Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

CKAP4 Gene

protein-coding GIFtS: 58
GCID: GC12M106631

Cytoskeleton-Associated Protein 4

See CKAP4-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytoskeleton-Associated Protein 4¹ ²		ERGIC-63²
63-KDa Cytoskeleton-Linking Membrane Protein² ³		Transmembrane Protein (63kD), Endoplasmic Reticulum/Golgi Intermediate Compartment²
p63² ³		Type-II Transmembrane Protein P63²
63 KDa Membrane Protein²		Climp-63³
CLIMP-63²

External Ids:	HGNC: 16991¹	Entrez Gene: 10970²	Ensembl: ENSG00000136026⁷	UniProtKB: Q07065³

Export aliases for CKAP4 gene to outside databases

Previous GC identifers: GC12M105742 GC12M106512 GC12M105134 GC12M103692

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CKAP4 Gene:

CKAP4 (cytoskeleton-associated protein 4) is a protein-coding gene. Diseases associated with CKAP4 include steroid-induced glaucoma, and split foot.

UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065

Function: High-affinity epithelial cell surface receptor for APF

Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Wiki entry for CKAP4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the CKAP4 gene promoter:
SRF ER-alpha AhR AML1a MAZR SRF (504 AA) LCR-F1 Arnt HEN1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKAP4 promoter sequence

Search Chromatin IP Primers for CKAP4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKAP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3

CKAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M106631: view genomic region (about GC identifiers)

Start:	106,631,655 bp from pter	End:	106,698,057 bp from pter
Size:	66,403 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065 (See protein sequence)

Recommended Name: Cytoskeleton-associated protein 4

Size: 602 amino acids; 66022 Da

Sequence caution: Sequence=AAH94824.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Secondary accessions: Q504S5 Q53ES6

Explore the universe of human proteins at neXtProt for CKAP4: NX_Q07065

Explore proteomics data for CKAP4 at MOPED

Post-translational modifications:

Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the

plasma membrane and for its perinuclear localization¹

Increased phosphorylation during mitosis prevents binding to microtubules¹

Ubiquitination² at Lys213, Lys355, Lys551

Glycosylation² at Thr512

Modification sites at PhosphoSitePlus

See CKAP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006816.2

ENSEMBL proteins:

ENSP00000367265 ENSP00000449240

CKAP4 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for CKAP4 OriGene Custom MassSpec OriGene Custom Protein Services for CKAP4
	GenScript Custom Purified and Recombinant Proteins Services for CKAP4
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CKAP4
	Search eBioscience for Proteins for CKAP4
	Search antibodies-online for proteins for CKAP4
	antibodies-online peptides for CKAP4

CKAP4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CKAP4
	R&D Systems Antibodies for CKAP4 (CKAP4/p63)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CKAP4
	Novus Biologicals CKAP4 Antibodies
	Abcam antibodies for CKAP4
	Cloud-Clone Corp. Antibodies for CKAP4
	ThermoFisher Antibody for CKAP4
	antibodies-online antibodies for CKAP4 (47 products)

CKAP4 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CKAP4
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CKAP4
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CKAP4 Cloud-Clone Corp. CLIAs for CKAP4
	Search eBioscience for ELISAs for CKAP4
	antibodies-online kits for CKAP4 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR028428 Ckap4

Graphical View of Domain Structure for InterPro Entry Q07065

ProtoNet protein and cluster: Q07065

Find genes that share domains with CKAP4 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: CKAP4_HUMAN, Q07065

Function: High-affinity epithelial cell surface receptor for APF

Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0004871	signal transducer activity	--	--
GO:0044822	poly(A) RNA binding	IDA	--

Find genes that share ontologies with CKAP4 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for CKAP4:

Increased gamma-H2AX phosphory

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for CKAP4

miRNA Products:		miRTarBase miRNAs that target CKAP4: hsa-mir-215-5p (MIRT024515), hsa-mir-30c-5p (MIRT047962), hsa-mir-124-3p (MIRT022457), hsa-mir-615-3p (MIRT040356), hsa-mir-192-5p (MIRT026345), hsa-mir-7-5p (MIRT004057), hsa-mir-1226-3p (MIRT036501), hsa-mir-877-3p (MIRT036830)

		Block miRNA regulation of human, mouse, rat CKAP4 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CKAP4 (see all 32):
		hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CKAP4
		Predesigned siRNA for gene silencing in human, mouse, rat CKAP4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CKAP4

Clone Products:		OriGene clones in human, mouse for CKAP4 (see all 6) OriGene ORF clones in mouse, rat for CKAP4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKAP4 (NM_006825)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKAP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CKAP4
		Browse ESI BIO Cell Lines and PureStem Progenitors for CKAP4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

