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Aliases for CIR1 Gene

Aliases for CIR1 Gene

  • Corepressor Interacting With RBPJ, 1 2 3 5
  • Recepin 2 3 4
  • CBF1 Interacting Corepressor 2 3
  • CBF1-Interacting Corepressor 3 4
  • CIR 3 4

External Ids for CIR1 Gene

Previous GeneCards Identifiers for CIR1 Gene

  • GC02M174922
  • GC02M175212
  • GC02M167093

Summaries for CIR1 Gene

GeneCards Summary for CIR1 Gene

CIR1 (Corepressor Interacting With RBPJ, 1) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include nucleic acid binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for CIR1 Gene

  • May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Gene Wiki entry for CIR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIR1 Gene

Genomics for CIR1 Gene

Regulatory Elements for CIR1 Gene

Promoters for CIR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CIR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CIR1 Gene

Chromosome:
2
Start:
174,348,022 bp from pter
End:
174,395,715 bp from pter
Size:
47,694 bases
Orientation:
Minus strand

Genomic View for CIR1 Gene

Genes around CIR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIR1 Gene

Proteins for CIR1 Gene

  • Protein details for CIR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X95-CIR1_HUMAN
    Recommended name:
    Corepressor interacting with RBPJ 1
    Protein Accession:
    Q86X95
    Secondary Accessions:
    • A6NFI6
    • A8K8M4
    • O95367
    • Q12804
    • Q4G1B9
    • Q6PJI4
    • Q8IWI2

    Protein attributes for CIR1 Gene

    Size:
    450 amino acids
    Molecular mass:
    52313 Da
    Quaternary structure:
    • Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex.
    SequenceCaution:
    • Sequence=AAA17853.1; Type=Frameshift; Positions=135, 151, 177, 203, 261, 299, 391, 410; Evidence={ECO:0000305}; Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for CIR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIR1 Gene

Proteomics data for CIR1 Gene at MOPED

Post-translational modifications for CIR1 Gene

Other Protein References for CIR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CIR1 Gene

Domains & Families for CIR1 Gene

Protein Domains for CIR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CIR1 Gene

Function for CIR1 Gene

Molecular function for CIR1 Gene

UniProtKB/Swiss-Prot Function:
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
genes like me logo Genes that share phenotypes with CIR1: view

Animal Models for CIR1 Gene

MGI Knock Outs for CIR1:
  • Cir1 tm3a(KOMP)Wtsi

Animal Model Products

miRNA for CIR1 Gene

miRTarBase miRNAs that target CIR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIR1 Gene

Localization for CIR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIR1 Gene

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIR1 Gene COMPARTMENTS Subcellular localization image for CIR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for CIR1 Gene

Pathways & Interactions for CIR1 Gene

genes like me logo Genes that share pathways with CIR1: view

Pathways by source for CIR1 Gene

1 BioSystems pathway for CIR1 Gene
1 KEGG pathway for CIR1 Gene
1 R&D Systems pathway for CIR1 Gene

SIGNOR curated interactions for CIR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 9874765
genes like me logo Genes that share ontologies with CIR1: view

Drugs & Compounds for CIR1 Gene

No Compound Related Data Available

Transcripts for CIR1 Gene

Unigene Clusters for CIR1 Gene

Corepressor interacting with RBPJ, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CIR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CIR1 Gene

GeneLoc Exon Structure for
CIR1
ECgene alternative splicing isoforms for
CIR1

Expression for CIR1 Gene

mRNA expression in normal human tissues for CIR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CIR1 Gene

This gene is overexpressed in Cerebrospinal fluid (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIR1 Gene



SOURCE GeneReport for Unigene cluster for CIR1 Gene Hs.632531

mRNA Expression by UniProt/SwissProt for CIR1 Gene

Q86X95-CIR1_HUMAN
Tissue specificity: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expression patterns with CIR1: view

Protein tissue co-expression partners for CIR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CIR1 Gene

Orthologs for CIR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CIR1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CIR1 35
  • 87.75 (n)
  • 85.08 (a)
mouse
(Mus musculus)
Mammalia Cir1 35
  • 91 (n)
  • 98.23 (a)
Cir1 16
Cir1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CIR1 35
  • 99.7 (n)
  • 99.56 (a)
CIR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cir1 35
  • 75.62 (n)
  • 75.23 (a)
cow
(Bos Taurus)
Mammalia CIR1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIR1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CIR1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CIR1 35
  • 75.53 (n)
  • 72.07 (a)
CIR1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CIR1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22070 35
zebrafish
(Danio rerio)
Actinopterygii si:ch73-167c12.2 35
  • 76.07 (n)
  • 85.26 (a)
CIR1 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6843 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cir-1 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 38
Species with no ortholog for CIR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CIR1 Gene

ENSEMBL:
Gene Tree for CIR1 (if available)
TreeFam:
Gene Tree for CIR1 (if available)

Paralogs for CIR1 Gene

(10) SIMAP similar genes for CIR1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CIR1 Gene

genes like me logo Genes that share paralogs with CIR1: view

No data available for Paralogs for CIR1 Gene

Variants for CIR1 Gene

Sequence variations from dbSNP and Humsavar for CIR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1063618 -- 174,348,876(-) TAGCA(C/G)TCACC reference, missense
rs2122398 -- 174,385,561(+) ttgat(G/T)ccaat intron-variant
rs2167133 -- 174,369,140(+) aacta(A/C)cttca intron-variant
rs2167134 -- 174,385,376(+) ACAGT(A/C)CTTTT intron-variant
rs2167135 -- 174,385,437(+) GCATT(C/T)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIR1 Gene

Variant ID Type Subtype PubMed ID
nsv875421 CNV Loss 21882294
dgv4366n71 CNV Loss 21882294

Variation tolerance for CIR1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIR1 Gene

HapMap Linkage Disequilibrium report
CIR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIR1 Gene

Disorders for CIR1 Gene

Relevant External Links for CIR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIR1

No disorders were found for CIR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIR1 Gene

Publications for CIR1 Gene

  1. Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. (PMID: 11222720) Zhang J. … Hayward S.D. (J. Virol. 2001) 2 3 4 67
  2. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. (PMID: 15652350) Maita H. … Iguchi-Ariga S.M. (Exp. Cell Res. 2005) 2 3
  3. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. (PMID: 9874765) Hsieh J.J.-D. … Hayward S.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3

Products for CIR1 Gene

Sources for CIR1 Gene

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