Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CIR1 Gene

protein-coding   GIFtS: 54
GCID: GC02M175212

Corepressor Interacting With RBPJ, 1

  Search for CIR1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Corepressor Interacting With RBPJ, 11 2     CBF1-Interacting Corepressor2 3
CBF1 Interacting Corepressor1 2     Corepressor Interacting With RBPJ 12
recepin1 2     Recepin3
CIR2 3     

External Ids:    HGNC: 242171   Entrez Gene: 95412   Ensembl: ENSG000001384337   OMIM: 6052285   UniProtKB: Q86X953   

Export aliases for CIR1 gene to outside databases

Previous GC identifers: GC02M174922 GC02M167093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CIR1 Gene:
CIR1 (corepressor interacting with RBPJ, 1) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: CIR1_HUMAN, Q86X95
Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates
transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC).
Required for RBPJ-mediated repression of transcription

Gene Wiki entry for CIR1 (CIR) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CIR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCIR1 promoter sequence
   Search Chromatin IP Primers for CIR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

CIR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M175212:  view genomic region     (about GC identifiers)

Start:
175,212,750 bp from pter      End:
175,260,443 bp from pter
Size:
47,694 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CIR1_HUMAN, Q86X95 (See protein sequence)
Recommended Name: Corepressor interacting with RBPJ 1  
Size: 450 amino acids; 52313 Da
Subunit: Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with
Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor
complex
Sequence caution: Sequence=AAA17853.1; Type=Frameshift; Positions=135, 151, 177, 203, 261, 299, 391, 410;
Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: A6NFI6 A8K8M4 O95367 Q12804 Q4G1B9 Q6PJI4 Q8IWI2
Alternative splicing: 2 isoforms:  Q86X95-1   Q86X95-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CIR1: NX_Q86X95

Explore proteomics data for CIR1 at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK61
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CIR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004873.3  
    ENSEMBL proteins: 
     ENSP00000339723   ENSP00000367211   ENSP00000355034  

    CIR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CIR1
    GenScript Custom Purified and Recombinant Proteins Services for CIR1
    Novus Biologicals CIR1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CIR1 

    CIR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CIR1
    Novus Biologicals CIR1 Antibodies
    Search for Antibodies for CIR1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CIR1
    LSBio Antibodies in human, mouse, rat for CIR1

    CIR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CIR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CIR1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CIR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR019339 CIR_N_dom

    Graphical View of Domain Structure for InterPro Entry Q86X95

    ProtoNet protein and cluster: Q86X95


    Find genes that share domains with CIR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIR1_HUMAN, Q86X95
    Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates
    transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC).
    Required for RBPJ-mediated repression of transcription

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9874765
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS18663143
    GO:0003714transcription corepressor activity TAS9874765
    GO:0005515protein binding IPI15652350
         
    Find genes that share ontologies with CIR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CIR1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CIR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIR1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CIR1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CIR1:
    hsa-miR-138-1* hsa-miR-589*
    SwitchGear 3'UTR luciferase reporter plasmidCIR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CIR1
    Predesigned siRNA for gene silencing in human, mouse, rat CIR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CIR1

    Clone
    Products:
         
    OriGene clones in human, mouse for CIR1 (see all 7)
    OriGene ORF clones in mouse, rat for CIR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIR1 (NM_004882)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CIR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CIR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CIR1_HUMAN, Q86X95: Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=Colocalizes with NEK6 in the centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118colocalizes with histone deacetylase complex IDA9874765
    GO:0005634nucleus IDA9874765
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with CIR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CIR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    2Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Development Notch Signaling Pathway0.50
    3Notch Signaling Pathways
    Notch Signaling Pathways


    Find genes that share SuperPaths with CIR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CIR1
        Notch Signaling Pathways


    2 GeneGo (Thomson Reuters) Pathways for CIR1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway

    1 BioSystems Pathway for CIR1
        Delta-Notch Signaling Pathway


    1 Kegg Pathway  (Kegg details for CIR1):
        Notch signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CIR1
    Interactions:

