CISD3 Gene
protein-coding GIFtS: 35
GCID: GC17P036886
|
|
CDGSH iron sulfur domain 3
| |
Aliases
for CISD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CDGSH Iron Sulfur Domain 31 2 | | CDGSH Iron-Sulfur Domain-Containing Protein 3, Mitochondrial2 | | Miner21 2 3 | | MitoNEET Related 22 | | MitoNEET-Related Protein 22 3 | | MINER25 | | CDGSH Iron Sulfur Domain-Containing Protein 3, Mitochondrial2 | | |
Export aliases for CISD3 gene to outside databasesPrevious GC identifers: GC17U900840 GC17P034138 GC17P032655 |
Summaries
for CISD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CISD3:
CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport andoxidative phosphorylation (Wiley et al., 2007 (PubMed 17376863)).(supplied by OMIM, Apr 2008)
|
Genomic Views
for CISD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CISD3 gene promoter:
HOXA9 HOXA9B NF-1 GATA-3 Pax-5 NRSF form 1 ZIC2/Zic2 NRSF form 2 Meis-1b Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CISD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CISD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12CISD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P036886: view genomic region
(about GC identifiers)
Start:
|
36,886,488 bp from pter |
End:
|
36,891,858 bp from pter |
Size:
|
5,371 bases |
Orientation:
|
plus strand |
|
Proteins
for CISD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CISD3_HUMAN, P0C7P0 (See
protein sequence)Recommended Name: CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor Size: 127 amino acids; 14216 Da
Cofactor: Binds 2 2Fe-2S clusters per subunit (Probable)
Subcellular location: MitochondrionExplore the universe of human proteins at neXtProt for CISD3: NX_P0C7P0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C7P0
CISD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001129970.1
ENSEMBL proteins: ENSP00000391402
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
CISD3 for ontologies About GeneDecksing
CISD3 Antibody Products:
Assay Products for CISD3: |
Protein
Domains /
Families
for CISD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CISD3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0C7P0ProtoNet protein and cluster: P0C7P0 UniProtKB/Swiss-Prot: CISD3_HUMAN, P0C7P0Similarity: Belongs to the CISD protein family |
Function
for CISD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CISD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CISD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CISD3 (NM_001136498) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CISD3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CISD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISD3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- | | GO:0051537 | 2 iron, 2 sulfur cluster binding |
IEA | -- |
CISD3 for ontologies About GeneDecksing
|
Pathways & Interactions
for CISD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CISD3
|
Drugs & Compounds
for CISD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CISD3
Search CenterWatch for drugs/clinical trials and news about CISD3
|
Transcripts
for CISD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CISD3 gene: NM_001136498.1 Unigene Cluster for CISD3: CDGSH iron sulfur domain 3 Hs.713595 [show with all ESTs]Unigene Representative Sequence: NM_0011364983 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000439660(uc010wds.1) ENST00000578573 ENST00000581668
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CISD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CISD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CISD3 (NM_001136498) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CISD3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CISD3 |
Additional cDNA sequence: AK097047.1 AK098433.1 BC062294.1 10 DOTS entries: DT.452567 DT.100789548 DT.91742686 DT.95157095 DT.95157091 DT.95152439 DT.95273344 DT.120957762 DT.97864503 DT.100696256 24/55 AceView cDNA sequences (see all 55): CR621383 AK097047 BM927768 BM546511 AA677676 AK098433 BX421225 BQ219085 BM794297 AI078424 BQ961946 C04332 BC062294 CD674522 BM553995 F31376 AI660550 BG714133 F36956 BU539503 AI749171 AL523749 BM452561 BI827547
GeneLoc Exon Structure
|
Expression
for CISD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CISD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAAGAAT
About this image
See CISD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CISD3
SOURCE GeneReport for Unigene cluster: Hs.713595
SABiosciences Custom PCR Arrays for CISD3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CISD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CISD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CISD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CISD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISD3 |
Orthologs
for CISD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CISD3 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for CISD3 (if available)
TreeFam Gene Tree for CISD3 (if available) |
Paralogs
for CISD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CISD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CISD3 (36886488 - 36891858 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CISD3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CISD3 |
|
Disorders
/ Diseases
for CISD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CISD3 for disorders About GeneDecksing
OMIM gene information: 611933
OMIM disorders: --
1  disease for CISD3: About MalaCardsmalaria
Export disorders for CISD3 gene to outside databases
|
Publications
for CISD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CISD3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CISD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. (PubMed id 17376863)1, 2, 3 Wiley S.E.... Dixon J.E. (2007)
- The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. (PubMed id 17584744)1, 3 Wiley S.E....Dixon J.E. (2007)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CISD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CISD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CISD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CISD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CISD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CISD3 gene:
Search GeneIP for patents involving CISD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CISD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CISD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CISD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CISD3 | | | OriGene Protein Over-expression Lysate for CISD3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CISD3 | | OriGene 3'-UTR Clone for CISD3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CISD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CISD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CISD3 | | OriGene Custom Protein Services for CISD3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CISD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CISD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CISD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CISD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CISD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CISD3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CISD3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CISD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISD3 |
|  |  |  | | | | Search ThermoFisher Antibodies for CISD3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CISD3 |
|
|
|
|
