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CISD1 Gene

protein-coding   GIFtS: 54
GCID: GC10P060028

CDGSH Iron Sulfur Domain 1

(Previous names: chromosome 10 open reading frame 70, zinc finger, CDGSH-type...)
(Previous symbols: C10orf70, ZCD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDGSH Iron Sulfur Domain 11 2     CDGSH Iron-Sulfur Domain-Containing Protein 12
C10orf701 2 3     mitoNEET2
ZCD11 2 3     Zinc Finger CDGSH-Type Domain 12
Zinc Finger, CDGSH-Type Domain 11 2     MitoNEET3
Chromosome 10 Open Reading Frame 701     MITONEET5
CDGSH Iron Sulfur Domain-Containing Protein 12     

External Ids:    HGNC: 308801   Entrez Gene: 558472   Ensembl: ENSG000001228737   OMIM: 6119325   UniProtKB: Q9NZ453   

Export aliases for CISD1 gene to outside databases

Previous GC identifers: GC10P059700 GC10P054017


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CISD1 Gene:
This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active (2Fe-2S)
cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a
role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a
pseudogene of this gene is located on chromosome 2. (provided by RefSeq, Feb 2012)

GeneCards Summary for CISD1 Gene:
CISD1 (CDGSH iron sulfur domain 1) is a protein-coding gene. Diseases associated with CISD1 include wolfram syndrome 2, and wolfram syndrome. GO annotations related to this gene include 2 iron, 2 sulfur cluster binding. An important paralog of this gene is CISD2.

UniProtKB/Swiss-Prot: CISD1_HUMAN, Q9NZ45
Function: Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By
similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CISD1 gene promoter:
         Pbx1a   p53   CUTL1   Tal-1beta   Cdc5   E47   ZIC2/Zic2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCISD1 promoter sequence
   Search Chromatin IP Primers for CISD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CISD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.1   HGNC cytogenetic band: 10q21.3

CISD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CISD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P060028:  view genomic region     (about GC identifiers)

Start:
60,028,818 bp from pter      End:
60,049,346 bp from pter
Size:
20,529 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CISD1_HUMAN, Q9NZ45 (See protein sequence)
Recommended Name: CDGSH iron-sulfur domain-containing protein 1  
Size: 108 amino acids; 12199 Da
Cofactor: Binds 1 2Fe-2S cluster per subunit. The 2Fe-2S cluster is redox-active and pH labile and is
significantly less stable at pH 4.5 as compared with pH 7.0
Subunit: Homodimer
Miscellaneous: Binds pioglitazone, an anti-diabetes drug. Binding increases the stability of the 2Fe-2S cluster
Selected PDB 3D structures from and Proteopedia for CISD1 (see all 10):
2QD0 (3D)        2QH7 (3D)        2R13 (3D)        3EW0 (3D)        3LPQ (3D)        3REE (3D)    
Secondary accessions: Q1X902

Explore the universe of human proteins at neXtProt for CISD1: NX_Q9NZ45

Explore proteomics data for CISD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CISD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060934.1  
    ENSEMBL proteins: 
     ENSP00000363041  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CISD: CDGSH iron sulfur domain containing

    3 InterPro protein domains:
     IPR006622 FeS-contain_CDGSH-typ_subfam
     IPR019610 FeS-contain_mitoNEET_N
     IPR018967 FeS-contain_CDGSH-typ

    Graphical View of Domain Structure for InterPro Entry Q9NZ45

    ProtoNet protein and cluster: Q9NZ45

    UniProtKB/Swiss-Prot: CISD1_HUMAN, Q9NZ45
    Similarity: Belongs to the CISD protein family


    CISD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CISD1_HUMAN, Q9NZ45
    Function: Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By
    similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions
    Biophysicochemical properties: Redox potential: E is 0 +/- 10 mV for 2Fe-2S at pH 7.5;
    Induction: Expression is down-regulated by glibenclamide and
    5-[(4-carboxyphenyl)methylene]-2-thioxo-3-(3-trifluoromethyl)phenyl-4-thiazolidinone (CFTR(inh)172), and
    up-regulated by cAMP/isoproterenol/IBMX, components that inhibit and stimulate chloride transport activity
    respectively

