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Aliases for CIT Gene

Aliases for CIT Gene

  • Citron Rho-Interacting Serine/Threonine Kinase 2 3 5
  • Citron (Rho-Interacting, Serine/Threonine Kinase 21) 2 3
  • Serine/Threonine-Protein Kinase 21 3 4
  • Serine/Threonine Kinase 21 2 3
  • STK21 3 4
  • CRIK 3 4
  • Citron Rho-Interacting Kinase 3
  • EC 2.7.11.1 4
  • EC 2.7.11 61
  • KIAA0949 4
  • MCPH17 3
  • CITK 3

External Ids for CIT Gene

Previous GeneCards Identifiers for CIT Gene

  • GC12M118996
  • GC12M119906
  • GC12M118535
  • GC12M118586
  • GC12M120123
  • GC12M117131

Summaries for CIT Gene

Entrez Gene Summary for CIT Gene

  • This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for CIT Gene

CIT (Citron Rho-Interacting Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with CIT include Autosomal Recessive Primary Microcephaly and Microcephaly 17, Primary, Autosomal Recessive. Among its related pathways are Semaphorin interactions and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPB.

UniProtKB/Swiss-Prot for CIT Gene

  • Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Gene Wiki entry for CIT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIT Gene

Genomics for CIT Gene

Regulatory Elements for CIT Gene

Enhancers for CIT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F119715 1.2 FANTOM5 Ensembl ENCODE 12.4 +160.9 160884 2.0 ELF3 MLX ARID4B SIN3A THRB RAD21 RARA YY1 SCRT2 RCOR1 CIT MIR1178 TMEM233 PRKAB1 GC12P119728 ENSG00000255692
GH12F119678 1 Ensembl ENCODE 12.1 +193.9 193888 9.7 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PRKAB1 CIT MIR1178 LOC105370027 TMEM233 ENSG00000255692
GH12F119876 0.2 ENCODE 7.4 +0.1 144 1.9 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLIS2 ZNF143 KLF7 FOS GCN1 CIT MIR1178 GC12P119728
GH12F119803 0.9 ENCODE 4.8 +73.4 73370 1.9 ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF766 GLIS2 GATA2 ZNF143 CIT MIR1178 GC12P119728
GH12F119902 0.5 ENCODE 0.3 -24.9 -24914 0.2 ELF3 ZNF2 RAD21 RFX5 GATA2 ZNF143 ZNF207 RCOR1 ZNF654 ZHX2 ENSG00000279777 CIT
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CIT on UCSC Golden Path with GeneCards custom track

Promoters for CIT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091362 118 1600 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLIS2 ZNF143 KLF7 FOS

Genomic Location for CIT Gene

Chromosome:
12
Start:
119,685,790 bp from pter
End:
119,877,318 bp from pter
Size:
191,529 bases
Orientation:
Minus strand

Genomic View for CIT Gene

Genes around CIT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIT Gene

Proteins for CIT Gene

  • Protein details for CIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14578-CTRO_HUMAN
    Recommended name:
    Citron Rho-interacting kinase
    Protein Accession:
    O14578
    Secondary Accessions:
    • Q2M5E1
    • Q6XUH8
    • Q86UQ9
    • Q9UPZ7

    Protein attributes for CIT Gene

    Size:
    2027 amino acids
    Molecular mass:
    231431 Da
    Quaternary structure:
    • Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
    • Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
    SequenceCaution:
    • Sequence=BAA76793.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CIT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIT Gene

Selected DME Specific Peptides for CIT Gene

Post-translational modifications for CIT Gene

  • Ubiquitination at Lys 350 and Lys 518
  • Modification sites at PhosphoSitePlus

Domains & Families for CIT Gene

Suggested Antigen Peptide Sequences for CIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14578

UniProtKB/Swiss-Prot:

CTRO_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CIT: view

Function for CIT Gene

Molecular function for CIT Gene

GENATLAS Biochemistry:
citron,rho-interacting,serine/threonine kinase 21 with a restricted pattern of expression
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Enzyme Numbers (IUBMB) for CIT Gene

Gene Ontology (GO) - Molecular Function for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS 9792683
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CIT: view
genes like me logo Genes that share phenotypes with CIT: view

Animal Models for CIT Gene

MGI Knock Outs for CIT:
  • Cit tm1Fdc
  • Cit tm1a(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for CIT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIT Gene

Localization for CIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIT Gene COMPARTMENTS Subcellular localization image for CIT gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CIT: view

