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Aliases for CIR1 Gene

Aliases for CIR1 Gene

  • Corepressor Interacting With RBPJ, 1 2 3 5
  • Recepin 2 3 4
  • CBF1-Interacting Corepressor 3 4
  • CIR 3 4
  • Corepressor Interacting With RBPJ 1 3
  • CBF1 Interacting Corepressor 2

External Ids for CIR1 Gene

Previous GeneCards Identifiers for CIR1 Gene

  • GC02M174922
  • GC02M175212
  • GC02M167093

Summaries for CIR1 Gene

GeneCards Summary for CIR1 Gene

CIR1 (Corepressor Interacting With RBPJ, 1) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include nucleic acid binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for CIR1 Gene

  • May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Gene Wiki entry for CIR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIR1 Gene

Genomics for CIR1 Gene

Regulatory Elements for CIR1 Gene

Enhancers for CIR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G174585 1.7 FANTOM5 ENCODE dbSUPER 8.5 -197.9 -197900 17.0 HDGF PKNOX1 FOXA2 ARNT MLX WRNIP1 SIN3A ARID4B FEZF1 ZBTB7B WIPF1 CIR1 GPR155 ENSG00000237798 GC02P174645
GH02G173988 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +405.0 405012 4.2 CTCF TAF1 MAX RAD21 RELA YY1 ZNF316 POLR2A EED MAFK SP3 ENSG00000273258 CIR1 ENSG00000271151
GH02G174605 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -213.4 -213382 6.5 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A RAD21 RARA FOS RELB WIPF1 ENSG00000237798 CIR1 GC02P174645
GH02G174492 1.3 FANTOM5 Ensembl ENCODE 1.7 -98.0 -97994 3.4 HDGF TBP MXI1 TBL1XR1 RBBP5 YY1 ARID3A ZNF207 RELB IKZF2 WIPF1 GPR155 CIR1 GC02M174489 LOC442058
GH02G174775 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.1 -382.5 -382504 5.5 FOXA2 BMI1 FOS IKZF2 CREM CEBPB GATAD2B SP1 SMARCA4 RFX3 CHN1 ATP5G3 CIR1 LOC105373750 H3F3AP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CIR1 on UCSC Golden Path with GeneCards custom track

Promoters for CIR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126573 115 2001 HDGF PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for CIR1 Gene

Chromosome:
2
Start:
174,348,022 bp from pter
End:
174,395,715 bp from pter
Size:
47,694 bases
Orientation:
Minus strand

Genomic View for CIR1 Gene

Genes around CIR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIR1 Gene

Proteins for CIR1 Gene

  • Protein details for CIR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X95-CIR1_HUMAN
    Recommended name:
    Corepressor interacting with RBPJ 1
    Protein Accession:
    Q86X95
    Secondary Accessions:
    • A6NFI6
    • A8K8M4
    • O95367
    • Q12804
    • Q4G1B9
    • Q6PJI4
    • Q8IWI2

    Protein attributes for CIR1 Gene

    Size:
    450 amino acids
    Molecular mass:
    52313 Da
    Quaternary structure:
    • Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with NKAPL (By similarity).
    SequenceCaution:
    • Sequence=AAA17853.1; Type=Frameshift; Positions=135, 151, 177, 203, 261, 299, 391, 410; Evidence={ECO:0000305}; Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for CIR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIR1 Gene

Post-translational modifications for CIR1 Gene

Other Protein References for CIR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CIR1 Gene

Domains & Families for CIR1 Gene

Protein Domains for CIR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CIR1 Gene

Function for CIR1 Gene

Molecular function for CIR1 Gene

UniProtKB/Swiss-Prot Function:
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Gene Ontology (GO) - Molecular Function for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9874765
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS 18663143
GO:0003714 transcription corepressor activity TAS 9874765
GO:0005515 protein binding IPI 9874765
genes like me logo Genes that share ontologies with CIR1: view
genes like me logo Genes that share phenotypes with CIR1: view

