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Aliases for CIPC Gene

Aliases for CIPC Gene

  • CLOCK-Interacting Pacemaker 2 3 5
  • KIAA1737 2 3 4
  • CLOCK-Interacting Circadian Protein 3 4
  • CLOCK-Interacting Protein, Circadian 3
  • CLOCK-Interacting Protein 2
  • Circadian 2

External Ids for CIPC Gene

Previous HGNC Symbols for CIPC Gene

  • KIAA1737

Previous GeneCards Identifiers for CIPC Gene

  • GC14P077567

Summaries for CIPC Gene

GeneCards Summary for CIPC Gene

CIPC (CLOCK-Interacting Pacemaker) is a Protein Coding gene. An important paralog of this gene is ENSG00000259164.

UniProtKB/Swiss-Prot for CIPC Gene

  • Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIPC Gene

Genomics for CIPC Gene

Regulatory Elements for CIPC Gene

Promoters for CIPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CIPC on UCSC Golden Path with GeneCards custom track

Genomic Location for CIPC Gene

77,098,097 bp from pter
77,117,287 bp from pter
19,191 bases
Plus strand

Genomic View for CIPC Gene

Genes around CIPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIPC Gene

Proteins for CIPC Gene

  • Protein details for CIPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CLOCK-interacting pacemaker
    Protein Accession:
    Secondary Accessions:
    • B2RCI1
    • Q8N389
    • Q8NDZ1

    Protein attributes for CIPC Gene

    399 amino acids
    Molecular mass:
    42692 Da
    Quaternary structure:
    • Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
    • Sequence=BAB21828.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CIPC Gene

Proteomics data for CIPC Gene at MOPED

Post-translational modifications for CIPC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIPC Gene

No data available for DME Specific Peptides for CIPC Gene

Domains & Families for CIPC Gene

Protein Domains for CIPC Gene


Suggested Antigen Peptide Sequences for CIPC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIPC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CIPC Gene

Function for CIPC Gene

Molecular function for CIPC Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK (By similarity).

Phenotypes for CIPC Gene

genes like me logo Genes that share phenotypes with CIPC: view

Animal Model Products

miRNA for CIPC Gene

miRTarBase miRNAs that target CIPC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CIPC Gene

Localization for CIPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIPC Gene

Nucleus. Note=Co-localizes with CLOCK in the nucleus. {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CIPC Gene

Pathways & Interactions for CIPC Gene

SuperPathways for CIPC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042754 negative regulation of circadian rhythm IEA,ISS --
GO:0045892 negative regulation of transcription, DNA-templated IEA,ISS --
genes like me logo Genes that share ontologies with CIPC: view

No data available for Pathways by source and SIGNOR curated interactions for CIPC Gene

Drugs & Compounds for CIPC Gene

No Compound Related Data Available

Transcripts for CIPC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CIPC Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -

Relevant External Links for CIPC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CIPC Gene

mRNA expression in normal human tissues for CIPC Gene

mRNA differential expression in normal tissues according to GTEx for CIPC Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).
genes like me logo Genes that share expression patterns with CIPC: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CIPC Gene

Orthologs for CIPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIPC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIAA1737 35
  • 84.92 (n)
  • 86.68 (a)
KIAA1737 36
  • 87 (a)
(Canis familiaris)
Mammalia KIAA1737 35
  • 88.64 (n)
  • 93.73 (a)
-- 36
  • 94 (a)
(Mus musculus)
Mammalia Cipc 35
  • 85.22 (n)
  • 86.4 (a)
Cipc 16
2310044G17Rik 36
  • 83 (a)
(Pan troglodytes)
Mammalia KIAA1737 35
  • 99.75 (n)
  • 99.25 (a)
KIAA1737 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1309492 35
  • 85.81 (n)
  • 87.15 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
(Gallus gallus)
Aves KIAA1737 35
  • 59.32 (n)
  • 53.72 (a)
-- 36
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1737 35
  • 55.83 (n)
  • 47.92 (a)
(Danio rerio)
Actinopterygii LOC100535864 35
  • 53.37 (n)
  • 41.41 (a)
si:ch73-387e10.3 36
  • 33 (a)
si:dkey-204k5.2 36
  • 27 (a)
Species with no ortholog for CIPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIPC Gene

Gene Tree for CIPC (if available)
Gene Tree for CIPC (if available)

Paralogs for CIPC Gene

Paralogs for CIPC Gene

(1) SIMAP similar genes for CIPC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CIPC: view

Variants for CIPC Gene

Sequence variations from dbSNP and Humsavar for CIPC Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs11552006 - 77,105,799(+) GTCAG(C/T)TTGGG reference, missense
rs759593 - 77,113,725(+) AGCCA(A/G)CCAAG reference, missense
rs176163 -- 77,100,360(+) cctca(A/G)cctct intron-variant
rs767410 -- 77,117,372(-) GAGTA(C/T)CTATG downstream-variant-500B
rs1045823 -- 77,116,236(+) TCAGA(A/G)CAAAT utr-variant-3-prime

Variation tolerance for CIPC Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIPC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CIPC Gene

Disorders for CIPC Gene

Relevant External Links for CIPC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CIPC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIPC Gene

Publications for CIPC Gene

  1. Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. (PMID: 19414601) Yoshitane H. … Fukada Y. (Mol. Cell. Biol. 2009) 2 3 67
  2. CIPC is a mammalian circadian clock protein without invertebrate homologues. (PMID: 17310242) Zhao W.N. … Weitz C.J. (Nat. Cell Biol. 2007) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. (PMID: 23555304) Wallach T. … Kramer A. (PLoS Genet. 2013) 3

Products for CIPC Gene

Sources for CIPC Gene

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