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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CISD2 Gene

protein-coding   GIFtS: 50
GCID: GC04P103790

CDGSH Iron Sulfur Domain 2

(Previous names: zinc finger, CDGSH-type domain 2, Wolfram syndrome 2)
(Previous symbols: ZCD2, WFS2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CDGSH Iron Sulfur Domain 21 2     Nutrient-Deprivation Autophagy Factor-12 3
ZCD21 2 3 5     Miner12 3
Endoplasmic Reticulum Intermembrane Small Protein1 2 3     NAF-12 3
WFS21 2 5     MitoNEET Related 11
ERIS2 3 5     Wolfram Syndrome 21
Zinc Finger, CDGSH-Type Domain 21 2     CDGSH Iron-Sulfur Domain-Containing Protein 22
MitoNEET-Related 1 Protein2 3     CDGSH23

External Ids:    HGNC: 242121   Entrez Gene: 4938562   Ensembl: ENSG000001453547   OMIM: 6115075   UniProtKB: Q8N5K13   

Export aliases for CISD2 gene to outside databases

Previous GC identifers: GC04P104010 GC04P099526


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CISD2 Gene:
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded
protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause
of Wolfram syndrome 2. (provided by RefSeq, Mar 2011)

GeneCards Summary for CISD2 Gene: 
CISD2 (CDGSH iron sulfur domain 2) is a protein-coding gene. Diseases associated with CISD2 include wolfram syndrome 2, and wolfram syndrome. GO annotations related to this gene include 2 iron, 2 sulfur cluster binding and protein homodimerization activity. An important paralog of this gene is CISD1.

UniProtKB/Swiss-Prot: CISD2_HUMAN, Q8N5K1
Function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the
endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated
depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while
it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its
function as regulator of autophagy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CISD2 gene promoter:
         USF1   NF-E2 p45   CREB   E2F-1   E2F   HSF2   USF-1   deltaCREB   MRF-2   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCISD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CISD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CISD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

CISD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CISD2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P103790:  view genomic region     (about GC identifiers)

Start:
103,790,135 bp from pter      End:
103,813,964 bp from pter
Size:
23,830 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CISD2_HUMAN, Q8N5K1 (See protein sequence)
Recommended Name: CDGSH iron-sulfur domain-containing protein 2  
Size: 135 amino acids; 15278 Da
Cofactor: Binds 1 2Fe-2S cluster
Subunit: Homodimer. Interacts with BCL2; the interaction is direct and disrupted by BIK interaction with BCL2.
Interacts with BCL2L1. Interacts with ITPR1
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane;
Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic
reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane
Caution: Although initially thought (PubMed:17846994) to be a zinc-finger protein, it was later shown
(PubMed:17376863) that it binds 1 2Fe-2S cluster instead
Sequence caution: Sequence=CAD97935.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CISD2:
3FNV (3D)    
Secondary accessions: Q7Z3D5

Explore the universe of human proteins at neXtProt for CISD2: NX_Q8N5K1

Explore proteomics data for CISD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N5K1

  • CISD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CISD2 Protein Expression
    REFSEQ proteins: NP_001008389.1  
    ENSEMBL proteins: 
     ENSP00000273986   ENSP00000458976   ENSP00000423716  

    Human Recombinant Protein Products for CISD2: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CISD2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane ISS--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IDA--
    GO:0016021integral to membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    CISD2 for ontologies           About GeneDecksing



    CISD2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for CISD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CISD: CDGSH iron sulfur domain containing

    3 InterPro protein domains:
     IPR006622 FeS-contain_CDGSH-typ_subfam
     IPR019610 FeS-contain_mitoNEET_N
     IPR018967 FeS-contain_CDGSH-typ

    Graphical View of Domain Structure for InterPro Entry Q8N5K1

    ProtoNet protein and cluster: Q8N5K1

    UniProtKB/Swiss-Prot: CISD2_HUMAN, Q8N5K1
    Similarity: Belongs to the CISD protein family. CISD2 subfamily


    CISD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CISD2_HUMAN, Q8N5K1
    Function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the
    endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated
    depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while
    it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its
    function as regulator of autophagy
    Biophysicochemical properties: Redox potential: E is 0 +/- 10 mV for 2Fe-2S at pH 7.5;

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042803protein homodimerization activity IDA19580816
    GO:0046872metal ion binding IEA--
    GO:00515372 iron, 2 sulfur cluster binding IDA19580816
         
    CISD2 for ontologies           About GeneDecksing


    Phenotypes:
         15/20 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cisd2) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism 
     integument  mortality/aging  muscle  nervous system  other 

    CISD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cisd2tm1Tfts for CISD2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CISD2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CISD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CISD2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CISD2 

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CISD2 (see all 43):
    hsa-miR-548j hsa-miR-199a-3p hsa-miR-128 hsa-miR-3167 hsa-miR-3667-5p hsa-miR-208b hsa-miR-208a hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidCISD2 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CISD2 (NM_001008388)
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                         Customized lentivirus expression plasmids for stable overexpression of CISD2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISD2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CISD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for CISD2 (Q8N5K13 ENSP000002739864) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    IKBKEQ141643I2D: score=1 
    BCL2ENSP000003296234STRING: ENSP00000329623
    TMEM33ENSP000002644524STRING: ENSP00000264452
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000422mitochondrion degradation IEA--
    GO:0010259multicellular organismal aging ISS--
    GO:0010506regulation of autophagy IMP--

    CISD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CISD2

    2 HMDB Compounds for CISD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--

    Search CenterWatch for drugs/clinical trials and news about CISD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CISD2 gene: 
    NM_001008388.4  

