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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CITED1 Gene

protein-coding   GIFtS: 59
GCID: GC0XM071521

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal...


(Previous symbol: MSG1)
 Explore 11 diseases affiliated with
CITED1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CITED1    

Aliases
for CITED1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal
Domain, 11 2
MSG11 2 3 5
Melanocyte-Specific Protein 12 3
Cbp/P300-Interacting Transactivator 12
Melanocyte-Specific Gene 12

External Ids:    HGNC: 19861   Entrez Gene: 44352   Ensembl: ENSG000001259317   OMIM: 3001495   UniProtKB: Q999663   

Export aliases for CITED1 gene to outside databases

Previous GC identifers: GC0XM067248 GC0XM068756 GC0XM069754 GC0XM070388 GC0XM071304 GC0XM071438 GC0XM065277


Summaries
for CITED1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CITED1:
This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal
domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a
transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript
variants have been described. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: CITE1_HUMAN, Q99966
Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated
transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP
transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen
receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300.
Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional
coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death.
Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of
osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in
pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a
estrogen-dependent manner

Gene Wiki entry for CITED1


Genomic Views
for CITED1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011669.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CITED1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CITED1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CITED1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

CITED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CITED1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM071521:  view genomic region     (about GC identifiers)

Start:
 71,521,488 bp from pter      End:
 71,527,037 bp from pter
Size:
 5,550 bases      Orientation:
 minus strand

Proteins
for CITED1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CITE1_HUMAN, Q99966 (See protein sequence)
Recommended Name: Cbp/p300-interacting transactivator 1  
Size: 193 amino acids; 19896 Da
Subunit: Interacts (via C-terminus) with CREBBP. Interacts with EGR2 (By similarity). Homodimer. Binds to RBM14.
Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and
SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction
increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with
ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form
preferentially and via C-terminus) with EP300
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export
signal and (NES) in a CRM1-dependent manner
Sequence caution: Sequence=N30508; Type=Frameshift; Positions=67;
Secondary accessions: B5BU50 B5BUI2
Alternative splicing: 2 isoforms:  Q99966-1   Q99966-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CITED1: NX_Q99966

Post-translational modifications:

  • Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator
    • activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99966

    • CITED1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138357.1  NP_001138358.1  NP_001138359.1  NP_004134.2  

    ENSEMBL proteins: 
     ENSP00000401764   ENSP00000362721   ENSP00000407496   ENSP00000246139   ENSP00000414781  
     ENSP00000391407   ENSP00000405765   ENSP00000412769   ENSP00000388548   ENSP00000403274  

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    OriGene Protein Over-expression Lysate (see all 3): CITED1
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    Novus Biologicals CITED1 Proteins
    Novus Biologicals CITED1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CITED1
    Uscn Proteins for CITED1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9434189
    GO:0005737cytoplasm IDA17710162
    GO:0005829cytosol IDA16864582


    CITED1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CITED1

    Protein Domains /
    Families
    for CITED1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CITED1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007576 CITED

    Graphical View of Domain Structure for InterPro Entry Q99966

    ProtoNet protein and cluster: Q99966

    1 Blocks protein family: IPB007576 CITED

    UniProtKB/Swiss-Prot: CITE1_HUMAN, Q99966
    Similarity: Belongs to the CITED family


    Function
    for CITED1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CITE1_HUMAN, Q99966
    Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated
    transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP
    transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen
    receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300.
    Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional
    coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death.
    Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of
    osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in
    pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a
    estrogen-dependent manner
    Induction: Up-regulated by GPR39 in neuronal cells

         Genatlas biochemistry entry for CITED1:
    CBP/300 interactive transactivator with ED rich tail 1,predominantly expressed in normal melanocytes and pigmented
    melanoma cells

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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8901575
    GO:0003713transcription coactivator activity IDA9707553
    GO:0005515protein binding IPI11581164
    GO:0008022protein C-terminus binding IPI15843474


    CITED1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cited1tm1Dunw for CITED1
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cited1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     integument  mortality/aging  renal/urinary system 

