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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CKAP2 Gene

protein-coding GIFtS: 48
GCID: GC13P053029

cytoskeleton associated protein 2

Explore 15 diseases affiliated with
CKAP2 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytoskeleton Associated Protein 2¹ ²		CTCL Tumor Antigen Se20-10² ³
LB1¹ ² ³ ⁵		FLJ10749¹
TMAP¹ ² ³ ⁵		Cytoskeleton-Associated Protein 2²
Se20-10¹		Tumor-Associated Microtubule-Associated Protein²
Tumor- And Microtubule-Associated Protein² ³

External Ids:	HGNC: 1990¹	Entrez Gene: 26586²	Ensembl: ENSG00000136108⁷	OMIM: 611569⁵	UniProtKB: Q8WWK9³

Export aliases for CKAP2 gene to outside databases

Previous GC identifers: GC13P050997 GC13P047024 GC13P051966 GC13P050827 GC13P051927 GC13P033768

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKAP2:

CKAP2 is a cytoskeleton-associated protein involved in mitotic progression (Seki and Fang, 2007 (PubMed

17376772)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9

Function: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death

in a p53/TP53-dependent manner (By similarity)

Gene Wiki entry for CKAP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CKAP2 gene promoter:
NF-YA CBF-C PPAR-alpha NF-YB CBF-B CBF-A CP1A CP1C NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CKAP2 promoter sequence

Search SABiosciences Chromatin IP Primers for CKAP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CKAP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14

CKAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP2 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P053029: view genomic region (about GC identifiers)

Start:	53,029,495 bp from pter	End:	53,050,763 bp from pter
Size:	21,269 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9 (See protein sequence)

Recommended Name: Cytoskeleton-associated protein 2

Size: 683 amino acids; 76987 Da

Subunit: Associates with alpha- and beta-tubulins (By similarity)

Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.

Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S

and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and

centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and

spindle microtubules. During cytokinesis, absent from midbody microtubules

Developmental stage: Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly

degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C)

Sequence caution: Sequence=AAG33675.1; Type=Frameshift; Positions=607; Sequence=AAH10901.1; Type=Erroneous initiation;

Sequence=AAI05807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=BAA91788.1; Type=Erroneous initiation;

Secondary accessions: A2BDE0 A5YM58 Q3KRA5 Q5VXB4 Q8IWV5 Q8IWV6 Q96FH9 Q9H012 Q9H0D0 Q9H988 Q9HC49

Q9NVG4

Alternative splicing: 3 isoforms: Q8WWK9-1 Q8WWK9-2 Q8WWK9-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CKAP2: NX_Q8WWK9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WWK9

CKAP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001091995.1 NP_060674.3

ENSEMBL proteins:

ENSP00000418431 ENSP00000367273 ENSP00000258607 ENSP00000367276 ENSP00000417830

ENSP00000418224

Human Recombinant Protein Products for CKAP2:

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	Uscn Proteins for CKAP2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005881	cytoplasmic microtubule	IDA	16061649
GO:0015630	microtubule cytoskeleton	IDA	--

CKAP2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CKAP2 for domains About GeneDecksing

2 InterPro domains/families:

IPR026166 CKAP2

IPR026165 CKAP2_fam

Graphical View of Domain Structure for InterPro Entry Q8WWK9

ProtoNet protein and cluster: Q8WWK9

UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9

Similarity: Belongs to the CKAP2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CKAP2_HUMAN, Q8WWK9

Function: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death

in a p53/TP53-dependent manner (By similarity)

Induction: Up-regulated in primary human gastric cancers

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CKAP2

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		hsa-miR-203 hsa-miR-607 hsa-miR-653 hsa-miR-3613-3p hsa-miR-3121-3p
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CKAP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for CKAP2 (Q8WWK9³ ENSP00000367276⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAG	P61981³, ENSP00000306330⁴	I2D: score=1 STRING: ENSP00000306330
IGHA1	P01876³, ENSP00000374989⁴	I2D: score=1 STRING: ENSP00000374989
ARL3	ENSP00000260746⁴	STRING: ENSP00000260746
BIRC5	ENSP00000301633⁴	STRING: ENSP00000301633
PAFAH1B1	ENSP00000380378⁴	STRING: ENSP00000380378

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000281	cytokinesis after mitosis	IGI	16061649
GO:0006915	apoptotic process	IEA	--
GO:0007026	negative regulation of microtubule depolymerization	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IGI	16061649

CKAP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CKAP2
Search CenterWatch for drugs/clinical trials and news about CKAP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CKAP2 gene (2 alternative transcripts):

NM_001098525.1 NM_018204.3

Unigene Clusters for CKAP2:

Cytoskeleton associated protein 2

Hs.444028 [show with all ESTs], Hs.625768 [show with all ESTs]

Unigene Representative Sequences: NM_001098525, AK025231

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000468284 ENST00000378034(uc001vgt.2) ENST00000258607(uc001vgu.2 uc001vgv.2)

