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Aliases for CKAP5 Gene

Aliases for CKAP5 Gene

  • Cytoskeleton Associated Protein 5 2 3
  • Colonic And Hepatic Tumor Overexpressed Gene Protein 3 4
  • KIAA0097 4 6
  • Ch-TOG 3 4
  • CHTOG 3 6
  • MSPS 3 6
  • Colonic And Hepatic Tumor Over-Expressed Gene Protein 3
  • Cytoskeleton-Associated Protein 5 3
  • EC 3.1.1.29 63
  • EC 2.7.7.6 63
  • TOGp 3
  • TOG 3

External Ids for CKAP5 Gene

Previous GeneCards Identifiers for CKAP5 Gene

  • GC11M046722
  • GC11M046470
  • GC11M046815
  • GC11M048068
  • GC11M048794
  • GC11M049892

Summaries for CKAP5 Gene

Entrez Gene Summary for CKAP5 Gene

  • This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for CKAP5 Gene

CKAP5 (Cytoskeleton Associated Protein 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CKAP5 Gene

  • Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles.

Gene Wiki entry for CKAP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP5 Gene

Genomics for CKAP5 Gene

Regulatory Elements for CKAP5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CKAP5 Gene

Start:
46,743,048 bp from pter
End:
46,846,308 bp from pter
Size:
103,261 bases
Orientation:
Minus strand

Genomic View for CKAP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP5 Gene

Proteins for CKAP5 Gene

  • Protein details for CKAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14008-CKAP5_HUMAN
    Recommended name:
    Cytoskeleton-associated protein 5
    Protein Accession:
    Q14008
    Secondary Accessions:
    • Q05D70
    • Q0VAX7
    • Q0VAX8
    • Q14668
    • Q2TA89
    • Q6NSH4

    Protein attributes for CKAP5 Gene

    Size:
    2032 amino acids
    Molecular mass:
    225495 Da
    Quaternary structure:
    • Interacts with TACC1. Interacts with SLAIN2.
    SequenceCaution:
    • Sequence=AAH17856.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70136.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI11044.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI20871.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=BAA07892.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CKAP5 Gene

    Alternative splice isoforms for CKAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKAP5 Gene

Proteomics data for CKAP5 Gene at MOPED

Selected DME Specific Peptides for CKAP5 Gene

Post-translational modifications for CKAP5 Gene

  • Ubiquitination at Lys48, Lys754, Lys1523, Lys1774, and Lys1981
  • Modification sites at PhosphoSitePlus

Other Protein References for CKAP5 Gene

Domains for CKAP5 Gene

Protein Domains for CKAP5 Gene

Suggested Antigen Peptide Sequences for CKAP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q14008

UniProtKB/Swiss-Prot:

CKAP5_HUMAN :
  • Q14008
Family:
  • Belongs to the TOG/XMAP215 family.
Similarity:
  • Contains 10 HEAT repeats.
genes like me logo Genes that share domains with CKAP5: view

No data available for Gene Families for CKAP5 Gene

Function for CKAP5 Gene

Molecular function for CKAP5 Gene

UniProtKB/Swiss-Prot Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles.

Enzyme Numbers (IUBMB) for CKAP5 Gene

Gene Ontology (GO) - Molecular Function for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity --
GO:0005488 binding --
GO:0005515 protein binding IPI 11903063
genes like me logo Genes that share ontologies with CKAP5: view
genes like me logo Genes that share phenotypes with CKAP5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKAP5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CKAP5 Gene

Localization for CKAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected on centrosomes during interphase. Detected on spindle poles and microtubules during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKAP5 Gene COMPARTMENTS Subcellular localization image for CKAP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21646404
GO:0000930 colocalizes_with gamma-tubulin complex IDA 14718566
GO:0005813 centrosome IDA 14718566
GO:0005829 cytosol TAS --
GO:0015630 colocalizes_with microtubule cytoskeleton ISS 15703215
genes like me logo Genes that share ontologies with CKAP5: view

Pathways for CKAP5 Gene

genes like me logo Genes that share pathways with CKAP5: view

Pathways by source for CKAP5 Gene

Gene Ontology (GO) - Biological Process for CKAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007051 spindle organization IMP 14718566
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with CKAP5: view

