Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CKAP2 Gene

Aliases for CKAP2 Gene

  • Cytoskeleton Associated Protein 2 2 3 5
  • Tumor- And Microtubule-Associated Protein 3 4
  • CTCL Tumor Antigen Se20-10 3 4
  • TMAP 3 4
  • LB1 3 4
  • Tumor-Associated Microtubule-Associated Protein 3
  • Se20-10 3

External Ids for CKAP2 Gene

Previous GeneCards Identifiers for CKAP2 Gene

  • GC13P050997
  • GC13P047024
  • GC13P051966
  • GC13P050827
  • GC13P051927
  • GC13P053029
  • GC13P033768

Summaries for CKAP2 Gene

Entrez Gene Summary for CKAP2 Gene

  • This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]

GeneCards Summary for CKAP2 Gene

CKAP2 (Cytoskeleton Associated Protein 2) is a Protein Coding gene. Diseases associated with CKAP2 include inclusion conjunctivitis. An important paralog of this gene is CKAP2L.

UniProtKB/Swiss-Prot for CKAP2 Gene

  • Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).

Gene Wiki entry for CKAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKAP2 Gene

Genomics for CKAP2 Gene

Regulatory Elements for CKAP2 Gene

Promoters for CKAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CKAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CKAP2 Gene

Chromosome:
13
Start:
52,455,360 bp from pter
End:
52,476,631 bp from pter
Size:
21,272 bases
Orientation:
Plus strand

Genomic View for CKAP2 Gene

Genes around CKAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP2 Gene

Proteins for CKAP2 Gene

  • Protein details for CKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWK9-CKAP2_HUMAN
    Recommended name:
    Cytoskeleton-associated protein 2
    Protein Accession:
    Q8WWK9
    Secondary Accessions:
    • A2BDE0
    • A5YM58
    • B4DR35
    • E9PD90
    • Q3KRA5
    • Q5VXB4
    • Q8IWV5
    • Q8IWV6
    • Q96FH9
    • Q9H012
    • Q9H0D0
    • Q9H988
    • Q9HC49
    • Q9NVG4

    Protein attributes for CKAP2 Gene

    Size:
    683 amino acids
    Molecular mass:
    76987 Da
    Quaternary structure:
    • Associates with alpha- and beta-tubulins.
    SequenceCaution:
    • Sequence=AAG33675.1; Type=Frameshift; Positions=604; Evidence={ECO:0000305}; Sequence=AAG33675.1; Type=Frameshift; Positions=607; Evidence={ECO:0000305}; Sequence=AAH10901.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI05807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91788.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CKAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKAP2 Gene

Proteomics data for CKAP2 Gene at MOPED

Post-translational modifications for CKAP2 Gene

  • Ubiquitination at Lys 70, Lys 617, and Lys 620
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CKAP2 Gene

Domains & Families for CKAP2 Gene

Protein Domains for CKAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CKAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWK9

UniProtKB/Swiss-Prot:

CKAP2_HUMAN :
  • Belongs to the CKAP2 family.
Family:
  • Belongs to the CKAP2 family.
genes like me logo Genes that share domains with CKAP2: view

No data available for Gene Families for CKAP2 Gene

Function for CKAP2 Gene

Molecular function for CKAP2 Gene

UniProtKB/Swiss-Prot Function:
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in primary human gastric cancers.
genes like me logo Genes that share phenotypes with CKAP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CKAP2 Gene

Localization for CKAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CKAP2 Gene COMPARTMENTS Subcellular localization image for CKAP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CKAP2: view

Pathways & Interactions for CKAP2 Gene

SuperPathways for CKAP2 Gene

No Data Available

SIGNOR curated interactions for CKAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with CKAP2: view

No data available for Pathways by source for CKAP2 Gene

Drugs & Compounds for CKAP2 Gene

(3) Drugs for CKAP2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 863
10-DAB (10-Deacetylbaccatin) Pharma Precursor of antitumor compound Palitaxel and Docetaxel 0
ABT-751 (E7010) Pharma Inhibitor of microtubule polymerization,antimitotic 0

(3) ApexBio Compounds for CKAP2 Gene

Compound Action Cas Number
10-DAB (10-Deacetylbaccatin) Precursor of antitumor compound Palitaxel and Docetaxel 32981-86-5
ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic 141430-65-1
Vincristine Microtubule disrupter,antitumor agent 2068-78-2
genes like me logo Genes that share compounds with CKAP2: view

