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CIT Gene(Protein Coding)

Citron Rho-Interacting Serine/Threonine Kinase

GCID:
GC12M119650
GIFtS:
62
Genes Participants
UDN Logo

Aliases for CIT Gene

Aliases for CIT Gene

  • Citron Rho-Interacting Serine/Threonine Kinase 2 3 5
  • Citron (Rho-Interacting, Serine/Threonine Kinase 21) 2 3
  • Serine/Threonine-Protein Kinase 21 3 4
  • Serine/Threonine Kinase 21 2 3
  • STK21 3 4
  • CRIK 3 4
  • EC 2.7.11.1 4
  • EC 2.7.11 63
  • KIAA0949 4

External Ids for CIT Gene

Previous GeneCards Identifiers for CIT Gene

  • GC12M118996
  • GC12M119906
  • GC12M118535
  • GC12M118586
  • GC12M120123
  • GC12M117131

Summaries for CIT Gene

Entrez Gene Summary for CIT Gene

  • This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for CIT Gene

CIT (Citron Rho-Interacting Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with CIT include Schizophrenia. Among its related pathways are Signaling by Rho GTPases and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot for CIT Gene

  • Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Gene Wiki entry for CIT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIT Gene

Genomics for CIT Gene

Products:

  1. Regulatory Element

Regulatory Elements for CIT Gene

Enhancers for CIT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CIT on UCSC Golden Path with GeneCards custom track

Promoters for CIT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CIT on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CIT gene promoter:

Genomic Location for CIT Gene

Chromosome:
12
Start:
119,685,790 bp from pter
End:
119,877,318 bp from pter
Size:
191,529 bases
Orientation:
Minus strand

Genomic View for CIT Gene

Genes around CIT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIT Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CIT Gene

Proteins for CIT Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14578-CTRO_HUMAN
    Recommended name:
    Citron Rho-interacting kinase
    Protein Accession:
    O14578
    Secondary Accessions:
    • Q2M5E1
    • Q6XUH8
    • Q86UQ9
    • Q9UPZ7

    Protein attributes for CIT Gene

    Size:
    2027 amino acids
    Molecular mass:
    231431 Da
    Quaternary structure:
    • Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
    SequenceCaution:
    • Sequence=BAA76793.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CIT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIT Gene

Proteomics data for CIT Gene at MOPED

Protein Expression for CIT Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CIT Gene

O14578:

Post-translational modifications for CIT Gene

  • Ubiquitination at Lys 350 and Lys 518
  • Modification sites at PhosphoSitePlus

Other Protein References for CIT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CIT Gene

Gene Families for CIT Gene

IUPHAR :

Protein Domains for CIT Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14578

UniProtKB/Swiss-Prot:

CTRO_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CIT: view

Function for CIT Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CIT Gene

GENATLAS Biochemistry:
citron,rho-interacting,serine/threonine kinase 21 with a restricted pattern of expression
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Enzyme Numbers (IUBMB) for CIT Gene

Gene Ontology (GO) - Molecular Function for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA,ISS 9792683
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with CIT: view

Phenotypes for CIT Gene

MGI mutant phenotypes for CIT:
inferred from 2 alleles
GenomeRNAi human phenotypes for CIT:
genes like me logo Genes that share phenotypes with CIT: view

Animal Models for CIT Gene

MGI Knock Outs for CIT:
  • Cit tm1Fdc
  • Cit tm1a(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for CIT

miRNA for CIT Gene

miRTarBase miRNAs that target CIT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIT Gene

Localization for CIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIT Gene COMPARTMENTS Subcellular localization image for CIT gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
vacuole 2

No data available for Gene Ontology (GO) - Cellular Components for CIT Gene

Pathways & Interactions for CIT Gene

genes like me logo Genes that share pathways with CIT: view

Pathways by source for CIT Gene

1 BioSystems pathway for CIT Gene
3 Qiagen pathways for CIT Gene

Gene Ontology (GO) - Biological Process for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0032467 positive regulation of cytokinesis IMP 16431929
GO:0048699 generation of neurons ISS 11086988
genes like me logo Genes that share ontologies with CIT: view

No data available for SIGNOR curated interactions for CIT Gene

Drugs & Compounds for CIT Gene

Products:

  1. Drug

(11) Drugs for CIT Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1910
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1898
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for CIT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with CIT: view