CKAP4_HUMAN, Q07065: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane;

Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates

to the perinuclear region upon APF-stimulation

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
endoplasmic reticulum	5
plasma membrane	5
nucleus	2
cytosol	1
golgi apparatus	1
mitochondrion	1
peroxisome	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	--	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005811	lipid particle	IDA	14741744
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IEA	--

Find genes that share ontologies with CKAP4 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CKAP4 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

Find genes that share SuperPaths with CKAP4 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Kegg Pathway (Kegg details for CKAP4):

Protein processing in endoplasmic reticulum

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CKAP4
Interactions:

Search GeneGlobe Interaction Network for CKAP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CKAP4 (Q07065^{2, 3} ENSP00000367265⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASCC2	Q9H1I8²^,³	MINT-65466 I2D: score=5
PLAT	P00750³, ENSP00000220809⁴	I2D: score=2 STRING: ENSP00000220809
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
EGFR	P00533³, ENSP00000275493⁴	I2D: score=1 STRING: ENSP00000275493
ULK2	Q8IYT8³, ENSP00000354877⁴	I2D: score=1 STRING: ENSP00000354877

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007165	signal transduction	--	--
GO:0032784	regulation of DNA-templated transcription, elongation	--	--

Find genes that share ontologies with CKAP4 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CKAP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CKAP4 gene:

NM_006825.3

Unigene Cluster for CKAP4:

Cytoskeleton-associated protein 4

Hs.74368 [show with all ESTs]

Unigene Representative Sequence: NM_006825

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378026(uc001tlk.3) ENST00000552828 ENST00000553039

miRNA Products:		Block miRNA regulation of human, mouse, rat CKAP4 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CKAP4 (see all 32):
		hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CKAP4
		Predesigned siRNA for gene silencing in human, mouse, rat CKAP4

Clone Products:		OriGene clones in human, mouse for CKAP4 (see all 6) OriGene ORF clones in mouse, rat for CKAP4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKAP4 (NM_006825)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKAP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP4

Primer Products:		OriGene qPCR primer pairs and template standards for CKAP4 OriGene qSTAR qPCR primer pairs in human, mouse for CKAP4
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CKAP4
		QuantiTect SYBR Green Assays in human, mouse, rat CKAP4
		QuantiFast Probe-based Assays in human, mouse, rat CKAP4

Additional mRNA sequence:

AK123693.1 AK223563.1 BC015436.2 BC025341.1 BC037578.1 BC067357.1 BC082972.1 BC094824.1

S74539.1 X69910.2

19 DOTS entries:

DT.75163974 DT.100798547 DT.87004334 DT.87017480 DT.100798544 DT.121177047 DT.91966429 DT.121177108

DT.100033267 DT.100798551 DT.102834158 DT.121177089 DT.92390396 DT.97859668 DT.100798549 DT.92462151

DT.95155996 DT.121177074 DT.87017481

Selected AceView cDNA sequences (see all 532):

AI866938 AI420840 CA449503 CA388841 AI285040 BF718546 AA303809 AA552534

AA576081 BQ676236 AW008984 AA458979 CF130614 AI018297 BF063195 AL709991

BQ222849 AI675890 CB529506 AI192758 AA429612 BQ679641 CR626523 BU162888

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CKAP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGAGGTTTG

About this image

CKAP4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 8) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Eye (Sensory Organs) fully expand to see all 2 entries
Limbal epithelial stem cells (family)

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Pancreas (Endocrine System)
Islets of Langerhans

CKAP4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CKAP4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.74368

Custom PCR Arrays for CKAP4

Primer Products:		OriGene qPCR primer pairs and template standards for CKAP4 OriGene qSTAR qPCR primer pairs in human, mouse for CKAP4
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CKAP4
		QuantiTect SYBR Green Assays in human, mouse, rat CKAP4
		QuantiFast Probe-based Assays in human, mouse, rat CKAP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKAP4 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ckap4^{1 , 5}	cytoskeleton-associated protein 4^{1, 5}	84.21(n)¹ 83.67(a)¹		10 (41.52 cM)⁵ 216197¹ NM_175451.1¹ NP_780660.1¹ 84526305⁵
chicken (Gallus gallus)	Aves	CKAP4¹	cytoskeleton-associated protein 4	61.95(n) 57.51(a)		418073 XM_416309.4 XP_416309.4
lizard (Anolis carolinensis)	Reptilia	CKAP4⁶	cytoskeleton-associated protein 4	53(a)	1 ↔ 1	5(19117130-19125880)
African clawed frog (Xenopus laevis)	Amphibia	BG554644.1²	--	81.25(n)		BG554644.1
wheat (Triticum aestivum)	Liliopsida	BQ484045.1²	--	70.93(n)		BQ484045.1