ENST00000378037 ENST00000490903(uc010tha.1) ENST00000480747 ENST00000459902

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Additional cDNA sequence:

AB027448.1 AB063993.1 AB064011.1 AB064145.1 AB064152.1 AB064153.1 AB064156.1 AB064158.1

AB064160.1 AB064161.1 AB064163.1 AB064164.1 AB064168.1 AB064173.1 AB064174.1 AB064175.1

AB064176.1 AB064186.1 AB064189.1 AB064202.1 AB064207.1 AB064212.1 AB064215.1 AB064220.1

AB064233.1 AB363348.1 AB363366.1 AB369252.1 AF001788.1 AF021038.1 AF029338.1 AF047205.1

AF047218.1 AF047219.1 AF047224.1 AF047227.1 AF047228.1 AF047236.1 AF051809.1 AF052760.1

AF052761.1 AF052776.1 AF052778.1 AF052794.1 AF052796.1 AF052798.1 AF052803.1 AF052824.1

AF058061.1 AF060139.1 AF060141.1 AF060143.1 AF060146.1 AF063708.1 AF063710.1 AF063713.1

AF063734.1 AF063744.1 AF063758.1 AF063762.1 AF063779.1 AF064496.1 AF064508.1 AF064509.1

AF064511.1 AF090353.1 AF092503.1 AF103616.1 AF103644.1 AF103645.1 AF103647.1 AF103658.1

AF103693.1 AF103697.1 AF103698.1 AF103701.1 AF103722.1 AF107250.1 AF124173.1 AF194540.1

AF194541.1 AF194545.1 AF194546.1 AF194549.1 AF194551.1 AF194553.1 AF194569.1 AF194594.1

AF194596.1 AF194597.1 AF194606.1 AF194642.1 AF194647.1 AF194650.1 AF194652.1 AF194653.1

AF194654.1 AF194656.1 AF211205.1 AF336988.1 AF462660.1 AF462675.1 AJ001168.1 AJ010336.1

AJ132426.1 AJ233715.1 AJ233730.1 AJ241414.1 AJ243109.1 AJ293742.1 AJ318021.1 AJ318022.1

AJ319670.1 AJ399843.1 AJ399866.1 AJ408271.1 AJ408281.1 AJ408285.1 AJ410920.1 AJ496494.1

AK025231.1 AK130415.1 AM181371.1 AY043151.1 AY050712.1 AY062361.1 AY423262.1 AY423264.1

AY423265.1 AY485364.1 AY530323.1 AY530325.1 AY577307.1 AY685383.1 AY749163.1 AY749164.1

AY942003.1 AY942006.1 AY942038.1 AY942053.1 AY942076.1 AY962389.1 BC012876.2 BC070352.1

BC070353.1 BC073784.1 BC073786.1 BC073795.1 BC075843.1 CR936629.1 D84143.1 DQ187524.1

DQ205167.1 DQ240234.1 DQ322744.1 DQ322800.1 DQ322868.1 DQ322932.1 DQ322933.1 DQ322980.1

DQ322983.1 DQ322984.1 DQ322992.1 DQ323020.1 EF028219.1 EF589388.1 EF589427.1 EF589432.1

EF589434.1 EF589446.1 EF589457.1 EF589463.1 EF589482.1 EF589494.1 EF589507.1 EF589519.1

EF589529.1 EF589538.1 EF589540.1 EF589543.1 EF589544.1 EF589568.1 EF589571.1 EF710785.1

EF710911.1 EF710912.1 EF710913.1 EF710999.1 EF711087.1 EF711088.1 EF711089.1 EU599331.1

EU599353.1 FJ385450.1 FJ385513.1 FJ385564.1 GU086862.1 HM996166.1 HM996388.1 HQ172110.1

HQ172113.1 HQ172125.1 HQ172135.1 HQ172138.1 HQ172147.1 HQ890348.1 HQ890349.1 JF740068.1

JF740075.1 JF806285.1 JF806287.1 JN130395.1 JQ301915.1 JX027461.1 L03626.1 L03627.1

L29156.1 L29157.1 L29163.1 L38428.1 M80916.1 S67985.1 S67988.1 S76132.1

U07992.1 U09882.1 U09888.1 U09892.1 U09901.1 U86807.1 U87151.1 U95249.1

X57802.1 X57805.1 X57819.1 X87894.1 X99991.1 Y16715.1 Z18847.1 Z46314.1

Z46627.1

24/259 DOTS entries (see all 259):

DT.114665 DT.91962204 DT.431254 DT.120678090 DT.120677661 DT.87079052 DT.95244980 DT.40267692

DT.100885122 DT.100046628 DT.100035257 DT.91934757 DT.86992822 DT.411116 DT.91845681 DT.100885115

DT.86998433 DT.91832774 DT.95068785 DT.95215487 DT.120677346 DT.86855867 DT.87002873 DT.91753654

24/199 AceView cDNA sequences (see all 199):

