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CIT Gene

protein-coding   GIFtS: 65
GCID: GC12M120123

Citron (Rho-Interacting, Serine/Threonine Kinase 21)

  See CIT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Citron (Rho-Interacting, Serine/Threonine Kinase 21)1 2     Citron Rho-Interacting Kinase2
CRIK2 3 5     EC 2.7.11.13
STK212 3 5     KIAA09493
Serine/Threonine-Protein Kinase 212 3     EC 2.7.118

External Ids:    HGNC: 19851   Entrez Gene: 111132   Ensembl: ENSG000001229667   OMIM: 6056295   UniProtKB: O145783   

Export aliases for CIT gene to outside databases

Previous GC identifers: GC12M118996 GC12M119650 GC12M119906 GC12M118535 GC12M118586 GC12M117131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CIT Gene:
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin
KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis.
This protein is involved in central nervous system development. Polymorphisms in this gene are associated with
bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Aug 2011)

GeneCards Summary for CIT Gene:
CIT (citron (rho-interacting, serine/threonine kinase 21)) is a protein-coding gene. Diseases associated with CIT include bipolar disorder, and schizophrenia. GO annotations related to this gene include SH3 domain binding and protein serine/threonine kinase activity. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: CTRO_HUMAN, O14578
Function: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody.
Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter
specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation
of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation
of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2

Gene Wiki entry for CIT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CIT gene promoter:
         NF-1   Elk-1   Bach2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   E47   Gfi-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CIT promoter sequence
   Search Chromatin IP Primers for CIT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.23

CIT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIT gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120123:  view genomic region     (about GC identifiers)

Start:
120,123,595 bp from pter      End:
120,315,095 bp from pter
Size:
191,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTRO_HUMAN, O14578 (See protein sequence)
Recommended Name: Citron Rho-interacting kinase  
Size: 2027 amino acids; 231431 Da
Subunit: Directly interacts with KIF14 depending on the activation state (stronger interaction with the
kinase-dead form). Homodimer (By similarity). Interacts with TTC3
Sequence caution: Sequence=BAA76793.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q2M5E1 Q6XUH8 Q86UQ9 Q9UPZ7
Alternative splicing: 4 isoforms:  O14578-1   O14578-2   O14578-3   O14578-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CIT: NX_O14578

Explore proteomics data for CIT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys350, Lys518
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for CIT (O14578)
     YMAPEVL  HRDIKPEN 


    See CIT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193928.1  NP_009105.1  

    ENSEMBL proteins: 
     ENSP00000376306   ENSP00000261833   ENSP00000376305   ENSP00000443199   ENSP00000446105  

    CIT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CIT
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CIT
    GenScript Custom Purified and Recombinant Proteins Services for CIT
    Novus Biologicals CIT Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CIT

     
    Search eBioscience for Proteins for CIT 

    CIT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CIT
    OriGene Custom Antibody Services for CIT
    Novus Biologicals CIT Antibodies
    Abcam antibodies for CIT
    Cloud-Clone Corp. Antibodies for CIT
    ThermoFisher Antibodies for CIT
    LSBio Antibodies in human, mouse, rat for CIT

    CIT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CIT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CIT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CIT
    Cloud-Clone Corp. CLIAs for CIT
    Search eBioscience for ELISAs for CIT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: citron (rho-interacting, serine/threonine kinase 21)
    Other DMPK family kinases
    Other AGC kinases

    Selected InterPro protein domains (see all 13):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR017405 Citron_Rho-interacting_kinase
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry O14578

    ProtoNet protein and cluster: O14578

    3 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001180 Citron-like
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: CTRO_HUMAN, O14578
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CIT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTRO_HUMAN, O14578
    Function: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody.
    Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter
    specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation
    of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation
    of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CIT:
    citron,rho-interacting,serine/threonine kinase 21 with a restricted pattern of expression

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS9792683
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CIT           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for CIT:
     Cell division defect  Decreased cell number  Decreased substrate adherent c  Increased cell death in breast 
     Increased colony dispersion (i  Increases Tamoxifen sensitivit  Paclitaxel antagonistic effect  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cit):
     behavior/neurological  cellular  growth/size/body  mortality/aging  muscle 
     nervous system  reproductive system  skeleton 

    Find genes that share phenotypes with CIT           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CIT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIT

    miRNA
    Products:
        
    miRTarBase miRNAs that target CIT:
    hsa-mir-92b-3p (MIRT040664), hsa-mir-215-5p (MIRT024814), hsa-mir-92a-3p (MIRT048952), hsa-mir-192-5p (MIRT026796), hsa-mir-93-3p (MIRT038779), hsa-mir-29b-3p (MIRT048374)

