Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CIRBP Gene

protein-coding   GIFtS: 55
GCID: GC19P001269

Cold Inducible RNA Binding Protein

(Previous name: cold inducible RNA-binding protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cold Inducible RNA Binding Protein1 2     Glycine-Rich RNA-Binding Protein CIRP2 3
Cold Inducible RNA-Binding Protein1 2     CIRP2 3
Cold-Inducible RNA-Binding Protein1 2     A18 HnRNP2 3
Glycine-Rich RNA Binding Protein1 2     A18HNRNP3

External Ids:    HGNC: 19821   Entrez Gene: 11532   Ensembl: ENSG000000996227   OMIM: 6026495   UniProtKB: Q140113   

Export aliases for CIRBP gene to outside databases

Previous GC identifers: GC19P001327 GC19P001209 GC19P001220 GC19P001044


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CIRBP Gene:
CIRBP (cold inducible RNA binding protein) is a protein-coding gene. Diseases associated with CIRBP include cryptorchidism, and anoxia. GO annotations related to this gene include translation repressor activity and nucleotide binding. An important paralog of this gene is RBMY1J.

UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011
Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by
stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an
essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated
regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By
similarity). Promotes assembly of stress granules (SGs), when overexpressed

Gene Wiki entry for CIRBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CIRBP gene promoter:
         STAT5B   Elk-1   p53   AP-1   Chx10   Nkx2-5   Pax-4a   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCIRBP promoter sequence
   Search Chromatin IP Primers for CIRBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIRBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CIRBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIRBP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001269:  view genomic region     (about GC identifiers)

Start:
1,259,384 bp from pter      End:
1,274,879 bp from pter
Size:
15,496 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011 (See protein sequence)
Recommended Name: Cold-inducible RNA-binding protein  
Size: 172 amino acids; 18648 Da
Subunit: Interacts with EIF4G1. Associates with ribosomes
1 PDB 3D structure from and Proteopedia for CIRBP:
1X5S (3D)    

Explore the universe of human proteins at neXtProt for CIRBP: NX_Q14011

Explore proteomics data for CIRBP at MOPED

Post-translational modifications: 

  • Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By
    similarity)1
  • Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR
    transcript upon exposure to UV radiation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CIRBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001271.1  
    ENSEMBL proteins: 
     ENSP00000468788   ENSP00000465338   ENSP00000468016   ENSP00000468224   ENSP00000467138  
     ENSP00000466207   ENSP00000467028   ENSP00000467734   ENSP00000466712   ENSP00000467449  
     ENSP00000466897   ENSP00000465558   ENSP00000468229   ENSP00000412831   ENSP00000465779  
     ENSP00000465334   ENSP00000467307   ENSP00000465114   ENSP00000467791   ENSP00000465077  
     ENSP00000322887   ENSP00000467876   ENSP00000464906   ENSP00000466216   ENSP00000464830  
     ENSP00000466025   ENSP00000467848   ENSP00000468097   ENSP00000467948   ENSP00000464728  
     ENSP00000466238   ENSP00000466110   ENSP00000468645   ENSP00000466131   ENSP00000407512  

    CIRBP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CIRBP
    OriGene Protein Over-expression Lysate for CIRBP
    OriGene MassSpec for CIRBP
    OriGene Custom Protein Services for CIRBP
    GenScript Custom Purified and Recombinant Proteins Services for CIRBP
    Novus Biologicals CIRBP Proteins
    Novus Biologicals CIRBP Lysates
    Sino Biological Recombinant Protein for CIRBP
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CIRBP
    Cloud-Clone Corp. Proteins for CIRBP

    CIRBP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CIRBP
    Novus Biologicals CIRBP Antibodies
    Abcam antibodies for CIRBP
    Cloud-Clone Corp. Antibodies for CIRBP
    ThermoFisher Antibody for CIRBP
    LSBio Antibodies in human, mouse, rat for CIRBP

    CIRBP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CIRBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CIRBP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CIRBP
    Cloud-Clone Corp. CLIAs for CIRBP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q14011

    ProtoNet protein and cluster: Q14011

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011
    Domain: Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN
    3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are
    necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is
    necessary for translational repression (By similarity)
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    CIRBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIRBP_HUMAN, Q14011
    Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by
    stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an
    essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated
    regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By
    similarity). Promotes assembly of stress granules (SGs), when overexpressed
    Induction: By cold stress in response to DNA damage induced by UV irradiation or UV mimetic agents. Up-regulated
    by hypoxia

         Genatlas biochemistry entry for CIRBP:
    cold inducible RNA binding-protein,18kDa,ubiquitously expressed,mouse Cirp homolog