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
    GO:00515372 iron, 2 sulfur cluster binding IEA--
         
    CISD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CISD1:
     Wnt reporter downregulated 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cisd1):
     cellular 

    CISD1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CISD1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CISD1
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    miRNA
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    miRTarBase miRNAs that target CISD1:
    hsa-mir-92a-3p (MIRT049786), hsa-mir-92b-3p (MIRT040663), hsa-mir-128-3p (MIRT045882)

    Block miRNA regulation of human, mouse, rat CISD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CISD1 (see all 30):
    hsa-miR-3164 hsa-miR-3685 hsa-miR-320a hsa-miR-607 hsa-miR-137 hsa-miR-4328 hsa-miR-134 hsa-miR-767-5p
    SwitchGear 3'UTR luciferase reporter plasmidCISD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CISD1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CISD1_HUMAN, Q9NZ45: Mitochondrion outer membrane; Single-pass type III membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular2
    cytosol1
    golgi apparatus1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    CISD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CISD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis


    1 BioSystems Pathway for CISD1
        Adipogenesis



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CISD1
    Interactions:

        Search GeneGlobe Interaction Network for CISD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CISD1 (Q9NZ453 ENSP000003630414) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAB1Q9Y4783, ENSP000002293284I2D: score=1 STRING: ENSP00000229328
    CLN3Q132863I2D: score=1 
    NR4A2P433543I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    AIFM3ENSP000003353694STRING: ENSP00000335369
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043457regulation of cellular respiration IEA--

    CISD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CISD1

    1 HMDB Compound for CISD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CISD1 gene: 
    NM_018464.4  

    Unigene Cluster for CISD1:

    CDGSH iron sulfur domain 1
    Hs.370102  [show with all ESTs]
    Unigene Representative Sequence: NM_018464
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333926(uc001jkc.4 uc001jkd.4) ENST00000464703 ENST00000489785
    ENST00000488388
    miRNA
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    Block miRNA regulation of human, mouse, rat CISD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CISD1 (see all 30):
    hsa-miR-3164 hsa-miR-3685 hsa-miR-320a hsa-miR-607 hsa-miR-137 hsa-miR-4328 hsa-miR-134 hsa-miR-767-5p
    SwitchGear 3'UTR luciferase reporter plasmidCISD1 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CISD1 (NM_018464)
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      QuantiTect SYBR Green Assays in human, mouse, rat CISD1
      QuantiFast Probe-based Assays in human, mouse, rat CISD1

    Additional mRNA sequence: 

    AF220049.1 AJ293401.1 AK312017.1 AY960578.1 BC005962.1 BC007043.1 BC008474.1 BC059168.1 

    14 DOTS entries:

    DT.112682  DT.97796864  DT.428289  DT.100689064  DT.100821885  DT.121291621  DT.70105127  DT.91765478 
    DT.100668541  DT.121210981  DT.75176194  DT.91730084  DT.91765484  DT.95355407 

    Selected AceView cDNA sequences (see all 318):

    CD679497 BX117989 BF590779 BQ022842 AI369851 BX093768 AA890686 AI478344 
    AA431199 AA975374 AI193216 BU180957 BE465879 AI202765 BC007043 AI431919 
    BE502496 AW272263 AW468790 AL121382 AI702470 BF221845 AI016048 CA868538 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CISD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
    SP1:                    -     -           -                 -     -         
    SP2:                    -                 -                                 
    SP3:                                                                        
    SP4:                    -     -           -                                 
    SP5:                          -           -                                 


    ECgene alternative splicing isoforms for CISD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CISD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGATTTGG
    CISD1 Expression
    About this image


    CISD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Kidney (Urinary System)
    CISD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CISD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370102

    UniProtKB/Swiss-Prot: CISD1_HUMAN, Q9NZ45
    Tissue specificity: Expression is reduced in cells derived from cystic fibrosis patients

