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Set Analyses:

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CKAP4 Gene

protein-coding GIFtS: 58
GCID: GC12M106631

Cytoskeleton-Associated Protein 4

Pneumococci & Pneumococcal Diseases Congress

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Cytoskeleton-Associated Protein 4¹ ²		ERGIC-63²
63-KDa Cytoskeleton-Linking Membrane Protein² ³		Transmembrane Protein (63kD), Endoplasmic Reticulum/Golgi Intermediate Compartment²
p63² ³		Type-II Transmembrane Protein P63²
63 KDa Membrane Protein²		Climp-63³
CLIMP-63²

External Ids:	HGNC: 16991¹	Entrez Gene: 10970²	Ensembl: ENSG00000136026⁷	UniProtKB: Q07065³

Export aliases for CKAP4 gene to outside databases

Previous GC identifers: GC12M105742 GC12M106512 GC12M105134 GC12M103692

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CKAP4 Gene:

CKAP4 (cytoskeleton-associated protein 4) is a protein-coding gene. Diseases associated with CKAP4 include steroid-induced glaucoma, and chronic interstitial cystitis.

UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065

Function: High-affinity epithelial cell surface receptor for APF

Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Wiki entry for CKAP4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000012.12 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the CKAP4 gene promoter:
SRF ER-alpha AhR AML1a MAZR SRF (504 AA) LCR-F1 Arnt HEN1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKAP4 promoter sequence

Search Chromatin IP Primers for CKAP4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKAP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3

CKAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M106631: view genomic region (about GC identifiers)

Start:	106,631,655 bp from pter	End:	106,698,057 bp from pter
Size:	66,403 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CKAP4_HUMAN, Q07065 (See protein sequence)

Recommended Name: Cytoskeleton-associated protein 4

Size: 602 amino acids; 66022 Da

Sequence caution: Sequence=AAH94824.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Secondary accessions: Q504S5 Q53ES6

Explore the universe of human proteins at neXtProt for CKAP4: NX_Q07065

Explore proteomics data for CKAP4 at MOPED

Post-translational modifications:

Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the

plasma membrane and for its perinuclear localization¹

Increased phosphorylation during mitosis prevents binding to microtubules¹

Ubiquitination² at Lys213, Lys355, Lys551

Glycosylation² at Thr512

Modification sites at PhosphoSitePlus

See CKAP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006816.2

ENSEMBL proteins:

ENSP00000367265 ENSP00000449240

CKAP4 Human Recombinant Protein Products:

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CKAP4 Assay Products:

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	Cloud-Clone Corp. ELISAs for CKAP4 Cloud-Clone Corp. CLIAs for CKAP4

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR028428 Ckap4

Graphical View of Domain Structure for InterPro Entry Q07065

ProtoNet protein and cluster: Q07065

CKAP4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CKAP4_HUMAN, Q07065

Function: High-affinity epithelial cell surface receptor for APF

Function: Mediates the anchoring of the endoplasmic reticulum to microtubules

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0004871	signal transducer activity	--	--
GO:0044822	poly(A) RNA binding	IDA	--

CKAP4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CKAP4:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CKAP4

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CKAP4

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CKAP4

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CKAP4

miRNA Products:		miRTarBase miRNAs that target CKAP4: hsa-mir-215-5p (MIRT024515), hsa-mir-30c-5p (MIRT047962), hsa-mir-124-3p (MIRT022457), hsa-mir-615-3p (MIRT040356), hsa-mir-192-5p (MIRT026345), hsa-mir-7-5p (MIRT004057), hsa-mir-1226-3p (MIRT036501), hsa-mir-877-3p (MIRT036830)

		Block miRNA regulation of human, mouse, rat CKAP4 using miScript Target Protectors
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		hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CKAP4_HUMAN, Q07065: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane;

Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates

to the perinuclear region upon APF-stimulation

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
endoplasmic reticulum	5
plasma membrane	5
nucleus	2
cytosol	1
golgi apparatus	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): Selected cellular component terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	--	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005811	lipid particle	IDA	14741744
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IEA	--