Transcripts for CKAP5 Gene

Unigene Clusters for CKAP5 Gene

Cytoskeleton associated protein 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKAP5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CKAP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a ·
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:

ExUns: 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for CKAP5 Gene

GeneLoc Exon Structure for
CKAP5
ECgene alternative splicing isoforms for
CKAP5

Expression for CKAP5 Gene

mRNA expression in normal human tissues for CKAP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKAP5 Gene

SOURCE GeneReport for Unigene cluster for CKAP5 Gene Hs.201253

mRNA Expression by UniProt/SwissProt for CKAP5 Gene

Q14008-CKAP5_HUMAN
Tissue specificity: Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas
genes like me logo Genes that share expressions with CKAP5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CKAP5 Gene

Orthologs for CKAP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKAP5 35
  • 99.67 (n)
  • 99.8 (a)
CKAP5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CKAP5 35
  • 92.31 (n)
  • 96.16 (a)
CKAP5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKAP5 35
  • 92.86 (n)
  • 96.65 (a)
CKAP5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ckap5 35
  • 90.52 (n)
  • 94.98 (a)
Ckap5 16
Ckap5 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CKAP5 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CKAP5 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ckap5 35
  • 90.37 (n)
  • 95.08 (a)
chicken
(Gallus gallus)
Aves CKAP5 35
  • 80.19 (n)
  • 89.31 (a)
CKAP5 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CKAP5 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398198 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap5 35
  • 73.85 (n)
  • 81.85 (a)
Str.3305 35
zebrafish
(Danio rerio)
Actinopterygii ckap5 35
  • 70.81 (n)
  • 76.94 (a)
ckap5 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011162 35
  • 50.43 (n)
  • 45.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta msps 35
  • 50.53 (n)
  • 44.02 (a)
msps 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54A3.2 36
  • 24 (a)
OneToMany
T08D2.8 36
  • 30 (a)
OneToMany
zyg-9 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STU2 36
  • 25 (a)
OneToOne
STU2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MOR1 35
  • 45.42 (n)
  • 31.99 (a)
rice
(Oryza sativa)
Liliopsida Os01g0816400 35
  • 44.79 (n)
  • 33.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2441 36
  • 44 (a)
OneToOne
Species with no ortholog for CKAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKAP5 Gene

ENSEMBL:
Gene Tree for CKAP5 (if available)
TreeFam:
Gene Tree for CKAP5 (if available)

Paralogs for CKAP5 Gene

No data available for Paralogs for CKAP5 Gene

Variants for CKAP5 Gene

Sequence variations from dbSNP and Humsavar for CKAP5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs721436 -- 46,832,767(-) ATTTA(A/T)TCTTT intron-variant
rs1007738 -- 46,827,809(+) GAAAC(A/G)GCATT intron-variant
rs1037872 -- 46,828,647(-) CTCAT(C/T)GTACT intron-variant
rs1037873 -- 46,828,641(-) GTACT(A/T)TGTTT intron-variant
rs1130904 -- 46,744,085(-) CCTCC(G/T)CCACA missense, reference

Relevant External Links for CKAP5 Gene

HapMap Linkage Disequilibrium report
CKAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CKAP5 Gene

Disorders for CKAP5 Gene

(1) University of Copenhagen DISEASES for CKAP5 Gene

Relevant External Links for CKAP5

Genetic Association Database (GAD)
CKAP5
Human Genome Epidemiology (HuGE) Navigator
CKAP5
genes like me logo Genes that share disorders with CKAP5: view

No data available for UniProtKB/Swiss-Prot for CKAP5 Gene

Publications for CKAP5 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. (PMID: 8536682) Charrasse S. … Larroque C. (Eur. J. Biochem. 1995) 2 3 4
  3. TACC1-chTOG-Aurora A protein complex in breast cancer. (PMID: 14603251) Conte N. … Birnbaum D. (Oncogene 2003) 3 23
  4. The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. (PMID: 12569123) Gergely F. … Raff J.W. (Genes Dev. 2003) 3 4
  5. New sequence variants associated with bone mineral density. (PMID: 19079262) Styrkarsdottir U. … Stefansson K. (Nat. Genet. 2009) 3 48

Products for CKAP5 Gene

  • Addgene plasmids for CKAP5

Sources for CKAP5 Gene

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