Colonic And Hepatic Tumor Overexpressed Gene Protein 3 4
  • Ch-TOG 3 4
  • Colonic And Hepatic Tumor Over-Expressed Gene Protein 3
  • Cytoskeleton-Associated Protein 5 3
  • EC 3.1.1.29 61
  • EC 2.7.7.6 61
  • KIAA0097 4
  • CHTOG 3
  • MSPS 3
  • TOGp 3
  • TOG 3

External Ids for CKAP5 Gene

Previous GeneCards Identifiers for CKAP5 Gene

  • GC11M046722
  • GC11M046470
  • GC11M046815
  • GC11M048068
  • GC11M048794
  • GC11M049892
  • GC11M047086
  • GC11M047930
  • GC11M050784
  • GC11M051579

Summaries for CKAP5 Gene

Entrez Gene Summary for CKAP5 Gene

  • This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for CKAP5 Gene

CKAP5 (Cytoskeleton Associated Protein 5) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include binding and endonuclease activity.

UniProtKB/Swiss-Prot for CKAP5 Gene

  • Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).

Gene Wiki entry for CKAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP5 Gene

Genomics for CKAP5 Gene

Regulatory Elements for CKAP5 Gene

Enhancers for CKAP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F046731 0.3 FANTOM5 10.9 +114.6 114554 0.4 F2 ARHGAP1 ZNF408 SNORD67 CKAP5 PACSIN3 MDK DGKZ MIR5582
GH11F046710 0.5 Ensembl ENCODE 10.5 +135.0 135045 1.9 NR2F2 SNORD67 CKAP5 ATG13 HARBI1 C11orf49 MYBPC3 F2 ZNF408
GH11F046647 1.2 Ensembl ENCODE 10.3 +197.1 197072 2.8 CTCF NFIA JUN SIN3A RAD21 ATF2 NR2F2 JUND POLR2A ZBTB48 ATG13 ZNF408 ARHGAP1 HARBI1 F2 AMBRA1 CHRM4 SNORD67 CKAP5 LRP4
GH11F046692 0.7 ENCODE 10.3 +153.7 153663 0.2 F2 SNORD67 CKAP5 PIR37478 GC11P046676
GH11F046686 0.4 ENCODE 10.3 +158.6 158642 2.1 ZNF692 ZBTB33 ZIC2 NR2F2 F2 SNORD67 CKAP5 ACP2 PIR37478 GC11P046676
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CKAP5 on UCSC Golden Path with GeneCards custom track

Promoters for CKAP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000188581 308 2400 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF121 SLC30A9

Genomic Location for CKAP5 Gene

Chromosome:
11
Start:
46,743,048 bp from pter
End:
46,846,308 bp from pter
Size:
103,261 bases
Orientation:
Minus strand

Genomic View for CKAP5 Gene

Genes around CKAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP5 Gene

Proteins for CKAP5 Gene

  • Protein details for CKAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14008-CKAP5_HUMAN
    Recommended name:
    Cytoskeleton-associated protein 5
    Protein Accession:
    Q14008
    Secondary Accessions:
    • Q05D70
    • Q0VAX7
    • Q0VAX8
    • Q14668
    • Q2TA89
    • Q6NSH4

    Protein attributes for CKAP5 Gene

    Size:
    2032 amino acids
    Molecular mass:
    225495 Da
    Quaternary structure:
    • Interacts with TACC1 (PubMed:11903063). Interacts with SLAIN2 (PubMed:21646404). Interacts with HNRNPA2B1 (PubMed:15703215). Interacts with TACC3 independently of clathrin. Interacts with TACC3 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges (PubMed:21297582). Interacts with NDC80; indicative for an association with the NDC80 comnplex (PubMed:27156448).
    SequenceCaution:
    • Sequence=AAH17856.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70136.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI11044.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI20871.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=BAA07892.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CKAP5 Gene

    Alternative splice isoforms for CKAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKAP5 Gene

Selected DME Specific Peptides for CKAP5 Gene

Post-translational modifications for CKAP5 Gene

  • Ubiquitination at Lys 48, Lys 754, Lys 1523, Lys 1774, and Lys 1981
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CKAP5 (CKAP5)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CKAP5

Domains & Families for CKAP5 Gene

Protein Domains for CKAP5 Gene

Suggested Antigen Peptide Sequences for CKAP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q14008

UniProtKB/Swiss-Prot:

CKAP5_HUMAN :
  • The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from mictotubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice.
  • Belongs to the TOG/XMAP215 family.
  • Contains 10 HEAT repeats.
Domain:
  • The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from mictotubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice.
Family:
  • Belongs to the TOG/XMAP215 family.
Similarity:
  • Contains 10 HEAT repeats.
genes like me logo Genes that share domains with CKAP5: view

No data available for Gene Families for CKAP5 Gene

Function for CKAP5 Gene

Molecular function for CKAP5 Gene

UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).

