Aliases for CISD2 Gene
External Ids for CISD2 Gene
Previous Symbols for CISD2 Gene
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
GeneCards Summary for CISD2 Gene
CISD2 (CDGSH Iron Sulfur Domain 2) is a Protein Coding gene. Diseases associated with CISD2 include waterhouse-friderichsen syndrome and wolfram syndrome 2. GO annotations related to this gene include protein homodimerization activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is CISD1.
UniProtKB/Swiss-Prot for CISD2 Gene
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.