Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CIZ1 Gene

Aliases for CIZ1 Gene

  • CDKN1A Interacting Zinc Finger Protein 1 2 3
  • ZNF356 3 4 6
  • LSFR1 3 4 6
  • NP94 3 4 6
  • Zinc Finger Protein 356 3 4
  • Nuclear Protein NP94 3 4
  • CDKN1A-Interacting Zinc Finger Protein 1 4
  • Cip1-Interacting Zinc Finger Protein 3

External Ids for CIZ1 Gene

Previous GeneCards Identifiers for CIZ1 Gene

  • GC09M122043
  • GC09M122574
  • GC09M124382
  • GC09M126304
  • GC09M128007
  • GC09M129968
  • GC09M130929
  • GC09M100541

Summaries for CIZ1 Gene

Entrez Gene Summary for CIZ1 Gene

  • The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for CIZ1 Gene

CIZ1 (CDKN1A Interacting Zinc Finger Protein 1) is a Protein Coding gene. Diseases associated with CIZ1 include cervical dystonia. GO annotations related to this gene include nucleic acid binding and cyclin binding.

UniProtKB/Swiss-Prot for CIZ1 Gene

  • May regulate the subcellular localization of CIP/WAF1

Gene Wiki entry for CIZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIZ1 Gene

Genomics for CIZ1 Gene

Regulatory Elements for CIZ1 Gene

Genomic Location for CIZ1 Gene

Start:
128,166,064 bp from pter
End:
128,204,383 bp from pter
Size:
38,320 bases
Orientation:
Minus strand

Genomic View for CIZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIZ1 Gene

Proteins for CIZ1 Gene

  • Protein details for CIZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULV3-CIZ1_HUMAN
    Recommended name:
    Cip1-interacting zinc finger protein
    Protein Accession:
    Q9ULV3
    Secondary Accessions:
    • A8K9J8
    • B4E131
    • B7ZAS8
    • Q5SYW3
    • Q5SYW5
    • Q8WU72
    • Q9H868
    • Q9NYM8
    • Q9UHK4
    • Q9Y3F9
    • Q9Y3G0

    Protein attributes for CIZ1 Gene

    Size:
    898 amino acids
    Molecular mass:
    100045 Da
    Quaternary structure:
    • Interacts with CIP/WAF1
    SequenceCaution:
    • Sequence=AAF23231.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF37882.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CIZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIZ1 Gene

Proteomics data for CIZ1 Gene at MOPED

Post-translational modifications for CIZ1 Gene

  • Ubiquitination at Lys830
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CIZ1 Gene

Domains for CIZ1 Gene

Protein Domains for CIZ1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULV3

UniProtKB/Swiss-Prot:

CIZ1_HUMAN :
  • Q9ULV3
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with CIZ1: view

No data available for Gene Families for CIZ1 Gene

Function for CIZ1 Gene

Molecular function for CIZ1 Gene

GENATLAS Biochemistry: CIP1 (CDKN1A interacting zinc finger protein 1,linked to surfeit gene in Fugu rubripes homolog 1
UniProtKB/Swiss-Prot Function: May regulate the subcellular localization of CIP/WAF1

Gene Ontology (GO) - Molecular Function for CIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 18654987
GO:0008270 zinc ion binding IEA --
GO:0030332 cyclin binding --
genes like me logo Genes that share ontologies with CIZ1: view

Phenotypes for CIZ1 Gene

GenomeRNAi human phenotypes for CIZ1:
genes like me logo Genes that share phenotypes with CIZ1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CIZ1 Gene

Localization for CIZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIZ1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIZ1 Gene COMPARTMENTS Subcellular localization image for CIZ1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CIZ1: view

Pathways for CIZ1 Gene

SuperPathways for CIZ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032298 positive regulation of DNA-dependent DNA replication initiation --
GO:0051457 maintenance of protein location in nucleus --
genes like me logo Genes that share ontologies with CIZ1: view

No data available for Pathways by source for CIZ1 Gene

Transcripts for CIZ1 Gene

Unigene Clusters for CIZ1 Gene

CDKN1A interacting zinc finger protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CIZ1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
SP1: - - - - - - - -
SP2:
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - -
SP8: - - - - -
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15: - - -
SP16: -
SP17:

ExUns: 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c
SP1: - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for CIZ1 Gene

GeneLoc Exon Structure for
CIZ1
ECgene alternative splicing isoforms for
CIZ1

Expression for CIZ1 Gene

mRNA expression in normal human tissues for CIZ1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIZ1 Gene

SOURCE GeneReport for Unigene cluster for CIZ1 Gene Hs.212395

genes like me logo Genes that share expressions with CIZ1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CIZ1 Gene

Orthologs for CIZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIZ1 35
  • 99.58 (n)
  • 99.58 (a)
cow
(Bos Taurus)
Mammalia CIZ1 35
  • 84.51 (n)
  • 81.61 (a)
CIZ1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIZ1 35
  • 83.65 (n)
  • 81.76 (a)
CIZ1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ciz1 35
  • 77.86 (n)
  • 70.69 (a)
Ciz1 16
Ciz1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ciz1 35
  • 78.35 (n)
  • 71.48 (a)
lizard
(Anolis carolinensis)
Reptilia CIZ1 36
  • 39 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18815 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11783 35
zebrafish
(Danio rerio)
Actinopterygii ciz1a 36
  • 25 (a)
OneToMany
ciz1b 36
  • 26 (a)
OneToMany
wufi27d02 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5885 36
  • 21 (a)
OneToOne
Species with no ortholog for CIZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIZ1 Gene

ENSEMBL:
Gene Tree for CIZ1 (if available)
TreeFam:
Gene Tree for CIZ1 (if available)

Paralogs for CIZ1 Gene

Selected SIMAP similar genes for CIZ1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CIZ1: view

No data available for Paralogs for CIZ1 Gene

Variants for CIZ1 Gene

Sequence variations from dbSNP and Humsavar for CIZ1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12334 - 128,177,651(-) CTCCT(C/T)CACCC reference, missense
rs15126 -- 128,166,877(+) AGTCC(A/T)CACCA missense, reference
rs870451 -- 128,175,459(-) CTCTC(G/T)CTCTG intron-variant
rs947628 -- 128,170,595(-) TCACT(A/G)CAACT intron-variant
rs1114100 -- 128,171,183(-) AAGTG(C/G)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIZ1 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv893894 CNV Gain 21882294

Relevant External Links for CIZ1 Gene

HapMap Linkage Disequilibrium report
CIZ1
Human Gene Mutation Database (HGMD)
CIZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIZ1 Gene

Disorders for CIZ1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CIZ1 Gene including...

Search for CIZ1 Gene in MalaCards »

UniProtKB/Swiss-Prot

CIZ1_HUMAN
  • Note=Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.
genes like me logo Genes that share disorders with CIZ1: view

Publications for CIZ1 Gene

  1. Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1. (PMID: 10529385) Mitsui K. … Yoshimura A. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC. (PMID: 12824700) Warder D.E. … Keherly M.J. (J. Biomed. Sci. 2003) 3 4 23
  3. Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1. (PMID: 17508423) Rahman F. … Coverley D. (Hum. Mutat. 2007) 3 23
  4. Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer's disease. (PMID: 18583151) Dahmcke C.M. … Mitchelmore C. (Mol. Cell. Neurosci. 2008) 3 23
  5. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 3 4

Products for CIZ1 Gene

Sources for CIZ1 Gene

Back to Top

Content