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Aliases for CIPC Gene

Aliases for CIPC Gene

  • CLOCK-Interacting Pacemaker 2 3
  • KIAA1737 2 3 4
  • CLOCK-Interacting Circadian Protein 3 4
  • CLOCK-Interacting Protein, Circadian 3
  • CLOCK-Interacting Protein 2
  • Circadian 2

External Ids for CIPC Gene

Previous HGNC Symbols for CIPC Gene

  • KIAA1737

Previous GeneCards Identifiers for CIPC Gene

  • GC14P077567

Summaries for CIPC Gene

GeneCards Summary for CIPC Gene

CIPC (CLOCK-Interacting Pacemaker) is a Protein Coding gene. An important paralog of this gene is ENSG00000259164.

UniProtKB/Swiss-Prot for CIPC Gene

  • Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIPC Gene

Genomics for CIPC Gene

Genomic Location for CIPC Gene

Start:
77,098,097 bp from pter
End:
77,117,287 bp from pter
Size:
19,191 bases
Orientation:
Plus strand

Genomic View for CIPC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIPC Gene

No data available for Regulatory Elements for CIPC Gene

Proteins for CIPC Gene

  • Protein details for CIPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C6-CIPC_HUMAN
    Recommended name:
    CLOCK-interacting pacemaker
    Protein Accession:
    Q9C0C6
    Secondary Accessions:
    • B2RCI1
    • Q8N389
    • Q8NDZ1

    Protein attributes for CIPC Gene

    Size:
    399 amino acids
    Molecular mass:
    42692 Da
    Quaternary structure:
    • Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
    SequenceCaution:
    • Sequence=BAB21828.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CIPC Gene

Proteomics data for CIPC Gene at MOPED

Post-translational modifications for CIPC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIPC Gene

No data available for DME Specific Peptides for CIPC Gene

Domains for CIPC Gene

Protein Domains for CIPC Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIPC: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CIPC Gene

Function for CIPC Gene

Molecular function for CIPC Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK (By similarity).

Gene Ontology (GO) - Molecular Function for CIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CIPC: view

miRNA for CIPC Gene

miRTarBase miRNAs that target CIPC

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CIPC Gene

Localization for CIPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIPC Gene

Nucleus. Note=Co-localizes with CLOCK in the nucleus. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with CIPC: view

No data available for Subcellular locations from COMPARTMENTS for CIPC Gene

Pathways for CIPC Gene

SuperPathways for CIPC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0042754 negative regulation of circadian rhythm ISS --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with CIPC: view

No data available for Pathways by source for CIPC Gene

Transcripts for CIPC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CIPC Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -

Relevant External Links for CIPC Gene

GeneLoc Exon Structure for
CIPC
ECgene alternative splicing isoforms for
CIPC

Expression for CIPC Gene

mRNA expression in normal human tissues for CIPC Gene

mRNA differential expression in normal tissues according to GTEx for CIPC Gene

This gene is overexpressed in Muscle - Skeletal (5.4).
genes like me logo Genes that share expressions with CIPC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for CIPC Gene

Orthologs for CIPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1737 35
  • 99.75 (n)
  • 99.25 (a)
KIAA1737 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1737 35
  • 84.92 (n)
  • 86.68 (a)
KIAA1737 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 94 (a)
OneToMany
KIAA1737 35
  • 88.64 (n)
  • 93.73 (a)
mouse
(Mus musculus)
Mammalia 2310044G17Rik 16
2310044G17Rik 36
  • 83 (a)
OneToMany
Cipc 35
  • 85.22 (n)
  • 86.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1309492 35
  • 85.81 (n)
  • 87.15 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 53 (a)
OneToMany
KIAA1737 35
  • 59.32 (n)
  • 53.72 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1737 35
  • 55.83 (n)
  • 47.92 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535864 35
  • 53.37 (n)
  • 41.41 (a)
si:ch73-387e10.3 36
  • 33 (a)
ManyToMany
si:dkey-204k5.2 36
  • 27 (a)
ManyToMany
Species with no ortholog for CIPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIPC Gene

ENSEMBL:
Gene Tree for CIPC (if available)
TreeFam:
Gene Tree for CIPC (if available)

Paralogs for CIPC Gene

Paralogs for CIPC Gene

Selected SIMAP similar genes for CIPC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CIPC: view

Variants for CIPC Gene

Sequence variations from dbSNP and Humsavar for CIPC Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs158103 -- 77,101,322(+) CGAAA(C/G)AGTAA intron-variant
rs176163 -- 77,100,360(+) cctca(A/G)cctct intron-variant
rs204979 -- 77,098,635(+) CCCTG(C/G)TCTAG intron-variant
rs432679 -- 77,115,452(+) TGTTA(A/G)ATATT utr-variant-3-prime
rs759592 -- 77,106,204(+) TAGTT(G/T)CCATG intron-variant

Relevant External Links for CIPC Gene

HapMap Linkage Disequilibrium report
CIPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CIPC Gene

Disorders for CIPC Gene

No disorders were found for CIPC Gene.

No data available for UniProtKB/Swiss-Prot for CIPC Gene

Publications for CIPC Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. (PMID: 19414601) Yoshitane H. … Fukada Y. (Mol. Cell. Biol. 2009) 2 3
  5. CIPC is a mammalian circadian clock protein without invertebrate homologues. (PMID: 17310242) Zhao W.N. … Weitz C.J. (Nat. Cell Biol. 2007) 2 3

Products for CIPC Gene

Sources for CIPC Gene

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