CKAP4 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CKAP4 About

See pathways by source

SuperPath

Contained pathways About

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

Pathways by source See SuperPaths
Show all pathways

1 Kegg Pathway (Kegg details for CKAP4):

Protein processing in endoplasmic reticulum

CKAP4 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CKAP4
Interactions:

Search GeneGlobe Interaction Network for CKAP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CKAP4 (Q07065^{2, 3} ENSP00000367265⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASCC2	Q9H1I8²^,³	MINT-65466 I2D: score=5
PLAT	P00750³, ENSP00000220809⁴	I2D: score=2 STRING: ENSP00000220809
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
EGFR	P00533³, ENSP00000275493⁴	I2D: score=1 STRING: ENSP00000275493
ULK2	Q8IYT8³, ENSP00000354877⁴	I2D: score=1 STRING: ENSP00000354877

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007165	signal transduction	--	--
GO:0032784	regulation of DNA-templated transcription, elongation	--	--

CKAP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CKAP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CKAP4 gene:

NM_006825.3

Unigene Cluster for CKAP4:

Cytoskeleton-associated protein 4

Hs.74368 [show with all ESTs]

Unigene Representative Sequence: NM_006825

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378026(uc001tlk.3) ENST00000552828 ENST00000553039

miRNA Products:		Block miRNA regulation of human, mouse, rat CKAP4 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CKAP4 (see all 32):
		hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-448 hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: CKAP4 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: CKAP4 (NM_006825)
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Primer Products:		OriGene qPCR primer pairs and template standards for CKAP4 OriGene qSTAR qPCR primer pairs in human, mouse for CKAP4
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CKAP4
		QuantiTect SYBR Green Assays in human, mouse, rat CKAP4
		QuantiFast Probe-based Assays in human, mouse, rat CKAP4

Additional mRNA sequence:

AK123693.1 AK223563.1 BC015436.2 BC025341.1 BC037578.1 BC067357.1 BC082972.1 BC094824.1

S74539.1 X69910.2

19 DOTS entries:

DT.75163974 DT.100798547 DT.87004334 DT.87017480 DT.100798544 DT.121177047 DT.91966429 DT.121177108

DT.100033267 DT.100798551 DT.102834158 DT.121177089 DT.92390396 DT.97859668 DT.100798549 DT.92462151

DT.95155996 DT.121177074 DT.87017481

Selected AceView cDNA sequences (see all 532):

AI866938 AI420840 CA449503 CA388841 AI285040 BF718546 AA303809 AA552534

AA576081 BQ676236 AW008984 AA458979 CF130614 AI018297 BF063195 AL709991

BQ222849 AI675890 CB529506 AI192758 AA429612 BQ679641 CR626523 BU162888

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CKAP4 expression in normal human tissues (normalized intensities) CKAP4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGAGGTTTG

About this image

CKAP4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 8) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Eye (Sensory Organs) fully expand to see all 2 entries
Limbal epithelial stem cells (family)

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Pancreas (Endocrine System)
Islets of Langerhans

CKAP4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CKAP4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.74368

Custom PCR Arrays for CKAP4

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CKAP4 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ckap4^{1 , 5}	cytoskeleton-associated protein 4^{1, 5}	84.21(n)¹ 83.67(a)¹		10 (41.52 cM)⁵ 216197¹ NM_175451.1¹ NP_780660.1¹ 84526305⁵
chicken (Gallus gallus)	Aves	CKAP4¹	cytoskeleton-associated protein 4	61.95(n) 57.51(a)		418073 XM_416309.4 XP_416309.4
lizard (Anolis carolinensis)	Reptilia	CKAP4⁶	cytoskeleton-associated protein 4	53(a)	1 ↔ 1	5(19117130-19125880)
African clawed frog (Xenopus laevis)	Amphibia	BG554644.1²	--	81.25(n)		BG554644.1
wheat (Triticum aestivum)	Liliopsida	BQ484045.1²	--	70.93(n)		BQ484045.1

ENSEMBL Gene Tree for CKAP4 (if available)
TreeFam Gene Tree for CKAP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CKAP4 gene

