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Aliases for CIPC Gene

Aliases for CIPC Gene

  • CLOCK Interacting Pacemaker 2 3 5
  • KIAA1737 2 3 4
  • CLOCK-Interacting Protein, Circadian 2 3
  • CLOCK-Interacting Circadian Protein 3 4
  • CLOCK-Interacting Pacemaker 3

External Ids for CIPC Gene

Previous HGNC Symbols for CIPC Gene

  • KIAA1737

Previous GeneCards Identifiers for CIPC Gene

  • GC14P077567

Summaries for CIPC Gene

GeneCards Summary for CIPC Gene

CIPC (CLOCK Interacting Pacemaker) is a Protein Coding gene. An important paralog of this gene is ENSG00000259164.

UniProtKB/Swiss-Prot for CIPC Gene

  • Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIPC Gene

Genomics for CIPC Gene

Regulatory Elements for CIPC Gene

Enhancers for CIPC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F077119 1 FANTOM5 Ensembl ENCODE 18.3 +24.6 24601 6.3 PKNOX1 TBL1XR1 KLF17 SIN3A BMI1 RAD21 ZNF121 ZNF143 ZNF207 ETV6 CIPC ENSG00000201384 LOC102724190 LOC283575 IRF2BPL TMED8 NGB TMEM63C ENSG00000269883
GH14F077133 0.8 ENCODE 16.5 +35.8 35846 0.2 ELF3 MLX ARID4B SIN3A ZNF48 ZSCAN9 RARA SLC30A9 ZNF143 CREM CIPC ENSG00000201384 NGB MIR1260A SAMD15 TMED8 ENSG00000269883 TMEM63C
GH14F077003 1.3 Ensembl ENCODE 15.6 -90.9 -90850 7.2 PKNOX1 KLF17 FEZF1 ZNF2 RAD21 YY1 ZNF121 HSF1 SCRT2 FOS ALKBH1 CIPC SNW1 IRF2BPL RPL22P2 RPL21P10 ZMYND19P1 LINC01629 GC14P077023 GC14M076985
GH14F077010 1.2 Ensembl ENCODE 15 -86.6 -86647 1.2 GATA3 RAD21 CIPC LINC01629 GC14P077023 GC14M076985
GH14F077021 1.5 VISTA FANTOM5 ENCODE 13.7 -63.7 -63718 25.6 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC POMT2 CIPC ENSG00000259081 LOC283575 IRF2BPL TMEM63C VASH1 TMED8 LRRC74A LOC105370579
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CIPC on UCSC Golden Path with GeneCards custom track

Promoters for CIPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098947 403 3001 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for CIPC Gene

Chromosome:
14
Start:
77,098,097 bp from pter
End:
77,117,287 bp from pter
Size:
19,191 bases
Orientation:
Plus strand

Genomic View for CIPC Gene

Genes around CIPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIPC Gene

Proteins for CIPC Gene

  • Protein details for CIPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C6-CIPC_HUMAN
    Recommended name:
    CLOCK-interacting pacemaker
    Protein Accession:
    Q9C0C6
    Secondary Accessions:
    • B2RCI1
    • Q8N389
    • Q8NDZ1

    Protein attributes for CIPC Gene

    Size:
    399 amino acids
    Molecular mass:
    42692 Da
    Quaternary structure:
    • Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer. Interacts with CAD AND HSPA5 (PubMed:26657846).
    SequenceCaution:
    • Sequence=BAB21828.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CIPC Gene

Post-translational modifications for CIPC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIPC Gene

No data available for DME Specific Peptides for CIPC Gene

Domains & Families for CIPC Gene

Protein Domains for CIPC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIPC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIPC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CIPC Gene

Function for CIPC Gene

Molecular function for CIPC Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.

Gene Ontology (GO) - Molecular Function for CIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CIPC: view

Phenotypes for CIPC Gene

genes like me logo Genes that share phenotypes with CIPC: view

Animal Model Products

miRNA for CIPC Gene

miRTarBase miRNAs that target CIPC

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CIPC Gene

Localization for CIPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIPC Gene

Nucleus. Cytoplasm, cytosol. Note=Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol. {ECO:0000250 UniProtKB:Q8R0W1, ECO:0000269 PubMed:26657846}.

Gene Ontology (GO) - Cellular Components for CIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CIPC: view

No data available for Subcellular locations from COMPARTMENTS for CIPC Gene

Pathways & Interactions for CIPC Gene

SuperPathways for CIPC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042754 negative regulation of circadian rhythm IEA,ISS --
GO:0045892 negative regulation of transcription, DNA-templated IEA,ISS --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with CIPC: view

No data available for Pathways by source and SIGNOR curated interactions for CIPC Gene

Transcripts for CIPC Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIPC Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -

Relevant External Links for CIPC Gene

GeneLoc Exon Structure for
CIPC
ECgene alternative splicing isoforms for
CIPC

Expression for CIPC Gene

mRNA expression in normal human tissues for CIPC Gene

mRNA differential expression in normal tissues according to GTEx for CIPC Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of CIPC Gene:

CIPC
genes like me logo Genes that share expression patterns with CIPC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CIPC Gene

Orthologs for CIPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1737 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
OneToMany
KIAA1737 34
  • 88.64 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309492 34
  • 85.81 (n)
mouse
(Mus musculus)
Mammalia Cipc 34 16
  • 85.22 (n)
2310044G17Rik 35
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KIAA1737 34 35
  • 84.92 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA1737 34
  • 59.32 (n)
-- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1737 34
  • 55.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535864 34
  • 53.37 (n)
si:ch73-387e10.3 35
  • 33 (a)
ManyToMany
si:dkey-204k5.2 35
  • 27 (a)
ManyToMany
Species where no ortholog for CIPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIPC Gene

ENSEMBL:
Gene Tree for CIPC (if available)
TreeFam:
Gene Tree for CIPC (if available)

Paralogs for CIPC Gene

Paralogs for CIPC Gene

(1) SIMAP similar genes for CIPC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CIPC: view

Variants for CIPC Gene

Sequence variations from dbSNP and Humsavar for CIPC Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10150832 -- 77,109,239(+) CCAAC(A/G)TTTAT intron-variant
rs10150952 -- 77,109,304(+) CCTTC(C/T)AGTCA intron-variant
rs1045823 -- 77,116,236(+) TCAGA(A/G)CAAAT utr-variant-3-prime
rs10483881 -- 77,116,140(+) CTGAT(G/T)TAGAA utr-variant-3-prime
rs10585198 -- 77,110,694(+) TTAGA(-/ATAGA)GAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CIPC Gene

Variant ID Type Subtype PubMed ID
nsv832834 CNV gain+loss 17160897

Variation tolerance for CIPC Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIPC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIPC Gene

Disorders for CIPC Gene

Relevant External Links for CIPC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIPC

No disorders were found for CIPC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIPC Gene

Publications for CIPC Gene

  1. Versatile function of the circadian protein CIPC as a regulator of Erk activation. (PMID: 26657846) Matsunaga R. … Konishi H. (Biochem. Biophys. Res. Commun. 2016) 3 4 64
  2. Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. (PMID: 19414601) Yoshitane H. … Fukada Y. (Mol. Cell. Biol. 2009) 2 3 64
  3. CIPC is a mammalian circadian clock protein without invertebrate homologues. (PMID: 17310242) Zhao W.N. … Weitz C.J. (Nat. Cell Biol. 2007) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CIPC Gene

Sources for CIPC Gene

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