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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CITED4 Gene

protein-coding GIFtS: 44
GCID: GC01M041362

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal...

Explore 3 diseases affiliated with
CITED4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 4¹ ²
MRG-2² ³
MSG1-Related Protein 2² ³
Cbp/P300-Interacting Transactivator 4²
Transcriptional Co-Activator 4²
MRG2³

External Ids:	HGNC: 18696¹	Entrez Gene: 163732²	Ensembl: ENSG00000179862⁷	OMIM: 606815⁵	UniProtKB: Q96RK1³

Export aliases for CITED4 gene to outside databases

Previous GC identifers: GC01M040330 GC01M040790 GC01M040740 GC01M040995 GC01M041099 GC01M039444

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CITED4:

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to

several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate

gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a

co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in

oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and

overall survival of patients with oligodendroglial tumors. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CITE4_HUMAN, Q96RK1

Function: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by

estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with

CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells,

endothelial cells and mammary epithelial cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CITED4 gene promoter:
HOXA9B HOXA9 GATA-3 AP-2alpha isoform 3 AP-2alpha isoform 2 GATA-2 GATA-1 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CITED4 promoter sequence

Search SABiosciences Chromatin IP Primers for CITED4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CITED4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2|1p35-p34 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.1

CITED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CITED4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M041362: view genomic region (about GC identifiers)

Start:	41,326,728 bp from pter	End:	41,328,018 bp from pter
Size:	1,291 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CITE4_HUMAN, Q96RK1 (See protein sequence)

Recommended Name: Cbp/p300-interacting transactivator 4

Size: 184 amino acids; 18569 Da

Subunit: Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2

isoforms

Subcellular location: Nucleus. Cytoplasm

Explore the universe of human proteins at neXtProt for CITED4: NX_Q96RK1

CITED4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_597724.1

ENSEMBL proteins:

ENSP00000361721

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CITED4
	GenScript Custom Purified and Recombinant Proteins Services for CITED4
	Novus Biologicals CITED4 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CITED4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

CITED4 for ontologies About GeneDecksing

CITED4 Antibody Products:

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	OriGene Antibodies (see all 2): CITED4 OriGene Custom Antibody Services for CITED4
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	Novus Biologicals CITED4 Antibodies
	Abcam antibodies for CITED4
	Uscn Antibodies for CITED4
	ThermoFisher Antibody for CITED4

Assay Products for CITED4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CITED4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CITED4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CITED4 for domains About GeneDecksing

1 InterPro domain/family:

IPR007576 CITED

Graphical View of Domain Structure for InterPro Entry Q96RK1

ProtoNet protein and cluster: Q96RK1

UniProtKB/Swiss-Prot: CITE4_HUMAN, Q96RK1

Similarity: Belongs to the CITED family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CITE4_HUMAN, Q96RK1

Function: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by

estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with

CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells,

endothelial cells and mammary epithelial cells

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CITED4
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CITED4 (see all 13):
		hsa-miR-3130-5p hsa-miR-20a hsa-miR-519d hsa-miR-4328 hsa-miR-106a hsa-miR-106b hsa-miR-659 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: CITED4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CITED4 (see all 7) OriGene shRNA RFP: CITED4 OriGene siRNA: CITED4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CITED4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CITED4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CITED4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CITED4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CITED4 (NM_133467)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CITED4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CITED4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CITED4
		Search LifeMap BioReagents cell lines for CITED4

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CITED4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	ISS	--

CITED4 for ontologies About GeneDecksing

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cited4):

no phenotypic analysis

CITED4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CITED4

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/19 Interacting proteins for CITED4 (Q96RK1³ ENSP00000361721⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TFAP2C	Q92754³, ENSP00000201031⁴	I2D: score=2 STRING: ENSP00000201031
SIRT1	Q96EB6³, ENSP00000212015⁴	I2D: score=1 STRING: ENSP00000212015
EP300	Q09472³, ENSP00000263253⁴	I2D: score=2 STRING: ENSP00000263253
TFAP2A	P05549³, ENSP00000368924⁴	I2D: score=2 STRING: ENSP00000368924
TFAP2B	Q92481³, ENSP00000377265⁴	I2D: score=2 STRING: ENSP00000377265