CKAP4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CKAP4
PGOHUM00000233631

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182872619^1,2		--	106484663(+)	`AGGGTA/GTGTTC`	1	--	us2k¹		0	--	--	--	--
rs140063177^1,2	C	--	106631227(+)	`CAGAAA/CCCGGG`	1	--	ds500¹		0	--	--	--	--
rs144093246^1,2	C	--	106631285(+)	`GGTGA-/CA GAGCGCAGAG`	1	--	ds500¹		0	--	--	--	--
rs180925119^1,2		--	106631292(+)	`AGAGCA/GAGACT`	1	--	ds500¹		0	--	--	--	--
rs57612433^1,2	C	--	106631324(+)	`AAAAA-/AAAAAAAA /AAAAAAAAACAGTG`	2	--	ds500¹ cds¹		1		NA	2
rs201240412^1,2	C	--	106631325(-)	`GCACTG/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs11112908^1,2	C,A	--	106631397(+)	`GCTCCT/AAGGAA`	1	--	ds500¹		4		WA NA EA	360
rs143805050^1,2	C	--	106631423(+)	`TGAGGA/GTTGAG`	1	--	ds500¹		0	--	--	--	--
rs117110586^1,2	C,F	--	106631434(+)	`ATCCTG/CTGCTT`	1	--	ds500¹		1		NA	120
rs76047848^1,2		--	106631501(+)	`AAAGGA/TGGTCC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CKAP4 (106631655 - 106698057 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CKAP4: About this table

Variant ID	Type	Subtype	PubMed ID
esv25104	CNV	Loss	19812545

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CKAP4

DNA2.0 Custom Variant and Variant Library Synthesis for CKAP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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20 diseases for CKAP4: About MalaCards

steroid-induced glaucoma chronic interstitial cystitis cystitis n syndrome

split foot amelogenesis imperfecta lynch syndrome bladder carcinoma

glaucoma tonsillitis intrahepatic cholangiocarcinoma cholangiocarcinoma

endotheliitis squamous cell carcinoma melanoma thyroiditis

cerebritis alzheimer's disease neuronitis prostatitis

2 diseases from the University of Copenhagen DISEASES database for CKAP4:

Interstitial cystitis steroid-induced glaucoma

CKAP4 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Export disorders for CKAP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CKAP4 gene, integrated from 10 sources (see all 80):
(articles sorted by number of sources associating them with CKAP4)

Utopia: connect your pdf to the dynamic
world of online information

A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PubMed id 8314870)^{1, 2, 3} Schweizer A....Hauri H.-P. (J. Cell Sci. 1993)
Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PubMed id 19144824)^{1, 2, 9} Planey S.L.... Zacharias D.A. (Mol. Biol. Cell 2009)
Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PubMed id 15703217)^{1, 2, 9} Vedrenne C.... Hauri H.P. (Mol. Biol. Cell 2005)
CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. (PubMed id 17030514)^{1, 2} Conrads T.P.... Keay S.K. (J. Biol. Chem. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment. (PubMed id 11402071)^{1, 9} Klopfenstein D.R....Hauri H.P. (J. Cell Biol. 2001)
Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4). (PubMed id 12913003)^{1, 9} Razzaq T.M....Ellis V. (J. Biol. Chem. 2003)
Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. (PubMed id 17567679)^{2, 9} Nikonov A.V.... Kreibich G. (J. Cell Sci. 2007)
Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells. (PubMed id 23921950)¹ Chen Y....Sen G.L. (J. Invest. Dermatol. 2014)
Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection. (PubMed id 23665508)¹ Li M.H....Wang H.Y. (Cancer Lett. 2013)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10970	HGNC: 16991	AceView: CKAP4	Ensembl:ENSG00000136026	euGenes: HUgn10970
ECgene: CKAP4	Kegg: 10970	H-InvDB: CKAP4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CKAP4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CKAP4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CKAP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CKAP4 gene:
Search GeneIP for patents involving CKAP4

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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CKAP4 Gene

Cytoskeleton-Associated Protein 4

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CKAP4 Gene

Cytoskeleton-Associated Protein 4

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