Animal Models for CIR1 Gene

MGI Knock Outs for CIR1:
  • Cir1 tm3a(KOMP)Wtsi

Animal Model Products

CRISPR Products

miRNA for CIR1 Gene

miRTarBase miRNAs that target CIR1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIR1 Gene

Localization for CIR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIR1 Gene

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 9874765
GO:0005634 nucleus IEA,IDA 9874765
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CIR1: view

Pathways & Interactions for CIR1 Gene

genes like me logo Genes that share pathways with CIR1: view

Pathways by source for CIR1 Gene

1 BioSystems pathway for CIR1 Gene
1 KEGG pathway for CIR1 Gene
1 R&D Systems pathway for CIR1 Gene

SIGNOR curated interactions for CIR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with CIR1: view

Drugs & Compounds for CIR1 Gene

No Compound Related Data Available

Transcripts for CIR1 Gene

Unigene Clusters for CIR1 Gene

Corepressor interacting with RBPJ, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CIR1 Gene

GeneLoc Exon Structure for
CIR1
ECgene alternative splicing isoforms for
CIR1

Expression for CIR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CIR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CIR1 Gene

This gene is overexpressed in Cerebrospinal fluid (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CIR1 Gene



Protein tissue co-expression partners for CIR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CIR1 Gene:

CIR1

SOURCE GeneReport for Unigene cluster for CIR1 Gene:

Hs.632531

mRNA Expression by UniProt/SwissProt for CIR1 Gene:

Q86X95-CIR1_HUMAN
Tissue specificity: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for CIR1 Gene

  • Liver(4.2)
  • Eye(4)
  • Lung(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CIR1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIR1 Gene

Orthologs for CIR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CIR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIR1 34 35
  • 99.7 (n)
mouse
(Mus musculus)
Mammalia Cir1 34 16 35
  • 91 (n)
dog
(Canis familiaris)
Mammalia CIR1 34
  • 87.75 (n)
cow
(Bos Taurus)
Mammalia CIR1 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CIR1 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cir1 34
  • 75.62 (n)
oppossum
(Monodelphis domestica)
Mammalia CIR1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CIR1 34 35
  • 75.53 (n)
lizard
(Anolis carolinensis)
Reptilia CIR1 35
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22070 34
zebrafish
(Danio rerio)
Actinopterygii CIR1 35
  • 84 (a)
OneToOne
si:ch73-167c12.2 34
  • 76.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6843 35
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cir-1 35
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 37
Species where no ortholog for CIR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CIR1 Gene

ENSEMBL:
Gene Tree for CIR1 (if available)
TreeFam:
Gene Tree for CIR1 (if available)

Paralogs for CIR1 Gene

(10) SIMAP similar genes for CIR1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CIR1 Gene

genes like me logo Genes that share paralogs with CIR1: view

No data available for Paralogs for CIR1 Gene

Variants for CIR1 Gene

Sequence variations from dbSNP and Humsavar for CIR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000022845 -- 174,375,880(+) TTTTG(A/T)GATAG intron-variant
rs1000053905 -- 174,396,494(+) TCAGG(A/G)TAATG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000054265 -- 174,372,503(+) CATTA(A/C)GAAAT intron-variant
rs1000070744 -- 174,365,440(+) CAGTT(A/C)TCTTT intron-variant
rs1000265773 -- 174,393,236(+) TGTAA(A/G)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIR1 Gene

Variant ID Type Subtype PubMed ID
esv3584179 CNV loss 25503493

Variation tolerance for CIR1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIR1 Gene

Disorders for CIR1 Gene

Relevant External Links for CIR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIR1

No disorders were found for CIR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIR1 Gene

Publications for CIR1 Gene

  1. Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. (PMID: 11222720) Zhang J. … Hayward S.D. (J. Virol. 2001) 2 3 4 64
  2. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. (PMID: 9874765) Hsieh J.J.-D. … Hayward S.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 64
  3. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3 4 64
  4. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. (PMID: 19409814) Pajerowski A.G. … Shapiro V.S. (Immunity 2009) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for CIR1 Gene

Sources for CIR1 Gene

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