    Unigene Cluster for CISD2:

    CDGSH iron sulfur domain 2
    Hs.745013  [show with all ESTs]
    Unigene Representative Sequence: NM_001008388
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273986(uc003hwt.4) ENST00000574446 ENST00000503643
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CISD2
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CISD2 (see all 43):
    hsa-miR-548j hsa-miR-199a-3p hsa-miR-128 hsa-miR-3167 hsa-miR-3667-5p hsa-miR-208b hsa-miR-208a hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidCISD2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CISD2
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    GenScript: all cDNA clones in your preferred vector: CISD2 (NM_001008388)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CISD2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CISD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CISD2

    Additional mRNA sequence: 

    AK292134.1 BC020831.1 BC032300.1 BX537971.1 

    13 DOTS entries:

    DT.100799362  DT.100798687  DT.215563  DT.100798685  DT.100798688  DT.100798682  DT.40127037  DT.97779343 
    DT.100798684  DT.121253305  DT.97775151  DT.100798686  DT.95136342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CISD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAAATGCT
    CISD2 Expression
    About this image


    See CISD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CISD2

    SOURCE GeneReport for Unigene cluster: Hs.745013

    UniProtKB/Swiss-Prot: CISD2_HUMAN, Q8N5K1
    Tissue specificity: Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CISD2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cisd21 , 5 CDGSH iron sulfur domain 21, 5 86.17(n)1
    96.3(a)1
      3 (62.55 cM)5
    670061  NM_025902.31  NP_080178.11 
     1354064125 
    chicken
    (Gallus gallus)
    Aves CISD21 CDGSH iron sulfur domain 2 83.83(n)
    95.52(a)
      422714  XM_420668.3  XP_420668.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cisd21 CDGSH iron sulfur domain 2 68.17(n)
    81.2(a)
      393354  NM_200383.1  NP_956677.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14581 CG1458 49.87(n)
    47.29(a)
      43459  NM_143427.3  NP_651684.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.156
    Protein W02B12.15, isoform b
    34(a)
    1 → many
    II(11468552-11469624)


    ENSEMBL Gene Tree for CISD2 (if available)
    TreeFam Gene Tree for CISD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CISD2 gene
    CISD12  
    1 SIMAP similar gene for CISD2 using alignment to 3 protein entries:     CISD2_HUMAN (see all proteins):
    CISD1

    CISD2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CISD2
    PGOHUM00000238741 PGOHUM00000248824 PGOHUM00000246378 PGOHUM00000240772


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 SNPs in CISD2 are shown (see all 287)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs637498881,2
    Cpathogenic1103608724(+) TTTCAC/GAATGG 2 Q E mis10--------
    rs1419013861,2
    --99540393(+) ATATTA/CACCGT 1 -- int10--------
    rs1852136351,2
    --99540427(+) TATGCG/TTTAAT 1 -- int10--------
    rs1899106641,2
    --99540498(+) CCTGTA/GAGCAT 1 -- int10--------
    rs1819485051,2
    --99540780(+) TCTTCC/GTCCTG 1 -- int10--------
    rs1388558421,2
    C--99540819(+) TGCATG/TGCATA 1 -- int10--------
    rs1874099901,2
    --99540849(+) GAACTA/GTAAGT 1 -- int10--------
    rs1123188681,2
    C,F--99541078(+) GACAAA/TGTTCA 1 -- int13Minor allele frequency- T:0.05CSA WA 122
    rs782403141,2
    C,F--99541388(+) CAATAG/CTTAAA 1 -- int11Minor allele frequency- C:0.04EA 120
    rs1915724681,2
    --99541399(+) TAGTAC/TTATTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CISD2 (103790135 - 103813964 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CISD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678594CNV Deletion23128226
    nsv528680CNV Loss19592680
    nsv879683CNV Loss21882294
    nsv461598CNV Loss19166990
    dgv1656e1CNV Complex17122850
    dgv1655e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CISD2

    Locus Specific Mutation Databases (LSDB): CISD2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611507   
    OMIM disorders: 604928  
    UniProtKB/Swiss-Prot: CISD2_HUMAN, Q8N5K1
  • Wolfram syndrome 2 (WFS2) [MIM:604928]: A rare disorder characterized by juvenile-onset insulin-dependent
    diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness,
    dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal
    ulceration. Diabetes insipidus may be absent. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 6 diseases for CISD2:    About MalaCards
    wolfram syndrome 2    wolfram syndrome    optic atrophy    diabetes insipidus
    dementia    diabetes mellitus

    3 diseases from the University of Copenhagen DISEASES database for CISD2:
    Waterhouse-Friderichsen syndrome     Wolfram syndrome     Optic atrophy

    CISD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CISD2

    Export disorders for CISD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CISD2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CISD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2. (PubMed id 17846994)1, 2, 3 Amr S....Shiang R. (2007)
    2. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. (PubMed id 17376863)1, 2, 3 Wiley S.E.... Dixon J.E. (2007)
    3. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. (PubMed id 20010695)1, 2 Chang N.C.... Shore G.C. (2010)
    4. Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. (PubMed id 19580816)1, 2 Conlan A.R.... Paddock M.L. (2009)
    5. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. (PubMed id 17584744)1, 3 Wiley S.E....Dixon J.E. (2007)
    6. A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
    7. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 493856 HGNC: 24212 Ensembl:ENSG00000145354 euGenes: HUgn493856 ECgene: CISD2
    H-InvDB: CISD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CISD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CISD2 gene:
    Search GeneIP for patents involving CISD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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