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Aliases for CKAP4 Gene

Aliases for CKAP4 Gene

  • Cytoskeleton-Associated Protein 4 2 3 5
  • 63-KDa Cytoskeleton-Linking Membrane Protein 3 4
  • CLIMP-63 3 4
  • P63 3 4
  • Transmembrane Protein (63kD), Endoplasmic Reticulum/Golgi Intermediate Compartment 3
  • Type-II Transmembrane Protein P63 3
  • 63 KDa Membrane Protein 3
  • ERGIC-63 3

External Ids for CKAP4 Gene

Previous GeneCards Identifiers for CKAP4 Gene

  • GC12M105742
  • GC12M106512
  • GC12M105134
  • GC12M106631
  • GC12M103692

Summaries for CKAP4 Gene

GeneCards Summary for CKAP4 Gene

CKAP4 (Cytoskeleton-Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include Exstrophy-Epispadias Complex and Interstitial Cystitis. Among its related pathways are Surfactant metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and signal transducer activity.

UniProtKB/Swiss-Prot for CKAP4 Gene

  • High-affinity epithelial cell surface receptor for APF.

  • Mediates the anchoring of the endoplasmic reticulum to microtubules.

Gene Wiki entry for CKAP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP4 Gene

Genomics for CKAP4 Gene

Regulatory Elements for CKAP4 Gene

Enhancers for CKAP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CKAP4 on UCSC Golden Path with GeneCards custom track

Promoters for CKAP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CKAP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CKAP4 Gene

106,237,877 bp from pter
106,304,279 bp from pter
66,403 bases
Minus strand

Genomic View for CKAP4 Gene

Genes around CKAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP4 Gene

Proteins for CKAP4 Gene

  • Protein details for CKAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoskeleton-associated protein 4
    Protein Accession:
    Secondary Accessions:
    • Q504S5
    • Q53ES6

    Protein attributes for CKAP4 Gene

    602 amino acids
    Molecular mass:
    66022 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH94824.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for CKAP4 Gene

Proteomics data for CKAP4 Gene at MOPED

Post-translational modifications for CKAP4 Gene

  • Increased phosphorylation during mitosis prevents binding to microtubules.
  • Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.
  • Ubiquitination at Lys 213, Lys 355, and Lys 551
  • Glycosylation at Thr 512
  • Modification sites at PhosphoSitePlus

Other Protein References for CKAP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CKAP4

No data available for DME Specific Peptides for CKAP4 Gene

Domains & Families for CKAP4 Gene

Protein Domains for CKAP4 Gene


Suggested Antigen Peptide Sequences for CKAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CKAP4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CKAP4 Gene

Function for CKAP4 Gene

Molecular function for CKAP4 Gene

UniProtKB/Swiss-Prot Function:
High-affinity epithelial cell surface receptor for APF.
UniProtKB/Swiss-Prot Function:
Mediates the anchoring of the endoplasmic reticulum to microtubules.
genes like me logo Genes that share phenotypes with CKAP4: view

Animal Models for CKAP4 Gene

MGI Knock Outs for CKAP4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKAP4 Gene

Localization for CKAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP4 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.

Subcellular locations from

Jensen Localization Image for CKAP4 Gene COMPARTMENTS Subcellular localization image for CKAP4 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
nucleus 4
cytosol 3
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 19401338
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane TAS 8314870
GO:0016021 integral component of membrane IEA --
GO:0042599 lamellar body TAS --
genes like me logo Genes that share ontologies with CKAP4: view

Pathways & Interactions for CKAP4 Gene

genes like me logo Genes that share pathways with CKAP4: view

Pathways by source for CKAP4 Gene

2 Reactome pathways for CKAP4 Gene
1 KEGG pathway for CKAP4 Gene

Gene Ontology (GO) - Biological Process for CKAP4 Gene


No data available for SIGNOR curated interactions for CKAP4 Gene

Drugs & Compounds for CKAP4 Gene

(2) Drugs for CKAP4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10-DAB (10-Deacetylbaccatin) Pharma Precursor of antitumor compound Palitaxel and Docetaxel 0
ABT-751 (E7010) Pharma Inhibitor of microtubule polymerization,antimitotic 0

