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Aliases for CIRBP Gene

Aliases for CIRBP Gene

  • Cold Inducible RNA Binding Protein 2 3
  • Cold-Inducible RNA-Binding Protein 2 3
  • Cold Inducible RNA-Binding Protein 2 3
  • Glycine-Rich RNA Binding Protein 2 3
  • A18 HnRNP 3 4
  • CIRP 3 4
  • Glycine-Rich RNA-Binding Protein CIRP 4
  • A18HNRNP 4

External Ids for CIRBP Gene

Previous GeneCards Identifiers for CIRBP Gene

  • GC19P001327
  • GC19P001209
  • GC19P001220
  • GC19P001044

Summaries for CIRBP Gene

GeneCards Summary for CIRBP Gene

CIRBP (Cold Inducible RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and translation repressor activity. An important paralog of this gene is RBMXL1.

UniProtKB/Swiss-Prot for CIRBP Gene

  • Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3-untranslated regions (3-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

Gene Wiki entry for CIRBP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIRBP Gene

Genomics for CIRBP Gene

Regulatory Elements for CIRBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CIRBP Gene

Start:
1,259,384 bp from pter
End:
1,274,880 bp from pter
Size:
15,497 bases
Orientation:
Plus strand

Genomic View for CIRBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIRBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIRBP Gene

Proteins for CIRBP Gene

  • Protein details for CIRBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14011-CIRBP_HUMAN
    Recommended name:
    Cold-inducible RNA-binding protein
    Protein Accession:
    Q14011
    Secondary Accessions:
    • B3KT17
    • B4E2X2

    Protein attributes for CIRBP Gene

    Size:
    172 amino acids
    Molecular mass:
    18648 Da
    Quaternary structure:
    • Interacts with EIF4G1. Associates with ribosomes.

    Three dimensional structures from OCA and Proteopedia for CIRBP Gene

    Alternative splice isoforms for CIRBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIRBP Gene

Proteomics data for CIRBP Gene at MOPED

Post-translational modifications for CIRBP Gene

  • Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
  • Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3-UTR transcript upon exposure to UV radiation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CIRBP (CIRBP)

No data available for DME Specific Peptides for CIRBP Gene

Domains for CIRBP Gene

Gene Families for CIRBP Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for CIRBP Gene

Graphical View of Domain Structure for InterPro Entry

Q14011

UniProtKB/Swiss-Prot:

CIRBP_HUMAN :
  • Q14011
Domain:
  • Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity).
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with CIRBP: view

Function for CIRBP Gene

Molecular function for CIRBP Gene

GENATLAS Biochemistry:
cold inducible RNA binding-protein,18kDa,ubiquitously expressed,mouse Cirp homolog
UniProtKB/Swiss-Prot Function:
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3-untranslated regions (3-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
UniProtKB/Swiss-Prot Induction:
By cold stress in response to DNA damage induced by UV irradiation or UV mimetic agents. Up-regulated by hypoxia.

Gene Ontology (GO) - Molecular Function for CIRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003730 mRNA 3-UTR binding IDA 11574538
GO:0005515 protein binding IPI 16189514
GO:0030371 translation repressor activity ISS --
genes like me logo Genes that share ontologies with CIRBP: view

Phenotypes for CIRBP Gene

MGI mutant phenotypes for CIRBP:
inferred from 1 alleles
GenomeRNAi human phenotypes for CIRBP:
genes like me logo Genes that share phenotypes with CIRBP: view

Animal Models for CIRBP Gene

MGI Knock Outs for CIRBP:

Animal Model Products

CRISPR Products

miRNA for CIRBP Gene

miRTarBase miRNAs that target CIRBP

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIRBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CIRBP Gene

Localization for CIRBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIRBP Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIRBP Gene COMPARTMENTS Subcellular localization image for CIRBP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CIRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm ISS --
GO:0010494 cytoplasmic stress granule ISS --
genes like me logo Genes that share ontologies with CIRBP: view

Pathways for CIRBP Gene

SuperPathways for CIRBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009409 response to cold TAS 9151692
GO:0009411 response to UV IDA 11574538
GO:0017148 negative regulation of translation ISS --
GO:0034063 stress granule assembly ISS --
GO:0045727 positive regulation of translation IDA 11574538
genes like me logo Genes that share ontologies with CIRBP: view

No data available for Pathways by source for CIRBP Gene

Compounds for CIRBP Gene

(3) Novoseek inferred chemical compound relationships for CIRBP Gene

Compound -log(P) Hits PubMed IDs
cycloheximide 35.7 1
pd 98,059 34.5 1
vegf 10.2 2
genes like me logo Genes that share compounds with CIRBP: view

