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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CIRBP Gene

protein-coding   GIFtS: 54
GCID: GC19P001269

cold inducible RNA binding protein

(Previous name: cold inducible RNA-binding protein )
 Explore 7 diseases affiliated with
CIRBP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CIRBP    

Aliases
for CIRBP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cold Inducible RNA Binding Protein1 2     A18 HnRNP2 3
CIRP1 2 3     Cold-Inducible RNA-Binding Protein2
Cold Inducible RNA-Binding Protein1 2     Glycine-Rich RNA Binding Protein2
Glycine-Rich RNA-Binding Protein CIRP2 3     A18HNRNP3

External Ids:    HGNC: 19821   Entrez Gene: 11532   Ensembl: ENSG000000996227   OMIM: 6026495   UniProtKB: Q140113   

Export aliases for CIRBP gene to outside databases

Previous GC identifers: GC19P001327 GC19P001209 GC19P001220 GC19P001044


Summaries
for CIRBP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011
Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by
stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an
essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions
(3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes
assembly of stress granules (SGs), when overexpressed

Gene Wiki entry for CIRBP


Genomic Views
for CIRBP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CIRBP gene promoter:
         STAT5B   Elk-1   p53   AP-1   Chx10   Nkx2-5   Pax-4a   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CIRBP promoter sequence
   Search SABiosciences Chromatin IP Primers for CIRBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIRBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CIRBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIRBP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001269:  view genomic region     (about GC identifiers)

Start:
 1,259,384 bp from pter      End:
 1,274,879 bp from pter
Size:
 15,496 bases      Orientation:
 plus strand

Proteins
for CIRBP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011 (See protein sequence)
Recommended Name: Cold-inducible RNA-binding protein  
Size: 172 amino acids; 18648 Da
Subunit: Interacts with EIF4G1. Associates with ribosomes
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after
exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic
stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins
(By similarity)
1 PDB 3D structure from and Proteopedia for CIRBP:
1X5S (3D)    

Explore the universe of human proteins at neXtProt for CIRBP: NX_Q14011

Post-translational modifications:

  • Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By
    • similarity)1
  • Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR
    • transcript upon exposure to UV radiation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14011

    • CIRBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001271.1  
    ENSEMBL proteins: 
     ENSP00000468788   ENSP00000465338   ENSP00000468016   ENSP00000468224   ENSP00000467138  
     ENSP00000466207   ENSP00000467028   ENSP00000467734   ENSP00000466712   ENSP00000467449  
     ENSP00000466897   ENSP00000465558   ENSP00000468229   ENSP00000412831   ENSP00000465779  
     ENSP00000465334   ENSP00000467307   ENSP00000465114   ENSP00000467791   ENSP00000465077  
     ENSP00000322887   ENSP00000467876   ENSP00000464906   ENSP00000466216   ENSP00000464830  
     ENSP00000466025   ENSP00000467848   ENSP00000468097   ENSP00000467948   ENSP00000464728  
     ENSP00000466238   ENSP00000466110   ENSP00000468645   ENSP00000466131   ENSP00000407512  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CIRBP
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    Novus Biologicals CIRBP Proteins
    Novus Biologicals CIRBP Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CIRBP
    Uscn Proteins for CIRBP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm ISS--
    GO:0010494cytoplasmic stress granule ISS--


    CIRBP for ontologies           About GeneDecksing



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    Uscn Antibodies for CIRBP
    ThermoFisher Antibody for CIRBP

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    Uscn ELISAs and CLIAs for CIRBP

    Protein Domains /
    Families
    for CIRBP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CIRBP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q14011

    ProtoNet protein and cluster: Q14011

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011
    Domain: Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN
    3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary
    for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for
    translational repression (By similarity)
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for CIRBP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011
    Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by
    stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an
    essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions
    (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes
    assembly of stress granules (SGs), when overexpressed
    Induction: By cold stress in response to DNA damage induced by UV irradiation or UV mimetic agents. Up-regulated by
    hypoxia

