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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKAP5 Gene

protein-coding   GIFtS: 61
GCID: GC11M048794

Cytoskeleton Associated Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytoskeleton Associated Protein 51 2     ch-TOG2
Colonic And Hepatic Tumor Overexpressed Gene Protein2 3     Colonic And Hepatic Tumor Over-Expressed Gene Protein2
CHTOG2 5     Cytoskeleton-Associated Protein 52
MSPS2 5     Ch-TOG3
KIAA00973 5     EC 2.7.7.68
TOG2     EC 3.1.1.298
TOGp2     

External Ids:    HGNC: 289591   Entrez Gene: 97932   Ensembl: ENSG000001752167   OMIM: 6111425   UniProtKB: Q140083   

Export aliases for CKAP5 gene to outside databases

Previous GC identifers: GC11M046722 GC11M046470 GC11M046815 GC11M048068


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKAP5 Gene:
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half
of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding
tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules
from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be
necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also
plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear
ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, Aug 2011)

GeneCards Summary for CKAP5 Gene: 
CKAP5 (cytoskeleton associated protein 5) is a protein-coding gene. Diseases associated with CKAP5 include acrocephalosyndactylia, and hepatitis, and among its related super-pathways are G2/M Transition and Mitotic Anaphase. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CKAP5_HUMAN, Q14008
Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization.
Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles

Gene Wiki entry for CKAP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKAP5 gene promoter:
         NF-1   AML1a   Lmo2   CUTL1   HEN1   Egr-2   E2F-1   E2F   Zic3   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CKAP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKAP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

CKAP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M048794:  view genomic region     (about GC identifiers)

Start:
46,764,598 bp from pter      End:
46,867,847 bp from pter
Size:
103,250 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CKAP5_HUMAN, Q14008 (See protein sequence)
Recommended Name: Cytoskeleton-associated protein 5  
Size: 2032 amino acids; 225495 Da
Subunit: Interacts with TACC1. Interacts with SLAIN2
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
spindle pole. Note=Detected on centrosomes during interphase. Detected on spindle poles and microtubules during
mitosis
Sequence caution: Sequence=AAH17856.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH70136.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI11044.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI20871.1; Type=Frameshift; Positions=18; Sequence=BAA07892.2; Type=Erroneous
initiation;
Secondary accessions: Q05D70 Q0VAX7 Q0VAX8 Q14668 Q2TA89 Q6NSH4
Alternative splicing: 3 isoforms:  Q14008-1   Q14008-2   Q14008-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CKAP5: NX_Q14008

Explore proteomics data for CKAP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14008

  • 2 DME Specific Peptides for CKAP5 (Q14008)
     KKIGSKE  KIILLKP 

    CKAP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CKAP5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001008938.1  NP_055571.2  

    ENSEMBL proteins: 
     ENSP00000432768   ENSP00000346566   ENSP00000434523   ENSP00000431509   ENSP00000436052  
     ENSP00000436769   ENSP00000395302   ENSP00000310227  
    Reactome Protein details: Q14008
    Human Recombinant Protein Products for CKAP5: 
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    Cloud-Clone Corp. Proteins for CKAP5 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0000930colocalizes with gamma-tubulin complex IDA14718566
    GO:0005813centrosome IDA14718566
    GO:0005829cytosol TAS--
    GO:0015630colocalizes with microtubule cytoskeleton ISS15703215

    CKAP5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR000357 HEAT
     IPR024395 CLASP_N_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q14008

    ProtoNet protein and cluster: Q14008

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: CKAP5_HUMAN, Q14008
    Similarity: Belongs to the TOG/XMAP215 family
    Similarity: Contains 10 HEAT repeats


    CKAP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CKAP5_HUMAN, Q14008
    Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization.
    Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles

         Enzyme Numbers (IUBMB): EC 2.7.7.62 EC 3.1.1.292

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004519endonuclease activity ----
    GO:0005488binding ----
    GO:0005515protein binding IPI11903063
         