ENSEMBL Gene Tree for CKAP4 (if available)
TreeFam Gene Tree for CKAP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for CKAP4 gene

Find genes that share paralogs with CKAP4 About GenesLikeMe

1 Pseudogenes.org Pseudogene for CKAP4
PGOHUM00000233631

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182872619^1,2		--	106484663(+)	`AGGGTA/GTGTTC`	1	--	us2k¹		0	--	--	--	--
rs140063177^1,2	C	--	106631227(+)	`CAGAAA/CCCGGG`	1	--	ds500¹		0	--	--	--	--
rs144093246^1,2	C	--	106631285(+)	`GGTGA-/CA GAGCGCAGAG`	1	--	ds500¹		0	--	--	--	--
rs180925119^1,2		--	106631292(+)	`AGAGCA/GAGACT`	1	--	ds500¹		0	--	--	--	--
rs57612433^1,2	C	--	106631324(+)	`AAAAA-/AAAAAAAA /AAAAAAAAACAGTG`	2	--	ds500¹ cds¹		1		NA	2
rs201240412^1,2	C	--	106631325(-)	`GCACTG/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs11112908^1,2	C,A	--	106631397(+)	`GCTCCT/AAGGAA`	1	--	ds500¹		4		WA NA EA	360
rs143805050^1,2	C	--	106631423(+)	`TGAGGA/GTTGAG`	1	--	ds500¹		0	--	--	--	--
rs117110586^1,2	C,F	--	106631434(+)	`ATCCTG/CTGCTT`	1	--	ds500¹		1		NA	120
rs76047848^1,2		--	106631501(+)	`AAAGGA/TGGTCC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CKAP4 (106631655 - 106698057 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CKAP4: About this table

Variant ID	Type	Subtype	PubMed ID
esv25104	CNV	Loss	19812545

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CKAP4

DNA2.0 Custom Variant and Variant Library Synthesis for CKAP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

2 diseases for CKAP4:
About MalaCards

steroid-induced glaucoma split foot

2 inferred disease relationships from the University of Copenhagen DISEASES database for CKAP4:

Interstitial cystitis steroid-induced glaucoma

Find genes that share disorders with CKAP4 About GenesLikeMe

Export disorders for CKAP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for CKAP4 gene, integrated from 10 sources (see all 80):
(articles sorted by number of sources associating them with CKAP4)

Utopia: connect your pdf to the dynamic
world of online information

A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PubMed id 8314870)^{1, 2, 3} Schweizer A....Hauri H.-P. (J. Cell Sci. 1993)
Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PubMed id 19144824)^{1, 2, 9} Planey S.L.... Zacharias D.A. (Mol. Biol. Cell 2009)
Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PubMed id 15703217)^{1, 2, 9} Vedrenne C.... Hauri H.P. (Mol. Biol. Cell 2005)
CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. (PubMed id 17030514)^{1, 2} Conrads T.P.... Keay S.K. (J. Biol. Chem. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. (PubMed id 11402071)^{1, 9} Klopfenstein D.R....Hauri H.P. (J. Cell Biol. 2001)
Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4). (PubMed id 12913003)^{1, 9} Razzaq T.M....Ellis V. (J. Biol. Chem. 2003)
Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. (PubMed id 17567679)^{2, 9} Nikonov A.V.... Kreibich G. (J. Cell Sci. 2007)
Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells. (PubMed id 23921950)¹ Chen Y....Sen G.L. (J. Invest. Dermatol. 2014)
Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection. (PubMed id 23665508)¹ Li M.H....Wang H.Y. (Cancer Lett. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 10970	HGNC: 16991	AceView: CKAP4	Ensembl:ENSG00000136026	euGenes: HUgn10970
ECgene: CKAP4	Kegg: 10970	H-InvDB: CKAP4

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for CKAP4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CKAP4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CKAP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for CKAP4 gene:
Search GeneIP for patents involving CKAP4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

	Browse Kits and Assays available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CKAP4
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore genomic analysis products

	Antibodies for CKAP4 (CKAP4/p63)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for CKAP4
	OriGene qPCR primer pairs and template standards for CKAP4		OriGene Protein Over-expression Lysate for CKAP4
	OriGene Custom Mass Spec		OriGene clones in human, mouse for CKAP4
	OriGene qSTAR qPCR primer pairs in human, mouse for CKAP4		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for CKAP4		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CKAP4		OriGene Custom Protein Services for CKAP4