         Genatlas biochemistry entry for CIRBP:
    cold inducible RNA binding-protein,18kDa,ubiquitously expressed,mouse Cirp homolog

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CIRBP (see all 9):
    hsa-miR-526b hsa-miR-548b-3p hsa-miR-3155 hsa-miR-484 hsa-miR-338-5p hsa-miR-3202 hsa-miR-145 hsa-miR-3155b
    SwitchGear 3'UTR luciferase reporter plasmid: CIRBP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CIRBP (see all 7)
    OriGene shRNA RFP: CIRBP
    OriGene siRNA: CIRBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIRBP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CIRBP

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIRBP 

    Cell Line
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    Search LifeMap BioReagents cell lines for CIRBP

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003730mRNA 3'-UTR binding IDA16513844
    GO:0005515protein binding IPI16513844
    GO:0030371translation repressor activity ISS--


    CIRBP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CIRBP:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Cirbptm1Jfuji for CIRBP
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cirbp):
     cellular  reproductive system 

    CIRBP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CIRBP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIRBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/33 Interacting proteins for CIRBP (Q140112, 3 ENSP000003228874) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2857675 I2D: score=3 STRING: ENSP00000244769
    HABP4Q5JVS02, 3, ENSP000003643984MINT-8194629 I2D: score=1 STRING: ENSP00000364398
    SF3A2Q154282, 3, ENSP000002214944MINT-5206304 I2D: score=1 STRING: ENSP00000221494
    HNRNPKP619782, 3, ENSP000003654394MINT-8338674 I2D: score=1 STRING: ENSP00000365439
    PSPHP783303, ENSP000002756054I2D: score=1 STRING: ENSP00000275605
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009409response to cold TAS9151692
    GO:0009411response to UV IDA11574538
    GO:0017148negative regulation of translation ISS--
    GO:0034063stress granule assembly ISS--
    GO:0045727positive regulation of translation IDA11574538


    CIRBP for ontologies           About GeneDecksing



    Drugs & Compounds
    for CIRBP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CIRBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CIRBP
    3 Novoseek chemical compound relationships for CIRBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cycloheximide 35.7 1 16569452 (1)
    pd 98,059 34.5 1 16569452 (1)
    vegf 10.2 2 15075239 (2)

    Search CenterWatch for drugs/clinical trials and news about CIRBP 

    Transcripts
    for CIRBP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CIRBP gene: 
    NM_001280.2  

    Unigene Cluster for CIRBP:

    Cold inducible RNA binding protein
    Hs.618145  [show with all ESTs]
    Unigene Representative Sequence: AK095781
    18/46 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 46):
    ENST00000588030 ENST00000588411 ENST00000592467 ENST00000591622 ENST00000592051
    ENST00000589161 ENST00000589660 ENST00000589266 ENST00000588090 ENST00000592815
    ENST00000591935 ENST00000586548 ENST00000585913 ENST00000593128 ENST00000589710
    ENST00000588230 ENST00000591097 ENST00000590704

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CIRBP
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIRBP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CIRBP (see all 9):
    hsa-miR-526b hsa-miR-548b-3p hsa-miR-3155 hsa-miR-484 hsa-miR-338-5p hsa-miR-3202 hsa-miR-145 hsa-miR-3155b
    SwitchGear 3'UTR luciferase reporter plasmid: CIRBP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CIRBP (see all 7)
    OriGene shRNA RFP: CIRBP
    OriGene siRNA: CIRBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIRBP
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CIRBP
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    GenScript: all cDNA clones in your preferred vector: CIRBP (NM_001280)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIRBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIRBP 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIRBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIRBP

    Additional cDNA sequence: 

    AB451225.1 AB451348.1 AF021336.1 AK094781.1 AK095781.1 AK128423.1 AK304185.1 AK304470.1 
    AK311601.1 AL133636.1 BC000403.2 BC000901.1 BT007210.1 D78134.1 NR_023312.1 NR_023313.1 