Pathways & Interactions for CIT Gene

genes like me logo Genes that share pathways with CIT: view

Pathways by source for CIT Gene

1 BioSystems pathway for CIT Gene
3 Qiagen pathways for CIT Gene

Gene Ontology (GO) - Biological Process for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000281 mitotic cytokinesis IMP 27453578
GO:0000910 cytokinesis IMP 16236794
GO:0006468 protein phosphorylation IEA --
GO:0007030 Golgi organization IEA --
genes like me logo Genes that share ontologies with CIT: view

No data available for SIGNOR curated interactions for CIT Gene

Drugs & Compounds for CIT Gene

(10) Drugs for CIT Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1980
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2690
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1974
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for CIT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with CIT: view

Transcripts for CIT Gene

mRNA/cDNA for CIT Gene

Unigene Clusters for CIT Gene

Citron (rho-interacting, serine/threonine kinase 21):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36a · 36b ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c ^
SP1: - - - - - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 40a · 40b ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b · 46c ^ 47 ^ 48a · 48b · 48c · 48d ^ 49
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CIT Gene

GeneLoc Exon Structure for
CIT
ECgene alternative splicing isoforms for
CIT

Expression for CIT Gene

mRNA expression in normal human tissues for CIT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CIT Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x5.6), Brain - Putamen (basal ganglia) (x4.5), and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for CIT Gene

This gene is overexpressed in Monocytes (17.8), Brain (14.0), Bone marrow mesenchymal stem cell (13.8), and Frontal cortex (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CIT Gene



NURSA nuclear receptor signaling pathways regulating expression of CIT Gene:

CIT

SOURCE GeneReport for Unigene cluster for CIT Gene:

Hs.119594
genes like me logo Genes that share expression patterns with CIT: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CIT Gene

Orthologs for CIT Gene

This gene was present in the common ancestor of animals.

Orthologs for CIT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIT 34 35
  • 99.6 (n)
oppossum
(Monodelphis domestica)
Mammalia CIT 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIT 34 35
  • 92.88 (n)
cow
(Bos Taurus)
Mammalia CIT 34 35
  • 90.72 (n)
rat
(Rattus norvegicus)
Mammalia Cit 34
  • 90.16 (n)
mouse
(Mus musculus)
Mammalia Cit 34 16 35
  • 89.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CIT 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CIT 34 35
  • 80.18 (n)
lizard
(Anolis carolinensis)
Reptilia CIT 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cit 34
  • 74.48 (n)
Str.11915 34
zebrafish
(Danio rerio)
Actinopterygii CIT (2 of 2) 35
  • 72 (a)
OneToMany
CIT (1 of 2) 35
  • 70 (a)
OneToMany
LOC100329792 34
  • 69.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006932 34
  • 45.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta sti 34 35
  • 45.49 (n)
CG10522 36
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea F59A6.5 36
  • 21 (a)
Species where no ortholog for CIT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIT Gene

ENSEMBL:
Gene Tree for CIT (if available)
TreeFam:
Gene Tree for CIT (if available)

Paralogs for CIT Gene

genes like me logo Genes that share paralogs with CIT: view

Variants for CIT Gene

Sequence variations from dbSNP and Humsavar for CIT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_077442 Microcephaly 17, primary, autosomal recessive (MCPH17) [MIM:617090]
VAR_077443 Microcephaly 17, primary, autosomal recessive (MCPH17) [MIM:617090]
VAR_077444 Microcephaly 17, primary, autosomal recessive (MCPH17) [MIM:617090]
rs879253817 Pathogenic 119,876,131(-) GCGGA(-/ATCCTTTGGA)TGCTG reference, frameshift-variant
rs879255522 Pathogenic 119,822,819(-) TAACT(A/G)TAAGT splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for CIT Gene

Variant ID Type Subtype PubMed ID
esv1316430 CNV insertion 17803354
esv3630913 CNV loss 21293372
esv3630914 CNV loss 21293372
nsv475444 CNV novel sequence insertion 20440878
nsv476317 CNV novel sequence insertion 20440878
nsv510575 CNV deletion 20534489
nsv560397 CNV gain 21841781

Variation tolerance for CIT Gene

Residual Variation Intolerance Score: 0.632% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIT Gene

Human Gene Mutation Database (HGMD)
CIT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIT Gene

Disorders for CIT Gene

MalaCards: The human disease database

(4) MalaCards diseases for CIT Gene - From: ClinVar, Orphanet, Swiss-Prot, and GeneCards