	Block miRNA regulation of human, mouse, rat CKAP4 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing CKAP4
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKAP4		Predesigned siRNA for gene silencing in human, mouse, rat CKAP4
	QuantiFast Probe-based Assays in human, mouse, rat CKAP4		QuantiTect SYBR Green Assays in human, mouse, rat CKAP4
	Custom PCR Arrays for CKAP4		Search Chromatin IP Primers for CKAP4
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat CKAP4		Search GeneGlobe Interaction Network for CKAP4
	Regulatory tfbs in CKAP4 promoter

	GenScript Custom Purified and Recombinant Proteins Services for CKAP4		GenScript cDNA clones with any tag delivered in your preferred vector for CKAP4
	GenScript Custom Assay Services for CKAP4		GenScript Custom overexpressing Cell Line Services for CKAP4
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for CKAP4

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CKAP4 antibodies

	Antibodies for CKAP4
	See all of Abcam's Antibodies, Kits and Proteins for CKAP4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for CKAP4
	Antibodies for CKAP4
	ELISAs for CKAP4
	CLIAs for CKAP4

Browse ESI BIO Cell Lines and PureStem Progenitors for CKAP4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

	SwitchGear 3'UTR luciferase reporter plasmids for CKAP4
	SwitchGear Promoter luciferase reporter plasmids for CKAP4

ThermoFisher Antibody for CKAP4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP4

Browse compounds at ApexBio

Search Addgene for plasmids for CKAP4

	Search eBioscience for proteins for CKAP4
	Search eBioscience for elisas for CKAP4
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for CKAP4

	antibodies-online antibodies for CKAP4 (47 products)
	antibodies-online kits for CKAP4 (4 products)
	antibodies-online peptides for CKAP4
	Search antibodies-online for proteins for CKAP4

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CKAP4 gene at Home site.

Version: 3.12.304 29 Jan 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

CKAP4 Gene

Cytoskeleton-Associated Protein 4

Aliases
for CKAP4 gene

Summaries
for CKAP4 gene

Genomic Views
for CKAP4 gene

Proteins
for CKAP4 gene

CKAP4 Human Recombinant Protein Products:

CKAP4 Antibody Products:

CKAP4 Assay Products:

Domains /
Families
for CKAP4 gene

Function
for CKAP4 gene

Localization
for CKAP4 gene

Pathways & Interactions
for CKAP4 gene

Drugs & Compounds
for CKAP4 gene

Transcripts
for CKAP4 gene

Expression
for CKAP4 gene

Orthologs
for CKAP4 gene

Paralogs
for CKAP4 gene

Genomic Variants
for CKAP4 gene

Disorders / Diseases
for CKAP4 gene

Publications
for CKAP4 gene

External Searches for CKAP4 gene

Genome Databases showing CKAP4 gene

Other Databases showing CKAP4 gene

Specialized Databases showing CKAP4 gene

Intellectual Property
for CKAP4 gene

Products
for CKAP4 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

CKAP4 Gene

Cytoskeleton-Associated Protein 4

Aliasesfor CKAP4 gene

Summariesfor CKAP4 gene

Genomic Viewsfor CKAP4 gene

Proteinsfor CKAP4 gene

CKAP4 Human Recombinant Protein Products:

CKAP4 Antibody Products:

CKAP4 Assay Products:

Domains /Familiesfor CKAP4 gene

Functionfor CKAP4 gene

Localizationfor CKAP4 gene

Pathways & Interactionsfor CKAP4 gene

Drugs & Compoundsfor CKAP4 gene

Transcriptsfor CKAP4 gene

Expression for CKAP4 gene

Orthologsfor CKAP4 gene

Paralogsfor CKAP4 gene

Genomic Variantsfor CKAP4 gene

Disorders / Diseasesfor CKAP4 gene

Publicationsfor CKAP4 gene

External Searches for CKAP4 gene

Genome Databases showing CKAP4 gene

Other Databases showing CKAP4 gene

Specialized Databases showing CKAP4 gene

Intellectual Propertyfor CKAP4 gene

Productsfor CKAP4 gene

View Random Gene

Aliases
for CKAP4 gene

Summaries
for CKAP4 gene

Genomic Views
for CKAP4 gene

Proteins
for CKAP4 gene

Domains /
Families
for CKAP4 gene

Function
for CKAP4 gene

Localization
for CKAP4 gene

Pathways & Interactions
for CKAP4 gene

Drugs & Compounds
for CKAP4 gene

Transcripts
for CKAP4 gene

Expression
for CKAP4 gene

Orthologs
for CKAP4 gene

Paralogs
for CKAP4 gene

Genomic Variants
for CKAP4 gene

Disorders / Diseases
for CKAP4 gene

Publications
for CKAP4 gene

Intellectual Property
for CKAP4 gene

Products
for CKAP4 gene