Transcripts for CIRBP Gene

Unigene Clusters for CIRBP Gene

Cold inducible RNA binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIRBP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIRBP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
SP1: - - - - - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: -

Relevant External Links for CIRBP Gene

GeneLoc Exon Structure for
CIRBP
ECgene alternative splicing isoforms for
CIRBP

Expression for CIRBP Gene

mRNA expression in normal human tissues for CIRBP Gene

Protein differential expression in normal tissues for CIRBP Gene

This gene is overexpressed in Nasal epithelium (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIRBP Gene

SOURCE GeneReport for Unigene cluster for CIRBP Gene Hs.618145

mRNA Expression by UniProt/SwissProt for CIRBP Gene

Q14011-CIRBP_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CIRBP: view

Expression partners for CIRBP Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CIRBP Gene

Orthologs for CIRBP Gene

This gene was present in the common ancestor of animals.

Orthologs for CIRBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CIRBP 35
  • 90.56 (n)
  • 98.8 (a)
CIRBP 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIRBP 35
  • 91.09 (n)
  • 98.26 (a)
CIRBP 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cirbp 35
  • 86.63 (n)
  • 95.35 (a)
Cirbp 16
Cirbp 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CIRBP 35
  • 83.18 (n)
  • 81.08 (a)
CIRBP 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cirbp 35
  • 85.08 (n)
  • 94.77 (a)
oppossum
(Monodelphis domestica)
Mammalia CIRBP 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CIRBP 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CIRBP 35
  • 82.44 (n)
  • 95.21 (a)
CIRBP 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CIRBP 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cirbp 35
  • 71.17 (n)
  • 77.3 (a)
African clawed frog
(Xenopus laevis)
Amphibia cirbp-prov 35
zebrafish
(Danio rerio)
Actinopterygii cirbpa 35
  • 61.01 (n)
  • 62.42 (a)
wufb74g05 35
cirbp 36
  • 54 (a)
OneToMany
CIRBP (2 of 2) 36
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3932 35
fruit fly
(Drosophila melanogaster)
Insecta tra2 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 36
  • 19 (a)
OneToMany
Species with no ortholog for CIRBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIRBP Gene

ENSEMBL:
Gene Tree for CIRBP (if available)
TreeFam:
Gene Tree for CIRBP (if available)

Paralogs for CIRBP Gene

Paralogs for CIRBP Gene

genes like me logo Genes that share paralogs with CIRBP: view

Variants for CIRBP Gene

Sequence variations from dbSNP and Humsavar for CIRBP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12412 -- 1,272,895(+) TTCCA(A/C)CTCCG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs13369 -- 1,272,838(+) AGATC(A/G)AACGG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1803281 -- 1,272,528(+) AGTAA(A/G)TGCAC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1803282 -- 1,273,080(+) GCATA(C/T)TCCAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs11555034 -- 1,272,447(+) AAAAA(A/C)CCTTC utr-variant-3-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CIRBP Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
dgv3592n71 CNV Loss 21882294
nsv828368 CNV Gain 20364138
dgv3594n71 CNV Loss 21882294
nsv910471 CNV Loss 21882294
dgv3595n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
nsv828371 CNV Loss 20364138
nsv910475 CNV Loss 21882294
nsv910476 CNV Loss 21882294

Relevant External Links for CIRBP Gene

HapMap Linkage Disequilibrium report
CIRBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIRBP Gene

Disorders for CIRBP Gene

(1) University of Copenhagen DISEASES for CIRBP Gene

(3) Novoseek inferred disease relationships for CIRBP Gene

Disease -log(P) Hits PubMed IDs
cryptorchidism 44.2 2
shock 43.5 6
cancer 0 1
genes like me logo Genes that share disorders with CIRBP: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for CIRBP Gene

Publications for CIRBP Gene

  1. Cloning and characterization of human CIRP (cold-inducible RNA- binding protein) cDNA and chromosomal assignment of the gene. (PMID: 9434172) Nishiyama H. … Fujita J. (Gene 1997) 2 3 4 23
  2. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. (PMID: 11574538) Yang C. … Carrier F. (J. Biol. Chem. 2001) 3 4 23
  3. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. (PMID: 15075239) Wellmann S. … Seeger K. (J. Cell Sci. 2004) 3 4 23
  4. Post-transcriptional regulation of thioredoxin by the stress inducible heterogeneous ribonucleoprotein A18. (PMID: 16513844) Yang R. … Carrier F. (Nucleic Acids Res. 2006) 3 4
  5. Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation. (PMID: 19158277) Artero-Castro A. … Lleonart M.E. (Mol. Cell. Biol. 2009) 3 23

Products for CIRBP Gene

  • Addgene plasmids for CIRBP

Sources for CIRBP Gene

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