CKAP4 Gene

Aliases
for CKAP4 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC12M105742 GC12M106512 GC12M105134 GC12M103692

Summaries
for CKAP4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CKAP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NC_018923.2  NT_029419.13  

SwitchGear Promoter luciferase reporter plasmid: CKAP4 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKAP4

CKAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M106631:  view genomic region     (about GC identifiers)

Proteins
for CKAP4 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CKAP4: NX_Q07065

Explore proteomics data for CKAP4 at MOPED

Post-translational modifications: 

CKAP4 Human Recombinant Protein Products:

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	antibodies-online peptides for CKAP4

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CKAP4 Assay Products:

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Domains /
Families
for CKAP4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q07065

Function
for CKAP4 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for CKAP4

miRNA Products:		miRTarBase miRNAs that target CKAP4: hsa-mir-215-5p (MIRT024515), hsa-mir-30c-5p (MIRT047962), hsa-mir-124-3p (MIRT022457), hsa-mir-615-3p (MIRT040356), hsa-mir-192-5p (MIRT026345), hsa-mir-7-5p (MIRT004057), hsa-mir-1226-3p (MIRT036501), hsa-mir-877-3p (MIRT036830)
		Block miRNA regulation of human, mouse, rat CKAP4 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CKAP4 (see all 32):
		hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653
		SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

Localization
for CKAP4 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	5
endoplasmic reticulum	5
plasma membrane	5
nucleus	2
cytosol	1
golgi apparatus	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

Pathways & Interactions
for CKAP4 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CKAP4 About     See pathways by source

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	SuperPath	Contained pathways About
1	Protein processing in endoplasmic reticulum	Protein processing in endoplasmic reticulum

1 Kegg Pathway  (Kegg details for CKAP4)

Protein processing in endoplasmic reticulum

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for CKAP4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CKAP4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CKAP4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CKAP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGAGGTTTG

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Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Ovary (Reproductive System)    fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct
Eye (Sensory Organs)    fully expand to see all 2 entries
Limbal epithelial stem cells (family)
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Pancreas (Endocrine System)
Islets of Langerhans

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

Orthologs
for CKAP4 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CKAP4 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CKAP4 gene

Find genes that share paralogs with CKAP4           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CKAP4
PGOHUM00000233631

Genomic Variants
for CKAP4 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CKAP4 (see all 326)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1828726191,2		--	106484663(+)	AGGGTA/GTGTTC	1	--	us2k1		0	--	--	--	--
rs1400631771,2	C	--	106631227(+)	CAGAAA/CCCGGG	1	--	ds5001		0	--	--	--	--
rs1440932461,2	C	--	106631285(+)	GGTGA-/CA        GAGCGCAGAG	1	--	ds5001		0	--	--	--	--
rs1809251191,2		--	106631292(+)	AGAGCA/GAGACT	1	--	ds5001		0	--	--	--	--
rs576124331,2	C	--	106631324(+)	AAAAA-/AAAAAAAA /AAAAAAAAACAGTG	2	--	ds5001 cds1		1		NA	2
rs2012404121,2	C	--	106631325(-)	GCACTG/TTTTTT	1	--	ds5001		0	--	--	--	--
rs111129081,2	C,A	--	106631397(+)	GCTCCT/AAGGAA	1	--	ds5001		4		WA NA EA	360
rs1438050501,2	C	--	106631423(+)	TGAGGA/GTTGAG	1	--	ds5001		0	--	--	--	--
rs1171105861,2	C,F	--	106631434(+)	ATCCTG/CTGCTT	1	--	ds5001		1		NA	120
rs760478481,2		--	106631501(+)	AAAGGA/TGGTCC	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for CKAP4 (106631655 - 106698057 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CKAP4:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv25104	CNV	Loss	19812545

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CKAP4

DNA2.0 Custom Variant and Variant Library Synthesis for CKAP4

Disorders / Diseases
for CKAP4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for CKAP4 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CKAP4 gene, integrated from 10 sources (see all 80): (articles sorted by number of sources associating them with CKAP4)

Utopia: connect your pdf to the dynamic world of online information

1. A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PubMed id 8314870)^{1, 2, 3} Schweizer A....Hauri H.-P. (J. Cell Sci. 1993)
2. Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PubMed id 19144824)^{1, 2, 9} Planey S.L.... Zacharias D.A. (Mol. Biol. Cell 2009)
3. Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PubMed id 15703217)^{1, 2, 9} Vedrenne C.... Hauri H.P. (Mol. Biol. Cell 2005)
4. CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. (PubMed id 17030514)^{1, 2} Conrads T.P.... Keay S.K. (J. Biol. Chem. 2006)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. (PubMed id 11402071)^{1, 9} Klopfenstein D.R....Hauri H.P. (J. Cell Biol. 2001)
7. Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4). (PubMed id 12913003)^{1, 9} Razzaq T.M....Ellis V. (J. Biol. Chem. 2003)
8. Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. (PubMed id 17567679)^{2, 9} Nikonov A.V.... Kreibich G. (J. Cell Sci. 2007)
9. Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells. (PubMed id 23921950)¹ Chen Y....Sen G.L. (J. Invest. Dermatol. 2014)
10. Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection. (PubMed id 23665508)¹ Li M.H....Wang H.Y. (Cancer Lett. 2013)

External Searches for CKAP4 gene

Genome Databases showing CKAP4 gene

Other Databases showing CKAP4 gene

Specialized Databases showing CKAP4 gene

Products
for CKAP4 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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