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Aliases for CISD1 Gene

Aliases for CISD1 Gene

  • CDGSH Iron Sulfur Domain 1 2 3 5
  • Zinc Finger, CDGSH-Type Domain 1 2 3
  • MitoNEET 3 4
  • C10orf70 3 4
  • ZCD1 3 4
  • CDGSH Iron Sulfur Domain-Containing Protein 1 3
  • Chromosome 10 Open Reading Frame 70 2
  • Zinc Finger CDGSH-Type Domain 1 3
  • MDS029 3

External Ids for CISD1 Gene

Previous HGNC Symbols for CISD1 Gene

  • C10orf70
  • ZCD1

Previous GeneCards Identifiers for CISD1 Gene

  • GC10P059700
  • GC10P060028
  • GC10P054017

Summaries for CISD1 Gene

Entrez Gene Summary for CISD1 Gene

  • This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for CISD1 Gene

CISD1 (CDGSH Iron Sulfur Domain 1) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Adipogenesis. GO annotations related to this gene include 2 iron, 2 sulfur cluster binding. An important paralog of this gene is CISD2.

UniProtKB/Swiss-Prot for CISD1 Gene

  • Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CISD1 Gene

Genomics for CISD1 Gene

Regulatory Elements for CISD1 Gene

Enhancers for CISD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CISD1 on UCSC Golden Path with GeneCards custom track

Promoters for CISD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CISD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CISD1 Gene

58,269,058 bp from pter
58,289,586 bp from pter
20,529 bases
Plus strand

Genomic View for CISD1 Gene

Genes around CISD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CISD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CISD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CISD1 Gene

Proteins for CISD1 Gene

  • Protein details for CISD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CDGSH iron-sulfur domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q1X902

    Protein attributes for CISD1 Gene

    108 amino acids
    Molecular mass:
    12199 Da
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    • Homodimer.
    • Binds pioglitazone, an anti-diabetes drug. Binding increases the stability of the 2Fe-2S cluster.

    Three dimensional structures from OCA and Proteopedia for CISD1 Gene

neXtProt entry for CISD1 Gene

Proteomics data for CISD1 Gene at MOPED

Post-translational modifications for CISD1 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 42, Lys 78, Lys 79, Lys 89, Lys 105, and Lys 106
  • Modification sites at PhosphoSitePlus

Other Protein References for CISD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CISD1 Gene

Domains & Families for CISD1 Gene

Gene Families for CISD1 Gene

Protein Domains for CISD1 Gene

Suggested Antigen Peptide Sequences for CISD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CISD protein family.
  • Belongs to the CISD protein family.
genes like me logo Genes that share domains with CISD1: view

Function for CISD1 Gene

Molecular function for CISD1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Redox potential: E is 0 +/- 10 mV for 2Fe-2S at pH 7.5. {ECO:0000269 PubMed:19580816};
UniProtKB/Swiss-Prot Function:
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions.
UniProtKB/Swiss-Prot Induction:
Expression is down-regulated by glibenclamide and 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-(3-trifluoromethyl)phenyl-4-thiazolidinone (CFTR(inh)172), and up-regulated by cAMP/isoproterenol/IBMX, components that inhibit and stimulate chloride transport activity respectively.

Phenotypes for CISD1 Gene

MGI mutant phenotypes for CISD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CISD1:
genes like me logo Genes that share phenotypes with CISD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CISD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CISD1 Gene

Localization for CISD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CISD1 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein.

Subcellular locations from

Jensen Localization Image for CISD1 Gene COMPARTMENTS Subcellular localization image for CISD1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CISD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CISD1: view

Pathways & Interactions for CISD1 Gene

genes like me logo Genes that share pathways with CISD1: view

Pathways by source for CISD1 Gene

1 Cell Signaling Technology pathway for CISD1 Gene
1 BioSystems pathway for CISD1 Gene

Gene Ontology (GO) - Biological Process for CISD1 Gene


No data available for SIGNOR curated interactions for CISD1 Gene

Drugs & Compounds for CISD1 Gene

(1) Additional Compounds for CISD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with CISD1: view