    Block miRNA regulation of human, mouse, rat CIT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CIT (see all 71):
    hsa-miR-4254 hsa-miR-106a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-502-3p hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCIT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CIT
    Predesigned siRNA for gene silencing in human, mouse, rat CIT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CIT

    Clone
    Products:
         
    OriGene clones in human, mouse for CIT (see all 6)
    OriGene ORF clones in mouse, rat for CIT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CIT (NM_004143)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIT

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CIT
    Browse ESI BIO Cell Lines and PureStem Progenitors for CIT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTRO_HUMAN, O14578: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2
    vacuole2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm ----
    GO:0005773vacuole IEA--
    GO:0005886plasma membrane IEA--
    GO:0015629actin cytoskeleton IEA--

    Find genes that share ontologies with CIT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CIT About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Rho Family GTPases0.61
    2Sweet Taste Signaling
    Sperm Motility0.37
    3Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35
    4G13 Signaling Pathway
    G13 Signaling Pathway

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CIT
        RhoA Pathway
    Rho Family GTPases
    Sperm Motility

    1 BioSystems Pathway for CIT
        G13 Signaling Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including CIT: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CIT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CIT (O145782, 3 ENSP000002618334) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYL12AP191052, 3, ENSP000002176524MINT-8150240 I2D: score=1 STRING: ENSP00000217652
    GRIN1Q055863, ENSP000003606164I2D: score=3 STRING: ENSP00000360616
    RHOAP615863, ENSP000004001754I2D: score=3 STRING: ENSP00000400175
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    GRIN2DO153993, ENSP000002632694I2D: score=1 STRING: ENSP00000263269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation IEA--
    GO:0000086G2/M transition of mitotic cell cycle IEA--
    GO:0000910cytokinesis IMP16236794
    GO:0006468protein phosphorylation ----
    GO:0007030Golgi organization IEA--

    Find genes that share ontologies with CIT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CIT (CTRO)

    Selected HMDB Compounds for CIT (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CIT gene (2 alternative transcripts): 
    NM_001206999.1  NM_007174.2  

    Unigene Cluster for CIT:

    Citron (rho-interacting, serine/threonine kinase 21)
    Hs.119594  [show with all ESTs]
    Unigene Representative Sequence: NM_001206999
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392521(uc001txj.2 uc001txi.2) ENST00000261833 ENST00000545913(uc001txh.2)
    ENST00000392520 ENST00000537607 ENST00000544872 ENST00000469414 ENST00000538073
    ENST00000543324 ENST00000544800 ENST00000543239 ENST00000536008 ENST00000544588
    ENST00000536325 ENST00000546026 ENST00000541841 ENST00000488203 ENST00000539413

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CIT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CIT (see all 71):
    hsa-miR-4254 hsa-miR-106a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-502-3p hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCIT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CIT
    Predesigned siRNA for gene silencing in human, mouse, rat CIT
    Clone
    Products:
         
    OriGene clones in human, mouse for CIT (see all 6)
    OriGene ORF clones in mouse, rat for CIT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CIT (NM_004143)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIT
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CIT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CIT
      QuantiTect SYBR Green Assays in human, mouse, rat CIT
      QuantiFast Probe-based Assays in human, mouse, rat CIT

    Additional mRNA sequence: 

    AB023166.2 AY209000.1 AY257469.1 AY681966.1 BC008127.1 BC047647.1 

    17 DOTS entries:

    DT.315805  DT.91751844  DT.40313426  DT.91727375  DT.100782764  DT.92425326  DT.206074  DT.206211 
    DT.92062035  DT.100763091  DT.121153912  DT.121153933  DT.91882000  DT.97791921  DT.100656489  DT.102827490 
    DT.40108584 

    8 AceView cDNA sequences:

    NM_007174 BC008127 AB023166 AY257469 BC047647 AK123136 AY209000 D16893 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CIT (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                        -     -                                                                 -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36a · 36b ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c ^
    SP1:        -                                                     -                             -     -                 -                       -     -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 40a · 40b ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b · 46c ^ 47 ^ 48a · 48b · 48c · 48d ^ 49
    SP1:                                                  -     -                                             
    SP2:                                                                                                      
    SP3:                                                  -     -                                             
    SP4:                                                                                                      
    SP5:  -     -                                                                                             


    ECgene alternative splicing isoforms for CIT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CIT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATGGGC
    CIT Expression
    About this image


