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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CKAP4 Gene

protein-coding GIFtS: 55
GCID: GC12M106631

cytoskeleton-associated protein 4

Explore 11 diseases affiliated with
CKAP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytoskeleton-Associated Protein 4¹ ²		P63¹
CLIMP-63¹ ²		63 KDa Membrane Protein²
ERGIC-63¹ ²		Transmembrane Protein (63kD), Endoplasmic Reticulum/Golgi Intermediate Compartment²
63-KDa Cytoskeleton-Linking Membrane Protein² ³		Type-II Transmembrane Protein P63²
P63¹		Climp-63³

External Ids:	HGNC: 16991¹	Entrez Gene: 10970²	Ensembl: ENSG00000136026⁷	UniProtKB: Q07065³

Export aliases for CKAP4 gene to outside databases

Previous GC identifers: GC12M105742 GC12M106512 GC12M105134 GC12M103692

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065

Function: High-affinity epithelial cell surface receptor for APF

Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Wiki entry for CKAP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CKAP4 gene promoter:
SRF ER-alpha AhR AML1a MAZR SRF (504 AA) LCR-F1 Arnt HEN1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKAP4 promoter sequence

Search SABiosciences Chromatin IP Primers for CKAP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKAP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3

CKAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M106631: view genomic region (about GC identifiers)

Start:	106,631,655 bp from pter	End:	106,698,057 bp from pter
Size:	66,403 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065 (See protein sequence)

Recommended Name: Cytoskeleton-associated protein 4

Size: 602 amino acids; 66022 Da

Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass

type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear

region upon APF-stimulation

Sequence caution: Sequence=AAH94824.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Secondary accessions: Q504S5 Q53ES6

Explore the universe of human proteins at neXtProt for CKAP4: NX_Q07065

Post-translational modifications:

Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma

membrane and for its perinuclear localization¹

Increased phosphorylation during mitosis prevents binding to microtubules¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07065

CKAP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006816.2

ENSEMBL proteins:

ENSP00000367265 ENSP00000449240

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CKAP4

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005783	endoplasmic reticulum	--	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005811	lipid particle	IDA	14741744
GO:0005856	cytoskeleton	IEA	--

CKAP4 for ontologies About GeneDecksing

CKAP4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CKAP4 (CKAP4/p63)
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	GenScript Custom Superior Antibodies Services for CKAP4
	Novus Biologicals CKAP4 Antibodies
	Search for Antibodies for CKAP4 at Abcam
	Uscn Antibodies for CKAP4
	Search ThermoFisher Antibodies for CKAP4

Assay Products for CKAP4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CKAP4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CKAP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q07065

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065

Function: High-affinity epithelial cell surface receptor for APF

Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

miRNA Products:		miRTarBase miRNAs that target CKAP4: hsa-mir-7 (MIRT004057)

		OriGene 3'-UTR Clone: CKAP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKAP4
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate CKAP4 (see all 32):
		hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKAP4 (see all 7) OriGene shRNA RFP: CKAP4 OriGene siRNA: CKAP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKAP4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CKAP4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKAP4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKAP4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKAP4 (NM_006825)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKAP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CKAP4
		Search LifeMap BioReagents cell lines for CKAP4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

1 GenomeRNAi human phenotype for CKAP4:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for CKAP4):

Protein processing in endoplasmic reticulum

CKAP4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CKAP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/43 Interacting proteins for CKAP4 (Q07065^{2, 3} ENSP00000367265⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASCC2	Q9H1I8²^,³	MINT-65466 I2D: score=5
PLAT	P00750³, ENSP00000220809⁴	I2D: score=2 STRING: ENSP00000220809
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
EGFR	P00533³, ENSP00000275493⁴	I2D: score=1 STRING: ENSP00000275493
ULK2	Q8IYT8³, ENSP00000354877⁴	I2D: score=1 STRING: ENSP00000354877

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CKAP4
Search CenterWatch for drugs/clinical trials and news about CKAP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CKAP4 gene:

NM_006825.3

Unigene Cluster for CKAP4:

Cytoskeleton-associated protein 4

Hs.74368 [show with all ESTs]

