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Aliases for CITED4 Gene

Aliases for CITED4 Gene

  • Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 4 2 3
  • Transcriptional Co-Activator 4 2 3
  • MSG1-Related Protein 2 3 4
  • MRG-2 3 4
  • Cbp/P300-Interacting Transactivator 4 3
  • MRG2 4

External Ids for CITED4 Gene

Summaries for CITED4 Gene

Entrez Gene Summary for CITED4 Gene

  • The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

GeneCards Summary for CITED4 Gene

CITED4 (Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 4) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CITED1.

UniProtKB/Swiss-Prot for CITED4 Gene

  • Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CITED4 Gene

Genomics for CITED4 Gene

Genomic Location for CITED4 Gene

Start:
40,861,051 bp from pter
End:
40,862,366 bp from pter
Size:
1,316 bases
Orientation:
Minus strand

Genomic View for CITED4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CITED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CITED4 Gene

Proteins for CITED4 Gene

  • Protein details for CITED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RK1-CITE4_HUMAN
    Recommended name:
    Cbp/p300-interacting transactivator 4
    Protein Accession:
    Q96RK1
    Secondary Accessions:

    Protein attributes for CITED4 Gene

    Size:
    184 amino acids
    Molecular mass:
    18569 Da
    Quaternary structure:
    • Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.

neXtProt entry for CITED4 Gene

Proteomics data for CITED4 Gene at MOPED

Post-translational modifications for CITED4 Gene

No Post-translational modifications

Other Protein References for CITED4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CITED4 Gene

Domains for CITED4 Gene

Protein Domains for CITED4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CITE4_HUMAN
Family:
  • Belongs to the CITED family.:
    • Q96RK1
genes like me logo Genes that share domains with CITED4: view

No data available for Gene Families for CITED4 Gene

Function for CITED4 Gene

Molecular function for CITED4 Gene

UniProtKB/Swiss-Prot Function: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.

Gene Ontology (GO) - Molecular Function for CITED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS --
genes like me logo Genes that share ontologies with CITED4: view

Phenotypes for CITED4 Gene

MGI mutant phenotypes for CITED4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CITED4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CITED4 Gene

Localization for CITED4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CITED4 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CITED4 Gene COMPARTMENTS Subcellular localization image for CITED4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CITED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CITED4: view

Pathways for CITED4 Gene

SuperPathways for CITED4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CITED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0043627 response to estrogen ISS --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CITED4: view

No data available for Pathways by source for CITED4 Gene

Transcripts for CITED4 Gene

mRNA/cDNA for CITED4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(53) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CITED4 Gene

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CITED4 Gene

No ASD Table

Relevant External Links for CITED4 Gene

GeneLoc Exon Structure for
CITED4
ECgene alternative splicing isoforms for
CITED4

Expression for CITED4 Gene

mRNA expression in normal human tissues for CITED4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CITED4 Gene Hs.355820

mRNA Expression by UniProt/SwissProt for CITED4 Gene

Q96RK1-CITE4_HUMAN
Tissue specificity: Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis.
genes like me logo Genes that share expressions with CITED4: view

Orthologs for CITED4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CITED4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CITED4 36
  • 99.09 (n)
  • 98.37 (a)
CITED4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CITED4 36
  • 87.25 (n)
  • 84.15 (a)
CITED4 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CITED4 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cited4 36
  • 79.14 (n)
  • 74.86 (a)
Cited4 16
Cited4 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CITED4 37
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cited4 36
  • 79.58 (n)
  • 76.3 (a)
chicken
(Gallus gallus)
Aves CITED3 37
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cited4a 37
  • 25 (a)
OneToMany
cited4b 37
  • 25 (a)
OneToMany
Species with no ortholog for CITED4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CITED4 Gene

ENSEMBL:
Gene Tree for CITED4 (if available)
TreeFam:
Gene Tree for CITED4 (if available)

Paralogs for CITED4 Gene

Paralogs for CITED4 Gene

genes like me logo Genes that share paralogs with CITED4: view

Variants for CITED4 Gene

Sequence variations from dbSNP and Humsavar for CITED4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs913383 -- 40,863,163(+) GTGTG(C/T)ACAGT upstream-variant-2KB
rs913384 -- 40,863,862(+) CCCCC(C/G)ACCTG upstream-variant-2KB
rs913385 -- 40,864,049(+) TATCT(C/T)GAATC upstream-variant-2KB
rs913386 -- 40,864,098(+) GTGCT(A/G)GGATT upstream-variant-2KB
rs1057635 -- 40,861,609(-) GACTT(G/T)GGGTC reference, missense

Relevant External Links for CITED4 Gene

HapMap Linkage Disequilibrium report
CITED4

No data available for Structural Variations from Database of Genomic Variants (DGV) for CITED4 Gene

Disorders for CITED4 Gene

Relevant External Links for CITED4

Genetic Association Database (GAD)
CITED4
Human Genome Epidemiology (HuGE) Navigator
CITED4
genes like me logo Genes that share disorders with CITED4: view

No data available for UniProtKB/Swiss-Prot for CITED4 Gene

Publications for CITED4 Gene

  1. Human CREB-binding protein/p300-interacting transactivator with ED- rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. (PMID: 11744733) Braganca J. … Bhattacharya S. (J. Biol. Chem. 2002) 2 3 4
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 49
  3. CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. (PMID: 15342390) Fox S.B. … Harris A.L. (Cancer Res. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin. (PMID: 15572674) Labalette C. … Wei Y. (Mol. Cell. Biol. 2004) 3

Products for CITED4 Gene

Sources for CITED4 Gene

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