Transcripts for CISD1 Gene

Unigene Clusters for CISD1 Gene

CDGSH iron sulfur domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CISD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
SP1: - - - - -
SP2: - -
SP4: - - -
SP5: - -

Relevant External Links for CISD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CISD1 Gene

mRNA expression in normal human tissues for CISD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CISD1 Gene

This gene is overexpressed in Nasal epithelium (34.4) and Frontal cortex (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CISD1 Gene

SOURCE GeneReport for Unigene cluster for CISD1 Gene Hs.370102

mRNA Expression by UniProt/SwissProt for CISD1 Gene

Tissue specificity: Expression is reduced in cells derived from cystic fibrosis patients.
genes like me logo Genes that share expression patterns with CISD1: view

Protein tissue co-expression partners for CISD1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CISD1 Gene

Orthologs for CISD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CISD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CISD1 35
  • 92.77 (n)
  • 92.45 (a)
CISD1 36
  • 90 (a)
(Canis familiaris)
Mammalia LOC102154780 35
  • 93.2 (n)
  • 91.26 (a)
CISD1 36
  • 91 (a)
(Mus musculus)
Mammalia Cisd1 35
  • 80.86 (n)
  • 86.11 (a)
Cisd1 16
Cisd1 36
  • 86 (a)
(Pan troglodytes)
Mammalia CISD1 35
  • 100 (n)
  • 100 (a)
CISD1 36
  • 100 (a)
CISD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cisd1 35
  • 80.56 (n)
  • 86.11 (a)
(Monodelphis domestica)
Mammalia CISD1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CISD1 36
  • 78 (a)
(Gallus gallus)
Aves CISD1 35
  • 75.62 (n)
  • 77.78 (a)
CISD1 36
  • 78 (a)
(Anolis carolinensis)
Reptilia CISD1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cisd1 35
  • 72.88 (n)
  • 73.53 (a)
Str.5969 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8356 35
(Danio rerio)
Actinopterygii -- 35
cisd1 35
  • 66.35 (n)
  • 67.62 (a)
cisd1 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1458 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea W02B12.15 35
  • 58.04 (n)
  • 54.12 (a)
W02B12.15 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2896 36
  • 29 (a)
Species with no ortholog for CISD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CISD1 Gene

Gene Tree for CISD1 (if available)
Gene Tree for CISD1 (if available)

Paralogs for CISD1 Gene

Paralogs for CISD1 Gene

(1) SIMAP similar genes for CISD1 Gene using alignment to 1 proteins: Pseudogenes for CISD1 Gene

genes like me logo Genes that share paralogs with CISD1: view

Variants for CISD1 Gene

Sequence variations from dbSNP and Humsavar for CISD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1550773 -- 58,284,681(+) TTCTT(A/T)ATATT intron-variant
rs1815610 -- 58,278,225(+) TACTA(C/T)CACTC intron-variant
rs1867571 -- 58,279,090(+) GTGAT(A/G)CAAGA intron-variant
rs1867572 -- 58,279,180(+) ATTCA(A/C)AAAAC intron-variant
rs1867573 -- 58,283,212(+) AGTGC(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CISD1 Gene

Variant ID Type Subtype PubMed ID
nsv895561 CNV Gain 21882294

Variation tolerance for CISD1 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CISD1 Gene

Disorders for CISD1 Gene

Relevant External Links for CISD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CISD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CISD1 Gene

Publications for CISD1 Gene

  1. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. (PMID: 17584744) Wiley S.E. … Dixon J.E. (J. Biol. Chem. 2007) 2 3 4 67
  2. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. (PMID: 17376863) Wiley S.E. … Dixon J.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3
  3. Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease. (PMID: 25448035) Tamir S. … Nechushtai R. (Biochim. Biophys. Acta 2015) 3
  4. Reduction of mitochondrial protein mitoNEET [2Fe-2S] clusters by human glutathione reductase. (PMID: 25645953) Landry A.P. … Ding H. (Free Radic. Biol. Med. 2015) 3
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for CISD1 Gene

Sources for CISD1 Gene