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Aliases for CISD3 Gene

Aliases for CISD3 Gene

  • CDGSH Iron Sulfur Domain 3 2 3
  • MitoNEET-Related Protein 2 3 4
  • MitoNEET Related 2 2 3
  • Miner2 3 4
  • CDGSH Iron Sulfur Domain-Containing Protein 3, Mitochondrial 3

External Ids for CISD3 Gene

Previous GeneCards Identifiers for CISD3 Gene

  • GC17U900840
  • GC17P034138
  • GC17P036886
  • GC17P032655

Summaries for CISD3 Gene

Entrez Gene Summary for CISD3 Gene

  • CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]

GeneCards Summary for CISD3 Gene

CISD3 (CDGSH Iron Sulfur Domain 3) is a Protein Coding gene. GO annotations related to this gene include 2 iron, 2 sulfur cluster binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CISD3 Gene

Genomics for CISD3 Gene

Regulatory Elements for CISD3 Gene

Genomic Location for CISD3 Gene

38,730,235 bp from pter
38,735,605 bp from pter
5,371 bases
Plus strand

Genomic View for CISD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CISD3 Gene

Proteins for CISD3 Gene

  • Protein details for CISD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CDGSH iron-sulfur domain-containing protein 3, mitochondrial
    Protein Accession:

    Protein attributes for CISD3 Gene

    127 amino acids
    Molecular mass:
    14216 Da
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Note=Binds 2 [2Fe-2S] clusters per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for CISD3 Gene

Proteomics data for CISD3 Gene at MOPED

Post-translational modifications for CISD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CISD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CISD3 Gene

Domains & Families for CISD3 Gene

Gene Families for CISD3 Gene

Protein Domains for CISD3 Gene

Suggested Antigen Peptide Sequences for CISD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CISD protein family.
  • Belongs to the CISD protein family.
genes like me logo Genes that share domains with CISD3: view

Function for CISD3 Gene

Gene Ontology (GO) - Molecular Function for CISD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with CISD3: view

Phenotypes for CISD3 Gene

GenomeRNAi human phenotypes for CISD3:
genes like me logo Genes that share phenotypes with CISD3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CISD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CISD3 Gene

Localization for CISD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CISD3 Gene


Subcellular locations from

Jensen Localization Image for CISD3 Gene COMPARTMENTS Subcellular localization image for CISD3 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for CISD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with CISD3: view

Pathways & Interactions for CISD3 Gene

SuperPathways for CISD3 Gene

No Data Available

Interacting Proteins for CISD3 Gene

Gene Ontology (GO) - Biological Process for CISD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CISD3 Gene

Drugs & Compounds for CISD3 Gene

No Compound Related Data Available

Transcripts for CISD3 Gene

mRNA/cDNA for CISD3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CISD3 Gene

CDGSH iron sulfur domain 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CISD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CISD3 Gene

No ASD Table

Relevant External Links for CISD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CISD3 Gene

mRNA expression in normal human tissues for CISD3 Gene

mRNA differential expression in normal tissues according to GTEx for CISD3 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for CISD3 Gene

This gene is overexpressed in Liver (19.5) and Adrenal (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CISD3 Gene

SOURCE GeneReport for Unigene cluster for CISD3 Gene Hs.713595

genes like me logo Genes that share expression patterns with CISD3: view

Protein tissue co-expression partners for CISD3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CISD3 Gene

Orthologs for CISD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CISD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CISD3 35
  • 87.63 (n)
  • 85.48 (a)
(Canis familiaris)
Mammalia CISD3 35
  • 85.04 (n)
  • 83.46 (a)
(Mus musculus)
Mammalia Cisd3 35
  • 85.98 (n)
  • 87.85 (a)
Cisd3 16
(Pan troglodytes)
Mammalia CISD3 35
  • 99.21 (n)
  • 98.43 (a)
Species with no ortholog for CISD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CISD3 Gene

Gene Tree for CISD3 (if available)
Gene Tree for CISD3 (if available)

Paralogs for CISD3 Gene

No data available for Paralogs for CISD3 Gene

Variants for CISD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CISD3 Gene

Variant ID Type Subtype PubMed ID
nsv833438 CNV Loss 17160897
nsv908196 CNV Loss 21882294
dgv3160n71 CNV Loss 21882294
nsv470585 CNV Loss 18288195

Variation tolerance for CISD3 Gene

Gene Damage Index Score: 7.38; 81.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CISD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CISD3 Gene

Disorders for CISD3 Gene

Relevant External Links for CISD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CISD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CISD3 Gene

Publications for CISD3 Gene

  1. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. (PMID: 17376863) Wiley S.E. … Dixon J.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 67
  2. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. (PMID: 17584744) Wiley S.E. … Dixon J.E. (J. Biol. Chem. 2007) 2 67
  3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 67
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for CISD3 Gene

Sources for CISD3 Gene

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