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CKAP2 Gene

protein-coding   GIFtS: 50
GCID: GC13P053029

Cytoskeleton Associated Protein 2

  See CKAP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytoskeleton Associated Protein 21 2     CTCL Tumor Antigen Se20-102 3
LB12 3 5     Cytoskeleton-Associated Protein 22
TMAP2 3 5     se20-102
Tumor- And Microtubule-Associated Protein2 3     Tumor-Associated Microtubule-Associated Protein2

External Ids:    HGNC: 19901   Entrez Gene: 265862   Ensembl: ENSG000001361087   OMIM: 6115695   UniProtKB: Q8WWK93   

Export aliases for CKAP2 gene to outside databases

Previous GC identifers: GC13P050997 GC13P047024 GC13P051966 GC13P050827 GC13P051927 GC13P033768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CKAP2 Gene:
This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the
regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine
and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in
multiple transcript variations. (provided by RefSeq, Nov 2013)

GeneCards Summary for CKAP2 Gene:
CKAP2 (cytoskeleton associated protein 2) is a protein-coding gene. Diseases associated with CKAP2 include inclusion conjunctivitis. An important paralog of this gene is CKAP2L.

UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9
Function: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell
death in a p53/TP53-dependent manner (By similarity)

Gene Wiki entry for CKAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CKAP2 gene promoter:
         NF-YA   CBF-C   PPAR-alpha   NF-YB   CBF-B   CBF-A   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCKAP2 promoter sequence
   Search Chromatin IP Primers for CKAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CKAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14

CKAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKAP2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P053029:  view genomic region     (about GC identifiers)

Start:
53,029,495 bp from pter      End:
53,050,763 bp from pter
Size:
21,269 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9 (See protein sequence)
Recommended Name: Cytoskeleton-associated protein 2  
Size: 683 amino acids; 76987 Da
Subunit: Associates with alpha- and beta-tubulins (By similarity)
Developmental stage: Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis.
Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C)
Sequence caution: Sequence=AAG33675.1; Type=Frameshift; Positions=604; Sequence=AAG33675.1; Type=Frameshift;
Positions=607; Sequence=AAH10901.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI05807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAA91788.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A2BDE0 A5YM58 Q3KRA5 Q5VXB4 Q8IWV5 Q8IWV6 Q96FH9 Q9H012 Q9H0D0 Q9H988
Q9HC49 Q9NVG4
Alternative splicing: 3 isoforms:  Q8WWK9-1   Q8WWK9-4   Q8WWK9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CKAP2: NX_Q8WWK9

Explore proteomics data for CKAP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys70, Lys617, Lys620
  • Modification sites at PhosphoSitePlus

  • See CKAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001091995.1  NP_001273615.1  NP_001273616.1  NP_060674.3  

    ENSEMBL proteins: 
     ENSP00000418431   ENSP00000367273   ENSP00000258607   ENSP00000367276   ENSP00000417830  
     ENSP00000418224  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026165 CKAP2_fam

    Graphical View of Domain Structure for InterPro Entry Q8WWK9

    ProtoNet protein and cluster: Q8WWK9

    UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9
    Similarity: Belongs to the CKAP2 family


    Find genes that share domains with CKAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CKAP2_HUMAN, Q8WWK9
    Function: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell
    death in a p53/TP53-dependent manner (By similarity)
    Induction: Up-regulated in primary human gastric cancers

    Animal Models:

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    hsa-mir-106a-5p (MIRT048321), hsa-mir-222-3p (MIRT046745), hsa-mir-375 (MIRT019751), hsa-let-7b-5p (MIRT052226)

    Block miRNA regulation of human, mouse, rat CKAP2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CKAP2:
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    SwitchGear 3'UTR luciferase reporter plasmidCKAP2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CKAP2_HUMAN, Q8WWK9: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle
    pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules
    in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with
    gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with
    mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA--
    GO:0005881cytoplasmic microtubule IDA16061649
    GO:0015630microtubule cytoskeleton ----

    Find genes that share ontologies with CKAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CKAP2
    Interactions:

        Search GeneGlobe Interaction Network for CKAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CKAP2 (Q8WWK93 ENSP000003672764) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    ARL3ENSP000002607464STRING: ENSP00000260746
    BIRC5ENSP000003016334STRING: ENSP00000301633
    PAFAH1B1ENSP000003803784STRING: ENSP00000380378
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IGI16061649
    GO:0006915apoptotic process IEA--
    GO:0007026negative regulation of microtubule depolymerization IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IGI16061649

    Find genes that share ontologies with CKAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CKAP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CKAP2 gene (4 alternative transcripts): 
    NM_001098525.2  NM_001286686.1  NM_001286687.1  NM_018204.4  

