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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CISH Gene

protein-coding GIFtS: 60
GCID: GC03M050618

cytokine inducible SH2-containing protein

Explore 48 diseases affiliated with
CISH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytokine Inducible SH2-Containing Protein¹ ²		Suppressor Of Cytokine Signaling² ³
CIS¹ ² ³		BACTS2²
CIS-1¹ ² ³		Cytokine-Inducible Inhibitor Of Signaling Type 1B²
G18¹ ² ³		Cytokine-Inducible SH2-Containing Protein²
SOCS¹ ² ³		Protein G18³

External Ids:	HGNC: 1984¹	Entrez Gene: 1154²	Ensembl: ENSG00000114737⁷	OMIM: 602441⁵	UniProtKB: Q9NSE2³

Export aliases for CISH gene to outside databases

Previous GC identifers: GC03P049337 GC03P049507 GC03M050498 GC03M050602

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CISH:

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the

cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT

inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine

signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells.

Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the

erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal

transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such

as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its

tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box

protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation

of target proteins (By similarity)

Gene Wiki entry for CISH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CISH gene promoter:
STAT5B GR NRSF form 1 GR-beta STAT3 STAT5A GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CISH promoter sequence

Search SABiosciences Chromatin IP Primers for CISH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CISH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21.3

CISH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CISH gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M050618: view genomic region (about GC identifiers)

Start:	50,643,885 bp from pter	End:	50,649,262 bp from pter
Size:	5,378 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2 (See protein sequence)

Recommended Name: Cytokine-inducible SH2-containing protein

Size: 258 amino acids; 28663 Da

Subunit: Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO

receptor (EPOR)

Secondary accessions: B2R9N1 Q9NS38 Q9Y5R1

Alternative splicing: 3 isoforms: Q9NSE2-1 Q9NSE2-2 Q9NSE2-3

Explore the universe of human proteins at neXtProt for CISH: NX_Q9NSE2

Post-translational modifications:

Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is

mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NSE2

CISH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_037456.5 NP_659508.1

ENSEMBL proteins:

ENSP00000409346 ENSP00000294173

Reactome Protein details: Q9NSE2
Human Recombinant Protein Products:

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	Novus Biologicals CISH Proteins Novus Biologicals CISH Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CISH

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	--	--

CISH for ontologies About GeneDecksing

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	Uscn Antibodies for CISH
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	GenScript Custom Assay Services for CISH
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CISH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CISH for domains About GeneDecksing

2 InterPro domains/families:

IPR001496 SOCS_C

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q9NSE2

ProtoNet protein and cluster: Q9NSE2

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB001496 SOCS protein

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SOCS box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal

transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such

as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its

tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box

protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation

of target proteins (By similarity)

Induction: By a subset of cytokines including EPO/erythropoietin

Genatlas biochemistry entry for CISH:

cytokine inducible SH2-containing protein gene,binding to IL3 and EPOR,predominantly expressed in fetal and adult liver

and kidney,negative regulator of the JAK signaling pathway

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CISH Browse MicroRNA Expression Plasmids
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		hsa-miR-485-5p hsa-miR-1266 hsa-miR-944 hsa-miR-3190 hsa-miR-7 hsa-miR-4267 hsa-miR-548m hsa-miR-214*

		SwitchGear 3'UTR luciferase reporter plasmid: CISH 3' UTR sequence

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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CISH
		Search LifeMap BioReagents cell lines for CISH

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISH

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	--	--

CISH for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CISH:

Increased cell number in G1, s

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Development Thrombopoetin signaling via JAK-STAT pathway

	Development_Thrombopoetin signaling via JAK-STAT pathway	1.00			Jak/Stat Pathway	0.29
	Development Thrombopoetin signaling via JAK-STAT pathway	1.00

Development_EPO-induced Jak-STAT pathway

	Development_EPO-induced Jak-STAT pathway	1.00			EPO Receptor Signaling	0.42
	Development EPO-induced Jak-STAT pathway	1.00