Transcripts for CIT Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CIT Gene

(13) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CIT Gene

Citron (rho-interacting, serine/threonine kinase 21):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36a · 36b ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c ^
SP1: - - - - - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 40a · 40b ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b · 46c ^ 47 ^ 48a · 48b · 48c · 48d ^ 49
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CIT Gene

GeneLoc Exon Structure for
CIT
ECgene alternative splicing isoforms for
CIT

Expression for CIT Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CIT Gene

mRNA expression in normal human tissues for CIT Gene
mRNA expression by BioGPS for CIT GenemRNA expression by GTEx for CIT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CIT Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x5.6), Brain - Putamen (basal ganglia) (x4.5), and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for CIT Gene

This gene is overexpressed in Monocytes (17.8), Brain (14.0), Bone marrow mesenchymal stem cell (13.8), and Frontal cortex (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIT Gene



SOURCE GeneReport for Unigene cluster for CIT Gene Hs.119594

genes like me logo Genes that share expression patterns with CIT: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CIT Gene

Orthologs for CIT Gene

This gene was present in the common ancestor of animals.

Orthologs for CIT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CIT 35
  • 90.72 (n)
  • 96.14 (a)
CIT 36
  • 95 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CIT 35
  • 92.88 (n)
  • 97.78 (a)
CIT 36
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cit 35
  • 89.88 (n)
  • 96.83 (a)
Cit 16
Cit 36
  • 97 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CIT 35
  • 99.6 (n)
  • 99.71 (a)
CIT 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cit 35
  • 90.16 (n)
  • 96.64 (a)
oppossum
(Monodelphis domestica)
 Mammalia CIT 36
  • 93 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CIT 36
  • 84 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CIT 35
  • 80.18 (n)
  • 90.26 (a)
CIT 36
  • 90 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CIT 36
  • 88 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cit 35
  • 74.48 (n)
  • 82.66 (a)
Str.11915 35
zebrafish
(Danio rerio)
 Actinopterygii LOC100329792 35
  • 69.67 (n)
  • 72.49 (a)
CIT (1 of 2) 36
  • 70 (a)
 OneToMany
CIT (2 of 2) 36
  • 72 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG10522 37
  • 30 (a)
sti 35
  • 45.49 (n)
  • 33.52 (a)
sti 36
  • 27 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006932 35
  • 45.97 (n)
  • 32.34 (a)
worm
(Caenorhabditis elegans)
 Secernentea F59A6.5 37
  • 21 (a)
Species with no ortholog for CIT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIT Gene

ENSEMBL:
Gene Tree for CIT (if available)
TreeFam:
Gene Tree for CIT (if available)

Paralogs for CIT Gene

Paralogs for CIT Gene

(20) SIMAP similar genes for CIT Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CIT: view

Variants for CIT Gene

Sequence variations from dbSNP and Humsavar for CIT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs36054900 - 119,876,149(+) GCGCT(C/T)CATAT reference, missense
rs56193743 - 119,876,143(+) GATTC(C/T)GCGCT reference, missense
VAR_040419 -
rs7133437 -- 119,778,806(+) CATAC(C/T)GTTAT intron-variant
rs2074052 -- 119,758,409(+) CGACT(C/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIT Gene

Variant ID Type Subtype PubMed ID
esv1316430 CNV Insertion 17803354
nsv510575 CNV Loss 20534489

Variation tolerance for CIT Gene

Residual Variation Intolerance Score: 0.632% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIT Gene

Human Gene Mutation Database (HGMD)
CIT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIT Gene

Disorders for CIT Gene

MalaCards: The human disease database

(1) MalaCards diseases for CIT Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search CIT in MalaCards View complete list of genes associated with diseases

Relevant External Links for CIT

Genetic Association Database (GAD)
CIT
Human Genome Epidemiology (HuGE) Navigator
CIT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIT
genes like me logo Genes that share disorders with CIT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CIT Gene

Publications for CIT Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. (PMID: 9792683) Di Cunto F. … Dotto G.P. (J. Biol. Chem. 1998) 2 3
  3. Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis. (PMID: 25665131) Horton J.S. … Stokes A.J. (Channels (Austin) 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. [Mechanism Underlying Increased Expression of a Member of the Serine/Threonine Kinase Family (Citron kinase) Induced by HIV-1 Infection]. (PMID: 26524911) Ding J. … Cen S. (Bing Du Xue Bao 2015) 3

Products for CIT Gene

Sources for CIT Gene