    24/57 DOTS entries (see all 57):

    DT.95302005  DT.95253187  DT.40133472  DT.92457557  DT.95340966  DT.100680101  DT.100059852  DT.100680102 
    DT.100059849  DT.97861836  DT.95082497  DT.92457544  DT.91804941  DT.100680105  DT.121482187  DT.121482274 
    DT.92457535  DT.95327061  DT.97861835  DT.100680093  DT.121482397  DT.95117167  DT.101955651  DT.121482278 

    24/1007 AceView cDNA sequences (see all 1007):

    AU104934 BC000403 AU099260 CD675364 CR613900 AA062736 BG896976 CN485113 
    CR618584 BQ445896 BU784454 BM918004 AA335557 AU104932 BE797363 BQ709317 
    CA942903 AW664148 AI590129 BM712190 AI862853 BF725197 BQ933957 CR601213 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CIRBP (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
    SP1:        -     -     -                                   -     -     -     -     -     -               
    SP2:                    -                                   -     -                                       
    SP3:                    -                                                                                 
    SP4:                                                        -     -                                       
    SP5:                                                        -     -     -     -     -                     


    ECgene alternative splicing isoforms for CIRBP

    Expression
    for CIRBP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CIRBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CIRBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CIRBP

    SOURCE GeneReport for Unigene cluster: Hs.618145

    UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for CIRBP
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIRBP

    Orthologs
    for CIRBP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CIRBP gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cirbp1 , 5 cold inducible RNA binding protein1, 5 86.63(n)1
    95.35(a)1    		   10 (39.72 cM)5
    126961  NM_007705.21  NP_031731.11 
     801659855 
    chicken
    (Gallus gallus)    		 Aves CIRBP1 cold inducible RNA binding protein 82.53(n)
    95.78(a)    		   425789  NM_001031347.1  NP_001026518.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CIRBP6
    		 --
    		 92(a)
    		 1 ↔ 1
    		 GL344335.1(55204-58794)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cirbp-prov2 cold inducible RNA-binding protein 81.81(n)    BC041204.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb74g052 Danio rerio mRNA similar to cold inducible RNA binding more 78.04(n)    BC048027.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea R09B3.26
    R09B3.36
    (see all 4)    		 Protein R09B3.3
    (see all 4)    		 42(a)
    39(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 I(11909347-11910095)
    I(11910319-11911012)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CCR21 glycine-rich RNA-binding protein 7 51.42(n)
    47.71(a)    		   816705  NM_127738.4  NP_179760.1 
    rice
    (Oryza sativa)    		 Liliopsida Os12g06320001 hypothetical protein 54.14(n)
    50.35(a)    		   4352868  NM_001073876.1  NP_001067344.1 


    ENSEMBL Gene Tree for CIRBP (if available)
    TreeFam Gene Tree for CIRBP (if available) 

    Paralogs
    for CIRBP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CIRBP gene
    RBMY1E2  RBMY1J2  RBMY1F2  RBMXL22  RBMXL32  TRA2B2  RBMY1B2  RBMXL12  
    RBMY1A12  RBM32  TRA2A2  RBMX2  RBMY1D2  
    18/52 SIMAP similar genes for CIRBP using alignment to 18 protein entries:     CIRBP_HUMAN (see all proteins) (see all similar genes):
    BOLL    RBM3    RBMY1A1    TIAL1    RBM    RBMX
    MSI2    ZCRB1    HNRNPA1    RBM23    RBM42    EIF3G
    SRSF2    HNRNPA3    DAZAP1    HNRNPD    ELAVL2    HNRPA3

