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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CKAP2L Gene

protein-coding GIFtS: 43
GCID: GC02M113497

cytoskeleton associated protein 2-like

Explore 3 diseases affiliated with
CKAP2L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytoskeleton Associated Protein 2-Like¹ ²
FLJ40629¹
Cytoskeleton-Associated Protein 2-Like²

External Ids:	HGNC: 26877¹	Entrez Gene: 150468²	Ensembl: ENSG00000169607⁷	UniProtKB: Q8IYA6³

Export aliases for CKAP2L gene to outside databases

Previous GC identifers: GC02M113211 GC02M105951

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CKAP2L gene promoter:
AREB6 PPAR-alpha c-Fos AP-1 Hand1 c-Jun POU3F2 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKAP2L promoter sequence

Search SABiosciences Chromatin IP Primers for CKAP2L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKAP2L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13

CKAP2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP2L gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M113497: view genomic region (about GC identifiers)

Start:	113,493,930 bp from pter	End:	113,522,254 bp from pter
Size:	28,325 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CKP2L_HUMAN, Q8IYA6 (See protein sequence)

Recommended Name: Cytoskeleton-associated protein 2-like

Size: 745 amino acids; 83587 Da

Sequence caution: Sequence=AAX93053.1; Type=Erroneous gene model prediction;

Secondary accessions: A8K915 Q53QF8 Q53RS8 Q8N1J8

Alternative splicing: 2 isoforms: Q8IYA6-1 Q8IYA6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CKAP2L: NX_Q8IYA6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IYA6

CKAP2L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689728.3

ENSEMBL proteins:

ENSP00000305204 ENSP00000414834 ENSP00000438763

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	Uscn Proteins for CKAP2L

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005813	centrosome	IDA	--

CKAP2L for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CKAP2L for domains About GeneDecksing

2 InterPro domains/families:

IPR026165 CKAP2_fam

IPR026167 CKAP2-like

Graphical View of Domain Structure for InterPro Entry Q8IYA6

ProtoNet protein and cluster: Q8IYA6

UniProtKB/Swiss-Prot: CKP2L_HUMAN, Q8IYA6

Similarity: Belongs to the CKAP2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CKAP2L

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CKAP2L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CKAP2L gene:

NM_152515.3

Unigene Cluster for CKAP2L:

Cytoskeleton associated protein 2-like

Hs.434250 [show with all ESTs]

Unigene Representative Sequence: AL832036

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302450(uc002tie.2 uc002tif.2 uc010yxp.1 uc010yxq.1)

ENST00000435431 ENST00000474331 ENST00000481732 ENST00000461876 ENST00000497357

ENST00000541405

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Additional cDNA sequence:

AK097948.1 AK292530.1 AK302875.1 AK316241.1 AL832036.1 BC036217.1

4 DOTS entries:

DT.100023462 DT.99941600 DT.95100688 DT.95312163

24/69 AceView cDNA sequences (see all 69):

BX398234 AA243534 BF969844 AI367331 AW239184 AA814654 AA485203 BQ420771

AA887735 CB128549 BG505084 AV756446 AA243475 CB117127 CA433096 BG034585

AA417744 BX422230 BQ427427 CD637874 BI868845 AA768032 AA448741 BG613293

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2L About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10
SP1:
SP2:					-										-
SP3:					-
SP4:					-				-
SP5:

ECgene alternative splicing isoforms for CKAP2L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CKAP2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTAAATCT

About this image

CKAP2L expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See CKAP2L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CKAP2L

SOURCE GeneReport for Unigene cluster: Hs.434250

SABiosciences Custom PCR Arrays for CKAP2L

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CKAP2L gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100858544¹	cytoskeleton-associated protein 2-like	51.64(n) 44.79(a)		100858544 XM_003643237.1 XP_003643285.1
zebrafish (Danio rerio)	Actinopterygii	si:ch211-255a21.1¹	si:ch211-255a21.1	43.93(n) 30.42(a)		569937 NM_001126431.1 NP_001119903.1

ENSEMBL Gene Tree for CKAP2L (if available)
TreeFam Gene Tree for CKAP2L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CKAP2L gene

CKAP2²

CKAP2L for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CKAP2L
PGOHUM00000259624

