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Aliases for CISH Gene

Aliases for CISH Gene

  • Cytokine Inducible SH2-Containing Protein 2 3
  • Suppressor Of Cytokine Signaling 3 4
  • BACTS2 3 6
  • CIS-1 3 4
  • SOCS 3 4
  • CIS 3 4
  • G18 3 4
  • Cytokine-Inducible Inhibitor Of Signaling Type 1B 3
  • Cytokine-Inducible SH2-Containing Protein 3
  • Protein G18 4

External Ids for CISH Gene

Summaries for CISH Gene

Entrez Gene Summary for CISH Gene

  • The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for CISH Gene

CISH (Cytokine Inducible SH2-Containing Protein) is a Protein Coding gene. Diseases associated with CISH include bacteremia and placental insufficiency. Among its related pathways are TGF-Beta Pathway and Kit Receptor Signaling Pathway. An important paralog of this gene is SOCS2.

UniProtKB/Swiss-Prot for CISH Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene Wiki entry for CISH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CISH Gene

Genomics for CISH Gene

Genomic Location for CISH Gene

Start:
50,606,454 bp from pter
End:
50,611,831 bp from pter
Size:
5,378 bases
Orientation:
Minus strand

Genomic View for CISH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CISH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CISH Gene

Regulatory Elements for CISH Gene

Proteins for CISH Gene

  • Protein details for CISH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSE2-CISH_HUMAN
    Recommended name:
    Cytokine-inducible SH2-containing protein
    Protein Accession:
    Q9NSE2
    Secondary Accessions:
    • B2R9N1
    • G5E9R1
    • Q9NS38
    • Q9Y5R1

    Protein attributes for CISH Gene

    Size:
    258 amino acids
    Molecular mass:
    28663 Da
    Quaternary structure:
    • Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR)
    SequenceCaution:
    • Sequence=AAD28471.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CISH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CISH Gene

Proteomics data for CISH Gene at MOPED

Post-translational modifications for CISH Gene

  • Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CISH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CISH Gene

Domains for CISH Gene

Gene Families for CISH Gene

HGNC:
  • SH2D :SH2 domain containing
  • SOCS :Suppressors of cytokine signaling

Protein Domains for CISH Gene

Suggested Antigen Peptide Sequences for CISH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSE2

UniProtKB/Swiss-Prot:

CISH_HUMAN
Domain:
  • Contains 1 SH2 domain.:
    • Q9NSE2
  • Contains 1 SOCS box domain.:
    • Q9NSE2
genes like me logo Genes that share domains with CISH: view

Function for CISH Gene

Molecular function for CISH Gene

GENATLAS Biochemistry: cytokine inducible SH2-containing protein gene,binding to IL3 and EPOR,predominantly expressed in fetal and adult liver and kidney,negative regulator of the JAK signaling pathway
UniProtKB/Swiss-Prot Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
UniProtKB/Swiss-Prot Induction: By a subset of cytokines including EPO/erythropoietin

Gene Ontology (GO) - Molecular Function for CISH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with CISH: view
genes like me logo Genes that share phenotypes with CISH: view

Animal Models for CISH Gene

MGI Knock Outs for CISH:

miRNA for CISH Gene

miRTarBase miRNAs that target CISH

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CISH Gene

Localization for CISH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CISH Gene COMPARTMENTS Subcellular localization image for CISH gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CISH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CISH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CISH Gene

Pathways for CISH Gene

genes like me logo Genes that share pathways with CISH: view

UniProtKB/Swiss-Prot Q9NSE2-CISH_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CISH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 9465889
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with CISH: view

Compounds for CISH Gene

(21) Novoseek inferred chemical compound relationships for CISH Gene

Compound -log(P) Hits PubMed IDs
tyrosine 60.2 38
skf 96365 56.5 1
thapsigargin 53.9 8
gp 130 49.9 1
5-aza-2deoxycytidine 47.7 1
genes like me logo Genes that share compounds with CISH: view

Transcripts for CISH Gene

Unigene Clusters for CISH Gene

Cytokine inducible SH2-containing protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CISH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CISH Gene

GeneLoc Exon Structure for
CISH
ECgene alternative splicing isoforms for
CISH

Expression for CISH Gene

mRNA expression in normal human tissues for CISH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CISH Gene