    CIRBP for paralogs           About GeneDecksing



    Genomic Variants
    for CIRBP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/140 NCBI SNPs in CIRBP are shown (see all 140)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1379820261,2
    		--1267437(+) ACCCGC/TTCGTA 4 -- int1 us2k10--------
    rs1820230481,2
    		--1267496(+) GAACAC/TGGCGC 4 -- nc-transcript-variantus2k10--------
    rs1427037101,2
    		--1267656(+) GAACGC/TCCACC 4 -- nc-transcript-variantus2k10--------
    rs1505883221,2
    		--1267733(+) GCTGGG/TCATGT 4 -- nc-transcript-variantus2k10--------
    rs1178232311,2
    		--1268070(+) GAGTGG/AGGCCG 4 -- nc-transcript-variantus2k11Minor allele frequency- A:0.01EA 120
    rs1848146561,2
    		--1268103(+) AAAGCA/GGGGGT 4 -- us2k1 nc-transcript-variant0--------
    rs129758751,2
    		C,F,H,--1268178(+) AGAGAA/GGCAGG 4 -- us2k1 nc-transcript-variant25Minor allele frequency- G:0.22NS EA NA WA CSA 2355
    rs1383996451,2
    		--1268313(+) GTGAGA/GGTCCT 4 -- nc-transcript-variantus2k10--------
    rs729795391,2
    		C,F,--1268398(+) TGGAAG/AGAGAG 4 -- int1 us2k12Minor allele frequency- A:0.07NA EA 240
    rs1181779481,2
    		--1268525(+) GTGGGG/AACTCG 4 -- us2k1 int11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for CIRBP (1259384 - 1274879 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CIRBP
         5 CNVs: 30057 30058 4066 29684 30885

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CIRBP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CIRBP for disorders           About GeneDecksing

    OMIM gene information: 602649    OMIM disorders: --

    7 diseases for CIRBP:    About MalaCards
    cryptorchidism    anoxia    endometrial carcinoma    breast cancer
    ataxia    hypoxia    carcinoma

    1 disease from the University of Copenhagen DISEASES database for CIRBP:
    Cryptorchidism

    3 Novoseek disease relationships for CIRBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cryptorchidism 44.2 2 9422546 (1), 10793079 (1)
    shock 43.5 14 17967451 (2), 11095679 (1), 10943555 (1), 19277990 (1) (see all 5)
    cancer 0 2 19158277 (1)


    Export disorders for CIRBP gene to outside databases

    Publications
    for CIRBP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CIRBP gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with CIRBP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human CIRP (cold-inducible RNA- binding protein) cDNA and chromosomal assignment of the gene. (PubMed id 9434172)1, 2, 3, 9 Nishiyama H.... Fujita J. (1997)
    2. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. (PubMed id 15075239)1, 2, 9 Wellmann S.... Seeger K. (2004)
    3. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. (PubMed id 11574538)1, 2, 9 Yang C. and Carrier F. (2001)
    4. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18. (PubMed id 16513844)1, 2 Yang R.... Carrier F. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    7. Identification of several human homologs of hamster DNA damage- inducible transcripts. Cloning and characterization of a novel UV- inducible cDNA that codes for a putative RNA-binding protein. (PubMed id 9334257)1, 2 Sheikh M.S.... Fornace A.J. Jr. (1997)
    8. A glycine-rich RNA-binding protein mediating cold-ind ucible suppression of mammalian cell growth. (PubMed id 9151692)1, 3 Nishiyama H....Fujita J. (1997)
    9. Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. (PubMed id 9422546)1, 9 Nishiyama H....Fujita J. (1998)
    10. Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma. (PubMed id 12819390)1, 9 Hamid A.A....Fujii S. (2003)

    External Searches for CIRBP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing CIRBP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1153 HGNC: 1982 AceView: CIRBP Ensembl:ENSG00000099622 euGenes: HUgn1153
    ECgene: CIRBP H-InvDB: CIRBP

    Other Databases showing CIRBP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CIRBP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CIRBP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CIRBP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CIRBP gene:
    Search GeneIP for patents involving CIRBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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