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Aliases for CITED1 Gene

Aliases for CITED1 Gene

  • Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 1 2 3
  • MSG1 3 4 6
  • Melanocyte-Specific Protein 1 3 4
  • Cbp/P300-Interacting Transactivator 1 3
  • Melanocyte-Specific Gene 1 3

External Ids for CITED1 Gene

Previous HGNC Symbols for CITED1 Gene

  • MSG1

Previous GeneCards Identifiers for CITED1 Gene

  • GC0XM067248
  • GC0XM068756
  • GC0XM069754
  • GC0XM070388
  • GC0XM071304
  • GC0XM071438
  • GC0XM071521
  • GC0XM065277

Summaries for CITED1 Gene

Entrez Gene Summary for CITED1 Gene

  • This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for CITED1 Gene

CITED1 (Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 1) is a Protein Coding gene. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is CITED4.

UniProtKB/Swiss-Prot for CITED1 Gene

  • Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.

Gene Wiki entry for CITED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CITED1 Gene

Genomics for CITED1 Gene

Regulatory Elements for CITED1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CITED1 Gene

Start:
72,301,638 bp from pter
End:
72,307,187 bp from pter
Size:
5,550 bases
Orientation:
Minus strand

Genomic View for CITED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CITED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CITED1 Gene

Proteins for CITED1 Gene

  • Protein details for CITED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99966-CITE1_HUMAN
    Recommended name:
    Cbp/p300-interacting transactivator 1
    Protein Accession:
    Q99966
    Secondary Accessions:
    • B5BU50
    • B5BUI2

    Protein attributes for CITED1 Gene

    Size:
    193 amino acids
    Molecular mass:
    19896 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CREBBP. Interacts with EGR2 (By similarity). Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300.
    SequenceCaution:
    • Sequence=N30508; Type=Frameshift; Positions=67; Evidence={ECO:0000305};

    Alternative splice isoforms for CITED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CITED1 Gene

Proteomics data for CITED1 Gene at MOPED

Post-translational modifications for CITED1 Gene

  • Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CITED1 Gene

Domains for CITED1 Gene

Protein Domains for CITED1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CITED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99966

UniProtKB/Swiss-Prot:

CITE1_HUMAN :
  • Q99966
Family:
  • Belongs to the CITED family.
genes like me logo Genes that share domains with CITED1: view

No data available for Gene Families for CITED1 Gene

Function for CITED1 Gene

Molecular function for CITED1 Gene

GENATLAS Biochemistry: CBP/300 interactive transactivator with ED rich tail 1,predominantly expressed in normal melanocytes and pigmented melanoma cells
UniProtKB/Swiss-Prot Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
UniProtKB/Swiss-Prot Induction: Up-regulated by GPR39 in neuronal cells.

Gene Ontology (GO) - Molecular Function for CITED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 8901575
GO:0003713 transcription coactivator activity IDA 11581164
GO:0005515 protein binding IPI 10327051
GO:0008022 protein C-terminus binding IPI 15843474
genes like me logo Genes that share ontologies with CITED1: view
genes like me logo Genes that share phenotypes with CITED1: view

Animal Models for CITED1 Gene

MGI Knock Outs for CITED1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CITED1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CITED1 Gene

Localization for CITED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CITED1 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CITED1 Gene COMPARTMENTS Subcellular localization image for CITED1 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CITED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16864582
GO:0005737 cytoplasm IDA 16864582
GO:0005829 cytosol IDA 16864582
genes like me logo Genes that share ontologies with CITED1: view

Pathways for CITED1 Gene

genes like me logo Genes that share pathways with CITED1: view

Pathways by source for CITED1 Gene

Gene Ontology (GO) - Biological Process for CITED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification IEA --
GO:0001570 vasculogenesis IEA --
GO:0001656 metanephros development TAS 17336183
GO:0001658 branching involved in ureteric bud morphogenesis ISS --
GO:0001890 placenta development ISS --
genes like me logo Genes that share ontologies with CITED1: view