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003730mRNA 3'-UTR binding IDA11574538
    GO:0005515protein binding IPI16513844
    GO:0030371translation repressor activity ISS--
         
    CIRBP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CIRBP:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cirbp):
     cellular  reproductive system 

    CIRBP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cirbptm1Jfuji for CIRBP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIRBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CIRBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIRBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIRBP

    miRNA
    Products:
        
    miRTarBase miRNAs that target CIRBP:
    hsa-mir-30a-5p (MIRT028434), hsa-mir-24-3p (MIRT030423)

    Block miRNA regulation of human, mouse, rat CIRBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CIRBP (see all 9):
    hsa-miR-526b hsa-miR-548b-3p hsa-miR-3155 hsa-miR-484 hsa-miR-338-5p hsa-miR-3202 hsa-miR-145 hsa-miR-3155b
    SwitchGear 3'UTR luciferase reporter plasmidCIRBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CIRBP
    Predesigned siRNA for gene silencing in human, mouse, rat CIRBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CIRBP

    Clone
    Products:
         
    OriGene clones in human, mouse for CIRBP (see all 6)
    OriGene ORF clones in mouse, rat for CIRBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIRBP (NM_001280)
    Sino Biological Human cDNA Clone for CIRBP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIRBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIRBP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CIRBP
    Browse ESI BIO Cell Lines and PureStem Progenitors for CIRBP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIRBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CIRBP_HUMAN, Q14011: Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after
    exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various
    cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence
    of TIAR proteins (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm ISS--
    GO:0010494cytoplasmic stress granule ISS--

    CIRBP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CIRBP
    Interactions:

        Search GeneGlobe Interaction Network for CIRBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CIRBP (Q140112, 3 ENSP000003228874) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2857675 I2D: score=3 STRING: ENSP00000244769
    HABP4Q5JVS02, 3, ENSP000003643984MINT-8194629 I2D: score=1 STRING: ENSP00000364398
    SF3A2Q154282, 3, ENSP000002214944MINT-5206304 I2D: score=1 STRING: ENSP00000221494
    HNRNPKP619782, 3, ENSP000003654394MINT-8338674 I2D: score=1 STRING: ENSP00000365439
    PSPHP783303, ENSP000002756054I2D: score=1 STRING: ENSP00000275605
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009409response to cold IEA--
    GO:0009411response to UV IDA11574538
    GO:0017148negative regulation of translation ----
    GO:0034063stress granule assembly ISS--
    GO:0045727positive regulation of translation IDA11574538

    CIRBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CIRBP

    3 Novoseek inferred chemical compound relationships for CIRBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cycloheximide 35.7 1 16569452 (1)
    pd 98,059 34.5 1 16569452 (1)
    vegf 10.2 2 15075239 (2)



    CIRBP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CIRBP gene: 
    NM_001280.2  

    Unigene Cluster for CIRBP:

    Cold inducible RNA binding protein
    Hs.618145  [show with all ESTs]
    Unigene Representative Sequence: AK095781
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 46):
    ENST00000588030 ENST00000588411 ENST00000592467 ENST00000591622 ENST00000592051
    ENST00000589161 ENST00000589660 ENST00000589266 ENST00000588090 ENST00000592815
    ENST00000591935 ENST00000586548 ENST00000585913 ENST00000593128 ENST00000589710
    ENST00000588230 ENST00000591097 ENST00000590704
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CIRBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CIRBP (see all 9):
    hsa-miR-526b hsa-miR-548b-3p hsa-miR-3155 hsa-miR-484 hsa-miR-338-5p hsa-miR-3202 hsa-miR-145 hsa-miR-3155b
    SwitchGear 3'UTR luciferase reporter plasmidCIRBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CIRBP
    Predesigned siRNA for gene silencing in human, mouse, rat CIRBP
    Clone
    Products:
         
    OriGene clones in human, mouse for CIRBP (see all 6)
    OriGene ORF clones in mouse, rat for CIRBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIRBP (NM_001280)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIRBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIRBP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CIRBP
    OriGene qSTAR qPCR primer pairs in human, mouse for CIRBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CIRBP
      QuantiTect SYBR Green Assays in human, mouse, rat CIRBP
      QuantiFast Probe-based Assays in human, mouse, rat CIRBP

    Additional mRNA sequence: 

    AB451225.1 AB451348.1 AF021336.1 AK094781.1 AK095781.1 AK128423.1 AK304185.1 AK304470.1 
    AK311601.1 AL133636.1 BC000403.2 BC000901.1 BT007210.1 D78134.1 NR_023312.1 NR_023313.1 

    Selected DOTS entries (see all 57):