    CITED1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CITED1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of nuclear SMAD2/3 signaling
    		Regulation of nuclear SMAD2/3 signaling1.00
    2TGF-beta Receptor Signaling Pathway
    		TGF-beta Receptor Signaling Pathway1.00


    2 BioSystems Pathways for CITED1 
        TGF-beta Receptor Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CITED1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/18 Interacting proteins for CITED1 (Q999661, 2, 3 ENSP000003885484) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054122, 3, ENSP000003602664MINT-6628029 MINT-6628056 I2D: score=1 STRING: ENSP00000360266
    ATF2P153362, 3, ENSP000002641104MINT-6628046 MINT-6628051 I2D: score=1 STRING: ENSP00000264110
    ESR1P033721, 3, ENSP000002062494EBI-2624951,EBI-78473 I2D: score=2 STRING: ENSP00000206249
    CYP27B1O155283, ENSP000002286064I2D: score=1 STRING: ENSP00000228606
    TFAP2CQ927543, ENSP000002010314I2D: score=1 STRING: ENSP00000201031
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000578embryonic axis specification IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001656metanephros development TAS17336183
    GO:0001658branching involved in ureteric bud morphogenesis ISS--
    GO:0001890placenta development ISS--


    CITED1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CITED1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CITED1
    Search CenterWatch for drugs/clinical trials and news about CITED1 / CITE1 

    Transcripts
    for CITED1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CITED1 gene (4 alternative transcripts): 
    NM_001144885.1  NM_001144886.1  NM_001144887.1  NM_004143.3  

    Unigene Cluster for CITED1:

    Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
    Hs.40403  [show with all ESTs]
    Unigene Representative Sequence: NM_004143
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453707 ENST00000373619(uc004eat.3) ENST00000429794 ENST00000246139(uc004eas.3)
    ENST00000417400 ENST00000427412 ENST00000450875 ENST00000454225 ENST00000431381(uc011mqc.2)
    ENST00000445983(uc011mqd.2)

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    Clone
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    Additional cDNA sequence: 

    AB451286.1 AB451418.1 BC004240.1 U65092.1 

    9 DOTS entries:

    DT.100777007  DT.121296633  DT.92463104  DT.453275  DT.86791802  DT.100777006  DT.40112041  DT.95170092 
    DT.91932689 

    24/106 AceView cDNA sequences (see all 106):

    BM904827 BP870754 N71708 BC004240 BM708181 BM707708 BF057265 AA317379 
    CR597324 BM929522 NM_004143 AA972322 H82738 AI217516 AA371828 BU732027 
    BI668281 N44165 AA431128 AW769745 N31365 N36177 BE858491 N31118 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CITED1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8
    SP1:                    -     -     -     -     -     -                                                                           
    SP2:                                      -                 -                                                                     
    SP3:                                      -     -           -                                                                     
    SP4:        -     -     -     -     -     -     -     -     -                                                                     
    SP5:                    -     -     -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for CITED1

    Expression
    for CITED1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CITED1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTAATAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CITED1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartOuter CurvatureCardiomyocytesMyocardium
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    BoneMandibular ProcessBone
    BoneZeugopod Long BoneBone
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    HeartEndocardiumHeart
    LimbAutopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See CITED1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CITED1

    SOURCE GeneReport for Unigene cluster: Hs.40403

    UniProtKB/Swiss-Prot: CITE1_HUMAN, Q99966
    Tissue specificity: Expressed only in melanocytes and testis

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    In Situ
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    Orthologs
    for CITED1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CITED1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cited11 , 5 Cbp/p300-interacting transactivator with Glu/Asp-rich more1, 5 82.38(n)1
    78.76(a)1    		   X (45.25 cM)5
    127051  NM_007709.31  NP_031735.11 
     1022473815 
    zebrafish
    (Danio rerio)    		 Actinopterygii wu:fi05d051 wu:fi05d05 64.3(n)
    57.45(a)    		   793303  NM_001114891.1  NP_001108363.1 


    ENSEMBL Gene Tree for CITED1 (if available)
    TreeFam Gene Tree for CITED1 (if available) 