Transcripts for CKAP2 Gene

Unigene Clusters for CKAP2 Gene

Cytoskeleton associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for CKAP2 Gene

GeneLoc Exon Structure for
CKAP2
ECgene alternative splicing isoforms for
CKAP2

Expression for CKAP2 Gene

mRNA expression in normal human tissues for CKAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CKAP2 Gene

This gene is overexpressed in Testis (32.4), Peripheral blood mononuclear cells (14.7), and Ovary (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CKAP2 Gene



SOURCE GeneReport for Unigene cluster for CKAP2 Gene Hs.444028

mRNA Expression by UniProt/SwissProt for CKAP2 Gene

Q8WWK9-CKAP2_HUMAN
Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
genes like me logo Genes that share expression patterns with CKAP2: view

Protein tissue co-expression partners for CKAP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CKAP2 Gene

Orthologs for CKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CKAP2 35
  • 79.3 (n)
  • 70.65 (a)
CKAP2 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKAP2 35
  • 81.18 (n)
  • 71.17 (a)
CKAP2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ckap2 35
  • 75.18 (n)
  • 64.42 (a)
Ckap2 16
Ckap2 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CKAP2 35
  • 98.98 (n)
  • 97.95 (a)
CKAP2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ckap2 35
  • 74.41 (n)
  • 63.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
chicken
(Gallus gallus)
Aves CKAP2 35
  • 54.46 (n)
  • 37.6 (a)
CKAP2 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CKAP2 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap2 35
  • 51.26 (n)
  • 36.71 (a)
Str.6556 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-266i6.3 35
  • 46.51 (n)
  • 33.95 (a)
CKAP2 36
  • 24 (a)
OneToOne
Species with no ortholog for CKAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CKAP2 Gene

ENSEMBL:
Gene Tree for CKAP2 (if available)
TreeFam:
Gene Tree for CKAP2 (if available)

Paralogs for CKAP2 Gene

Paralogs for CKAP2 Gene

Pseudogenes.org Pseudogenes for CKAP2 Gene

genes like me logo Genes that share paralogs with CKAP2: view

Variants for CKAP2 Gene

Sequence variations from dbSNP and Humsavar for CKAP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs35975899 - 52,461,530(-) CAGTC(A/T)TATTG reference, missense
rs7335867 - 52,461,790(+) AAGTT(A/G)TAGCC reference, missense
rs9379 -- 52,476,344(-) AATTA(C/T)ACAGA utr-variant-3-prime
rs1053245 -- 52,455,200(-) TTGAG(A/T)CCCTC upstream-variant-2KB
rs3892337 -- 52,455,350(-) TGTCT(C/G/T)CCCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CKAP2 Gene

Variant ID Type Subtype PubMed ID
nsv428288 CNV Loss 18775914
nsv900084 CNV Gain 21882294
nsv7242 OTHER Inversion 18451855
dgv1588n71 CNV Loss 21882294
esv2423190 CNV Insertion 19546169
esv1661627 CNV Deletion 17803354

Variation tolerance for CKAP2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CKAP2 Gene

HapMap Linkage Disequilibrium report
CKAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP2 Gene

Disorders for CKAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CKAP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • adult inclusion conjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search CKAP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CKAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CKAP2
genes like me logo Genes that share disorders with CKAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKAP2 Gene

Publications for CKAP2 Gene

  1. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B-cell lymphomas. (PMID: 9771967) Maouche-Chretien L. … Leroy-Viard K. (Oncogene 1998) 2 3 4 67
  2. Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis. (PMID: 19369249) Hong K.U. … Park J. (J. Biol. Chem. 2009) 3 23
  3. Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein. (PMID: 19641375) Hong K.U. … Park J. (Exp. Mol. Med. 2009) 3 23
  4. Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis. (PMID: 18779650) Hong K.U. … Hong K.M. (Exp. Mol. Med. 2008) 3 23
  5. Functional importance of the anaphase-promoting complex-Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis. (PMID: 17339342) Hong K.U. … Park J. (Mol. Cell. Biol. 2007) 3 23

Products for CKAP2 Gene

Sources for CKAP2 Gene

Back to Top

Content