Aliases for CISH Gene
External Ids for CISH Gene
Previous GeneCards Identifiers for CISH Gene
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for CISH Gene
CISH (Cytokine Inducible SH2 Containing Protein) is a Protein Coding gene. Diseases associated with CISH include Bacteremia and Mycobacterium Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Protection Against, Included. Among its related pathways are Immune System and TSLP Signaling Pathway. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS2.
UniProtKB/Swiss-Prot for CISH Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).