(2) ApexBio Compounds for CKAP4 Gene

Compound Action Cas Number
10-DAB (10-Deacetylbaccatin) Precursor of antitumor compound Palitaxel and Docetaxel 32981-86-5
ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic 141430-65-1
genes like me logo Genes that share compounds with CKAP4: view

Transcripts for CKAP4 Gene

mRNA/cDNA for CKAP4 Gene

Unigene Clusters for CKAP4 Gene

Cytoskeleton-associated protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP4 Gene

No ASD Table

Relevant External Links for CKAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CKAP4 Gene

mRNA expression in normal human tissues for CKAP4 Gene

mRNA differential expression in normal tissues according to GTEx for CKAP4 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for CKAP4 Gene

This gene is overexpressed in Nasal epithelium (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKAP4 Gene

SOURCE GeneReport for Unigene cluster for CKAP4 Gene Hs.74368

genes like me logo Genes that share expression patterns with CKAP4: view

Protein tissue co-expression partners for CKAP4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CKAP4 Gene

Orthologs for CKAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CKAP4 35
  • 83.5 (n)
  • 81.97 (a)
CKAP4 36
  • 81 (a)
(Canis familiaris)
Mammalia CKAP4 35
  • 86.03 (n)
  • 82.49 (a)
CKAP4 36
  • 82 (a)
(Mus musculus)
Mammalia Ckap4 35
  • 84.21 (n)
  • 83.67 (a)
Ckap4 16
Ckap4 36
  • 83 (a)
(Pan troglodytes)
Mammalia CKAP4 35
  • 99.2 (n)
  • 99.2 (a)
CKAP4 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ckap4 35
  • 81.07 (n)
  • 78.7 (a)
(Monodelphis domestica)
Mammalia CKAP4 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CKAP4 36
  • 71 (a)
(Gallus gallus)
Aves CKAP4 35
  • 61.95 (n)
  • 57.51 (a)
CKAP4 36
  • 56 (a)
(Anolis carolinensis)
Reptilia CKAP4 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap4 35
  • 47.54 (n)
  • 33.68 (a)
Species with no ortholog for CKAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKAP4 Gene

Gene Tree for CKAP4 (if available)
Gene Tree for CKAP4 (if available)

Paralogs for CKAP4 Gene Pseudogenes for CKAP4 Gene

genes like me logo Genes that share paralogs with CKAP4: view

No data available for Paralogs for CKAP4 Gene

Variants for CKAP4 Gene

Sequence variations from dbSNP and Humsavar for CKAP4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3088113 - 106,239,791(-) GGCTC(A/C/G/T)CCCTG reference, missense
rs7112 -- 106,238,353(-) TACAC(C/G)CAGCA utr-variant-3-prime
rs10574 -- 106,238,261(-) CAGAA(A/G)GGGGA utr-variant-3-prime
rs15040 -- 106,238,787(-) TAACA(G/T)GTGGC utr-variant-3-prime
rs12818106 -- 106,239,939(+) GCTGA(A/G)GTCTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CKAP4 Gene

Variant ID Type Subtype PubMed ID
esv25104 CNV Loss 19812545

Variation tolerance for CKAP4 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CKAP4 Gene

Disorders for CKAP4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CKAP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exstrophy-epispadias complex
  • beec
interstitial cystitis
  • trigonitis
  • infective cystitis
split foot
- elite association - COSMIC cancer census association via MalaCards
Search CKAP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CKAP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CKAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKAP4 Gene

Publications for CKAP4 Gene

  1. A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PMID: 8314870) Schweizer A. … Hauri H.-P. (J. Cell Sci. 1993) 2 3 4 67
  2. Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PMID: 19144824) Planey S.L. … Zacharias D.A. (Mol. Biol. Cell 2009) 3 23
  3. Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PMID: 15703217) Vedrenne C. … Hauri H.P. (Mol. Biol. Cell 2005) 3 23
  4. Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4). (PMID: 12913003) Razzaq T.M. … Ellis V. (J. Biol. Chem. 2003) 3 23
  5. Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. (PMID: 11402071) Klopfenstein D.R. … Hauri H.P. (J. Cell Biol. 2001) 3 23

Products for CKAP4 Gene

Sources for CKAP4 Gene