V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CISH Gene

protein-coding GIFtS: 60

GC03M050618

cytokine inducible SH2-containing protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CIS ^¹, ², ³
CIS-1 ^¹, ², ³
G18 ^¹, ², ³
SOCS ^¹, ², ³

Descriptions
Protein G18 ^³
Suppressor of cytokine signaling ^², ³
cytokine inducible SH2-containing protein ^²
cytokine-inducible SH2-containing protein ^²
cytokine-inducible inhibitor of signaling type 1B ^²

External Ids
HGNC: 1984¹
Entrez Gene: 1154²
UniProtKB: Q9NSE2³
Ensembl: ENSG00000114737⁷

Search outside databases for aliases for CISH gene

Previous GC identifers: GC03P049337 GC03P049507 GC03M050498 GC03M050602

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CISH:

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus

belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine

signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are

known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this

gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated

degradation of this protein has been shown to be involved in the inactivation of the

erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found

for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Function: SOCS family proteins form part of a classical negative feedback system that regulates

cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal

through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor.

Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a

substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3

ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal

degradation of target proteins (By similarity)

Gene Wiki entry for CISH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CISH gene

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

CISH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M050618: (about GC identifiers)

Start:	50,618,924 bp from pter
End:	50,624,207 bp from pter
Size:	5,284 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2 (See protein sequence)

Recommended Name: Cytokine-inducible SH2-containing protein

Size: 258 amino acids; 28663 Da

Subunit: Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and

tyrosine-phosphorylated EPO receptor (EPOR)

Secondary accessions: Q9NS38 Q9Y5R1

Alternative splicing: 3 isoforms: Q9NSE2-1 Q9NSE2-2 Q9NSE2-3

Post-translational modifications:

Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome

pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated

form (45 kDa)¹

REFSEQ proteins (2 alternative transcripts):

NP_037456.5 NP_659508.1

ENSEMBL proteins:

ENSP00000294173

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CISH)
	Human Recombinant Proteins from Abnova (CISH)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for CISH:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CISH
	R&D Systems Antibodies for CISH (CIS-1)
	Antibodies from Abcam (CISH), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CISH)
	Novus Biologicals Antibodies for CISH

Assays for CISH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NSE2

ProtoNet protein and cluster: Q9NSE2

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB001496 SOCS protein

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SOCS box domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CISH)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_013324

Applied Biosystems Silencer® siRNAs for CISH

Sigma-Aldrich siRNA and siRNA Panels for CISH

Sigma-Aldrich shRNA Panels and shRNA for CISH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CISH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_013324
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_013324
untagged cDNA clones in CMV expression vector (see all 2): NM_013324

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013324

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Function: SOCS family proteins form part of a classical negative feedback system that regulates

cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal

through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor.

Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a

substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3

ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal

degradation of target proteins (By similarity)

Induction: By a subset of cytokines including erythropoietin (EPO)

Genatlas biochemistry entry for CISH:

cytokine inducible SH2-containing protein gene,binding to IL3 and EPOR,predominantly expressed in

fetal and adult liver and kidney,negative regulator of the JAK signaling pathway

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for CISH (Your Favorite Gene powered by Ingenuity)

GM-CSF Signaling
IL-9 Signaling
JAK/Stat Signaling

GeneDecks CISH for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for CISH

3 Interacting proteins for CISH (Q9NSE2²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2	P04626²	MINT-74493 MINT-74492 MINT-74494 MINT-74495
EGFR	P00533²	MINT-74491
SMAD2	Q15796²	MINT-61614

About this table
5 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 9465889
GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway IEA --
GO:0007242 intracellular signaling cascade NAS 10902923
GO:0009968 negative regulation of signal transduction IEA --
GO:0019941 modification-dependent protein catabolic process IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CISH
10/15 Novoseek chemical compound relationships for CISH gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	61.44	44	9129017 (3), 7796808 (2), 16033816 (2), 12783885 (2) (see all 31)
gp 130	51.66	1	16630890 (1)
ifn-alpha	43.50	6	11340296 (3), 16943383 (1), 18616672 (1)
phosphotyrosine	36.91	7	16426581 (2), 16266868 (1), 16630890 (1), 10514520 (1) (see all 5)
inositol 1,4,5 trisphosphate	34.12	2	17140548 (1), 15138280 (1)
calcium	25.83	67	15937149 (5), 15226409 (4), 12765682 (3), 15036949 (3) (see all 23)
ryanodine	25.34	2	19154741 (1)
lipid	2.46	1	15654916 (1)
phosphoinositide	0.00	2	17142110 (1), 12379181 (1)
lysine	0.00	1	15899873 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CISH)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_013324