IL-9 Signaling Pathways

	Immune response_IL-9 signaling pathway	0.42			IL-9 Pathway	0.22
	Immune response IL-9 signaling pathway	0.42

IL-2 Signaling Pathway

IL-2 Signaling Pathway

1.00

IL2-mediated signaling events

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for CISH

	Immune response IL-9 signaling pathway
	Development EPO-induced Jak-STAT pathway
	Immune response IL-3 activation and signaling pathway
	Immune response IL-2 activation and signaling pathway
	Development Thrombopoetin signaling via JAK-STAT pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CISH

	IL-9 Pathway
	SOCS Pathway

2 Cell Signaling Technology (CST) Pathways for CISH

	Lymphocyte Signaling
	Jak/Stat Pathway

5 GeneGo (Thomson Reuters) Pathways for CISH

	Immune response IL-3 activation and signaling pathway
	Development EPO-induced Jak-STAT pathway
	Immune response IL-9 signaling pathway
	Immune response IL-2 activation and signaling pathway
	Development Thrombopoetin signaling via JAK-STAT pathway

5/9 BioSystems Pathways for CISH (see all 9)

	EPO Receptor Signaling
	MicroRNAs in cardiomyocyte hypertrophy
	Leptin signaling pathway
	IL-3 Signaling Pathway
	Prolactin Signaling Pathway

3 Reactome Pathways for CISH

	Cytokine Signaling in Immune system
	Growth hormone receptor signaling
	Immune System

1 Kegg Pathway (Kegg details for CISH):

Jak-STAT signaling pathway

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Pathway: Protein modification; protein ubiquitination

CISH for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CISH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for CISH (Q9NSE2^{2, 3} ENSP00000409346⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2	P04626²^,³, ENSP00000269571⁴	MINT-74493 MINT-74492 MINT-74494 MINT-74495 I2D: score=1 STRING: ENSP00000269571
SMAD2	Q15796²^,³, ENSP00000262160⁴	MINT-61614 I2D: score=3 STRING: ENSP00000262160
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-74491 I2D: score=1 STRING: ENSP00000275493
GHR	P10912³, ENSP00000230882⁴	I2D: score=3 STRING: ENSP00000230882
IL2RB	P14784³, ENSP00000216223⁴	I2D: score=3 STRING: ENSP00000216223

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	NAS	9465889
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	--	--
GO:0009968	negative regulation of signal transduction	IEA	--
GO:0016567	protein ubiquitination	IEA	--
GO:0019221	cytokine-mediated signaling pathway	--	--

CISH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CISH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CISH
10/21 Novoseek chemical compound relationships for CISH gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	60.2	45	9129017 (3), 7796808 (2), 16033816 (2), 12783885 (2) (see all 32)
skf 96365	56.5	1	19059932 (1)
thapsigargin	53.9	11	12623442 (1), 19059932 (1), 15937149 (1), 18342630 (1) (see all 8)
gp 130	49.9	1	16630890 (1)
5-aza-2'deoxycytidine	47.7	1	15361843 (1)
ifn-alpha	41	6	11340296 (3), 16943383 (1), 18616672 (1)
inositol 1,4,5 trisphosphate	38.2	4	17140548 (1), 20149454 (1), 15138280 (1)
phosphotyrosine	35.1	7	16426581 (2), 16266868 (1), 16630890 (1), 10514520 (1) (see all 5)
calcium	31.8	80	15937149 (5), 15226409 (4), 12765682 (3), 15036949 (3) (see all 29)
ryanodine	23.1	2	19154741 (1)

Search CenterWatch for drugs/clinical trials and news about CISH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CISH gene (2 alternative transcripts):

NM_013324.5 NM_145071.2

Unigene Cluster for CISH:

Cytokine inducible SH2-containing protein

Hs.655334 [show with all ESTs]

