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Aliases for CIR1 Gene

Aliases for CIR1 Gene

  • Corepressor Interacting With RBPJ, 1 2 3
  • Recepin 2 3 4
  • CBF1 Interacting Corepressor 2 3
  • CBF1-Interacting Corepressor 3 4
  • CIR 3 4
  • Corepressor Interacting With RBPJ 1 3

External Ids for CIR1 Gene

Previous GeneCards Identifiers for CIR1 Gene

  • GC02M174922
  • GC02M175212
  • GC02M167093

Summaries for CIR1 Gene

GeneCards Summary for CIR1 Gene

CIR1 (Corepressor Interacting With RBPJ, 1) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Notch signaling pathway (KEGG). GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for CIR1 Gene

  • May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Gene Wiki entry for CIR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIR1 Gene

Genomics for CIR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CIR1 Gene

Start:
174,348,022 bp from pter
End:
174,395,715 bp from pter
Size:
47,694 bases
Orientation:
Minus strand

Genomic View for CIR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIR1 Gene

No data available for Regulatory Elements for CIR1 Gene

Proteins for CIR1 Gene

  • Protein details for CIR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X95-CIR1_HUMAN
    Recommended name:
    Corepressor interacting with RBPJ 1
    Protein Accession:
    Q86X95
    Secondary Accessions:
    • A6NFI6
    • A8K8M4
    • O95367
    • Q12804
    • Q4G1B9
    • Q6PJI4
    • Q8IWI2

    Protein attributes for CIR1 Gene

    Size:
    450 amino acids
    Molecular mass:
    52313 Da
    Quaternary structure:
    • Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex.
    SequenceCaution:
    • Sequence=AAA17853.1; Type=Frameshift; Positions=135, 151, 177, 203, 261, 299, 391, 410; Evidence={ECO:0000305}; Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for CIR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIR1 Gene

Proteomics data for CIR1 Gene at MOPED

Post-translational modifications for CIR1 Gene

Other Protein References for CIR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CIR1 Gene

Domains for CIR1 Gene

Protein Domains for CIR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CIR1 Gene

Function for CIR1 Gene

Molecular function for CIR1 Gene

UniProtKB/Swiss-Prot Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Gene Ontology (GO) - Molecular Function for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9874765
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS 18663143
GO:0003714 transcription corepressor activity TAS 9874765
GO:0005515 protein binding IPI 15652350
genes like me logo Genes that share ontologies with CIR1: view

Phenotypes for CIR1 Gene

GenomeRNAi human phenotypes for CIR1:
genes like me logo Genes that share phenotypes with CIR1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CIR1 Gene

Localization for CIR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIR1 Gene

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIR1 Gene COMPARTMENTS Subcellular localization image for CIR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 9874765
GO:0005634 nucleus IDA 9874765
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with CIR1: view

Pathways for CIR1 Gene

genes like me logo Genes that share pathways with CIR1: view

Pathways by source for CIR1 Gene

1 BioSystems pathway for CIR1 Gene
1 KEGG pathway for CIR1 Gene
1 R&D Systems pathway for CIR1 Gene

Gene Ontology (GO) - Biological Process for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 18663143
GO:0006366 transcription from RNA polymerase II promoter TAS 18663143
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 9874765
genes like me logo Genes that share ontologies with CIR1: view

Transcripts for CIR1 Gene

Unigene Clusters for CIR1 Gene

Corepressor interacting with RBPJ, 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CIR1 Gene

GeneLoc Exon Structure for
CIR1
ECgene alternative splicing isoforms for
CIR1

Expression for CIR1 Gene

mRNA expression in normal human tissues for CIR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CIR1 Gene

SOURCE GeneReport for Unigene cluster for CIR1 Gene Hs.632531

mRNA Expression by UniProt/SwissProt for CIR1 Gene

Q86X95-CIR1_HUMAN
Tissue specificity: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with CIR1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CIR1 Gene

Orthologs for CIR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CIR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIR1 35
  • 99.7 (n)
  • 99.56 (a)
CIR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CIR1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIR1 35
  • 87.75 (n)
  • 85.08 (a)
mouse
(Mus musculus)
Mammalia Cir1 35
  • 91 (n)
  • 98.23 (a)
Cir1 16
Cir1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIR1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CIR1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cir1 35
  • 75.62 (n)
  • 75.23 (a)
chicken
(Gallus gallus)
Aves CIR1 35
  • 75.53 (n)
  • 72.07 (a)
CIR1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CIR1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22070 35
zebrafish
(Danio rerio)
Actinopterygii CIR1 36
  • 84 (a)
OneToOne
si:ch73-167c12.2 35
  • 76.07 (n)
  • 85.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6843 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cir-1 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 38
Species with no ortholog for CIR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CIR1 Gene

ENSEMBL:
Gene Tree for CIR1 (if available)
TreeFam:
Gene Tree for CIR1 (if available)

Paralogs for CIR1 Gene

Selected SIMAP similar genes for CIR1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CIR1 Gene

genes like me logo Genes that share paralogs with CIR1: view

No data available for Paralogs for CIR1 Gene

Variants for CIR1 Gene

Sequence variations from dbSNP and Humsavar for CIR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1063618 -- 174,348,876(-) TAGCA(C/G)TCACC missense, reference
rs1597418 -- 174,363,086(+) atgct(A/T)actct intron-variant
rs2122398 -- 174,385,561(+) ttgat(G/T)ccaat intron-variant
rs2167133 -- 174,369,140(+) aacta(A/C)cttca intron-variant
rs2167134 -- 174,385,376(+) ACAGT(A/C)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIR1 Gene

Variant ID Type Subtype PubMed ID
nsv875421 CNV Loss 21882294
dgv4366n71 CNV Loss 21882294

Relevant External Links for CIR1 Gene

HapMap Linkage Disequilibrium report
CIR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIR1 Gene

Disorders for CIR1 Gene

No disorders were found for CIR1 Gene.

No data available for UniProtKB/Swiss-Prot for CIR1 Gene

Publications for CIR1 Gene

  1. Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. (PMID: 11222720) Zhang J. … Hayward S.D. (J. Virol. 2001) 2 3 4
  2. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. (PMID: 9874765) Hsieh J.J.-D. … Hayward S.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  3. A role for SKIP in EBNA2 activation of CBF1-repressed promoters. (PMID: 10644367) Zhou S. … Hayward S.D. (J. Virol. 2000) 3 4
  4. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. (PMID: 19409814) Pajerowski A.G. … Shapiro V.S. (Immunity 2009) 3 4
  5. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3 4

Products for CIR1 Gene

Sources for CIR1 Gene

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