Sigma-Aldrich siRNA and siRNA Panels for CISH

Sigma-Aldrich shRNA Panels and shRNA for CISH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_013324 NM_145071

REFSEQ mRNAs for CISH gene (2 alternative transcripts):

NM_013324.5 NM_145071.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_013324 NM_145071

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_013324
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_013324
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_013324

Additional cDNA sequence:

AF132297.2 AK313850.1 BC031590.1 BC064354.1 CR594144.1 CR602225.1 D83532.1

8 DOTS entries:

DT.412916 DT.100763677 DT.100763676 DT.91750383 DT.95196283 DT.95196284 DT.97789301 DT.100713022

24/111 AceView cDNA sequences (see all 111 ):

AW168260 BM923928 AA292305 BG697340 AA427521 CR602225 BC064354 BM917119

AA353819 CR594144 AI928902 AF035947 AW161428 D83532 AI929155 AI917465

AW950888 BM906736 BU634403 BM923316 BQ067143 T40564 AL569851 BI760507

highest scoring ESTs for CISH:

AF132297 AI929155 AL543247 AL546401 AW052069 AW161428 BC031590 BC064354 BG697340 BI759267

Unigene Cluster for CISH:

Cytokine inducible SH2-containing protein

Hs.655334 [show with all ESTs]

Unigene Representative Sequence: NM_013324

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CISH

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:
SP2:							-
SP3:							-				-
SP4:							-				-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for CISH

1 Ensembl transcript including schematic representation:

ENST00000348721

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CISH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CISH

¹ / ² / ³

7 probe-sets matching CISH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55059_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	AW052069	0.80	1.00	0.91	1
221223_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_013324	0.20	1.00	0.72	1
223377_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF035947	0.60	1.00	0.82	1
223961_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	D83532	0.80	1.00	0.91	1
221223_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223377_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223961_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CISH for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.655334
UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2
Tissue specificity: Expressed in various epithelial tissues. Abundantly expressed in liver and
kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CISH gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CISH¹	--	cytokine inducible SH2-containing protein	89.33(n) 90.8(a)	484757 XM_541873.2 XP_541873.2
chimpanzee (Pan troglodytes)	CISH¹	--	cytokine inducible SH2-containing protein	99.73(n) 99.6(a)	470819 XM_526202.2 XP_526202.2
cow (Bos taurus)	CISH¹	--	cytokine inducible SH2-containing protein	87.93(n) 91.34(a)	616753 NM_001046586.1 NP_001040051.1
rat (Rattus norvegicus)	Cish¹	--	cytokine inducible SH2-containing protein	86.12(n) 91.05(a)	83681 XM_343472.3 XP_343473.3
mouse (Mus musculus)	Cish^{1, 5}	9 (59.00 cM)⁵	cytokine inducible SH2-containing protein^{1, 5}	86.25(n)¹ 91.05(a)¹	12700¹ NM_009895.3¹ NP_034025.1¹ AI385595⁵ AK077338⁵ (see all 16)

About this table Species with no ortholog for CISH

ENSEMBL Gene Tree for CISH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CISH gene

SOCS7² SOCS6² SOCS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/42 NCBI SNPs in CISH are shown (see all 42 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs175634^1,2	A,C,F,H	50619138(-)	`GGGCCA/GCCACT`	2	--	ut3¹ ese³		12		MN NA EU EA WA	1158
	rs809451^1,2	A,C,F,H	50625896(-)	`TCCCCG/CCTACC`	1	--	ng3¹		6		NA EA EU	550
--	rs414171^1,2	C,F,H	50624503(-)	`ACCGCA/TCGGCT`	1	--	ng3¹		7		EA NA MN EU	538
	rs2239751^1,2	C,F,H	50622892(-)	`CTCCAA/CAGCGG`	2	--	int¹ ut5¹ ese³		12		EA NA EU WA	2218
	rs6768300^1,2	C	50624374(+)	`GTGCGC/GGGGCC`	1	--	ng3¹		0	--	--	--	--
	rs2239752^1,2	C,F,H	50620417(-)	`TATGCC/TGACTC`	2	A/A	syn¹ ese³		12		EA NA EU WA	2420
	rs2239753^1,2	C,F,H	50620162(-)	`AGCAGT/CGCCCG`	2	S/S	syn¹ ese³		6		EA EU WA NA	1950
--	rs1872184^1,2	A,C,F	50622347(+)	`GCAAAC/TAGCGC`	1	--	int¹		4		NA EA	362
--	rs17051027^1,2	F	50622438(+)	`GACCCT/GCTAGG`	1	--	int¹ ese³		3		NA	142
	rs621975^1,2	C	50620639(+)	`TCCAGG/TGCAAG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CISH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602441