    DT.95302005  DT.95253187  DT.40133472  DT.92457557  DT.95340966  DT.100680101  DT.100059852  DT.100680102 
    DT.100059849  DT.97861836  DT.95082497  DT.92457544  DT.91804941  DT.100680105  DT.121482187  DT.121482274 
    DT.92457535  DT.95327061  DT.97861835  DT.100680093  DT.121482397  DT.95117167  DT.101955651  DT.121482278 

    Selected AceView cDNA sequences (see all 1007):

    BE302011 BC000901 AK128423 AI084870 F08273 AI399704 T03333 CA427646 
    BQ637661 BE018407 BM698048 AU104932 CR613900 AI590129 CA942903 CR612156 
    CN485113 AI955102 BM470455 BM671886 BQ416914 CB130483 CB133165 BQ053605 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CIRBP (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
    SP1:        -     -     -                                   -     -     -     -     -     -               
    SP2:                    -                                   -     -                                       
    SP3:                    -                                                                                 
    SP4:                                                        -     -                                       
    SP5:                                                        -     -     -     -     -                     


    ECgene alternative splicing isoforms for CIRBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CIRBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CIRBP Expression
    About this image

    CIRBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CIRBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.618145

    UniProtKB/Swiss-Prot: CIRBP_HUMAN, Q14011
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for CIRBP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CIRBP
    OriGene qSTAR qPCR primer pairs in human, mouse for CIRBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CIRBP
    QuantiTect SYBR Green Assays in human, mouse, rat CIRBP
    QuantiFast Probe-based Assays in human, mouse, rat CIRBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIRBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CIRBP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cirbp1 , 5 cold inducible RNA binding protein1, 5 86.63(n)1
    95.35(a)1
      10 (39.72 cM)5
    126961  NM_007705.21  NP_031731.11 
     801659855 
    chicken
    (Gallus gallus)
    Aves CIRBP1 cold inducible RNA binding protein 82.44(n)
    95.21(a)
      425789  NM_001031347.1  NP_001026518.1 
    lizard
    (Anolis carolinensis)
    Reptilia CIRBP6
    cold inducible RNA binding protein
    93(a)
    1 ↔ 1
    GL344335.1(55203-58794)
    African clawed frog
    (Xenopus laevis)
    Amphibia cirbp-prov2 cold inducible RNA-binding protein 81.81(n)    BC041204.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb74g052 Danio rerio mRNA similar to cold inducible RNA binding more 78.04(n)    BC048027.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tra26
    transformer 2
    16(a)
    1 → many
    2R(10489509-10491857)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-86
    Protein RSP-8, isoform a
    19(a)
    1 → many
    III(11826215-11831475) WBGene00004705


    ENSEMBL Gene Tree for CIRBP (if available)
    TreeFam Gene Tree for CIRBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CIRBP gene
    RBMY1J2  RBMY1E2  RBMY1F2  TRA2B2  RBMXL22  RBMXL32  RBMY1B2  RBMXL12  
    RBMY1A12  RBM32  RBMX2  TRA2A2  RBMY1D2  
    Selected SIMAP similar genes for CIRBP using alignment to 18 protein entries:     CIRBP_HUMAN (see all proteins) (see all similar genes):
    BOLL    RBM3    RBMY1A1    TIAL1    RBM    RBMX
    MSI2    ZCRB1    DAZAP1    RBM23    RBM42    HNRNPA1
    SRSF2    EIF3G    RNPS1    HNRNPD    ELAVL2    HNRNPA3

    CIRBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CIRBP (see all 43)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846789591,2
    --1272263(+) GGCCCA/GCTGGG 3 -- int1 nc-transcript-variant0--------
    rs1876032101,2
    --1272280(+) GCTAGA/GTGCAT 3 -- int1 nc-transcript-variant0--------
    rs1432050011,2
    C--1272291(+) GTGTGA/GCCGCA 3 -- int1 nc-transcript-variant0--------
    rs1482774981,2
    C--1272339(+) CGGCCA/GCAGGC 3 -- int1 nc-transcript-variant0--------
    rs1413225791,2
    C--1272346(+) AGGCCA/GCGCCC 3 -- int1 nc-transcript-variant0--------
    rs1118285261,2
    C--1272423(+) GTCCTA/C/GAGCTA 5 -- int1 nc-transcript-variant1CSA 1
    rs1114737861,2
    C--1272424(+) TCCTCA/C/TGCTAC 5 -- spa1 nc-transcript-variant1CSA 1
    rs1384946541,2
    C,F--1272430(+) GCTACA/GCACAA 4 T syn12Minor allele frequency- G:0.00NA EU 5873
    rs1999176291,2
    C--1272448(+) AAACCC/TTTCCT 3 -- ut31 nc-transcript-variant0--------
    rs746148841,2
    C--1272451(+) CCCTTC/TCTGCT 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for CIRBP (1259384 - 1274879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CIRBP (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv910476CNV Loss21882294
    dgv3586n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910471CNV Loss21882294
    dgv3591n71CNV Loss21882294
    dgv3595n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    nsv828371CNV Loss20364138
    dgv3575n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CIRBP
    DNA2.0 Custom Variant and Variant Library Synthesis for CIRBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602649    OMIM disorders: --