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112365449^1,2	C	--	105949562(+)	`GTTAAC/TAGCCA`	1	--	int¹		1		NA	2
rs79312323^1,2	C,F	--	105949634(+)	`TGATGC/TTGAGC`	1	--	int¹		2		NA	4
rs78053558^1,2	C,F	--	105949651(+)	`TCATAC/TACCTA`	1	--	int¹		2		NA	4
rs56152754^1,2	C,F	--	105949805(+)	`TTTGAG/ACTTTA`	1	--	int¹		4		WA CSA	123
rs55712130^1,2	C,F	--	105949894(+)	`TCAAAG/ATCCAT`	1	--	int¹		5		WA CSA	125
rs10206303^1,2	C	--	105950023(+)	`CAAGCA/GGGAAC`	1	--	int¹ ese³		0	--	--	--	--
rs112680000^1,2	C	--	105950115(+)	`TACAC-/AATTAT`	1	--	int¹		1		CSA	2
rs2676122^1,2	H	--	105950212(+)	`CACTGC/GCTTCT`	1	--	int¹		1		NS	120
rs1052529^1,2	C,F	--	105950709(-)	`ATTTAT/AACTTT`	1	--	int¹		7		MN WA NA CSA	314
rs6756392^1,2	C	--	105950764(+)	`TGTATA/GCTGTA`	1	--	int¹ ese³		2		WA	120

HapMap Linkage Disequilibrium report for CKAP2L (113493930 - 113522254 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CKAP2L: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CKAP2L for disorders About GeneDecksing

3 diseases for CKAP2L: About MalaCards

aggressive periodontitis conduct disorder periodontitis

1 disease from the University of Copenhagen DISEASES database for CKAP2L:

Aggressive periodontitis

Human Genome Epidemiology (HuGE) Navigator: CKAP2L (2 documents)

Export disorders for CKAP2L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CKAP2L gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CKAP2L)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. (PubMed id 20388717)² Blomster H.A.... Sistonen L. (2010)
Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)¹ Dick D.M....Bierut L. (2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population. (PubMed id 18723088)¹ Fiebig A....Grossner-Schreiber B. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 150468	HGNC: 26877	AceView: FLJ40629	Ensembl:ENSG00000169607	euGenes: HUgn150468
ECgene: CKAP2L	H-InvDB: CKAP2L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CKAP2L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CKAP2L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CKAP2L gene:
Search GeneIP for patents involving CKAP2L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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	GenScript Custom Purified and Recombinant Proteins Services for CKAP2L		GenScript cDNA clones with any tag delivered in your preferred vector for CKAP2L
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CKAP2L

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CKAP2L

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CKAP2L gene at Home site.

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CKAP2L Gene

cytoskeleton associated protein 2-like

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Export list of displayed genes

CKAP2L Gene

cytoskeleton associated protein 2-like

Aliasesfor CKAP2L gene

Summariesfor CKAP2L gene

Genomic Viewsfor CKAP2L gene

Proteinsfor CKAP2L gene

Protein Domains /Familiesfor CKAP2L gene

Functionfor CKAP2L gene

Pathways & Interactionsfor CKAP2L gene

Drugs & Compoundsfor CKAP2L gene

Transcriptsfor CKAP2L gene

Expression for CKAP2L gene

Orthologsfor CKAP2L gene

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Genomic Variantsfor CKAP2L gene

Disorders / Diseasesfor CKAP2L gene

Publicationsfor CKAP2L gene

External Searches for CKAP2L gene

Genome Databases showing CKAP2L gene

Other Databases showing CKAP2L gene

Specialized Databases showing CKAP2L gene

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Productsfor CKAP2L gene

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Aliases
for CKAP2L gene

Summaries
for CKAP2L gene

Genomic Views
for CKAP2L gene

Proteins
for CKAP2L gene

Protein Domains /
Families
for CKAP2L gene

Function
for CKAP2L gene

Pathways & Interactions
for CKAP2L gene

Drugs & Compounds
for CKAP2L gene

Transcripts
for CKAP2L gene

Expression
for CKAP2L gene

Orthologs
for CKAP2L gene

Paralogs
for CKAP2L gene

Genomic Variants
for CKAP2L gene

Disorders / Diseases
for CKAP2L gene

Publications
for CKAP2L gene

Intellectual Property
for CKAP2L gene

Products
for CKAP2L gene