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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CKAP4 Gene

protein-coding   GIFtS: 57
GCID: GC12M106631

Cytoskeleton-Associated Protein 4
  See related diseases
at
MalaCards
 

Aliases
for CKAP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Cytoskeleton-Associated Protein 41 2     ERGIC-632
63-KDa Cytoskeleton-Linking Membrane Protein2 3     Transmembrane Protein (63kD), Endoplasmic Reticulum/Golgi Intermediate
Compartment2
p632 3     Type-II Transmembrane Protein P632
63 KDa Membrane Protein2     Climp-633
CLIMP-632     

External Ids:    HGNC: 169911   Entrez Gene: 109702   Ensembl: ENSG000001360267   UniProtKB: Q070653   

Export aliases for CKAP4 gene to outside databases

Previous GC identifers: GC12M105742 GC12M106512 GC12M105134 GC12M103692


Summaries
for CKAP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for CKAP4 Gene: 
CKAP4 (cytoskeleton-associated protein 4) is a protein-coding gene. Diseases associated with CKAP4 include steroid-induced glaucoma, and chronic interstitial cystitis.

UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065
Function: High-affinity epithelial cell surface receptor for APF
Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Wiki entry for CKAP4 Gene


Genomic Views
for CKAP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKAP4 gene promoter:
         SRF   ER-alpha   AhR   AML1a   MAZR   SRF (504 AA)   LCR-F1   Arnt   HEN1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKAP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CKAP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

CKAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M106631:  view genomic region     (about GC identifiers)

Start:
 106,631,655 bp from pter      End:
 106,698,057 bp from pter
Size:
 66,403 bases      Orientation:
 minus strand

Proteins
for CKAP4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065 (See protein sequence)
Recommended Name: Cytoskeleton-associated protein 4  
Size: 602 amino acids; 66022 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane;
Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates
to the perinuclear region upon APF-stimulation
Sequence caution: Sequence=AAH94824.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q504S5 Q53ES6

Explore the universe of human proteins at neXtProt for CKAP4: NX_Q07065

Explore proteomics data for CKAP4 at MOPED 

Post-translational modifications:

  • UniProtKB: Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the
    plasma membrane and for its perinuclear localization
  • UniProtKB: Increased phosphorylation during mitosis prevents binding to microtubules
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07065

    • CKAP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CKAP4 Protein Expression
    REFSEQ proteins: NP_006816.2  
    ENSEMBL proteins: 
     ENSP00000367265   ENSP00000449240  

    Human Recombinant Protein Products for CKAP4: 
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    OriGene Protein Over-expression Lysate for CKAP4
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CKAP4 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005811lipid particle IDA14741744
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--

    CKAP4 for ontologies           About GeneDecksing



    CKAP4 Antibody Products: 
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    Assay Products for CKAP4: 
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    Cloud-Clone Corp. ELISAs for CKAP4 
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    Protein Domains /
    Families
    for CKAP4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q07065


    Function
    for CKAP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CKAP4_HUMAN, Q07065
    Function: High-affinity epithelial cell surface receptor for APF
    Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0004871signal transducer activity ----
         
    CKAP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CKAP4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CKAP4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CKAP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKAP4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKAP4 

    miRNA
    Products:            		miRTarBase miRNAs that target CKAP4:
    hsa-mir-7 (MIRT004057)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKAP4
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate CKAP4 (see all 32):
    hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CKAP4

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CKAP4 

    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for CKAP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CKAP4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for CKAP4):
        Protein processing in endoplasmic reticulum


    CKAP4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CKAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for CKAP4 (Q070652, 3 ENSP000003672654) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCC2Q9H1I82, 3MINT-65466 I2D: score=5 
    PLATP007503, ENSP000002208094I2D: score=2 STRING: ENSP00000220809
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    ULK2Q8IYT83, ENSP000003548774I2D: score=1 STRING: ENSP00000354877
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007165signal transduction ----
    GO:0032784regulation of DNA-dependent transcription, elongation ----

    CKAP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CKAP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKAP4

    Search CenterWatch for drugs/clinical trials and news about CKAP4

    Transcripts
    for CKAP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CKAP4 gene: 
    NM_006825.3  

    Unigene Cluster for CKAP4:

    Cytoskeleton-associated protein 4
    Hs.74368  [show with all ESTs]
    Unigene Representative Sequence: NM_006825
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378026(uc001tlk.3) ENST00000552828 ENST00000553039
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKAP4
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate CKAP4 (see all 32):
    hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP4
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKAP4

    Additional mRNA sequence: 

    AK123693.1 AK223563.1 BC015436.2 BC025341.1 BC037578.1 BC067357.1 BC082972.1 BC094824.1 
    S74539.1 X69910.2 

    19 DOTS entries:

    DT.75163974  DT.100798547  DT.87004334  DT.87017480  DT.100798544  DT.121177047  DT.91966429  DT.121177108 
    DT.100033267  DT.100798551  DT.102834158  DT.121177089  DT.92390396  DT.97859668  DT.100798549  DT.92462151 
    DT.95155996  DT.121177074  DT.87017481 

    24/532 AceView cDNA sequences (see all 532):