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0043627	response to estrogen stimulus	ISS	--
GO:0045893	positive regulation of transcription, DNA-dependent	IEA	--

CITED4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CITED4
Search CenterWatch for drugs/clinical trials and news about CITED4 / CITE4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CITED4 gene:

NM_133467.2

Unigene Cluster for CITED4:

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

Hs.355820 [show with all ESTs]

Unigene Representative Sequence: BM909126

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000372638(uc001cgj.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CITED4
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CITED4 (see all 13):
		hsa-miR-3130-5p hsa-miR-20a hsa-miR-519d hsa-miR-4328 hsa-miR-106a hsa-miR-106b hsa-miR-659 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: CITED4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CITED4 (see all 7) OriGene shRNA RFP: CITED4 OriGene siRNA: CITED4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CITED4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CITED4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CITED4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CITED4 (NM_133467)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CITED4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CITED4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CITED4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CITED4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CITED4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CITED4

Additional cDNA sequence:

BC035496.2 BC052559.1

1 DOTS entry:

DT.453789

24/53 AceView cDNA sequences (see all 53):

NM_133467 BC035496 BQ445917 BE048502 AI271898 BC052559 C00201 BQ025809

BQ024919 BU634356 AI244810 CB240666 AI765259 AW059537 BI966153 AA554539

BV184432 CK904042 AI452509 BV206373 BM760997 BV175002 CB850978 CA314741

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CITED4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACGCCGAAC

About this image

CITED4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

Secondary follicles (Primary Cell)

Ovary, Reproductive System

See CITED4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CITED4

SOURCE GeneReport for Unigene cluster: Hs.355820

UniProtKB/Swiss-Prot: CITE4_HUMAN, Q96RK1

Tissue specificity: Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal

muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also

detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to

the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and

increased tumor growth and angiogenesis

SABiosciences Custom PCR Arrays for CITED4

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CITED4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CITED4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CITED4

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CITED4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CITED4 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CITED4¹	Cbp/p300-interacting transactivator, with Glu/Asp-rich more	56.93(n) 46.07(a)		395465 NM_204718.2 NP_990049.1
zebrafish (Danio rerio)	Actinopterygii	cited4a⁶ cited4b⁶	Cbp/p300-interacting transactivator, with Glu/Asp-... Cbp/p300-interacting transactivator, with Glu/Asp-...	27(a) 24(a)	1 ↔ many 1 ↔ many	19(15283260-15287461) 16(39508173-39510493)

ENSEMBL Gene Tree for CITED4 (if available)
TreeFam Gene Tree for CITED4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CITED4 gene

CITED1² CITED2²

CITED4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72949145^1,2	C,	--	41326269(+)	`TTGCCG/TTCACT`	1	--	int¹		4		WA NA EA	360
rs12089233^1,2	C	--	41326351(+)	`TCCCTC/TTGGGA`	1	--	int¹		2		NA	4
rs180901561^1,2		--	41326352(+)	`CCCTCC/TGGGAA`	1	--	int¹		0	--	--	--	--
rs75911301^1,2	C,	--	41326361(+)	`AAACCG/ACCTCA`	1	--	int¹		4		WA NA EA	360
rs186312665^1,2		--	41326407(+)	`GAGTCA/CGGGTC`	1	--	int¹		0	--	--	--	--
rs72949146^1,2	C,	--	41326433(+)	`TGAACT/CCGGTG`	1	--	int¹		4		WA NA EA	360
rs192367545^1,2		--	41326464(+)	`AGAGCA/TCCAAG`	1	--	int¹		0	--	--	--	--
rs72949147^1,2	C,	--	41326480(+)	`CCCACC/GCTACC`	1	--	int¹		4		WA CSA NA	241
rs150909288^1,2		--	41326506(+)	`CCCAGC/TGGGTT`	1	--	int¹		0	--	--	--	--
rs12140441^1,2	C,	--	41326597(+)	`ACTGTC/TGGTTT`	1	--	int¹		3		NA WA	240

HapMap Linkage Disequilibrium report for CITED4 (41326728 - 41328018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CITED4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CITED4

DNA2.0 Custom Variant and Variant Library Synthesis for CITED4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CITED4 for disorders           About GeneDecksing

