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CKAP2L Gene

protein-coding   GIFtS: 48
GCID: GC02M113497

Cytoskeleton Associated Protein 2-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytoskeleton Associated Protein 2-Like1 2
Radial Fiber And Mitotic Spindle Protein2 3
Cytoskeleton-Associated Protein 2-Like2
radmis2
Radmis3

External Ids:    HGNC: 268771   Entrez Gene: 1504682   Ensembl: ENSG000001696077   UniProtKB: Q8IYA63   

Export aliases for CKAP2L gene to outside databases

Previous GC identifers: GC02M113211 GC02M105951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CKAP2L Gene:
CKAP2L (cytoskeleton associated protein 2-like) is a protein-coding gene. An important paralog of this gene is CKAP2.

UniProtKB/Swiss-Prot: CKP2L_HUMAN, Q8IYA6
Function: Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in
neural progenitor cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKAP2L gene promoter:
         AREB6   PPAR-alpha   c-Fos   AP-1   Hand1   c-Jun   POU3F2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKAP2L promoter sequence
   Search Chromatin IP Primers for CKAP2L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKAP2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

CKAP2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP2L gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M113497:  view genomic region     (about GC identifiers)

Start:
113,493,930 bp from pter      End:
113,522,254 bp from pter
Size:
28,325 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CKP2L_HUMAN, Q8IYA6 (See protein sequence)
Recommended Name: Cytoskeleton-associated protein 2-like  
Size: 745 amino acids; 83587 Da
Sequence caution: Sequence=AAX93053.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K915 B4DZE3 B7ZAC6 F5H0M5 Q53QF8 Q53RS8 Q8N1J8
Alternative splicing: 3 isoforms:  Q8IYA6-1   Q8IYA6-2   Q8IYA6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CKAP2L: NX_Q8IYA6

Explore proteomics data for CKAP2L at MOPED

Post-translational modifications: 

  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) (By similarity)1
  • Ubiquitination2 at Lys257, Lys582
  • Modification sites at PhosphoSitePlus

  • See CKAP2L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689728.3  
    ENSEMBL proteins: 
     ENSP00000305204   ENSP00000414834   ENSP00000438763  

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    Cloud-Clone Corp. Proteins for CKAP2L

     
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    antibodies-online proteins for CKAP2L (2 products) 

     
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    antibodies-online kits for CKAP2L (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026165 CKAP2_fam

    Graphical View of Domain Structure for InterPro Entry Q8IYA6

    ProtoNet protein and cluster: Q8IYA6

    UniProtKB/Swiss-Prot: CKP2L_HUMAN, Q8IYA6
    Domain: The KEN box is required for the association with the APC/C-Cdh1 complex, ubiquitination and degradation
    (By similarity)
    Similarity: Belongs to the CKAP2 family


    Find genes that share domains with CKAP2L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CKP2L_HUMAN, Q8IYA6
    Function: Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in
    neural progenitor cells (By similarity)

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for CKAP2L

    miRNA
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    miRTarBase miRNAs that target CKAP2L:
    hsa-mir-769-5p (MIRT016097), hsa-mir-196a-5p (MIRT048215), hsa-mir-192-5p (MIRT026525), hsa-mir-215-5p (MIRT024751), hsa-mir-193b-3p (MIRT016509)

    Block miRNA regulation of human, mouse, rat CKAP2L using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CKAP2L:
    hsa-miR-548a-3p hsa-miR-3662 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCKAP2L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CKAP2L

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CKP2L_HUMAN, Q8IYA6: Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Uniformly distributed along each
    microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at
    interphase (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with CKAP2L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CKAP2L
    Interactions:

        Search GeneGlobe Interaction Network for CKAP2L

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKAP2L (CKP2L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CKAP2L gene: 
    NM_152515.3  

    Unigene Cluster for CKAP2L:

    Cytoskeleton associated protein 2-like
    Hs.434250  [show with all ESTs]
    Unigene Representative Sequence: AL832036
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302450(uc002tie.2 uc002tif.2 uc010yxp.1 uc010yxq.1)
    ENST00000435431 ENST00000474331 ENST00000481732 ENST00000461876 ENST00000497357
    ENST00000541405
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CKAP2L:
    hsa-miR-548a-3p hsa-miR-3662 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCKAP2L 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CKAP2L
    Predesigned siRNA for gene silencing in human, mouse, rat CKAP2L
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    OriGene qPCR primer pairs and template standards for CKAP2L
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      QuantiTect SYBR Green Assays in human, mouse, rat CKAP2L
      QuantiFast Probe-based Assays in human, mouse, rat CKAP2L

