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CIZ1 Gene

protein-coding   GIFtS: 56
GCID: GC09M130929

CDKN1A Interacting Zinc Finger Protein 1

  See CIZ1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDKN1A Interacting Zinc Finger Protein 11 2     Nuclear Protein NP942 3
LSFR12 3 5     Zinc Finger Protein 3562 3
NP942 3 5     Cip1-Interacting Zinc Finger Protein2
ZNF3562 3 5     CDKN1A-Interacting Zinc Finger Protein 13

External Ids:    HGNC: 167441   Entrez Gene: 257922   Ensembl: ENSG000001483377   OMIM: 6114205   UniProtKB: Q9ULV33   

Export aliases for CIZ1 gene to outside databases

Previous GC identifers: GC09M122043 GC09M122574 GC09M124382 GC09M126304 GC09M128007 GC09M129968 GC09M100541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CIZ1 Gene:
The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex
with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for CIZ1 Gene:
CIZ1 (CDKN1A interacting zinc finger protein 1) is a protein-coding gene. Diseases associated with CIZ1 include cervical dystonia. GO annotations related to this gene include cyclin binding and nucleic acid binding.

UniProtKB/Swiss-Prot: CIZ1_HUMAN, Q9ULV3
Function: May regulate the subcellular localization of CIP/WAF1

Gene Wiki entry for CIZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CIZ1 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CIZ1 promoter sequence
   Search Chromatin IP Primers for CIZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.1

CIZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIZ1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130929:  view genomic region     (about GC identifiers)

Start:
130,928,343 bp from pter      End:
130,966,662 bp from pter
Size:
38,320 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CIZ1_HUMAN, Q9ULV3 (See protein sequence)
Recommended Name: Cip1-interacting zinc finger protein  
Size: 898 amino acids; 100045 Da
Subunit: Interacts with CIP/WAF1
Sequence caution: Sequence=AAF23231.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF37882.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K9J8 B4E131 B7ZAS8 Q5SYW3 Q5SYW5 Q8WU72 Q9H868 Q9NYM8 Q9UHK4 Q9Y3F9
Q9Y3G0
Alternative splicing: 5 isoforms:  Q9ULV3-1   Q9ULV3-2   Q9ULV3-3   Q9ULV3-4   Q9ULV3-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CIZ1: NX_Q9ULV3

Explore proteomics data for CIZ1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys830
  • Modification sites at PhosphoSitePlus

  • See CIZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001124487.1  NP_001124488.1  NP_001124489.1  NP_001124490.1  NP_001244904.1  NP_001244905.1  NP_036259.2  

    ENSEMBL proteins: 
     ENSP00000362045   ENSP00000277465   ENSP00000362039   ENSP00000362029   ENSP00000398011  
     ENSP00000321780   ENSP00000407265   ENSP00000377232   ENSP00000439244   ENSP00000350169  
     ENSP00000320374   ENSP00000445057  

    CIZ1 Human Recombinant Protein Products:

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    Novus Biologicals CIZ1 Protein
    Novus Biologicals CIZ1 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CIZ1

     
    Search eBioscience for Proteins for CIZ1 

    CIZ1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR003604 Znf_U1
     IPR026811 CIZ1
     IPR015880 Znf_C2H2-like
     IPR000690 Znf_C2H2_matrin
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9ULV3

    ProtoNet protein and cluster: Q9ULV3

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: CIZ1_HUMAN, Q9ULV3
    Similarity: Contains 1 matrin-type zinc finger


    Find genes that share domains with CIZ1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIZ1_HUMAN, Q9ULV3
    Function: May regulate the subcellular localization of CIP/WAF1

         Genatlas biochemistry entry for CIZ1:
    CIP1 (CDKN1A interacting zinc finger protein 1,linked to surfeit gene in Fugu rubripes homolog 1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding IPI18654987
    GO:0008270zinc ion binding IEA--
    GO:0030332cyclin binding IEA--
         
    Find genes that share ontologies with CIZ1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CIZ1:
     Actin fiber cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIZ1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIZ1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIZ1

    miRNA
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    miRTarBase miRNAs that target CIZ1:
    hsa-let-7b-5p (MIRT052245), hsa-mir-18a-5p (MIRT050670), hsa-let-7d-5p (MIRT051724), hsa-mir-326 (MIRT043659), hsa-mir-18a-3p (MIRT040834), hsa-mir-615-3p (MIRT040439), hsa-mir-324-3p (MIRT042923)

