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Aliases for CKAP4 Gene

Aliases for CKAP4 Gene

  • Cytoskeleton-Associated Protein 4 2 3
  • 63-KDa Cytoskeleton-Linking Membrane Protein 3 4
  • CLIMP-63 3 4
  • P63 3 4
  • Transmembrane Protein (63kD), Endoplasmic Reticulum/Golgi Intermediate Compartment 3
  • Type-II Transmembrane Protein P63 3
  • 63 KDa Membrane Protein 3
  • ERGIC-63 3

External Ids for CKAP4 Gene

Previous GeneCards Identifiers for CKAP4 Gene

  • GC12M105742
  • GC12M106512
  • GC12M105134
  • GC12M106631
  • GC12M103692

Summaries for CKAP4 Gene

GeneCards Summary for CKAP4 Gene

CKAP4 (Cytoskeleton-Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include steroid-induced glaucoma and split foot. Among its related pathways are Protein processing in endoplasmic reticulum.

UniProtKB/Swiss-Prot for CKAP4 Gene

  • High-affinity epithelial cell surface receptor for APF

  • Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Wiki entry for CKAP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP4 Gene

Genomics for CKAP4 Gene

Regulatory Elements for CKAP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CKAP4 Gene

Start:
106,237,877 bp from pter
End:
106,304,279 bp from pter
Size:
66,403 bases
Orientation:
Minus strand

Genomic View for CKAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP4 Gene

Proteins for CKAP4 Gene

  • Protein details for CKAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07065-CKAP4_HUMAN
    Recommended name:
    Cytoskeleton-associated protein 4
    Protein Accession:
    Q07065
    Secondary Accessions:
    • Q504S5
    • Q53ES6

    Protein attributes for CKAP4 Gene

    Size:
    602 amino acids
    Molecular mass:
    66022 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH94824.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for CKAP4 Gene

Proteomics data for CKAP4 Gene at MOPED

Post-translational modifications for CKAP4 Gene

  • Increased phosphorylation during mitosis prevents binding to microtubules.
  • Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.
  • Ubiquitination at Lys213, Lys355, and Lys551
  • Glycosylation at Thr512
  • Modification sites at PhosphoSitePlus

Other Protein References for CKAP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CKAP4 Gene

Domains for CKAP4 Gene

Protein Domains for CKAP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CKAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CKAP4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CKAP4 Gene

Function for CKAP4 Gene

Molecular function for CKAP4 Gene

UniProtKB/Swiss-Prot Function: High-affinity epithelial cell surface receptor for APF
UniProtKB/Swiss-Prot Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Ontology (GO) - Molecular Function for CKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0004871 signal transducer activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CKAP4: view

Phenotypes for CKAP4 Gene

GenomeRNAi human phenotypes for CKAP4:
genes like me logo Genes that share phenotypes with CKAP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKAP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CKAP4 Gene

Localization for CKAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP4 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKAP4 Gene COMPARTMENTS Subcellular localization image for CKAP4 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
plasma membrane 5
nucleus 2
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 19401338
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005811 lipid particle IDA 14741744
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CKAP4: view

Pathways for CKAP4 Gene

genes like me logo Genes that share pathways with CKAP4: view

Pathways by source for CKAP4 Gene

1 KEGG pathway for CKAP4 Gene

Gene Ontology (GO) - Biological Process for CKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0007165 signal transduction --
GO:0032784 regulation of DNA-templated transcription, elongation --
genes like me logo Genes that share ontologies with CKAP4: view

Transcripts for CKAP4 Gene

mRNA/cDNA for CKAP4 Gene

Unigene Clusters for CKAP4 Gene

Cytoskeleton-associated protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKAP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP4 Gene

No ASD Table

Relevant External Links for CKAP4 Gene

GeneLoc Exon Structure for
CKAP4
ECgene alternative splicing isoforms for
CKAP4

Expression for CKAP4 Gene

mRNA expression in normal human tissues for CKAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKAP4 Gene

This gene is overexpressed in Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKAP4 Gene

SOURCE GeneReport for Unigene cluster for CKAP4 Gene Hs.74368

genes like me logo Genes that share expressions with CKAP4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CKAP4 Gene

Orthologs for CKAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKAP4 35
  • 99.2 (n)
  • 99.2 (a)
CKAP4 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CKAP4 35
  • 83.5 (n)
  • 81.97 (a)
CKAP4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKAP4 35
  • 86.03 (n)
  • 82.49 (a)
CKAP4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ckap4 35
  • 84.21 (n)
  • 83.67 (a)
Ckap4 16
Ckap4 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CKAP4 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CKAP4 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ckap4 35
  • 81.07 (n)
  • 78.7 (a)
chicken
(Gallus gallus)
Aves CKAP4 35
  • 61.95 (n)
  • 57.51 (a)
CKAP4 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CKAP4 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap4 35
  • 47.54 (n)
  • 33.68 (a)
Species with no ortholog for CKAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKAP4 Gene

ENSEMBL:
Gene Tree for CKAP4 (if available)
TreeFam:
Gene Tree for CKAP4 (if available)

Paralogs for CKAP4 Gene

Pseudogenes.org Pseudogenes for CKAP4 Gene

genes like me logo Genes that share paralogs with CKAP4: view

No data available for Paralogs for CKAP4 Gene

Variants for CKAP4 Gene

Sequence variations from dbSNP and Humsavar for CKAP4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7112 -- 106,238,353(-) TACAC(C/G)CAGCA utr-variant-3-prime
rs10574 -- 106,238,261(-) CAGAA(A/G)GGGGA utr-variant-3-prime
rs15040 -- 106,238,787(-) TAACA(G/T)GTGGC utr-variant-3-prime
rs1049373 -- 106,238,145(-) ATGAA(A/G)AGGTT utr-variant-3-prime
rs1049385 -- 106,238,063(-) TCCCT(C/T)TGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CKAP4 Gene

Variant ID Type Subtype PubMed ID
esv25104 CNV Loss 19812545

Relevant External Links for CKAP4 Gene

HapMap Linkage Disequilibrium report
CKAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP4 Gene

Disorders for CKAP4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CKAP4 Gene including...

Search for CKAP4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CKAP4 Gene

genes like me logo Genes that share disorders with CKAP4: view

No data available for UniProtKB/Swiss-Prot for CKAP4 Gene

Publications for CKAP4 Gene

  1. Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PMID: 19144824) Planey S.L. … Zacharias D.A. (Mol. Biol. Cell 2009) 3 4 23
  2. A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PMID: 8314870) Schweizer A. … Hauri H.-P. (J. Cell Sci. 1993) 2 3 4
  3. Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PMID: 15703217) Vedrenne C. … Hauri H.P. (Mol. Biol. Cell 2005) 3 4 23
  4. Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. (PMID: 17567679) Nikonov A.V. … Kreibich G. (J. Cell Sci. 2007) 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CKAP4 Gene

Sources for CKAP4 Gene

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