    AI131495 BF063195 BU627193 BQ446309 BQ683948 AI934723 CA388841 BU162434 
    CA388840 BE551693 BQ679725 CA447044 CA449503 AA429611 W37725 CA489350 
    BX394601 BU184761 BE257937 BM722810 AA303436 AI066657 BG413578 AI523686 

    GeneLoc Exon Structure


    Expression
    for CKAP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CKAP4 expression in normal human tissues (normalized intensities)      CKAP4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGGTTTG
    CKAP4 Expression
    About this image


    CKAP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See CKAP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CKAP4

    SOURCE GeneReport for Unigene cluster: Hs.74368
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    In Situ
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    Orthologs
    for CKAP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CKAP4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ckap41 , 5 cytoskeleton-associated protein 41, 5 85.19(n)1
    83.97(a)1    		   10 (41.52 cM)5
    2161971  NM_175451.11  NP_780660.11 
     845263055 
    chicken
    (Gallus gallus)    		 Aves CKAP41 cytoskeleton-associated protein 4 62(n)
    57.75(a)    		   418073  XM_416309.3  XP_416309.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CKAP46
    		 Uncharacterized protein
    		 49(a)
    		 1 ↔ 1
    		 5(19117130-19125880)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BG554644.12   -- 81.25(n)    BG554644.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:859751 zgc:85975 46.7(n)
    25.89(a)    		   406549  NM_213265.1  NP_998430.1 
    wheat
    (Triticum aestivum)    		 Liliopsida BQ484045.12   -- 70.93(n)    BQ484045.1 


    ENSEMBL Gene Tree for CKAP4 (if available)
    TreeFam Gene Tree for CKAP4 (if available)

    Paralogs
    for CKAP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CKAP4 gene

    CKAP4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CKAP4
    PGOHUM00000233631


    Genomic Variants
    for CKAP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/326 SNPs in CKAP4 are shown (see all 326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1828726191,2
    		--106484663(+) AGGGTA/GTGTTC 1 -- us2k10--------
    rs1400631771,2
    		C--106631227(+) CAGAAA/CCCGGG 1 -- ds50010--------
    rs1440932461,2
    		C--106631285(+) GGTGA-/CA    
       GAGCG    CAGAG     		1 -- ds50010--------
    rs1809251191,2
    		--106631292(+) AGAGCA/GAGACT 1 -- ds50010--------
    rs576124331,2
    		C--106631324(+) AAAAA-/AAAAAAAA
    /AAAAAAAAA    CAGTG     		2 -- ds5001 cds11NA 2
    rs2012404121,2
    		C--106631325(-) GCACTG/TTTTTT 1 -- ds50010--------
    rs111129081,2
    		C,A--106631397(+) GCTCCT/AAGGAA 1 -- ds50014Minor allele frequency- A:0.26WA NA EA 360
    rs1438050501,2
    		C--106631423(+) TGAGGA/GTTGAG 1 -- ds50010--------
    rs1171105861,2
    		C,F--106631434(+) ATCCTG/CTGCTT 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs760478481,2
    		--106631501(+) AAAGGA/TGGTCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CKAP4 (106631655 - 106698057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CKAP4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv25104CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CKAP4
    DNA2.0 Custom Variant and Variant Library Synthesis for CKAP4

    Disorders / Diseases
    for CKAP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 13 diseases for CKAP4:    About MalaCards
    steroid-induced glaucoma    chronic interstitial cystitis    cystitis    split foot
    n syndrome    amelogenesis imperfecta    bladder carcinoma    glaucoma
    squamous cell carcinoma    melanoma    endotheliitis    neuronitis
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for CKAP4:
    Interstitial cystitis     steroid-induced glaucoma

    CKAP4 for disorders           About GeneDecksing


    Export disorders for CKAP4 gene to outside databases

    Publications
    for CKAP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CKAP4 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with CKAP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PubMed id 8314870)1, 2, 3 Schweizer A....Hauri H.-P. (1993)
    2. Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PubMed id 19144824)1, 2, 9 Planey S.L....Zacharias D.A. (2009)
    3. Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PubMed id 15703217)1, 2, 9 Vedrenne C....Hauri H.P. (2005)
    4. CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. (PubMed id 17030514)1, 2 Conrads T.P....Keay S.K. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. (PubMed id 11402071)1, 9 Klopfenstein D.R....Hauri H.P. (2001)
    7. Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4). (PubMed id 12913003)1, 9 Razzaq T.M....Ellis V. (2003)
    8. Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. (PubMed id 17567679)2, 9 Nikonov A.V....Kreibich G. (2007)
    9. Expression of cytoskeleton-associated protein 4 is rel ated to lymphatic metastasis and indicates prognosis of intrahepatic cholangioca rcinoma patients after surgery resection. (PubMed id 23665508)1 Li M.H....Wang H.Y. (2013)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    External Searches for CKAP4 gene

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    Genome Databases showing CKAP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10970 HGNC: 16991 AceView: CKAP4 Ensembl:ENSG00000136026 euGenes: HUgn10970
    ECgene: CKAP4 Kegg: 10970 H-InvDB: CKAP4

    Other Databases showing CKAP4 gene

    (According to HUGE)
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    Specialized Databases showing CKAP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CKAP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CKAP4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CKAP4 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
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