Transcripts for CITED1 Gene

Unigene Clusters for CITED1 Gene

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CITED1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CITED1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: -
SP8: - - - - -

Relevant External Links for CITED1 Gene

GeneLoc Exon Structure for
CITED1
ECgene alternative splicing isoforms for
CITED1

Expression for CITED1 Gene

mRNA expression in normal human tissues for CITED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CITED1 Gene

This gene is overexpressed in Pituitary (19.1), Testis (15.1), and Brain - Hypothalamus (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CITED1 Gene

SOURCE GeneReport for Unigene cluster for CITED1 Gene Hs.40403

mRNA Expression by UniProt/SwissProt for CITED1 Gene

Q99966-CITE1_HUMAN
Tissue specificity: Expressed only in melanocytes and testis
genes like me logo Genes that share expressions with CITED1: view

In Situ Assay Products

Orthologs for CITED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CITED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CITED1 35
  • 99.39 (n)
  • 99.54 (a)
CITED1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CITED1 35
  • 87.43 (n)
  • 86.39 (a)
CITED1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CITED1 35
  • 86.61 (n)
  • 84.47 (a)
CITED1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cited1 35
  • 78.39 (n)
  • 71.69 (a)
Cited1 16
Cited1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CITED1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cited1 35
  • 80.21 (n)
  • 77.08 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cited1 35
  • 57.46 (n)
  • 50.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6626 35
zebrafish
(Danio rerio)
Actinopterygii cited1 35
  • 62.47 (n)
  • 53.85 (a)
cited1 36
  • 51 (a)
OneToOne
Species with no ortholog for CITED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CITED1 Gene

ENSEMBL:
Gene Tree for CITED1 (if available)
TreeFam:
Gene Tree for CITED1 (if available)

Paralogs for CITED1 Gene

Paralogs for CITED1 Gene

genes like me logo Genes that share paralogs with CITED1: view

Variants for CITED1 Gene

Sequence variations from dbSNP and Humsavar for CITED1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13669 -- 72,301,939(-) CTGCA(A/T)AACTG reference, missense
rs1047458 -- 72,301,688(-) AAGCC(A/C)CCAAT utr-variant-3-prime
rs1804686 -- 72,301,948(-) GCAGG(A/G)CCCCT reference, synonymous-codon
rs2368671 -- 72,303,800(+) TGATT(C/T)CCTGG intron-variant
rs2984343 -- 72,302,276(+) AGTAA(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CITED1 Gene

Variant ID Type Subtype PubMed ID
esv22874 CNV Loss 19812545

Relevant External Links for CITED1 Gene

HapMap Linkage Disequilibrium report
CITED1
Locus Specific Mutation Databases (LSDB)
CITED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CITED1 Gene

Disorders for CITED1 Gene

(2) University of Copenhagen DISEASES for CITED1 Gene

(3) Novoseek inferred disease relationships for CITED1 Gene

Disease -log(P) Hits PubMed IDs
nevi 59.3 8
melanoma 50.9 22
tumors 0 5
genes like me logo Genes that share disorders with CITED1: view

No data available for UniProtKB/Swiss-Prot for CITED1 Gene

Publications for CITED1 Gene

  1. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. (PMID: 8901575) Shioda T. … Isselbacher K.J. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis. (PMID: 9721210) Fenner M.H. … Shioda T. (Genomics 1998) 2 3 23
  3. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. (PMID: 10722728) Yahata T. … Shioda T. (J. Biol. Chem. 2000) 3 4 23
  4. Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo. (PMID: 11310794) Ahmed N.U. … Ueda M. (Pigment Cell Res. 2001) 3 23
  5. Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas. (PMID: 10644012) Vachtenheim J. … NovotnA! H. (Cell. Mol. Biol. (Noisy-le-grand) 1999) 3 23

Products for CITED1 Gene

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Sources for CITED1 Gene

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