Aliases for CITED1 Gene
External Ids for CITED1 Gene
Previous HGNC Symbols for CITED1 Gene
Previous GeneCards Identifiers for CITED1 Gene
This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for CITED1 Gene
CITED1 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 1) is a Protein Coding gene. Diseases associated with CITED1 include Melanoma. Among its related pathways are TGF-beta Signaling Pathway (WikiPathways) and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is CITED2.
UniProtKB/Swiss-Prot for CITED1 Gene
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.