Unigene Representative Sequence: NM_013324

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000491847 ENST00000443053(uc010hlq.3) ENST00000348721(uc003dax.3)

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		hsa-miR-485-5p hsa-miR-1266 hsa-miR-944 hsa-miR-3190 hsa-miR-7 hsa-miR-4267 hsa-miR-548m hsa-miR-214*

		SwitchGear 3'UTR luciferase reporter plasmid: CISH 3' UTR sequence

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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CISH

Additional cDNA sequence:

AF132297.2 AK313850.1 BC031590.1 BC064354.1 D83532.1

8 DOTS entries:

DT.412916 DT.100763677 DT.100763676 DT.91750383 DT.95196283 DT.95196284 DT.97789301 DT.100713022

24/111 AceView cDNA sequences (see all 111):

AA353819 BG697340 AW168260 CR594144 BM917119 AI928902 CR602225 D83532

BM923928 BC064354 AW161428 AA427521 AF035947 AA292305 AA581981 AI418915

AI149493 NM_145071 BE936762 AW193835 AW052069 BQ067143 AI917465 BE502526

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CISH About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:
SP2:							-
SP3:							-				-
SP4:							-				-		-
SP5:

ECgene alternative splicing isoforms for CISH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CISH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CISH expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CISH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CISH

SOURCE GeneReport for Unigene cluster: Hs.655334

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Tissue specificity: Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser

extent in lung. The tissue distribution of isoforms 1 and 1B is distinct

SABiosciences Expression via Pathway-Focused PCR Array including CISH:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CISH gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CISH¹	cytokine inducible SH2-containing protein	71.66(n) 70.04(a)		395335 NM_204626.1 NP_989957.1
lizard (Anolis carolinensis)	Reptilia	CISH⁶	--	64(a)	1 ↔ 1	2(151562841-151564832)
zebrafish (Danio rerio)	Actinopterygii	socs8¹	suppressor of cytokine signaling 8	53.93(n) 50.26(a)		100136861 NM_001114554.1 NP_001108026.1
honey bee (Apis mellifera)	Insecta	--	--	33(a)	1 → many	Group8.34(5736-6146)

ENSEMBL Gene Tree for CISH (if available)
TreeFam Gene Tree for CISH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CISH gene

SOCS3² SOCS4² SOCS5² SOCS7² SOCS6² SOCS1² SOCS2²

1 SIMAP similar gene for CISH using alignment to 2 protein entries: CISH_HUMAN (see all proteins):

SOCS2

CISH for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Polymorphism: Note=CISH polymorphisms are involved in susceptibilty to malaria [MIM:611162]

Polymorphism: Note=Genetic variations in CISH are involved in susceptibilty to tuberculosis [MIM:607948]

Polymorphism: Note=Genetic variations in CISH are associated with susceptibility to bacterial invasion of the blood and

define the bacteremia susceptibility locus 2 (BACTS2) [MIM:614383]

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142646565^1,2		--	50643933(+)	`AGGTAC/TCATTT`	2	--	ut3¹		0	--	--	--	--
rs151010021^1,2		--	50644038(+)	`TATAAC/TTATTA`	2	--	ut3¹		0	--	--	--	--
rs140905116^1,2		--	50644080(+)	`CTCCTC/TTCATG`	2	--	ut3¹		0	--	--	--	--
rs175634^1,2	C,F,A,H,	--	50644134(-)	`GGGCCA/GCCACT`	2	--	ut3¹ ese³		32		MN NA NS EA WA CSA	2989
rs144186398^1,2		--	50644135(+)	`GTGGCA/GGCCCT`	2	--	ut3¹		0	--	--	--	--
rs117227840^1,2	C,F,	--	50644343(+)	`GAGTGG/AACACA`	2	--	ut3¹		1		EA	120
rs114038753^1,2	F,	--	50644507(+)	`GGCTCG/ACCCCT`	2	--	ut3¹		1		NA	120
rs186408718^1,2		--	50644605(+)	`AGTCAC/TTGTCG`	2	--	ut3¹		0	--	--	--	--
rs199816251^1,2		--	50645032(+)	`GCCCCA/GTACAG`	2	--	ut3¹		0	--	--	--	--
rs189244040^1,2	C,	--	50645070(+)	`GTAGTC/TGGCCA`	4	N D	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CISH (50643885 - 50649262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CISH: --
Human Gene Mutation Database (HGMD): CISH

