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Aliases for CKAP2L Gene

Aliases for CKAP2L Gene

  • Cytoskeleton Associated Protein 2-Like 2 3
  • Radial Fiber And Mitotic Spindle Protein 3 4
  • Radmis 3 4
  • Cytoskeleton-Associated Protein 2-Like 3
  • Radial Fiber And Mitotic Spindle 2

External Ids for CKAP2L Gene

Previous GeneCards Identifiers for CKAP2L Gene

  • GC02M113211
  • GC02M113497
  • GC02M105951

Summaries for CKAP2L Gene

Entrez Gene Summary for CKAP2L Gene

  • The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CKAP2L Gene

CKAP2L (Cytoskeleton Associated Protein 2-Like) is a Protein Coding gene. Diseases associated with CKAP2L include filippi syndrome. An important paralog of this gene is CKAP2.

UniProtKB/Swiss-Prot for CKAP2L Gene

  • Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP2L Gene

Genomics for CKAP2L Gene

Regulatory Elements for CKAP2L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CKAP2L Gene

112,736,607 bp from pter
112,764,677 bp from pter
28,071 bases
Minus strand

Genomic View for CKAP2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKAP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP2L Gene

Proteins for CKAP2L Gene

  • Protein details for CKAP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoskeleton-associated protein 2-like
    Protein Accession:
    Secondary Accessions:
    • A8K915
    • B4DZE3
    • B7ZAC6
    • F5H0M5
    • Q53QF8
    • Q53RS8
    • Q8N1J8

    Protein attributes for CKAP2L Gene

    745 amino acids
    Molecular mass:
    83587 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAX93053.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CKAP2L Gene


neXtProt entry for CKAP2L Gene

Proteomics data for CKAP2L Gene at MOPED

Post-translational modifications for CKAP2L Gene

  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C).
  • Ubiquitination at Lys257 and Lys582
  • Modification sites at PhosphoSitePlus

Other Protein References for CKAP2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CKAP2L Gene

Domains for CKAP2L Gene

Protein Domains for CKAP2L Gene


Suggested Antigen Peptide Sequences for CKAP2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The KEN box is required for the association with the APC/C-Cdh1 complex, ubiquitination and degradation.
  • Belongs to the CKAP2 family.
  • The KEN box is required for the association with the APC/C-Cdh1 complex, ubiquitination and degradation.
  • Belongs to the CKAP2 family.
genes like me logo Genes that share domains with CKAP2L: view

No data available for Gene Families for CKAP2L Gene

Function for CKAP2L Gene

Molecular function for CKAP2L Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.
UniProtKB/Swiss-Prot Induction:
Expression is cell-cycle dependent. Undetectable in interphase and prophase, strong expression at the spindle pole throughout metaphase to telophase.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKAP2L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CKAP2L Gene

Localization for CKAP2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP2L Gene

Cytoplasm, cytoskeleton, spindle pole. Note=Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase. {ECO:0000269 PubMed:25439729}.

Subcellular locations from

Jensen Localization Image for CKAP2L Gene COMPARTMENTS Subcellular localization image for CKAP2L gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CKAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with CKAP2L: view

Pathways for CKAP2L Gene

SuperPathways for CKAP2L Gene

No Data Available

Interacting Proteins for CKAP2L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000305204 for CKAP2L Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CKAP2L Gene


No data available for Pathways by source for CKAP2L Gene

Transcripts for CKAP2L Gene

Unigene Clusters for CKAP2L Gene

Cytoskeleton associated protein 2-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKAP2L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
SP2: - -
SP3: -
SP4: - -

Relevant External Links for CKAP2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CKAP2L Gene

mRNA expression in normal human tissues for CKAP2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKAP2L Gene

This gene is overexpressed in Testis (5.6) and Esophagus - Mucosa (4.2).

Protein differential expression in normal tissues for CKAP2L Gene

This gene is overexpressed in Spleen (57.2) and Testis (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKAP2L Gene

SOURCE GeneReport for Unigene cluster for CKAP2L Gene Hs.434250

genes like me logo Genes that share expressions with CKAP2L: view

Expression partners for CKAP2L Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CKAP2L Gene

Orthologs for CKAP2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP2L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CKAP2L 35
  • 82.65 (n)
  • 74.59 (a)
  • 73 (a)
(Canis familiaris)
Mammalia CKAP2L 35
  • 84.46 (n)
  • 76.08 (a)
  • 75 (a)
(Mus musculus)
Mammalia Ckap2l 35
  • 75.85 (n)
  • 64.72 (a)
Ckap2l 16
Ckap2l 36
  • 61 (a)
(Pan troglodytes)
Mammalia CKAP2L 35
  • 99.24 (n)
  • 98.52 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ckap2l 35
  • 75.67 (n)
  • 63.5 (a)
(Ornithorhynchus anatinus)
Mammalia CKAP2L 36
  • 29 (a)
(Danio rerio)
Actinopterygii CKAP2L 36
  • 14 (a)
Species with no ortholog for CKAP2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CKAP2L Gene

Gene Tree for CKAP2L (if available)
Gene Tree for CKAP2L (if available)

Paralogs for CKAP2L Gene

Paralogs for CKAP2L Gene Pseudogenes for CKAP2L Gene

genes like me logo Genes that share paralogs with CKAP2L: view

Variants for CKAP2L Gene

Sequence variations from dbSNP and Humsavar for CKAP2L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1040191 -- 112,751,881(-) TTTCT(A/G)TGTAA intron-variant
rs1040192 -- 112,765,410(+) gccat(A/G)taagt upstream-variant-2KB
rs1052529 -- 112,738,554(-) ATTTA(A/T)ACTTT utr-variant-3-prime
rs2048874 -- 112,766,390(+) CCACG(C/T)AGTGC upstream-variant-2KB
rs2676122 -- 112,738,057(+) CACTG(C/G)CTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CKAP2L Gene

Variant ID Type Subtype PubMed ID
nsv526301 CNV Loss 19592680

Relevant External Links for CKAP2L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP2L Gene

Disorders for CKAP2L Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CKAP2L Gene in MalaCards »

(1) Disease for CKAP2L Gene


  • Filippi syndrome (FLPIS) [MIM:272440]: A rare disorder characterized by microcephaly, pre- and postnatal growth failure, syndactyly, and distinctive facial features, including a broad nasal bridge and underdeveloped alae nasi. Some affected individuals have intellectual disability, seizures, undescended testicles in males, and teeth and hair abnormalities. {ECO:0000269 PubMed:25439729}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CKAP2L Gene

Relevant External Links for CKAP2L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CKAP2L: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for CKAP2L Gene

Publications for CKAP2L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population. (PMID: 18723088) Fiebig A. … GrAPssner-Schreiber B. (Genomics 2008) 3 48
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  4. Mutations in CKAP2L, the human homolog of the mouse Radmis gene, cause Filippi syndrome. (PMID: 25439729) Hussain M.S. … NA1rnberg P. (Am. J. Hum. Genet. 2014) 3 4
  5. Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors. (PMID: 24260314) Yumoto T. … Sakakibara S. (PLoS ONE 2013) 2 3

Products for CKAP2L Gene

Sources for CKAP2L Gene

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