    Block miRNA regulation of human, mouse, rat CIZ1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CIZ1:
    hsa-miR-1290 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CIZ1

    Gene Editing
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    OriGene clones in human, mouse for CIZ1 (see all 24)
    OriGene ORF clones in mouse, rat for CIZ1
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    GenScript: all cDNA clones in your preferred vector (see all 5): CIZ1 (NM_012127)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIZ1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIZ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CIZ1_HUMAN, Q9ULV3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with CIZ1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CIZ1
    Interactions:

        GeneGlobe Interaction Network for CIZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CIZ1 (Q9ULV31, 3 ENSP000003620294) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3BP4Q9P0V31, 3, ENSP000003402374EBI-2652948,EBI-1049513 I2D: score=1 STRING: ENSP00000340237
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    CDKN1AP389363, ENSP000002447414I2D: score=3 STRING: ENSP00000244741
    SH3KBP1ENSP000003809214STRING: ENSP00000380921
    EZH1ENSP000004046584STRING: ENSP00000404658
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032298positive regulation of DNA-dependent DNA replication initiation IEA--
    GO:0051457maintenance of protein location in nucleus IEA--
    GO:0051658maintenance of nucleus location ----

    Find genes that share ontologies with CIZ1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CIZ1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CIZ1 gene (7 alternative transcripts): 
    NM_001131015.1  NM_001131016.1  NM_001131017.1  NM_001131018.1  NM_001257975.1  NM_001257976.1  NM_012127.2  

    Unigene Cluster for CIZ1:

    CDKN1A interacting zinc finger protein 1
    Hs.212395  [show with all ESTs]
    Unigene Representative Sequence: AK124335
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000471773 ENST00000485862 ENST00000372954 ENST00000461765 ENST00000277465
    ENST00000372948 ENST00000372938(uc004btt.3 uc011mar.2 uc004btx.2)
    ENST00000415526 ENST00000471839 ENST00000491487 ENST00000485001 ENST00000476727
    ENST00000476541 ENST00000475471 ENST00000476239 ENST00000488559 ENST00000467178
    ENST00000491954
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CIZ1:
    hsa-miR-1290 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CIZ1
    Clone
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    OriGene clones in human, mouse for CIZ1 (see all 24)
    OriGene ORF clones in mouse, rat for CIZ1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CIZ1 (NM_012127)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIZ1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CIZ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CIZ1
      QuantiTect SYBR Green Assays in human, mouse, rat CIZ1
      QuantiFast Probe-based Assays in human, mouse, rat CIZ1

    Additional mRNA sequence: 

    AB030835.1 AF159025.1 AF234161.1 AK023978.1 AK027287.1 AK124335.1 AK292713.1 AK296363.1 
    AK303288.1 AK303636.1 AK316393.1 BC004119.2 BC021163.2 EF441870.1 

    Selected DOTS entries (see all 40):

    DT.92451828  DT.100655683  DT.95123933  DT.97864528  DT.121189874  DT.100655681  DT.95143880  DT.100867189 
    DT.97824706  DT.92451819  DT.100655688  DT.121189848  DT.92324446  DT.100044893  DT.101961599  DT.91831541 
    DT.97864529  DT.121189819  DT.100864080  DT.100655684  DT.121189780  DT.121189727  DT.121189802  DT.97864526 

    Selected AceView cDNA sequences (see all 653):

    AI536950 BQ071293 AI244820 BM757318 AW590893 BX415165 BI488815 CA390343 
    BQ671331 CA445786 BM767470 BE294619 BQ057722 AW467311 AA054741 BM764350 
    AI992039 BX387173 BQ065834 AI692581 BU160238 BM738385 BM773222 AW170119 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CIZ1 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
    SP1:        -                 -                                                                                               -     -     -     -     -     -   
    SP2:                                                                                                                                                            
    SP3:        -                                                                                                                                                   
    SP4:        -                                               -                                                                                                   
    SP5:        -     -     -     -                                                                                                                                 

    ExUns: 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c
    SP1:  -     -     -     -     -     -     -     -     -     -     -     -                           
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CIZ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CIZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTACTCA
    CIZ1 Expression
    About this image

    CIZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CIZ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.212395
        Custom PCR Arrays for CIZ1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CIZ1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ciz11 , 5 CDKN1A interacting zinc finger protein 11, 5 77.86(n)1
    70.69(a)1
      2 (22.09 cM)5
    683791  NM_028412.21  NP_082688.11 
     323523275 
    lizard
    (Anolis carolinensis)
    Reptilia CIZ16
    CDKN1A interacting zinc finger protein 1
    39(a)
    1 ↔ 1
    GL343763.1(174930-197547)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188152 Xenopus laevis transcribed sequence with moderate similarity more 82.65(n)    BI446667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi27d022 Danio rerio cDNA clone MGC66467 IMAGE2600996, complete more 74.45(n)    BC055672.1 


    ENSEMBL Gene Tree for CIZ1 (if available)
    TreeFam Gene Tree for CIZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CIZ1 gene
    1 SIMAP similar gene for CIZ1 using alignment to 7 protein entries:     CIZ1_HUMAN (see all proteins):
    LSFR1

    Find genes that share paralogs with CIZ1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CIZ1 (see all 879)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011119631,2
    --130932396(+) ATGAC-/AACAGTC 7 -- int10--------
    rs1446992231,2
    C--130932397(+) TGACA-/ACAGTCA 7 -- int10--------
    rs352831921,2
    C,F--130932398(+) TGACA-/AC/CA 
            
    AGTCA
    7 -- int15NS 180
    rs592322581,2
    C--130932398(+) GACAA-/CAGTCAA 7 -- int12Minor allele frequency- CA:0.25NA 4
    rs751579071,2
    C--130932398(+) GACAAA/C/GAGTCA 7 -- int10--------
    rs350335101,2
    C,F--130933688(+) GTGACAG/-AGAGA 7 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs2002299871,2
    --130933695(+) AGAGA-/GACCCG 7 -- int10--------
    rs588951401,2
    C--130934427(+) AAAAA-/A/AAAA
            
    GAAAA
    7 -- int11NA 2
    rs287142401,2
    F--130934439(+) AAAAAG/AAAAAA 7 -- int1 trp32Minor allele frequency- A:0.50NA 6
    rs107336901,2
    C,F,A,H--130934451(+) AAAAAG/AAAAAA 7 -- int1 trp34Minor allele frequency- A:0.43NA WA CSA 7

    HapMap Linkage Disequilibrium report for CIZ1 (130928343 - 130966662 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CIZ1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8294n71CNV Loss21882294
    nsv893891CNV Loss21882294
    nsv893859CNV Loss21882294
    nsv893894CNV Gain21882294

    Human Gene Mutation Database (HGMD): CIZ1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CIZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for CIZ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611420    OMIM disorders: --

    UniProtKB/Swiss-Prot: CIZ1_HUMAN, Q9ULV3
  • Note=Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the
    presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or
    spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of
    the neck muscles, which produce abnormal posturing of the head upon the trunk

  • 1 disease for CIZ1:    
    About MalaCards
    cervical dystonia


    Find genes that share disorders with CIZ1           About GenesLikeMe


    Export disorders for CIZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CIZ1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with CIZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1. (PubMed id 10529385)1, 2, 3, 9 Mitsui K.... Yoshimura A. (Biochem. Biophys. Res. Commun. 1999)
    2. Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC. (PubMed id 12824700)1, 2, 9 Warder D.E. and Keherly M.J. (J. Biomed. Sci. 2003)
    3. Mutations in CIZ1 cause adult onset primary cervical dystonia. (PubMed id 22447717)1, 2 Xiao J....Ledoux M.S. (Ann. Neurol. 2012)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PubMed id 10369878)1, 2 Gilley J. and Fried M. (Hum. Mol. Genet. 1999)
    6. Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1. (PubMed id 17508423)1, 9 Rahman F....Coverley D. (Hum. Mutat. 2007)
    7. Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer's disease. (PubMed id 18583151)1, 9 Dahmcke C.M....Mitchelmore C. (Mol. Cell. Neurosci. 2008)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Identification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosaccharomyces pombe. (PubMed id 23145069)1 Krzyzanowski M.K....Kozlowski P. (PLoS ONE 2012)
    10. Variant Ciz1 is a circulating biomarker for early-stage lung cancer. (PubMed id 23074256)1 Higgins G....Coverley D. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 25792 HGNC: 16744 AceView: CIZ1 Ensembl:ENSG00000148337 euGenes: HUgn25792
    ECgene: CIZ1 H-InvDB: CIZ1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CIZ1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ciz1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CIZ1 gene:
    Search GeneIP for patents involving CIZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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