    Paralogs
    for CITED1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CITED1 gene
    CITED42  CITED22  

    CITED1 for paralogs           About GeneDecksing



    Genomic Variants
    for CITED1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/79 NCBI SNPs in CITED1 are shown (see all 79)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1922949201,2
    		--71521148(+) GCCACA/GTGGCC 4 -- ds50010--------
    rs1430881071,2
    		--71521188(+) TGTAGC/TAAGGA 4 -- ds50010--------
    rs1845232631,2
    		--71521326(+) TGGCAA/GCAGGA 4 -- ds50010--------
    rs1481895221,2
    		--71521346(+) ACAGCC/TCCCTT 4 -- ds50010--------
    rs1896215891,2
    		--71521494(+) TGGCCC/TGTCTC 4 -- ut310--------
    rs2010272311,2
    		--71521548(+) TTATTC/TCTCCA 4 -- ut310--------
    rs1396483681,2
    		C,F--71521598(+) CCGCAG/ATGAAG 8 /T /I mis11Minor allele frequency- A:0.00NA 4550
    rs1411669501,2
    		C,F,--71521633(+) AGCTCC/TGGAAG 8 P syn11Minor allele frequency- T:0.00NA 4550
    rs1457313311,2
    		F--71521669(+) TCCACC/TACCAG 8 V syn11Minor allele frequency- T:0.00NA 4552
    rs2013802091,2
    		C--71521714(+) TCGATC/GATAGC 8 I M mis10--------

    HapMap Linkage Disequilibrium report for CITED1 (71521488 - 71527037 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CITED1
         2 CNVs: 74006 96754
    Locus Specific Mutation Databases (LSDB): CITED1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CITED1
    DNA2.0 Custom Variant and Variant Library Synthesis for CITED1

    Disorders / Diseases
    for CITED1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CITED1 for disorders           About GeneDecksing

    OMIM gene information: 300149    OMIM disorders: --

    11 diseases for CITED1:    About MalaCards
    papillary thyroid carcinoma    wilms tumor    nephroblastoma    thyroid carcinoma
    microphthalmia    thyroiditis    thyroid cancer    melanoma
    breast cancer    carcinoma    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for CITED1:
    Papillary thyroid carcinoma     Nephroblastoma

    3 Novoseek disease relationships for CITED1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nevi 59.3 9 11310794 (4), 15990678 (3), 9683535 (1)
    melanoma 50.9 29 11310794 (6), 15990678 (5), 9683535 (4), 10644012 (3) (see all 6)
    tumors 0 5 15272279 (2), 10644012 (2), 11310794 (1)


    Export disorders for CITED1 gene to outside databases

    Publications
    for CITED1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CITED1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CITED1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. (PubMed id 8901575)1, 2, 3, 9 Shioda T.... Isselbacher K.J. (1996)
    2. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. (PubMed id 10722728)1, 2, 9 Yahata T....Shioda T. (2000)
    3. MSG1 (melanocyte-specific gene 1): mapping to chromos ome Xq13.1, genomic organization, and promoter analysis. (PubMed id 9721210)1, 3, 9 Fenner M.H....Shioda T. (1998)
    4. TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. (PubMed id 21172805)1, 2 Dittmer S.... Methner A. (2011)
    5. The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner. (PubMed id 16864582)1, 2 Shi G....de Caestecker M.P. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. (PubMed id 11581164)1, 2 Yahata T....Shioda T. (2001)
    8. Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. (PubMed id 9707553)1, 2 Shioda T....Isselbacher K.J. (1998)
    9. Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo. (PubMed id 11310794)1, 9 Ahmed N.U....Ueda M. (2001)
    10. Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. (PubMed id 9683535)1, 9 Li H....Shioda T. (1998)

    External Searches for CITED1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing CITED1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4435 HGNC: 1986 AceView: CITED1 Ensembl:ENSG00000125931 euGenes: HUgn4435
    ECgene: CITED1 H-InvDB: CITED1

    Other Databases showing CITED1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CITED1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CITED1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CITED1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CITED1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CITED1 gene:
    Search GeneIP for patents involving CITED1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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