Unigene Representative Sequence: NM_006825

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378026(uc001tlk.3) ENST00000552828 ENST00000553039

miRNA Products:		OriGene 3'-UTR Clone: CKAP4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CKAP4
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate CKAP4 (see all 32):
		hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKAP4 (see all 7) OriGene shRNA RFP: CKAP4 OriGene siRNA: CKAP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CKAP4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CKAP4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CKAP4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CKAP4 (NM_006825)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CKAP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKAP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CKAP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKAP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKAP4

Additional cDNA sequence:

AK123693.1 AK223563.1 BC015436.2 BC025341.1 BC037578.1 BC067357.1 BC082972.1 BC094824.1

S74539.1 X69910.2

21 DOTS entries:

DT.75163974 DT.100798547 DT.87004334 DT.87017480 DT.100798544 DT.121177108 DT.91966429 DT.121177047

DT.102834158 DT.121177074 DT.100033267 DT.100798551 DT.121177089 DT.92390396 DT.100798549 DT.97859668

DT.87017481 DT.92462151 DT.95155996 DT.95156014 DT.121177048

24/532 AceView cDNA sequences (see all 532):

AI131495 CB215299 CA420773 CO248192 AI350353 CA487252 BU679777 BQ683948

BQ677768 BQ182627 BU174197 BM679707 AU117654 AA293014 AI989518 BX105004

CA438041 AI285040 BC025341 BC015436 BM766340 AI340254 BQ897558 BQ679725

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CKAP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAGGTTTG

About this image

CKAP4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CKAP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CKAP4

SOURCE GeneReport for Unigene cluster: Hs.74368

SABiosciences Custom PCR Arrays for CKAP4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKAP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CKAP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CKAP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CKAP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CKAP4 gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ckap4^{1 , 5}	cytoskeleton-associated protein 4^{1, 5}	85.19(n)¹ 83.97(a)¹		10 (41.52 cM)⁵ 216197¹ NM_175451.1¹ NP_780660.1¹ 84526305⁵
chicken (Gallus gallus)	Aves	CKAP4¹	cytoskeleton-associated protein 4	62(n) 57.75(a)		418073 XM_416309.3 XP_416309.3
lizard (Anolis carolinensis)	Reptilia	CKAP4⁶	--	52(a)	1 ↔ 1	5(19119275-19125375)
African clawed frog (Xenopus laevis)	Amphibia	BG554644.1²	--	81.25(n)		BG554644.1
zebrafish (Danio rerio)	Actinopterygii	zgc:85975¹	zgc:85975	46.7(n) 25.89(a)		406549 NM_213265.1 NP_998430.1
wheat (Triticum aestivum)	Liliopsida	BQ484045.1²	--	70.93(n)		BQ484045.1

ENSEMBL Gene Tree for CKAP4 (if available)
TreeFam Gene Tree for CKAP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CKAP4 gene

CKAP4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CKAP4
PGOHUM00000233631

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140063177^1,2		--	106631227(+)	`CAGAAA/CCCGGG`	1	--	ds500¹		0	--	--	--	--
rs144093246^1,2	C,	--	106631285(+)	`GGTGA-/CA GAGCGCAGAG`	1	--	ds500¹		0	--	--	--	--
rs180925119^1,2		--	106631292(+)	`AGAGCA/GAGACT`	1	--	ds500¹		0	--	--	--	--
rs201240412^1,2	C	--	106631325(-)	`GCACTG/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs11112908^1,2	C,A,	--	106631397(+)	`GCTCCT/AAGGAA`	1	--	ds500¹		4		WA NA EA	360
rs143805050^1,2		--	106631423(+)	`TGAGGA/GTTGAG`	1	--	ds500¹		0	--	--	--	--
rs117110586^1,2	F,	--	106631434(+)	`ATCCTG/CTGCTT`	1	--	ds500¹		1		NA	120
rs76047848^1,2		--	106631501(+)	`AAAGGA/TGGTCC`	1	--	ds500¹		0	--	--	--	--
rs140645485^1,2		--	106631530(+)	`CATCTC/TGGTTT`	1	--	ds500¹		0	--	--	--	--
rs144051764^1,2	C,	--	106631761(+)	`TTTTT-/ACTTTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CKAP4 (106631655 - 106698057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CKAP4
1 CNV: 66320

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKAP4

DNA2.0 Custom Variant and Variant Library Synthesis for CKAP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CKAP4 for disorders About GeneDecksing

