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Aliases for CITED1 Gene

Aliases for CITED1 Gene

  • Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 1 2 3
  • Cbp/P300-Interacting Transactivator, With Glu/Asp Rich Carboxy-Terminal Domain, 1 2 3 5
  • Melanocyte-Specific Protein 1 3 4
  • MSG1 3 4
  • Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 1 3
  • Melanocyte-Specific Gene 1 3

External Ids for CITED1 Gene

Previous HGNC Symbols for CITED1 Gene

  • MSG1

Previous GeneCards Identifiers for CITED1 Gene

  • GC0XM067248
  • GC0XM068756
  • GC0XM069754
  • GC0XM070388
  • GC0XM071304
  • GC0XM071438
  • GC0XM071521
  • GC0XM065277

Summaries for CITED1 Gene

Entrez Gene Summary for CITED1 Gene

  • This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for CITED1 Gene

CITED1 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 1) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway and Regulation of nuclear SMAD2/3 signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is CITED4.

UniProtKB/Swiss-Prot for CITED1 Gene

  • Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.

Gene Wiki entry for CITED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CITED1 Gene

Genomics for CITED1 Gene

Regulatory Elements for CITED1 Gene

Promoters for CITED1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CITED1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CITED1 Gene

Chromosome:
X
Start:
72,301,638 bp from pter
End:
72,307,187 bp from pter
Size:
5,550 bases
Orientation:
Minus strand

Genomic View for CITED1 Gene

Genes around CITED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CITED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CITED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CITED1 Gene

Proteins for CITED1 Gene

  • Protein details for CITED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99966-CITE1_HUMAN
    Recommended name:
    Cbp/p300-interacting transactivator 1
    Protein Accession:
    Q99966
    Secondary Accessions:
    • B5BU50
    • B5BUI2

    Protein attributes for CITED1 Gene

    Size:
    193 amino acids
    Molecular mass:
    19896 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CREBBP. Interacts with EGR2 (By similarity). Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300.
    SequenceCaution:
    • Sequence=N30508; Type=Frameshift; Positions=67; Evidence={ECO:0000305};

    Alternative splice isoforms for CITED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CITED1 Gene

Proteomics data for CITED1 Gene at MOPED

Post-translational modifications for CITED1 Gene

  • Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for CITED1

No data available for DME Specific Peptides for CITED1 Gene

Domains & Families for CITED1 Gene

Protein Domains for CITED1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CITED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99966

UniProtKB/Swiss-Prot:

CITE1_HUMAN :
  • Belongs to the CITED family.
Family:
  • Belongs to the CITED family.
genes like me logo Genes that share domains with CITED1: view

No data available for Gene Families for CITED1 Gene

Function for CITED1 Gene

Molecular function for CITED1 Gene

GENATLAS Biochemistry:
CBP/300 interactive transactivator with ED rich tail 1,predominantly expressed in normal melanocytes and pigmented melanoma cells
UniProtKB/Swiss-Prot Function:
Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated by GPR39 in neuronal cells.

Gene Ontology (GO) - Molecular Function for CITED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9707553
GO:0044212 transcription regulatory region DNA binding IDA 11581164
GO:0070410 co-SMAD binding IPI 9707553
genes like me logo Genes that share ontologies with CITED1: view
genes like me logo Genes that share phenotypes with CITED1: view

Animal Models for CITED1 Gene

MGI Knock Outs for CITED1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CITED1 Gene

Localization for CITED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CITED1 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CITED1 Gene COMPARTMENTS Subcellular localization image for CITED1 gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for CITED1 Gene

Pathways & Interactions for CITED1 Gene

genes like me logo Genes that share pathways with CITED1: view

Pathways by source for CITED1 Gene

SIGNOR curated interactions for CITED1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CITED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification IEA --
GO:0001570 vasculogenesis IEA --
GO:0001656 metanephros development TAS 17336183
GO:0001890 placenta development ISS --
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA --
genes like me logo Genes that share ontologies with CITED1: view

Drugs & Compounds for CITED1 Gene

No Compound Related Data Available

Transcripts for CITED1 Gene

Unigene Clusters for CITED1 Gene

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CITED1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: -
SP8: - - - - -

Relevant External Links for CITED1 Gene

GeneLoc Exon Structure for
CITED1
ECgene alternative splicing isoforms for
CITED1

Expression for CITED1 Gene

mRNA expression in normal human tissues for CITED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CITED1 Gene

This gene is overexpressed in Pituitary (x19.1), Testis (x15.1), and Brain - Hypothalamus (x6.1).

Protein differential expression in normal tissues from HIPED for CITED1 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CITED1 Gene



SOURCE GeneReport for Unigene cluster for CITED1 Gene Hs.40403

mRNA Expression by UniProt/SwissProt for CITED1 Gene

Q99966-CITE1_HUMAN
Tissue specificity: Expressed only in melanocytes and testis.
genes like me logo Genes that share expression patterns with CITED1: view

Protein tissue co-expression partners for CITED1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CITED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CITED1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CITED1 35
  • 87.43 (n)
  • 86.39 (a)
CITED1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CITED1 35
  • 86.61 (n)
  • 84.47 (a)
CITED1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cited1 35
  • 78.39 (n)
  • 71.69 (a)
Cited1 16
Cited1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CITED1 35
  • 99.39 (n)
  • 99.54 (a)
CITED1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cited1 35
  • 80.21 (n)
  • 77.08 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CITED1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cited1 35
  • 57.46 (n)
  • 50.75 (a)
zebrafish
(Danio rerio)
Actinopterygii cited1 35
  • 62.47 (n)
  • 53.85 (a)
cited1 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6626 35
Species with no ortholog for CITED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CITED1 Gene

ENSEMBL:
Gene Tree for CITED1 (if available)
TreeFam:
Gene Tree for CITED1 (if available)

Paralogs for CITED1 Gene

Paralogs for CITED1 Gene

genes like me logo Genes that share paralogs with CITED1: view

Variants for CITED1 Gene

Sequence variations from dbSNP and Humsavar for CITED1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs3012627 - 72,302,017(-) ATGCA(C/G)CTGCA reference, missense
rs13669 -- 72,301,939(-) CTGCA(A/T)AACTG reference, missense
rs1047458 -- 72,301,688(-) AAGCC(A/C)CCAAT utr-variant-3-prime
rs1804686 -- 72,301,948(-) GCAGG(A/G)CCCCT reference, synonymous-codon
rs2368671 -- 72,303,800(+) TGATT(C/T)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CITED1 Gene

Variant ID Type Subtype PubMed ID
esv22874 CNV Loss 19812545

Variation tolerance for CITED1 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CITED1 Gene

HapMap Linkage Disequilibrium report
CITED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CITED1 Gene

Disorders for CITED1 Gene

Relevant External Links for CITED1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CITED1

No disorders were found for CITED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CITED1 Gene

Publications for CITED1 Gene

  1. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. (PMID: 8901575) Shioda T. … Isselbacher K.J. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis. (PMID: 9721210) Fenner M.H. … Shioda T. (Genomics 1998) 2 3 23
  3. Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo. (PMID: 11310794) Ahmed N.U. … Ueda M. (Pigment Cell Res. 2001) 3 23
  4. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. (PMID: 10722728) Yahata T. … Shioda T. (J. Biol. Chem. 2000) 3 23
  5. Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas. (PMID: 10644012) Vachtenheim J. … NovotnA! H. (Cell. Mol. Biol. (Noisy-le-grand) 1999) 3 23

Products for CITED1 Gene

Sources for CITED1 Gene

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