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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CIR1 Gene

protein-coding   GIFtS: 55
GCID: GC02M175212

Corepressor Interacting With RBPJ, 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Corepressor Interacting With RBPJ, 11 2     CBF1-Interacting Corepressor2 3
CBF1 Interacting Corepressor1 2     Corepressor Interacting With RBPJ 12
recepin1 2     Recepin3
CIR2 3     

External Ids:    HGNC: 242171   Entrez Gene: 95412   Ensembl: ENSG000001384337   OMIM: 6052285   UniProtKB: Q86X953   

Export aliases for CIR1 gene to outside databases

Previous GC identifers: GC02M174922 GC02M167093


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CIR1 Gene: 
CIR1 (corepressor interacting with RBPJ, 1) is a protein-coding gene. Diseases associated with CIR1 include cryptococcosis, and meningoencephalitis, and among its related super-pathways are Notch signaling pathway and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: CIR1_HUMAN, Q86X95
Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates
transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC).
Required for RBPJ-mediated repression of transcription

Gene Wiki entry for CIR1 (CIR) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CIR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCIR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CIR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CIR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

CIR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CIR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M175212:  view genomic region     (about GC identifiers)

Start:
175,212,750 bp from pter      End:
175,260,443 bp from pter
Size:
47,694 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CIR1_HUMAN, Q86X95 (See protein sequence)
Recommended Name: Corepressor interacting with RBPJ 1  
Size: 450 amino acids; 52313 Da
Subunit: Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with
Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor
complex
Subcellular location: Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Note=Co-localizes with NEK6 in the centrosome
Sequence caution: Sequence=AAA17853.1; Type=Frameshift; Positions=135, 151, 177, 203, 261, 299, 391, 410;
Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: A6NFI6 A8K8M4 O95367 Q12804 Q4G1B9 Q6PJI4 Q8IWI2
Alternative splicing: 2 isoforms:  Q86X95-1   Q86X95-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CIR1: NX_Q86X95

Explore proteomics data for CIR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by NEK6
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86X95

  • CIR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CIR1 Protein Expression
    REFSEQ proteins: NP_004873.3  
    ENSEMBL proteins: 
     ENSP00000339723   ENSP00000367211   ENSP00000355034  

    Human Recombinant Protein Products for CIR1: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CIR1
    GenScript Custom Purified and Recombinant Proteins Services for CIR1
    Novus Biologicals CIR1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118colocalizes with histone deacetylase complex IDA9874765
    GO:0005634nucleus IDA9874765
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0016607nuclear speck IEA--

    CIR1 for ontologies           About GeneDecksing



    CIR1 Antibody Products: 
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    Novus Biologicals CIR1 Antibodies
    Abcam antibodies for CIR1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CIR1
    LSBio Antibodies in human, mouse, rat for CIR1 

    Assay Products for CIR1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CIR1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019339 CIR_N_dom

    Graphical View of Domain Structure for InterPro Entry Q86X95

    ProtoNet protein and cluster: Q86X95


    CIR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIR1_HUMAN, Q86X95
    Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates
    transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC).
    Required for RBPJ-mediated repression of transcription

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9874765
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS18663143
    GO:0003714transcription corepressor activity TAS9874765
    GO:0005515protein binding IPI15652350
         
    CIR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CIR1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CIR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CIR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CIR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CIR1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIR1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CIR1:
    hsa-miR-138-1* hsa-miR-589*
    SwitchGear 3'UTR luciferase reporter plasmidCIR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CIR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CIR1
    Sirion Biotech Customized adenovirus for overexpression of CIR1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CIR1 (see all 5)
    OriGene ORF clones in mouse, rat for CIR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIR1 (NM_004882)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIR1
    Sirion Biotech Customized lentivirus for stable overexpression of CIR1 
                         Customized lentivirus expression plasmids for stable overexpression of CIR1 

