Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CKAP2 Gene

Aliases for CKAP2 Gene

  • Cytoskeleton Associated Protein 2 2 3
  • TMAP 3 4 6
  • LB1 3 4 6
  • Tumor- And Microtubule-Associated Protein 3 4
  • CTCL Tumor Antigen Se20-10 3 4
  • Tumor-Associated Microtubule-Associated Protein 3
  • Cytoskeleton-Associated Protein 2 3
  • Se20-10 3

External Ids for CKAP2 Gene

Previous GeneCards Identifiers for CKAP2 Gene

  • GC13P050997
  • GC13P047024
  • GC13P051966
  • GC13P050827
  • GC13P051927
  • GC13P053029
  • GC13P033768

Summaries for CKAP2 Gene

Entrez Gene Summary for CKAP2 Gene

  • This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]

GeneCards Summary for CKAP2 Gene

CKAP2 (Cytoskeleton Associated Protein 2) is a Protein Coding gene. Diseases associated with CKAP2 include inclusion conjunctivitis. An important paralog of this gene is CKAP2L.

UniProtKB/Swiss-Prot for CKAP2 Gene

  • Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).

Gene Wiki entry for CKAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP2 Gene

Genomics for CKAP2 Gene

Regulatory Elements for CKAP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CKAP2 Gene

Start:
52,455,360 bp from pter
End:
52,476,631 bp from pter
Size:
21,272 bases
Orientation:
Plus strand

Genomic View for CKAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP2 Gene

Proteins for CKAP2 Gene

  • Protein details for CKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWK9-CKAP2_HUMAN
    Recommended name:
    Cytoskeleton-associated protein 2
    Protein Accession:
    Q8WWK9
    Secondary Accessions:
    • A2BDE0
    • A5YM58
    • B4DR35
    • E9PD90
    • Q3KRA5
    • Q5VXB4
    • Q8IWV5
    • Q8IWV6
    • Q96FH9
    • Q9H012
    • Q9H0D0
    • Q9H988
    • Q9HC49
    • Q9NVG4

    Protein attributes for CKAP2 Gene

    Size:
    683 amino acids
    Molecular mass:
    76987 Da
    Quaternary structure:
    • Associates with alpha- and beta-tubulins.
    SequenceCaution:
    • Sequence=AAG33675.1; Type=Frameshift; Positions=604; Evidence={ECO:0000305}; Sequence=AAG33675.1; Type=Frameshift; Positions=607; Evidence={ECO:0000305}; Sequence=AAH10901.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI05807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91788.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CKAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKAP2 Gene

Proteomics data for CKAP2 Gene at MOPED

Post-translational modifications for CKAP2 Gene

  • Ubiquitination at Lys70, Lys617, and Lys620
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CKAP2 Gene

Domains for CKAP2 Gene

Protein Domains for CKAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CKAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWK9

UniProtKB/Swiss-Prot:

CKAP2_HUMAN :
  • Q8WWK9
Family:
  • Belongs to the CKAP2 family.
genes like me logo Genes that share domains with CKAP2: view

No data available for Gene Families for CKAP2 Gene

Function for CKAP2 Gene

Molecular function for CKAP2 Gene

UniProtKB/Swiss-Prot Function: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated in primary human gastric cancers.

Animal Model Products

CRISPR Products

miRNA for CKAP2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CKAP2 Gene

Localization for CKAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKAP2 Gene COMPARTMENTS Subcellular localization image for CKAP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005881 colocalizes_with cytoplasmic microtubule IDA 16061649
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with CKAP2: view

Pathways for CKAP2 Gene

SuperPathways for CKAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IGI 16061649
GO:0006915 apoptotic process IEA --
GO:0007026 negative regulation of microtubule depolymerization IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IGI 16061649
genes like me logo Genes that share ontologies with CKAP2: view

No data available for Pathways by source for CKAP2 Gene

Transcripts for CKAP2 Gene

Unigene Clusters for CKAP2 Gene

Cytoskeleton associated protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CKAP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for CKAP2 Gene