    CKAP5 for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for CKAP5:
     Cell cycle / mitosis defect  Cell division defect  Decreased Hepatitis C virus re  Decreased cell number, increas 
     Decreased homologous recombina  Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Increased number of cells in m 
     Increased number of mitotic ce  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ckap5):
     craniofacial  digestive/alimentary  growth/size 

    CKAP5 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCKAP5 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CKAP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Aurora A signaling
    Aurora A signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CKAP5
        Aurora A signaling

    5/15        Reactome Pathways for CKAP5 (see all 15)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Centrosome maturation
    Mitotic Anaphase



    CKAP5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CKAP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/911 Interacting proteins for CKAP5 (Q140081, 2, 3 ENSP000003465664) via UniProtKB, MINT, STRING, and/or I2D (see all 911)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TACC3Q9Y6A52, 3, ENSP000003265504MINT-8145000 MINT-8144928 MINT-8144977 MINT-8145261 MINT-8145016 MINT-8145273 I2D: score=3 STRING: ENSP00000326550
    SNW1Q135732, 3, ENSP000002615314MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000261531
    NCK1P163331, 3, ENSP000002889864EBI-310585,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    CDK9P507502, 3, ENSP000003623614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000362361
    CLTAP094962, ENSP000002422854MINT-8144928 MINT-8145261 MINT-8145273 STRING: ENSP00000242285
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007051spindle organization IMP14718566
    GO:0007067mitosis IEA--
    GO:0030951establishment or maintenance of microtubule cytoskeleton polarity IMP14718566

    CKAP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKAP5

    Search CenterWatch for drugs/clinical trials and news about CKAP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CKAP5 gene (2 alternative transcripts): 
    NM_001008938.3  NM_014756.3  

    Unigene Cluster for CKAP5:

    Cytoskeleton associated protein 5
    Hs.201253  [show with all ESTs]
    Unigene Representative Sequence: NM_001008938
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529230(uc001ndh.1) ENST00000354558 ENST00000533413 ENST00000525896
    ENST00000527333 ENST00000526876 ENST00000526943 ENST00000528593 ENST00000532321
    ENST00000526496 ENST00000525248 ENST00000415402(uc009ylg.1 uc001ndi.2)
    ENST00000312055(uc001ndj.2)
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    Additional mRNA sequence: 

    BC017856.1 BC035554.1 BC070136.1 BC111043.1 BC120869.1 BC120870.1 D43948.1 X92474.1 

    17 DOTS entries:

    DT.218700  DT.92326973  DT.95371188  DT.120702319  DT.120702300  DT.95360204  DT.100818315  DT.100687634 
    DT.120702250  DT.95371190  DT.75141786  DT.100725564  DT.40116371  DT.40132583  DT.91755028  DT.95194757 
    DT.95202523 

    24/401 AceView cDNA sequences (see all 401):

    BQ232493 AI675694 BP362212 AU133351 BX117298 CD108137 BM801727 BC035554 
    BG286236 BU521217 BC070136 BM564606 BF437824 BE728125 BE276294 AU130801 
    BU661430 AA330998 AV654973 AI017802 BU517318 BM450155 BM458468 AU126029 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CKAP5 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                            -               

    ExUns: 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for CKAP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKAP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACAACTAA
    CKAP5 Expression
    About this image