        Search GeneGlobe Interaction Network for CIR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CIR1 (Q86X951, 2, 3 ENSP000003397234) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF2Q011301, 3, ENSP000003508774EBI-627102,EBI-627047 I2D: score=3 STRING: ENSP00000350877
    SRSF1Q079551, 3, ENSP000002589624EBI-627102,EBI-398920 I2D: score=2 STRING: ENSP00000258962
    U2AF1Q010811, 3, ENSP000002915524EBI-627102,EBI-632461 I2D: score=2 STRING: ENSP00000291552
    RBPJQ063303, ENSP000003452064I2D: score=4 STRING: ENSP00000345206
    SAP30O754463, ENSP000002965044I2D: score=4 STRING: ENSP00000296504
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS18663143
    GO:0006366transcription from RNA polymerase II promoter TAS18663143
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA9874765

    Find genes that share ontologies with CIR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CIR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CIR1 gene (2 alternative transcripts): 
    NM_199075.1  NM_004882.3  

    Unigene Cluster for CIR1:

    Corepressor interacting with RBPJ, 1
    Hs.632531  [show with all ESTs]
    Unigene Representative Sequence: NM_004882
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342016(uc002uim.3 uc002uin.3) ENST00000464393 ENST00000377973
    ENST00000461454 ENST00000472169 ENST00000362053
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CIR1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CIR1:
    hsa-miR-138-1* hsa-miR-589*
    SwitchGear 3'UTR luciferase reporter plasmidCIR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CIR1
    Predesigned siRNA for gene silencing in human, mouse, rat CIR1
    Clone
    Products:
         
    OriGene clones in human, mouse for CIR1 (see all 7)
    OriGene ORF clones in mouse, rat for CIR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIR1 (NM_004882)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CIR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CIR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CIR1
      QuantiTect SYBR Green Assays in human, mouse, rat CIR1
      QuantiFast Probe-based Assays in human, mouse, rat CIR1

    Additional mRNA sequence: 

    AF098297.1 AK292389.1 BC021175.1 BC031018.1 BC038987.1 BC046098.2 U03644.1 

    10 DOTS entries:

    DT.453273  DT.75137806  DT.65288434  DT.120970670  DT.95169366  DT.100806759  DT.120970634  DT.91733404 
    DT.91733402  DT.95097886 

    Selected AceView cDNA sequences (see all 178):

    CA427940 CR593259 CA771245 BF476108 BU159244 CB139582 AI358035 CF143339 
    CD366894 BX110332 CA426263 AA199649 BP340084 AI379132 CA771553 CD365426 
    BQ021544 CR611416 BF110810 AW590080 BU618011 AI307302 N71888 CB528586 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CIR1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -                             -                                 
    SP2:                    -                             -     -                           
    SP3:                    -                                                               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CIR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CIR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACACAGA
    CIR1 Expression
    About this image

    CIR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CIR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632531

    UniProtKB/Swiss-Prot: CIR1_HUMAN, Q86X95
    Tissue specificity: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas

        Custom PCR Arrays for CIR1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CIR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CIR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CIR1
    QuantiTect SYBR Green Assays in human, mouse, rat CIR1
    QuantiFast Probe-based Assays in human, mouse, rat CIR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CIR1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cir11 , 5 corepressor interacting with RBPJ, 11, 5 91(n)1
    98.23(a)1
      2 (43.54 cM)5
    669351  NM_025854.31  NP_080130.21 
     732831055 
    chicken
    (Gallus gallus)
    Aves CIR11 corepressor interacting with RBPJ, 1 75.53(n)
    72.07(a)
      426529  NM_001031386.1  NP_001026557.1 
    lizard
    (Anolis carolinensis)
    Reptilia CIR16
    corepressor interacting with RBPJ, 1
    71(a)
    1 ↔ 1
    GL343377.1(975981-1024283)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.220702 Xenopus laevis transcribed sequence with moderate similarity more 85.75(n)    BX852242.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-167c12.21 si:ch73-167c12.2 76.07(n)
    85.26(a)
      553421  XM_683925.6  XP_689017.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68436
    --
    42(a)
    1 ↔ 1
    3L(18894694-18896052)
    worm
    (Caenorhabditis elegans)
    Secernentea cir-16
    Protein CIR-1 (cir-1) mRNA, complete cds
    30(a)
    1 ↔ 1
    I(5653802-5655857) WBGene00018892