    Unigene Clusters for CKAP2:

    Cytoskeleton associated protein 2
    Hs.444028  [show with all ESTs], Hs.625768  [show with all ESTs]
    Unigene Representative Sequences: NM_001098525, AK025231
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468284 ENST00000378034(uc001vgt.2) ENST00000258607(uc001vgu.2 uc001vgv.2)
    ENST00000378037 ENST00000490903(uc010tha.1) ENST00000480747 ENST00000459902

    miRNA
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    hsa-miR-203 hsa-miR-607 hsa-miR-653 hsa-miR-3613-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidCKAP2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat CKAP2

    Additional mRNA sequence: 

    AB027448.1 AB064011.1 AB064145.1 AB064152.1 AB064153.1 AB064156.1 AB064158.1 AB064160.1 
    AB064161.1 AB064163.1 AB064164.1 AB064168.1 AB064173.1 AB064174.1 AB064175.1 AB064176.1 
    AB064186.1 AB064189.1 AB064202.1 AB064207.1 AB064212.1 AB064215.1 AB064220.1 AB064233.1 
    AB363348.1 AB363366.1 AB369252.1 AF047205.1 AF047227.1 AF047228.1 AF047236.1 AF051809.1 
    AF052760.1 AF052761.1 AF052776.1 AF052778.1 AF052798.1 AF052803.1 AF060139.1 AF060141.1 
    AF060143.1 AF060146.1 AF063708.1 AF063710.1 AF063713.1 AF063734.1 AF063744.1 AF063762.1 
    AF063779.1 AF064496.1 AF064508.1 AF064509.1 AF064511.1 AF090353.1 AF092503.1 AF103644.1 
    AF103645.1 AF103647.1 AF103693.1 AF103697.1 AF103698.1 AF103701.1 AF107250.1 AF194540.1 
    AF194541.1 AF194545.1 AF194546.1 AF194549.1 AF194551.1 AF194553.1 AF194569.1 AF194594.1 
    AF194642.1 AF194647.1 AF194650.1 AF194652.1 AF194653.1 AF194654.1 AF194656.1 AF336988.1 
    AF462675.1 AJ233715.1 AJ233730.1 AJ241414.1 AJ243109.1 AJ318021.1 AJ318022.1 AJ319670.1 
    AJ399866.1 AJ408285.1 AJ410920.1 AK025231.1 AK130415.1 AM181371.1 AY043151.1 AY050712.1 
    AY062361.1 AY485364.1 AY577307.1 AY685383.1 AY942003.1 AY942006.1 AY942038.1 AY942076.1 
    AY962389.1 BC012876.2 BC070352.1 BC070353.1 BC073784.1 BC073786.1 BC073795.1 BC075843.1 
    CR936629.1 DQ205167.1 DQ322744.1 DQ322800.1 DQ322868.1 DQ322932.1 DQ322933.1 DQ322980.1 
    DQ322984.1 DQ322992.1 DQ323020.1 EF028219.1 EF067344.1 EF589388.1 EF589427.1 EF589432.1 
    EF589434.1 EF589446.1 EF589463.1 EF589482.1 EF589494.1 EF589507.1 EF589519.1 EF589529.1 
    EF589538.1 EF589540.1 EF589544.1 EF710911.1 EF710912.1 EF710913.1 EF711087.1 EF711088.1 
    EF711089.1 EU599331.1 FJ385450.1 FJ385513.1 FJ385564.1 GU086862.1 HF541919.1 HM996388.1 
    HQ172110.1 HQ172125.1 HQ172135.1 HQ172138.1 JF740075.1 JF806285.1 JF806287.1 JN130395.1 
    JQ301915.1 JX027461.1 L03626.1 L03627.1 L38428.1 S67985.1 S67988.1 S75627.1 
    U07992.1 U09888.1 U09892.1 U86807.1 U87151.1 U95249.1 X57802.1 X57805.1 
    X57819.1 X87894.1 X99991.1 Y16715.1 Z46627.1 

    Selected DOTS entries (see all 217):

    DT.114665  DT.431254  DT.120678090  DT.87079052  DT.120677661  DT.91962204  DT.95244980  DT.100035257 
    DT.100885122  DT.411116  DT.86992822  DT.91845681  DT.120677346  DT.100046628  DT.95215487  DT.92325691 
    DT.40267692  DT.91832774  DT.100885115  DT.120677853  DT.91769057  DT.86855867  DT.86998433  DT.87002873 

    Selected AceView cDNA sequences (see all 199):

