Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CIT Gene

Aliases for CIT Gene

  • Citron Rho-Interacting Serine/Threonine Kinase 2 3
  • STK21 3 4 6
  • Citron (Rho-Interacting, Serine/Threonine Kinase 21) 2 3
  • Serine/Threonine-Protein Kinase 21 3 4
  • Serine/Threonine Kinase 21 2 3
  • CRIK 3 4
  • Citron Rho-Interacting Kinase 3
  • EC 2.7.11.1 4
  • EC 2.7.11 63
  • KIAA0949 4
  • CRIK, 6

External Ids for CIT Gene

Previous GeneCards Identifiers for CIT Gene

  • GC12M118996
  • GC12M119906
  • GC12M118535
  • GC12M118586
  • GC12M120123
  • GC12M117131

Summaries for CIT Gene

Entrez Gene Summary for CIT Gene

  • This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for CIT Gene

CIT (Citron Rho-Interacting Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with CIT include bipolar disorder and schizophrenia. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include protein serine/threonine kinase activity and SH3 domain binding. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for CIT Gene

  • Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Gene Wiki entry for CIT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIT Gene

Genomics for CIT Gene

Genomic Location for CIT Gene

Start:
119,685,790 bp from pter
End:
119,877,291 bp from pter
Size:
191,502 bases
Orientation:
Minus strand

Genomic View for CIT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIT Gene

Proteins for CIT Gene

  • Protein details for CIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14578-CTRO_HUMAN
    Recommended name:
    Citron Rho-interacting kinase
    Protein Accession:
    O14578
    Secondary Accessions:
    • Q2M5E1
    • Q6XUH8
    • Q86UQ9
    • Q9UPZ7

    Protein attributes for CIT Gene

    Size:
    2027 amino acids
    Molecular mass:
    231431 Da
    Quaternary structure:
    • Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
    SequenceCaution:
    • Sequence=BAA76793.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CIT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIT Gene

Proteomics data for CIT Gene at MOPED

Selected DME Specific Peptides for CIT Gene

Post-translational modifications for CIT Gene

  • Ubiquitination at Lys350 and Lys518
  • Modification sites at PhosphoSitePlus

Other Protein References for CIT Gene

Domains for CIT Gene

Suggested Antigen Peptide Sequences for CIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14578

UniProtKB/Swiss-Prot:

CTRO_HUMAN :
  • O14578
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CIT: view

Function for CIT Gene

Molecular function for CIT Gene

GENATLAS Biochemistry: citron,rho-interacting,serine/threonine kinase 21 with a restricted pattern of expression
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Enzyme Numbers (IUBMB) for CIT Gene

Gene Ontology (GO) - Molecular Function for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS 9792683
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CIT: view
genes like me logo Genes that share phenotypes with CIT: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIT

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CIT Gene

Localization for CIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIT Gene COMPARTMENTS Subcellular localization image for CIT gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm --
GO:0005773 vacuole IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CIT: view

Pathways for CIT Gene

genes like me logo Genes that share pathways with CIT: view

Pathways by source for CIT Gene

3 Qiagen pathways for CIT Gene
1 BioSystems pathway for CIT Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IEA --
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000910 cytokinesis IMP 16236794
GO:0006468 protein phosphorylation IEA --
GO:0007030 Golgi organization IEA --
genes like me logo Genes that share ontologies with CIT: view

Compounds for CIT Gene

(846) HMDB Compounds for CIT Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
genes like me logo Genes that share compounds with CIT: view

Transcripts for CIT Gene

mRNA/cDNA for CIT Gene

Unigene Clusters for CIT Gene

Citron (rho-interacting, serine/threonine kinase 21):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIT

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CIT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36a · 36b ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c ^
SP1: - - - - - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 40a · 40b ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b · 46c ^ 47 ^ 48a · 48b · 48c · 48d ^ 49
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CIT Gene

GeneLoc Exon Structure for
CIT
ECgene alternative splicing isoforms for
CIT

Expression for CIT Gene

mRNA expression in normal human tissues for CIT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CIT Gene

This gene is overexpressed in Brain - Cortex (5.8), Brain - Frontal Cortex (BA9) (5.6), Brain - Putamen (basal ganglia) (4.5), and Brain - Caudate (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIT Gene

SOURCE GeneReport for Unigene cluster for CIT Gene Hs.119594

genes like me logo Genes that share expressions with CIT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CIT Gene

Orthologs for CIT Gene

This gene was present in the common ancestor of animals.

Orthologs for CIT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIT 35
  • 99.6 (n)
  • 99.71 (a)
CIT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CIT 35
  • 90.72 (n)
  • 96.14 (a)
CIT 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIT 35
  • 92.88 (n)
  • 97.78 (a)
CIT 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cit 35
  • 89.88 (n)
  • 96.83 (a)
Cit 16
Cit 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIT 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CIT 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cit 35
  • 90.16 (n)
  • 96.64 (a)
chicken
(Gallus gallus)
Aves CIT 35
  • 80.18 (n)
  • 90.26 (a)
CIT 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CIT 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cit 35
  • 74.48 (n)
  • 82.66 (a)
Str.11915 35
zebrafish
(Danio rerio)
Actinopterygii CIT (1 of 2) 36
  • 70 (a)
OneToMany
CIT (2 of 2) 36
  • 72 (a)
OneToMany
LOC100329792 35
  • 69.67 (n)
  • 72.49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006932 35
  • 45.97 (n)
  • 32.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta sti 35
  • 45.49 (n)
  • 33.52 (a)
sti 36
  • 27 (a)
OneToOne
CG10522 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea F59A6.5 37
  • 21 (a)
Species with no ortholog for CIT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIT Gene

ENSEMBL:
Gene Tree for CIT (if available)
TreeFam:
Gene Tree for CIT (if available)

Paralogs for CIT Gene

genes like me logo Genes that share paralogs with CIT: view

Variants for CIT Gene

Sequence variations from dbSNP and Humsavar for CIT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4214 -- 119,702,143(+) tctgt(A/C)accta intron-variant
rs4269 -- 119,711,753(+) TGGGC(A/G)ATCCG intron-variant
rs45670 -- 119,749,126(-) CTCTC(A/G)ACTGA intron-variant
rs169408 -- 119,777,530(+) ccagg(C/T)gtggt intron-variant
rs172167 -- 119,854,256(+) ctccc(A/G)acctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIT Gene

Variant ID Type Subtype PubMed ID
esv1316430 CNV Insertion 17803354
nsv510575 CNV Loss 20534489

Relevant External Links for CIT Gene

HapMap Linkage Disequilibrium report
CIT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIT Gene

Disorders for CIT Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CIT Gene including...

Search for CIT Gene in MalaCards »

Relevant External Links for CIT

Genetic Association Database (GAD)
CIT
Human Genome Epidemiology (HuGE) Navigator
CIT
genes like me logo Genes that share disorders with CIT: view

No data available for UniProtKB/Swiss-Prot for CIT Gene

Publications for CIT Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  2. Evidence of association between bipolar disorder and Citron on chromosome 12q24. (PMID: 15983625) Lyons-Warren A. … Sawa A. (Mol. Psychiatry 2005) 3 4
  3. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PMID: 16236794) Kamijo K. … Miki T. (Mol. Biol. Cell 2006) 3 4
  4. KIF14 and citron kinase act together to promote efficient cytokinesis. (PMID: 16431929) Gruneberg U. … Barr F.A. (J. Cell Biol. 2006) 3 4
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4

Products for CIT Gene

Sources for CIT Gene

Back to Top

Content