BX353838 AL043361 BU631631 AL597509 CA418142 AA504389 CR590367 AA954666

BP358498 BF626664 BM451257 BQ433740 AI499799 AY062262 AA436944 AA748686

CR591745 BM456954 BE350644 BU178846 CR607908 CA430297 CB136922 T06386

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10
SP1:																					-
SP2:
SP3:
SP4:									-
SP5:

ECgene alternative splicing isoforms for CKAP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CKAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTAGAGAG

About this image

CKAP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CKAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CKAP2

SOURCE GeneReport for Unigene clusters: Hs.444028 Hs.625768

UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9

Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver,

prostate, and kidney

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CKAP2 gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ckap2^{1 , 5}	cytoskeleton associated protein 2^{1, 5}	75.9(n)¹ 64.32(a)¹		8 (11.13 cM)⁵ 80986¹ NM_001004140.2¹ NP_001004140.2¹ 22168152⁵
chicken (Gallus gallus)	Aves	CKAP2¹	cytoskeleton associated protein 2	52.79(n) 36.66(a)		418882 NM_001006274.1 NP_001006274.1
lizard (Anolis carolinensis)	Reptilia	CKAP2⁶	--	35(a)	1 ↔ 1	1(132720180-132736145)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.6556²	Transcribed sequence with weak similarity to protein more	72.55(n)		AL891731.2
zebrafish (Danio rerio)	Actinopterygii	si:ch211-266i6.3¹	si:ch211-266i6.3	44.81(n) 31.72(a)		568826 XM_692182.4 XP_697274.2

ENSEMBL Gene Tree for CKAP2 (if available)
TreeFam Gene Tree for CKAP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CKAP2 gene

CKAP2L²

CKAP2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CKAP2
PGOHUM00000247733

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115835295^1,2	C,F	--	53027524(+)	`TCCCCA/GGACTT`	2	--	us2k¹		1		WA	118
rs141204178^1,2		--	53027605(+)	`TTACCG/TTCTTC`	2	--	us2k¹		0	--	--	--	--
rs191396509^1,2		--	53027801(+)	`TAATAC/TTAAAA`	2	--	us2k¹		0	--	--	--	--
rs116177661^1,2	F	--	53027805(+)	`ATTAAA/GAAGTG`	2	--	us2k¹		1		WA	118
rs150757210^1,2		--	53027821(+)	`AAAATA/GGACAT`	2	--	us2k¹		0	--	--	--	--
rs139087237^1,2		--	53027903(+)	`TTTCCC/TATTCA`	2	--	us2k¹		0	--	--	--	--
rs183204559^1,2		--	53027965(+)	`ACCATG/TCCCAC`	2	--	us2k¹		0	--	--	--	--
rs144006983^1,2		--	53028064(+)	`CCAACC/TACTAC`	2	--	us2k¹		0	--	--	--	--
rs145932703^1,2		--	53028349(+)	`CCCACC/TTGTCT`	2	--	us2k¹		0	--	--	--	--
rs186016899^1,2		--	53028373(+)	`TAAATA/GATCAA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CKAP2 (53029495 - 53050763 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CKAP2
2 Indels: 25267 101744
1 Inversion: 37145

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CKAP2 for disorders           About GeneDecksing

OMIM gene information: 611569    OMIM disorders: --

15 diseases for CKAP2:    About MalaCards

diffuse large b-cell lymphoma inhalation anthrax b-cell lymphomas otitis media

frey syndrome inclusion conjunctivitis congenital hypothyroidism cutaneous t cell lymphoma

conjunctivitis microcephaly gastric adenocarcinoma hypothyroidism

gastric cancer adenocarcinoma prostatitis

3 diseases from the University of Copenhagen DISEASES database for CKAP2:

Microcephaly Inclusion conjunctivitis Otitis media

Export disorders for CKAP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CKAP2 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with CKAP2)

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Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B-cell lymphomas. (PubMed id 9771967)^{1, 2, 3} Maouche-Chretien L.... Leroy-Viard K. (1998)
CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit. (PubMed id 17376772)^{1, 2} Seki A. and Fang G. (2007)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas. (PubMed id 12942315)^{1, 2} Bae C.-D.... Park J. (2003)
Evolutionarily-conserved gene CKAP2,located in region 13q14.3 of the human genome, is frequently rearranged in various tumors. (PubMed id 11234418)^{1, 2} Udina I.G.... Sulimova G.E. (2001)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)^{1, 2} Eichmueller S....Schadendorf D. (2001)
[The structure of the human oncogenesis-associated CKAP2 (LB1) gene] (PubMed id 12500535)^{1, 9} Rakhmanaliev E.R....Sulimova G.E. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26586	HGNC: 1990	AceView: CKAP2	Ensembl:ENSG00000136108	euGenes: HUgn26586
ECgene: CKAP2	H-InvDB: CKAP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CKAP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CKAP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CKAP2 gene:
Search GeneIP for patents involving CKAP2

GeneCards and IP:
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cytoskeleton associated protein 2

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cytoskeleton associated protein 2

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