Enzyme Numbers (IUBMB) for CKAP5 Gene

Gene Ontology (GO) - Molecular Function for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11903063
GO:0051010 microtubule plus-end binding IBA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with CKAP5: view
genes like me logo Genes that share phenotypes with CKAP5: view

Animal Models for CKAP5 Gene

MGI Knock Outs for CKAP5:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CKAP5

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKAP5 Gene

Localization for CKAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtuble plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells. {ECO:0000269 PubMed:21646404, ECO:0000269 PubMed:23251535, ECO:0000269 PubMed:25596274}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKAP5 Gene COMPARTMENTS Subcellular localization image for CKAP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 25596274
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IEA,IDA 21646404
GO:0000930 colocalizes_with gamma-tubulin complex IDA 14718566
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CKAP5: view

Pathways & Interactions for CKAP5 Gene

genes like me logo Genes that share pathways with CKAP5: view

Pathways by source for CKAP5 Gene

Gene Ontology (GO) - Biological Process for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007051 spindle organization IMP 14718566
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with CKAP5: view

No data available for SIGNOR curated interactions for CKAP5 Gene

Drugs & Compounds for CKAP5 Gene

(2) Drugs for CKAP5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10-DAB (10-Deacetylbaccatin) Pharma Precursor of antitumor compound Palitaxel and Docetaxel 0
ABT-751 (E7010) Pharma Inhibitor of microtubule polymerization,antimitotic 0

(2) ApexBio Compounds for CKAP5 Gene

Compound Action Cas Number
10-DAB (10-Deacetylbaccatin) Precursor of antitumor compound Palitaxel and Docetaxel 32981-86-5
ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic 141430-65-1
genes like me logo Genes that share compounds with CKAP5: view

Transcripts for CKAP5 Gene

Unigene Clusters for CKAP5 Gene

Cytoskeleton associated protein 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CKAP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a ·
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:

ExUns: 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for CKAP5 Gene

GeneLoc Exon Structure for
CKAP5
ECgene alternative splicing isoforms for
CKAP5

Expression for CKAP5 Gene

mRNA expression in normal human tissues for CKAP5 Gene

Protein differential expression in normal tissues from HIPED for CKAP5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CKAP5 Gene



Protein tissue co-expression partners for CKAP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CKAP5 Gene:

CKAP5

SOURCE GeneReport for Unigene cluster for CKAP5 Gene:

Hs.201253

mRNA Expression by UniProt/SwissProt for CKAP5 Gene:

Q14008-CKAP5_HUMAN
Tissue specificity: Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum.
genes like me logo Genes that share expression patterns with CKAP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CKAP5 Gene

Orthologs for CKAP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKAP5 34 35
  • 99.67 (n)
oppossum
(Monodelphis domestica)
Mammalia CKAP5 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKAP5 34 35
  • 92.86 (n)
cow
(Bos Taurus)
Mammalia CKAP5 34 35
  • 92.31 (n)
mouse
(Mus musculus)
Mammalia Ckap5 34 16 35
  • 90.52 (n)
rat
(Rattus norvegicus)
Mammalia Ckap5 34
  • 90.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CKAP5 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CKAP5 34 35
  • 80.19 (n)
lizard
(Anolis carolinensis)
Reptilia CKAP5 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap5 34
  • 73.85 (n)
Str.3305 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398198 34
zebrafish
(Danio rerio)
Actinopterygii ckap5 34 35
  • 70.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta msps 34 35
  • 50.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011162 34
  • 50.43 (n)
worm
(Caenorhabditis elegans)
Secernentea T08D2.8 35
  • 30 (a)
OneToMany
zyg-9 35
  • 26 (a)
OneToMany
F54A3.2 35
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STU2 35 37
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MOR1 34
  • 45.42 (n)
rice
(Oryza sativa)
Liliopsida Os01g0816400 34
  • 44.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2441 35
  • 44 (a)
OneToOne
Species where no ortholog for CKAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKAP5 Gene

ENSEMBL:
Gene Tree for CKAP5 (if available)
TreeFam:
Gene Tree for CKAP5 (if available)

Paralogs for CKAP5 Gene

No data available for Paralogs for CKAP5 Gene

Variants for CKAP5 Gene

Sequence variations from dbSNP and Humsavar for CKAP5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs193921076 Uncertain significance 46,809,784(-) AAGCT(A/C/G)AATTG reference, missense
rs1007738 -- 46,827,809(+) GAAAC(A/G)GCATT intron-variant
rs1037872 -- 46,828,647(-) CTCAT(C/T)GTACT intron-variant
rs1037873 -- 46,828,641(-) GTACT(A/G)TGTTT intron-variant
rs10466476 -- 46,760,168(+) AAGTG(A/T)ATCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CKAP5 Gene

Variant ID Type Subtype PubMed ID
esv3547703 CNV deletion 23714750
nsv1122612 CNV deletion 24896259
nsv1138017 CNV deletion 24896259
nsv472167 CNV novel sequence insertion 20440878

Variation tolerance for CKAP5 Gene

Residual Variation Intolerance Score: 1.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP5 Gene

Disorders for CKAP5 Gene

Relevant External Links for CKAP5

Genetic Association Database (GAD)
CKAP5
Human Genome Epidemiology (HuGE) Navigator
CKAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKAP5

No disorders were found for CKAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKAP5 Gene

Publications for CKAP5 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  2. Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. (PMID: 8536682) Charrasse S. … Larroque C. (Eur. J. Biochem. 1995) 2 3 4 64
  3. TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation. (PMID: 25596274) Gutierrez-Caballero C. … Royle S.J. (Biol. Open 2015) 3 4 64
  4. Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. (PMID: 23251535) Nakamura S. … Mimori-Kiyosue Y. (PLoS ONE 2012) 3 4 64
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64

Products for CKAP5 Gene

Sources for CKAP5 Gene

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