    BM456954 CB136922 AL597509 BM451257 CR590367 CA418142 BU178846 BE350644 
    AA436931 BM846673 AY062261 AA504389 AI499799 CA430297 CR607908 BU631631 
    AA281447 AA748686 AW087631 BU680762 AA436944 AY062262 BX353838 BG681419 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:                                                              -                     
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                          -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CKAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CKAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTAGAGAG
    CKAP2 Expression
    About this image


    CKAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Brain (Nervous System)
             Choroid Plexus Progenitor Cells Choroid Plexus
     
     Colon (Gastrointestinal Tract)
    CKAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CKAP2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.444028 Hs.625768

    UniProtKB/Swiss-Prot: CKAP2_HUMAN, Q8WWK9
    Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver,
    prostate, and kidney

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CKAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CKAP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ckap21 , 5 cytoskeleton associated protein 21, 5 75.18(n)1
    64.42(a)1
      8 (11.13 cM)5
    809861  NM_001004140.21  NP_001004140.21 
     221681525 
    chicken
    (Gallus gallus)
    Aves CKAP21 cytoskeleton associated protein 2 54.46(n)
    37.6(a)
      418882  NM_001006274.1  NP_001006274.1 
    lizard
    (Anolis carolinensis)
    Reptilia CKAP26
    cytoskeleton associated protein 2
    31(a)
    1 ↔ 1
    1(132715573-132740952)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.65562 Transcribed sequence with weak similarity to protein more 72.55(n)    AL891731.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-266i6.31 si:ch211-266i6.3 46.51(n)
    33.95(a)
      568826  XM_692182.5  XP_697274.2 


    ENSEMBL Gene Tree for CKAP2 (if available)
    TreeFam Gene Tree for CKAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CKAP2 gene
    CKAP2L2  

    Find genes that share paralogs with CKAP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CKAP2
    PGOHUM00000247733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CKAP2 (see all 586)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158352951,2
    C,F--53027524(+) TCCCCA/GGACTT 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1412041781,2
    --53027605(+) TTACCG/TTCTTC 2 -- us2k10--------
    rs1913965091,2
    --53027801(+) TAATAC/TTAAAA 2 -- us2k10--------
    rs1161776611,2
    C,F--53027805(+) ATTAAA/GAAGTG 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1507572101,2
    --53027821(+) AAAATA/GGACAT 2 -- us2k10--------
    rs1390872371,2
    --53027903(+) TTTCCC/TATTCA 2 -- us2k10--------
    rs1832045591,2
    --53027965(+) ACCATG/TCCCAC 2 -- us2k10--------
    rs1440069831,2
    --53028064(+) CCAACC/TACTAC 2 -- us2k10--------
    rs1459327031,2
    C--53028349(+) CCCACC/TTGTCT 2 -- us2k10--------
    rs1860168991,2
    --53028373(+) TAAATA/GATCAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CKAP2 (53029495 - 53050763 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CKAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1661627CNV Deletion17803354
    esv2423190CNV Insertion19546169
    nsv428288CNV Loss18775914
    dgv1588n71CNV Loss21882294
    nsv900084CNV Gain21882294
    nsv7242OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CKAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CKAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611569    OMIM disorders: --

    1 disease for CKAP2:    
    About MalaCards
    inclusion conjunctivitis

    3 diseases from the University of Copenhagen DISEASES database for CKAP2:
    Microcephaly     Inclusion conjunctivitis     Otitis media

    Find genes that share disorders with CKAP2           About GenesLikeMe


    Export disorders for CKAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CKAP2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with CKAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B-cell lymphomas. (PubMed id 9771967)1, 2, 3 Maouche-Chretien L.... Leroy-Viard K. (Oncogene 1998)
    2. CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit. (PubMed id 17376772)1, 2 Seki A. and Fang G. (J. Biol. Chem. 2007)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas. (PubMed id 12942315)1, 2 Bae C.-D.... Park J. (J. Cancer Res. Clin. Oncol. 2003)
    7. Evolutionarily-conserved gene CKAP2,located in region 13q14.3 of the human genome, is frequently rearranged in various tumors. (PubMed id 11234418)1, 2 Udina I.G.... Sulimova G.E. (Genetika 2001)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. [The structure of the human oncogenesis-associated CKAP2 (LB1) gene]. (PubMed id 12500535)1, 9 Rakhmanaliev E.R....Sulimova G.E. (Mol. Biol. (Mosk.) 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26586 HGNC: 1990 AceView: CKAP2 Ensembl:ENSG00000136108 euGenes: HUgn26586
    ECgene: CKAP2 H-InvDB: CKAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CKAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CKAP2 gene:
    Search GeneIP for patents involving CKAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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