    7 diseases for CIRBP:    
    About MalaCards
    cryptorchidism    anoxia    endometrial carcinoma    hypoxia
    ataxia    endotheliitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CIRBP:
    Cryptorchidism

    CIRBP for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CIRBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cryptorchidism 44.2 2 9422546 (1), 10793079 (1)
    shock 43.5 14 17967451 (2), 11095679 (1), 10943555 (1), 19277990 (1) (see all 5)
    cancer 0 2 19158277 (1)


    Export disorders for CIRBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CIRBP gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with CIRBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human CIRP (cold-inducible RNA- binding protein) cDNA and chromosomal assignment of the gene. (PubMed id 9434172)1, 2, 3, 9 Nishiyama H.... Fujita J. (Gene 1997)
    2. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. (PubMed id 15075239)1, 2, 9 Wellmann S.... Seeger K. (J. Cell Sci. 2004)
    3. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. (PubMed id 11574538)1, 2, 9 Yang C. and Carrier F. (J. Biol. Chem. 2001)
    4. Post-transcriptional regulation of thioredoxin by the stress inducible heterogeneous ribonucleoprotein A18. (PubMed id 16513844)1, 2 Yang R.... Carrier F. (Nucleic Acids Res. 2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification of several human homologs of hamster DNA damage- inducible transcripts. Cloning and characterization of a novel UV- inducible cDNA that codes for a putative RNA-binding protein. (PubMed id 9334257)1, 2 Sheikh M.S.... Fornace A.J. Jr. (J. Biol. Chem. 1997)
    8. A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. (PubMed id 9151692)1, 3 Nishiyama H....Fujita J. (J. Cell Biol. 1997)
    9. Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. (PubMed id 9422546)1, 9 Nishiyama H....Fujita J. (Am. J. Pathol. 1998)
    10. Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma. (PubMed id 12819390)1, 9 Hamid A.A....Fujii S. (Int. J. Gynecol. Pathol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1153 HGNC: 1982 AceView: CIRBP Ensembl:ENSG00000099622 euGenes: HUgn1153
    ECgene: CIRBP H-InvDB: CIRBP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CIRBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CIRBP gene:
    Search GeneIP for patents involving CIRBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CIRBP  
     OriGene qPCR primer pairs and template standards for CIRBP   OriGene Protein Over-expression Lysate for CIRBP  
     OriGene MassSpec something-or-other for CIRBP   OriGene clones in human, mouse for CIRBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for CIRBP   OriGene Purified Protein for CIRBP  
     OriGene ORF clones in mouse, rat for CIRBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CIRBP   OriGene Custom Protein Services for CIRBP  

     
     
     Block miRNA regulation of human, mouse, rat CIRBP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CIRBP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIRBP Predesigned siRNA for gene silencing in human, mouse, rat CIRBP
     QuantiFast Probe-based Assays in human, mouse, rat CIRBP QuantiTect SYBR Green Assays in human, mouse, rat CIRBP
     Custom PCR Arrays for CIRBP Search Chromatin IP Primers for CIRBP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CIRBP  Search GeneGlobe Interaction Network for CIRBP
     Regulatory tfbs in CIRBP promoter
     GenScript Custom Purified and Recombinant Proteins Services for CIRBP GenScript cDNA clones with any tag delivered in your preferred vector for CIRBP
     GenScript Custom Assay Services for CIRBP GenScript Custom overexpressing Cell Line Services for CIRBP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CIRBP
     Proteins for CIRBP
     Browse Sino Biological Cell Lysates
     cDNA Clones for CIRBP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CIRBP antibodies
     CIRBP proteins
     CIRBP lysates
     Antibodies for CIRBP
     See all of Abcam's Antibodies, Kits and Proteins for CIRBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CIRBP
     Proteins for CIRBP
     Antibodies for CIRBP
     ELISAs for CIRBP
     CLIAs for CIRBP



     Browse ESI BIO Cell Lines and PureStem Progenitors for CIRBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIRBP
     SwitchGear 3'UTR luciferase reporter plasmids for CIRBP
     SwitchGear Promoter luciferase reporter plasmids for CIRBP
     ThermoFisher Antibody for CIRBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIRBP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIRBP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CIRBP
     LSBio Antibodies in human, mouse, rat for CIRBP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CIRBP gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4