GeneLoc Exon Structure for
CKAP2
ECgene alternative splicing isoforms for
CKAP2

Expression for CKAP2 Gene

mRNA expression in normal human tissues for CKAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKAP2 Gene

SOURCE GeneReport for Unigene cluster for CKAP2 Gene Hs.444028

mRNA Expression by UniProt/SwissProt for CKAP2 Gene

Q8WWK9-CKAP2_HUMAN
Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
genes like me logo Genes that share expressions with CKAP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CKAP2 Gene

Orthologs for CKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKAP2 35
  • 98.98 (n)
  • 97.95 (a)
CKAP2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CKAP2 35
  • 79.3 (n)
  • 70.65 (a)
CKAP2 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKAP2 35
  • 81.18 (n)
  • 71.17 (a)
CKAP2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ckap2 35
  • 75.18 (n)
  • 64.42 (a)
Ckap2 16
Ckap2 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ckap2 35
  • 74.41 (n)
  • 63.78 (a)
chicken
(Gallus gallus)
Aves CKAP2 35
  • 54.46 (n)
  • 37.6 (a)
CKAP2 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CKAP2 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap2 35
  • 51.26 (n)
  • 36.71 (a)
Str.6556 35
zebrafish
(Danio rerio)
Actinopterygii CKAP2 36
  • 24 (a)
OneToOne
si:ch211-266i6.3 35
  • 46.51 (n)
  • 33.95 (a)
Species with no ortholog for CKAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CKAP2 Gene

ENSEMBL:
Gene Tree for CKAP2 (if available)
TreeFam:
Gene Tree for CKAP2 (if available)

Paralogs for CKAP2 Gene

Paralogs for CKAP2 Gene

Pseudogenes.org Pseudogenes for CKAP2 Gene

genes like me logo Genes that share paralogs with CKAP2: view

Variants for CKAP2 Gene

Sequence variations from dbSNP and Humsavar for CKAP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs9379 -- 52,476,344(-) AATTA(C/T)ACAGA utr-variant-3-prime
rs1053245 -- 52,455,200(-) TTGAG(A/T)CCCTC upstream-variant-2KB
rs3803262 -- 52,462,263(-) TTACT(C/G/T)TAATG intron-variant
rs3809374 -- 52,461,825(-) TCCAT(C/T)AGTTT synonymous-codon, reference
rs3892337 -- 52,455,350(-) TGTCT(C/G)CCCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CKAP2 Gene

Variant ID Type Subtype PubMed ID
nsv428288 CNV Loss 18775914
nsv900084 CNV Gain 21882294
nsv7242 OTHER Inversion 18451855
dgv1588n71 CNV Loss 21882294
esv2423190 CNV Insertion 19546169
esv1661627 CNV Deletion 17803354

Relevant External Links for CKAP2 Gene

HapMap Linkage Disequilibrium report
CKAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP2 Gene

Disorders for CKAP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CKAP2 Gene including...

Search for CKAP2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for CKAP2 Gene

genes like me logo Genes that share disorders with CKAP2: view

No data available for UniProtKB/Swiss-Prot for CKAP2 Gene

Publications for CKAP2 Gene

  1. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B-cell lymphomas. (PMID: 9771967) Maouche-Chretien L. … Leroy-Viard K. (Oncogene 1998) 2 3 4
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Evolutionarily-conserved gene CKAP2,located in region 13q14.3 of the human genome, is frequently rearranged in various tumors. (PMID: 11234418) Udina I.G. … Sulimova G.E. (Genetika 2001) 3 4
  5. [The structure of the human oncogenesis-associated CKAP2 (LB1) gene]. (PMID: 12500535) Rakhmanaliev E.R. … Sulimova G.E. (Mol. Biol. (Mosk.) 2002) 3 23

Products for CKAP2 Gene

Sources for CKAP2 Gene

Back to Top

Content