This gene is overexpressed in Liver (5.1) and Kidney - Cortex (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CISH Gene

SOURCE GeneReport for Unigene cluster for CISH Gene Hs.655334

mRNA Expression by UniProt/SwissProt for CISH Gene

Q9NSE2-CISH_HUMAN
Tissue specificity: Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.
genes like me logo Genes that share expressions with CISH: view

Orthologs for CISH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CISH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CISH 35
  • 99.74 (n)
  • 99.61 (a)
CISH 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CISH 35
  • 87.93 (n)
  • 91.34 (a)
CISH 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CISH 35
  • 89.23 (n)
  • 90.66 (a)
CISH 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cish 35
  • 84.82 (n)
  • 88.72 (a)
Cish 16
Cish 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CISH 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CISH 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cish 35
  • 84.57 (n)
  • 88.72 (a)
chicken
(Gallus gallus)
Aves CISH 35
  • 71.26 (n)
  • 69.64 (a)
CISH 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CISH 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cish 35
  • 60.85 (n)
  • 59.91 (a)
zebrafish
(Danio rerio)
Actinopterygii cish 36
  • 43 (a)
OneToMany
cishb 35
  • 53.93 (n)
  • 50.26 (a)
cishb 36
  • 42 (a)
OneToMany
Species with no ortholog for CISH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CISH Gene

ENSEMBL:
Gene Tree for CISH (if available)
TreeFam:
Gene Tree for CISH (if available)

Paralogs for CISH Gene

Paralogs for CISH Gene

Selected SIMAP similar genes for CISH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CISH: view

Variants for CISH Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CISH Gene

Q9NSE2-CISH_HUMAN
Note=CISH polymorphisms are involved in susceptibilty to malaria [MIM:611162]

Sequence variations from dbSNP and Humsavar for CISH Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs175634 -- 50,606,703(-) GGGCC(A/G)CCACT utr-variant-3-prime
rs189927 -- 50,606,195(-) TGGCA(C/G)AGGTG downstream-variant-500B
rs191846 -- 50,606,209(-) GGCTC(G/T)GGGGA downstream-variant-500B
rs371715 -- 50,607,809(+) CACTA(G/T)GCGCA missense, reference
rs400461 -- 50,606,223(-) CACTG(C/T)CAGGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CISH Gene

Variant ID Type Subtype PubMed ID
nsv460533 CNV Loss 19166990
nsv508919 CNV Insertion 20534489
nsv482083 CNV Gain 20164927

Relevant External Links for CISH Gene

HapMap Linkage Disequilibrium report
CISH
Human Gene Mutation Database (HGMD)
CISH

Disorders for CISH Gene

(3) OMIM Diseases for CISH Gene (602441)

(37) Novoseek inferred disease relationships for CISH Gene

Disease -log(P) Hits PubMed IDs
myeloproliferative disorders 44.5 1
asthma allergic 33.7 2
insulin resistance 32.7 6
leukemia 32 4
inflammation 28.8 8

Relevant External Links for CISH

Genetic Association Database (GAD)
CISH
Human Genome Epidemiology (HuGE) Navigator
CISH
genes like me logo Genes that share disorders with CISH: view

No data available for UniProtKB/Swiss-Prot for CISH Gene

Publications for CISH Gene

  1. CISH and susceptibility to infectious diseases. (PMID: 20484391) Khor C.C. … Hill A.V. (N. Engl. J. Med. 2010) 3 4 23 48
  2. Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues. (PMID: 9465889) Uchida K. … Takahashi K. (Cytogenet. Cell Genet. 1997) 2 3 4
  3. Cloning and characterization of CIS 1b (cytokine inducible SH2- containing protein 1b), an alternative splicing form of CIS 1 gene. (PMID: 10902923) Jiang C. … Zhao S. (DNA Seq. 2000) 3 4 23
  4. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. (PMID: 7796808) Yoshimura A. … Miyajima A. (EMBO J. 1995) 2 3 23
  5. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein. (PMID: 9774439) Verdier F. … Mayeux P. (J. Biol. Chem. 1998) 3 4 23

Products for CISH Gene

Sources for CISH Gene

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