    ENSEMBL Gene Tree for CIR1 (if available)
    TreeFam Gene Tree for CIR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CIR1 gene
    10 SIMAP similar genes for CIR1 using alignment to 2 protein entries:     CIR1_HUMAN (see all proteins):
    A4GALT    CIR    HSPA9    C8orf17    METTL2B    ATP8B3
    SNTB2    C8orf44    ELMOD3    STARD10

    Find genes that share paralogs with CIR1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CIR1
    PGOHUM00000242635 PGOHUM00000245663 PGOHUM00000235431


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CIR1 (see all 877)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44324171,2
    C--175212388(+) CCATGC/GTGGAG 1 -- int12Minor allele frequency- G:0.25NA 4
    rs1142253391,2
    F--175212486(+) ACACTG/CCATGC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1845754921,2
    --175212498(+) ACCATA/GCCCAG 1 -- int10--------
    rs1130179201,2
    C,F--175212533(+) CACGGG/AGTTTC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1139968771,2
    C,F--175212562(+) GTCTCG/AAAACT 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1490974781,2
    C--175212744(+) CTAAA-/GGGGGC 1 -- int10--------
    rs1902408051,2
    --175212776(+) TAATCC/TTTAAT 1 -- int10--------
    rs739751131,2
    C,F--175212863(+) AAAAAA/TGTAAA 1 -- int13Minor allele frequency- T:0.23WA CSA 122
    rs1815076231,2
    --175212937(+) AGTTAC/TATGCG 1 -- ut310--------
    rs1453225791,2
    C--175212942(+) TATGCA/GGTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CIR1 (175212750 - 175260443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CIR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875421CNV Loss21882294
    dgv4366n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CIR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CIR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605228    OMIM disorders: --


    Find genes that share disorders with CIR1           About GenesLikeMe


    Export disorders for CIR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CIR1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CIR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. (PubMed id 11222720)1, 2, 3 Zhang J.... Hayward S.D. (J. Virol. 2001)
    2. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. (PubMed id 9874765)1, 2, 3 Hsieh J.J.-D.... Hayward S.D. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)1, 2 Vaz Meirelles G.... Kobarg J. (J. Proteome Res. 2010)
    4. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. (PubMed id 19409814)1, 2 Pajerowski A.G.... Shapiro V.S. (Immunity 2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. (PubMed id 15652350)1, 3 Maita H....Iguchi-Ariga S.M. (Exp. Cell Res. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A role for SKIP in EBNA2 activation of CBF1-repressed promoters. (PubMed id 10644367)1, 2 Zhou S.... Hayward S.D. (J. Virol. 2000)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9541 HGNC: 24217 AceView: CIR Ensembl:ENSG00000138433 euGenes: HUgn9541
    ECgene: CIR1 Kegg: 9541 H-InvDB: CIR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CIR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CIR1 gene:
    Search GeneIP for patents involving CIR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CIR1  
     OriGene qPCR primer pairs and template standards for CIR1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CIR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CIR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CIR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CIR1   OriGene Custom Protein Services for CIR1  

     
     
     Block miRNA regulation of human, mouse, rat CIR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CIR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CIR1 Predesigned siRNA for gene silencing in human, mouse, rat CIR1
     QuantiFast Probe-based Assays in human, mouse, rat CIR1 QuantiTect SYBR Green Assays in human, mouse, rat CIR1
     Custom PCR Arrays for CIR1 Search Chromatin IP Primers for CIR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CIR1  Search GeneGlobe Interaction Network for CIR1
     Search Regulatory tfbs for CIR1
     GenScript Custom Purified and Recombinant Proteins Services for CIR1 GenScript cDNA clones with any tag delivered in your preferred vector for CIR1
     GenScript Custom Assay Services for CIR1 GenScript Custom overexpressing Cell Line Services for CIR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CIR1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CIR1 antibodies
     CIR1 proteins
     Search for Antibodies for CIR1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CIR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CIR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIR1
     SwitchGear 3'UTR luciferase reporter plasmids for CIR1
     SwitchGear Promoter luciferase reporter plasmids for CIR1
     ThermoFisher Antibodies for CIR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIR1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CIR1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CIR1
     LSBio Antibodies in human, mouse, rat for CIR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CIR1
      Search eBioscience for proteins for CIR1
      Search eBioscience for elisas for CIR1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CIR1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4