11 diseases for CKAP4: About MalaCards

interstitial cystitis amelogenesis imperfecta cystitis n syndrome

ectrodactyly squamous cell carcinoma bladder carcinoma breast carcinoma

carcinoma melanoma neuronitis

3 diseases from the University of Copenhagen DISEASES database for CKAP4:

Interstitial cystitis Chronic interstitial cystitis steroid-induced glaucoma

Export disorders for CKAP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CKAP4 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with CKAP4)

Utopia: connect your pdf to the dynamic
world of online information

A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PubMed id 8314870)^{1, 2, 3} Schweizer A....Hauri H.-P. (1993)
Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PubMed id 19144824)^{1, 2, 9} Planey S.L....Zacharias D.A. (2009)
Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PubMed id 15703217)^{1, 2, 9} Vedrenne C....Hauri H.P. (2005)
CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. (PubMed id 17030514)^{1, 2} Conrads T.P....Keay S.K. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. (PubMed id 11402071)^{1, 9} Klopfenstein D.R....Hauri H.P. (2001)
Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4). (PubMed id 12913003)^{1, 9} Razzaq T.M....Ellis V. (2003)
Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. (PubMed id 17567679)^{2, 9} Nikonov A.V....Kreibich G. (2007)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Surfactant protein A blocks recognition of Pseudomonas aeruginosa by CKAP4/P63 on airway epithelial cells. (PubMed id 22966120)¹ Barbier M....Alberti S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10970	HGNC: 16991	AceView: CKAP4	Ensembl:ENSG00000136026	euGenes: HUgn10970
ECgene: CKAP4	Kegg: 10970	H-InvDB: CKAP4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CKAP4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CKAP4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CKAP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CKAP4 gene:
Search GeneIP for patents involving CKAP4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Antibodies for CKAP4 (CKAP4/p63)		Browse Cell Culture Products
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	Browse OriGene Antibodies		OriGene shRNA RFP for CKAP4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CKAP4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CKAP4
	OriGene Protein Over-expression Lysate for CKAP4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CKAP4		OriGene 3'-UTR Clone for CKAP4
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	OriGene Custom Antibody Services for CKAP4		OriGene Custom Protein Services for CKAP4
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CKAP4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CKAP4
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	GenScript Custom Purified and Recombinant Proteins Services for CKAP4		GenScript cDNA clones with any tag delivered in your preferred vector for CKAP4
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	GenScript Custom overexpressing Cell Line Services for CKAP4		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for CKAP4 at Abcam
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CKAP4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CKAP4

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

	SwitchGear 3'UTR luciferase reporter plasmids for CKAP4
	SwitchGear Promoter luciferase reporter plasmids for CKAP4

Search ThermoFisher Antibodies for CKAP4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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CKAP4 Gene

cytoskeleton-associated protein 4

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CKAP4 Gene

cytoskeleton-associated protein 4

Aliasesfor CKAP4 gene

Summariesfor CKAP4 gene

Genomic Viewsfor CKAP4 gene

Proteinsfor CKAP4 gene

Protein Domains /Familiesfor CKAP4 gene

Functionfor CKAP4 gene

Pathways & Interactionsfor CKAP4 gene

Drugs & Compoundsfor CKAP4 gene

Transcriptsfor CKAP4 gene

Expression for CKAP4 gene

Orthologsfor CKAP4 gene

Paralogsfor CKAP4 gene

Genomic Variantsfor CKAP4 gene

Disorders / Diseasesfor CKAP4 gene

Publicationsfor CKAP4 gene

External Searches for CKAP4 gene

Genome Databases showing CKAP4 gene

Other Databases showing CKAP4 gene

Specialized Databases showing CKAP4 gene

Intellectual Propertyfor CKAP4 gene

Productsfor CKAP4 gene

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Aliases
for CKAP4 gene

Summaries
for CKAP4 gene

Genomic Views
for CKAP4 gene

Proteins
for CKAP4 gene

Protein Domains /
Families
for CKAP4 gene

Function
for CKAP4 gene

Pathways & Interactions
for CKAP4 gene

Drugs & Compounds
for CKAP4 gene

Transcripts
for CKAP4 gene

Expression
for CKAP4 gene

Orthologs
for CKAP4 gene

Paralogs
for CKAP4 gene

Genomic Variants
for CKAP4 gene

Disorders / Diseases
for CKAP4 gene

Publications
for CKAP4 gene

Intellectual Property
for CKAP4 gene

Products
for CKAP4 gene