UniProtKB/Swiss-Prot: CISH_HUMAN, Q9NSE2

CISH deletion may be involved in the pathogenesis of renal cell carcinomas and of lung

cancer since lung and kidney tumors frequently exhibit 3p21.3 deletions

10/35 Novoseek disease relationships for CISH gene (see all 35 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloproliferative disorders	43.33	1	18623127 (1)
insulin resistance	32.43	9	11342531 (2), 15072573 (1), 18171427 (1), 17010638 (1) (see all 5)
asthma allergic	31.75	3	17266577 (1), 16476192 (1)
leukemia	28.51	2	11268394 (1)
necrosis	25.13	8	15491991 (1), 15757867 (1), 12475383 (1), 17327369 (1) (see all 7)
inflammation	24.26	9	19041303 (4), 15081412 (1), 15275643 (1), 15153517 (1) (see all 5)
tumors	20.53	15	15491991 (1), 15757867 (1), 12475383 (1), 16125365 (1) (see all 14)
cns diseases	20.23	1	14993936 (1)
adenocarcinoma lung	14.29	2	12796816 (2)
prostate cancer	8.83	5	16529812 (1), 12765682 (1), 15138280 (1), 17001312 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

European Commission Approves Further Diagnostic Testing Methods for Determining Eligibility of Patients for Herceptin (Trastuzumab)

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/285 PubMed articles for CISH gene (see all 285 ):

Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues. (PubMed id 9465889)^{2, 3, 4} Uchida K.... Takahashi K. (1997)
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. (PubMed id 7796808)^{1, 2, 3} Yoshimura A....Miyajima A. (1995)
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein. (PubMed id 9774439)^{1, 3, 4} Verdier F.... Mayeux P. (1998)
Cloning and characterization of CIS 1b (cytokine inducible SH2- containing protein 1b), an alternative splicing form of CIS 1 gene. (PubMed id 10902923)^{1, 3, 4} Jiang C.... Zhao S. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
cDNA representational difference analysis of human neutrophils stimulated by GM-CSF. (PubMed id 11032736)^{3, 4} Yousefi S.... Jarai G. (2000)
Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. (PubMed id 10517496)^{1, 3} Okabe S....Ohyashiki K. (1999)
CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling. (PubMed id 10514520)^{1, 3} Aman M.J....Leonard W.J. (1999)
Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor. (PubMed id 11713228)^{1, 3} Dif F....Edery M. (2001)
The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. (PubMed id 18820827)^{1, 3} Tsao J.T....Lin S.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1154	HGNC: 1984	AceView: CISH	Ensembl:ENSG00000114737	euGenes: HUgn1154
ECgene: CISH	H-InvDB: CISH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CISH
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CISH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CISH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CISH		Antibodies for CISH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CISH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CISH)
	Antibodies (CISH)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CISH)
	Antibodies (CISH)

Search OriGene for CISH

Search Tocris compounds for CISH

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CISH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CISH Gene at Home site.
Version 2.41.1
server4.xennexinc.com

CISH Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for CISH

Summaries
for CISH

Genomic Location
for CISH

Proteins
for CISH

Protein Domains/
Families
for CISH

Gene Function
for CISH

Pathways & Interactions
for CISH

Drugs & Compounds
for CISH

Transcripts
for CISH

Expression
for CISH

Orthologs
for CISH

Paralogs
for CISH

SNPs/Variants
for CISH

Disorders & Mutations
for CISH

Medical News
for CISH

Publications
for CISH

Search for CISH

Genome Databases showing CISH

Other Databases showing CISH

Specialized Databases showing CISH

Licensable Technologies
for CISH

Services
for CISH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CISH Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor CISH

Summariesfor CISH

Genomic Locationfor CISH

Proteinsfor CISH

Protein Domains/Familiesfor CISH

Gene Functionfor CISH

Pathways & Interactionsfor CISH

Drugs & Compoundsfor CISH

Transcriptsfor CISH

Expression for CISH

Orthologsfor CISH

Paralogsfor CISH

SNPs/Variantsfor CISH

Disorders & Mutationsfor CISH

Medical Newsfor CISH

Publicationsfor CISH

Search for CISH

Genome Databases showing CISH

Other Databases showing CISH

Specialized Databases showing CISH

Licensable Technologiesfor CISH

Servicesfor CISH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CISH

Summaries
for CISH

Genomic Location
for CISH

Proteins
for CISH

Protein Domains/
Families
for CISH

Gene Function
for CISH

Pathways & Interactions
for CISH

Drugs & Compounds
for CISH

Transcripts
for CISH

Expression
for CISH

Orthologs
for CISH

Paralogs
for CISH

SNPs/Variants
for CISH

Disorders & Mutations
for CISH

Medical News
for CISH

Publications
for CISH

Licensable Technologies
for CISH

Services
for CISH