    Additional mRNA sequence: 

    AK097948.1 AK292530.1 AK302875.1 AK316241.1 AL832036.1 BC036217.1 

    4 DOTS entries:

    DT.100023462  DT.99941600  DT.95100688  DT.95312163 

    Selected AceView cDNA sequences (see all 69):

    AA243534 AI367331 AA485203 BQ420771 BX398234 AA887735 BF969844 AW239184 
    AA814654 N33960 AV756446 CD637874 AA243475 BF699573 NM_152515 AA448645 
    BU171455 BC036217 AA489023 AA448741 BG171588 AA417744 CB128549 AI026756 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                                          
    SP2:              -                             -                                             
    SP3:              -                                                                           
    SP4:              -           -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CKAP2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CKAP2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAAATCT
    CKAP2L Expression
    About this image


    CKAP2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
     
     Brain (Nervous System)
             Choroid Plexus Progenitor Cells Choroid Plexus
    CKAP2L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKAP2L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434250
        Custom PCR Arrays for CKAP2L
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CKAP2L gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckap2l1 , 5 cytoskeleton associated protein 2-like1, 5 75.85(n)1
    64.72(a)1
      2 (62.87 cM)5
    704661  NM_181589.31  NP_853620.11 
     1292682105 
    zebrafish
    (Danio rerio)
    Actinopterygii CKAP2L6
    cytoskeleton associated protein 2-like
    14(a)
    1 ↔ 1
    5(14757982-14768101) ENSDARG00000092098


    ENSEMBL Gene Tree for CKAP2L (if available)
    TreeFam Gene Tree for CKAP2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CKAP2L gene
    CKAP22  

    Find genes that share paralogs with CKAP2L           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CKAP2L
    PGOHUM00000259624


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CKAP2L (see all 678)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123654491,2
    C,F--113494984(+) GTTAAC/TAGCCA 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1882200011,2
    C--113495029(+) TTTAAA/TTTACA 1 -- ds50010--------
    rs793123231,2
    C,F--113495056(+) TGATGC/TTGAGC 1 -- ds50012Minor allele frequency- T:0.50NA 4
    rs780535581,2
    C,F--113495073(+) TCATAC/TACCTA 1 -- ds50012Minor allele frequency- T:0.50NA 4
    rs1156942881,2
    C,F--113495120(+) GTCTGC/TTCAGG 1 -- ds50011Minor allele frequency- T:0.06WA 118
    rs561527541,2
    C,F--113495227(+) TTTGAG/ACTTTA 1 -- ds50014Minor allele frequency- A:0.11WA CSA 123
    rs557121301,2
    C,F--113495316(+) TCAAAG/ATCCAT 1 -- ds50015Minor allele frequency- A:0.12WA CSA 125
    rs1392102001,2
    --113495334(+) GGTAAA/TGAATG 1 -- ds50010--------
    rs102063031,2
    C--113495445(+) CAAGCA/GGGAAC 1 -- ut31 ese30--------
    rs1126800001,2
    C--113495537(+) TACAC-/AATTAT 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for CKAP2L (113493930 - 113522254 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CKAP2L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526301CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CKAP2L
    DNA2.0 Custom Variant and Variant Library Synthesis for CKAP2L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for CKAP2L:
    Aggressive periodontitis

    Find genes that share disorders with CKAP2L           About GenesLikeMe

    Genetic Association Database (GAD): CKAP2L
    Human Genome Epidemiology (HuGE) Navigator: CKAP2L (2 documents)

    Export disorders for CKAP2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CKAP2L gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CKAP2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    2. Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population. (PubMed id 18723088)1, 4 Fiebig A....GrAPssner-Schreiber B. (Genomics 2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)4 McClay J.L....van den Oord E.J. (Neuropsychopharmacology 2011)
    8. Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population. (PubMed id 20844546)4 Adachi S....Tanaka K. (J. Hum. Genet. 2010)
    9. In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. (PubMed id 20388717)2 Blomster H.A.... Sistonen L. (J. Biol. Chem. 2010)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150468 HGNC: 26877 AceView: FLJ40629 Ensembl:ENSG00000169607 euGenes: HUgn150468
    ECgene: CKAP2L H-InvDB: CKAP2L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CKAP2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CKAP2L gene:
    Search GeneIP for patents involving CKAP2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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