    CIT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Spinal Cord (Nervous System)
    CIT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CIT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119594
        Pathway & Disease-focused RT2 Profiler PCR Array including CIT: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CIT
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CIT gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cit1 , 5 citron1, 5 89.88(n)1
    96.83(a)1
      5 (56.10 cM)5
    127041  NM_007708.31  NP_031734.31 
     1158452785 
    chicken
    (Gallus gallus)
    Aves CIT1 citron (rho-interacting, serine/threonine kinase 21) 80.18(n)
    90.26(a)
      416984  XM_004934405.1  XP_004934462.1 
    lizard
    (Anolis carolinensis)
    Reptilia CIT6
    citron (rho-interacting, serine/threonine kinase 2...
    88(a)
    1 ↔ 1
    GL343338.1(278336-342914)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119152 Transcribed sequence with moderate similarity to protein more 75.64(n)    BX723780.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI563054.12   -- 76.82(n)    BI563054.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105223
    sti1
    protein amino acid phosphorylation
    protein serine/threonine more3
    sticky1
    30(a)3
    45.49(n)1
    33.52(a)1
      69C43
    394291  NM_001274839.11  NP_001261768.11 


    ENSEMBL Gene Tree for CIT (if available)
    TreeFam Gene Tree for CIT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CIT gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  ROCK12  
    CDC42BPA2  LATS22  ROCK22  
    Selected SIMAP similar genes for CIT using alignment to 4 protein entries:     CTRO_HUMAN (see all proteins) (see all similar genes):
    RPS6KA2    DMPK    RPS6KA3    SGK3    STK38L    PDPK1
    PRKACA    PKN1    PNCK    PRKY    MAST1    PRKAA1
    PRKACB    PRKACG    PRKX    RPS6KB2    AKT3    SGK2

    Find genes that share paralogs with CIT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CIT (see all 4096)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136783221,2
    C--117164066(+) CTTTTC/TTTTTT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs575019011,2
    C--117164070(+) CTTTT-/CTTTT 
     TTT
    /TTT
    TTTTT
    4 -- int1 cds11NA 2
    rs343554351,2
    C--117170056(+) TACAT-/TAAAAAA 2 -- int11Minor allele frequency- TA:0.00NA 2
    rs787447351,2
    C,F--117170056(+) TACATA/TAAAAA 2 -- int14Minor allele frequency- T:0.25WA NA CSA 8
    rs2016322661,2
    C--117172687(+) TGTGTG/TTGTTT 2 -- int10--------
    rs710725641,2
    C--117178148(+) AAAAA-/A/GGAAAA 2 -- int11NA 2
    rs1112599831,2
    C--117189510(+) CCCTGACACA   
       CAC
    /-
    ACACA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs357226851,2
    C--117232987(+) TTTTT-/TCTTGG 2 -- int11Minor allele frequency- T:0.00NA 2
    rs358416351,2
    C--117234853(+) AAAAA-/ACAAAT 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs1398292601,2
    C--117272148(+) TACTG-/TATAT 
     ATATATA
    TATAT
    2 -- int10--------

    HapMap Linkage Disequilibrium report for CIT (120123595 - 120315095 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CIT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1316430CNV Insertion17803354
    nsv510575CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CIT
    DNA2.0 Custom Variant and Variant Library Synthesis for CIT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605629    OMIM disorders: --

    2 diseases for CIT:    
    About MalaCards
    bipolar disorder    schizophrenia


    Find genes that share disorders with CIT           About GenesLikeMe

    Genetic Association Database (GAD): CIT
    Human Genome Epidemiology (HuGE) Navigator: CIT (18 documents)

    Export disorders for CIT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CIT gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with CIT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    4. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)1, 2 Kamijo K....Miki T. (Mol. Biol. Cell 2006)
    5. KIF14 and citron kinase act together to promote efficient cytokinesis. (PubMed id 16431929)1, 2 Gruneberg U.... Barr F.A. (J. Cell Biol. 2006)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    7. Evidence of association between bipolar disorder and Citron on chromosome 12q24. (PubMed id 15983625)1, 2 Lyons-Warren A.... Sawa A. (Mol. Psychiatry 2005)
    8. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    9. Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. (PubMed id 9792683)1, 3 Di Cunto F....Dotto G.P. (J. Biol. Chem. 1998)
    10. Citron kinase mediates transition from constriction to abscission through its coiled-coil domain. (PubMed id 23444367)1 Watanabe S....Narumiya S. (J. Cell. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11113 HGNC: 1985 AceView: CIT Ensembl:ENSG00000122966 euGenes: HUgn11113
    ECgene: CIT H-InvDB: CIT

    (According to HUGE)
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    HUGE: KIAA0949

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CIT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CIT gene:
    Search GeneIP for patents involving CIT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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