Aliases for CIRBP Gene
External Ids for CIRBP Gene
Previous GeneCards Identifiers for CIRBP Gene
GeneCards Summary for CIRBP Gene
CIRBP (Cold Inducible RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and translation repressor activity. An important paralog of this gene is RBMXL1.
UniProtKB/Swiss-Prot for CIRBP Gene
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3-untranslated regions (3-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.