OMIM gene information: 606815    OMIM disorders: --

3 diseases for CITED4:    About MalaCards

breast cancer glioblastoma hypoxia

Human Genome Epidemiology (HuGE) Navigator: CITED4 (1 document)

Export disorders for CITED4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CITED4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CITED4)

Utopia: connect your pdf to the dynamic
world of online information

Human CREB-binding protein/p300-interacting transactivator with ED- rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. (PubMed id 11744733)^{1, 2, 3} Braganca J.... Bhattacharya S. (2002)
CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. (PubMed id 15342390)^{1, 2} Fox S.B.... Harris A.L. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer. (PubMed id 21755341)¹ Huang K.T....Fox S.B. (2011)
A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)¹ He C....Hunter D.J. (2010)
Mutational analysis of the CITED4 gene in glioblastomas. (PubMed id 18722883)¹ Torres-Martin M....Rey J.A. (2008)
Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. (PubMed id 17311001)¹ Tews B....Lichter P. (2007)
Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin. (PubMed id 15572674)¹ Labalette C....Wei Y. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 163732	HGNC: 18696	AceView: CITED4	Ensembl:ENSG00000179862	euGenes: HUgn163732
ECgene: CITED4	H-InvDB: CITED4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CITED4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CITED4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CITED4 gene:
Search GeneIP for patents involving CITED4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	OriGene Antibodies for CITED4		OriGene shRNA RFP for CITED4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CITED4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CITED4
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CITED4		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CITED4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CITED4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CITED4		OriGene Custom Protein Services for CITED4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CITED4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CITED4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CITED4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CITED4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CITED4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CITED4

	GenScript Custom Purified and Recombinant Proteins Services for CITED4		GenScript cDNA clones with any tag delivered in your preferred vector for CITED4
	GenScript Custom Assay Services for CITED4		GenScript Custom Superior Antibodies Services for CITED4
	GenScript Custom overexpressing Cell Line Services for CITED4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in CITED4 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Antibodies for CITED4
	See all of Abcam's Antibodies, Kits and Proteins for CITED4
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Browse ProSpec Recombinant Proteins

CITED4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CITED4

	Gene Synthesis
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CITED4

	SwitchGear 3'UTR luciferase reporter plasmids for CITED4
	SwitchGear Promoter luciferase reporter plasmids for CITED4

ThermoFisher Antibody for CITED4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CITED4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CITED4 gene at Home site.

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CITED4 Gene

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal...

Aliases
for CITED4 gene

Summaries
for CITED4 gene

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for CITED4 gene

Proteins
for CITED4 gene

Protein Domains /
Families
for CITED4 gene

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CITED4 Gene

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal...

Aliasesfor CITED4 gene

Summariesfor CITED4 gene

Genomic Viewsfor CITED4 gene

Proteinsfor CITED4 gene

Protein Domains /Familiesfor CITED4 gene

Functionfor CITED4 gene

Pathways & Interactionsfor CITED4 gene

Drugs & Compoundsfor CITED4 gene

Transcriptsfor CITED4 gene

Expression for CITED4 gene

Orthologsfor CITED4 gene

Paralogsfor CITED4 gene

Genomic Variantsfor CITED4 gene

Disorders / Diseasesfor CITED4 gene

Publicationsfor CITED4 gene

External Searches for CITED4 gene

Genome Databases showing CITED4 gene

Other Databases showing CITED4 gene

Specialized Databases showing CITED4 gene

Intellectual Propertyfor CITED4 gene

Productsfor CITED4 gene

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Aliases
for CITED4 gene

Summaries
for CITED4 gene

Genomic Views
for CITED4 gene

Proteins
for CITED4 gene

Protein Domains /
Families
for CITED4 gene

Function
for CITED4 gene

Pathways & Interactions
for CITED4 gene

Drugs & Compounds
for CITED4 gene

Transcripts
for CITED4 gene

Expression
for CITED4 gene

Orthologs
for CITED4 gene

Paralogs
for CITED4 gene

Genomic Variants
for CITED4 gene

Disorders / Diseases
for CITED4 gene

Publications
for CITED4 gene

Intellectual Property
for CITED4 gene

Products
for CITED4 gene