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    Search LifeMap BioReagents cell lines for CIR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CIR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Development Notch Signaling Pathway0.54
    3Notch Signaling Pathways
    Notch Signaling Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CIR1
        Development Notch Signaling Pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    1 R&D Systems Pathway for CIR1
        Notch Signaling Pathways


    2 GeneGo (Thomson Reuters) Pathways for CIR1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway

    1 BioSystems Pathway for CIR1
        Delta-Notch Signaling Pathway


    1         Kegg Pathway  (Kegg details for CIR1):
        Notch signaling pathway


    CIR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CIR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/21 Interacting proteins for CIR1 (Q86X951, 2, 3 ENSP000003397234) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF2Q011301, 3, ENSP000003508774EBI-627102,EBI-627047 I2D: score=3 STRING: ENSP00000350877
    SRSF1Q079551, 3, ENSP000002589624EBI-627102,EBI-398920 I2D: score=2 STRING: ENSP00000258962
    U2AF1Q010811, 3, ENSP000002915524EBI-627102,EBI-632461 I2D: score=2 STRING: ENSP00000291552
    RBPJQ063303, ENSP000003452064I2D: score=4 STRING: ENSP00000345206
    SAP30O754463, ENSP000002965044I2D: score=4 STRING: ENSP00000296504
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA9874765

    CIR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CIR1

    Search CenterWatch for drugs/clinical trials and news about CIR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CIR1 gene (2 alternative transcripts): 
    NM_199075.1  NM_004882.3  

    Unigene Cluster for CIR1:

    Corepressor interacting with RBPJ, 1
    Hs.632531  [show with all ESTs]
    Unigene Representative Sequence: NM_004882
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342016(uc002uim.3 uc002uin.3) ENST00000464393 ENST00000377973
    ENST00000461454 ENST00000472169 ENST00000362053
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CIR1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CIR1:
    hsa-miR-138-1* hsa-miR-589*
    SwitchGear 3'UTR luciferase reporter plasmidCIR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CIR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CIR1
    Clone
    Products:
         
    OriGene clones in human, mouse for CIR1 (see all 5)
    OriGene ORF clones in mouse, rat for CIR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CIR1 (NM_004882)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CIR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CIR1
    Sirion Biotech Customized lentivirus for stable overexpression of CIR1 
                         Customized lentivirus expression plasmids for stable overexpression of CIR1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CIR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CIR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CIR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIR1

    Additional mRNA sequence: 

    AF098297.1 AK292389.1 BC021175.1 BC031018.1 BC038987.1 BC046098.2 U03644.1 

    10 DOTS entries:

    DT.453273  DT.75137806  DT.65288434  DT.120970670  DT.95169366  DT.100806759  DT.120970634  DT.91733404 
    DT.91733402  DT.95097886 

    24/178 AceView cDNA sequences (see all 178):

    AI358035 BM768822 AI379132 BF476108 BX110332 CF143339 CD365378 CR593259 
    AI307302 CA437939 CF528529 CD366894 CA426263 CA427940 BP340084 CR601497 
    CA771245 CR611416 CD677409 BU618011 CR599038 CA771553 BU159244 CD365426 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CIR1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -                             -                                 
    SP2:                    -                             -     -                           
    SP3:                    -                                                               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CIR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CIR1 expression in normal human tissues (normalized intensities)      CIR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACACAGA
    CIR1 Expression
    About this image


    CIR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             monocyte-derived macrophage   
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Endothelium (Cardiovascular System)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Testis (Reproductive System)

    See CIR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CIR1

    SOURCE GeneReport for Unigene cluster: Hs.632531

    UniProtKB/Swiss-Prot: CIR1_HUMAN, Q86X95
    Tissue specificity: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas