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CISH for disorders           About GeneDecksing

OMIM gene information: 602441
OMIM disorders: 607948  611162
20/48 diseases for CISH (see all 48):    About MalaCards

fibrous histiocytoma malignant fibrous histiocytoma severe congenital neutropenia type 2 diabetes mellitus

placental insufficiency myeloproliferative disorder insulin resistance viral hepatitis

histiocytoma systemic lupus erythematosus lupus erythematosus diabetes mellitus

rheumatoid arthritis hepatitis c allergic asthma uveitis

neutropenia asthma nephropathy multiple myeloma

10/37 Novoseek disease relationships for CISH gene (see all 37) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloproliferative disorders	44.5	1	18623127 (1)
asthma allergic	33.7	3	17266577 (1), 16476192 (1)
insulin resistance	32.7	9	11342531 (2), 15072573 (1), 18171427 (1), 17010638 (1) (see all 5)
leukemia	32	5	20372794 (1), 11268394 (1), 19543316 (1), 19159951 (1)
inflammation	28.8	9	19041303 (4), 15081412 (1), 15275643 (1), 15153517 (1) (see all 5)
necrosis	24.6	8	15491991 (1), 15757867 (1), 12475383 (1), 17327369 (1) (see all 7)
tumors	20.2	15	15491991 (1), 15757867 (1), 12475383 (1), 16125365 (1) (see all 14)
cns diseases	17.2	1	14993936 (1)
adenocarcinoma lung	10.9	2	12796816 (2)
prostate cancer	8.53	5	16529812 (1), 12765682 (1), 15138280 (1), 17001312 (1)

Human Genome Epidemiology (HuGE) Navigator: CISH (7 documents)

Export disorders for CISH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CISH gene, integrated from 9 sources (see all 312):
(articles sorted by number of sources associating them with CISH)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues. (PubMed id 9465889)^{1, 2, 3} Uchida K.... Takahashi K. (1997)
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. (PubMed id 7796808)^{1, 3, 9} Yoshimura A....Miyajima A. (1995)
CISH and susceptibility to infectious diseases. (PubMed id 20484391)^{1, 2, 9} Khor C.C....Hill A.V. (2010)
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein. (PubMed id 9774439)^{1, 2, 9} Verdier F.... Mayeux P. (1998)
Cloning and characterization of CIS 1b (cytokine inducible SH2- containing protein 1b), an alternative splicing form of CIS 1 gene. (PubMed id 10902923)^{1, 2, 9} Jiang C.... Zhao S. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
cDNA representational difference analysis of human neutrophils stimulated by GM-CSF. (PubMed id 11032736)^{1, 2} Yousefi S.... Jarai G. (2000)
Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. (PubMed id 10517496)^{1, 9} Okabe S....Ohyashiki K. (1999)
CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling. (PubMed id 10514520)^{1, 9} Aman M.J....Leonard W.J. (1999)
MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbi al challenge. (PubMed id 19592657)^{1, 9} Hu G....Chen X.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1154	HGNC: 1984	AceView: CISH	Ensembl:ENSG00000114737	euGenes: HUgn1154
ECgene: CISH	Kegg: 1154	H-InvDB: CISH

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CISH	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CISH gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CISH gene:
Search GeneIP for patents involving CISH

GeneCards and IP:
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cytokine inducible SH2-containing protein

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cytokine inducible SH2-containing protein

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