    See CKAP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKAP5

    SOURCE GeneReport for Unigene cluster: Hs.201253

    UniProtKB/Swiss-Prot: CKAP5_HUMAN, Q14008
    Tissue specificity: Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain,
    heart, placenta, lung, liver, kidney and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CKAP5 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckap51 , 5 cytoskeleton associated protein 51, 5 90.52(n)1
    94.98(a)1
      2 (50.63 cM)5
    757861  NM_001165989.11  NP_001159461.11 
     915267625 
    chicken
    (Gallus gallus)
    Aves CKAP51 cytoskeleton associated protein 5 80.22(n)
    89.55(a)
      423190  NM_001199646.1  NP_001186575.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    CKAP56
    Uncharacterized protein
    87(a)
    49(a)
    possible ortholog
    possible ortholog
    1(43165521-43247418)
    AAWZ02036470(13609-15870)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981982 microtubule associated protein XMAP215 isoform M 77.77(n)    AF274063.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ckap51 cytoskeleton associated protein 5 70.79(n)
    77.04(a)
      492614  NM_001037667.2  NP_001032756.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta msps1 mini spindles 50.22(n)
    43.66(a)
      41952  NM_169698.2  NP_732105.2 
    worm
    (Caenorhabditis elegans)
    Secernentea zyg-91 Protein ZYG-9 41.71(n)
    27.8(a)
      174350  NM_063383.3  NP_495784.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STU2(YLR045C)4 Microtubule-associated protein (MAP) of the XMAP215/Dis1 more   --   12(237703-235037) 850734  NP_013146.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MOR11 microtubule organization 1 protein 44.63(n)
    31(a)
      818131  NM_129117.4  NP_565811.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g08164001 hypothetical protein 43.03(n)
    31.37(a)
      4327486  NM_001051153.1  NP_001044618.1 


    ENSEMBL Gene Tree for CKAP5 (if available)
    TreeFam Gene Tree for CKAP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1980 SNPs in CKAP5 are shown (see all 1980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004642891,2
    C,Funtested146725537(+) ATAATA/CCCTGC 4 G syn11Minor allele frequency- C:0.01EU 475
    rs1939210761,2
    Cuntested146757083(-) AAGCTA/C/GAATTG 4 K E mis10--------
    rs751427941,2
    C--46503163(+) TTGCA-/GGGGAC 2 -- int10--------
    rs757475511,2
    C--46504333(+) AATTAA/TATTAA 2 -- int10--------
    rs675664521,2
    C--46504335(+) TTATA-/ATTAA 
            
    TTAAA
    2 -- int10--------
    rs1121087511,2
    C--46508927(+) ACTCTC/TCTCAA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs665221721,2
    C--46511099(+) TAATG-/TTTTTT 2 -- int11Minor allele frequency- T:0.00NA 2
    rs1414136371,2
    C--46519705(+) CAAAT-/CC    
       T
    /CTC
    CTACT
    4 -- cds10--------
    rs114411291,2
    C--46521478(+) TTTTTT/-GACAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs359286391,2
    C--46522007(+) TTTCC-/AAGAAGAA 4 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for CKAP5 (46764598 - 46867847 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CKAP5: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CKAP5
    DNA2.0 Custom Variant and Variant Library Synthesis for CKAP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611142    OMIM disorders: --

    8 diseases for CKAP5:    About MalaCards
    acrocephalosyndactylia    hepatitis    cerebrovascular accident    lactic acidosis
    sudden infant death syndrome    macular degeneration    ataxia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CKAP5:
    Sudden infant death syndrome

    CKAP5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CKAP5
    Human Genome Epidemiology (HuGE) Navigator: CKAP5 (2 documents)

    Export disorders for CKAP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CKAP5 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with CKAP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. (PubMed id 8536682)1, 2, 3 Charrasse S.... Larroque C. (1995)
    2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    4. New sequence variants associated with bone mineral density. (PubMed id 19079262)1, 4 Styrkarsdottir U....Stefansson K. (2009)
    5. The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. (PubMed id 12569123)1, 2 Gergely F.... Raff J.W. (2003)
    6. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PubMed id 11903063)1, 2 Lauffart B.... Still I.H. (2002)
    7. Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. (PubMed id 18663358)1, 9 De Luca M....Guarguaglini G. (2008)
    8. TACC1-chTOG-Aurora A protein complex in breast cancer. (PubMed id 14603251)1, 9 Conte N.... Birnbaum D. (2003)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. An N-terminal SIAH-interacting motif regulates the sta bility of the ubiquitin specific protease (USP)-19. (PubMed id 23500468)1 Velasco K....Lindsten K. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9793 HGNC: 28959 AceView: ch-TOG Ensembl:ENSG00000175216 euGenes: HUgn9793
    ECgene: CKAP5 H-InvDB: CKAP5

    (According to HUGE)
    About This Section
    HUGE: KIAA0097

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CKAP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CKAP5 gene:
    Search GeneIP for patents involving CKAP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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