        SABiosciences Custom PCR Arrays for CIR1
    Primer
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    OriGene qPCR primer pairs and template standards for CIR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CIR1
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CIR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CIR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CIR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CIR1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cir11 , 5 corepressor interacting with RBPJ, 11, 5 82.56(n)1
    81.86(a)1
      2 (43.54 cM)5
    669351  NM_025854.31  NP_080130.21 
     732831055 
    chicken
    (Gallus gallus)
    Aves CIR11 corepressor interacting with RBPJ, 1 77.3(n)
    75.11(a)
      426529  NM_001031386.1  NP_001026557.1 
    lizard
    (Anolis carolinensis)
    Reptilia CIR16
    corepressor interacting with RBPJ, 1
    69(a)
    1 ↔ 1
    GL343377.1(975981-1024283)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.220702 Xenopus laevis transcribed sequence with moderate similarity more 85.75(n)    BX852242.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-167c12.21 si:ch73-167c12.2 75.68(n)
    84.28(a)
      553421  XM_683925.5  XP_689017.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68431 CG6843 52(n)
    45.81(a)
      40062  NM_140815.2  NP_649072.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cir-11 Protein CIR-1 49.39(n)
    43.49(a)
      172225  NM_059253.3  NP_491654.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G191901 uncharacterized zinc finger CCHC domain-containing more 44.7(n)
    32.05(a)
      827658  NM_118039.4  NP_193654.2 


    ENSEMBL Gene Tree for CIR1 (if available)
    TreeFam Gene Tree for CIR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CIR1 gene
    10 SIMAP similar genes for CIR1 using alignment to 2 protein entries:     CIR1_HUMAN (see all proteins):
    A4GALT    CIR    HSPA9    C8orf17    METTL2B    ATP8B3
    SNTB2    C8orf44    ELMOD3    STARD10

    CIR1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CIR1
    PGOHUM00000242635 PGOHUM00000245663 PGOHUM00000235431


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/877 SNPs in CIR1 are shown (see all 877)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44324171,2
    C--175212388(+) CCATGC/GTGGAG 1 -- int12Minor allele frequency- G:0.25NA 4
    rs1142253391,2
    F--175212486(+) ACACTG/CCATGC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1845754921,2
    --175212498(+) ACCATA/GCCCAG 1 -- int10--------
    rs1130179201,2
    C,F--175212533(+) CACGGG/AGTTTC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1139968771,2
    C,F--175212562(+) GTCTCG/AAAACT 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1490974781,2
    C--175212744(+) CTAAA-/GGGGGC 1 -- int10--------
    rs1902408051,2
    --175212776(+) TAATCC/TTTAAT 1 -- int10--------
    rs739751131,2
    C,F--175212863(+) AAAAAA/TGTAAA 1 -- int13Minor allele frequency- T:0.23WA CSA 122
    rs1815076231,2
    --175212937(+) AGTTAC/TATGCG 1 -- ut310--------
    rs1453225791,2
    C--175212942(+) TATGCA/GGTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CIR1 (175212750 - 175260443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CIR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv875421CNV Loss21882294
    dgv4366n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605228    OMIM disorders: --

    3 diseases for CIR1:    About MalaCards
    cryptococcosis    meningoencephalitis    meningitis


    CIR1 for disorders           About GeneDecksing


    Export disorders for CIR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CIR1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CIR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. (PubMed id 11222720)1, 2, 3 Zhang J.... Hayward S.D. (2001)
    2. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. (PubMed id 9874765)1, 2, 3 Hsieh J.J.-D.... Hayward S.D. (1999)
    3. NKAP is a transcriptional repressor of notch signalin g and is required for T cell development. (PubMed id 19409814)1, 2 Pajerowski A.G....Shapiro V.S. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. (PubMed id 15652350)1, 3 Maita H....Iguchi-Ariga S.M. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A role for SKIP in EBNA2 activation of CBF1-repressed promoters. (PubMed id 10644367)1, 2 Zhou S....Hayward S.D. (2000)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Characterization of hNek6 interactome reveals an impo rtant role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)2 Vaz Meirelles G....Kobarg J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9541 HGNC: 24217 AceView: CIR Ensembl:ENSG00000138433 euGenes: HUgn9541
    ECgene: CIR1 Kegg: 9541 H-InvDB: CIR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CIR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CIR1 gene:
    Search GeneIP for patents involving CIR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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