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CISD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CISD1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cisd11 , 5 CDGSH iron sulfur domain 11, 5 80.86(n)1
    86.11(a)1
      10 (36.88 cM)5
    526371  NM_134007.41  NP_598768.11 
     713304805 
    chicken
    (Gallus gallus)
    Aves CISD11 CDGSH iron sulfur domain 1 75.62(n)
    77.78(a)
      423642  NM_001199529.1  NP_001186458.1 
    lizard
    (Anolis carolinensis)
    Reptilia CISD16
    CDGSH iron sulfur domain 1
    73(a)
    1 ↔ 1
    GL343378.1(121146-123582)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83562 Xenopus laevis transcribed sequence with weak similarity more 81.19(n)    CA973868.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056783.12   -- 79.79(n)   393577  BC056783.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14586
    --
    32(a)
    1 → many
    3R(25047939-25049149)
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.151 W02B12.15 58.04(n)
    54.12(a)
      3565570  NM_001129176.1  NP_001122648.1 


    ENSEMBL Gene Tree for CISD1 (if available)
    TreeFam Gene Tree for CISD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CISD1 gene
    CISD22  
    1 SIMAP similar gene for CISD1 using alignment to 1 protein entry:     CISD1_HUMAN:
    CISD2

    CISD1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CISD1
    PGOHUM00000239422 PGOHUM00000240590 PGOHUM00000235448


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CISD1 (see all 379)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs763103231,2
    C,F--60029805(+) TTATAA/GTTGTT 1 -- int12Minor allele frequency- G:0.11WA 120
    rs1136418951,2
    C,F--60029815(+) TAATAT/CAATAC 1 -- int12Minor allele frequency- C:0.11WA 120
    rs1160111751,2
    C,F--60029867(+) TAAAAC/TGCCAC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs110061011,2
    C,F--60030080(+) CATTTC/TGAAGT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs125721581,2
    H--60030085(+) CGAAGA/TTACTA 1 -- int10--------
    rs1833686041,2
    --60030122(+) AATTAC/TATTAA 1 -- int10--------
    rs1412364631,2
    --60030172(+) TGGTGC/TATTTA 1 -- int10--------
    rs1870815051,2
    --60030185(+) ATAGGA/GTGTGA 1 -- int10--------
    rs733010281,2
    C,F--60030277(+) TGATAT/ATTTTA 1 -- int12Minor allele frequency- A:0.11WA 120
    rs794584101,2
    F--60030412(+) TGAAAC/TGGGTG 1 -- int11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for CISD1 (60028818 - 60049346 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CISD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895561CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CISD1
    DNA2.0 Custom Variant and Variant Library Synthesis for CISD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611932    OMIM disorders: --

    6 diseases for CISD1:    
    About MalaCards
    wolfram syndrome 2    wolfram syndrome    cystic fibrosis    inflammatory bowel disease
    alzheimer's disease    cerebritis


    CISD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CISD1
    Human Genome Epidemiology (HuGE) Navigator: CISD1 (2 documents)

    Export disorders for CISD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CISD1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CISD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. (PubMed id 17584744)1, 2, 3 Wiley S.E.... Dixon J.E. (J. Biol. Chem. 2007)
    2. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. (PubMed id 17376863)1, 2, 3 Wiley S.E.... Dixon J.E. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. CISD1 codifies a mitochondrial protein upregulated by the CFTR channel. (PubMed id 18047834)1, 2 Taminelli G.L.... Santa-Coloma T.A. (Biochem. Biophys. Res. Commun. 2008)
    5. Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins. (PubMed id 17766439)1, 2 Lin J.... Wang J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    6. Crystallographic studies of human MitoNEET. (PubMed id 17905743)1, 2 Hou X.... Gong W. (J. Biol. Chem. 2007)
    7. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. (PubMed id 17766440)1, 2 Paddock M.L....Jennings P.A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Allosteric control in a metalloprotein dramatically alters function. (PubMed id 23271805)1 Baxter E.L....Jennings P.A. (Proc. Natl. Acad. Sci. U.S.A. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55847 HGNC: 30880 AceView: C10orf70 Ensembl:ENSG00000122873 euGenes: HUgn55847
    ECgene: CISD1 H-InvDB: CISD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CISD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CISD1 gene:
    Search GeneIP for patents involving CISD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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